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Aliases for TRAPPC12 Gene

Aliases for TRAPPC12 Gene

  • Trafficking Protein Particle Complex 12 2 3 5
  • Tetratricopeptide Repeat Protein 15 3 4
  • Tetratricopeptide Repeat Domain 15 2 3
  • TPR Repeat Protein 15 3 4
  • TTC-15 3 4
  • TTC15 3 4
  • CGI-87 3

External Ids for TRAPPC12 Gene

Previous HGNC Symbols for TRAPPC12 Gene

  • TTC15

Summaries for TRAPPC12 Gene

GeneCards Summary for TRAPPC12 Gene

TRAPPC12 (Trafficking Protein Particle Complex 12) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and endopeptidase activity.

UniProtKB/Swiss-Prot for TRAPPC12 Gene

  • May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC12 Gene

Genomics for TRAPPC12 Gene

Regulatory Elements for TRAPPC12 Gene

Promoters for TRAPPC12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC12 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC12 Gene

Chromosome:
2
Start:
3,379,672 bp from pter
End:
3,485,094 bp from pter
Size:
105,423 bases
Orientation:
Plus strand

Genomic View for TRAPPC12 Gene

Genes around TRAPPC12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC12 Gene

Proteins for TRAPPC12 Gene

  • Protein details for TRAPPC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVT3-TPC12_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 12
    Protein Accession:
    Q8WVT3
    Secondary Accessions:
    • B3KV01
    • D6W4Y2
    • Q8WVW1
    • Q9Y395

    Protein attributes for TRAPPC12 Gene

    Size:
    735 amino acids
    Molecular mass:
    79375 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=AAD34082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRAPPC12 Gene

Proteomics data for TRAPPC12 Gene at MOPED

Post-translational modifications for TRAPPC12 Gene

  • Ubiquitination at Lys 354, Lys 364, Lys 385, Lys 510, and Lys 601
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAPPC12 Gene

Domains & Families for TRAPPC12 Gene

Protein Domains for TRAPPC12 Gene

Suggested Antigen Peptide Sequences for TRAPPC12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVT3

UniProtKB/Swiss-Prot:

TPC12_HUMAN :
  • Contains 4 TPR repeats.
Similarity:
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TRAPPC12: view

Function for TRAPPC12 Gene

Molecular function for TRAPPC12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Ontology (GO) - Molecular Function for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
genes like me logo Genes that share ontologies with TRAPPC12: view

Phenotypes for TRAPPC12 Gene

genes like me logo Genes that share phenotypes with TRAPPC12: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC12 Gene

miRTarBase miRNAs that target TRAPPC12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC12 Gene

Localization for TRAPPC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC12 Gene

Endoplasmic reticulum-Golgi intermediate compartment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC12 Gene COMPARTMENTS Subcellular localization image for TRAPPC12 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TRAPPC12 Gene

Pathways & Interactions for TRAPPC12 Gene

SuperPathways for TRAPPC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAPPC12 Gene

Drugs & Compounds for TRAPPC12 Gene

No Compound Related Data Available

Transcripts for TRAPPC12 Gene

Unigene Clusters for TRAPPC12 Gene

Trafficking protein particle complex 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRAPPC12 Gene

GeneLoc Exon Structure for
TRAPPC12
ECgene alternative splicing isoforms for
TRAPPC12

Expression for TRAPPC12 Gene

mRNA expression in normal human tissues for TRAPPC12 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7), Liver (9.1), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC12 Gene



SOURCE GeneReport for Unigene cluster for TRAPPC12 Gene Hs.252713

genes like me logo Genes that share expression patterns with TRAPPC12: view

Protein tissue co-expression partners for TRAPPC12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC12 Gene

Orthologs for TRAPPC12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC15 36
  • 99 (a)
OneToOne
TTC15 35
  • 99.14 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia TTC15 35
  • 78.54 (n)
  • 77.17 (a)
TTC15 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC12 36
  • 71 (a)
OneToOne
TRAPPC12 35
  • 78.37 (n)
  • 78.55 (a)
mouse
(Mus musculus)
Mammalia Trappc12 16
Trappc12 36
  • 73 (a)
OneToOne
Trappc12 35
  • 76.64 (n)
  • 79.32 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAPPC12 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC12 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc12 35
  • 77.88 (n)
  • 79.56 (a)
chicken
(Gallus gallus)
Aves TRAPPC12 35
  • 69.65 (n)
  • 75.53 (a)
TRAPPC12 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC12 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25574 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4089 35
trappc12 35
  • 67 (n)
  • 68.97 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc12 36
  • 56 (a)
OneToOne
trappc12 35
  • 64.27 (n)
  • 62.33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011533 35
  • 24.04 (n)
  • 5.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11396 36
  • 35 (a)
OneToOne
CG11396 35
  • 50.13 (n)
  • 40.9 (a)
worm
(Caenorhabditis elegans)
Secernentea trpp-12 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39820 35
  • 46.03 (n)
  • 34.88 (a)
rice
(Oryza sativa)
Liliopsida Os02g0550400 35
  • 46.01 (n)
  • 32.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
CSA.736 36
  • 42 (a)
OneToMany
Species with no ortholog for TRAPPC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC12 Gene

ENSEMBL:
Gene Tree for TRAPPC12 (if available)
TreeFam:
Gene Tree for TRAPPC12 (if available)

Paralogs for TRAPPC12 Gene

genes like me logo Genes that share paralogs with TRAPPC12: view

No data available for Paralogs for TRAPPC12 Gene

Variants for TRAPPC12 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11686212 - 3,388,524(+) GCATG(A/G)GCGAG nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_035869 A breast cancer sample
rs6767 -- 3,479,434(-) GTGTT(A/G)AAGCT nc-transcript-variant, reference, synonymous-codon
rs1132171 -- 3,421,958(+) AAGAG(C/T)GGGCT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs4404310 -- 3,472,906(+) GAAGC(A/T)TCAAG intron-variant

Variation tolerance for TRAPPC12 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.56; 97.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC12 Gene

HapMap Linkage Disequilibrium report
TRAPPC12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRAPPC12 Gene

Disorders for TRAPPC12 Gene

Relevant External Links for TRAPPC12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAPPC12

No disorders were found for TRAPPC12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAPPC12 Gene

Publications for TRAPPC12 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4 67
  2. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 2 3
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TRAPPC12 Gene

Sources for TRAPPC12 Gene

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