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TRAPPC3 Gene

protein-coding   GIFtS: 56
GCID: GC01M036602

Trafficking Protein Particle Complex 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trafficking Protein Particle Complex 31 2
BET32 3 5
Trafficking Protein Particle Complex Subunit 32
BET3 Homolog3

External Ids:    HGNC: 199421   Entrez Gene: 270952   Ensembl: ENSG000000541167   OMIM: 6109555   UniProtKB: O436173   

Export aliases for TRAPPC3 gene to outside databases

Previous GC identifers: GC01M036028 GC01M036029 GC01M036271 GC01M036374 GC01M034719


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAPPC3 Gene:
This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the
cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic
reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Aug 2012)

GeneCards Summary for TRAPPC3 Gene:
TRAPPC3 (trafficking protein particle complex 3) is a protein-coding gene. Diseases associated with TRAPPC3 include septic arthritis, and conjunctivitis. An important paralog of this gene is TRAPPC3L.

UniProtKB/Swiss-Prot: TPPC3_HUMAN, O43617
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAPPC3 gene promoter:
         HOXA9B   HOXA9   RREB-1   MyoD   Ik-3   MEF-2A   c-Myb   ARP-1   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAPPC3 promoter sequence
   Search Chromatin IP Primers for TRAPPC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAPPC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.2

TRAPPC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M036602:  view genomic region     (about GC identifiers)

Start:
36,602,173 bp from pter      End:
36,615,098 bp from pter
Size:
12,926 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TPPC3_HUMAN, O43617 (See protein sequence)
Recommended Name: Trafficking protein particle complex subunit 3  
Size: 180 amino acids; 20274 Da
Subunit: Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at
least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L
4 PDB 3D structures from and Proteopedia for TRAPPC3:
1SZ7 (3D)        2C0J (3D)        2CFH (3D)        3KXC (3D)    
Secondary accessions: A6NDN0 B2RDN2 D3DPS2
Alternative splicing: 2 isoforms:  O43617-1   O43617-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TRAPPC3: NX_O43617

Explore proteomics data for TRAPPC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys13, Lys46, Lys156
  • Modification sites at PhosphoSitePlus

  • See TRAPPC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257823.1  NP_001257824.1  NP_001257825.1  NP_001257826.1  NP_055223.1  

    ENSEMBL proteins: 
     ENSP00000362261   ENSP00000362257   ENSP00000362256   ENSP00000362253  

    TRAPPC3 Human Recombinant Protein Products:

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    TRAPPC3 Assay Products:

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    Cloud-Clone Corp. CLIAs for TRAPPC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRAPPC: Trafficking protein particle complex

    3 InterPro protein domains:
     IPR007194 TRAPP_component
     IPR016721 TRAPP_I_complex_Bet3
     IPR024096 NO_sig/Golgi_transp_ligand-bd

    Graphical View of Domain Structure for InterPro Entry O43617

    ProtoNet protein and cluster: O43617

    1 Blocks protein domain: IPB007194 Transport protein particle (TRAPP) component

    UniProtKB/Swiss-Prot: TPPC3_HUMAN, O43617
    Similarity: Belongs to the TRAPP small subunits family. BET3 subfamily


    TRAPPC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPPC3_HUMAN, O43617
    Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    TRAPPC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAPPC3:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAPPC3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAPPC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAPPC3

    miRNA
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    miRTarBase miRNAs that target TRAPPC3:
    hsa-mir-1 (MIRT002767), hsa-mir-26b-5p (MIRT030205)

    Block miRNA regulation of human, mouse, rat TRAPPC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAPPC3 (see all 10):
    hsa-miR-3607-3p hsa-miR-206 hsa-miR-3688-3p hsa-miR-622 hsa-miR-1 hsa-miR-410 hsa-miR-583 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC3

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    GenScript: all cDNA clones in your preferred vector: TRAPPC3 (NM_014408)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPPC3_HUMAN, O43617: Golgi apparatus, cis-Golgi network (By similarity). Endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    cytosol3
    endoplasmic reticulum2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol IEA--

    TRAPPC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRAPPC3
    Interactions:

        Search GeneGlobe Interaction Network for TRAPPC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAPPC3 (O436171, 2, 3 ENSP000003622614) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAPPC6AO758651, 2, 3, ENSP000000062754EBI-743566,EBI-743573 MINT-6785415 MINT-6785068 MINT-6784856 MINT-66356 MINT-6785038 I2D: score=5 STRING: ENSP00000006275
    TRAPPC6BQ86SZ21, 2, 3, ENSP000003302894EBI-743566,EBI-6160531 MINT-6785068 MINT-6785053 MINT-6784845 I2D: score=3 STRING: ENSP00000330289
    TRAPPC9Q96Q052, 3, ENSP000003739794MINT-6784879 I2D: score=1 STRING: ENSP00000373979
    TRAPPC2LQ9UL332, 3, ENSP000003010214MINT-8201511 I2D: score=5 STRING: ENSP00000301021
    TRAPPC4Q9Y2963, ENSP000003518964I2D: score=6 STRING: ENSP00000351896
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006888ER to Golgi vesicle-mediated transport IEA--

    TRAPPC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAPPC3 (TPPC3)

    3 DrugBank Compounds for TRAPPC3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MYRISTIC ACID-- --target--10592235
    S-PALMITOYL-L-CYSTEINE-- --target--10592235
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAPPC3 gene (5 alternative transcripts): 
    NM_001270894.1  NM_001270895.1  NM_001270896.1  NM_001270897.1  NM_014408.4  

    Unigene Cluster for TRAPPC3:

    Trafficking protein particle complex 3
    Hs.523131  [show with all ESTs]
    Unigene Representative Sequence: NM_001270896
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373166(uc001bzx.3) ENST00000462715 ENST00000373163 ENST00000373162
    ENST00000469757 ENST00000373159 ENST00000497251
    miRNA
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    Block miRNA regulation of human, mouse, rat TRAPPC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAPPC3 (see all 10):
    hsa-miR-3607-3p hsa-miR-206 hsa-miR-3688-3p hsa-miR-622 hsa-miR-1 hsa-miR-410 hsa-miR-583 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRAPPC3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAPPC3 (NM_014408)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC3
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    OriGene qPCR primer pairs and template standards for TRAPPC3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAPPC3
      QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC3
      QuantiFast Probe-based Assays in human, mouse, rat TRAPPC3

    Additional mRNA sequence: 

    AF041432.1 AJ224335.1 AK315610.1 AY007139.1 BC007662.2 NR_073097.1 NR_073098.1 

    17 DOTS entries:

    DT.416253  DT.100824015  DT.91754781  DT.100824021  DT.102821845  DT.100824010  DT.99970159  DT.87078369 
    DT.100824013  DT.121363564  DT.95199688  DT.100061020  DT.100824018  DT.305148  DT.100824017  DT.91754775 
    DT.91754777 

    Selected AceView cDNA sequences (see all 248):

    CR610083 CA421776 AI351374 BE304853 BM509907 AW236317 CK822672 BU159576 
    CA306429 BM458299 BM475004 AI335352 AK094755 BQ057016 AA970395 BE898138 
    BQ716573 BI258608 AI804514 CN484503 NM_014408 CN484388 BE875884 BG677844 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                -     -     -     -                 -                 -                       -                                       
    SP2:                                -     -     -     -                                   -                       -                                       
    SP3:                                -     -     -     -                 -                                                                                 
    SP4:                                            -     -                 -                 -                       -                                       
    SP5:                                -     -     -     -           -     -     -           -                       -                                       


    ECgene alternative splicing isoforms for TRAPPC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAPPC3 expression in normal human tissues (normalized intensities)      TRAPPC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGGAAACAC
    TRAPPC3 Expression
    About this image


    TRAPPC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Thyroid (Endocrine System)
     
     Adrenal Gland (Endocrine System)
    TRAPPC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAPPC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523131
        Custom PCR Arrays for TRAPPC3
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    QuantiFast Probe-based Assays in human, mouse, rat TRAPPC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRAPPC3 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trappc31 , 5 trafficking protein particle complex 31, 5 89.07(n)1
    97.78(a)1
      4 (60.23 cM)5
    270961  NM_013718.21  NP_038746.11 
     1262623255 
    chicken
    (Gallus gallus)
    Aves TRAPPC31 trafficking protein particle complex 3 82.41(n)
    94.44(a)
      419625  NM_001008451.1  NP_001008451.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAPPC36
    trafficking protein particle complex 3
    93(a)
    1 ↔ 1
    GL344158.1(41929-48904)
    African clawed frog
    (Xenopus laevis)
    Amphibia trappc3-prov2 trafficking protein particle complex 3 78.28(n)    BC053802.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.219642 Transcribed sequence with moderate similarity to protein more 76.71(n)    57053667 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bet31 Bet3 60.49(n)
    61.8(a)
      39090  NM_140055.4  NP_648312.3 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK1098.51 ZK1098.5 51.9(n)
    51.5(a)
      176344  NM_066699.4  NP_499100.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BET3(YKR068C)4
    BET31
    Hydrophilic protein that acts in conjunction with SNARE more4
    BET31
    56.59(n)1
    56.98(a)1
      11(570909-570328)4
    8539421, 4  NP_012994.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G547501 AT5G54750 57.95(n)
    53.49(a)
      835565  NM_001203610.1  NP_001190539.1 
    rice
    (Oryza sativa)
    Liliopsida Os.39332 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.62(n)    AK103200.1 


    ENSEMBL Gene Tree for TRAPPC3 (if available)
    TreeFam Gene Tree for TRAPPC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAPPC3 gene
    TRAPPC3L2  
    1 SIMAP similar gene for TRAPPC3 using alignment to 2 protein entries:     TPPC3_HUMAN (see all proteins):
    TRAPPC3L

    TRAPPC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAPPC3 (see all 381)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs14085581,2
    C,F,H--36601717(-) TTAGGG/TTTCAA 7 -- ds500119Minor allele frequency- T:0.08EA NA NS WA 2276
    rs1880698951,2
    --36601760(+) ACTTAC/TGGCCT 7 -- ds50010--------
    rs1141138291,2
    C,F--36601801(+) GCCAAT/CGCATG 7 -- ds50011Minor allele frequency- C:0.03WA 118
    rs14085571,2
    F,A,H--36601853(-) GGGTGC/TTATTT 7 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs1828549501,2
    --36602016(+) AGTTGC/TTTATA 7 -- ds50010--------
    rs37677051,2
    C,F,A,H--36602044(+) CAGACT/ACTCTC 7 -- ds500114Minor allele frequency- A:0.27EA NA WA CSA 1859
    rs46531611,2
    C,F--36602202(+) CTTTAT/CTGAAG 7 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.03NA 120
    rs1175661101,2
    --36602332(+) TTTCCA/C/TGGCAA 14 -- ut31 nc-transcript-variant1EA 120
    rs1475882971,2
    --36602406(+) TCCACA/CCCACA 7 -- ut31 nc-transcript-variant0--------
    rs1420962681,2
    --36602597(+) GGGGGA/CAGAGA 7 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TRAPPC3 (36602173 - 36615098 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRAPPC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870558CNV Loss21882294
    nsv871804CNV Loss21882294
    nsv834691CNV Loss17160897
    nsv10106CNV Gain18304495
    nsv871396CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAPPC3
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAPPC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610955    OMIM disorders: --

    4 diseases for TRAPPC3:    About MalaCards
    septic arthritis    conjunctivitis    arthritis    cerebritis


    TRAPPC3 for disorders           About GeneDecksing


    Export disorders for TRAPPC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAPPC3 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TRAPPC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2 Scrivens P.J.... Sacher M. (Mol. Biol. Cell 2011)
    2. Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p. (PubMed id 16262728)1, 2 Kim M.-S.... Sacher M. (Traffic 2005)
    3. Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization. (PubMed id 15692564)1, 2 Turnbull A.P.... Heinemann U. (EMBO J. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)1, 2 Gavin A.-C....Superti-Furga G. (Nature 2002)
    7. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. (PubMed id 9564032)1, 2 Sacher M.... Ferro-Novick S. (EMBO J. 1998)
    8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27095 HGNC: 19942 AceView: TRAPPC3 Ensembl:ENSG00000054116 euGenes: HUgn27095
    ECgene: TRAPPC3 H-InvDB: TRAPPC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRAPPC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRAPPC3 gene:
    Search GeneIP for patents involving TRAPPC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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