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Aliases for TRAPPC1 Gene

Aliases for TRAPPC1 Gene

  • Trafficking Protein Particle Complex 1 2 3
  • BET5 3 4 6
  • MUM2 3 4 6
  • Multiple Myeloma Protein 2 3 4
  • BET5 Homolog 3 4
  • MUM-2 3 4
  • Trafficking Protein Particle Complex Subunit 1 3
  • Melanoma Ubiquitous Mutated 2 3

External Ids for TRAPPC1 Gene

Summaries for TRAPPC1 Gene

Entrez Gene Summary for TRAPPC1 Gene

  • This gene product plays a role in vesicular transport of proteins to the Golgi apparatus from the endoplasmic reticulum. The encoded protein is a component of the multisubunit transport protein particle (TRAPP) complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

GeneCards Summary for TRAPPC1 Gene

TRAPPC1 (Trafficking Protein Particle Complex 1) is a Protein Coding gene. Diseases associated with TRAPPC1 include multiple myeloma and myeloma.

UniProtKB/Swiss-Prot for TRAPPC1 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC1 Gene

Genomics for TRAPPC1 Gene

Genomic Location for TRAPPC1 Gene

Start:
7,930,345 bp from pter
End:
7,932,123 bp from pter
Size:
1,779 bases
Orientation:
Minus strand

Genomic View for TRAPPC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAPPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC1 Gene

Regulatory Elements for TRAPPC1 Gene

Proteins for TRAPPC1 Gene

  • Protein details for TRAPPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5R8-TPPC1_HUMAN
    Recommended name:
    Trafficking protein particle complex subunit 1
    Protein Accession:
    Q9Y5R8
    Secondary Accessions:
    • D3DTR0

    Protein attributes for TRAPPC1 Gene

    Size:
    145 amino acids
    Molecular mass:
    16832 Da
    Quaternary structure:
    • Part of the multisubunit TRAPP (transport protein particle) complex.

neXtProt entry for TRAPPC1 Gene

Proteomics data for TRAPPC1 Gene at MOPED

Post-translational modifications for TRAPPC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58 and Lys70

Other Protein References for TRAPPC1 Gene

No data available for DME Specific Peptides for TRAPPC1 Gene

Domains for TRAPPC1 Gene

Gene Families for TRAPPC1 Gene

HGNC:
  • TRAPPC :Trafficking protein particle complex

Protein Domains for TRAPPC1 Gene

UniProtKB/Swiss-Prot:

TPPC1_HUMAN
Family:
  • Belongs to the TRAPP small subunits family. BET5 subfamily.:
    • Q9Y5R8
genes like me logo Genes that share domains with TRAPPC1: view

Function for TRAPPC1 Gene

Molecular function for TRAPPC1 Gene

UniProtKB/Swiss-Prot Function: May play a role in vesicular transport from endoplasmic reticulum to Golgi

Gene Ontology (GO) - Molecular Function for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0017112 Rab guanyl-nucleotide exchange factor activity IBA --
genes like me logo Genes that share ontologies with TRAPPC1: view

Phenotypes for TRAPPC1 Gene

genes like me logo Genes that share phenotypes with TRAPPC1: view

miRNA for TRAPPC1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAPPC1 Gene

Localization for TRAPPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC1 Gene

Golgi apparatus, cis-Golgi network. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAPPC1 Gene COMPARTMENTS Subcellular localization image for TRAPPC1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IEA --
GO:0030008 TRAPP complex IBA --
genes like me logo Genes that share ontologies with TRAPPC1: view

Pathways for TRAPPC1 Gene

SuperPathways for TRAPPC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAPPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with TRAPPC1: view

No data available for Pathways by source for TRAPPC1 Gene

Compounds for TRAPPC1 Gene

(1) Drugbank Compounds for TRAPPC1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
S-PALMITOYL-L-CYSTEINE
target
genes like me logo Genes that share compounds with TRAPPC1: view

Transcripts for TRAPPC1 Gene

Unigene Clusters for TRAPPC1 Gene

Trafficking protein particle complex 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TRAPPC1 Gene

GeneLoc Exon Structure for
TRAPPC1
ECgene alternative splicing isoforms for
TRAPPC1

Expression for TRAPPC1 Gene

mRNA expression in normal human tissues for TRAPPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAPPC1 Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAPPC1 Gene

SOURCE GeneReport for Unigene cluster for TRAPPC1 Gene Hs.24379

genes like me logo Genes that share expressions with TRAPPC1: view

Orthologs for TRAPPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRAPPC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAPPC1 36
  • 99.77 (n)
  • 100 (a)
TRAPPC1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAPPC1 36
  • 96.09 (n)
  • 100 (a)
TRAPPC1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAPPC1 36
  • 94.48 (n)
  • 100 (a)
TRAPPC1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trappc1 36
  • 91.26 (n)
  • 98.62 (a)
Trappc1 16
Trappc1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAPPC1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAPPC1 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trappc1 36
  • 90.8 (n)
  • 98.62 (a)
lizard
(Anolis carolinensis)
Reptilia TRAPPC1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2590 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10881 36
trappc1 36
  • 74.25 (n)
  • 75.17 (a)
zebrafish
(Danio rerio)
Actinopterygii trappc1 36
  • 71.49 (n)
  • 77.93 (a)
trappc1 37
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000995 36
  • 58.04 (n)
  • 51.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bet5 36
  • 56.41 (n)
  • 54.55 (a)
Bet5 37
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_DC2.8 36
  • 52.8 (n)
  • 46.02 (a)
trpp-1 37
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BET5 37
  • 29 (a)
OneToOne
BET5 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51160 36
  • 53.48 (n)
  • 48.51 (a)
rice
(Oryza sativa)
Liliopsida Os01g0513700 36
  • 54.62 (n)
  • 50 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06176 36
  • 50.91 (n)
  • 42.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes bet5 36
  • 48.91 (n)
  • 39.42 (a)
Species with no ortholog for TRAPPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC1 Gene

ENSEMBL:
Gene Tree for TRAPPC1 (if available)
TreeFam:
Gene Tree for TRAPPC1 (if available)

Paralogs for TRAPPC1 Gene

Pseudogenes.org Pseudogenes for TRAPPC1 Gene

genes like me logo Genes that share paralogs with TRAPPC1: view

No data available for Paralogs for TRAPPC1 Gene

Variants for TRAPPC1 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_013028 A melanoma

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC1 Gene

Variant ID Type Subtype PubMed ID
nsv457660 CNV Loss 19166990
esv2670156 CNV Deletion 23128226

Relevant External Links for TRAPPC1 Gene

HapMap Linkage Disequilibrium report
TRAPPC1

Disorders for TRAPPC1 Gene

(2) MalaCards Diseases for TRAPPC1 Gene

Search for TRAPPC1 Gene in MalaCards »

Relevant External Links for TRAPPC1

Genetic Association Database (GAD)
TRAPPC1
Human Genome Epidemiology (HuGE) Navigator
TRAPPC1
genes like me logo Genes that share disorders with TRAPPC1: view

No data available for UniProtKB/Swiss-Prot for TRAPPC1 Gene

Publications for TRAPPC1 Gene

  1. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. (PMID: 10582700) Chiari R. … Coulie P.G. (Cancer Res. 1999) 2 3 4 23
  2. Functional organization of the yeast proteome by systematic analysis of protein complexes. (PMID: 11805826) Gavin A.-C. … Superti-Furga G. (Nature 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Multi-component protein complexes and Golgi membrane trafficking. (PMID: 15749823) Oka T. … Krieger M. (J. Biochem. 2005) 3
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3

Products for TRAPPC1 Gene

Sources for TRAPPC1 Gene

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