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Aliases for TRAPPC3 Gene

Aliases for TRAPPC3 Gene

  • Trafficking Protein Particle Complex 3 2 3
  • BET3 3 4 6
  • Trafficking Protein Particle Complex Subunit 3 3
  • BET3 Homolog 4

External Ids for TRAPPC3 Gene

Previous GeneCards Identifiers for TRAPPC3 Gene

  • GC01M036028
  • GC01M036029
  • GC01M036271
  • GC01M036374
  • GC01M036602
  • GC01M034719

Summaries for TRAPPC3 Gene

Entrez Gene Summary for TRAPPC3 Gene

  • This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for TRAPPC3 Gene

TRAPPC3 (Trafficking Protein Particle Complex 3) is a Protein Coding gene. An important paralog of this gene is TRAPPC3L.

UniProtKB/Swiss-Prot for TRAPPC3 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC3 Gene

Genomics for TRAPPC3 Gene

Regulatory Elements for TRAPPC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAPPC3 Gene

Start:
36,136,569 bp from pter
End:
36,156,053 bp from pter
Size:
19,485 bases
Orientation:
Minus strand

Genomic View for TRAPPC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC3 Gene

Proteins for TRAPPC3 Gene

  • Protein details for TRAPPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43617-TPPC3_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 3
    Protein Accession:
    O43617
    Secondary Accessions:
    • A6NDN0
    • B2RDN2
    • D3DPS2

    Protein attributes for TRAPPC3 Gene

    Size:
    180 amino acids
    Molecular mass:
    20274 Da
    Quaternary structure:
    • Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.

    Three dimensional structures from OCA and Proteopedia for TRAPPC3 Gene

    Alternative splice isoforms for TRAPPC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC3 Gene

Proteomics data for TRAPPC3 Gene at MOPED

Post-translational modifications for TRAPPC3 Gene

  • Ubiquitination at Lys13, Lys46, and Lys156
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC3 Gene

Domains for TRAPPC3 Gene

Gene Families for TRAPPC3 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Suggested Antigen Peptide Sequences for TRAPPC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43617

UniProtKB/Swiss-Prot:

TPPC3_HUMAN :
  • O43617
Family:
  • Belongs to the TRAPP small subunits family. BET3 subfamily.
genes like me logo Genes that share domains with TRAPPC3: view

Function for TRAPPC3 Gene

Molecular function for TRAPPC3 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO) - Molecular Function for TRAPPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRAPPC3: view

Phenotypes for TRAPPC3 Gene

GenomeRNAi human phenotypes for TRAPPC3:
genes like me logo Genes that share phenotypes with TRAPPC3: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC3 Gene

miRTarBase miRNAs that target TRAPPC3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC3 Gene

Localization for TRAPPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC3 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC3 Gene COMPARTMENTS Subcellular localization image for TRAPPC3 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
endoplasmic reticulum 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol --
GO:0030008 TRAPP complex --
genes like me logo Genes that share ontologies with TRAPPC3: view

Pathways for TRAPPC3 Gene

SuperPathways for TRAPPC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC3: view

No data available for Pathways by source for TRAPPC3 Gene

Compounds for TRAPPC3 Gene

(3) Drugbank Compounds for TRAPPC3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
MYRISTIC ACID
target
Palmitic Acid
  • 1-Hexyldecanoic Acid
57-10-3 target
S-PALMITOYL-L-CYSTEINE
target
genes like me logo Genes that share compounds with TRAPPC3: view

Transcripts for TRAPPC3 Gene

Unigene Clusters for TRAPPC3 Gene

Trafficking protein particle complex 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8: - -
SP9: -
SP10: - - - - - - - - - - - - - -

Relevant External Links for TRAPPC3 Gene

GeneLoc Exon Structure for
TRAPPC3
ECgene alternative splicing isoforms for
TRAPPC3

Expression for TRAPPC3 Gene

mRNA expression in normal human tissues for TRAPPC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC3 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC3 Gene Hs.523131

genes like me logo Genes that share expressions with TRAPPC3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC3 Gene

Orthologs for TRAPPC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC3 35
  • 100 (n)
  • 100 (a)
TRAPPC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC3 35
  • 94.68 (n)
  • 97.87 (a)
TRAPPC3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc3 35
  • 89.07 (n)
  • 97.78 (a)
Trappc3 16
Trappc3 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc3 35
  • 90.74 (n)
  • 97.78 (a)
chicken
(Gallus gallus)
Aves TRAPPC3 35
  • 82.41 (n)
  • 94.44 (a)
TRAPPC3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC3 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia trappc3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1115 35
trappc3 35
  • 77.78 (n)
  • 91.67 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.21964 35
trappc3 35
  • 76.48 (n)
  • 87.22 (a)
trappc3 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013291 35
  • 59.55 (n)
  • 61.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bet3 35
  • 60.49 (n)
  • 61.8 (a)
Bet3 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trpp-3 36
  • 49 (a)
OneToMany
ZK1098.5 35
  • 51.9 (n)
  • 51.5 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR300W 35
  • 55.62 (n)
  • 54.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET3 35
  • 56.59 (n)
  • 56.98 (a)
BET3 36
  • 50 (a)
OneToMany
BET3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16126g 35
  • 55.56 (n)
  • 56.55 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1118 35
soybean
(Glycine max)
eudicotyledons Gma.933 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G54750 35
  • 57.95 (n)
  • 53.49 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2943 35
corn
(Zea mays)
Liliopsida Zm.3039 35
rice
(Oryza sativa)
Liliopsida Os.3933 35
Os03g0402000 35
  • 59.8 (n)
  • 55.76 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05796 35
  • 59.75 (n)
  • 54.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bet3 35
  • 58.08 (n)
  • 55.69 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8333 36
  • 69 (a)
OneToMany
Species with no ortholog for TRAPPC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC3 Gene

ENSEMBL:
Gene Tree for TRAPPC3 (if available)
TreeFam:
Gene Tree for TRAPPC3 (if available)

Paralogs for TRAPPC3 Gene

Paralogs for TRAPPC3 Gene

Selected SIMAP similar genes for TRAPPC3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAPPC3: view

Variants for TRAPPC3 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1033890 -- 36,142,813(-) ggctc(A/G)agtga intron-variant
rs1033891 -- 36,142,801(-) ccttc(C/T)gcctc intron-variant
rs1408557 -- 36,136,252(-) GGGTG(C/T)TATTT downstream-variant-500B
rs1408558 -- 36,136,116(-) TTAGG(G/T)TTCAA downstream-variant-500B
rs2147448 -- 36,140,332(-) TGCTT(C/T)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC3 Gene

Variant ID Type Subtype PubMed ID
nsv871396 CNV Gain 21882294
nsv834691 CNV Loss 17160897
nsv871804 CNV Loss 21882294
nsv870558 CNV Loss 21882294
nsv10106 CNV Gain 18304495

Relevant External Links for TRAPPC3 Gene

HapMap Linkage Disequilibrium report
TRAPPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC3 Gene

Disorders for TRAPPC3 Gene

No disorders were found for TRAPPC3 Gene.

No data available for UniProtKB/Swiss-Prot for TRAPPC3 Gene

Publications for TRAPPC3 Gene

  1. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  2. TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. (PMID: 9564032) Sacher M. … Ferro-Novick S. (EMBO J. 1998) 3 4
  3. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAPPC3 Gene

Sources for TRAPPC3 Gene

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