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Aliases for TRAPPC10 Gene

Aliases for TRAPPC10 Gene

  • Trafficking Protein Particle Complex 10 2 3 5
  • Trafficking Protein Particle Complex Subunit TMEM1 3 4
  • Trafficking Protein Particle Complex Subunit 130 2 3
  • Epilepsy Holoprosencephaly Candidate 1 Protein 3 4
  • Transport Protein Particle Subunit TMEM1 3 4
  • Transmembrane Protein 1 2 3
  • TRAPP 130 KDa Subunit 2 3
  • TRAPP Subunit TMEM1 3 4
  • EHOC-1 3 4
  • TMEM1 3 4
  • EHOC1 3 4
  • Epilepsy Holoprosencephaly Candidate-1 Protein 3
  • Protein GT334 4
  • TRS130 3
  • GT334 3
  • TRS30 3

External Ids for TRAPPC10 Gene

Previous HGNC Symbols for TRAPPC10 Gene

  • TMEM1

Previous GeneCards Identifiers for TRAPPC10 Gene

  • GC00U913620
  • GC21P044257
  • GC21P045432
  • GC21P030802

Summaries for TRAPPC10 Gene

Entrez Gene Summary for TRAPPC10 Gene

  • The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAPPC10 Gene

TRAPPC10 (Trafficking Protein Particle Complex 10) is a Protein Coding gene. Diseases associated with TRAPPC10 include Progressive Myoclonus Epilepsy and Myoclonus Epilepsy. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include sodium ion transmembrane transporter activity. An important paralog of this gene is LOC102724200.

UniProtKB/Swiss-Prot for TRAPPC10 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Wiki entry for TRAPPC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC10 Gene

Genomics for TRAPPC10 Gene

Regulatory Elements for TRAPPC10 Gene

Enhancers for TRAPPC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRAPPC10 on UCSC Golden Path with GeneCards custom track

Promoters for TRAPPC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAPPC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAPPC10 Gene

44,012,319 bp from pter
44,106,552 bp from pter
94,234 bases
Plus strand

Genomic View for TRAPPC10 Gene

Genes around TRAPPC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC10 Gene

Proteins for TRAPPC10 Gene

  • Protein details for TRAPPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 10
    Protein Accession:
    Secondary Accessions:
    • Q3MIR2
    • Q86SI7
    • Q9UMD4
    • Q9Y4L3

    Protein attributes for TRAPPC10 Gene

    1259 amino acids
    Molecular mass:
    142189 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    • Sequence=AAC50134.1; Type=Frameshift; Positions=1187; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC10 Gene


neXtProt entry for TRAPPC10 Gene

Proteomics data for TRAPPC10 Gene at MOPED

Post-translational modifications for TRAPPC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAPPC10 Gene

Domains & Families for TRAPPC10 Gene

Gene Families for TRAPPC10 Gene

Protein Domains for TRAPPC10 Gene


Suggested Antigen Peptide Sequences for TRAPPC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM1 family.
  • Belongs to the TMEM1 family.
genes like me logo Genes that share domains with TRAPPC10: view

Function for TRAPPC10 Gene

Molecular function for TRAPPC10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
genes like me logo Genes that share phenotypes with TRAPPC10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAPPC10 Gene

Localization for TRAPPC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC10 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

Jensen Localization Image for TRAPPC10 Gene COMPARTMENTS Subcellular localization image for TRAPPC10 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endosome 4
nucleus 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRAPPC10: view

Pathways & Interactions for TRAPPC10 Gene

genes like me logo Genes that share pathways with TRAPPC10: view

Gene Ontology (GO) - Biological Process for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport TAS 7633421
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0034498 early endosome to Golgi transport IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with TRAPPC10: view

No data available for SIGNOR curated interactions for TRAPPC10 Gene

Drugs & Compounds for TRAPPC10 Gene

(2) Drugs for TRAPPC10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRAPPC10: view

Transcripts for TRAPPC10 Gene

Unigene Clusters for TRAPPC10 Gene

Trafficking protein particle complex 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^
SP1: - - - -
SP2: -
SP3: -
SP5: -

ExUns: 23 ^ 24 ^ 25

Relevant External Links for TRAPPC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC10 Gene

mRNA expression in normal human tissues for TRAPPC10 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC10 Gene

This gene is overexpressed in Urine (14.7), Peripheral blood mononuclear cells (10.8), and Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC10 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC10 Gene Hs.126221

mRNA Expression by UniProt/SwissProt for TRAPPC10 Gene

Tissue specificity: Expressed in all tissues examined.
genes like me logo Genes that share expression patterns with TRAPPC10: view

Protein tissue co-expression partners for TRAPPC10 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TRAPPC10 Gene

Orthologs for TRAPPC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRAPPC10 35
  • 86.18 (n)
  • 90.31 (a)
  • 89 (a)
(Canis familiaris)
Mammalia TRAPPC10 35
  • 87.66 (n)
  • 91.18 (a)
  • 91 (a)
(Mus musculus)
Mammalia Trappc10 35
  • 84.95 (n)
  • 89.9 (a)
Trappc10 16
Trappc10 36
  • 90 (a)
(Pan troglodytes)
Mammalia TRAPPC10 35
  • 99.52 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Trappc10 35
  • 84.38 (n)
  • 89.36 (a)
(Monodelphis domestica)
Mammalia TRAPPC10 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia TRAPPC10 36
  • 86 (a)
(Gallus gallus)
Aves TRAPPC10 35
  • 76.82 (n)
  • 83.45 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia TRAPPC10 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc10 35
  • 66.91 (n)
  • 68.56 (a)
(Danio rerio)
Actinopterygii trappc10 35
  • 63.85 (n)
  • 62.64 (a)
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002242 35
  • 47.37 (n)
  • 34.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIDL 35
  • 45.17 (n)
  • 33.06 (a)
  • 31 (a)
(Caenorhabditis elegans)
Secernentea trpp-10 36
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS130 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for TRAPPC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC10 Gene

Gene Tree for TRAPPC10 (if available)
Gene Tree for TRAPPC10 (if available)

Paralogs for TRAPPC10 Gene

Paralogs for TRAPPC10 Gene

genes like me logo Genes that share paralogs with TRAPPC10: view

Variants for TRAPPC10 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC10 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_009514 -
rs915877 - 44,082,963(+) AGCAT(G/T)GAGAA nc-transcript-variant, reference, missense
rs2071152 - 44,083,240(+) CCCAC(A/G)TGCTG nc-transcript-variant, reference, missense
rs1131999 -- 44,086,938(+) AGGGC(C/T)GTGGT nc-transcript-variant, reference, synonymous-codon
rs2255016 -- 44,053,792(+) GGGGG(G/T)ATCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC10 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913887 CNV Loss 21882294
nsv913890 CNV Loss 21882294
dgv4764n71 CNV Loss 21882294
dgv4765n71 CNV Loss 21882294
esv25124 CNV Gain 19812545
esv2723627 CNV Deletion 23290073

Variation tolerance for TRAPPC10 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.72; 83.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRAPPC10 Gene

Disorders for TRAPPC10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAPPC10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
progressive myoclonus epilepsy
  • unverricht-lundborg syndrome
myoclonus epilepsy
  • epilepsies, myoclonic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRAPPC10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRAPPC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC10 Gene

Publications for TRAPPC10 Gene

  1. Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (PMID: 7633421) Yamakawa K. … Korenberg J.R. (Hum. Mol. Genet. 1995) 2 3 4 23 67
  2. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. (PMID: 9196060) Nagamine K. … Shimizu N. (Biochem. Biophys. Res. Commun. 1997) 3 23
  3. Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. (PMID: 9370297) Lafreniere R.G. … Rouleau G.A. (Gene 1997) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. (PMID: 25011556) Wagner T.A. … Frenkel L.M. (Science 2014) 3

Products for TRAPPC10 Gene

Sources for TRAPPC10 Gene