TRAPPC11 Gene
protein-coding GIFtS: 41
GCID: GC04P184581
|
|
trafficking protein particle complex 11(Previous name: chromosome 4 open reading frame 41 )
(Previous symbol: C4orf41)
| |
Aliases
for TRAPPC11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Trafficking Protein Particle Complex 111 2 | | FOIGR2 | | C4orf411 2 3 | | GRY2 | | FLJ127161 | | Foie Gras Homolog2 | | Chromosome 4 Open Reading Frame 411 | | Gryzun Homolog2 | | Foigr1 | | Trafficking Protein Particle Complex Subunit 112 | | Gry1 | | |
Export aliases for TRAPPC11 gene to outside databases |
Summaries
for TRAPPC11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRAPPC11:
The protein encoded by this gene is a subunit of the TRAPP (transport protein particle) tethering complex, whichfunctions in intracellular vesicle trafficking. This subunit is involved in early stage endoplasmic reticulum-to-Golgivesicle transport. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan2013)
UniProtKB/Swiss-Prot: TPC11_HUMAN, Q7Z392Function: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage
|
Genomic Views
for TRAPPC11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRAPPC11
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRAPPC11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAPPC11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1TRAPPC11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P184581: view genomic region
(about GC identifiers)
Start:
|
184,580,420 bp from pter |
End:
|
184,634,745 bp from pter |
Size:
|
54,326 bases |
Orientation:
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plus strand |
|
Proteins
for TRAPPC11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TPC11_HUMAN, Q7Z392 (See
protein sequence)Recommended Name: Trafficking protein particle complex subunit 11 Size: 1133 amino acids; 128881 Da
Subunit: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2,TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Subcellular location: Golgi apparatus, cis-Golgi network (By similarity)
Sequence caution: Sequence=BAB14240.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB14556.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15617.1;Type=Erroneous termination; Positions=1063; Note=Translated as Gln; Sequence=BAG37533.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=CAB66686.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=CAD91169.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=CAD97983.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4QPB8 B2RCD6 Q5U5I7 Q6FI73 Q86T25 Q9H0L1 Q9H5K9 Q9H8Q1 Q9H9I7Alternative splicing: 4 isoforms: Q7Z392-1 Q7Z392-2 Q7Z392-3 Q7Z392-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRAPPC11: NX_Q7Z392
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z392
TRAPPC11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_068761.4 NP_951008.1
ENSEMBL proteins: ENSP00000335371 ENSP00000422915 ENSP00000421004 ENSP00000349738
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005794 | Golgi apparatus |
IEA | -- |
TRAPPC11 for ontologies About GeneDecksing
TRAPPC11 Antibody Products:
Assay Products for TRAPPC11: |
Protein
Domains /
Families
for TRAPPC11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRAPPC11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z392ProtoNet protein and cluster: Q7Z392 1 Blocks protein family: IPB012880 Protein of unknown function DUF1683
UniProtKB/Swiss-Prot: TPC11_HUMAN, Q7Z392Similarity: Belongs to the TRAPPC11 family |
Function
for TRAPPC11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TPC11_HUMAN, Q7Z392Function: Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAPPC11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAPPC11 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC11 |
|
Pathways & Interactions
for TRAPPC11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAPPC11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/9 Interacting proteins for TRAPPC11 (Q7Z3923 ENSP000003353714) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016192 | vesicle-mediated transport |
IEA | -- |
TRAPPC11 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRAPPC11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRAPPC11
Search CenterWatch for drugs/clinical trials and news about TRAPPC11 / TPC11
|
Transcripts
for TRAPPC11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRAPPC11 gene (2 alternative transcripts): NM_021942.5 NM_199053.2 Unigene Cluster for TRAPPC11: Trafficking protein particle complex 11 Hs.443240 [show with all ESTs]Unigene Representative Sequence: BX64712710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000334690(uc003ivw.3 uc003ivx.3 uc010isc.3 uc003ivy.3)
ENST00000504526 ENST00000505676 ENST00000509857 ENST00000513600 ENST00000511409
ENST00000512476 ENST00000511955 ENST00000506426 ENST00000357207
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAPPC11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAPPC11 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TRAPPC11 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAPPC11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAPPC11 |
Additional cDNA sequence: AK022778.1 AK023390.1 AK091146.1 AK096345.1 AK315057.1 AL133076.1 AL136752.1 AL833451.1 AL833571.1 BC040530.1 BC051724.1 BC139745.1 BX538044.1 BX647127.1 BX648499.1 CR533553.1 14 DOTS entries: DT.455991 DT.100026270 DT.95332621 DT.100787777 DT.102826380 DT.95307123 DT.121256866 DT.121256906 DT.121256929 DT.75142226 DT.92427946 DT.75157901 DT.75190141 DT.99966811 24/181 AceView cDNA sequences (see all 181): BG496357 BU686638 CA432068 AI276908 Z38610 AA305309 BC022185 AI983506 Z42403 BQ447993 AK090489 CB128173 AW195145 AI915091 AW080504 AW074026 AA954759 AI081245 BM997140 AA732462 AA916669 AU139476 BQ223021 BX647127
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC11 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | · | 32c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRAPPC11
|
Expression
for TRAPPC11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRAPPC11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TRAPPC11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAPPC11
SOURCE GeneReport for Unigene cluster: Hs.443240
SABiosciences Custom PCR Arrays for TRAPPC11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAPPC11
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRAPPC11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAPPC11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC11 |
Orthologs
for TRAPPC11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRAPPC11 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for TRAPPC11 (if available)
TreeFam Gene Tree for TRAPPC11 (if available) |
Paralogs
for TRAPPC11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TRAPPC11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAPPC11 |
|
Disorders
/ Diseases
for TRAPPC11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRAPPC11 for disorders About MalaCards
TRAPPC11 for disorders About GeneDecksing
OMIM gene information: 614138
OMIM disorders: --
Export disorders for TRAPPC11 gene to outside databases
|
Publications
for TRAPPC11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRAPPC11 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TRAPPC11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- C4orf41 and TTC-15 are mammalian TRAPP components wit h a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2, 3 Scrivens P.J....Sacher M. (2011)
- A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PubMed id 19942856)1, 3 Wendler F....Munro S. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A trapper keeper for TRAPP, its structures and functio ns. (PubMed id 22669257)1 Yu S. and Liang Y. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A genome-scale protein interaction profile of Drosoph ila p53 uncovers additional nodes of the human p53 network. (PubMed id 20308539)1 Lunardi A....Collavin L. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
|
External Searches for TRAPPC11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRAPPC11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRAPPC11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRAPPC11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRAPPC11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRAPPC11 gene:
Search GeneIP for patents involving TRAPPC11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRAPPC11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TRAPPC11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC11 |
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