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Aliases for TRAJ46 Gene

Aliases for TRAJ46 Gene

  • T Cell Receptor Alpha Joining 46 2 3 5

External Ids for TRAJ46 Gene

Previous GeneCards Identifiers for TRAJ46 Gene

  • GC14U990345
  • GC14P020952
  • GC14P022032
  • GC14P023020
  • GC14P023085
  • GC14P023146
  • GC14P023199
  • GC14P023260
  • GC14P023323
  • GC14P023401
  • GC14P023491
  • GC14P023581
  • GC14P023722
  • GC14P022496
  • GC14P022571
  • GC14P022758
  • GC14P022846

Summaries for TRAJ46 Gene

Entrez Gene Summary for TRAJ46 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ46 Gene

TRAJ46 (T Cell Receptor Alpha Joining 46) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAJ46 Gene

Genomics for TRAJ46 Gene

Genomic Location for TRAJ46 Gene

Chromosome:
14
Start:
22,493,403 bp from pter
End:
22,493,465 bp from pter
Size:
63 bases
Orientation:
Plus strand

Genomic View for TRAJ46 Gene

Genes around TRAJ46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ46 Gene

No data available for Regulatory Elements for TRAJ46 Gene

Proteins for TRAJ46 Gene

  • Protein details for TRAJ46 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B6W4
    Recommended name:
    Protein TRAJ46
    Protein Accession:
    A0A075B6W4

    Protein attributes for TRAJ46 Gene

    Size:
    21 amino acids
    Molecular mass:
    2231 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAJ46 Gene

Post-translational modifications for TRAJ46 Gene

No Post-translational modifications

Other Protein References for TRAJ46 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAJ46 Gene

Domains & Families for TRAJ46 Gene

Gene Families for TRAJ46 Gene

Protein Domains for TRAJ46 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAJ46: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAJ46 Gene

Function for TRAJ46 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ46 Gene

Localization for TRAJ46 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAJ46 Gene

Pathways & Interactions for TRAJ46 Gene

SuperPathways for TRAJ46 Gene

No Data Available

Interacting Proteins for TRAJ46 Gene

Gene Ontology (GO) - Biological Process for TRAJ46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAJ46 Gene

Transcripts for TRAJ46 Gene

mRNA/cDNA for TRAJ46 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ46 Gene

No ASD Table

Relevant External Links for TRAJ46 Gene

GeneLoc Exon Structure for
TRAJ46
ECgene alternative splicing isoforms for
TRAJ46

Expression for TRAJ46 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAJ46 Gene:

TRAJ46
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAJ46 Gene

Orthologs for TRAJ46 Gene

Evolution for TRAJ46 Gene

ENSEMBL:
Gene Tree for TRAJ46 (if available)
TreeFam:
Gene Tree for TRAJ46 (if available)

No data available for Orthologs for TRAJ46 Gene

Paralogs for TRAJ46 Gene

No data available for Paralogs for TRAJ46 Gene

Variants for TRAJ46 Gene

Relevant External Links for TRAJ46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ46 Gene

Disorders for TRAJ46 Gene

No disorders were found for TRAJ46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAJ46 Gene

Publications for TRAJ46 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAJ46 Gene

Sources for TRAJ46 Gene

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