Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAPPC11 Gene

Aliases for TRAPPC11 Gene

  • Trafficking Protein Particle Complex 11 2 3 5
  • C4orf41 3 4
  • Chromosome 4 Open Reading Frame 41 2
  • Foie Gras Homolog (Zebrafish) 2
  • Gryzun Homolog (Drosophila) 2
  • Foie Gras Homolog 3
  • Gryzun Homolog 3
  • LGMD2S 3
  • FOIGR 3
  • GRY 3

External Ids for TRAPPC11 Gene

Previous HGNC Symbols for TRAPPC11 Gene

  • C4orf41

Previous GeneCards Identifiers for TRAPPC11 Gene

  • GC04P184581

Summaries for TRAPPC11 Gene

Entrez Gene Summary for TRAPPC11 Gene

  • The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, which functions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgi vesicle transport. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRAPPC11 Gene

TRAPPC11 (Trafficking Protein Particle Complex 11) is a Protein Coding gene. Diseases associated with TRAPPC11 include Muscular Dystrophy, Limb-Girdle, Type 2E and Intellectual Disability-Hyperkinetic Movement-Truncal Ataxia Syndrome.

UniProtKB/Swiss-Prot for TRAPPC11 Gene

  • Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC11 Gene

Genomics for TRAPPC11 Gene

Regulatory Elements for TRAPPC11 Gene

Enhancers for TRAPPC11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC11 on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC11 Gene

183,659,267 bp from pter
183,713,594 bp from pter
54,328 bases
Plus strand

Genomic View for TRAPPC11 Gene

Genes around TRAPPC11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC11 Gene

Proteins for TRAPPC11 Gene

  • Protein details for TRAPPC11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 11
    Protein Accession:
    Secondary Accessions:
    • A4QPB8
    • B2RCD6
    • Q5U5I7
    • Q6FI73
    • Q86T25
    • Q9H0L1
    • Q9H5K9
    • Q9H8Q1
    • Q9H9I7

    Protein attributes for TRAPPC11 Gene

    1133 amino acids
    Molecular mass:
    128881 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    • Sequence=BAB14240.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15617.1; Type=Erroneous termination; Positions=1063; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=BAG37533.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66686.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD91169.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD97983.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC11 Gene


neXtProt entry for TRAPPC11 Gene

Proteomics data for TRAPPC11 Gene at MOPED

Post-translational modifications for TRAPPC11 Gene

  • Ubiquitination at Lys 898 and Lys 1119
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAPPC11 Gene

No data available for DME Specific Peptides for TRAPPC11 Gene

Domains & Families for TRAPPC11 Gene

Gene Families for TRAPPC11 Gene

Protein Domains for TRAPPC11 Gene

Suggested Antigen Peptide Sequences for TRAPPC11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRAPPC11 family.
  • Belongs to the TRAPPC11 family.
genes like me logo Genes that share domains with TRAPPC11: view

Function for TRAPPC11 Gene

Molecular function for TRAPPC11 Gene

UniProtKB/Swiss-Prot Function:
Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.

Phenotypes for TRAPPC11 Gene

GenomeRNAi human phenotypes for TRAPPC11:
genes like me logo Genes that share phenotypes with TRAPPC11: view

Human Phenotype Ontology for TRAPPC11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TRAPPC11 Gene

miRTarBase miRNAs that target TRAPPC11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC11 Gene

Localization for TRAPPC11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC11 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

Jensen Localization Image for TRAPPC11 Gene COMPARTMENTS Subcellular localization image for TRAPPC11 gene
Compartment Confidence
golgi apparatus 3
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TRAPPC11 Gene

Pathways & Interactions for TRAPPC11 Gene

SuperPathways for TRAPPC11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC11 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAPPC11 Gene

Drugs & Compounds for TRAPPC11 Gene

No Compound Related Data Available

Transcripts for TRAPPC11 Gene

Unigene Clusters for TRAPPC11 Gene

Trafficking protein particle complex 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - -

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c
SP1: - - -
SP2: - - -
SP3: - -

Relevant External Links for TRAPPC11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC11 Gene

mRNA expression in normal human tissues for TRAPPC11 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC11 Gene

This gene is overexpressed in Stomach (7.0) and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC11 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC11 Gene Hs.443240

genes like me logo Genes that share expression patterns with TRAPPC11: view

Protein tissue co-expression partners for TRAPPC11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAPPC11 Gene

Orthologs for TRAPPC11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRAPPC11 35
  • 89.56 (n)
  • 95.32 (a)
  • 95 (a)
(Canis familiaris)
Mammalia TRAPPC11 35
  • 92.47 (n)
  • 96.2 (a)
  • 96 (a)
(Mus musculus)
Mammalia Trappc11 35
  • 87.2 (n)
  • 93.65 (a)
Trappc11 16
Trappc11 36
  • 94 (a)
(Pan troglodytes)
Mammalia TRAPPC11 35
  • 99.59 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Trappc11 35
  • 88.17 (n)
  • 94.44 (a)
(Monodelphis domestica)
Mammalia TRAPPC11 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
-- 36
  • 85 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves C4H4ORF41 35
  • 79 (n)
  • 88.78 (a)
C4H4ORF41 36
  • 89 (a)
(Anolis carolinensis)
Reptilia TRAPPC11 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7134 35
trappc11 35
  • 76.29 (n)
  • 85.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16501 35
(Danio rerio)
Actinopterygii trappc11 35
  • 71 (n)
  • 78.62 (a)
wufb78g05 35
trappc11 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006517 35
  • 44.55 (n)
  • 36.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta gry 35
  • 47.41 (n)
  • 37.41 (a)
gry 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea B0412.3 35
  • 46.2 (n)
  • 35.89 (a)
trpp-11 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65950 35
  • 42.21 (n)
  • 28.66 (a)
(Oryza sativa)
Liliopsida Os02g0714500 35
  • 43.94 (n)
  • 32.31 (a)
Species with no ortholog for TRAPPC11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC11 Gene

Gene Tree for TRAPPC11 (if available)
Gene Tree for TRAPPC11 (if available)

Paralogs for TRAPPC11 Gene

No data available for Paralogs for TRAPPC11 Gene

Variants for TRAPPC11 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC11 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_070158 Limb-girdle muscular dystrophy 2S (LGMD2S)
rs4241779 -- 183,679,448(+) AGTGC(A/G)GAGCT reference, synonymous-codon
rs4282227 -- 183,666,968(+) ATCTT(C/T)GGTTG intron-variant
rs4286581 -- 183,699,987(+) CGCCC(A/G)GCTAA intron-variant
rs4467621 -- 183,700,108(+) CGCCC(A/G)GCCAA intron-variant

Variation tolerance for TRAPPC11 Gene

Residual Variation Intolerance Score: 5.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.72; 86.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAPPC11 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRAPPC11 Gene

Disorders for TRAPPC11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRAPPC11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and DISEASES

Disorder Aliases PubMed IDs
muscular dystrophy, limb-girdle, type 2e
  • muscular dystrophy, limb-girdle, type 2s
intellectual disability-hyperkinetic movement-truncal ataxia syndrome
episodic ataxia, type 2
  • episodic ataxia type 2
- elite association - COSMIC cancer census association via MalaCards


  • Limb-girdle muscular dystrophy 2S (LGMD2S) [MIM:615356]: A form of limb-girdle muscular dystrophy characterized by proximal muscle weakness with childhood onset, resulting in gait abnormalities and scapular winging. Serum creatine kinase is increased. A subset of patients may show a hyperkinetic movement disorder with chorea, ataxia, or dystonia and global developmental delay. {ECO:0000269 PubMed:23830518}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRAPPC11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRAPPC11: view

No data available for Genatlas for TRAPPC11 Gene

Publications for TRAPPC11 Gene

  1. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens P.J. … Sacher M. (Mol. Biol. Cell 2011) 2 3 4 67
  2. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PMID: 19942856) Wendler F. … Munro S. (EMBO J. 2010) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TRAPPC11 Gene

Sources for TRAPPC11 Gene