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Aliases for TRAM1L1 Gene

Aliases for TRAM1L1 Gene

  • Translocation Associated Membrane Protein 1-Like 1 2 3

External Ids for TRAM1L1 Gene

Previous GeneCards Identifiers for TRAM1L1 Gene

  • GC04M118463
  • GC04M118362
  • GC04M118224
  • GC04M118004
  • GC04M113738

Summaries for TRAM1L1 Gene

GeneCards Summary for TRAM1L1 Gene

TRAM1L1 (Translocation Associated Membrane Protein 1-Like 1) is a Protein Coding gene. Diseases associated with TRAM1L1 include alcohol dependence. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot for TRAM1L1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM1L1 Gene

Genomics for TRAM1L1 Gene

Regulatory Elements for TRAM1L1 Gene

Genomic Location for TRAM1L1 Gene

Start:
117,083,554 bp from pter
End:
117,085,580 bp from pter
Size:
2,027 bases
Orientation:
Minus strand

Genomic View for TRAM1L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1L1 Gene

Proteins for TRAM1L1 Gene

  • Protein details for TRAM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N609-TR1L1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1-like 1
    Protein Accession:
    Q8N609
    Secondary Accessions:
    • Q8N2L7

    Protein attributes for TRAM1L1 Gene

    Size:
    369 amino acids
    Molecular mass:
    42162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAM1L1 Gene

Proteomics data for TRAM1L1 Gene at MOPED

Post-translational modifications for TRAM1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAM1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAM1L1 Gene

Domains for TRAM1L1 Gene

Suggested Antigen Peptide Sequences for TRAM1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N609

UniProtKB/Swiss-Prot:

TR1L1_HUMAN :
  • Q8N609
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1L1: view

No data available for Gene Families for TRAM1L1 Gene

Function for TRAM1L1 Gene

Molecular function for TRAM1L1 Gene

UniProtKB/Swiss-Prot Function: Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Phenotypes for TRAM1L1 Gene

GenomeRNAi human phenotypes for TRAM1L1:
genes like me logo Genes that share phenotypes with TRAM1L1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAM1L1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAM1L1 Gene

Localization for TRAM1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAM1L1 Gene COMPARTMENTS Subcellular localization image for TRAM1L1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAM1L1: view

Pathways for TRAM1L1 Gene

SuperPathways for TRAM1L1 Gene

No Data Available

Interacting Proteins for TRAM1L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309402%0d%0a9606.ENSP00000223641%0d%0a
Selected Interacting proteins: ENSP00000309402 for TRAM1L1 Gene via STRING

Symbol External ID(s) Details
SEC61B

Gene Ontology (GO) - Biological Process for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with TRAM1L1: view

No data available for Pathways by source for TRAM1L1 Gene

Transcripts for TRAM1L1 Gene

mRNA/cDNA for TRAM1L1 Gene

(20) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAM1L1 Gene

Translocation associated membrane protein 1-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAM1L1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1L1 Gene

No ASD Table

Relevant External Links for TRAM1L1 Gene

GeneLoc Exon Structure for
TRAM1L1
ECgene alternative splicing isoforms for
TRAM1L1

Expression for TRAM1L1 Gene

mRNA expression in normal human tissues for TRAM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRAM1L1 Gene

SOURCE GeneReport for Unigene cluster for TRAM1L1 Gene Hs.570737

genes like me logo Genes that share expressions with TRAM1L1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAM1L1 Gene

Orthologs for TRAM1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAM1L1 35
  • 99.55 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRAM1L1 35
  • 81.02 (n)
  • 73.3 (a)
TRAM1L1 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAM1L1 35
  • 77.2 (n)
  • 79.29 (a)
TRAM1L1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tram1l1 35
  • 76.43 (n)
  • 75.41 (a)
Tram1l1 16
Tram1l1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 38 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tram1l1 35
  • 77.44 (n)
  • 76.24 (a)
chicken
(Gallus gallus)
Aves TRAM1 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tram1 36
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TRAM 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for TRAM1L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAM1L1 Gene

ENSEMBL:
Gene Tree for TRAM1L1 (if available)
TreeFam:
Gene Tree for TRAM1L1 (if available)

Paralogs for TRAM1L1 Gene

Paralogs for TRAM1L1 Gene

Selected SIMAP similar genes for TRAM1L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAM1L1: view

Variants for TRAM1L1 Gene

Sequence variations from dbSNP and Humsavar for TRAM1L1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7683927 -- 117,085,940(+) CCCAC(A/C)CCTTT upstream-variant-2KB
rs7683967 -- 117,086,000(+) TTCAC(A/C)TCCCT upstream-variant-2KB
rs7684412 -- 117,086,308(+) ACCTC(A/G)TATGT upstream-variant-2KB
rs7684784 -- 117,086,397(+) CAAGA(C/T)TGGAA upstream-variant-2KB
rs7684884 -- 117,086,267(+) ACAAA(G/T)CTCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAM1L1 Gene

Variant ID Type Subtype PubMed ID
nsv879753 CNV Loss 21882294

Relevant External Links for TRAM1L1 Gene

HapMap Linkage Disequilibrium report
TRAM1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Disorders for TRAM1L1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAM1L1 Gene including...

Search for TRAM1L1 Gene in MalaCards »

Relevant External Links for TRAM1L1

Genetic Association Database (GAD)
TRAM1L1
Human Genome Epidemiology (HuGE) Navigator
TRAM1L1
genes like me logo Genes that share disorders with TRAM1L1: view

No data available for UniProtKB/Swiss-Prot for TRAM1L1 Gene

Publications for TRAM1L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3 48
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 48
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for TRAM1L1 Gene

Sources for TRAM1L1 Gene

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