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Aliases for TRAPPC12 Gene

Aliases for TRAPPC12 Gene

  • Trafficking Protein Particle Complex 12 2 3
  • TTC15 3 4 6
  • Tetratricopeptide Repeat Protein 15 3 4
  • Tetratricopeptide Repeat Domain 15 2 3
  • TPR Repeat Protein 15 3 4
  • TTC-15 3 4
  • Trafficking Protein Particle Complex Subunit 12 3
  • CGI-87 3

External Ids for TRAPPC12 Gene

Previous Symbols for TRAPPC12 Gene

  • TTC15

Summaries for TRAPPC12 Gene

GeneCards Summary for TRAPPC12 Gene

TRAPPC12 (Trafficking Protein Particle Complex 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRAPPC12 Gene

  • May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC12 Gene

Genomics for TRAPPC12 Gene

Genomic Location for TRAPPC12 Gene

Start:
3,379,675 bp from pter
End:
3,485,094 bp from pter
Size:
105,420 bases
Orientation:
Plus strand

Genomic View for TRAPPC12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC12 Gene

No data available for Regulatory Elements for TRAPPC12 Gene

Proteins for TRAPPC12 Gene

  • Protein details for TRAPPC12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVT3-TPC12_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 12
    Protein Accession:
    Q8WVT3
    Secondary Accessions:
    • B3KV01
    • D6W4Y2
    • Q8WVW1
    • Q9Y395

    Protein attributes for TRAPPC12 Gene

    Size:
    735 amino acids
    Molecular mass:
    79375 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=AAD34082.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRAPPC12 Gene

Proteomics data for TRAPPC12 Gene at MOPED

Post-translational modifications for TRAPPC12 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys354, Lys364, Lys385, Lys510, and Lys601

No data available for DME Specific Peptides for TRAPPC12 Gene

Domains for TRAPPC12 Gene

Gene Families for TRAPPC12 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Protein Domains for TRAPPC12 Gene

UniProtKB/Swiss-Prot:

TPC12_HUMAN
Similarity:
  • Contains 4 TPR repeats.:
    • Q8WVT3
genes like me logo Genes that share domains with TRAPPC12: view

Function for TRAPPC12 Gene

Molecular function for TRAPPC12 Gene

UniProtKB/Swiss-Prot Function: May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Gene Ontology (GO) - Molecular Function for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IBA --
GO:0005198 structural molecule activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TRAPPC12: view

miRNA for TRAPPC12 Gene

miRTarBase miRNAs that target TRAPPC12

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC12 Gene

Localization for TRAPPC12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC12 Gene

Endoplasmic reticulum-Golgi intermediate compartment.

Gene Ontology (GO) - Cellular Components for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
genes like me logo Genes that share ontologies with TRAPPC12: view

Pathways for TRAPPC12 Gene

SuperPathways for TRAPPC12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC12: view

No data available for Pathways by source for TRAPPC12 Gene

Transcripts for TRAPPC12 Gene

Unigene Clusters for TRAPPC12 Gene

Trafficking protein particle complex 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC12 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12: -

ExUns: 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRAPPC12 Gene

GeneLoc Exon Structure for
TRAPPC12
ECgene alternative splicing isoforms for
TRAPPC12

Expression for TRAPPC12 Gene

mRNA expression in normal human tissues for TRAPPC12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC12 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC12 Gene Hs.252713

genes like me logo Genes that share expressions with TRAPPC12: view

Orthologs for TRAPPC12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TTC15 36
  • 99.14 (n)
  • 99.18 (a)
TTC15 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TTC15 36
  • 78.54 (n)
  • 77.17 (a)
TTC15 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC12 36
  • 78.37 (n)
  • 78.55 (a)
TRAPPC12 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc12 36
  • 76.64 (n)
  • 79.32 (a)
Trappc12 16
Trappc12 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC12 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC12 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc12 36
  • 77.88 (n)
  • 79.56 (a)
chicken
(Gallus gallus)
Aves TRAPPC12 36
  • 69.65 (n)
  • 75.53 (a)
TRAPPC12 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC12 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25574 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4089 36
trappc12 36
  • 67 (n)
  • 68.97 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc12 36
  • 64.27 (n)
  • 62.33 (a)
trappc12 37
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011533 36
  • 24.04 (n)
  • 5.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11396 36
  • 50.13 (n)
  • 40.9 (a)
CG11396 37
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpp-12 37
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G39820 36
  • 46.03 (n)
  • 34.88 (a)
rice
(Oryza sativa)
Liliopsida Os02g0550400 36
  • 46.01 (n)
  • 32.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
CSA.736 37
  • 42 (a)
OneToMany
Species with no ortholog for TRAPPC12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC12 Gene

ENSEMBL:
Gene Tree for TRAPPC12 (if available)
TreeFam:
Gene Tree for TRAPPC12 (if available)

Paralogs for TRAPPC12 Gene

Selected SIMAP similar genes for TRAPPC12 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with TRAPPC12: view

No data available for Paralogs for TRAPPC12 Gene

Variants for TRAPPC12 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6767 -- 3,479,434(-) GTGTT(A/G)AAGCT reference, synonymous-codon, nc-transcript-variant
rs13986 -- 3,479,410(-) CCGGC(A/G)ACAGC reference, synonymous-codon, nc-transcript-variant
rs1132171 -- 3,421,958(+) AAGAG(C/T)GGGCT reference, synonymous-codon, downstream-variant-500B, nc-transcript-variant
rs1137842 -- 3,472,526(+) AGAGC(A/G)TCCTC intron-variant
rs2324567 -- 3,382,875(+) agcca(C/T)catcg intron-variant

Relevant External Links for TRAPPC12 Gene

HapMap Linkage Disequilibrium report
TRAPPC12

No data available for Structural Variations from Database of Genomic Variants (DGV) for TRAPPC12 Gene

Disorders for TRAPPC12 Gene

No disorders were found for TRAPPC12 Gene.

No data available for UniProtKB/Swiss-Prot for TRAPPC12 Gene

Publications for TRAPPC12 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAPPC12 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRAPPC12
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC12
    • Block miRNA regulation of TRAPPC12 using miScript Target Protectors

    Sources for TRAPPC12 Gene

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