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Aliases for TRANK1 Gene

Aliases for TRANK1 Gene

  • Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 2 3 5
  • Lupus Brain Antigen 1 Homolog 3 4
  • KIAA0342 2 4
  • LBA1 3 4
  • TPR And Ankyrin Repeat-Containing Protein 1 3
  • Lupus Brain Antigen 1 2

External Ids for TRANK1 Gene

Summaries for TRANK1 Gene

GeneCards Summary for TRANK1 Gene

TRANK1 (Tetratricopeptide Repeat And Ankyrin Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRANK1 Gene

Genomics for TRANK1 Gene

Regulatory Elements for TRANK1 Gene

Enhancers for TRANK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G036890 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +97.3 97304 5.4 PKNOX1 FOXA2 ATF1 WRNIP1 YBX1 YY1 ZNF766 CBX5 ZNF143 ZNF592 MLH1 EPM2AIP1 TRANK1 ENSG00000234073 DCLK3 GC03M036882
GH03G036922 1.5 Ensembl ENCODE dbSUPER 13.2 +67.1 67105 2.6 HDGF PKNOX1 ATF1 CREB3L1 ARNT ZBTB7B TCF12 ZNF766 CBX5 GATA2 LRRFIP2 TRANK1 GC03P036930 GC03M036882
GH03G036968 1.6 FANTOM5 Ensembl ENCODE 12.3 +21.1 21086 2.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 ELK1 GATA2 FOS LRRFIP2 EPM2AIP1 MLH1 TRANK1 GOLGA4 ITGA9 GC03M036969 ENSG00000272334
GH03G036905 1.6 FANTOM5 ENCODE dbSUPER 12.1 +83.4 83374 4.5 PKNOX1 ARNT ARID4B SIN3A YY1 GATA2 FOS CAVIN1 REST KAT8 TRANK1 LRRFIP2 EPM2AIP1 ENSG00000234073 GOLGA4 MLH1 GC03M036882 GC03P036930
GH03G036900 1.3 FANTOM5 ENCODE dbSUPER 13.7 +89.7 89714 1.8 PKNOX1 ZMYM3 ZNF384 GATA2 ADNP NR2F6 HES1 EZH2 SMARCE1 MTA2 TRANK1 RNU6ATAC4P EPM2AIP1 MLH1 ENSG00000234073 GOLGA4 GC03M036882 GC03P036930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRANK1 on UCSC Golden Path with GeneCards custom track

Promoters for TRANK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303459 181 401 BRD4 POLR2H MTA2 CHD1 RBFOX2
ENSR00000150822 681 201 BRD4 POLR2H MTA2 THRAP3
ENSR00000303460 -1919 3001 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for TRANK1 Gene

Chromosome:
3
Start:
36,826,817 bp from pter
End:
36,990,981 bp from pter
Size:
164,165 bases
Orientation:
Minus strand

Genomic View for TRANK1 Gene

Genes around TRANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRANK1 Gene

Proteins for TRANK1 Gene

  • Protein details for TRANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15050-TRNK1_HUMAN
    Recommended name:
    TPR and ankyrin repeat-containing protein 1
    Protein Accession:
    O15050
    Secondary Accessions:
    • Q8N8K0

    Protein attributes for TRANK1 Gene

    Size:
    2925 amino acids
    Molecular mass:
    336221 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04838.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRANK1 Gene

Post-translational modifications for TRANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRANK1 Gene

Domains & Families for TRANK1 Gene

Suggested Antigen Peptide Sequences for TRANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRANK1: view

No data available for UniProtKB/Swiss-Prot for TRANK1 Gene

Function for TRANK1 Gene

Phenotypes for TRANK1 Gene

GenomeRNAi human phenotypes for TRANK1:
genes like me logo Genes that share phenotypes with TRANK1: view

Animal Model Products

CRISPR Products

miRNA for TRANK1 Gene

miRTarBase miRNAs that target TRANK1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRANK1 Gene

Localization for TRANK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRANK1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRANK1 Gene

Pathways & Interactions for TRANK1 Gene

SuperPathways for TRANK1 Gene

No Data Available

Interacting Proteins for TRANK1 Gene

Selected Interacting proteins: O15050-TRNK1_HUMAN for TRANK1 Gene via IID

Symbol External ID(s) Details
CBX2
CBX4

Gene Ontology (GO) - Biological Process for TRANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRANK1 Gene

Drugs & Compounds for TRANK1 Gene

No Compound Related Data Available

Transcripts for TRANK1 Gene

Unigene Clusters for TRANK1 Gene

Tetratricopeptide repeat and ankyrin repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRANK1 Gene

No ASD Table

Relevant External Links for TRANK1 Gene

GeneLoc Exon Structure for
TRANK1
ECgene alternative splicing isoforms for
TRANK1

Expression for TRANK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRANK1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for TRANK1 Gene

This gene is overexpressed in Heart (46.3) and Plasma (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRANK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRANK1 Gene:

TRANK1

SOURCE GeneReport for Unigene cluster for TRANK1 Gene:

Hs.170999

Evidence on tissue expression from TISSUES for TRANK1 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TRANK1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRANK1 Gene

Orthologs for TRANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRANK1 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia TRANK1 34 35
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Trank1 34 16 35
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Trank1 34
  • 83.91 (n)
cow
(Bos Taurus)
Mammalia TRANK1 34 35
  • 83.75 (n)
oppossum
(Monodelphis domestica)
Mammalia TRANK1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRANK1 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRANK1 34 35
  • 63.26 (n)
lizard
(Anolis carolinensis)
Reptilia TRANK1 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trank1 34
  • 56.2 (n)
Species where no ortholog for TRANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRANK1 Gene

ENSEMBL:
Gene Tree for TRANK1 (if available)
TreeFam:
Gene Tree for TRANK1 (if available)

Paralogs for TRANK1 Gene

No data available for Paralogs for TRANK1 Gene

Variants for TRANK1 Gene

Sequence variations from dbSNP and Humsavar for TRANK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000004131 -- 36,850,443(+) CATTA(C/T)GACTA intron-variant, nc-transcript-variant
rs1000046533 -- 36,934,409(+) GGTTA(C/G)TAAGC intron-variant
rs1000097432 -- 36,864,590(+) GCAGT(A/G)TGACT intron-variant
rs1000128811 -- 36,902,930(+) ACATG(C/T)CCCAT intron-variant
rs1000184508 -- 36,860,575(+) CCAGA(A/C/G)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRANK1 Gene

Variant ID Type Subtype PubMed ID
esv1503716 CNV insertion 17803354
esv2725156 CNV deletion 23290073
nsv1112382 CNV deletion 24896259
nsv1152078 CNV deletion 26484159
nsv3762 CNV insertion 18451855
nsv473639 CNV novel sequence insertion 20440878
nsv590067 CNV loss 21841781
nsv834660 CNV loss 17160897
nsv834661 CNV loss 17160897
nsv834662 CNV loss 17160897
nsv998118 CNV loss 25217958

Variation tolerance for TRANK1 Gene

Residual Variation Intolerance Score: 0.572% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRANK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRANK1 Gene

Disorders for TRANK1 Gene

Relevant External Links for TRANK1

Genetic Association Database (GAD)
TRANK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRANK1

No disorders were found for TRANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRANK1 Gene

Publications for TRANK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Genome-wide association study reveals two new risk loci for bipolar disorder. (PMID: 24618891) MA1hleisen T.W. … Cichon S. (Nat Commun 2014) 3 64
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  5. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. (PMID: 22182935) Chen D.T. … Schulze T.G. (Mol. Psychiatry 2013) 3 64

Products for TRANK1 Gene

Sources for TRANK1 Gene

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