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Aliases for TRAPPC2 Gene

Aliases for TRAPPC2 Gene

  • Trafficking Protein Particle Complex 2 2 3 5
  • Sedlin 3 4
  • SEDL 3 4
  • Spondyloepiphyseal Dysplasia, Late 2
  • TRAPPC2P1 3
  • HYP38334 3
  • ZNF547L 3
  • MIP2A 3
  • TRS20 3
  • SEDT 3

External Ids for TRAPPC2 Gene

Previous HGNC Symbols for TRAPPC2 Gene

  • SEDL

Previous GeneCards Identifiers for TRAPPC2 Gene

  • GC00U913615
  • GC0XM013492

Summaries for TRAPPC2 Gene

Entrez Gene Summary for TRAPPC2 Gene

  • The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for TRAPPC2 Gene

TRAPPC2 (Trafficking Protein Particle Complex 2) is a Protein Coding gene. Diseases associated with TRAPPC2 include Spondyloepiphyseal Dysplasia Tarda and Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include transcription factor binding and ion channel binding. An important paralog of this gene is TRAPPC2B.

UniProtKB/Swiss-Prot for TRAPPC2 Gene

  • Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Wiki entry for TRAPPC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC2 Gene

Genomics for TRAPPC2 Gene

Regulatory Elements for TRAPPC2 Gene

Enhancers for TRAPPC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC2 on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC2 Gene

13,712,242 bp from pter
13,734,635 bp from pter
22,394 bases
Minus strand

Genomic View for TRAPPC2 Gene

Genes around TRAPPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC2 Gene

Proteins for TRAPPC2 Gene

  • Protein details for TRAPPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 2
    Protein Accession:
    Secondary Accessions:
    • A6NEG0
    • O14582
    • Q9HD16

    Protein attributes for TRAPPC2 Gene

    140 amino acids
    Molecular mass:
    16445 Da
    Quaternary structure:
    • Can homodimerize. Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with ENO1, PITX1 and SF1.
    • A paralogous gene encoding an identical protein appears to have arisen by retrotransposition of a cDNA from this locus and to have acquired a promoter and non-coding 5 UTR from the ZNF547 gene.

    Alternative splice isoforms for TRAPPC2 Gene

neXtProt entry for TRAPPC2 Gene

Proteomics data for TRAPPC2 Gene at MOPED

Post-translational modifications for TRAPPC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC2 Gene

No data available for DME Specific Peptides for TRAPPC2 Gene

Domains & Families for TRAPPC2 Gene

Gene Families for TRAPPC2 Gene

Protein Domains for TRAPPC2 Gene


Suggested Antigen Peptide Sequences for TRAPPC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
  • Belongs to the TRAPP small subunits family. Sedlin subfamily.
genes like me logo Genes that share domains with TRAPPC2: view

Function for TRAPPC2 Gene

Molecular function for TRAPPC2 Gene

UniProtKB/Swiss-Prot Function:
Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC2: view

Human Phenotype Ontology for TRAPPC2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TRAPPC2 Gene

miRTarBase miRNAs that target TRAPPC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC2 Gene

Localization for TRAPPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC2 Gene

Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Localized in perinuclear granular structures.

Subcellular locations from

Jensen Localization Image for TRAPPC2 Gene COMPARTMENTS Subcellular localization image for TRAPPC2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRAPPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12681486
genes like me logo Genes that share ontologies with TRAPPC2: view

Pathways & Interactions for TRAPPC2 Gene

genes like me logo Genes that share pathways with TRAPPC2: view

Gene Ontology (GO) - Biological Process for TRAPPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with TRAPPC2: view

No data available for SIGNOR curated interactions for TRAPPC2 Gene

Drugs & Compounds for TRAPPC2 Gene

No Compound Related Data Available

Transcripts for TRAPPC2 Gene

Unigene Clusters for TRAPPC2 Gene

Trafficking protein particle complex 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC2 Gene

No ASD Table

Relevant External Links for TRAPPC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC2 Gene

mRNA expression in normal human tissues for TRAPPC2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAPPC2 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC2 Gene Hs.592238

mRNA Expression by UniProt/SwissProt for TRAPPC2 Gene

Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes.
genes like me logo Genes that share expression patterns with TRAPPC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TRAPPC2 Gene

Orthologs for TRAPPC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRAPPC2 35
  • 91.9 (n)
  • 98.57 (a)
  • 99 (a)
(Canis familiaris)
Mammalia TRAPPC2 35
  • 93.65 (n)
  • 98.64 (a)
  • 79 (a)
(Mus musculus)
Mammalia Trappc2 35
  • 90.71 (n)
  • 97.86 (a)
Trappc2 16
0610009B22Rik 36
  • 95 (a)
Trappc2 36
  • 98 (a)
(Pan troglodytes)
Mammalia TRAPPC2 35
  • 100 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Trappc2 35
  • 93.1 (n)
  • 97.86 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
-- 36
  • 97 (a)
(Gallus gallus)
Aves TRAPPC2 35
  • 83.33 (n)
  • 95.71 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
-- 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc2 35
  • 79.76 (n)
  • 92.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18543 35
(Danio rerio)
Actinopterygii Dr.16486 35
trappc2 35
  • 78.57 (n)
  • 92.14 (a)
egfl6 36
  • 92 (a)
trappc2 36
  • 96 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002528 35
  • 65.7 (n)
  • 64.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)72Dh 35
  • 62.08 (n)
  • 57.97 (a)
l(3)72Dh 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea sedl-1 35
  • 56.13 (n)
  • 55.88 (a)
sedl-1 36
  • 53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR246W 35
  • 54.23 (n)
  • 44.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15763g 35
  • 52.93 (n)
  • 44.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS20 35
  • 50.13 (n)
  • 42.86 (a)
TRS20 36
  • 32 (a)
TRS20 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80500 35
  • 59.26 (n)
  • 51.11 (a)
(Oryza sativa)
Liliopsida Os02g0613600 35
  • 59.01 (n)
  • 51.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11174 35
  • 50.25 (n)
  • 46.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trs20 35
  • 53.88 (n)
  • 48.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
Species with no ortholog for TRAPPC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC2 Gene

Gene Tree for TRAPPC2 (if available)
Gene Tree for TRAPPC2 (if available)

Paralogs for TRAPPC2 Gene

Paralogs for TRAPPC2 Gene

(1) SIMAP similar genes for TRAPPC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAPPC2: view

Variants for TRAPPC2 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_012358 Spondyloepiphyseal dysplasia tarda (SEDT)
VAR_012359 Spondyloepiphyseal dysplasia tarda (SEDT)
VAR_012360 Spondyloepiphyseal dysplasia tarda (SEDT)
VAR_012361 Spondyloepiphyseal dysplasia tarda (SEDT)
rs749591674 -- 13,712,255(+) CAAAC(A/C)TCTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC2 Gene

Variant ID Type Subtype PubMed ID
nsv528634 CNV Gain 19592680

Variation tolerance for TRAPPC2 Gene

Gene Damage Index Score: 0.07; 1.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC2 Gene

Disorders for TRAPPC2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TRAPPC2 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
spondyloepiphyseal dysplasia tarda
  • mucopolysaccharidosis iv
spondyloepiphyseal dysplasia with congenital joint dislocations
  • mucopolysaccharidosis iv
skeletal dysplasias
  • osteochondrodysplasias
  • benign symmetrical lipomatosis
leber hereditary optic neuropathy
  • leber optic atrophy
- elite association - COSMIC cancer census association via MalaCards


  • Spondyloepiphyseal dysplasia tarda (SEDT) [MIM:313400]: X-linked recessive disorder of endochondral bone formation. {ECO:0000269 PubMed:10431248, ECO:0000269 PubMed:11349230, ECO:0000269 PubMed:11424925}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRAPPC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRAPPC2: view

No data available for Genatlas for TRAPPC2 Gene

Publications for TRAPPC2 Gene

  1. Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not. (PMID: 14597397) Gecz J. … de Barros Lopes M. (Gene 2003) 2 3 4 67
  2. Noncanonical and canonical splice sites: a novel mutation at the rare noncanonical splice-donor cut site (IVS4+1A>G) of SEDL causes variable splicing isoforms in X-linked spondyloepiphyseal dysplasia tarda. (PMID: 19002213) Xiong F. … He L. (Eur. J. Hum. Genet. 2009) 3 23
  3. A novel RNA-splicing mutation in TRAPPC2 gene causing x-linked spondyloepiphyseal dysplasia tarda in a large Chinese family. (PMID: 19417549) Guo H. … Bai Y. (J. Genet. 2009) 3 23
  4. A novel insertion mutation in the SEDL gene results in X-linked spondyloepiphyseal dysplasia tarda in a large Chinese pedigree. (PMID: 19766614) Xia X.Y. … Huang T.T. (Clin. Chim. Acta 2009) 3 23
  5. [A novel mutation in the SEDL gene leading to X-linked spondyloepiphyseal dysplasia tarda in a large Chinese pedigree]. (PMID: 18393234) Lin Y. … Yang Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008) 3 23

Products for TRAPPC2 Gene

Sources for TRAPPC2 Gene