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Aliases for TRAJ60 Gene

Aliases for TRAJ60 Gene

  • T-Cell Receptor Alpha Joining 60 (Pseudogene) 2 5
  • T Cell Receptor Alpha Joining 60 (Pseudogene) 2 3
  • T Cell Receptor Alpha Joining 60 Pseudogene 2
  • T Cell Receptor Alpha Joining 60 2
  • TCRA 3

External Ids for TRAJ60 Gene

Previous GeneCards Identifiers for TRAJ60 Gene

  • GC14U990331
  • GC14P020935
  • GC14P022016
  • GC14P022949
  • GC14P023072
  • GC14P023134
  • GC14P023244
  • GC14P023307
  • GC14P023347
  • GC14P023420
  • GC14P023476
  • GC14P023565
  • GC14P023706
  • GC14P022481

Summaries for TRAJ60 Gene

Entrez Gene Summary for TRAJ60 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ60 Gene

TRAJ60 (T-Cell Receptor Alpha Joining 60 (Pseudogene)) is a Pseudogene.

Additional gene information for TRAJ60 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAJ60 Gene

Genomics for TRAJ60 Gene

Genomic Location for TRAJ60 Gene

Chromosome:
14
Start:
22,476,306 bp from pter
End:
22,476,362 bp from pter
Size:
57 bases
Orientation:
Plus strand

Genomic View for TRAJ60 Gene

Genes around TRAJ60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ60 Gene

No data available for Regulatory Elements for TRAJ60 Gene

Proteins for TRAJ60 Gene

Post-translational modifications for TRAJ60 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRAJ60 Gene

Domains & Families for TRAJ60 Gene

Gene Families for TRAJ60 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAJ60: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAJ60 Gene

Function for TRAJ60 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAJ60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ60 Gene

Localization for TRAJ60 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TRAJ60 Gene

Pathways & Interactions for TRAJ60 Gene

SuperPathways for TRAJ60 Gene

No Data Available

Interacting Proteins for TRAJ60 Gene

Gene Ontology (GO) - Biological Process for TRAJ60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAJ60 Gene

Drugs & Compounds for TRAJ60 Gene

No Compound Related Data Available

Transcripts for TRAJ60 Gene

mRNA/cDNA for TRAJ60 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TRAJ60
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ60 Gene

No ASD Table

Relevant External Links for TRAJ60 Gene

GeneLoc Exon Structure for
TRAJ60
ECgene alternative splicing isoforms for
TRAJ60

Expression for TRAJ60 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAJ60 Gene:

TRAJ60
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAJ60 Gene

Orthologs for TRAJ60 Gene

Evolution for TRAJ60 Gene

ENSEMBL:
Gene Tree for TRAJ60 (if available)
TreeFam:
Gene Tree for TRAJ60 (if available)

No data available for Orthologs for TRAJ60 Gene

Paralogs for TRAJ60 Gene

No data available for Paralogs for TRAJ60 Gene

Variants for TRAJ60 Gene

Relevant External Links for TRAJ60 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ60 Gene

Disorders for TRAJ60 Gene

Relevant External Links for TRAJ60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAJ60

No disorders were found for TRAJ60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAJ60 Gene

Publications for TRAJ60 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 60
  2. Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes. (PMID: 3494611) Kimura N … Mak TW (European journal of immunology 1987) 3 60

Products for TRAJ60 Gene

Sources for TRAJ60 Gene

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