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Aliases for TRAM1 Gene

Aliases for TRAM1 Gene

  • Translocation Associated Membrane Protein 1 2 3 5
  • TRAM 3 4
  • Translocating Chain-Associated Membrane Protein 1 3
  • Translocating Chain-Associating Membrane Protein 3
  • Translocation-Associating Membrane Protein 1 3
  • TRAMP 3
  • PNAS8 3

External Ids for TRAM1 Gene

Previous GeneCards Identifiers for TRAM1 Gene

  • GC08M071426
  • GC08M071208
  • GC08M071535
  • GC08M071648
  • GC08M066978

Summaries for TRAM1 Gene

Entrez Gene Summary for TRAM1 Gene

  • This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRAM1 Gene

TRAM1 (Translocation Associated Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Gene Expression. GO annotations related to this gene include receptor activity. An important paralog of this gene is TRAM1L1.

UniProtKB/Swiss-Prot for TRAM1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM1 Gene

Genomics for TRAM1 Gene

Regulatory Elements for TRAM1 Gene

Enhancers for TRAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G070147 1.5 Ensembl ENCODE dbSUPER 10.7 +460.0 460009 1.7 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 REST LACTB2 XKR9 LACTB2-AS1 TRAM1 H2AFZP2 BTF3P12
GH08G070665 1.4 Ensembl ENCODE 10.7 -59.6 -59576 5.2 HNRNPUL1 FOXA2 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 XKR9 LACTB2-AS1 TRAM1 LACTB2 RN7SL19P
GH08G070606 1.7 FANTOM5 Ensembl ENCODE 6.8 -0.3 -307 5.5 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZBTB7B YY1 XKR9 LACTB2 TRAM1 LACTB2-AS1 RN7SL19P
GH08G070641 0.7 ENCODE 11.4 -33.6 -33557 1.3 MXI1 MTA2 L3MBTL2 RNF2 CBX2 BMI1 CBX8 NBN POU5F1 TRIM28 XKR9 TRAM1 LACTB2-AS1 LACTB2 RN7SL19P
GH08G070631 0.7 ENCODE 11 -23.1 -23112 0.6 ELF3 SOX13 DRAP1 FOXA2 ZNF792 SAP130 ARID4B CEBPG DMAP1 ZNF644 XKR9 LACTB2-AS1 TRAM1 RN7SL19P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAM1 on UCSC Golden Path with GeneCards custom track

Promoters for TRAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225747 759 2201 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZBTB7B YY1

Genomic Location for TRAM1 Gene

Chromosome:
8
Start:
70,573,218 bp from pter
End:
70,608,459 bp from pter
Size:
35,242 bases
Orientation:
Minus strand

Genomic View for TRAM1 Gene

Genes around TRAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1 Gene

Proteins for TRAM1 Gene

  • Protein details for TRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15629-TRAM1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1
    Protein Accession:
    Q15629
    Secondary Accessions:
    • B4E0K2

    Protein attributes for TRAM1 Gene

    Size:
    374 amino acids
    Molecular mass:
    43072 Da
    Quaternary structure:
    • Interacts with human cytomegalovirus/HHV-5 protein US2.

    Alternative splice isoforms for TRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAM1 Gene

Post-translational modifications for TRAM1 Gene

  • Ubiquitination at isoforms=2283
  • Glycosylation at isoforms=256
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAM1 Gene

No data available for DME Specific Peptides for TRAM1 Gene

Domains & Families for TRAM1 Gene

Gene Families for TRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15629

UniProtKB/Swiss-Prot:

TRAM1_HUMAN :
  • Belongs to the TRAM family.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1: view

Function for TRAM1 Gene

Molecular function for TRAM1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane.

Gene Ontology (GO) - Molecular Function for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 1315422
GO:0005515 protein binding IPI 18555783
genes like me logo Genes that share ontologies with TRAM1: view
genes like me logo Genes that share phenotypes with TRAM1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1 Gene

Localization for TRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAM1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 18555783
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAM1: view

Pathways & Interactions for TRAM1 Gene

genes like me logo Genes that share pathways with TRAM1: view

Pathways by source for TRAM1 Gene

1 Sino Biological pathway for TRAM1 Gene
1 BioSystems pathway for TRAM1 Gene

Gene Ontology (GO) - Biological Process for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 1315422
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TRAM1: view

No data available for SIGNOR curated interactions for TRAM1 Gene

Drugs & Compounds for TRAM1 Gene

No Compound Related Data Available

Transcripts for TRAM1 Gene

Unigene Clusters for TRAM1 Gene

Translocation associated membrane protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for TRAM1 Gene

GeneLoc Exon Structure for
TRAM1
ECgene alternative splicing isoforms for
TRAM1

Expression for TRAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1 Gene

This gene is overexpressed in Nasal epithelium (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAM1 Gene



Protein tissue co-expression partners for TRAM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAM1 Gene:

TRAM1

SOURCE GeneReport for Unigene cluster for TRAM1 Gene:

Hs.491988

Evidence on tissue expression from TISSUES for TRAM1 Gene

  • Kidney(4.6)
  • Nervous system(4.6)
  • Lung(2.7)
  • Liver(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with TRAM1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAM1 Gene

Orthologs for TRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAM1 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia TRAM1 34 35
  • 94.03 (n)
cow
(Bos Taurus)
Mammalia TRAM1 34 35
  • 93.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tram1 34
  • 87.52 (n)
mouse
(Mus musculus)
Mammalia Tram1 34 16 35
  • 87.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAM1 34 35
  • 80.57 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tram1 34
  • 75.25 (n)
Str.6518 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20545 34
zebrafish
(Danio rerio)
Actinopterygii tram1 34 35
  • 69.56 (n)
tram 34
fruit fly
(Drosophila melanogaster)
Insecta TRAM 35
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 34 35
  • 50.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToMany
Species where no ortholog for TRAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAM1 Gene

ENSEMBL:
Gene Tree for TRAM1 (if available)
TreeFam:
Gene Tree for TRAM1 (if available)

Paralogs for TRAM1 Gene

Paralogs for TRAM1 Gene

(2) SIMAP similar genes for TRAM1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRAM1: view

Variants for TRAM1 Gene

Sequence variations from dbSNP and Humsavar for TRAM1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000038123 -- 70,575,411(+) TTCTT(-/TTTA)TTTAT intron-variant
rs1000046525 -- 70,578,067(+) GGGCC(A/G)GTAGC intron-variant
rs1000153662 -- 70,606,288(+) CCTGG(A/G)CTCAA intron-variant
rs1000166349 -- 70,597,983(+) TTGTT(C/T)TGGAG reference, missense
rs1000224668 -- 70,604,612(+) GTTCT(C/G)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAM1 Gene

Variant ID Type Subtype PubMed ID
nsv1068714 OTHER inversion 25765185

Variation tolerance for TRAM1 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1 Gene

Disorders for TRAM1 Gene

Relevant External Links for TRAM1

Genetic Association Database (GAD)
TRAM1
Human Genome Epidemiology (HuGE) Navigator
TRAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAM1

No disorders were found for TRAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAM1 Gene

Publications for TRAM1 Gene

  1. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. (PMID: 19121997) Oresic K. … Tortorella D. (J. Biol. Chem. 2009) 3 4 22 64
  2. A protein of the endoplasmic reticulum involved early in polypeptide translocation. (PMID: 1315422) Goerlich D. … Rapoport T.A. (Nature 1992) 2 3 4 64
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64

Products for TRAM1 Gene

Sources for TRAM1 Gene

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