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Aliases for TRAPPC2L Gene

Aliases for TRAPPC2L Gene

  • Trafficking Protein Particle Complex 2 Like 2 3 5
  • Trafficking Protein Particle Complex Subunit 2-Like Protein 3
  • Trafficking Protein Particle Complex 2-Like 2
  • Hematopoietic Stem/Progenitor Cells 176 3
  • HSPC176 3

External Ids for TRAPPC2L Gene

Previous GeneCards Identifiers for TRAPPC2L Gene

  • GC16P087452
  • GC16P088923
  • GC16P074620

Summaries for TRAPPC2L Gene

Entrez Gene Summary for TRAPPC2L Gene

  • This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRAPPC2L Gene

TRAPPC2L (Trafficking Protein Particle Complex 2 Like) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for TRAPPC2L Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC2L Gene

Genomics for TRAPPC2L Gene

Regulatory Elements for TRAPPC2L Gene

Enhancers for TRAPPC2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F088920 1.7 FANTOM5 Ensembl ENCODE 24.4 +68.4 68429 9.3 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF766 TRAPPC2L CBFA2T3 PABPN1L GALNS LOC100289580 SNORD68 LOC100129697 APRT CDK10 LOC105371409
GH16F089313 2 VISTA FANTOM5 Ensembl ENCODE 12.1 +464.8 464790 15.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP5 LOC100289580 ENSG00000259877 TRAPPC2L CTU2 FAM157C ENSG00000261172 AFG3L1P CDK10 DBNDD1 ZNF276
GH16F089112 1.7 FANTOM5 Ensembl ENCODE 12.1 +262.2 262219 11.3 HDGF PKNOX1 CREB3L1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 FOS ACSF3 ENSG00000259877 CTU2 TRAPPC2L GALNS RNF166 TUBB3 CYBA SNAI3 ENSG00000260279
GH16F089246 1.6 FANTOM5 Ensembl ENCODE 12.8 +391.5 391466 2.4 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 GLIS2 PAF1 SP5 MXD4 ENSG00000259877 TRAPPC2L ZNF778 ENSG00000260279 ACSF3 SLC22A31 ZNF276 LOC105371413 PIR44316
GH16F088452 1.5 FANTOM5 ENCODE 12.1 -401.3 -401284 6.0 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ENSG00000259877 RNF166 CTU2 TRAPPC2L ZFPM1 LOC100289580 ENSG00000268218 ENSG00000260121 ZCCHC14 ZC3H18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAPPC2L on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054068 1080 2201 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS SP3

Genomic Location for TRAPPC2L Gene

88,856,220 bp from pter
88,862,686 bp from pter
6,467 bases
Plus strand

Genomic View for TRAPPC2L Gene

Genes around TRAPPC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC2L Gene

Proteins for TRAPPC2L Gene

  • Protein details for TRAPPC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 2-like protein
    Protein Accession:
    Secondary Accessions:
    • B2R4M9
    • Q6ZTA7
    • Q9NZZ4

    Protein attributes for TRAPPC2L Gene

    140 amino acids
    Molecular mass:
    16146 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A. Interacts with TRAPPC6A.
    • Sequence=BAC86686.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC2L Gene


neXtProt entry for TRAPPC2L Gene

Post-translational modifications for TRAPPC2L Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC2L Gene

Domains & Families for TRAPPC2L Gene

Gene Families for TRAPPC2L Gene

Protein Domains for TRAPPC2L Gene

Suggested Antigen Peptide Sequences for TRAPPC2L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
genes like me logo Genes that share domains with TRAPPC2L: view

Function for TRAPPC2L Gene

Molecular function for TRAPPC2L Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Ontology (GO) - Molecular Function for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRAPPC2L: view
genes like me logo Genes that share phenotypes with TRAPPC2L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC2L Gene

Localization for TRAPPC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC2L Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC2L gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TRAPPC2L: view

Pathways & Interactions for TRAPPC2L Gene

genes like me logo Genes that share pathways with TRAPPC2L: view

Gene Ontology (GO) - Biological Process for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0048208 COPII vesicle coating TAS --
genes like me logo Genes that share ontologies with TRAPPC2L: view

No data available for SIGNOR curated interactions for TRAPPC2L Gene

Transcripts for TRAPPC2L Gene

Unigene Clusters for TRAPPC2L Gene

Trafficking protein particle complex 2-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - -
SP10: -
SP11: -

Relevant External Links for TRAPPC2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRAPPC2L Gene

Protein differential expression in normal tissues from HIPED for TRAPPC2L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.0) and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAPPC2L Gene

Protein tissue co-expression partners for TRAPPC2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC2L Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC2L Gene:


mRNA Expression by UniProt/SwissProt for TRAPPC2L Gene:

Tissue specificity: Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.
genes like me logo Genes that share expression patterns with TRAPPC2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAPPC2L Gene

Orthologs for TRAPPC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC2L 34 35
  • 99.52 (n)
(Monodelphis domestica)
Mammalia TRAPPC2L 35
  • 94 (a)
(Bos Taurus)
Mammalia TRAPPC2L 34 35
  • 89.21 (n)
(Rattus norvegicus)
Mammalia Trappc2l 34
  • 89.21 (n)
(Canis familiaris)
Mammalia TRAPPC2L 34 35
  • 88.97 (n)
(Mus musculus)
Mammalia Trappc2l 34 16 35
  • 88.97 (n)
(Ornithorhynchus anatinus)
Mammalia TRAPPC2L 35
  • 71 (a)
(Gallus gallus)
Aves TRAPPC2L 34 35
  • 84.41 (n)
(Anolis carolinensis)
Reptilia TRAPPC2L 35
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc2l 34
  • 78.18 (n)
(Danio rerio)
Actinopterygii trappc2l 34
  • 78.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9067 34 35
  • 63.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013488 34
  • 61.98 (n)
(Caenorhabditis elegans)
Secernentea T10F2.5 35
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20930 34
  • 55.39 (n)
(Oryza sativa)
Liliopsida Os09g0541500 34
  • 54.39 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6514 35
  • 59 (a)
Species where no ortholog for TRAPPC2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC2L Gene

Gene Tree for TRAPPC2L (if available)
Gene Tree for TRAPPC2L (if available)

Paralogs for TRAPPC2L Gene Pseudogenes for TRAPPC2L Gene

genes like me logo Genes that share paralogs with TRAPPC2L: view

No data available for Paralogs for TRAPPC2L Gene

Variants for TRAPPC2L Gene

Sequence variations from dbSNP and Humsavar for TRAPPC2L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs794726887 Likely pathogenic 88,856,767(-) TGCTC(-/CTGCTC)ATGGA intron-variant, upstream-variant-2KB, cds-indel
rs794729202 Likely pathogenic 88,856,831(-) GCTGG(A/T)GCTCA intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1046540 -- 88,860,985(+) TCGCA(A/G/T)AGGAG nc-transcript-variant, utr-variant-3-prime
rs1046606 -- 88,859,623(+) CGGCA(A/G)TCCCT intron-variant, nc-transcript-variant, reference, missense
rs11076728 -- 88,859,159(+) GCCTC(G/T)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC2L Gene

Variant ID Type Subtype PubMed ID
nsv952071 CNV deletion 24416366
nsv819907 CNV gain 19587683
nsv573674 CNV gain 21841781
nsv521217 CNV loss 19592680
nsv482951 CNV loss 15286789
nsv471115 CNV loss 18288195
nsv1063441 CNV loss 25217958
nsv1063024 CNV gain 25217958
nsv1061256 CNV gain 25217958
esv3639561 CNV gain 21293372
esv3639555 CNV gain 21293372
dgv37n68 CNV loss 17160897
dgv3065n100 CNV gain 25217958

Variation tolerance for TRAPPC2L Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC2L Gene

Disorders for TRAPPC2L Gene

Relevant External Links for TRAPPC2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAPPC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC2L Gene

Publications for TRAPPC2L Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. (PMID: 19416478) Scrivens P.J. … Sacher M. (Traffic 2009) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for TRAPPC2L Gene

Sources for TRAPPC2L Gene

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