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Aliases for TRAK1 Gene

Aliases for TRAK1 Gene

  • Trafficking Protein, Kinesin Binding 1 2 3
  • OIP106 3 4 6
  • O-Linked N-Acetylglucosamine Transferase Interacting Protein 106 2 3
  • 106 KDa O-GlcNAc Transferase-Interacting Protein 3 4
  • KIAA1042 4 6
  • OGT(O Glc NAc Transferase) Interacting Protein 106 KDa 2
  • OGT(O-Glc-NAc Transferase)-Interacting Protein 106 KDa 3
  • Trafficking Kinesin-Binding Protein 1 3
  • Milton Homolog 1 (Drosophila) 2
  • Milton Homolog 1 3
  • MILT1 3

External Ids for TRAK1 Gene

Previous GeneCards Identifiers for TRAK1 Gene

  • GC03P042108

Summaries for TRAK1 Gene

GeneCards Summary for TRAK1 Gene

TRAK1 (Trafficking Protein, Kinesin Binding 1) is a Protein Coding gene. Diseases associated with TRAK1 include hypertonia. GO annotations related to this gene include GABA receptor binding. An important paralog of this gene is HAP1.

UniProtKB/Swiss-Prot for TRAK1 Gene

  • Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Wiki entry for TRAK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAK1 Gene

Genomics for TRAK1 Gene

Regulatory Elements for TRAK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAK1 Gene

42,013,802 bp from pter
42,225,890 bp from pter
212,089 bases
Plus strand

Genomic View for TRAK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAK1 Gene

Proteins for TRAK1 Gene

  • Protein details for TRAK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking kinesin-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • E9PDS2
    • J3KNT7
    • Q63HR0
    • Q659B5
    • Q96B69

    Protein attributes for TRAK1 Gene

    953 amino acids
    Molecular mass:
    106040 Da
    Quaternary structure:
    • Interacts with O-GlcNAc transferase. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2. Interacts with HGS. Interacts with GABRA1 (By similarity). Interacts with KIF5C.
    • Over-expressed in all investigated carcinomas, especially in gastric adenocarcinoma and signet-ring carcinoma and may serve as a marker of gastric cancer
    • Sequence=BAA82994.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAK1 Gene


neXtProt entry for TRAK1 Gene

Proteomics data for TRAK1 Gene at MOPED

Post-translational modifications for TRAK1 Gene

No data available for DME Specific Peptides for TRAK1 Gene

Domains for TRAK1 Gene

Protein Domains for TRAK1 Gene

Suggested Antigen Peptide Sequences for TRAK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UPV9
  • The C-terminal region is required for the early endosomal and mitochondrial localization
  • Contains 1 HAP1 N-terminal domain.
genes like me logo Genes that share domains with TRAK1: view

No data available for Gene Families for TRAK1 Gene

Function for TRAK1 Gene

Molecular function for TRAK1 Gene

UniProtKB/Swiss-Prot Function: Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors.

Gene Ontology (GO) - Molecular Function for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644324
GO:0050811 GABA receptor binding IEA --
genes like me logo Genes that share ontologies with TRAK1: view
genes like me logo Genes that share phenotypes with TRAK1: view

Animal Model Products

CRISPR Products

miRNA for TRAK1 Gene

miRTarBase miRNAs that target TRAK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAK1 Gene

Localization for TRAK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAK1 Gene

Cytoplasm. Nucleus. Mitochondrion. Early endosome. Endosome. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HRS. Colocalizes with MGARP at the mitochondria.

Subcellular locations from

Jensen Localization Image for TRAK1 Gene COMPARTMENTS Subcellular localization image for TRAK1 gene
Compartment Confidence
endosome 5
mitochondrion 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 19528298
GO:0005739 mitochondrion IDA 15644324
GO:0005769 early endosome IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

Pathways for TRAK1 Gene

SuperPathways for TRAK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0006493 protein O-linked glycosylation ISS --
GO:0006605 protein targeting ISS --
GO:0008333 endosome to lysosome transport IDA 18675823
genes like me logo Genes that share ontologies with TRAK1: view

No data available for Pathways by source for TRAK1 Gene

Transcripts for TRAK1 Gene

Unigene Clusters for TRAK1 Gene

Trafficking protein, kinesin binding 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: -
SP7: - -

ExUns: 17c ^ 18a · 18b ^ 19a · 19b
SP1: -
SP5: -
SP6: -

Relevant External Links for TRAK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAK1 Gene

mRNA expression in normal human tissues for TRAK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAK1 Gene

SOURCE GeneReport for Unigene cluster for TRAK1 Gene Hs.535711

mRNA Expression by UniProt/SwissProt for TRAK1 Gene

Tissue specificity: High expression in spinal cord and moderate expression in all other tissues and specific brain regions examined. Expressed in all cell lines examined.
genes like me logo Genes that share expressions with TRAK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAK1 Gene

Orthologs for TRAK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAK1 35
  • 99.55 (n)
  • 99.79 (a)
TRAK1 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
TRAK1 36
  • 89 (a)
(Canis familiaris)
Mammalia TRAK1 35
  • 91.82 (n)
  • 97.17 (a)
TRAK1 36
  • 97 (a)
(Mus musculus)
Mammalia Trak1 35
  • 88.45 (n)
  • 94.99 (a)
Trak1 16
Trak1 36
  • 94 (a)
(Monodelphis domestica)
Mammalia TRAK1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TRAK1 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Trak1 35
  • 88.17 (n)
  • 94.78 (a)
(Gallus gallus)
Aves TRAK1 35
  • 80.16 (n)
  • 89.83 (a)
TRAK1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia TRAK1 36
  • 75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3942 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14348 35
(Danio rerio)
Actinopterygii Dr.26160 35
trak1 36
  • 69 (a)
TRAK1 (2 of 3) 36
  • 48 (a)
TRAK1 (3 of 3) 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008801 35
  • 48.26 (n)
  • 39.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta milt 35
  • 47.72 (n)
  • 38.46 (a)
milt 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea T27A3.1 36
  • 24 (a)
Species with no ortholog for TRAK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAK1 Gene

Gene Tree for TRAK1 (if available)
Gene Tree for TRAK1 (if available)

Paralogs for TRAK1 Gene

Paralogs for TRAK1 Gene

Selected SIMAP similar genes for TRAK1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAK1: view

Variants for TRAK1 Gene

Sequence variations from dbSNP and Humsavar for TRAK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8528 -- 42,212,598(-) TTAAT(A/C)ATCTA intron-variant, utr-variant-3-prime
rs9156 -- 42,225,341(-) TCCTT(G/T)GTGGA utr-variant-3-prime
rs9511 -- 42,212,265(+) TAATC(C/T)GTCCT intron-variant, utr-variant-3-prime
rs9747 -- 42,212,241(+) CATGG(C/T)GGTCT intron-variant, utr-variant-3-prime
rs12554 -- 42,224,708(-) TTCTT(A/T)AATAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAK1 Gene

Variant ID Type Subtype PubMed ID
nsv460520 CNV Gain 19166990
esv32892 CNV Gain 17666407
nsv834671 CNV Gain 17160897

Relevant External Links for TRAK1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAK1 Gene

Disorders for TRAK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAK1 Gene including...

Search for TRAK1 Gene in MalaCards »

Relevant External Links for TRAK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRAK1: view

No data available for UniProtKB/Swiss-Prot for TRAK1 Gene

Publications for TRAK1 Gene

  1. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. (PMID: 12435728) Iyer S.P.N. … Hart G.W. (J. Biol. Chem. 2003) 2 3 4 23
  2. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. (PMID: 15644324) Brickley K. … Stephenson F.A. (J. Biol. Chem. 2005) 3 4 23
  3. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAK1 Gene

Sources for TRAK1 Gene

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