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Aliases for TRAM1L1 Gene

Aliases for TRAM1L1 Gene

  • Translocation Associated Membrane Protein 1-Like 1 2 3 5

External Ids for TRAM1L1 Gene

Previous GeneCards Identifiers for TRAM1L1 Gene

  • GC04M118463
  • GC04M118362
  • GC04M118224
  • GC04M118004
  • GC04M113738

Summaries for TRAM1L1 Gene

GeneCards Summary for TRAM1L1 Gene

TRAM1L1 (Translocation Associated Membrane Protein 1-Like 1) is a Protein Coding gene. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot for TRAM1L1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM1L1 Gene

Genomics for TRAM1L1 Gene

Regulatory Elements for TRAM1L1 Gene

Enhancers for TRAM1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRAM1L1 on UCSC Golden Path with GeneCards custom track

Promoters for TRAM1L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TRAM1L1 Gene

Chromosome:
4
Start:
117,083,554 bp from pter
End:
117,085,580 bp from pter
Size:
2,027 bases
Orientation:
Minus strand

Genomic View for TRAM1L1 Gene

Genes around TRAM1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1L1 Gene

Proteins for TRAM1L1 Gene

  • Protein details for TRAM1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N609-TR1L1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1-like 1
    Protein Accession:
    Q8N609
    Secondary Accessions:
    • Q8N2L7

    Protein attributes for TRAM1L1 Gene

    Size:
    369 amino acids
    Molecular mass:
    42162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAM1L1 Gene

Post-translational modifications for TRAM1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAM1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAM1L1 Gene

Domains & Families for TRAM1L1 Gene

Suggested Antigen Peptide Sequences for TRAM1L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N609

UniProtKB/Swiss-Prot:

TR1L1_HUMAN :
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TRAM family.
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1L1: view

No data available for Gene Families for TRAM1L1 Gene

Function for TRAM1L1 Gene

Molecular function for TRAM1L1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane.
genes like me logo Genes that share phenotypes with TRAM1L1: view

Animal Model Products

CRISPR Products

miRNA for TRAM1L1 Gene

miRTarBase miRNAs that target TRAM1L1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1L1 Gene

Localization for TRAM1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1L1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAM1L1 Gene COMPARTMENTS Subcellular localization image for TRAM1L1 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
mitochondrion 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005791 rough endoplasmic reticulum IBA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TRAM1L1: view

Pathways & Interactions for TRAM1L1 Gene

SuperPathways for TRAM1L1 Gene

No Data Available

Interacting Proteins for TRAM1L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309402%0d%0a9606.ENSP00000223641%0d%0a
Selected Interacting proteins: ENSP00000309402 Q8N609-TR1L1_HUMAN for TRAM1L1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TRAM1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane IBA --
genes like me logo Genes that share ontologies with TRAM1L1: view

No data available for Pathways by source and SIGNOR curated interactions for TRAM1L1 Gene

Drugs & Compounds for TRAM1L1 Gene

No Compound Related Data Available

Transcripts for TRAM1L1 Gene

mRNA/cDNA for TRAM1L1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAM1L1 Gene

Translocation associated membrane protein 1-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1L1 Gene

No ASD Table

Relevant External Links for TRAM1L1 Gene

GeneLoc Exon Structure for
TRAM1L1
ECgene alternative splicing isoforms for
TRAM1L1

Expression for TRAM1L1 Gene

mRNA expression in normal human tissues for TRAM1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1L1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRAM1L1 Gene



Protein tissue co-expression partners for TRAM1L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAM1L1 Gene:

TRAM1L1

SOURCE GeneReport for Unigene cluster for TRAM1L1 Gene:

Hs.570737
genes like me logo Genes that share expression patterns with TRAM1L1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAM1L1 Gene

Orthologs for TRAM1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAM1L1 34
  • 81.02 (n)
  • 73.3 (a)
TRAM1L1 35
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAM1L1 34
  • 77.2 (n)
  • 79.29 (a)
TRAM1L1 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tram1l1 34
  • 76.43 (n)
  • 75.41 (a)
Tram1l1 16
Tram1l1 35
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAM1L1 34
  • 99.55 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Tram1l1 34
  • 77.44 (n)
  • 76.24 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAM1 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tram1 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TRAM 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for TRAM1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAM1L1 Gene

ENSEMBL:
Gene Tree for TRAM1L1 (if available)
TreeFam:
Gene Tree for TRAM1L1 (if available)

Paralogs for TRAM1L1 Gene

Paralogs for TRAM1L1 Gene

(2) SIMAP similar genes for TRAM1L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAM1L1: view

Variants for TRAM1L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRAM1L1 Gene

Variant ID Type Subtype PubMed ID
esv3569670 CNV loss 25503493
nsv1008744 CNV loss 25217958

Variation tolerance for TRAM1L1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAM1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRAM1L1 Gene

Disorders for TRAM1L1 Gene

Relevant External Links for TRAM1L1

Genetic Association Database (GAD)
TRAM1L1
Human Genome Epidemiology (HuGE) Navigator
TRAM1L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAM1L1

No disorders were found for TRAM1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAM1L1 Gene

Publications for TRAM1L1 Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 65
  2. Common body mass index-associated variants confer risk of extreme obesity. (PMID: 19553259) Cotsapas C. … Daly M.J. (Hum. Mol. Genet. 2009) 3 46 65
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3 65

Products for TRAM1L1 Gene

Sources for TRAM1L1 Gene

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