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TRAM1 Gene

protein-coding   GIFtS: 61
GCID: GC08M071535

Translocation Associated Membrane Protein 1

  Search for TRAM1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Translocation Associated Membrane Protein 11 2     Translocating Chain-Associated Membrane Protein 12
TRAM2 3 5     Translocating Chain-Associating Membrane Protein2
PNAS82     Translocation-Associating Membrane Protein 12
TRAMP2     

External Ids:    HGNC: 205681   Entrez Gene: 234712   Ensembl: ENSG000000671677   OMIM: 6051905   UniProtKB: Q156293   

Export aliases for TRAM1 gene to outside databases

Previous GC identifers: GC08M071426 GC08M071208 GC08M071648 GC08M066978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAM1 Gene:
This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded
protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic
reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during
a translocational pause. (provided by RefSeq, Oct 2009)

GeneCards Summary for TRAM1 Gene:
TRAM1 (translocation associated membrane protein 1) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is TRAM1L1.

UniProtKB/Swiss-Prot: TRAM1_HUMAN, Q15629
Function: Stimulatory or required for the translocation of secretory proteins across the ER membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAM1 gene promoter:
         HOXA9   HOXA9B   AREB6   S8   HOXA3   FOXO4   Lmo2   Pax-4a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAM1 promoter sequence
   Search Chromatin IP Primers for TRAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.3   Ensembl cytogenetic band:  8q13.3   HGNC cytogenetic band: 8q13.1

TRAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAM1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M071535:  view genomic region     (about GC identifiers)

Start:
71,485,453 bp from pter      End:
71,520,694 bp from pter
Size:
35,242 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRAM1_HUMAN, Q15629 (See protein sequence)
Recommended Name: Translocating chain-associated membrane protein 1  
Size: 374 amino acids; 43072 Da
Subunit: Interacts with human cytomegalovirus/HHV-5 protein US2

Explore the universe of human proteins at neXtProt for TRAM1: NX_Q15629

Explore proteomics data for TRAM1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys283
  • Glycosylation2 at Asn56
  • Modification sites at PhosphoSitePlus

  • See TRAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055109.1  
    ENSEMBL proteins: 
     ENSP00000428052   ENSP00000262213   ENSP00000428025   ENSP00000439359  
    Reactome Protein details: Q15629

    TRAM1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TRAM1
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    Novus Biologicals TRAM1 Protein
    Novus Biologicals TRAM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAM1

     
    Search eBioscience for Proteins for TRAM1 

    TRAM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAM1
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    TRAM1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TRAM1
    Cloud-Clone Corp. CLIAs for TRAM1
    Search eBioscience for ELISAs for TRAM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016447 Translocation_assoc_membrane
     IPR013599 TRAM1
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q15629

    ProtoNet protein and cluster: Q15629

    3 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM
    IPB013599 TRAM1-like protein


    UniProtKB/Swiss-Prot: TRAM1_HUMAN, Q15629
    Similarity: Belongs to the TRAM family
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    Find genes that share domains with TRAM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAM1_HUMAN, Q15629
    Function: Stimulatory or required for the translocation of secretory proteins across the ER membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS1315422
    GO:0005515protein binding IPI18555783
         
    Find genes that share ontologies with TRAM1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRAM1:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRAM1:
    hsa-mir-155-5p (MIRT001493), hsa-mir-93-5p (MIRT048770), hsa-mir-26b-5p (MIRT028950)

    Block miRNA regulation of human, mouse, rat TRAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAM1 (see all 15):
    hsa-miR-4307 hsa-miR-187* hsa-miR-15a hsa-miR-218-1* hsa-miR-548v hsa-miR-497 hsa-miR-181a-2* hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidTRAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAM1
    Predesigned siRNA for gene silencing in human, mouse, rat TRAM1

    Gene Editing
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    OriGene ORF clones in mouse, rat for TRAM1
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    GenScript: all cDNA clones in your preferred vector: TRAM1 (NM_014294)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAM1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRAM1_HUMAN, Q15629: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS1315422
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TRAM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRAM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with TRAM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRAM1
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for TRAM1):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRAM1
    Interactions:

        Search GeneGlobe Interaction Network for TRAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAM1 (Q156291, 3 ENSP000002622134) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329693, ENSP000003460224I2D: score=5 STRING: ENSP00000346022
    RPL9P7P329693I2D: score=5 
    RPL9P8P329693I2D: score=5 
    RPL9P9P329693I2D: score=5 
    BCAP31P515721, 3, ENSP000003923304EBI-1788852,EBI-77683 I2D: score=1 STRING: ENSP00000392330
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS1315422
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0016032viral process IEA--

    Find genes that share ontologies with TRAM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRAM1 gene: 
    NM_014294.5  

    Unigene Cluster for TRAM1:

    Translocation associated membrane protein 1
    Hs.491988  [show with all ESTs]
    Unigene Representative Sequence: BC032018
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521425 ENST00000262213(uc011lfc.2 uc003xyo.2) ENST00000521049
    ENST00000520700 ENST00000518678 ENST00000536748
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAM1 (see all 15):
    hsa-miR-4307 hsa-miR-187* hsa-miR-15a hsa-miR-218-1* hsa-miR-548v hsa-miR-497 hsa-miR-181a-2* hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidTRAM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRAM1
    Predesigned siRNA for gene silencing in human, mouse, rat TRAM1
    Clone
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    OriGene clones in human, mouse for TRAM1 (see all 6)
    OriGene ORF clones in mouse, rat for TRAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAM1 (NM_014294)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAM1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRAM1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAM1
      QuantiTect SYBR Green Assays in human, mouse, rat TRAM1
      QuantiFast Probe-based Assays in human, mouse, rat TRAM1

    Additional mRNA sequence: 

    AF130055.2 AF274933.1 AK289397.1 AK292777.1 AK303411.1 BC000687.2 BC020283.1 BC032018.1 
    BC037738.1 BT007359.1 CR541654.1 CR541739.1 X63679.1 

    13 DOTS entries:

    DT.218609  DT.95141399  DT.100846268  DT.101984582  DT.121470766  DT.92450963  DT.87046040  DT.100846269 
    DT.40106518  DT.85104271  DT.40291068  DT.91950057  DT.99985880 

    Selected AceView cDNA sequences (see all 488):

    BM749257 BC000687 AI991359 BF901474 AU132871 BQ022521 AA393919 CR608813 
    AA687662 BM757702 CR541739 BI492372 BM758957 BM799776 AW470653 AL602739 
    AA424739 CA308157 BQ898098 BM758248 CN484936 BM769518 BU146257 BM053013 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRAM1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                     
    SP2:                                                                                    
    SP3:              -                                                                     
    SP4:              -           -                                                         


    ECgene alternative splicing isoforms for TRAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTAGGAA
    TRAM1 Expression
    About this image


    TRAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    TRAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491988
        Custom PCR Arrays for TRAM1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRAM1
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    QuantiFast Probe-based Assays in human, mouse, rat TRAM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRAM1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tram11 , 5 translocating chain-associating membrane protein 11, 5 87.34(n)1
    93.05(a)1
      1 (4.18 cM)5
    722651  NM_028173.41  NP_082449.11 
     135647025 
    chicken
    (Gallus gallus)
    Aves TRAM11 translocation associated membrane protein 1 80.57(n)
    83.69(a)
      378918  NM_204400.2  NP_989731.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    85(a)
    1 → many
    4(32375467-32408969)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.205452 Xenopus laevis transcribed sequence with moderate similarity more 77.16(n)    BU914571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tram2 translocating chain-associating membrane protein 76.43(n)   266757  BC063238.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta TRAM6
    TRAM
    38(a)
    1 → many
    X(829265-831855)
    worm
    (Caenorhabditis elegans)
    Secernentea tram-11 tram-1 50.34(n)
    40.76(a)
      177902  NM_069468.3  NP_501869.1 


    ENSEMBL Gene Tree for TRAM1 (if available)
    TreeFam Gene Tree for TRAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAM1 gene
    TRAM1L12  TRAM22  
    2 SIMAP similar genes for TRAM1 using alignment to 6 protein entries:     TRAM1_HUMAN (see all proteins):
    TRAM1L1    TRAM2

    Find genes that share paralogs with TRAM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAM1 (see all 704)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1147458461,2
    C,F--71484993(+) CAGAGT/GAGCAA 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1497048091,2
    --71485000(+) GCAAAA/GCAACT 1 -- ds50010--------
    rs1887180561,2
    --71485004(+) AGCAAC/TTAATT 1 -- ds50010--------
    rs1444835021,2
    --71485078(+) TCCCAC/TCATGC 1 -- ds50010--------
    rs1932944711,2
    C--71485245(+) TGGTAA/GTGACA 1 -- ds50010--------
    rs348976181,2
    C--71485260(+) TTTTTT/-CTTTG 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs2007309511,2
    C--71485271(-) GCAAAA/GAAAAA 1 -- ds50010--------
    rs20351961,2
    C,F,H--71485350(+) AAATAA/CGGTGG 1 -- ds500127Minor allele frequency- C:0.20NS EA NA MN WA 2886
    rs1847164421,2
    --71485449(+) ACCTTG/TAGGTT 1 -- ds50010--------
    rs785768481,2
    C,F--71485482(+) ATTTAT/CTTGGT 1 -- ut311Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for TRAM1 (71485453 - 71520694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7805n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605190    OMIM disorders: --


    Find genes that share disorders with TRAM1           About GenesLikeMe

    Genetic Association Database (GAD): TRAM1
    Human Genome Epidemiology (HuGE) Navigator: TRAM1 (6 documents)

    Export disorders for TRAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAM1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with TRAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A protein of the endoplasmic reticulum involved early in polypeptide translocation. (PubMed id 1315422)1, 2, 3 Goerlich D.... Rapoport T.A. (Nature 1992)
    2. TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. (PubMed id 19121997)1, 2, 9 Oresic K.... Tortorella D. (J. Biol. Chem. 2009)
    3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. (PubMed id 23247143)1 Yu B....Boerwinkle E. (Circ Cardiovasc Genet 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23471 HGNC: 20568 AceView: TRAM1 Ensembl:ENSG00000067167 euGenes: HUgn23471
    ECgene: TRAM1 Kegg: 23471 H-InvDB: TRAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRAM1 gene:
    Search GeneIP for patents involving TRAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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