Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAK1 Gene

Aliases for TRAK1 Gene

  • Trafficking Protein, Kinesin Binding 1 2 3
  • OIP106 3 4 6
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 106 2 3
  • 106 KDa O-GlcNAc Transferase-Interacting Protein 3 4
  • KIAA1042 4 6
  • OGT(O Glc NAc Transferase) Interacting Protein 106 KDa 2
  • OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa 3
  • Trafficking Kinesin-Binding Protein 1 3
  • Milton Homolog 1 (Drosophila) 2
  • Milton Homolog 1 3
  • MILT1 3

External Ids for TRAK1 Gene

Summaries for TRAK1 Gene

GeneCards Summary for TRAK1 Gene

TRAK1 (Trafficking Protein, Kinesin Binding 1) is a Protein Coding gene. Diseases associated with TRAK1 include hypertonia. GO annotations related to this gene include GABA receptor binding. An important paralog of this gene is HAP1.

UniProtKB/Swiss-Prot for TRAK1 Gene

  • Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Wiki entry for TRAK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK1 Gene

Genomics for TRAK1 Gene

Genomic Location for TRAK1 Gene

Start:
42,013,802 bp from pter
End:
42,225,890 bp from pter
Size:
212,089 bases
Orientation:
Plus strand

Genomic View for TRAK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK1 Gene

Regulatory Elements for TRAK1 Gene

Proteins for TRAK1 Gene

  • Protein details for TRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPV9-TRAK1_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 1
    Protein Accession:
    Q9UPV9
    Secondary Accessions:
    • E9PDS2
    • J3KNT7
    • Q63HR0
    • Q659B5
    • Q96B69

    Protein attributes for TRAK1 Gene

    Size:
    953 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 (By similarity). Interacts with KIF5C.
    Miscellaneous:
    • Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer
    SequenceCaution:
    • Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK1 Gene

Proteomics data for TRAK1 Gene at MOPED

Post-translational modifications for TRAK1 Gene

No data available for DME Specific Peptides for TRAK1 Gene

Domains for TRAK1 Gene

Protein Domains for TRAK1 Gene

UniProtKB/Swiss-Prot:

TRAK1_HUMAN
Domain:
  • The C-terminal region is required for the early endosomal and mitochondrial localization:
    • Q9UPV9
  • Contains 1 HAP1 N-terminal domain.:
    • Q9UPV9
genes like me logo Genes that share domains with TRAK1: view

No data available for Gene Families for TRAK1 Gene

Function for TRAK1 Gene

Molecular function for TRAK1 Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Ontology (GO) - Molecular Function for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644324
GO:0050811 GABA receptor binding IEA --
genes like me logo Genes that share ontologies with TRAK1: view
genes like me logo Genes that share phenotypes with TRAK1: view

miRNA for TRAK1 Gene

miRTarBase miRNAs that target TRAK1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAK1 Gene

Localization for TRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK1 Gene

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAK1 Gene COMPARTMENTS Subcellular localization image for TRAK1 gene
Compartment Confidence
endosome 5
mitochondrion 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 19528298
GO:0005739 mitochondrion IDA 15644324
GO:0005769 early endosome IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

Pathways for TRAK1 Gene

SuperPathways for TRAK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0006493 protein O-linked glycosylation ISS --
GO:0006605 protein targeting ISS --
GO:0008333 endosome to lysosome transport IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

No data available for Pathways by source for TRAK1 Gene

Transcripts for TRAK1 Gene

Unigene Clusters for TRAK1 Gene

Trafficking protein, kinesin binding 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: -
SP7: - -
SP8:

ExUns: 17c ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for TRAK1 Gene

GeneLoc Exon Structure for
TRAK1
ECgene alternative splicing isoforms for
TRAK1

Expression for TRAK1 Gene

mRNA expression in normal human tissues for TRAK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAK1 Gene

SOURCE GeneReport for Unigene cluster for TRAK1 Gene Hs.535711

mRNA Expression by UniProt/SwissProt for TRAK1 Gene

Q9UPV9-TRAK1_HUMAN
Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.
genes like me logo Genes that share expressions with TRAK1: view

Orthologs for TRAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAK1 36
  • 99.55 (n)
  • 99.79 (a)
TRAK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 88 (a)
OneToMany
TRAK1 37
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRAK1 36
  • 91.82 (n)
  • 97.17 (a)
TRAK1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trak1 36
  • 88.45 (n)
  • 94.99 (a)
Trak1 16
Trak1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAK1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAK1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trak1 36
  • 88.17 (n)
  • 94.78 (a)
chicken
(Gallus gallus)
Aves TRAK1 36
  • 80.16 (n)
  • 89.83 (a)
TRAK1 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAK1 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3942 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14348 36
zebrafish
(Danio rerio)
Actinopterygii Dr.26160 36
trak1 37
  • 69 (a)
OneToMany
TRAK1 (2 of 3) 37
  • 48 (a)
OneToMany
TRAK1 (3 of 3) 37
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008801 36
  • 48.26 (n)
  • 39.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta milt 36
  • 47.72 (n)
  • 38.46 (a)
milt 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 37
  • 24 (a)
OneToMany
Species with no ortholog for TRAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK1 Gene

ENSEMBL:
Gene Tree for TRAK1 (if available)
TreeFam:
Gene Tree for TRAK1 (if available)

Paralogs for TRAK1 Gene

Paralogs for TRAK1 Gene

Selected SIMAP similar genes for TRAK1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAK1: view

Variants for TRAK1 Gene

Sequence variations from dbSNP and Humsavar for TRAK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1043621 -- 42,224,854(+) TCACC(A/G)TGCGG utr-variant-3-prime
rs1043610 -- 42,224,142(+) TGTCA(C/T)GCGGC utr-variant-3-prime
rs1010987 -- 42,176,603(+) GTTAC(C/G)AGTCC intron-variant
rs1002947 -- 42,048,752(+) agaga(C/T)ggggt intron-variant
rs1002534 -- 42,051,290(-) GATGA(C/G)ATCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK1 Gene

Variant ID Type Subtype PubMed ID
nsv460520 CNV Gain 19166990
esv32892 CNV Gain 17666407
nsv834671 CNV Gain 17160897

Relevant External Links for TRAK1 Gene

HapMap Linkage Disequilibrium report
TRAK1

Disorders for TRAK1 Gene

(1) MalaCards Diseases for TRAK1 Gene

Search for TRAK1 Gene in MalaCards »

Relevant External Links for TRAK1

Genetic Association Database (GAD)
TRAK1
Human Genome Epidemiology (HuGE) Navigator
TRAK1
genes like me logo Genes that share disorders with TRAK1: view

No data available for UniProtKB/Swiss-Prot for TRAK1 Gene

Publications for TRAK1 Gene

  1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer S.P.N. … Hart G.W. (J. Biol. Chem. 2003) 2 3 4 23
  2. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K. … Stephenson F.A. (J. Biol. Chem. 2005) 3 4 23
  3. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAK1 Gene

Sources for TRAK1 Gene

Back to Top

Content