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Aliases for TRAPPC3 Gene

Aliases for TRAPPC3 Gene

  • Trafficking Protein Particle Complex 3 2 3 5
  • BET3 3 4
  • BET3 Homolog 4

External Ids for TRAPPC3 Gene

Previous GeneCards Identifiers for TRAPPC3 Gene

  • GC01M036028
  • GC01M036029
  • GC01M036271
  • GC01M036374
  • GC01M036602
  • GC01M034719

Summaries for TRAPPC3 Gene

Entrez Gene Summary for TRAPPC3 Gene

  • This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for TRAPPC3 Gene

TRAPPC3 (Trafficking Protein Particle Complex 3) is a Protein Coding gene. Diseases associated with TRAPPC3 include tietz albinism-deafness syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. An important paralog of this gene is TRAPPC3L.

UniProtKB/Swiss-Prot for TRAPPC3 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Wiki entry for TRAPPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC3 Gene

Genomics for TRAPPC3 Gene

Regulatory Elements for TRAPPC3 Gene

Genomic Location for TRAPPC3 Gene

Chromosome:
1
Start:
36,136,569 bp from pter
End:
36,156,053 bp from pter
Size:
19,485 bases
Orientation:
Minus strand

Genomic View for TRAPPC3 Gene

Genes around TRAPPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC3 Gene

Proteins for TRAPPC3 Gene

  • Protein details for TRAPPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43617-TPPC3_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 3
    Protein Accession:
    O43617
    Secondary Accessions:
    • A6NDN0
    • B2RDN2
    • D3DPS2

    Protein attributes for TRAPPC3 Gene

    Size:
    180 amino acids
    Molecular mass:
    20274 Da
    Quaternary structure:
    • Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.

    Three dimensional structures from OCA and Proteopedia for TRAPPC3 Gene

    Alternative splice isoforms for TRAPPC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC3 Gene

Proteomics data for TRAPPC3 Gene at MOPED

Post-translational modifications for TRAPPC3 Gene

  • Ubiquitination at Lys 13, Lys 46, and Lys 156
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TRAPPC3

No data available for DME Specific Peptides for TRAPPC3 Gene

Domains & Families for TRAPPC3 Gene

Gene Families for TRAPPC3 Gene

Suggested Antigen Peptide Sequences for TRAPPC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43617

UniProtKB/Swiss-Prot:

TPPC3_HUMAN :
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC3: view

Function for TRAPPC3 Gene

Molecular function for TRAPPC3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC3: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC3 Gene

miRTarBase miRNAs that target TRAPPC3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC3 Gene

Localization for TRAPPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC3 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC3 Gene COMPARTMENTS Subcellular localization image for TRAPPC3 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endoplasmic reticulum 4
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0030008 TRAPP complex IEA --
genes like me logo Genes that share ontologies with TRAPPC3: view

Pathways & Interactions for TRAPPC3 Gene

genes like me logo Genes that share pathways with TRAPPC3: view

Gene Ontology (GO) - Biological Process for TRAPPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TRAPPC3: view

No data available for SIGNOR curated interactions for TRAPPC3 Gene

Drugs & Compounds for TRAPPC3 Gene

(3) Drugs for TRAPPC3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma Target 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 20
S-PALMITOYL-L-CYSTEINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAPPC3: view

Transcripts for TRAPPC3 Gene

Unigene Clusters for TRAPPC3 Gene

Trafficking protein particle complex 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: -
SP10: - - - - - - - - - - - - - -

Relevant External Links for TRAPPC3 Gene

GeneLoc Exon Structure for
TRAPPC3
ECgene alternative splicing isoforms for
TRAPPC3

Expression for TRAPPC3 Gene

mRNA expression in normal human tissues for TRAPPC3 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC3 Gene

This gene is overexpressed in Bone (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC3 Gene



SOURCE GeneReport for Unigene cluster for TRAPPC3 Gene Hs.523131

genes like me logo Genes that share expression patterns with TRAPPC3: view

Protein tissue co-expression partners for TRAPPC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC3 Gene

Orthologs for TRAPPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC3 36
  • 100 (a)
OneToOne
TRAPPC3 35
  • 100 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRAPPC3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC3 36
  • 99 (a)
OneToOne
TRAPPC3 35
  • 94.68 (n)
  • 97.87 (a)
mouse
(Mus musculus)
Mammalia Trappc3 16
Trappc3 36
  • 98 (a)
OneToOne
Trappc3 35
  • 89.07 (n)
  • 97.78 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc3 35
  • 90.74 (n)
  • 97.78 (a)
chicken
(Gallus gallus)
Aves TRAPPC3 35
  • 82.41 (n)
  • 94.44 (a)
TRAPPC3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC3 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia trappc3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1115 35
trappc3 35
  • 77.78 (n)
  • 91.67 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc3 36
  • 87 (a)
OneToOne
Dr.21964 35
trappc3 35
  • 76.48 (n)
  • 87.22 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013291 35
  • 59.55 (n)
  • 61.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bet3 35
  • 60.49 (n)
  • 61.8 (a)
Bet3 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK1098.5 35
  • 51.9 (n)
  • 51.5 (a)
trpp-3 36
  • 49 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR300W 35
  • 55.62 (n)
  • 54.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET3 36
  • 50 (a)
OneToMany
BET3 38
BET3 35
  • 56.59 (n)
  • 56.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16126g 35
  • 55.56 (n)
  • 56.55 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1118 35
soybean
(Glycine max)
eudicotyledons Gma.933 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G54750 35
  • 57.95 (n)
  • 53.49 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2943 35
corn
(Zea mays)
Liliopsida Zm.3039 35
rice
(Oryza sativa)
Liliopsida Os.3933 35
Os03g0402000 35
  • 59.8 (n)
  • 55.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05796 35
  • 59.75 (n)
  • 54.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bet3 35
  • 58.08 (n)
  • 55.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8333 36
  • 69 (a)
OneToMany
Species with no ortholog for TRAPPC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC3 Gene

ENSEMBL:
Gene Tree for TRAPPC3 (if available)
TreeFam:
Gene Tree for TRAPPC3 (if available)

Paralogs for TRAPPC3 Gene

Paralogs for TRAPPC3 Gene

(1) SIMAP similar genes for TRAPPC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAPPC3: view

Variants for TRAPPC3 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1033890 -- 36,142,813(-) ggctc(A/G)agtga intron-variant
rs1033891 -- 36,142,801(-) ccttc(C/T)gcctc intron-variant
rs1408557 -- 36,136,252(-) GGGTG(C/T)TATTT downstream-variant-500B
rs1408558 -- 36,136,116(-) TTAGG(G/T)TTCAA downstream-variant-500B
rs2231303 -- 36,150,180(-) AGCTG(A/G)GATTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC3 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834691 CNV Loss 17160897
nsv871804 CNV Loss 21882294
nsv870558 CNV Loss 21882294
nsv10106 CNV Gain 18304495

Variation tolerance for TRAPPC3 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC3 Gene

HapMap Linkage Disequilibrium report
TRAPPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC3 Gene

Disorders for TRAPPC3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAPPC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
tietz albinism-deafness syndrome
  • tietze's syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRAPPC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC3
genes like me logo Genes that share disorders with TRAPPC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC3 Gene

Publications for TRAPPC3 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 3 4 67
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TRAPPC3 Gene

Sources for TRAPPC3 Gene

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