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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAP1 Gene

protein-coding   GIFtS: 59
GCID: GC16M003710

TNF receptor-associated protein 1

 Explore 12 diseases affiliated with
TRAP1 via our new
 Human Malady Compendium 
Biological research products
for TRAP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TNF Receptor-Associated Protein 11 2     TRAP-12 3
HSP751 2 3 5     HSP 752 3
HSP90L1 2 5     TNFR-Associated Protein 12 3
Tumor Necrosis Factor Type 1 Receptor-Associated Protein2 3     Heat Shock Protein 75 KDa, Mitochondrial2

External Ids:    HGNC: 162641   Entrez Gene: 101312   Ensembl: ENSG000001266027   OMIM: 6062195   UniProtKB: Q129313   

Export aliases for TRAP1 gene to outside databases

Previous GC identifers: GC15U990048 GC16M003648 GC16M003709 GC16M003677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAP1:
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The
encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in
regulating cellular stress responses. Alternate splicing results in multiple transcript variants. (provided by RefSeq,
Jan 2013)

UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
Function: Chaperone that expresses an ATPase activity

Gene Wiki entry for TRAP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAP1 gene promoter:
         NRSF form 1   MyoD   CUTL1   NRSF form 2   MEF-2A   CREB   deltaCREB   c-Myb   aMEF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TRAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M003710:  view genomic region     (about GC identifiers)

Start:
3,701,640 bp from pter      End:
3,767,598 bp from pter
Size:
65,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931 (See protein sequence)
Recommended Name: Heat shock protein 75 kDa, mitochondrial precursor  
Size: 704 amino acids; 80110 Da
Subunit: Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAA87704.1; Type=Frameshift; Positions=656;
Secondary accessions: D3DUC8 O43642 O75235 Q9UHL5

Explore the universe of human proteins at neXtProt for TRAP1: NX_Q12931

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12931

  • TRAP1 Protein expression data from MOPED and PaxDb:    About this image 
    TRAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001258978.1  NP_057376.2  

    ENSEMBL proteins: 
     ENSP00000459385   ENSP00000246957   ENSP00000458166   ENSP00000442070   ENSP00000459354  
     ENSP00000459585   ENSP00000461618   ENSP00000458244   ENSP00000460545   ENSP00000461354  

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    Novus Biologicals TRAP1 Proteins
    Novus Biologicals TRAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRAP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    TRAP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRAP1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR003594 ATPase-like_ATP-bd
     IPR020568 Ribosomal_S5_D2-typ_fold

    Graphical View of Domain Structure for InterPro Entry Q12931

    ProtoNet protein and cluster: Q12931

    1 Blocks protein family: IPB001404 Heat shock protein Hsp90

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Similarity: Belongs to the heat shock protein 90 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAP1_HUMAN, Q12931
    Function: Chaperone that expresses an ATPase activity

         Genatlas biochemistry entry for TRAP1:
    tumor rejection antigen (gp96),pseudogene 1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005164tumor necrosis factor receptor binding NAS7876093
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    TRAP1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRAP1:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRAP1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRAP1:
    hsa-miR-9*
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    Development_Glucocorticoid receptor signaling0.27
    Development Glucocorticoid receptor signaling0.27
    2Immune response Antigen presentation by MHC class I
    Immune response Antigen presentation by MHC class I1.00
    Immune response_Antigen presentation by MHC class I0.92
    3Development IGF-RI signaling
    Signal transduction_AKT signaling0.49
    Signal transduction AKT signaling0.49
    4TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway1.00
    5Development VEGF signaling via VEGFR2 - generic cascades
    Development_VEGF signaling via VEGFR2 - generic cascades0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for TRAP1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Signal transduction AKT signaling


    5 GeneGo (Thomson Reuters) Pathways for TRAP1
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling

    1 BioSystems Pathway for TRAP1 
        TGF-beta Receptor Signaling Pathway



    TRAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/831 Interacting proteins for TRAP1 (Q129312, 3 ENSP000002469574) via UniProtKB, MINT, STRING, and/or I2D (see all 831)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PEX14O753812, 3, ENSP000003490164MINT-7231379 I2D: score=1 STRING: ENSP00000349016
    SF3A2Q154282, 3, ENSP000002214944MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006950response to stress ----
    GO:0034599cellular response to oxidative stress IDA16551573

    TRAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAP1
    2 Novoseek chemical compound relationships for TRAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxygen 28.5 9 16927372 (2), 15292218 (1), 17513296 (1), 18091755 (1) (see all 5)
    atp 22.7 3 18091755 (2), 10652318 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAP1 gene (2 alternative transcripts): 
    NM_001272049.1  NM_016292.2  

    Unigene Cluster for TRAP1:

    TNF receptor-associated protein 1
    Hs.30345  [show with all ESTs]
    Unigene Representative Sequence: NM_016292
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575707 ENST00000246957(uc002cvt.4 uc010uxf.2) ENST00000574494
    ENST00000575671(uc002cvs.3) ENST00000538171 ENST00000573872 ENST00000576335
    ENST00000574175 ENST00000570514 ENST00000575854 ENST00000576788 ENST00000571804
    ENST00000574941 ENST00000576106 ENST00000571538 ENST00000571011 ENST00000570403


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    hsa-miR-9*
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB209805.1 AF043254.1 AF154108.1 AJ890085.1 AK057620.1 AK093344.1 AK098732.1 AK223049.1 
    AK223076.1 AK223205.1 AK299127.1 BC000406.2 BC001455.2 BC002994.1 BC018950.2 BC023585.2 
    JX481354.1 U12595.1 

    24/35 DOTS entries (see all 35):

    DT.97855786  DT.100827945  DT.99967729  DT.454812  DT.91905331  DT.100827937  DT.448353  DT.100827944 
    DT.100039414  DT.100827956  DT.40243143  DT.120677547  DT.95286913  DT.100039421  DT.100644020  DT.100827941 
    DT.100827949  DT.120677491  DT.92471386  DT.100642972  DT.120677523  DT.120677526  DT.120677548  DT.120677601 

    24/788 AceView cDNA sequences (see all 788):

    AA442987 BC023585 AK057620 CB112240 BQ230027 BE615542 CD671242 F05180 
    BQ690341 BM839310 AW630882 BQ673544 BU558065 BM975814 AA581906 C05396 
    BQ681919 BQ447416 BE276348 BU190205 BQ959106 BU189909 BM762565 BU173169 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGGCCGCT
    TRAP1 Expression
    About this image
    See TRAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAP1

    SOURCE GeneReport for Unigene cluster: Hs.30345

    UniProtKB/Swiss-Prot: TRAP1_HUMAN, Q12931
    Tissue specificity: Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including TRAP1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAP1 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TRAP11 TNF receptor-associated protein 1 78.39(n)
    83.58(a)
      416666  NM_001006175.1  NP_001006175.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAP16
    --
    73(a)
    1 ↔ 1
    GL343507.1(520668-529369)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.91482 Xenopus laevis transcribed sequence with moderate similarity more 78.98(n)    CF285902.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc85a112 Transcribed sequence with moderate similarity to protein more 79.97(n)    BI709020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trap11 , 3 chaperone3
    CG3152-PA1
    52(a)3
    57.71(n)1
    54.4(a)1
      42C13
    355591  NM_058091.31  NP_477439.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R151.7b3
    R151.71
    Protein R151.71 48(a)
    (best of 2)3
    52.43(n)1
    47.52(a)1
      III(7295099-7298408)3
    1760191  NM_171881.41  NP_741220.21 


    ENSEMBL Gene Tree for TRAP1 (if available)
    TreeFam Gene Tree for TRAP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAP1 gene
    HSP90B12  HSP90AB12  HSP90AA12  
    5 SIMAP similar genes for TRAP1 using alignment to 12 protein entries:     TRAP1_HUMAN (see all proteins):
    HSP90AA2    HSP90B1    HSP90AB1    HSP90AA1    TRA1

    TRAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1389 NCBI SNPs in TRAP1 are shown (see all 1389    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504012641,2
    --3708628(+) AAGATA/CGCGCC 1 -- int10--------
    rs1381802541,2
    --3708631(+) ATCGCA/GCCACT 1 -- int10--------
    rs1821798121,2
    C--3708648(+) CAGCCC/TGGCAA 1 -- int10--------
    rs1120899571,2
    C--3708675(+) TCAAAAAAC/-  
            
    AAACA
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1999229501,2
    --3708687(+) CAAAC-/AAAACA 1 -- int10--------
    rs566820551,2
    C--3708694(+) ACAAA-/CAAA  
            
    AAGAC
    1 -- int10--------
    rs1846590021,2
    --3708702(+) GACAGA/GATTTT 1 -- int10--------
    rs1403967751,2
    --3708724(+) CTGTTC/GCACCC 1 -- int10--------
    rs1455726821,2
    C--3708758(+) TAGCCA/TGGGTC 1 -- int10--------
    rs1888059101,2
    C--3708798(+) CCTGAC/TCCACC 2 D G mis10--------

    HapMap Linkage Disequilibrium report for TRAP1 (3701640 - 3767598 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRAP1
         1 CNV: 49717

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRAP1 for disorders           About GeneDecksing

    OMIM gene information: 606219    OMIM disorders: --

    12 diseases for TRAP1:    About MalaCards
    hereditary multiple exostoses    exostoses    down syndrome    hepatocellular carcinoma
    retinoblastoma    prostate cancer    cerebritis    prostatitis
    tuberculosis    carcinoma    malaria    mycobacterium tuberculosis

    4 Novoseek disease relationships for TRAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 52.4 15 17513296 (2), 17579517 (1), 7876093 (1), 14596856 (1) (see all 5)
    necrosis 27.8 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)
    leukemia 13.8 2 15292218 (1), 14596856 (1)
    tumors 4.24 7 15292218 (2), 16927372 (2), 11010808 (2), 18784066 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRAP1 (8 documents)

    Export disorders for TRAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAP1 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with TRAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. (PubMed id 10652318)1, 2, 3, 9 Felts S.J.... Toft D.O. (2000)
    2. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PubMed id 7876093)1, 2, 3, 9 Song H.Y.... Donner D.B. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. (PubMed id 10545594)1, 2 Simmons A.D....Lovett M. (1999)
    5. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. (PubMed id 8756626)1, 2 Chen C.-F.... Lee W.-H. (1996)
    6. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)1, 9 Pridgeon J.W....Li L. (2007)
    7. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. (PubMed id 15292218)1, 9 Masuda Y....Nakaya K. (2004)
    8. Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. (PubMed id 16927372)1, 9 Im C.N....Seo J.S. (2007)
    9. Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro. (PubMed id 18091755)1, 9 Voloboueva L.A....Giffard R.G. (2008)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10131 HGNC: 16264 AceView: TRAP1 Ensembl:ENSG00000126602 euGenes: HUgn10131
    ECgene: TRAP1 H-InvDB: TRAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAP1 gene:
    Search GeneIP for patents involving TRAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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