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Aliases for TRAPPC10 Gene

Aliases for TRAPPC10 Gene

  • Trafficking Protein Particle Complex 10 2 3
  • TMEM1 3 4 6
  • EHOC1 3 4 6
  • Trafficking Protein Particle Complex Subunit TMEM1 3 4
  • Trafficking Protein Particle Complex Subunit 130 2 3
  • Epilepsy Holoprosencephaly Candidate 1 Protein 3 4
  • Transport Protein Particle Subunit TMEM1 3 4
  • Transmembrane Protein 1 2 3
  • TRAPP 130 KDa Subunit 2 3
  • TRAPP Subunit TMEM1 3 4
  • EHOC-1 3 4
  • Trafficking Protein Particle Complex Subunit 10 3
  • Epilepsy Holoprosencephaly Candidate-1 Protein 3
  • Protein GT334 4
  • TRS130 3
  • GT334 3
  • TRS30 3

External Ids for TRAPPC10 Gene

Previous HGNC Symbols for TRAPPC10 Gene

  • TMEM1

Previous GeneCards Identifiers for TRAPPC10 Gene

  • GC00U913620
  • GC21P044257
  • GC21P045432
  • GC21P030802

Summaries for TRAPPC10 Gene

Entrez Gene Summary for TRAPPC10 Gene

  • The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAPPC10 Gene

TRAPPC10 (Trafficking Protein Particle Complex 10) is a Protein Coding gene. Diseases associated with TRAPPC10 include holoprosencephaly. GO annotations related to this gene include sodium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for TRAPPC10 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Wiki entry for TRAPPC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC10 Gene

Genomics for TRAPPC10 Gene

Regulatory Elements for TRAPPC10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAPPC10 Gene

Start:
44,012,319 bp from pter
End:
44,106,552 bp from pter
Size:
94,234 bases
Orientation:
Plus strand

Genomic View for TRAPPC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC10 Gene

Proteins for TRAPPC10 Gene

  • Protein details for TRAPPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48553-TPC10_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 10
    Protein Accession:
    P48553
    Secondary Accessions:
    • Q3MIR2
    • Q86SI7
    • Q9UMD4
    • Q9Y4L3

    Protein attributes for TRAPPC10 Gene

    Size:
    1259 amino acids
    Molecular mass:
    142189 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    SequenceCaution:
    • Sequence=AAC50134.1; Type=Frameshift; Positions=1187; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAPPC10 Gene

Proteomics data for TRAPPC10 Gene at MOPED

Post-translational modifications for TRAPPC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAPPC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAPPC10 Gene

Domains for TRAPPC10 Gene

Gene Families for TRAPPC10 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAPPC10 Gene

Graphical View of Domain Structure for InterPro Entry

P48553

UniProtKB/Swiss-Prot:

TPC10_HUMAN :
  • P48553
Family:
  • Belongs to the TMEM1 family.
genes like me logo Genes that share domains with TRAPPC10: view

Function for TRAPPC10 Gene

Molecular function for TRAPPC10 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO) - Molecular Function for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21273506
GO:0015081 sodium ion transmembrane transporter activity TAS 7633421
genes like me logo Genes that share ontologies with TRAPPC10: view

Animal Model Products

CRISPR Products

miRNA for TRAPPC10 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC10 Gene

Localization for TRAPPC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC10 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC10 Gene COMPARTMENTS Subcellular localization image for TRAPPC10 gene
Compartment Confidence
golgi apparatus 3
nucleus 3
cytosol 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane TAS 9196060
GO:1990071 TRAPPII protein complex IBA --
genes like me logo Genes that share ontologies with TRAPPC10: view

Pathways for TRAPPC10 Gene

SuperPathways for TRAPPC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport TAS 7633421
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport --
GO:0034498 early endosome to Golgi transport IBA --
GO:0035725 sodium ion transmembrane transport TAS 7633421
genes like me logo Genes that share ontologies with TRAPPC10: view

No data available for Pathways by source for TRAPPC10 Gene

Compounds for TRAPPC10 Gene

(2) Novoseek inferred chemical compound relationships for TRAPPC10 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
tyrosine 0 1
genes like me logo Genes that share compounds with TRAPPC10: view

Transcripts for TRAPPC10 Gene

Unigene Clusters for TRAPPC10 Gene

Trafficking protein particle complex 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAPPC10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^
SP1: - - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

ExUns: 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TRAPPC10 Gene

GeneLoc Exon Structure for
TRAPPC10
ECgene alternative splicing isoforms for
TRAPPC10

Expression for TRAPPC10 Gene

mRNA expression in normal human tissues for TRAPPC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC10 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC10 Gene Hs.126221

mRNA Expression by UniProt/SwissProt for TRAPPC10 Gene

P48553-TPC10_HUMAN
Tissue specificity: Expressed in all tissues examined
genes like me logo Genes that share expressions with TRAPPC10: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRAPPC10 Gene

Orthologs for TRAPPC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC10 35
  • 99.52 (n)
  • 99.76 (a)
TRAPPC10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC10 35
  • 86.18 (n)
  • 90.31 (a)
TRAPPC10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC10 35
  • 87.66 (n)
  • 91.18 (a)
TRAPPC10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc10 35
  • 84.95 (n)
  • 89.9 (a)
Trappc10 16
Trappc10 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC10 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC10 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc10 35
  • 84.38 (n)
  • 89.36 (a)
chicken
(Gallus gallus)
Aves TRAPPC10 35
  • 76.82 (n)
  • 83.45 (a)
TRAPPC10 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAPPC10 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc10 35
  • 66.91 (n)
  • 68.56 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc10 35
  • 63.85 (n)
  • 62.64 (a)
TRAPPC10 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002242 35
  • 47.37 (n)
  • 34.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta SIDL 35
  • 45.17 (n)
  • 33.06 (a)
SIDL 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trpp-10 36
  • 18 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS130 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for TRAPPC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC10 Gene

ENSEMBL:
Gene Tree for TRAPPC10 (if available)
TreeFam:
Gene Tree for TRAPPC10 (if available)

Paralogs for TRAPPC10 Gene

No data available for Paralogs for TRAPPC10 Gene

Variants for TRAPPC10 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC10 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs729882 -- 44,037,419(+) TAAAA(C/G)TGCAC intron-variant
rs915877 - 44,082,963(+) AGCAT(G/T)GAGAA missense, reference
rs915878 -- 44,083,913(+) AGCAT(C/T)AGTTA intron-variant
rs965733 -- 44,016,117(+) AATGA(C/G)CGAAT intron-variant
rs1051966 -- 44,012,457(+) CCCAT(C/G)GGGCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC10 Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913887 CNV Loss 21882294
nsv913890 CNV Loss 21882294
dgv4764n71 CNV Loss 21882294
dgv4765n71 CNV Loss 21882294
esv25124 CNV Gain 19812545
esv2723627 CNV Deletion 23290073

Relevant External Links for TRAPPC10 Gene

HapMap Linkage Disequilibrium report
TRAPPC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC10 Gene

Disorders for TRAPPC10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAPPC10 Gene including...

Search for TRAPPC10 Gene in MalaCards »

(5) Novoseek inferred disease relationships for TRAPPC10 Gene

Disease -log(P) Hits PubMed IDs
apeced 64.5 1
alzheimers disease 18.9 1
genetic disorder 15.7 1
immunodeficiency 8 5
tumors 0 1

Relevant External Links for TRAPPC10

GeneTests
TRAPPC10
GeneReviews
TRAPPC10
Genetic Association Database (GAD)
TRAPPC10
Human Genome Epidemiology (HuGE) Navigator
TRAPPC10
genes like me logo Genes that share disorders with TRAPPC10: view

No data available for UniProtKB/Swiss-Prot for TRAPPC10 Gene

Publications for TRAPPC10 Gene

  1. Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (PMID: 7633421) Yamakawa K. … Korenberg J.R. (Hum. Mol. Genet. 1995) 2 3 4 23
  2. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. (PMID: 9196060) Nagamine K. … Shimizu N. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. (PMID: 9370297) Lafreniere R.G. … Rouleau G.A. (Gene 1997) 3 4 23
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4

Products for TRAPPC10 Gene

Sources for TRAPPC10 Gene

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