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Aliases for TRANK1 Gene

Aliases for TRANK1 Gene

  • Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 2 3
  • Lupus Brain Antigen 1 Homolog 3 4
  • KIAA0342 2 4
  • LBA1 3 4
  • TPR And Ankyrin Repeat-Containing Protein 1 3
  • Lupus Brain Antigen 1 2

External Ids for TRANK1 Gene

Summaries for TRANK1 Gene

GeneCards Summary for TRANK1 Gene

TRANK1 (Tetratricopeptide Repeat And Ankyrin Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRANK1 Gene

Genomics for TRANK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRANK1 Gene

Start:
36,826,817 bp from pter
End:
36,945,057 bp from pter
Size:
118,241 bases
Orientation:
Minus strand

Genomic View for TRANK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRANK1 Gene

No data available for Regulatory Elements for TRANK1 Gene

Proteins for TRANK1 Gene

  • Protein details for TRANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15050-TRNK1_HUMAN
    Recommended name:
    TPR and ankyrin repeat-containing protein 1
    Protein Accession:
    O15050
    Secondary Accessions:
    • Q8N8K0

    Protein attributes for TRANK1 Gene

    Size:
    2925 amino acids
    Molecular mass:
    336221 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04838.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TRANK1 Gene

Proteomics data for TRANK1 Gene at MOPED

Post-translational modifications for TRANK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRANK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRANK1 Gene

Domains for TRANK1 Gene

Gene Families for TRANK1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Suggested Antigen Peptide Sequences for TRANK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15050

UniProtKB/Swiss-Prot:

TRNK1_HUMAN :
  • O15050
Similarity:
  • Contains 6 ANK repeats.
  • Contains 4 TPR repeats.
genes like me logo Genes that share domains with TRANK1: view

Function for TRANK1 Gene

Gene Ontology (GO) - Molecular Function for TRANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TRANK1: view

Animal Model Products

CRISPR Products

miRNA for TRANK1 Gene

miRTarBase miRNAs that target TRANK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRANK1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRANK1 Gene

Localization for TRANK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRANK1 Gene COMPARTMENTS Subcellular localization image for TRANK1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRANK1 Gene

Pathways for TRANK1 Gene

SuperPathways for TRANK1 Gene

No Data Available

Interacting Proteins for TRANK1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000416168%0d%0a9606.ENSP00000269397%0d%0a9606.ENSP00000250495%0d%0a
Selected Interacting proteins: ENSP00000416168 for TRANK1 Gene via STRING

Gene Ontology (GO) - Biological Process for TRANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TRANK1: view

No data available for Pathways by source for TRANK1 Gene

Transcripts for TRANK1 Gene

mRNA/cDNA for TRANK1 Gene

Unigene Clusters for TRANK1 Gene

Tetratricopeptide repeat and ankyrin repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRANK1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRANK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRANK1 Gene

No ASD Table

Relevant External Links for TRANK1 Gene

GeneLoc Exon Structure for
TRANK1
ECgene alternative splicing isoforms for
TRANK1

Expression for TRANK1 Gene

mRNA expression in normal human tissues for TRANK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRANK1 Gene

This gene is overexpressed in Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRANK1 Gene

SOURCE GeneReport for Unigene cluster for TRANK1 Gene Hs.170999

genes like me logo Genes that share expressions with TRANK1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRANK1 Gene

Orthologs for TRANK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRANK1 35
  • 99.66 (n)
  • 99.69 (a)
TRANK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRANK1 35
  • 83.75 (n)
  • 81.81 (a)
TRANK1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRANK1 35
  • 87.69 (n)
  • 88.22 (a)
TRANK1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trank1 35
  • 84.12 (n)
  • 83.83 (a)
Trank1 16
Trank1 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRANK1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRANK1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trank1 35
  • 83.91 (n)
  • 83.51 (a)
chicken
(Gallus gallus)
Aves TRANK1 35
  • 63.26 (n)
  • 59.37 (a)
TRANK1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRANK1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trank1 35
  • 56.2 (n)
  • 49.67 (a)
Species with no ortholog for TRANK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRANK1 Gene

ENSEMBL:
Gene Tree for TRANK1 (if available)
TreeFam:
Gene Tree for TRANK1 (if available)

Paralogs for TRANK1 Gene

No data available for Paralogs for TRANK1 Gene

Variants for TRANK1 Gene

Sequence variations from dbSNP and Humsavar for TRANK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4789 -- 36,827,948(-) ATGAC(A/G)TGAGT utr-variant-3-prime
rs7514 -- 36,826,877(-) AGAAA(A/C)CCCCA utr-variant-3-prime
rs13421 -- 36,944,388(+) CCAGG(A/C/G/T)TTCTG intron-variant
rs717733 -- 36,894,261(-) AGTGT(A/G)GGGTG intron-variant
rs717734 -- 36,894,253(-) GTGGA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRANK1 Gene

Variant ID Type Subtype PubMed ID
nsv834660 CNV Loss 17160897
nsv834661 CNV Loss 17160897
nsv3762 CNV Insertion 18451855
nsv834662 CNV Loss 17160897
esv1503716 CNV Insertion 17803354
esv2725156 CNV Deletion 23290073

Relevant External Links for TRANK1 Gene

HapMap Linkage Disequilibrium report
TRANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRANK1 Gene

Disorders for TRANK1 Gene

Relevant External Links for TRANK1

Genetic Association Database (GAD)
TRANK1
genes like me logo Genes that share disorders with TRANK1: view

No data available for UniProtKB/Swiss-Prot for TRANK1 Gene

Publications for TRANK1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3
  5. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3

Products for TRANK1 Gene

Sources for TRANK1 Gene

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