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TRAP1 Gene

protein-coding   GIFtS: 61
GCID: GC16M003710

TNF Receptor-Associated Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNF Receptor-Associated Protein 11 2     HSP 752 3
HSP752 3 5     TNFR-Associated Protein 12 3
Tumor Necrosis Factor Type 1 Receptor-Associated Protein2 3     HSP90L2 5
TRAP-12 3     Heat Shock Protein 75 KDa, Mitochondrial2

External Ids:    HGNC: 162641   Entrez Gene: 101312   Ensembl: ENSG000001266027   OMIM: 6062195   UniProtKB: Q129313   

Export aliases for TRAP1 gene to outside databases

Previous GC identifers: GC15U990048 GC16M003648 GC16M003709 GC16M003677


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAP1 Gene:
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family.
The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may
function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2013)

GeneCards Summary for TRAP1 Gene:
TRAP1 (TNF receptor-associated protein 1) is a protein-coding gene. Diseases associated with TRAP1 include hereditary multiple exostoses, and lupus nephritis. GO annotations related to this gene include tumor necrosis factor receptor binding and unfolded protein binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
Function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and
polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of
mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis.
The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and
inhibition of SDHA

Gene Wiki entry for TRAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAP1 gene promoter:
         NRSF form 1   MyoD   CUTL1   NRSF form 2   MEF-2A   CREB   deltaCREB   c-Myb   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003710:  view genomic region     (about GC identifiers)

Start:
3,701,640 bp from pter      End:
3,767,598 bp from pter
Size:
65,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931 (See protein sequence)
Recommended Name: Heat shock protein 75 kDa, mitochondrial precursor  
Size: 704 amino acids; 80110 Da
Subunit: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with
SRC. Interacts with SDHA
Sequence caution: Sequence=AAA87704.1; Type=Frameshift; Positions=656;
Secondary accessions: D3DUC8 O43642 O75235 Q9UHL5

Explore the universe of human proteins at neXtProt for TRAP1: NX_Q12931

Explore proteomics data for TRAP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys109, Lys699
  • Modification sites at PhosphoSitePlus

  • See TRAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258978.1  NP_057376.2  

    ENSEMBL proteins: 
     ENSP00000459385   ENSP00000246957   ENSP00000458166   ENSP00000442070   ENSP00000459354  
     ENSP00000459585   ENSP00000461618   ENSP00000458244   ENSP00000460545   ENSP00000461354  

    TRAP1 Human Recombinant Protein Products:

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    Novus Biologicals TRAP1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    4 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR003594 HATPase_ATP-bd
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q12931

    ProtoNet protein and cluster: Q12931

    1 Blocks protein domain: IPB001404 Heat shock protein Hsp90

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Similarity: Belongs to the heat shock protein 90 family


    TRAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAP1_HUMAN, Q12931
    Function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and
    polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of
    mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis.
    The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and
    inhibition of SDHA

         Genatlas biochemistry entry for TRAP1:
    tumor rejection antigen (gp96),pseudogene 1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005164tumor necrosis factor receptor binding NAS7876093
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    TRAP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRAP1:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAP1
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    miRNA
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    miRTarBase miRNAs that target TRAP1:
    hsa-mir-149-5p (MIRT045658), hsa-mir-17-5p (MIRT050940), hsa-mir-769-3p (MIRT039132), hsa-mir-193b-3p (MIRT041401), hsa-mir-361-3p (MIRT038265), hsa-mir-197-3p (MIRT048118), hsa-mir-222-3p (MIRT046825), hsa-mir-186-5p (MIRT045192), hsa-mir-331-3p (MIRT043532), hsa-mir-196a-5p (MIRT048268), hsa-mir-1180-3p (MIRT035913), hsa-mir-16-5p (MIRT031812), hsa-mir-92a-3p (MIRT049372), hsa-mir-342-3p (MIRT043734), hsa-mir-26a-5p (MIRT050189), hsa-mir-324-5p (MIRT043185), hsa-mir-25-3p (MIRT050345), hsa-mir-615-3p (MIRT040106), hsa-mir-424-5p (MIRT042452)

    Block miRNA regulation of human, mouse, rat TRAP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TRAP1:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRAP1_HUMAN, Q12931: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005759mitochondrial matrix IDA--

    TRAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Immune response Antigen presentation by MHC class I0.68
    2Development IGF 1 receptor signaling
    Signal transduction AKT signaling0.49
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    4TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    5Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for TRAP1
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling

    1 BioSystems Pathway for TRAP1
        TGF-beta Receptor Signaling Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including TRAP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAP1 (Q129312, 3 ENSP000002469574) via UniProtKB, MINT, STRING, and/or I2D (see all 946)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PEX14O753812, 3, ENSP000003490164MINT-7231379 I2D: score=1 STRING: ENSP00000349016
    SF3A2Q154282, 3, ENSP000002214944MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006950response to stress IEA--
    GO:1901856negative regulation of cellular respiration IMP--

    TRAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAP1

    2 Novoseek inferred chemical compound relationships for TRAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 28.5 9 16927372 (2), 15292218 (1), 17513296 (1), 18091755 (1) (see all 5)
    atp 22.7 3 18091755 (2), 10652318 (1)



    TRAP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAP1 gene (2 alternative transcripts): 
    NM_001272049.1  NM_016292.2  

    Unigene Cluster for TRAP1:

    TNF receptor-associated protein 1
    Hs.30345  [show with all ESTs]
    Unigene Representative Sequence: NM_016292
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575707 ENST00000246957(uc002cvt.4 uc010uxf.2) ENST00000574494
    ENST00000575671(uc002cvs.3) ENST00000538171 ENST00000573872 ENST00000576335
    ENST00000574175 ENST00000570514 ENST00000575854 ENST00000576788 ENST00000571804
    ENST00000574941 ENST00000576106 ENST00000571538 ENST00000571011 ENST00000570403

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      QuantiTect SYBR Green Assays in human, mouse, rat TRAP1
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    Additional mRNA sequence: 

    AB209805.1 AF043254.1 AF154108.1 AJ890085.1 AK057620.1 AK093344.1 AK098732.1 AK223049.1 
    AK223076.1 AK223205.1 AK299127.1 BC000406.2 BC001455.2 BC002994.1 BC018950.2 BC023585.2 
    JX481354.1 U12595.1 

    Selected DOTS entries (see all 35):

    DT.97855786  DT.100827945  DT.99967729  DT.454812  DT.91905331  DT.100827937  DT.448353  DT.100827944 
    DT.100039414  DT.100827956  DT.100039421  DT.40243143  DT.120677547  DT.95286913  DT.100644020  DT.100827941 
    DT.100827949  DT.120677491  DT.92471386  DT.100642972  DT.120677523  DT.120677526  DT.120677548  DT.120677601 

    Selected AceView cDNA sequences (see all 788):

    NM_016292 CR612283 BQ690341 CA489677 BQ681919 CF551891 BE727784 CR623319 
    F05180 CB127149 BG259863 BM991593 BM912389 CK821412 BU630567 BI964201 
    BE391789 BQ420885 BC001455 BU170277 AI684293 BM977355 BU162124 BQ958827 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAP1 expression in normal human tissues (normalized intensities)      TRAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGCCGCT
    TRAP1 Expression
    About this image


    TRAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TRAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30345

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder.
    Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but
    it is increased in other type of tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including TRAP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for TRAP1
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    QuantiFast Probe-based Assays in human, mouse, rat TRAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRAP1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trap11 , 5 TNF receptor-associated protein 11, 5 84.37(n)1
    88.49(a)1
      16 (2.38 cM)5
    680151  NM_026508.21  NP_080784.11 
     40399715 
    chicken
    (Gallus gallus)
    Aves TRAP11 TNF receptor-associated protein 1 78.44(n)
    83.58(a)
      416666  NM_001006175.1  NP_001006175.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAP16
    TNF receptor-associated protein 1
    73(a)
    1 ↔ 1
    GL343507.1(520668-529369)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.91482 Xenopus laevis transcribed sequence with moderate similarity more 78.98(n)    CF285902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc85a112 Transcribed sequence with moderate similarity to protein more 79.97(n)    BI709020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trap11 , 3 chaperone3
    Trap11
    52(a)3
    57.6(n)1
    54.4(a)1
      42C13
    355591  NM_001273797.11  NP_001260726.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.7b3
    R151.71
    R151.71 48(a)
    (best of 2)3
    52.37(n)1
    47.52(a)1
      III(7295099-7298408)3
    1760191  NM_171881.51  NP_741220.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC826
    Cytoplasmic chaperone of the Hsp90 family, redunda...
    29(a)
    1 → many
    XIII(632355-634472) YMR186W


    ENSEMBL Gene Tree for TRAP1 (if available)
    TreeFam Gene Tree for TRAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAP1 gene
    HSP90B12  
    6 SIMAP similar genes for TRAP1 using alignment to 12 protein entries:     TRAP1_HUMAN (see all proteins):
    HSP90AA2    HSP90B1    HSP90AA1    HSP90AB1    EL52    TRA1

    TRAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAP1 (see all 1929)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735054601,2
    C,F--3643564(+) TAGTTT/GAGTTC 2 -- ds50013Minor allele frequency- G:0.11WA 122
    rs1394382351,2
    --3643578(+) CGGGTA/GCTGAG 2 -- ds50010--------
    rs1912268531,2
    --3643585(+) TGAGCC/TAGGCC 2 -- ds50010--------
    rs788692031,2
    C,F--3643587(+) AGCCAG/AGCCCA 2 -- ds50011Minor allele frequency- A:0.08WA 118
    rs2009503961,2
    --3643596(+) CATGTA/GTGAAA 2 -- ds50010--------
    rs2017550371,2
    --3643603(+) GAAAGC/GGGAAC 2 -- ds50010--------
    rs2007081511,2
    --3643618(+) TTTCTC/GTTCCC 2 -- ds50010--------
    rs2015174071,2
    C--3643639(+) AGGATC/TGTGGT 2 -- ds50011Minor allele frequency- T:0.00EU 1323
    rs2001499841,2
    --3643643(+) TCGTGC/GTTGCA 2 -- ds50010--------
    rs2015714121,2
    C--3643661(+) TGCTCC/TGAGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRAP1 (3701640 - 3767598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRAP1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666403CNV Deletion23128226
    esv2659167CNV Deletion23128226
    nsv1717CNV Insertion18451855
    nsv905213CNV Loss21882294
    nsv525301CNV Loss19592680
    nsv457359CNV Loss19166990
    nsv905216CNV Loss21882294
    nsv833129CNV Loss17160897
    nsv833128CNV Loss17160897
    nsv516876CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606219    OMIM disorders: --

    18 diseases for TRAP1:    About MalaCards
    hereditary multiple exostoses    lupus nephritis    nephritis    down syndrome
    retinoblastoma    cerebritis    tonsillitis    hepatitis b
    tuberculosis    ovarian cancer    hepatocellular carcinoma    prostatitis
    prostate cancer    leukemia    thyroiditis    hepatitis
    malaria    endotheliitis


    TRAP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for TRAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.4 15 17513296 (2), 17579517 (1), 7876093 (1), 14596856 (1) (see all 5)
    necrosis 27.8 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)
    leukemia 13.8 2 15292218 (1), 14596856 (1)
    tumors 4.24 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)

    Genetic Association Database (GAD): TRAP1
    Human Genome Epidemiology (HuGE) Navigator: TRAP1 (8 documents)

    Export disorders for TRAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAP1 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with TRAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PubMed id 10652318)1, 2, 3, 9 Felts S.J.... Toft D.O. (J. Biol. Chem. 2000)
    2. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PubMed id 7876093)1, 2, 3, 9 Song H.Y.... Donner D.B. (J. Biol. Chem. 1995)
    3. TRAP1 rescues PINK1 loss-of-function phenotypes. (PubMed id 23525905)1, 2 Zhang L....Voigt A. (Hum. Mol. Genet. 2013)
    4. The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. (PubMed id 23747254)1, 2 Sciacovelli M.... Rasola A. (Cell Metab. 2013)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. (PubMed id 10545594)1, 2 Simmons A.D....Lovett M. (Hum. Mol. Genet. 1999)
    9. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. (PubMed id 8756626)1, 2 Chen C.-F.... Lee W.-H. (Mol. Cell. Biol. 1996)
    10. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)1, 9 Pridgeon J.W....Li L. (PLoS Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10131 HGNC: 16264 AceView: TRAP1 Ensembl:ENSG00000126602 euGenes: HUgn10131
    ECgene: TRAP1 H-InvDB: TRAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRAP1 gene:
    Search GeneIP for patents involving TRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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