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Aliases for TRAJ43 Gene

Aliases for TRAJ43 Gene

  • T-Cell Receptor Alpha Joining 43 2 5
  • T Cell Receptor Alpha Joining 43 2 3

External Ids for TRAJ43 Gene

Previous GeneCards Identifiers for TRAJ43 Gene

  • GC14U990348
  • GC14P020955
  • GC14P022035
  • GC14P023024
  • GC14P023088
  • GC14P023149
  • GC14P023202
  • GC14P023263
  • GC14P023326
  • GC14P023404
  • GC14P023495
  • GC14P023584
  • GC14P023725
  • GC14P022499
  • GC14P022585
  • GC14P022763
  • GC14P022864
  • GC14P023823

Summaries for TRAJ43 Gene

Entrez Gene Summary for TRAJ43 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ43 Gene

TRAJ43 (T-Cell Receptor Alpha Joining 43) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAJ43 Gene

Genomics for TRAJ43 Gene

Genomic Location for TRAJ43 Gene

Chromosome:
14
Start:
22,495,913 bp from pter
End:
22,495,966 bp from pter
Size:
54 bases
Orientation:
Plus strand

Genomic View for TRAJ43 Gene

Genes around TRAJ43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ43 Gene

No data available for Regulatory Elements for TRAJ43 Gene

Proteins for TRAJ43 Gene

  • Protein details for TRAJ43 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A075B6V1
    Recommended name:
    T-cell receptor alpha joining 43
    Protein Accession:
    A0A075B6V1

    Protein attributes for TRAJ43 Gene

    Size:
    18 amino acids
    Molecular mass:
    2002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRAJ43 Gene

Post-translational modifications for TRAJ43 Gene

No Post-translational modifications

Other Protein References for TRAJ43 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAJ43 Gene

Domains & Families for TRAJ43 Gene

Gene Families for TRAJ43 Gene

Protein Domains for TRAJ43 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAJ43: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAJ43 Gene

Function for TRAJ43 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ43 Gene

Localization for TRAJ43 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAJ43 Gene

Pathways & Interactions for TRAJ43 Gene

SuperPathways for TRAJ43 Gene

No Data Available

Interacting Proteins for TRAJ43 Gene

Gene Ontology (GO) - Biological Process for TRAJ43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAJ43 Gene

Drugs & Compounds for TRAJ43 Gene

No Compound Related Data Available

Transcripts for TRAJ43 Gene

mRNA/cDNA for TRAJ43 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ43 Gene

No ASD Table

Relevant External Links for TRAJ43 Gene

GeneLoc Exon Structure for
TRAJ43
ECgene alternative splicing isoforms for
TRAJ43

Expression for TRAJ43 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAJ43 Gene:

TRAJ43
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAJ43 Gene

Orthologs for TRAJ43 Gene

Evolution for TRAJ43 Gene

ENSEMBL:
Gene Tree for TRAJ43 (if available)
TreeFam:
Gene Tree for TRAJ43 (if available)

No data available for Orthologs for TRAJ43 Gene

Paralogs for TRAJ43 Gene

No data available for Paralogs for TRAJ43 Gene

Variants for TRAJ43 Gene

Relevant External Links for TRAJ43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ43 Gene

Disorders for TRAJ43 Gene

No disorders were found for TRAJ43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAJ43 Gene

Publications for TRAJ43 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64

Products for TRAJ43 Gene

Sources for TRAJ43 Gene

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