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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAP1 Gene

protein-coding   GIFtS: 60
GCID: GC16M003710

TNF Receptor-Associated Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNF Receptor-Associated Protein 11 2     HSP 752 3
HSP752 3 5     TNFR-Associated Protein 12 3
Tumor Necrosis Factor Type 1 Receptor-Associated Protein2 3     HSP90L2 5
TRAP-12 3     Heat Shock Protein 75 KDa, Mitochondrial2

External Ids:    HGNC: 162641   Entrez Gene: 101312   Ensembl: ENSG000001266027   OMIM: 6062195   UniProtKB: Q129313   

Export aliases for TRAP1 gene to outside databases

Previous GC identifers: GC15U990048 GC16M003648 GC16M003709 GC16M003677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAP1 Gene:
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family.
The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may
function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Jan 2013)

GeneCards Summary for TRAP1 Gene: 
TRAP1 (TNF receptor-associated protein 1) is a protein-coding gene. Diseases associated with TRAP1 include hereditary multiple exostoses, and down syndrome, and among its related super-pathways are Immune response Antigen presentation by MHC class I and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include tumor necrosis factor receptor binding and unfolded protein binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
Function: Chaperone that expresses an ATPase activity

Gene Wiki entry for TRAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAP1 gene promoter:
         NRSF form 1   MyoD   CUTL1   NRSF form 2   MEF-2A   CREB   deltaCREB   c-Myb   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003710:  view genomic region     (about GC identifiers)

Start:
3,701,640 bp from pter      End:
3,767,598 bp from pter
Size:
65,959 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931 (See protein sequence)
Recommended Name: Heat shock protein 75 kDa, mitochondrial precursor  
Size: 704 amino acids; 80110 Da
Subunit: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAA87704.1; Type=Frameshift; Positions=656;
Secondary accessions: D3DUC8 O43642 O75235 Q9UHL5

Explore the universe of human proteins at neXtProt for TRAP1: NX_Q12931

Explore proteomics data for TRAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12931

  • TRAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258978.1  NP_057376.2  

    ENSEMBL proteins: 
     ENSP00000459385   ENSP00000246957   ENSP00000458166   ENSP00000442070   ENSP00000459354  
     ENSP00000459585   ENSP00000461618   ENSP00000458244   ENSP00000460545   ENSP00000461354  

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    Novus Biologicals TRAP1 Proteins
    Novus Biologicals TRAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IDA--
    GO:0005759mitochondrial matrix IDA--

    TRAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSPC: Heat shock proteins / HSPC

    4 InterPro protein domains:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR003594 HATPase_ATP-bd
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q12931

    ProtoNet protein and cluster: Q12931

    1 Blocks protein domain: IPB001404 Heat shock protein Hsp90

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Similarity: Belongs to the heat shock protein 90 family


    TRAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAP1_HUMAN, Q12931
    Function: Chaperone that expresses an ATPase activity

         Genatlas biochemistry entry for TRAP1:
    tumor rejection antigen (gp96),pseudogene 1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005164tumor necrosis factor receptor binding NAS7876093
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    TRAP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRAP1:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAP1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRAP1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class I
    Immune response Antigen presentation by MHC class I0.92
    2Development VEGF signaling via VEGFR2 - generic cascades
    Development VEGF signaling via VEGFR2 - generic cascades0.51
    3Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling1.00
    4Development IGF-RI signaling
    Signal transduction AKT signaling0.49
    5CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for TRAP1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Signal transduction AKT signaling


    5 GeneGo (Thomson Reuters) Pathways for TRAP1
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling

    1 BioSystems Pathway for TRAP1
        TGF-beta Receptor Signaling Pathway



    TRAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/868 Interacting proteins for TRAP1 (Q129312, 3 ENSP000002469574) via UniProtKB, MINT, STRING, and/or I2D (see all 868)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PEX14O753812, 3, ENSP000003490164MINT-7231379 I2D: score=1 STRING: ENSP00000349016
    SF3A2Q154282, 3, ENSP000002214944MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006950response to stress IEA--
    GO:1901856negative regulation of cellular respiration IMP--

    TRAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAP1

    2 Novoseek inferred chemical compound relationships for TRAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 28.5 9 16927372 (2), 15292218 (1), 17513296 (1), 18091755 (1) (see all 5)
    atp 22.7 3 18091755 (2), 10652318 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAP1 gene (2 alternative transcripts): 
    NM_001272049.1  NM_016292.2  

    Unigene Cluster for TRAP1:

    TNF receptor-associated protein 1
    Hs.30345  [show with all ESTs]
    Unigene Representative Sequence: NM_016292
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575707 ENST00000246957(uc002cvt.4 uc010uxf.2) ENST00000574494
    ENST00000575671(uc002cvs.3) ENST00000538171 ENST00000573872 ENST00000576335
    ENST00000574175 ENST00000570514 ENST00000575854 ENST00000576788 ENST00000571804
    ENST00000574941 ENST00000576106 ENST00000571538 ENST00000571011 ENST00000570403

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRAP1:
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    Additional mRNA sequence: 

    AB209805.1 AF043254.1 AF154108.1 AJ890085.1 AK057620.1 AK093344.1 AK098732.1 AK223049.1 
    AK223076.1 AK223205.1 AK299127.1 BC000406.2 BC001455.2 BC002994.1 BC018950.2 BC023585.2 
    JX481354.1 U12595.1 

    24/35 DOTS entries (see all 35):

    DT.97855786  DT.100827945  DT.99967729  DT.454812  DT.91905331  DT.100827937  DT.448353  DT.100827944 
    DT.100039414  DT.100827956  DT.100039421  DT.40243143  DT.120677547  DT.95286913  DT.100644020  DT.100827941 
    DT.100827949  DT.120677491  DT.92471386  DT.100642972  DT.120677523  DT.120677526  DT.120677548  DT.120677601 

    24/788 AceView cDNA sequences (see all 788):

    BQ636525 BM670495 BM904828 BQ073551 BM977355 CK821412 AW250387 BM013683 
    BM904670 C04875 BM820589 BQ233677 AI866925 BQ230027 BU631308 BI819500 
    BM797853 AI684293 CF551891 BI791584 BM551215 BM848669 BM826185 BX425318 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAP1 expression in normal human tissues (normalized intensities)      TRAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGCCGCT
    TRAP1 Expression
    About this image


    TRAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TRAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAP1

    SOURCE GeneReport for Unigene cluster: Hs.30345

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including TRAP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRAP1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trap11 , 5 TNF receptor-associated protein 11, 5 84.33(n)1
    88.49(a)1
      16 (2.38 cM)5
    680151  NM_026508.21  NP_080784.11 
     40399715 
    chicken
    (Gallus gallus)
    Aves TRAP11 TNF receptor-associated protein 1 78.39(n)
    83.58(a)
      416666  NM_001006175.1  NP_001006175.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAP16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    GL343507.1(520668-529369)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.91482 Xenopus laevis transcribed sequence with moderate similarity more 78.98(n)    CF285902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc85a112 Transcribed sequence with moderate similarity to protein more 79.97(n)    BI709020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trap11 , 3 chaperone3
    CG3152-PA1
    52(a)3
    57.71(n)1
    54.4(a)1
      42C13
    355591  NM_058091.31  NP_477439.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.7b3
    R151.71
    Protein R151.71 48(a)
    (best of 2)3
    52.43(n)1
    47.52(a)1
      III(7295099-7298408)3
    1760191  NM_171881.41  NP_741220.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSP826
    HSC826
    Hsp90 chaperone required for pheromone signaling a...
    Cytoplasmic chaperone of the Hsp90 family, redunda...
    29(a)
    28(a)
    many ↔ many
    many ↔ many
    XVI(96496-98625)
    XIII(632355-634472)


    ENSEMBL Gene Tree for TRAP1 (if available)
    TreeFam Gene Tree for TRAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAP1 gene
    HSP90B12  HSP90AB12  HSP90AA12  
    6 SIMAP similar genes for TRAP1 using alignment to 12 protein entries:     TRAP1_HUMAN (see all proteins):
    HSP90AA2    HSP90B1    HSP90AA1    HSP90AB1    EL52    TRA1

    TRAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1929 SNPs in TRAP1 are shown (see all 1929)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735054601,2
    C,F--3643564(+) TAGTTT/GAGTTC 2 -- ds50013Minor allele frequency- G:0.11WA 122
    rs1394382351,2
    --3643578(+) CGGGTA/GCTGAG 2 -- ds50010--------
    rs1912268531,2
    --3643585(+) TGAGCC/TAGGCC 2 -- ds50010--------
    rs788692031,2
    C,F--3643587(+) AGCCAG/AGCCCA 2 -- ds50011Minor allele frequency- A:0.08WA 118
    rs2009503961,2
    --3643596(+) CATGTA/GTGAAA 2 -- ds50010--------
    rs2017550371,2
    --3643603(+) GAAAGC/GGGAAC 2 -- ds50010--------
    rs2007081511,2
    --3643618(+) TTTCTC/GTTCCC 2 -- ds50010--------
    rs2015174071,2
    C--3643639(+) AGGATC/TGTGGT 2 -- ds50011Minor allele frequency- T:0.00EU 1323
    rs2001499841,2
    --3643643(+) TCGTGC/GTTGCA 2 -- ds50010--------
    rs2015714121,2
    C--3643661(+) TGCTCC/TGAGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRAP1 (3701640 - 3767598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TRAP1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666403CNV Deletion23128226
    esv2659167CNV Deletion23128226
    nsv1717CNV Insertion18451855
    nsv905213CNV Loss21882294
    nsv525301CNV Loss19592680
    nsv457359CNV Loss19166990
    nsv905216CNV Loss21882294
    nsv833129CNV Loss17160897
    nsv833128CNV Loss17160897
    nsv516876CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606219    OMIM disorders: --

    8 diseases for TRAP1:    About MalaCards
    hereditary multiple exostoses    down syndrome    retinoblastoma    cerebritis
    tuberculosis    hepatocellular carcinoma    prostate cancer    prostatitis


    TRAP1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for TRAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.4 15 17513296 (2), 17579517 (1), 7876093 (1), 14596856 (1) (see all 5)
    necrosis 27.8 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)
    leukemia 13.8 2 15292218 (1), 14596856 (1)
    tumors 4.24 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)

    Genetic Association Database (GAD): TRAP1
    Human Genome Epidemiology (HuGE) Navigator: TRAP1 (8 documents)

    Export disorders for TRAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAP1 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with TRAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PubMed id 10652318)1, 2, 3, 9 Felts S.J.... Toft D.O. (2000)
    2. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PubMed id 7876093)1, 2, 3, 9 Song H.Y.... Donner D.B. (1995)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. (PubMed id 10545594)1, 2 Simmons A.D....Lovett M. (1999)
    7. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. (PubMed id 8756626)1, 2 Chen C.-F.... Lee W.-H. (1996)
    8. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)1, 9 Pridgeon J.W....Li L. (2007)
    9. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. (PubMed id 15292218)1, 9 Masuda Y....Nakaya K. (2004)
    10. Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. (PubMed id 16927372)1, 9 Im C.N....Seo J.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10131 HGNC: 16264 AceView: TRAP1 Ensembl:ENSG00000126602 euGenes: HUgn10131
    ECgene: TRAP1 H-InvDB: TRAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAP1 gene:
    Search GeneIP for patents involving TRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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