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Aliases for TRAPPC2L Gene

Aliases for TRAPPC2L Gene

  • Trafficking Protein Particle Complex 2-Like 2 3 5
  • Hematopoietic Stem/Progenitor Cells 176 3
  • HSPC176 3

External Ids for TRAPPC2L Gene

Previous GeneCards Identifiers for TRAPPC2L Gene

  • GC16P087452
  • GC16P088923
  • GC16P074620

Summaries for TRAPPC2L Gene

Entrez Gene Summary for TRAPPC2L Gene

  • This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for TRAPPC2L Gene

TRAPPC2L (Trafficking Protein Particle Complex 2-Like) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport.

UniProtKB/Swiss-Prot for TRAPPC2L Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC2L Gene

Genomics for TRAPPC2L Gene

Regulatory Elements for TRAPPC2L Gene

Enhancers for TRAPPC2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC2L on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC2L on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC2L Gene

Chromosome:
16
Start:
88,856,220 bp from pter
End:
88,862,686 bp from pter
Size:
6,467 bases
Orientation:
Plus strand

Genomic View for TRAPPC2L Gene

Genes around TRAPPC2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC2L Gene

Proteins for TRAPPC2L Gene

  • Protein details for TRAPPC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL33-TPC2L_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 2-like protein
    Protein Accession:
    Q9UL33
    Secondary Accessions:
    • B2R4M9
    • Q6ZTA7
    • Q9NZZ4

    Protein attributes for TRAPPC2L Gene

    Size:
    140 amino acids
    Molecular mass:
    16146 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A. Interacts with TRAPPC6A.
    SequenceCaution:
    • Sequence=BAC86686.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC2L Gene

Proteomics data for TRAPPC2L Gene at MOPED

Post-translational modifications for TRAPPC2L Gene

  • Ubiquitination at Lys 48
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC2L Gene

Domains & Families for TRAPPC2L Gene

Gene Families for TRAPPC2L Gene

Protein Domains for TRAPPC2L Gene

Suggested Antigen Peptide Sequences for TRAPPC2L Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL33

UniProtKB/Swiss-Prot:

TPC2L_HUMAN :
  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
Family:
  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
genes like me logo Genes that share domains with TRAPPC2L: view

Function for TRAPPC2L Gene

Molecular function for TRAPPC2L Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC2L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC2L Gene

Localization for TRAPPC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC2L Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC2L Gene COMPARTMENTS Subcellular localization image for TRAPPC2L gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TRAPPC2L: view

Pathways & Interactions for TRAPPC2L Gene

genes like me logo Genes that share pathways with TRAPPC2L: view

Gene Ontology (GO) - Biological Process for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with TRAPPC2L: view

No data available for SIGNOR curated interactions for TRAPPC2L Gene

Drugs & Compounds for TRAPPC2L Gene

No Compound Related Data Available

Transcripts for TRAPPC2L Gene

Unigene Clusters for TRAPPC2L Gene

Trafficking protein particle complex 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - -
SP10: -
SP11: -

Relevant External Links for TRAPPC2L Gene

GeneLoc Exon Structure for
TRAPPC2L
ECgene alternative splicing isoforms for
TRAPPC2L

Expression for TRAPPC2L Gene

mRNA expression in normal human tissues for TRAPPC2L Gene

Protein differential expression in normal tissues from HIPED for TRAPPC2L Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.0) and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAPPC2L Gene



SOURCE GeneReport for Unigene cluster for TRAPPC2L Gene Hs.461722

mRNA Expression by UniProt/SwissProt for TRAPPC2L Gene

Q9UL33-TPC2L_HUMAN
Tissue specificity: Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.
genes like me logo Genes that share expression patterns with TRAPPC2L: view

Protein tissue co-expression partners for TRAPPC2L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAPPC2L Gene

Orthologs for TRAPPC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAPPC2L 35
  • 89.21 (n)
  • 97.84 (a)
TRAPPC2L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC2L 35
  • 88.97 (n)
  • 97.12 (a)
TRAPPC2L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc2l 35
  • 88.97 (n)
  • 98.56 (a)
Trappc2l 16
Trappc2l 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC2L 35
  • 99.52 (n)
  • 100 (a)
TRAPPC2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc2l 35
  • 89.21 (n)
  • 98.56 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC2L 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC2L 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAPPC2L 35
  • 84.41 (n)
  • 94.96 (a)
TRAPPC2L 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC2L 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc2l 35
  • 78.18 (n)
  • 92.09 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc2l 35
  • 78.1 (n)
  • 86.86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013488 35
  • 61.98 (n)
  • 52.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9067 35
  • 63.68 (n)
  • 55.22 (a)
CG9067 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T10F2.5 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20930 35
  • 55.39 (n)
  • 48.12 (a)
rice
(Oryza sativa)
Liliopsida Os09g0541500 35
  • 54.39 (n)
  • 47.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6514 36
  • 59 (a)
OneToOne
Species with no ortholog for TRAPPC2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC2L Gene

ENSEMBL:
Gene Tree for TRAPPC2L (if available)
TreeFam:
Gene Tree for TRAPPC2L (if available)

Paralogs for TRAPPC2L Gene

Pseudogenes.org Pseudogenes for TRAPPC2L Gene

genes like me logo Genes that share paralogs with TRAPPC2L: view

No data available for Paralogs for TRAPPC2L Gene

Variants for TRAPPC2L Gene

Sequence variations from dbSNP and Humsavar for TRAPPC2L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs14489 -- 88,861,054(+) ACGCC(C/T)GGGGC utr-variant-3-prime
rs4530120 -- 88,861,680(-) CTGAC(A/G/T)CCACT utr-variant-3-prime
rs9927684 -- 88,859,047(+) AGGAA(C/G)TGGGA intron-variant
rs1046540 -- 88,860,985(+) TCGCA(A/G/T)AGGAG utr-variant-3-prime
rs1046606 -- 88,859,623(+) CGGCA(A/G)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC2L Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907268 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
dgv2989n71 CNV Gain 21882294
nsv907320 CNV Loss 21882294
dgv2990n71 CNV Loss 21882294
dgv37n68 CNV Loss 17160897
dgv2992n71 CNV Loss 21882294
dgv2996n71 CNV Loss 21882294
nsv471115 CNV Loss 18288195
nsv819907 CNV Gain 19587683
nsv521217 CNV Loss 19592680
nsv907352 CNV Loss 21882294
dgv2997n71 CNV Loss 21882294
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294

Variation tolerance for TRAPPC2L Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRAPPC2L Gene

Disorders for TRAPPC2L Gene

Relevant External Links for TRAPPC2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC2L

No disorders were found for TRAPPC2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC2L Gene

Publications for TRAPPC2L Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Slow overmethylation of housekeeping genes in the body mucosa is associated with the risk for gastric cancer. (PMID: 24654229) Oh J.H. … Hong S.J. (Cancer Prev Res (Phila) 2014) 3

Products for TRAPPC2L Gene

Sources for TRAPPC2L Gene

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