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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAK1 Gene

protein-coding   GIFtS: 55
GCID: GC03P042108

Trafficking Protein, Kinesin Binding 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Trafficking Protein, Kinesin Binding 11 2     OGT(O Glc NAc Transferase) Interacting Protein 106 KDa1
OIP1062 3 5     MILT12
O-Linked N-Acetylglucosamine Transferase Interacting Protein 1061 2     Milton Homolog 12
106 KDa O-GlcNAc Transferase-Interacting Protein2 3     OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa2
KIAA10423 5     Trafficking Kinesin-Binding Protein 12
Milton Homolog 1 (Drosophila)1     

External Ids:    HGNC: 299471   Entrez Gene: 229062   Ensembl: ENSG000001826067   OMIM: 6081125   UniProtKB: Q9UPV93   

Export aliases for TRAK1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRAK1 Gene: 
TRAK1 (trafficking protein, kinesin binding 1) is a protein-coding gene. Diseases associated with TRAK1 include hypertonia, and cerebral palsy. GO annotations related to this gene include protein binding and GABA receptor binding. An important paralog of this gene is TRAK2.

UniProtKB/Swiss-Prot: TRAK1_HUMAN, Q9UPV9
Function: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of
EGF-EGFR complexes and GABA-A receptors

Gene Wiki entry for TRAK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAK1 gene promoter:
         USF1   AML1a   ATF-2   Nkx2-5   CUTL1   LCR-F1   E2F-1   E2F   USF-1   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

TRAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAK1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042108:  view genomic region     (about GC identifiers)

Start:
42,055,294 bp from pter      End:
42,267,381 bp from pter
Size:
212,088 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAK1_HUMAN, Q9UPV9 (See protein sequence)
Recommended Name: Trafficking kinesin-binding protein 1  
Size: 953 amino acids; 106040 Da
Subunit: Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS.
Interacts with GABRA1 (By similarity). Interacts with KIF5C
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated
with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with
MGARP at the mitochondria
Miscellaneous: Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring
carcinoma and may serve as a marker of gastric cancer
Sequence caution: Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: E9PDS2 Q63HR0 Q659B5 Q96B69
Alternative splicing: 3 isoforms:  Q9UPV9-1   Q9UPV9-2   Q9UPV9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAK1: NX_Q9UPV9

Explore proteomics data for TRAK1 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPV9

  • TRAK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAK1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001036111.1  NP_001252537.1  NP_001252538.1  NP_001252539.1  NP_055780.2  

    ENSEMBL proteins: 
     ENSP00000328998   ENSP00000410717   ENSP00000409940   ENSP00000340702   ENSP00000379478  
     ENSP00000413729  

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    Cloud-Clone Corp. Proteins for TRAK1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA19528298
    GO:0005739mitochondrion IDA15644324
    GO:0005769early endosome IDA18675823

    TRAK1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022154 Traffickng_kinesin-bd_prot_dom
     IPR006933 HAP1_N

    Graphical View of Domain Structure for InterPro Entry Q9UPV9

    ProtoNet protein and cluster: Q9UPV9

    1 Blocks protein domain: IPB006933 HAP1

    UniProtKB/Swiss-Prot: TRAK1_HUMAN, Q9UPV9
    Domain: The C-terminal region is required for the early endosomal and mitochondrial localization
    Similarity: Contains 1 HAP1 N-terminal domain


    TRAK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAK1_HUMAN, Q9UPV9
    Function: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of
    EGF-EGFR complexes and GABA-A receptors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15644324
    GO:0050811GABA receptor binding IEA--
         
    TRAK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAK1:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trak1):
     behavior/neurological  mortality/aging  muscle  nervous system 

    TRAK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAK1 
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    SwitchGear 3'UTR luciferase reporter plasmidTRAK1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for TRAK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAK1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for TRAK1 (Q9UPV91, 2, 3 ENSP000003289984) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOT1Q8IXI21, 3, ENSP000003511324EBI-1105048,EBI-1396430 I2D: score=5 STRING: ENSP00000351132
    SKILP127572, 3MINT-61638 I2D: score=3 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    RHOT2Q8IXI13, ENSP000003219714I2D: score=1 STRING: ENSP00000321971
    OGTO152943, ENSP000003628244I2D: score=3 STRING: ENSP00000362824
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006493protein O-linked glycosylation ISS--
    GO:0006605protein targeting ISS--
    GO:0008333endosome to lysosome transport IDA18675823

    TRAK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAK1

    Search CenterWatch for drugs/clinical trials and news about TRAK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAK1 gene (5 alternative transcripts): 
    NM_001042646.2  NM_001265608.1  NM_001265609.1  NM_001265610.1  NM_014965.4  

    Unigene Cluster for TRAK1:

    Trafficking protein, kinesin binding 1
    Hs.535711  [show with all ESTs]
    Unigene Representative Sequence: NM_001042646
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487159 ENST00000484786 ENST00000327628(uc003cky.3 uc011azi.2)
    ENST00000449246(uc003ckz.4) ENST00000418790 ENST00000341421(uc011azh.2 uc011azj.2 uc003cla.3)
    ENST00000396175 ENST00000469506 ENST00000427771
    miRNA
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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAK1 (see all 41):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-520f hsa-miR-15a hsa-miR-503 hsa-miR-502-3p hsa-miR-424 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidTRAK1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAK1
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    Additional mRNA sequence: 

    AB028965.1 AK000754.1 AK023962.1 AK294221.1 AK295480.1 AK295848.1 AK316260.1 AL713787.1 
    BC015922.1 BX647199.1 

    15 DOTS entries:

    DT.91704675  DT.118205  DT.100845141  DT.97857649  DT.120869149  DT.99927056  DT.100819026  DT.100819025 
    DT.120869198  DT.120869252  DT.423174  DT.91938881  DT.97811284  DT.40286676  DT.97816383 

    24/336 AceView cDNA sequences (see all 336):

    Z41254 AI274289 BQ214886 BF434023 AW470772 BM827882 BE677665 AW629968 
    BX499783 AA359049 AA037342 AW500574 CD245407 AA322692 AI383884 BE675398 
    T16631 AA806117 AA313243 BQ672189 BM922991 T28064 BG258268 AI879670 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
    SP1:              -     -     -     -     -                       -                                                                                             
    SP2:                                                              -                                                                                             
    SP3:                                                                                                  -                                                         
    SP4:                          -     -     -                       -                                                                                             
    SP5:                                                                                                                                                        -   

    ExUns: 17c ^ 18a · 18b ^ 19a · 19b
    SP1:  -                           
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:  -                           


    ECgene alternative splicing isoforms for TRAK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRAK1 Expression
    About this image


    See TRAK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAK1

    SOURCE GeneReport for Unigene cluster: Hs.535711

    UniProtKB/Swiss-Prot: TRAK1_HUMAN, Q9UPV9
    Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain
    regions examined. Expressed in all cell lines examined

        SABiosciences Custom PCR Arrays for TRAK1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAK1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trak11 , 5 trafficking protein, kinesin binding 11, 5 88.45(n)1
    94.99(a)1
      9 (72.41 cM)5
    670951  NM_175114.31  NP_780323.21 
     1213669585 
    chicken
    (Gallus gallus)
    Aves TRAK11 trafficking protein, kinesin binding 1 80.2(n)
    89.9(a)
      420714  XM_418813.2  XP_418813.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRAK16
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343224.1(1312802-1365502)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39422 Xenopus laevis transcribed sequence with moderate similarity to protein spQ9UPV9 (H.sapiens) YA42_HUMAN Hypothetical protein KIAA1042 less 76.28(n)    CB206980.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.261602 Transcribed sequence with strong similarity to protein spQ9UPV9 (H.sapiens) YA42_HUMAN Hypothetical protein KIAA1042 less 92.71(n)    CD581348.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta milt1 milton 47.41(n)
    37.39(a)
      45683  NM_080765.3  NP_542943.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T27A3.16
    Protein T27A3.1, isoform a
    22(a)
    1 → many
    I(6122590-6126854)


    ENSEMBL Gene Tree for TRAK1 (if available)
    TreeFam Gene Tree for TRAK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAK1 gene
    TRAK22  HAP12  
    3 SIMAP similar genes for TRAK1 using alignment to 5 protein entries:     TRAK1_HUMAN (see all proteins):
    DKFZp451C1616    ALS2CR3    TRAK2

    TRAK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3169 SNPs in TRAK1 are shown (see all 3169)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931195671,2
    --42130765(+) CCCAGC/TATTTA 2 -- us2k10--------
    rs1446132111,2
    C--42130808(+) ATGACC/G/TGCACT 2 -- us2k10--------
    rs767338231,2
    C,F--42130891(+) GGCTTT/CTAATA 2 -- us2k11Minor allele frequency- C:0.07NA 120
    rs65991981,2
    C,F,A--42130935(-) gggagC/Gtcact 2 -- us2k12Minor allele frequency- G:0.15CSA WA 120
    rs20884781,2
    C--42130995(-) TCAGCG/AGGGCA 2 -- us2k14Minor allele frequency- A:0.40WA NA EA 360
    rs1854890221,2
    --42130996(+) GCCCCA/GCTGAC 2 -- us2k10--------
    rs1466535481,2
    --42131001(+) GCTGAC/TCTGCC 2 -- us2k10--------
    rs730624571,2
    C--42131036(+) GTACAC/TTGGCC 2 -- us2k10--------
    rs1453971741,2
    --42131113(+) GATATC/GCTTAT 2 -- us2k10--------
    rs1894370721,2
    --42131140(+) TCCAAA/GTGACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRAK1 (42055294 - 42267381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRAK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv460520CNV Gain19166990
    nsv834671CNV Gain17160897
    esv32892CNV Gain17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608112    OMIM disorders: --

    9 diseases for TRAK1:    About MalaCards
    hypertonia    cerebral palsy    gastric adenocarcinoma    cerebritis
    schizophrenia    hypoxia    gastric cancer    adenocarcinoma
    colorectal cancer


    TRAK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRAK1
    Human Genome Epidemiology (HuGE) Navigator: TRAK1 (1 document)

    Export disorders for TRAK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAK1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with TRAK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PubMed id 12435728)1, 2, 3, 9 Iyer S.P.N.... Hart G.W. (2003)
    2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2, 3 Kikuno R....Ohara O. (1999)
    3. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PubMed id 15644324)1, 2, 9 Brickley K....Stephenson F.A. (2005)
    4. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)1, 2, 9 Fransson S.... Aspenstroem P. (2006)
    5. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. (PubMed id 20230862)1, 3 Koutsopoulos O.S....Ryan M.T. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker. (PubMed id 18986759)1, 2 Zhang F....Fan D. (2009)
    8. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, a lters mitochondrial distribution and transport. (PubMed id 19528298)1, 2 Li Y....Rempe D.A. (2009)
    9. Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking. (PubMed id 18675823)1, 2 Webber E....Chin L.S. (2008)
    10. Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice. (PubMed id 16380713)1, 3 Gilbert S.L....Lahn B.T. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22906 HGNC: 29947 AceView: OIP106 Ensembl:ENSG00000182606 euGenes: HUgn22906
    ECgene: TRAK1 H-InvDB: TRAK1

    (According to HUGE)
    About This Section
    HUGE: KIAA1042

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAK1 gene:
    Search GeneIP for patents involving TRAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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