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TRAPPC10 Gene

protein-coding   GIFtS: 51
GCID: GC21P045432

Trafficking Protein Particle Complex 10

(Previous name: transmembrane protein 1)
(Previous symbol: TMEM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Trafficking Protein Particle Complex 101 2     EHOC-12 3
TMEM11 2 3 5     TRAPP Subunit TMEM12 3
EHOC12 3 5     GT3342
Transmembrane Protein 11 2     TRS1302
Trafficking Protein Particle Complex Subunit 1301 2     TRS302
TRAPP 130 KDa Subunit1 2     Epilepsy Holoprosencephaly Candidate-1 Protein2
Epilepsy Holoprosencephaly Candidate 1 Protein2 3     Trafficking Protein Particle Complex Subunit 102
Trafficking Protein Particle Complex Subunit TMEM12 3     Protein GT3343
Transport Protein Particle Subunit TMEM12 3     

External Ids:    HGNC: 118681   Entrez Gene: 71092   Ensembl: ENSG000001602187   OMIM: 6021035   UniProtKB: P485533   

Export aliases for TRAPPC10 gene to outside databases

Previous GC identifers: GC00U913620 GC21P044257 GC21P030802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAPPC10 Gene:
The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is
part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport
from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the
Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRAPPC10 Gene:
TRAPPC10 (trafficking protein particle complex 10) is a protein-coding gene. Diseases associated with TRAPPC10 include cranial nerve palsy, and myoclonus epilepsy. GO annotations related to this gene include sodium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot: TPC10_HUMAN, P48553
Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC10 (TMEM1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAPPC10 gene promoter:
         AhR   TBP   Pax-5   E47   c-Ets-1   CREB   TFIID   Hand1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAPPC10 promoter sequence
   Search Chromatin IP Primers for TRAPPC10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAPPC10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

TRAPPC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAPPC10 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P045432:  view genomic region     (about GC identifiers)

Start:
45,432,200 bp from pter      End:
45,526,433 bp from pter
Size:
94,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TPC10_HUMAN, P48553 (See protein sequence)
Recommended Name: Trafficking protein particle complex subunit 10  
Size: 1259 amino acids; 142189 Da
Subunit: Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least
TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12
Sequence caution: Sequence=AAC50134.1; Type=Frameshift; Positions=1187;
Secondary accessions: Q3MIR2 Q9UMD4 Q9Y4L3

Explore the universe of human proteins at neXtProt for TRAPPC10: NX_P48553

Explore proteomics data for TRAPPC10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRAPPC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003265.3  
    ENSEMBL proteins: 
     ENSP00000369570   ENSP00000291574   ENSP00000402221  

    TRAPPC10 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRAPPC: Trafficking protein particle complex

    1 InterPro protein domain:
     IPR022233 TRAPP_II_complex_TRAPPC10

    Graphical View of Domain Structure for InterPro Entry P48553

    ProtoNet protein and cluster: P48553

    UniProtKB/Swiss-Prot: TPC10_HUMAN, P48553
    Similarity: Belongs to the TMEM1 family


    TRAPPC10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPC10_HUMAN, P48553
    Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0015081sodium ion transmembrane transporter activity TAS7633421
         
    TRAPPC10 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target TRAPPC10:
    hsa-mir-615-3p (MIRT040102), hsa-mir-18a-3p (MIRT040804), hsa-mir-330-5p (MIRT038240), hsa-mir-186-5p (MIRT021083), hsa-mir-193b-3p (MIRT041335)

    Block miRNA regulation of human, mouse, rat TRAPPC10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAPPC10 (see all 56):
    hsa-miR-3164 hsa-miR-323-3p hsa-miR-429 hsa-miR-106a hsa-miR-134 hsa-miR-374a hsa-miR-138-2* hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPC10_HUMAN, P48553: Golgi apparatus, cis-Golgi network (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    nucleus3
    cytosol2
    endosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0016021integral component of membrane TAS9196060

    TRAPPC10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRAPPC10
    Interactions:

        Search GeneGlobe Interaction Network for TRAPPC10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAPPC10 (P485531 ENSP000002915744) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAB3IPQ96QF01, ENSP000003680864EBI-6160572,EBI-747844 STRING: ENSP00000368086
    TRAPPC2ENSP000003527084STRING: ENSP00000352708
    TRAPPC1ENSP000003027834STRING: ENSP00000302783
    TRAPPC9ENSP000003739794STRING: ENSP00000373979
    TRAPPC5ENSP000003169904STRING: ENSP00000316990
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport TAS7633421
    GO:0016192vesicle-mediated transport IEA--
    GO:0035725sodium ion transmembrane transport TAS7633421

    TRAPPC10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAPPC10 (TPC10)

    2 Novoseek inferred chemical compound relationships for TRAPPC10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 17052222 (1), 18374905 (1)
    tyrosine 0 1 11328818 (1)



    TRAPPC10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAPPC10 gene (2 alternative transcripts): 
    NM_003274.4  NM_001001723.1  

    Unigene Cluster for TRAPPC10:

    Trafficking protein particle complex 10
    Hs.126221  [show with all ESTs]
    Unigene Representative Sequence: NM_003274
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380221(uc002zdz.3) ENST00000291574(uc002zea.3 uc010gpo.3 uc011afa.2)
    ENST00000422875 ENST00000481460 ENST00000461889 ENST00000459741(uc011afb.1)
    ENST00000465905 ENST00000483973 ENST00000486746 ENST00000469521 ENST00000485621
    ENST00000468864
    miRNA
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    Block miRNA regulation of human, mouse, rat TRAPPC10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAPPC10 (see all 56):
    hsa-miR-3164 hsa-miR-323-3p hsa-miR-429 hsa-miR-106a hsa-miR-134 hsa-miR-374a hsa-miR-138-2* hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRAPPC10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRAPPC10
    Predesigned siRNA for gene silencing in human, mouse, rat TRAPPC10
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    GenScript: all cDNA clones in your preferred vector: TRAPPC10 (NM_003274)
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    Primer
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    OriGene qPCR primer pairs and template standards for TRAPPC10
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAPPC10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAPPC10
      QuantiTect SYBR Green Assays in human, mouse, rat TRAPPC10
      QuantiFast Probe-based Assays in human, mouse, rat TRAPPC10

    Additional mRNA sequence: 

    AK295369.1 AK303570.1 AL050119.1 BC046241.1 BC052247.1 BC071569.1 BC094823.1 BC101728.1 
    U19252.1 U61500.1 

    18 DOTS entries:

    DT.214485  DT.95249289  DT.97837710  DT.92431297  DT.100022498  DT.95268746  DT.97796941  DT.100008842 
    DT.95361079  DT.445132  DT.100022499  DT.40118578  DT.40271497  DT.92431295  DT.121136220  DT.408525 
    DT.91818725  DT.91830872 

    Selected AceView cDNA sequences (see all 178):

    BC046241 BQ018536 CR597587 U19252 BQ065163 BM932028 AK095010 CA427234 
    BQ063307 AA081616 BM685058 BQ218014 AI659907 NM_003274 AA807618 BQ187270 
    NM_001001723 CA308685 BX400330 CB143638 BM466312 AI476110 BQ065041 CK300128 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC10 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^
    SP1:                    -                       -                                                                             -                 -               
    SP2:                    -                                                                                                                                       
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                            -               

    ExUns: 23 ^ 24 ^ 25
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TRAPPC10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAPPC10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGAAGGA
    TRAPPC10 Expression
    About this image


    TRAPPC10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
    TRAPPC10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAPPC10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126221

    UniProtKB/Swiss-Prot: TPC10_HUMAN, P48553
    Tissue specificity: Expressed in all tissues examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAPPC10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRAPPC10 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trappc101 , 5 trafficking protein particle complex 101, 5 84.95(n)1
    89.9(a)1
      10 (39.72 cM)5
    2161311  NM_001081055.11  NP_001074524.11 
     781867255 
    chicken
    (Gallus gallus)
    Aves TRAPPC101 trafficking protein particle complex 10 76.82(n)
    83.45(a)
      771556  XM_003640505.2  XP_003640553.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAPPC106
    trafficking protein particle complex 10
    79(a)
    1 ↔ 1
    3(136374006-136441222)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trappc101 trafficking protein particle complex 10 66.91(n)
    68.56(a)
      100489172  XM_002940976.2  XP_002941022.2 
    zebrafish
    (Danio rerio)
    Actinopterygii trappc101 trafficking protein particle complex 10 63.85(n)
    62.64(a)
      100334988  XM_002663842.2  XP_002663888.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta SIDL1 Shal Interactor of Di-Leucine Motif 45.17(n)
    33.06(a)
      41833  NM_142174.3  NP_650431.1 
    worm
    (Caenorhabditis elegans)
    Secernentea trpp-106
    Protein Y71G12A.2, isoform a (Y71G12A.2) mRNA, com...
    18(a)
    1 ↔ 1
    I(1895161-1923096) WBGene00022138


    ENSEMBL Gene Tree for TRAPPC10 (if available)
    TreeFam Gene Tree for TRAPPC10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAPPC10 (see all 2224)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880744621,2
    --30802790(+) GCCGCC/TCAGGC 1 -- ut510--------
    rs351870821,2
    C--30850403(+) GTGTC-/TTTTTT 1 -- int10--------
    rs745265071,2
    C--30884428(+) TGGGGG/TTGAAA 1 -- int10--------
    rs1156068121,2
    F--35927463(+) GCTGTG/ATTCAC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs732269801,2
    C--35927528(+) ACTTAC/TGATGC 1 -- us2k10--------
    rs755824221,2
    C,F--35927723(+) CAGGAG/AGTGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1163643671,2
    C,F--35927887(+) GGTTGC/TGTGCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1453402241,2
    --35927903(+) TGAGAA/CTCTCA 1 -- us2k10--------
    rs1835663301,2
    --35927956(+) ACCGTA/CCAGTT 1 -- us2k10--------
    rs81325641,2
    C--35928135(+) tccctG/Tgtgcc 1 -- us2k14Minor allele frequency- T:0.03NA WA 124

    HapMap Linkage Disequilibrium report for TRAPPC10 (45432200 - 45526433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRAPPC10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723627CNV Deletion23290073
    nsv913890CNV Loss21882294
    esv33817CNV Loss17666407
    dgv4765n71CNV Loss21882294
    nsv913887CNV Loss21882294
    dgv4764n71CNV Loss21882294
    esv25124CNV Gain19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602103    OMIM disorders: --

    20 diseases for TRAPPC10:    
    About MalaCards
    cranial nerve palsy    myoclonus epilepsy    progressive myoclonus epilepsy    myoclonus
    holoprosencephaly    optic atrophy    laryngeal squamous cell carcinoma    sjogren's syndrome
    laryngitis    hyperparathyroidism    astrocytoma    multiple sclerosis
    renal cell carcinoma    squamous cell carcinoma    alzheimer's disease    prostate cancer
    prostatitis    endotheliitis    cerebritis    malaria


    TRAPPC10 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for TRAPPC10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apeced 64.5 1 7633421 (1)
    alzheimers disease 18.9 1 14681887 (1)
    genetic disorder 15.7 4 9196060 (1)
    immunodeficiency 8 5 7609094 (2), 8523539 (1), 10799616 (1), 8416370 (1)
    tumors 0 1 7528667 (1)

    GeneTests: TRAPPC10
    GeneReviews: TRAPPC10
    Genetic Association Database (GAD): TRAPPC10
    Human Genome Epidemiology (HuGE) Navigator: TRAPPC10 (1 document)

    Export disorders for TRAPPC10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAPPC10 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with TRAPPC10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (PubMed id 7633421)1, 2, 3, 9 Yamakawa K.... Korenberg J.R. (Hum. Mol. Genet. 1995)
    2. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. (PubMed id 9196060)1, 2, 9 Nagamine K....Shimizu N. (Biochem. Biophys. Res. Commun. 1997)
    3. Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. (PubMed id 9370297)1, 2, 9 Lafreniere R.G....Rouleau G.A. (Gene 1997)
    4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PubMed id 21525244)1, 2 Scrivens P.J.... Sacher M. (Mol. Biol. Cell 2011)
    5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PubMed id 11805826)1, 2 Gavin A.-C....Superti-Furga G. (Nature 2002)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7109 HGNC: 11868 AceView: TMEM1 Ensembl:ENSG00000160218 euGenes: HUgn7109
    ECgene: TRAPPC10 H-InvDB: TRAPPC10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRAPPC10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRAPPC10 gene:
    Search GeneIP for patents involving TRAPPC10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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