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Aliases for TRAK1 Gene

Aliases for TRAK1 Gene

  • Trafficking Kinesin Protein 1 2 3 5
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 106 2 3
  • 106 KDa O-GlcNAc Transferase-Interacting Protein 3 4
  • Trafficking Protein, Kinesin Binding 1 2 3
  • OIP106 3 4
  • OGT(O Glc NAc Transferase) Interacting Protein 106 KDa 2
  • OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa 3
  • Trafficking Kinesin-Binding Protein 1 3
  • Milton Homolog 1 (Drosophila) 2
  • Milton Homolog 1 3
  • KIAA1042 4
  • MILT1 3

External Ids for TRAK1 Gene

Previous GeneCards Identifiers for TRAK1 Gene

  • GC03P042108

Summaries for TRAK1 Gene

GeneCards Summary for TRAK1 Gene

TRAK1 (Trafficking Kinesin Protein 1) is a Protein Coding gene. Among its related pathways are Oncogenic MAPK signaling and HIV Life Cycle. GO annotations related to this gene include GABA receptor binding. An important paralog of this gene is TRAK2.

UniProtKB/Swiss-Prot for TRAK1 Gene

  • Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Wiki entry for TRAK1 Gene

Additional gene information for TRAK1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK1 Gene

Genomics for TRAK1 Gene

Regulatory Elements for TRAK1 Gene

Enhancers for TRAK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H042057 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27 +49.7 49695 12 PKNOX1 FOXA2 SIN3A ATF7 RUNX3 DEK JUNB NFIL3 MAFF STAT3 TRAK1 ULK4 KRBOX1 ENSG00000229339 GC03P042123
GH03H042031 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.5 +21.1 21074 7 HDGF FOXA2 MLX ARID4B DMAP1 YY1 FOS SP5 MXD4 JUNB TRAK1 ULK4 SEC22C ZNF662 LINC02158 ENSG00000229339
GH03H042041 1.5 Ensembl ENCODE dbSUPER 21.5 +30.4 30401 5 HDGF FOXA2 TCF12 GLIS2 GATA2 FOS RUNX3 SP3 SP5 JUNB TRAK1 ULK4 VIPR1 ENSG00000229339
GH03H042098 1.4 Ensembl ENCODE dbSUPER 18 +85.6 85621 2 ELF3 HDGF RB1 ARNT ARID4B BRCA1 RAD21 RFX5 ZNF143 ATF7 TRAK1 ENSG00000212145 ULK4 CCK GC03P042123 ENSG00000229339
GH03H042100 1.3 Ensembl ENCODE dbSUPER 17.7 +88.4 88370 2 ELF3 SOX13 MXI1 FOXA2 SAP130 ARID4B MAX CEBPG RAD21 RARA TRAK1 ENSG00000212145 ULK4 CCK GC03P042123 ENSG00000229339
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAK1 on UCSC Golden Path with GeneCards custom track

Promoters for TRAK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000151299 398 2401 HDGF PKNOX1 ARNT SIN3A ARID4B YY1 ZNF766 ZNF143 ZNF207 ZNF548

Genomic Location for TRAK1 Gene

Chromosome:
3
Start:
42,013,802 bp from pter
End:
42,225,890 bp from pter
Size:
212,089 bases
Orientation:
Plus strand

Genomic View for TRAK1 Gene

Genes around TRAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK1 Gene

Proteins for TRAK1 Gene

  • Protein details for TRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPV9-TRAK1_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 1
    Protein Accession:
    Q9UPV9
    Secondary Accessions:
    • E9PDS2
    • J3KNT7
    • Q63HR0
    • Q659B5
    • Q96B69

    Protein attributes for TRAK1 Gene

    Size:
    953 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 (By similarity). Interacts with KIF5C.
    Miscellaneous:
    • Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.
    SequenceCaution:
    • Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK1 Gene

Post-translational modifications for TRAK1 Gene

No data available for DME Specific Peptides for TRAK1 Gene

Domains & Families for TRAK1 Gene

Gene Families for TRAK1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRAK1 Gene

Suggested Antigen Peptide Sequences for TRAK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPV9

UniProtKB/Swiss-Prot:

TRAK1_HUMAN :
  • The C-terminal region is required for the early endosomal and mitochondrial localization.
Domain:
  • The C-terminal region is required for the early endosomal and mitochondrial localization.
genes like me logo Genes that share domains with TRAK1: view

Function for TRAK1 Gene

Molecular function for TRAK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Phenotypes From GWAS Catalog for TRAK1 Gene

Gene Ontology (GO) - Molecular Function for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644324
GO:0030911 TPR domain binding IEA --
GO:0050811 GABA receptor binding IEA --
genes like me logo Genes that share ontologies with TRAK1: view
genes like me logo Genes that share phenotypes with TRAK1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRAK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAK1 Gene

Localization for TRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK1 Gene

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAK1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endosome 5
cytosol 3
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA,IEA 19528298
GO:0005739 mitochondrion IDA,IEA 15644324
GO:0005768 endosome IEA --
GO:0005769 early endosome IDA,IEA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

Pathways & Interactions for TRAK1 Gene

genes like me logo Genes that share pathways with TRAK1: view

Pathways by source for TRAK1 Gene

Gene Ontology (GO) - Biological Process for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0006493 protein O-linked glycosylation ISS --
GO:0006605 protein targeting ISS --
GO:0008333 endosome to lysosome transport IDA 18675823
GO:0048813 dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with TRAK1: view

No data available for SIGNOR curated interactions for TRAK1 Gene

Drugs & Compounds for TRAK1 Gene

No Compound Related Data Available

Transcripts for TRAK1 Gene

Unigene Clusters for TRAK1 Gene

Trafficking protein, kinesin binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRAK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: -
SP7: - -
SP8:

ExUns: 17c ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for TRAK1 Gene

GeneLoc Exon Structure for
TRAK1
ECgene alternative splicing isoforms for
TRAK1

Expression for TRAK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAK1 Gene

Protein differential expression in normal tissues from HIPED for TRAK1 Gene

This gene is overexpressed in Cervix (41.6), Heart (17.7), and Adipocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAK1 Gene



Protein tissue co-expression partners for TRAK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAK1 Gene:

TRAK1

SOURCE GeneReport for Unigene cluster for TRAK1 Gene:

Hs.535711

mRNA Expression by UniProt/SwissProt for TRAK1 Gene:

Q9UPV9-TRAK1_HUMAN
Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.

Evidence on tissue expression from TISSUES for TRAK1 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Lung(2.5)
  • Eye(2.3)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TRAK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAK1 Gene

Orthologs for TRAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAK1 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia TRAK1 33 34
  • 91.82 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAK1 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAK1 34
  • 89 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trak1 33 16 34
  • 88.45 (n)
rat
(Rattus norvegicus)
Mammalia Trak1 33
  • 88.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRAK1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAK1 33 34
  • 80.16 (n)
lizard
(Anolis carolinensis)
Reptilia TRAK1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14348 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3942 33
zebrafish
(Danio rerio)
Actinopterygii trak1 34
  • 69 (a)
OneToMany
TRAK1 (2 of 3) 34
  • 48 (a)
OneToMany
TRAK1 (3 of 3) 34
  • 36 (a)
OneToMany
Dr.26160 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008801 33
  • 48.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta milt 33 34
  • 47.72 (n)
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 34
  • 24 (a)
OneToMany
Species where no ortholog for TRAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK1 Gene

ENSEMBL:
Gene Tree for TRAK1 (if available)
TreeFam:
Gene Tree for TRAK1 (if available)

Paralogs for TRAK1 Gene

Paralogs for TRAK1 Gene

(3) SIMAP similar genes for TRAK1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAK1: view

Variants for TRAK1 Gene

Sequence variations from dbSNP and Humsavar for TRAK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000040194 -- 42,095,275(+) TTCAC(A/G)TTTGA intron-variant
rs1000078637 -- 42,217,663(+) TCTTT(C/T)AAATG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000080025 -- 42,131,091(+) GCAGG(C/G)CTCAT intron-variant
rs1000084083 -- 42,090,457(+) GAGGC(A/G)GGCAG intron-variant, upstream-variant-2KB
rs1000092073 -- 42,095,499(+) AGAGC(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK1 Gene

Variant ID Type Subtype PubMed ID
dgv8295n54 CNV gain 21841781
esv2760776 CNV gain 21179565
esv32892 CNV gain 17666407
esv3595984 CNV gain 21293372
nsv1127953 CNV deletion 24896259
nsv460520 CNV gain 19166990
nsv834671 CNV gain 17160897

Variation tolerance for TRAK1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK1 Gene

Disorders for TRAK1 Gene

Relevant External Links for TRAK1

Genetic Association Database (GAD)
TRAK1
Human Genome Epidemiology (HuGE) Navigator
TRAK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAK1

No disorders were found for TRAK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAK1 Gene

Publications for TRAK1 Gene

  1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer SP … Hart GW (The Journal of biological chemistry 2003) 2 3 4 22 60
  2. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S … Aspenström P (Biochemical and biophysical research communications 2006) 3 4 22 60
  3. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K … Stephenson FA (The Journal of biological chemistry 2005) 3 4 22 60
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for TRAK1 Gene

Sources for TRAK1 Gene

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