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Aliases for TRAK1 Gene

Aliases for TRAK1 Gene

  • Trafficking Kinesin Protein 1 2 3 5
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 106 2 3
  • 106 KDa O-GlcNAc Transferase-Interacting Protein 3 4
  • Trafficking Protein, Kinesin Binding 1 2 3
  • OIP106 3 4
  • OGT(O Glc NAc Transferase) Interacting Protein 106 KDa 2
  • OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa 3
  • Trafficking Kinesin-Binding Protein 1 3
  • Milton Homolog 1 (Drosophila) 2
  • Milton Homolog 1 3
  • KIAA1042 4
  • MILT1 3

External Ids for TRAK1 Gene

Previous GeneCards Identifiers for TRAK1 Gene

  • GC03P042108

Summaries for TRAK1 Gene

GeneCards Summary for TRAK1 Gene

TRAK1 (Trafficking Kinesin Protein 1) is a Protein Coding gene. Diseases associated with TRAK1 include Hypertonia. GO annotations related to this gene include GABA receptor binding. An important paralog of this gene is TRAK2.

UniProtKB/Swiss-Prot for TRAK1 Gene

  • Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Wiki entry for TRAK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK1 Gene

Genomics for TRAK1 Gene

Regulatory Elements for TRAK1 Gene

Enhancers for TRAK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRAK1 on UCSC Golden Path with GeneCards custom track

Promoters for TRAK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TRAK1 Gene

Chromosome:
3
Start:
42,013,802 bp from pter
End:
42,225,890 bp from pter
Size:
212,089 bases
Orientation:
Plus strand

Genomic View for TRAK1 Gene

Genes around TRAK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK1 Gene

Proteins for TRAK1 Gene

  • Protein details for TRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPV9-TRAK1_HUMAN
    Recommended name:
    Trafficking kinesin-binding protein 1
    Protein Accession:
    Q9UPV9
    Secondary Accessions:
    • E9PDS2
    • J3KNT7
    • Q63HR0
    • Q659B5
    • Q96B69

    Protein attributes for TRAK1 Gene

    Size:
    953 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 (By similarity). Interacts with KIF5C.
    Miscellaneous:
    • Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer.
    SequenceCaution:
    • Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAK1 Gene

Post-translational modifications for TRAK1 Gene

No data available for DME Specific Peptides for TRAK1 Gene

Domains & Families for TRAK1 Gene

Protein Domains for TRAK1 Gene

Suggested Antigen Peptide Sequences for TRAK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPV9

UniProtKB/Swiss-Prot:

TRAK1_HUMAN :
  • The C-terminal region is required for the early endosomal and mitochondrial localization.
Domain:
  • The C-terminal region is required for the early endosomal and mitochondrial localization.
  • Contains 1 HAP1 N-terminal domain.
genes like me logo Genes that share domains with TRAK1: view

No data available for Gene Families for TRAK1 Gene

Function for TRAK1 Gene

Molecular function for TRAK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Ontology (GO) - Molecular Function for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644324
GO:0050811 GABA receptor binding IEA --
genes like me logo Genes that share ontologies with TRAK1: view
genes like me logo Genes that share phenotypes with TRAK1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAK1 Gene

Localization for TRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK1 Gene

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAK1 Gene COMPARTMENTS Subcellular localization image for TRAK1 gene
Compartment Confidence
endosome 5
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 19528298
GO:0005739 mitochondrion IDA 15644324
GO:0005769 early endosome IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

Pathways & Interactions for TRAK1 Gene

SuperPathways for TRAK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0006493 protein O-linked glycosylation ISS --
GO:0006605 protein targeting ISS --
GO:0008333 endosome to lysosome transport IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

No data available for Pathways by source and SIGNOR curated interactions for TRAK1 Gene

Drugs & Compounds for TRAK1 Gene

No Compound Related Data Available

Transcripts for TRAK1 Gene

Unigene Clusters for TRAK1 Gene

Trafficking protein, kinesin binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: -
SP7: - -
SP8:

ExUns: 17c ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:

Relevant External Links for TRAK1 Gene

GeneLoc Exon Structure for
TRAK1
ECgene alternative splicing isoforms for
TRAK1

Expression for TRAK1 Gene

mRNA expression in normal human tissues for TRAK1 Gene

Protein differential expression in normal tissues from HIPED for TRAK1 Gene

This gene is overexpressed in Cervix (41.6), Heart (17.7), and Adipocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAK1 Gene



Protein tissue co-expression partners for TRAK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAK1 Gene:

TRAK1

SOURCE GeneReport for Unigene cluster for TRAK1 Gene:

Hs.535711

mRNA Expression by UniProt/SwissProt for TRAK1 Gene:

Q9UPV9-TRAK1_HUMAN
Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.
genes like me logo Genes that share expression patterns with TRAK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAK1 Gene

Orthologs for TRAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAK1 35
  • 100 (a)
OneToOne
TRAK1 34
  • 99.55 (n)
  • 99.79 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TRAK1 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trak1 35
  • 94 (a)
OneToOne
Trak1 16
Trak1 34
  • 88.45 (n)
  • 94.99 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAK1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAK1 35
  • 97 (a)
OneToOne
TRAK1 34
  • 91.82 (n)
  • 97.17 (a)
cow
(Bos Taurus)
Mammalia TRAK1 35
  • 89 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trak1 34
  • 88.17 (n)
  • 94.78 (a)
chicken
(Gallus gallus)
Aves TRAK1 35
  • 80 (a)
OneToOne
TRAK1 34
  • 80.16 (n)
  • 89.83 (a)
lizard
(Anolis carolinensis)
Reptilia TRAK1 35
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3942 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14348 34
zebrafish
(Danio rerio)
Actinopterygii TRAK1 (3 of 3) 35
  • 36 (a)
OneToMany
TRAK1 (2 of 3) 35
  • 48 (a)
OneToMany
trak1 35
  • 69 (a)
OneToMany
Dr.26160 34
fruit fly
(Drosophila melanogaster)
Insecta milt 35
  • 19 (a)
OneToMany
milt 34
  • 47.72 (n)
  • 38.46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008801 34
  • 48.26 (n)
  • 39.58 (a)
worm
(Caenorhabditis elegans)
Secernentea T27A3.1 35
  • 24 (a)
OneToMany
Species where no ortholog for TRAK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK1 Gene

ENSEMBL:
Gene Tree for TRAK1 (if available)
TreeFam:
Gene Tree for TRAK1 (if available)

Paralogs for TRAK1 Gene

Paralogs for TRAK1 Gene

(3) SIMAP similar genes for TRAK1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAK1: view

Variants for TRAK1 Gene

Sequence variations from dbSNP and Humsavar for TRAK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs875967 -- 42,043,241(+) ccttc(C/T)cctcc intron-variant
rs904269 -- 42,035,130(-) AGGTG(G/T)TTTAT intron-variant
rs904270 -- 42,016,871(-) AAGCT(C/G)TGGCA intron-variant
rs939561 -- 42,015,609(-) AAACG(C/T)TCCCA intron-variant
rs952731 -- 42,084,430(-) TTTTT(A/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAK1 Gene

Variant ID Type Subtype PubMed ID
dgv8295n54 CNV gain 21841781
esv2760776 CNV gain 21179565
esv32892 CNV gain 17666407
esv3595984 CNV gain 21293372
nsv1127953 CNV deletion 24896259
nsv460520 CNV gain 19166990
nsv834671 CNV gain 17160897

Variation tolerance for TRAK1 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK1 Gene

Disorders for TRAK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAK1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hypertonia
- elite association - COSMIC cancer census association via MalaCards
Search TRAK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAK1

Genetic Association Database (GAD)
TRAK1
Human Genome Epidemiology (HuGE) Navigator
TRAK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAK1
genes like me logo Genes that share disorders with TRAK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAK1 Gene

Publications for TRAK1 Gene

  1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer S.P.N. … Hart G.W. (J. Biol. Chem. 2003) 2 3 4 22 65
  2. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 65
  3. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K. … Stephenson F.A. (J. Biol. Chem. 2005) 3 4 22 65
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 65
  5. Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. (PMID: 20230862) Koutsopoulos O.S. … Ryan M.T. (Biochim. Biophys. Acta 2010) 2 3 65

Products for TRAK1 Gene

Sources for TRAK1 Gene

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