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Aliases for TRAM1 Gene

Aliases for TRAM1 Gene

  • Translocation Associated Membrane Protein 1 2 3
  • TRAM 3 4
  • Translocating Chain-Associating Membrane Protein 3
  • Translocation-Associating Membrane Protein 1 3
  • PNAS8 3
  • TRAMP 3

External Ids for TRAM1 Gene

Previous GeneCards Identifiers for TRAM1 Gene

  • GC08M071426
  • GC08M071208
  • GC08M071535
  • GC08M071648
  • GC08M066978

Summaries for TRAM1 Gene

Entrez Gene Summary for TRAM1 Gene

  • This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRAM1 Gene

TRAM1 (Translocation Associated Membrane Protein 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gene Expression. GO annotations related to this gene include receptor activity. An important paralog of this gene is TRAM2.

UniProtKB/Swiss-Prot for TRAM1 Gene

  • Stimulatory or required for the translocation of secretory proteins across the ER membrane

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM1 Gene

Genomics for TRAM1 Gene

Regulatory Elements for TRAM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAM1 Gene

Chromosome:
8
Start:
70,573,218 bp from pter
End:
70,608,459 bp from pter
Size:
35,242 bases
Orientation:
Minus strand

Genomic View for TRAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM1 Gene

Proteins for TRAM1 Gene

  • Protein details for TRAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15629-TRAM1_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 1
    Protein Accession:
    Q15629
    Secondary Accessions:
    • B4E0K2

    Protein attributes for TRAM1 Gene

    Size:
    374 amino acids
    Molecular mass:
    43072 Da
    Quaternary structure:
    • Interacts with human cytomegalovirus/HHV-5 protein US2.

    Alternative splice isoforms for TRAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAM1 Gene

Proteomics data for TRAM1 Gene at MOPED

Post-translational modifications for TRAM1 Gene

Other Protein References for TRAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRAM1 Gene

Domains & Families for TRAM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15629

UniProtKB/Swiss-Prot:

TRAM1_HUMAN :
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TRAM family.
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM1: view

No data available for Gene Families for TRAM1 Gene

Function for TRAM1 Gene

Molecular function for TRAM1 Gene

UniProtKB/Swiss-Prot Function:
Stimulatory or required for the translocation of secretory proteins across the ER membrane

Gene Ontology (GO) - Molecular Function for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 1315422
GO:0005515 protein binding IPI 18555783
genes like me logo Genes that share ontologies with TRAM1: view

Phenotypes for TRAM1 Gene

genes like me logo Genes that share phenotypes with TRAM1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAM1 Gene

Localization for TRAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAM1 Gene COMPARTMENTS Subcellular localization image for TRAM1 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 18555783
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAM1: view

Pathways & Interactions for TRAM1 Gene

genes like me logo Genes that share pathways with TRAM1: view

Pathways by source for TRAM1 Gene

Gene Ontology (GO) - Biological Process for TRAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 1315422
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TRAM1: view

No data available for SIGNOR curated interactions for TRAM1 Gene

Drugs & Compounds for TRAM1 Gene

No Compound Related Data Available

Transcripts for TRAM1 Gene

Unigene Clusters for TRAM1 Gene

Translocation associated membrane protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for TRAM1 Gene

GeneLoc Exon Structure for
TRAM1
ECgene alternative splicing isoforms for
TRAM1

Expression for TRAM1 Gene

mRNA expression in normal human tissues for TRAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAM1 Gene

This gene is overexpressed in Nasal epithelium (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TRAM1 Gene



SOURCE GeneReport for Unigene cluster for TRAM1 Gene Hs.491988

genes like me logo Genes that share expression patterns with TRAM1: view

Protein tissue co-expression partners for TRAM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAM1 Gene

Orthologs for TRAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAM1 35
  • 93.58 (n)
  • 95.45 (a)
TRAM1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAM1 35
  • 94.03 (n)
  • 95.45 (a)
TRAM1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tram1 35
  • 87.34 (n)
  • 93.05 (a)
Tram1 16
Tram1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAM1 35
  • 99.47 (n)
  • 99.73 (a)
TRAM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tram1 35
  • 87.52 (n)
  • 93.58 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRAM1 35
  • 80.57 (n)
  • 83.69 (a)
TRAM1 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6518 35
tram1 35
  • 75.25 (n)
  • 80.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20545 35
zebrafish
(Danio rerio)
Actinopterygii tram 35
tram1 35
  • 69.56 (n)
  • 73.17 (a)
tram1 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta TRAM 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 35
  • 50.34 (n)
  • 40.76 (a)
tram-1 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TRAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAM1 Gene

ENSEMBL:
Gene Tree for TRAM1 (if available)
TreeFam:
Gene Tree for TRAM1 (if available)

Paralogs for TRAM1 Gene

Paralogs for TRAM1 Gene

(2) SIMAP similar genes for TRAM1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRAM1: view

Variants for TRAM1 Gene

Sequence variations from dbSNP and Humsavar for TRAM1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs8993 -- 70,573,850(+) TGTAG(A/C/T)GATAC utr-variant-3-prime
rs166537 -- 70,573,408(+) CCTAA(A/T)CACCA utr-variant-3-prime, downstream-variant-500B
rs182080 -- 70,576,031(+) gcgcc(A/C)ctgca intron-variant
rs183851 -- 70,575,931(+) aatta(A/G)ctggt intron-variant
rs185591 -- 70,576,303(+) atcca(A/G)aaaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAM1 Gene

Variant ID Type Subtype PubMed ID
dgv7805n71 CNV Gain 21882294

Variation tolerance for TRAM1 Gene

Residual Variation Intolerance Score: 33.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAM1 Gene

HapMap Linkage Disequilibrium report
TRAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM1 Gene

Disorders for TRAM1 Gene

Relevant External Links for TRAM1

Genetic Association Database (GAD)
TRAM1
Human Genome Epidemiology (HuGE) Navigator
TRAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAM1
genes like me logo Genes that share disorders with TRAM1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAM1 Gene

Publications for TRAM1 Gene

  1. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. (PMID: 19121997) Oresic K. … Tortorella D. (J. Biol. Chem. 2009) 23 67
  2. Sec61alpha and TRAM are sequentially adjacent to a nascent viral membrane protein during its ER integration. (PMID: 17169373) SaurA- A. … Mingarro I. (J. Mol. Biol. 2007) 23 67
  3. Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane. (PMID: 15306686) Saksena S. … Johnson A.E. (Proc. Natl. Acad. Sci. U.S.A. 2004) 23 67
  4. Protein disulphide isomerase and a lumenal cyclophilin-type peptidyl prolyl cis-trans isomerase are in transient contact with secretory proteins during late stages of translocation. (PMID: 7588713) Klappa P. … Zimmermann R. (Eur. J. Biochem. 1995) 23 67
  5. Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence. (PMID: 8253810) High S. … Dobberstein B. (J. Biol. Chem. 1993) 23 67

Products for TRAM1 Gene

Sources for TRAM1 Gene

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