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Aliases for TRAP1 Gene

Aliases for TRAP1 Gene

  • TNF Receptor-Associated Protein 1 2 3
  • HSP75 3 4 6
  • Tumor Necrosis Factor Type 1 Receptor-Associated Protein 3 4
  • TNFR-Associated Protein 1 3 4
  • HSP 75 3 4
  • HSP90L 3 6
  • TRAP-1 3 4
  • Heat Shock Protein 75 KDa, Mitochondrial 3

External Ids for TRAP1 Gene

Previous GeneCards Identifiers for TRAP1 Gene

  • GC15U990048
  • GC16M003648
  • GC16M003709
  • GC16M003677
  • GC16M003710

Summaries for TRAP1 Gene

Entrez Gene Summary for TRAP1 Gene

  • This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRAP1 Gene

TRAP1 (TNF Receptor-Associated Protein 1) is a Protein Coding gene. Diseases associated with TRAP1 include hereditary multiple exostoses. Among its related pathways are TGF-beta Receptor Signaling Pathway and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include unfolded protein binding and tumor necrosis factor receptor binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot for TRAP1 Gene

  • Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene Wiki entry for TRAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAP1 Gene

Genomics for TRAP1 Gene

Regulatory Elements for TRAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAP1 Gene

Start:
3,651,639 bp from pter
End:
3,717,597 bp from pter
Size:
65,959 bases
Orientation:
Minus strand

Genomic View for TRAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAP1 Gene

Proteins for TRAP1 Gene

  • Protein details for TRAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12931-TRAP1_HUMAN
    Recommended name:
    Heat shock protein 75 kDa, mitochondrial
    Protein Accession:
    Q12931
    Secondary Accessions:
    • B4DR68
    • D3DUC8
    • F5H897
    • O43642
    • O75235
    • Q9UHL5

    Protein attributes for TRAP1 Gene

    Size:
    704 amino acids
    Molecular mass:
    80110 Da
    Quaternary structure:
    • Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1. Interacts with SRC. Interacts with SDHA.
    SequenceCaution:
    • Sequence=AAA87704.1; Type=Frameshift; Positions=656; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAP1 Gene

Proteomics data for TRAP1 Gene at MOPED

Post-translational modifications for TRAP1 Gene

  • Ubiquitination at Lys109 and Lys699
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAP1 (HSP75)

No data available for DME Specific Peptides for TRAP1 Gene

Domains for TRAP1 Gene

Gene Families for TRAP1 Gene

HGNC:
  • HSPC :Heat shock proteins / HSPC

Protein Domains for TRAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q12931

UniProtKB/Swiss-Prot:

TRAP1_HUMAN :
  • Q12931
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with TRAP1: view

Function for TRAP1 Gene

Molecular function for TRAP1 Gene

GENATLAS Biochemistry: tumor rejection antigen (gp96),pseudogene 1
UniProtKB/Swiss-Prot Function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

Gene Ontology (GO) - Molecular Function for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005164 tumor necrosis factor receptor binding NAS 7876093
GO:0005515 protein binding IPI 23564345
GO:0005524 ATP binding IEA --
GO:0019901 protein kinase binding IPI 17579517
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRAP1: view

Phenotypes for TRAP1 Gene

genes like me logo Genes that share phenotypes with TRAP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAP1 Gene

Localization for TRAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAP1 Gene

Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAP1 Gene COMPARTMENTS Subcellular localization image for TRAP1 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IDA 23564345
GO:0005758 mitochondrial intermembrane space ISS 17579517
genes like me logo Genes that share ontologies with TRAP1: view

Pathways for TRAP1 Gene

genes like me logo Genes that share pathways with TRAP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding --
GO:0006950 response to stress IEA --
GO:0009386 translational attenuation IMP 24113185
GO:0061077 chaperone-mediated protein folding TAS 24522549
GO:1901856 negative regulation of cellular respiration IMP 23564345
genes like me logo Genes that share ontologies with TRAP1: view

Compounds for TRAP1 Gene

(2) Novoseek inferred chemical compound relationships for TRAP1 Gene

Compound -log(P) Hits PubMed IDs
oxygen 28.5 6
atp 22.7 3
genes like me logo Genes that share compounds with TRAP1: view

Transcripts for TRAP1 Gene

Unigene Clusters for TRAP1 Gene

TNF receptor-associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAP1 Gene

No ASD Table

Relevant External Links for TRAP1 Gene

GeneLoc Exon Structure for
TRAP1
ECgene alternative splicing isoforms for
TRAP1

Expression for TRAP1 Gene

mRNA expression in normal human tissues for TRAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAP1 Gene

SOURCE GeneReport for Unigene cluster for TRAP1 Gene Hs.30345

mRNA Expression by UniProt/SwissProt for TRAP1 Gene

Q12931-TRAP1_HUMAN
Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors.
genes like me logo Genes that share expressions with TRAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRAP1 Gene

Orthologs for TRAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAP1 35
  • 98.86 (n)
  • 99.15 (a)
TRAP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAP1 35
  • 86.57 (n)
  • 88 (a)
TRAP1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAP1 35
  • 87.81 (n)
  • 90 (a)
TRAP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trap1 35
  • 84.37 (n)
  • 88.49 (a)
Trap1 16
Trap1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAP1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trap1 35
  • 84.8 (n)
  • 88.49 (a)
chicken
(Gallus gallus)
Aves TRAP1 35
  • 78.44 (n)
  • 83.58 (a)
TRAP1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAP1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9148 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16680 35
trap1 35
  • 73.5 (n)
  • 80.97 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.291 35
zebrafish
(Danio rerio)
Actinopterygii LOC101884569 35
  • 74.85 (n)
  • 80.56 (a)
trap1 36
  • 67 (a)
OneToMany
trap1 36
  • 73 (a)
OneToMany
wufc85a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010691 35
  • 59.43 (n)
  • 56.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trap1 35
  • 57.6 (n)
  • 54.4 (a)
Trap1 36
  • 49 (a)
OneToOne
Trap1 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea R151.7 35
  • 52.37 (n)
  • 47.52 (a)
R151.7 36
  • 41 (a)
OneToOne
R151.7a 37
  • 46 (a)
R151.7b 37
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for TRAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAP1 Gene

ENSEMBL:
Gene Tree for TRAP1 (if available)
TreeFam:
Gene Tree for TRAP1 (if available)

Paralogs for TRAP1 Gene

Paralogs for TRAP1 Gene

genes like me logo Genes that share paralogs with TRAP1: view

Variants for TRAP1 Gene

Sequence variations from dbSNP and Humsavar for TRAP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs38024 -- 3,710,881(+) tatat(A/T)ttttt intron-variant
rs38025 -- 3,713,733(+) GAGAC(C/T)GCGTC intron-variant
rs38026 -- 3,719,585(+) aggag(A/G)tgaag upstream-variant-2KB
rs40536 -- 3,718,326(+) tagag(A/G)tcata upstream-variant-2KB
rs43223 -- 3,714,262(+) TTTGA(A/C)GACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAP1 Gene

Variant ID Type Subtype PubMed ID
nsv905213 CNV Loss 21882294
nsv833128 CNV Loss 17160897
nsv905216 CNV Loss 21882294
nsv518509 CNV Gain 19592680
esv2659167 CNV Deletion 23128226
nsv457359 CNV Loss 19166990
nsv525301 CNV Loss 19592680
nsv833129 CNV Loss 17160897
nsv516876 CNV Loss 19592680
nsv1717 CNV Insertion 18451855
esv2666403 CNV Deletion 23128226

Relevant External Links for TRAP1 Gene

HapMap Linkage Disequilibrium report
TRAP1
Human Gene Mutation Database (HGMD)
TRAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAP1 Gene

Disorders for TRAP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAP1 Gene including...

Search for TRAP1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for TRAP1 Gene

Disease -log(P) Hits PubMed IDs
shock 52.4 6
necrosis 27.8 7
leukemia 13.8 2
tumors 4.24 7

Relevant External Links for TRAP1

Genetic Association Database (GAD)
TRAP1
Human Genome Epidemiology (HuGE) Navigator
TRAP1
genes like me logo Genes that share disorders with TRAP1: view

No data available for UniProtKB/Swiss-Prot for TRAP1 Gene

Publications for TRAP1 Gene

  1. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PMID: 7876093) Song H.Y. … Donner D.B. (J. Biol. Chem. 1995) 2 3 4 23
  2. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PMID: 10652318) Felts S.J. … Toft D.O. (J. Biol. Chem. 2000) 2 3 4 23
  3. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. (PMID: 15292218) Masuda Y. … Nakaya K. (J. Biol. Chem. 2004) 3 23
  4. Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. (PMID: 16927372) Im C.N. … Seo J.S. (J. Cell. Biochem. 2007) 3 23
  5. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PMID: 17579517) Pridgeon J.W. … Li L. (PLoS Biol. 2007) 3 23

Products for TRAP1 Gene

Sources for TRAP1 Gene

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