Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAPPC2L Gene

Aliases for TRAPPC2L Gene

  • Trafficking Protein Particle Complex 2-Like 2 3
  • Trafficking Protein Particle Complex Subunit 2-Like Protein 3
  • Hematopoietic Stem/Progenitor Cells 176 3
  • HSPC176 3

External Ids for TRAPPC2L Gene

Summaries for TRAPPC2L Gene

GeneCards Summary for TRAPPC2L Gene

TRAPPC2L (Trafficking Protein Particle Complex 2-Like) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRAPPC2L Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC2L Gene

Genomics for TRAPPC2L Gene

Genomic Location for TRAPPC2L Gene

Start:
88,856,220 bp from pter
End:
88,862,686 bp from pter
Size:
6,467 bases
Orientation:
Plus strand

Genomic View for TRAPPC2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC2L Gene

Regulatory Elements for TRAPPC2L Gene

Proteins for TRAPPC2L Gene

  • Protein details for TRAPPC2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL33-TPC2L_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 2-like protein
    Protein Accession:
    Q9UL33
    Secondary Accessions:
    • B2R4M9
    • Q6ZTA7
    • Q9NZZ4

    Protein attributes for TRAPPC2L Gene

    Size:
    140 amino acids
    Molecular mass:
    16146 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with the heterodimer TRAPPC3-TRAPPC6A. Interacts with TRAPPC6A.
    SequenceCaution:
    • Sequence=BAC86686.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC2L Gene

Proteomics data for TRAPPC2L Gene at MOPED

Post-translational modifications for TRAPPC2L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48

No data available for DME Specific Peptides for TRAPPC2L Gene

Domains for TRAPPC2L Gene

Protein Domains for TRAPPC2L Gene

Suggested Antigen Peptide Sequences for TRAPPC2L Gene

Graphical View of Domain Structure for InterPro Entry

Q9UL33

UniProtKB/Swiss-Prot:

TPC2L_HUMAN
Family:
  • Belongs to the TRAPP small subunits family. Sedlin subfamily.:
    • Q9UL33
genes like me logo Genes that share domains with TRAPPC2L: view

No data available for Gene Families for TRAPPC2L Gene

Function for TRAPPC2L Gene

Molecular function for TRAPPC2L Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Ontology (GO) - Molecular Function for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRAPPC2L: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAPPC2L Gene

Localization for TRAPPC2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC2L Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC2L Gene COMPARTMENTS Subcellular localization image for TRAPPC2L gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network --
genes like me logo Genes that share ontologies with TRAPPC2L: view

Pathways for TRAPPC2L Gene

SuperPathways for TRAPPC2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006888 ER to Golgi vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC2L: view

No data available for Pathways by source for TRAPPC2L Gene

Transcripts for TRAPPC2L Gene

Unigene Clusters for TRAPPC2L Gene

Trafficking protein particle complex 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - - - -
SP10: -
SP11: -

Relevant External Links for TRAPPC2L Gene

GeneLoc Exon Structure for
TRAPPC2L
ECgene alternative splicing isoforms for
TRAPPC2L

Expression for TRAPPC2L Gene

mRNA expression in normal human tissues for TRAPPC2L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRAPPC2L Gene

SOURCE GeneReport for Unigene cluster for TRAPPC2L Gene Hs.461722

mRNA Expression by UniProt/SwissProt for TRAPPC2L Gene

Q9UL33-TPC2L_HUMAN
Tissue specificity: Expressed in testis, liver, bladder, lung, spleen and brain, several cell lines and primary chondrocytes cell line.
genes like me logo Genes that share expressions with TRAPPC2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAPPC2L Gene

Orthologs for TRAPPC2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC2L 35
  • 99.52 (n)
  • 100 (a)
TRAPPC2L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC2L 35
  • 89.21 (n)
  • 97.84 (a)
TRAPPC2L 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC2L 35
  • 88.97 (n)
  • 97.12 (a)
TRAPPC2L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc2l 35
  • 88.97 (n)
  • 98.56 (a)
Trappc2l 16
Trappc2l 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC2L 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC2L 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc2l 35
  • 89.21 (n)
  • 98.56 (a)
chicken
(Gallus gallus)
Aves TRAPPC2L 35
  • 84.41 (n)
  • 94.96 (a)
TRAPPC2L 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC2L 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc2l 35
  • 78.18 (n)
  • 92.09 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc2l 35
  • 78.1 (n)
  • 86.86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013488 35
  • 61.98 (n)
  • 52.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9067 35
  • 63.68 (n)
  • 55.22 (a)
CG9067 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T10F2.5 36
  • 31 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20930 35
  • 55.39 (n)
  • 48.12 (a)
rice
(Oryza sativa)
Liliopsida Os09g0541500 35
  • 54.39 (n)
  • 47.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6514 36
  • 59 (a)
OneToOne
Species with no ortholog for TRAPPC2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC2L Gene

ENSEMBL:
Gene Tree for TRAPPC2L (if available)
TreeFam:
Gene Tree for TRAPPC2L (if available)

Paralogs for TRAPPC2L Gene

Pseudogenes.org Pseudogenes for TRAPPC2L Gene

genes like me logo Genes that share paralogs with TRAPPC2L: view

No data available for Paralogs for TRAPPC2L Gene

Variants for TRAPPC2L Gene

Sequence variations from dbSNP and Humsavar for TRAPPC2L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs14489 -- 88,861,054(+) ACGCC(C/T)GGGGC utr-variant-3-prime
rs1046540 -- 88,860,985(+) TCGCA(A/G)AGGAG utr-variant-3-prime
rs1046606 -- 88,859,623(+) CGGCA(A/G)TCCCT intron-variant
rs3784873 -- 88,859,581(-) AGAAA(C/T)GTGGC intron-variant
rs3784874 -- 88,859,552(-) ATGCC(C/T)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC2L Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907268 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
dgv2989n71 CNV Gain 21882294
nsv907320 CNV Loss 21882294
dgv2990n71 CNV Loss 21882294
dgv37n68 CNV Loss 17160897
dgv2992n71 CNV Loss 21882294
dgv2996n71 CNV Loss 21882294
nsv471115 CNV Loss 18288195
nsv819907 CNV Gain 19587683
nsv521217 CNV Loss 19592680
nsv907352 CNV Loss 21882294
dgv2997n71 CNV Loss 21882294
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294

Relevant External Links for TRAPPC2L Gene

HapMap Linkage Disequilibrium report
TRAPPC2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC2L Gene

Disorders for TRAPPC2L Gene

No disorders were found for TRAPPC2L Gene.

No data available for UniProtKB/Swiss-Prot for TRAPPC2L Gene

Publications for TRAPPC2L Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. (PMID: 19416478) Scrivens P.J. … Sacher M. (Traffic 2009) 3 4
  4. Organization and assembly of the TRAPPII complex. (PMID: 21453443) Choi C. … Conibear E. (Traffic 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRAPPC2L Gene

Sources for TRAPPC2L Gene

Back to Top

Content