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Aliases for TRAPPC11 Gene

Aliases for TRAPPC11 Gene

  • Trafficking Protein Particle Complex 11 2 3
  • C4orf41 3 4 6
  • LGMD2S 3 6
  • Trafficking Protein Particle Complex Subunit 11 3
  • Chromosome 4 Open Reading Frame 41 2
  • Foie Gras Homolog (Zebrafish) 2
  • Gryzun Homolog (Drosophila) 2
  • Foie Gras Homolog 3
  • Gryzun Homolog 3
  • FOIGR 3
  • GRY 3

External Ids for TRAPPC11 Gene

Previous HGNC Symbols for TRAPPC11 Gene

  • C4orf41

Previous GeneCards Identifiers for TRAPPC11 Gene

  • GC04P184581

Summaries for TRAPPC11 Gene

Entrez Gene Summary for TRAPPC11 Gene

  • The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRAPPC11 Gene

TRAPPC11 (Trafficking Protein Particle Complex 11) is a Protein Coding gene. Diseases associated with TRAPPC11 include muscular dystrophy, limb-girdle, type 2e and intellectual disability-hyperkinetic movement-truncal ataxia syndrome.

UniProtKB/Swiss-Prot for TRAPPC11 Gene

  • Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC11 Gene

Genomics for TRAPPC11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAPPC11 Gene

Start:
183,659,267 bp from pter
End:
183,713,594 bp from pter
Size:
54,328 bases
Orientation:
Plus strand

Genomic View for TRAPPC11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC11 Gene

No data available for Regulatory Elements for TRAPPC11 Gene

Proteins for TRAPPC11 Gene

  • Protein details for TRAPPC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z392-TPC11_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 11
    Protein Accession:
    Q7Z392
    Secondary Accessions:
    • A4QPB8
    • B2RCD6
    • Q5U5I7
    • Q6FI73
    • Q86T25
    • Q9H0L1
    • Q9H5K9
    • Q9H8Q1
    • Q9H9I7

    Protein attributes for TRAPPC11 Gene

    Size:
    1133 amino acids
    Molecular mass:
    128881 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=BAB14240.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15617.1; Type=Erroneous termination; Positions=1063; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAG37533.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66686.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD91169.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97983.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC11 Gene

Proteomics data for TRAPPC11 Gene at MOPED

Post-translational modifications for TRAPPC11 Gene

  • Ubiquitination at Lys898 and Lys1119
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC11 Gene

No data available for DME Specific Peptides for TRAPPC11 Gene

Domains for TRAPPC11 Gene

Gene Families for TRAPPC11 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC11 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z392

UniProtKB/Swiss-Prot:

TPC11_HUMAN :
  • Q7Z392
Family:
  • Belongs to the TRAPPC11 family.
genes like me logo Genes that share domains with TRAPPC11: view

No data available for Suggested Antigen Peptide Sequences for TRAPPC11 Gene

Function for TRAPPC11 Gene

Molecular function for TRAPPC11 Gene

UniProtKB/Swiss-Prot Function: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Animal Model Products

CRISPR Products

miRNA for TRAPPC11 Gene

miRTarBase miRNAs that target TRAPPC11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC11 Gene

Localization for TRAPPC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC11 Gene

Golgi apparatus, cis-Golgi network.

Gene Ontology (GO) - Cellular Components for TRAPPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with TRAPPC11: view

No data available for Subcellular locations from COMPARTMENTS for TRAPPC11 Gene

Pathways for TRAPPC11 Gene

SuperPathways for TRAPPC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with TRAPPC11: view

No data available for Pathways by source for TRAPPC11 Gene

Transcripts for TRAPPC11 Gene

Unigene Clusters for TRAPPC11 Gene

Trafficking protein particle complex 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRAPPC11
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for TRAPPC11 Gene

GeneLoc Exon Structure for
TRAPPC11
ECgene alternative splicing isoforms for
TRAPPC11

Expression for TRAPPC11 Gene

mRNA expression in normal human tissues for TRAPPC11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC11 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC11 Gene Hs.443240

genes like me logo Genes that share expressions with TRAPPC11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC11 Gene

Orthologs for TRAPPC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC11 35
  • 99.59 (n)
  • 99.72 (a)
TRAPPC11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC11 35
  • 89.56 (n)
  • 95.32 (a)
TRAPPC11 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC11 35
  • 92.47 (n)
  • 96.2 (a)
TRAPPC11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc11 35
  • 87.2 (n)
  • 93.65 (a)
Trappc11 16
Trappc11 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC11 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trappc11 35
  • 88.17 (n)
  • 94.44 (a)
chicken
(Gallus gallus)
Aves C4H4ORF41 35
  • 79 (n)
  • 88.78 (a)
C4H4ORF41 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC11 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16501 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7134 35
trappc11 35
  • 76.29 (n)
  • 85.53 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc11 35
  • 71 (n)
  • 78.62 (a)
trappc11 36
  • 79 (a)
OneToOne
wufb78g05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006517 35
  • 44.55 (n)
  • 36.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta gry 35
  • 47.41 (n)
  • 37.41 (a)
gry 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0412.3 35
  • 46.2 (n)
  • 35.89 (a)
trpp-11 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65950 35
  • 42.21 (n)
  • 28.66 (a)
rice
(Oryza sativa)
Liliopsida Os02g0714500 35
  • 43.94 (n)
  • 32.31 (a)
Species with no ortholog for TRAPPC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC11 Gene

ENSEMBL:
Gene Tree for TRAPPC11 (if available)
TreeFam:
Gene Tree for TRAPPC11 (if available)

Paralogs for TRAPPC11 Gene

No data available for Paralogs for TRAPPC11 Gene

Variants for TRAPPC11 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4241779 -- 183,679,448(+) AGTGC(A/G)GAGCT reference, synonymous-codon
rs4282227 -- 183,666,968(+) ATCTT(C/T)GGTTG intron-variant
rs4286581 -- 183,699,987(+) CGCCC(A/G)GCTAA intron-variant
rs4321675 -- 183,707,650(+) CTAAT(C/T)AACTG intron-variant
rs4374653 -- 183,700,859(+) atttt(C/T)atttt intron-variant

Relevant External Links for TRAPPC11 Gene

HapMap Linkage Disequilibrium report
TRAPPC11
Human Gene Mutation Database (HGMD)
TRAPPC11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRAPPC11 Gene

Disorders for TRAPPC11 Gene

(1) OMIM Diseases for TRAPPC11 Gene (614138)

UniProtKB/Swiss-Prot

TPC11_HUMAN
  • Limb-girdle muscular dystrophy 2S (LGMD2S) [MIM:615356]: A form of limb-girdle muscular dystrophy characterized by proximal muscle weakness with childhood onset, resulting in gait abnormalities and scapular winging. Serum creatine kinase is increased. A subset of patients may show a hyperkinetic movement disorder with chorea, ataxia, or dystonia and global developmental delay. {ECO:0000269 PubMed:23830518}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with TRAPPC11: view

Publications for TRAPPC11 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4
  2. Recessive TRAPPC11 mutations cause a disease spectrum of limb girdle muscular dystrophy and myopathy with movement disorder and intellectual disability. (PMID: 23830518) BAPgershausen N. … Lamont R.E. (Am. J. Hum. Genet. 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PMID: 19942856) Wendler F. … Munro S. (EMBO J. 2010) 2 3

Products for TRAPPC11 Gene

Sources for TRAPPC11 Gene

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