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TRAM2 Gene

protein-coding   GIFtS: 54
GCID: GC06M052363

Translocation Associated Membrane Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocation Associated Membrane Protein 21 2
KIAA00573 5
TRAM-Like Protein2
Translocating Chain-Associated Membrane Protein 22

External Ids:    HGNC: 168551   Entrez Gene: 96972   Ensembl: ENSG000000653087   OMIM: 6084855   UniProtKB: Q150353   

Export aliases for TRAM2 gene to outside databases

Previous GC identifers: GC06M052358 GC06M052409 GC06M052414 GC06M052470 GC06U900790 GC06M052193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAM2 Gene:
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational
processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.(supplied by
OMIM, Jul 2004)

GeneCards Summary for TRAM2 Gene:
TRAM2 (translocation associated membrane protein 2) is a protein-coding gene. Diseases associated with TRAM2 include polycystic kidney and hepatic disease, and juvenile myoclonic epilepsy. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot: TRAM2_HUMAN, Q15035
Function: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the
activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen
synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in
collagen folding

Gene Wiki entry for TRAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAM2 gene promoter:
         Tal-1   NF-AT   PPAR-gamma1   NF-AT4   GATA-6   NF-AT2   ARP-1   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAM2 promoter sequence
   Search Chromatin IP Primers for TRAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1-p12   Ensembl cytogenetic band:  6p12.2   HGNC cytogenetic band: 6p21.1-p12

TRAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052363:  view genomic region     (about GC identifiers)

Start:
52,362,200 bp from pter      End:
52,441,862 bp from pter
Size:
79,663 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRAM2_HUMAN, Q15035 (See protein sequence)
Recommended Name: Translocating chain-associated membrane protein 2  
Size: 370 amino acids; 43328 Da
Subunit: Interacts with SERCA2B and COL1A1
Sequence caution: Sequence=BAA06540.2; Type=Erroneous initiation;
Secondary accessions: A8K6T6

Explore the universe of human proteins at neXtProt for TRAM2: NX_Q15035

Explore proteomics data for TRAM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn55
  • Modification sites at PhosphoSitePlus

  • See TRAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036420.1  
    ENSEMBL proteins: 
     ENSP00000182527  

    TRAM2 Human Recombinant Protein Products:

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    Novus Biologicals TRAM2 Proteins
    Novus Biologicals TRAM2 Lysate
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    Cloud-Clone Corp. Proteins for TRAM2

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    TRAM2 Assay Products:

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    Cloud-Clone Corp. CLIAs for TRAM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016447 Translocation_assoc_membrane
     IPR013599 TRAM1
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q15035

    ProtoNet protein and cluster: Q15035

    3 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM
    IPB013599 TRAM1-like protein


    UniProtKB/Swiss-Prot: TRAM2_HUMAN, Q15035
    Similarity: Belongs to the TRAM family
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    TRAM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAM2_HUMAN, Q15035
    Function: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the
    activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen
    synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in
    collagen folding

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14749390
         
    TRAM2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRAM2:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tram2):
     hearing/vestibular/ear 

    TRAM2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAM2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRAM2:
    hsa-mir-98-5p (MIRT027751), hsa-mir-122-5p (MIRT023369), hsa-mir-26b-5p (MIRT029785), hsa-mir-7-5p (MIRT025874)

    Block miRNA regulation of human, mouse, rat TRAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAM2 (see all 91):
    hsa-miR-579 hsa-miR-548j hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat TRAM2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TRAM2 (NM_012288)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAM2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRAM2_HUMAN, Q15035: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    golgi apparatus2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TRAM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRAM2
    Interactions:

        Search GeneGlobe Interaction Network for TRAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TRAM2 (Q150353 ENSP000001825274) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2F2P139843, ENSP000003408234I2D: score=2 STRING: ENSP00000340823
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    GTF2BQ004033, ENSP000003595314I2D: score=2 STRING: ENSP00000359531
    CREBBPQ927933I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0032964collagen biosynthetic process IMP14749390

    TRAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAM2 gene: 
    NM_012288.3  

    Unigene Cluster for TRAM2:

    Translocation associated membrane protein 2
    Hs.520182  [show with all ESTs]
    Unigene Representative Sequence: NM_012288
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000182527(uc003paq.3 uc003par.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRAM2 (see all 91):
    hsa-miR-579 hsa-miR-548j hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148 hsa-miR-92b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRAM2
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    OriGene ORF clones in mouse, rat for TRAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAM2 (NM_012288)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAM2
    Primer
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    OriGene qPCR primer pairs and template standards for TRAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAM2
      QuantiTect SYBR Green Assays in human, mouse, rat TRAM2
      QuantiFast Probe-based Assays in human, mouse, rat TRAM2

    Additional mRNA sequence: 

    AB621814.1 AK291751.1 AK311560.1 AY927571.1 AY927606.1 AY927607.1 BC016804.1 BC028121.1 
    D31762.1 

    7 DOTS entries:

    DT.92445813  DT.40214424  DT.92445815  DT.101973563  DT.121368638  DT.75173504  DT.100667495 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAAAAGGG
    TRAM2 Expression
    About this image

    TRAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520182
        Custom PCR Arrays for TRAM2
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    QuantiFast Probe-based Assays in human, mouse, rat TRAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRAM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tram21 , 5 translocating chain-associating membrane protein 21, 5 88.65(n)1
    90(a)1
      1 (6.50 cM)5
    1708291  NM_177409.31  NP_803128.11 
     209962965 
    chicken
    (Gallus gallus)
    Aves TRAM21 translocation associated membrane protein 2 77.95(n)
    79.15(a)
      422040  XM_420046.4  XP_420046.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRAM26
    translocation associated membrane protein 2
    82(a)
    1 ↔ 1
    1(122954816-122991616)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tram21 translocation associated membrane protein 2 73.08(n)
    74.8(a)
      100216032  NM_001142021.1  NP_001135493.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.48112 Danio rerio mRNA similar to TRAM-like protein (cDNA more 73.16(n)    BC046900.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TRAM6
    TRAM
    35(a)
    1 → many
    X(829265-831855)
    worm
    (Caenorhabditis elegans)
    Secernentea tram-16
    Protein TRAM-1, isoform a (tram-1) mRNA, complete ...
    34(a)
    1 → many
    IV(10219431-10221281) WBGene00007696


    ENSEMBL Gene Tree for TRAM2 (if available)
    TreeFam Gene Tree for TRAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAM2 gene
    TRAM12  TRAM1L12  
    2 SIMAP similar genes for TRAM2 using alignment to 2 protein entries:     TRAM2_HUMAN (see all proteins):
    TRAM1    TRAM1L1

    TRAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAM2 (see all 1699)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs676466461,2
    C--52246920(-) CACTT-/TGGGAGG
    CCAAGGCAGG
    TGGGA
    1 -- int11Minor allele frequency- TGGGAGGCCAAGGCAGG:0.00NA 2
    rs1845553211,2
    --52361766(+) CCACTA/GTTACT 1 -- ds50010--------
    rs1420179501,2
    --52361793(+) CTAGTC/TAGCAC 1 -- ds50010--------
    rs1152298741,2
    C,F--52361826(+) ACAAAC/TGAAAC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs759495811,2
    F--52361830(+) ACGAAA/GCCCCA 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs94637931,2
    C,F,A,H--52361921(+) CCCCAT/CGTTAA 1 -- ds500112Minor allele frequency- C:0.11NS EA NA WA 1200
    rs1411706591,2
    C--52361933(+) AAACC-/TCTTCTTT 1 -- cds10--------
    rs608981921,2
    C--52361934(+) AACCT-/CT    
       T
    /TCT
    CTTTT
    2 -- cds10--------
    rs1430922851,2
    --52362013(+) CTCCAG/TCCTTA 1 -- ds50010--------
    rs93701251,2
    C,F,H--52362035(+) CATATC/TACAAT 1 -- ds500117Minor allele frequency- T:0.11NA NS EA WA 1510

    HapMap Linkage Disequilibrium report for TRAM2 (52362200 - 52441862 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732081CNV Deletion23290073
    esv2732082CNV Deletion23290073
    nsv522674CNV Loss19592680
    nsv830663CNV Loss17160897
    nsv527895CNV Loss19592680
    nsv518713CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608485    OMIM disorders: --

    5 diseases for TRAM2:    About MalaCards
    polycystic kidney and hepatic disease    juvenile myoclonic epilepsy    polycystic kidney disease    kidney disease
    hepatitis


    TRAM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRAM2
    Human Genome Epidemiology (HuGE) Navigator: TRAM2 (2 documents)

    Export disorders for TRAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAM2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TRAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    2. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. (PubMed id 14749390)1, 2, 9 Stefanovic B.... Brenner D.A. (Mol. Cell. Biol. 2004)
    3. Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (PubMed id 10594243)1, 3, 9 Onuchic L.F....Guay-Woodford L.M. (Mamm. Genome 1999)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9697 HGNC: 16855 Ensembl:ENSG00000065308 euGenes: HUgn9697 ECgene: TRAM2
    H-InvDB: TRAM2

    (According to HUGE)
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    HUGE: KIAA0057

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRAM2 gene:
    Search GeneIP for patents involving TRAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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