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Aliases for TRAK2 Gene

Aliases for TRAK2 Gene

  • Trafficking Protein, Kinesin Binding 2 2 3
  • ALS2CR3 3 4 6
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 3 2 3
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 98 2 3
  • Gamma-Aminobutyric Acid(A) Receptor-Interacting Factor 2 3
  • KIAA0549 4 6
  • GRIF1 3 6
  • OIP98 3 6
  • Trafficking Kinesin-Binding Protein 2 3
  • Milton Homolog 2 (Drosophila) 2
  • Milton Homolog 2 3
  • CALS-C 3
  • GRIF-1 3
  • MILT2 3

External Ids for TRAK2 Gene

Previous HGNC Symbols for TRAK2 Gene

  • ALS2CR3

Previous GeneCards Identifiers for TRAK2 Gene

  • GC02M202068
  • GC02M201950
  • GC02M202241
  • GC02M194090

Summaries for TRAK2 Gene

GeneCards Summary for TRAK2 Gene

TRAK2 (Trafficking Protein, Kinesin Binding 2) is a Protein Coding gene. Diseases associated with TRAK2 include lateral sclerosis. Among its related pathways are Metabolism and Circadian entrainment. GO annotations related to this gene include receptor binding and GABA receptor binding. An important paralog of this gene is HAP1.

UniProtKB/Swiss-Prot for TRAK2 Gene

  • May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Gene Wiki entry for TRAK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK2 Gene

Genomics for TRAK2 Gene

Regulatory Elements for TRAK2 Gene

Genomic Location for TRAK2 Gene

Start:
201,377,207 bp from pter
End:
201,451,611 bp from pter
Size:
74,405 bases
Orientation:
Minus strand

Genomic View for TRAK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK2 Gene

Proteins for TRAK2 Gene

  • Protein details for TRAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60296-TRAK2_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 2
    Protein Accession:
    O60296
    Secondary Accessions:
    • E7EV21
    • Q8WVH7
    • Q96NS2
    • Q9C0K5
    • Q9C0K6

    Protein attributes for TRAK2 Gene

    Size:
    914 amino acids
    Molecular mass:
    101419 Da
    Quaternary structure:
    • Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS (By similarity). Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

    Alternative splice isoforms for TRAK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK2 Gene

Proteomics data for TRAK2 Gene at MOPED

Post-translational modifications for TRAK2 Gene

Other Protein References for TRAK2 Gene

No data available for DME Specific Peptides for TRAK2 Gene

Domains for TRAK2 Gene

Protein Domains for TRAK2 Gene

Suggested Antigen Peptide Sequences for TRAK2 Gene

Graphical View of Domain Structure for InterPro Entry

O60296

UniProtKB/Swiss-Prot:

TRAK2_HUMAN :
  • O60296
Domain:
  • Contains 1 HAP1 N-terminal domain.
genes like me logo Genes that share domains with TRAK2: view

No data available for Gene Families for TRAK2 Gene

Function for TRAK2 Gene

Molecular function for TRAK2 Gene

UniProtKB/Swiss-Prot Function: May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Gene Ontology (GO) - Molecular Function for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS 12034717
GO:0005515 protein binding IPI 15644324
GO:0019899 enzyme binding IEA --
GO:0050811 GABA receptor binding NAS 15644324
genes like me logo Genes that share ontologies with TRAK2: view

miRNA for TRAK2 Gene

miRTarBase miRNAs that target TRAK2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAK2 Gene

Localization for TRAK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK2 Gene

Cytoplasm. Early endosome. Mitochondrion. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAK2 Gene COMPARTMENTS Subcellular localization image for TRAK2 gene
Compartment Confidence
mitochondrion 4
plasma membrane 4
cytosol 3
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0005768 endosome --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with TRAK2: view

Pathways for TRAK2 Gene

SuperPathways for TRAK2 Gene

Superpath Contained pathways
1 Metabolism
2 Circadian entrainment
genes like me logo Genes that share pathways with TRAK2: view

Pathways by source for TRAK2 Gene

2 KEGG pathways for TRAK2 Gene

Gene Ontology (GO) - Biological Process for TRAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006493 protein O-linked glycosylation IEA --
GO:0006605 protein targeting IEA --
genes like me logo Genes that share ontologies with TRAK2: view

Compounds for TRAK2 Gene

(2) Novoseek inferred chemical compound relationships for TRAK2 Gene

Compound -log(P) Hits PubMed IDs
n-acetylglucosamine 62.4 1
gaba 41.2 3
genes like me logo Genes that share compounds with TRAK2: view

Transcripts for TRAK2 Gene

Unigene Clusters for TRAK2 Gene

Trafficking protein, kinesin binding 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7:

ExUns: 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TRAK2 Gene

GeneLoc Exon Structure for
TRAK2
ECgene alternative splicing isoforms for
TRAK2

Expression for TRAK2 Gene

mRNA expression in normal human tissues for TRAK2 Gene

mRNA differential expression in normal tissues according to GTEx for TRAK2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRAK2 Gene

SOURCE GeneReport for Unigene cluster for TRAK2 Gene Hs.152774

mRNA Expression by UniProt/SwissProt for TRAK2 Gene

O60296-TRAK2_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart
genes like me logo Genes that share expressions with TRAK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRAK2 Gene

Orthologs for TRAK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAK2 35
  • 99.31 (n)
  • 99.23 (a)
TRAK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAK2 35
  • 89.77 (n)
  • 90.02 (a)
TRAK2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAK2 35
  • 91.23 (n)
  • 92.18 (a)
TRAK2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trak2 35
  • 85.45 (n)
  • 87.72 (a)
Trak2 16
Trak2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAK2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trak2 35
  • 84.98 (n)
  • 86.95 (a)
chicken
(Gallus gallus)
Aves TRAK2 35
  • 73.27 (n)
  • 74.92 (a)
TRAK2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAK2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trak2 35
  • 63.21 (n)
  • 61.8 (a)
zebrafish
(Danio rerio)
Actinopterygii trak2 35
  • 59.47 (n)
  • 60 (a)
trak2 36
  • 48 (a)
OneToOne
wufj21g01 35
fruit fly
(Drosophila melanogaster)
Insecta milt 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 36
  • 21 (a)
OneToMany
Species with no ortholog for TRAK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK2 Gene

ENSEMBL:
Gene Tree for TRAK2 (if available)
TreeFam:
Gene Tree for TRAK2 (if available)

Paralogs for TRAK2 Gene

Paralogs for TRAK2 Gene

Selected SIMAP similar genes for TRAK2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TRAK2 Gene

genes like me logo Genes that share paralogs with TRAK2: view

Variants for TRAK2 Gene

Sequence variations from dbSNP and Humsavar for TRAK2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2470 -- 201,380,083(+) CAGTA(A/T)TAGAC utr-variant-3-prime
rs7616 -- 201,377,584(-) TAAAG(C/G)GTATA utr-variant-3-prime
rs8105 -- 201,377,412(-) ATGCA(A/G)CCCAA utr-variant-3-prime
rs887995 -- 201,390,516(+) CTGAG(A/T)TCGCA intron-variant
rs917982 -- 201,408,385(+) AACTC(A/G/T)TGTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRAK2 Gene

Variant ID Type Subtype PubMed ID
nsv875708 CNV Gain 21882294
esv272558 CNV Insertion 20981092
esv267788 CNV Insertion 20981092
esv28629 CNV Loss 19812545
esv1007085 CNV Insertion 20482838

Relevant External Links for TRAK2 Gene

HapMap Linkage Disequilibrium report
TRAK2
Human Gene Mutation Database (HGMD)
TRAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK2 Gene

Disorders for TRAK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAK2 Gene including...

Search for TRAK2 Gene in MalaCards »

Relevant External Links for TRAK2

Genetic Association Database (GAD)
TRAK2
Human Genome Epidemiology (HuGE) Navigator
TRAK2
genes like me logo Genes that share disorders with TRAK2: view

No data available for UniProtKB/Swiss-Prot for TRAK2 Gene

Publications for TRAK2 Gene

  1. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PMID: 11161814) Hadano S. … Hayden M.R. (Genomics 2001) 2 3 4
  3. Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. (PMID: 12034717) Beck M. … Stephenson F.A. (J. Biol. Chem. 2002) 3 23
  4. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer S.P.N. … Hart G.W. (J. Biol. Chem. 2003) 3 23
  5. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K. … Stephenson F.A. (J. Biol. Chem. 2005) 3 23

Products for TRAK2 Gene

Sources for TRAK2 Gene

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