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Aliases for TRAJ8 Gene

Aliases for TRAJ8 Gene

  • T-Cell Receptor Alpha Joining 8 2 5
  • T Cell Receptor Alpha Joining 8 2 3

External Ids for TRAJ8 Gene

Previous GeneCards Identifiers for TRAJ8 Gene

  • GC14U990383
  • GC14P020995
  • GC14P022077
  • GC14P023061
  • GC14P023125
  • GC14P023187
  • GC14P023238
  • GC14P023300
  • GC14P023378
  • GC14P023449
  • GC14P023533
  • GC14P023624
  • GC14P023764
  • GC14P022557
  • GC14P022660
  • GC14P022731
  • GC14P022810
  • GC14P023805
  • GC14P023901

Summaries for TRAJ8 Gene

Entrez Gene Summary for TRAJ8 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ8 Gene

TRAJ8 (T-Cell Receptor Alpha Joining 8) is an Uncategorized gene.

Additional gene information for TRAJ8 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAJ8 Gene

Genomics for TRAJ8 Gene

Genomic Location for TRAJ8 Gene

Chromosome:
14
Start:
22,536,145 bp from pter
End:
22,536,204 bp from pter
Size:
60 bases
Orientation:
Plus strand

Genomic View for TRAJ8 Gene

Genes around TRAJ8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ8 Gene

No data available for Regulatory Elements for TRAJ8 Gene

Proteins for TRAJ8 Gene

Post-translational modifications for TRAJ8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRAJ8 Gene

Domains & Families for TRAJ8 Gene

Gene Families for TRAJ8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAJ8: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAJ8 Gene

Function for TRAJ8 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAJ8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ8 Gene

Localization for TRAJ8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAJ8 Gene

Pathways & Interactions for TRAJ8 Gene

SuperPathways for TRAJ8 Gene

No Data Available

Interacting Proteins for TRAJ8 Gene

Gene Ontology (GO) - Biological Process for TRAJ8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAJ8 Gene

Drugs & Compounds for TRAJ8 Gene

No Compound Related Data Available

Transcripts for TRAJ8 Gene

mRNA/cDNA for TRAJ8 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAJ8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ8 Gene

No ASD Table

Relevant External Links for TRAJ8 Gene

GeneLoc Exon Structure for
TRAJ8
ECgene alternative splicing isoforms for
TRAJ8

Expression for TRAJ8 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAJ8 Gene:

TRAJ8
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAJ8 Gene

Orthologs for TRAJ8 Gene

Evolution for TRAJ8 Gene

ENSEMBL:
Gene Tree for TRAJ8 (if available)
TreeFam:
Gene Tree for TRAJ8 (if available)

No data available for Orthologs for TRAJ8 Gene

Paralogs for TRAJ8 Gene

No data available for Paralogs for TRAJ8 Gene

Variants for TRAJ8 Gene

Relevant External Links for TRAJ8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ8 Gene

Disorders for TRAJ8 Gene

No disorders were found for TRAJ8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAJ8 Gene

Publications for TRAJ8 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 60

Products for TRAJ8 Gene

Sources for TRAJ8 Gene

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