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Aliases for TRANK1 Gene

Aliases for TRANK1 Gene

  • Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 2 3 5
  • Lupus Brain Antigen 1 Homolog 3 4
  • KIAA0342 2 4
  • LBA1 3 4
  • Lupus Brain Antigen 1 2

External Ids for TRANK1 Gene

Summaries for TRANK1 Gene

GeneCards Summary for TRANK1 Gene

TRANK1 (Tetratricopeptide Repeat And Ankyrin Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRANK1 Gene

Genomics for TRANK1 Gene

Regulatory Elements for TRANK1 Gene

Enhancers for TRANK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRANK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRANK1 Gene

Chromosome:
3
Start:
36,826,817 bp from pter
End:
36,990,981 bp from pter
Size:
164,165 bases
Orientation:
Minus strand

Genomic View for TRANK1 Gene

Genes around TRANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRANK1 Gene

Proteins for TRANK1 Gene

  • Protein details for TRANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15050-TRNK1_HUMAN
    Recommended name:
    TPR and ankyrin repeat-containing protein 1
    Protein Accession:
    O15050
    Secondary Accessions:
    • Q8N8K0

    Protein attributes for TRANK1 Gene

    Size:
    2925 amino acids
    Molecular mass:
    336221 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04838.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRANK1 Gene

Proteomics data for TRANK1 Gene at MOPED

Post-translational modifications for TRANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRANK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRANK1 Gene

Domains & Families for TRANK1 Gene

Suggested Antigen Peptide Sequences for TRANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15050

UniProtKB/Swiss-Prot:

TRNK1_HUMAN :
  • Contains 6 ANK repeats.
Similarity:
  • Contains 6 ANK repeats.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TRANK1: view

Function for TRANK1 Gene

Gene Ontology (GO) - Molecular Function for TRANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TRANK1: view

Phenotypes for TRANK1 Gene

GenomeRNAi human phenotypes for TRANK1:
genes like me logo Genes that share phenotypes with TRANK1: view

Animal Model Products

CRISPR Products

miRNA for TRANK1 Gene

miRTarBase miRNAs that target TRANK1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRANK1 Gene

Localization for TRANK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRANK1 Gene COMPARTMENTS Subcellular localization image for TRANK1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRANK1 Gene

Pathways & Interactions for TRANK1 Gene

SuperPathways for TRANK1 Gene

No Data Available

Interacting Proteins for TRANK1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000416168%0d%0a9606.ENSP00000269397%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: ENSP00000416168 for TRANK1 Gene via STRING

Gene Ontology (GO) - Biological Process for TRANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRANK1 Gene

Drugs & Compounds for TRANK1 Gene

No Compound Related Data Available

Transcripts for TRANK1 Gene

Unigene Clusters for TRANK1 Gene

Tetratricopeptide repeat and ankyrin repeat containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRANK1 Gene

No ASD Table

Relevant External Links for TRANK1 Gene

GeneLoc Exon Structure for
TRANK1
ECgene alternative splicing isoforms for
TRANK1

Expression for TRANK1 Gene

mRNA expression in normal human tissues for TRANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRANK1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for TRANK1 Gene

This gene is overexpressed in Heart (46.3) and Plasma (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRANK1 Gene



SOURCE GeneReport for Unigene cluster for TRANK1 Gene Hs.170999

genes like me logo Genes that share expression patterns with TRANK1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRANK1 Gene

Orthologs for TRANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRANK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRANK1 35
  • 83.75 (n)
  • 81.81 (a)
TRANK1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRANK1 35
  • 87.69 (n)
  • 88.22 (a)
TRANK1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trank1 35
  • 84.12 (n)
  • 83.83 (a)
Trank1 16
Trank1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRANK1 35
  • 99.66 (n)
  • 99.69 (a)
TRANK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trank1 35
  • 83.91 (n)
  • 83.51 (a)
oppossum
(Monodelphis domestica)
Mammalia TRANK1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRANK1 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRANK1 35
  • 63.26 (n)
  • 59.37 (a)
TRANK1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRANK1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trank1 35
  • 56.2 (n)
  • 49.67 (a)
Species with no ortholog for TRANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRANK1 Gene

ENSEMBL:
Gene Tree for TRANK1 (if available)
TreeFam:
Gene Tree for TRANK1 (if available)

Paralogs for TRANK1 Gene

No data available for Paralogs for TRANK1 Gene

Variants for TRANK1 Gene

Sequence variations from dbSNP and Humsavar for TRANK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17201603 -, - 36,857,482(+) AAGAC(A/G)GATCC nc-transcript-variant, reference, missense
rs11712950 - 36,856,321(+) CCTCC(C/T)CCTCT nc-transcript-variant, reference, missense
rs4789 -- 36,827,948(-) ATGAC(A/G)TGAGT utr-variant-3-prime
rs7514 -- 36,826,877(-) AGAAA(A/C)CCCCA utr-variant-3-prime
rs13421 -- 36,944,388(+) CCAGG(A/C/G/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRANK1 Gene

Variant ID Type Subtype PubMed ID
nsv834660 CNV Loss 17160897
nsv834661 CNV Loss 17160897
nsv3762 CNV Insertion 18451855
nsv834662 CNV Loss 17160897
esv1503716 CNV Insertion 17803354
esv2725156 CNV Deletion 23290073

Variation tolerance for TRANK1 Gene

Residual Variation Intolerance Score: 0.572% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRANK1 Gene

Disorders for TRANK1 Gene

Relevant External Links for TRANK1

Genetic Association Database (GAD)
TRANK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRANK1

No disorders were found for TRANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRANK1 Gene

Publications for TRANK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Genome-wide association study reveals two new risk loci for bipolar disorder. (PMID: 24618891) MA1hleisen T.W. … Cichon S. (Nat Commun 2014) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. (PMID: 22182935) Chen D.T. … Schulze T.G. (Mol. Psychiatry 2013) 3
  5. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. (PMID: 24280982) Ruderfer D.M. … Kendler K.S. (Mol. Psychiatry 2013) 3

Products for TRANK1 Gene

Sources for TRANK1 Gene

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