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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRANK1 Gene

protein-coding GIFtS: 39
GCID: GC03M036845

tetratricopeptide repeat and ankyrin repeat containing 1

Search for TRANK1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tetratricopeptide Repeat And Ankyrin Repeat Containing 1¹ ²
LBA1¹ ² ³
KIAA0342¹ ³
Lupus Brain Antigen 1 Homolog² ³
TPR And Ankyrin Repeat-Containing Protein 1²

External Ids:	HGNC: 29011¹	Entrez Gene: 9881²	Ensembl: ENSG00000168016⁷	UniProtKB: O15050³

Export aliases for TRANK1 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TRANK1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TRANK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRANK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22.2

TRANK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRANK1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M036845: view genomic region (about GC identifiers)

Start:	36,868,308 bp from pter	End:	36,986,548 bp from pter
Size:	118,241 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRNK1_HUMAN, O15050 (See protein sequence)

Recommended Name: TPR and ankyrin repeat-containing protein 1

Size: 2925 amino acids; 336221 Da

Sequence caution: Sequence=BAC04838.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q8N8K0

Explore the universe of human proteins at neXtProt for TRANK1: NX_O15050

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15050

TRANK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055646.2

ENSEMBL proteins:

ENSP00000416826 ENSP00000416168 ENSP00000301807

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRANK1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011990 TPR-like_helical

IPR014016 UvrD-like_ATP-bd

IPR014017 DNA_helicase_UvrD-like_C

IPR020683 Ankyrin_rpt-contain_dom

IPR013026 TPR-contain_dom

Graphical View of Domain Structure for InterPro Entry O15050

ProtoNet protein and cluster: O15050

1 Blocks protein family: IPB000515 Binding-protein-dependent transport systems inner membrane component

UniProtKB/Swiss-Prot: TRNK1_HUMAN, O15050

Similarity: Contains 6 ANK repeats

Similarity: Contains 4 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0004003	ATP-dependent DNA helicase activity	--	--
GO:0005524	ATP binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

TRANK1 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRANK1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TRANK1 (ENSP00000301807⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBX2	ENSP00000308750⁴	STRING: ENSP00000308750

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRANK1
Search CenterWatch for drugs/clinical trials and news about TRANK1 / TRNK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TRANK1 gene:

NM_014831.2

Unigene Cluster for TRANK1:

Tetratricopeptide repeat and ankyrin repeat containing 1

Hs.170999 [show with all ESTs]

Unigene Representative Sequence: NM_014831

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428977 ENST00000463984 ENST00000513141 ENST00000505962 ENST00000463764

ENST00000511973 ENST00000429976 ENST00000301807(uc003cgj.3)

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		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate TRANK1 (see all 47):
		hsa-let-7d hsa-miR-15a hsa-miR-449a hsa-miR-374c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-15b

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Additional cDNA sequence:

AB002340.3 AK096678.1

4 DOTS entries:

DT.97776499 DT.120859625 DT.40301196 DT.97800817

24/278 AceView cDNA sequences (see all 278):

BX506234 BQ057126 AB002340 BE220141 BG214347 CA307101 BQ956036 BQ063413

BQ057251 BQ062307 BE836761 AA738434 BM564026 BQ064128 BQ058918 AI925555

BQ056618 AW505091 BQ024165 BQ643228 BQ066687 AI702802 BX951385 AI744282

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRANK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTTGTTG

About this image

TRANK1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Neural Tube

Neural Tube

Spinal Dorsal Columns

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRANK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRANK1

SOURCE GeneReport for Unigene cluster: Hs.170999

SABiosciences Custom PCR Arrays for TRANK1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRANK1 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trank1^{1 , 5}	tetratricopeptide repeat and ankyrin repeat containing more^{1, 5}	84.12(n)¹ 83.83(a)¹		9 (60.95 cM)⁵ 320429¹ NM_001164659.1¹ NP_001158131.1¹ 111311739⁵
chicken (Gallus gallus)	Aves	TRANK1¹	tetratricopeptide repeat and ankyrin repeat containing more	63.32(n) 59.42(a)		420728 XM_418827.3 XP_418827.3
lizard (Anolis carolinensis)	Reptilia	TRANK1⁶	--	56(a)	1 ↔ 1	6(43527357-43605654)

ENSEMBL Gene Tree for TRANK1 (if available)
TreeFam Gene Tree for TRANK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs33954737^1,2	C	--	36817382(+)	`GTCTC-/AAAAAA`	1	--	int¹		1		NA	2
rs34540496^1,2	C	--	36847083(+)	`TTTGG-/TTTTTT`	1	--	int¹		2		NA	4
rs183008161^1,2		--	36867936(+)	`TTGAAC/TAGACC`	1	--	int¹		0	--	--	--	--
rs148206247^1,2		--	36868060(+)	`CAAAAC/TTCCTT`	1	--	int¹		0	--	--	--	--
rs115986180^1,2	F	--	36868097(+)	`GCATCC/TAGATT`	1	--	int¹		1		WA	118
rs77485756^1,2	F	--	36868175(+)	`TCTCTA/GTCCCT`	1	--	int¹		1		WA	118
rs185773927^1,2		--	36868229(+)	`CAGCAC/TCAATC`	1	--	int¹		0	--	--	--	--
rs190287639^1,2		--	36868290(+)	`AGACTA/GGAAAT`	1	--	int¹		0	--	--	--	--
rs141145733^1,2		--	36868300(+)	`TAAAAC/TGGCAG`	1	--	int¹		0	--	--	--	--
rs150914332^1,2		--	36868301(+)	`AAAACA/GGCAGC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRANK1 (36868308 - 36986548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRANK1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRANK1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRANK1)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{1, 2, 3} Nagase T.... Ohara O. (1997)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Genome-wide association study meta-analysis of Europea n and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. (PubMed id 22182935)¹ Chen D.T....Schulze T.G. (2013)
Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)¹ Sklar P....Purcell S.M. (2011)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)² Nakajima D.... Nagase T. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9881	HGNC: 29011	AceView: KIAA0342	Ensembl:ENSG00000168016	euGenes: HUgn9881
ECgene: TRANK1	H-InvDB: TRANK1

(According to HUGE)
About This Section

HUGE: KIAA0342

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRANK1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRANK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRANK1 gene:
Search GeneIP for patents involving TRANK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TRANK1 Gene

tetratricopeptide repeat and ankyrin repeat containing 1

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Export list of displayed genes

TRANK1 Gene

tetratricopeptide repeat and ankyrin repeat containing 1

Aliasesfor TRANK1 gene

Summariesfor TRANK1 gene

Genomic Viewsfor TRANK1 gene

Proteinsfor TRANK1 gene

Protein Domains /Familiesfor TRANK1 gene

Functionfor TRANK1 gene

Pathways & Interactionsfor TRANK1 gene

Drugs & Compoundsfor TRANK1 gene

Transcriptsfor TRANK1 gene

Expression for TRANK1 gene

Orthologsfor TRANK1 gene

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Genomic Variantsfor TRANK1 gene

Disorders / Diseasesfor TRANK1 gene

Publicationsfor TRANK1 gene

External Searches for TRANK1 gene

Genome Databases showing TRANK1 gene

Other Databases showing TRANK1 gene

Specialized Databases showing TRANK1 gene

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Productsfor TRANK1 gene

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Aliases
for TRANK1 gene

Summaries
for TRANK1 gene

Genomic Views
for TRANK1 gene

Proteins
for TRANK1 gene

Protein Domains /
Families
for TRANK1 gene

Function
for TRANK1 gene

Pathways & Interactions
for TRANK1 gene

Drugs & Compounds
for TRANK1 gene

Transcripts
for TRANK1 gene

Expression
for TRANK1 gene

Orthologs
for TRANK1 gene

Paralogs
for TRANK1 gene

Genomic Variants
for TRANK1 gene

Disorders / Diseases
for TRANK1 gene

Publications
for TRANK1 gene

Intellectual Property
for TRANK1 gene

Products
for TRANK1 gene