Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRAJ15 Gene

Aliases for TRAJ15 Gene

  • T Cell Receptor Alpha Joining 15 2 3

External Ids for TRAJ15 Gene

Previous GeneCards Identifiers for TRAJ15 Gene

  • GC14U990376
  • GC14P020988
  • GC14P022068
  • GC14P023054
  • GC14P023118
  • GC14P023180
  • GC14P023230
  • GC14P023292
  • GC14P023371
  • GC14P023441
  • GC14P023525
  • GC14P023617
  • GC14P023755

Summaries for TRAJ15 Gene

Entrez Gene Summary for TRAJ15 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAJ15 Gene

TRAJ15 (T Cell Receptor Alpha Joining 15) is an Uncategorized gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAJ15 Gene

Genomics for TRAJ15 Gene

Genomic Location for TRAJ15 Gene

Chromosome:
14
Start:
22,529,629 bp from pter
End:
22,529,688 bp from pter
Size:
60 bases
Orientation:
Plus strand

Genomic View for TRAJ15 Gene

Genes around TRAJ15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAJ15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAJ15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAJ15 Gene

No data available for Regulatory Elements for TRAJ15 Gene

Proteins for TRAJ15 Gene

Post-translational modifications for TRAJ15 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRAJ15 Gene

Domains & Families for TRAJ15 Gene

Gene Families for TRAJ15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAJ15: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRAJ15 Gene

Function for TRAJ15 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAJ15 Gene

Localization for TRAJ15 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRAJ15 Gene

Pathways & Interactions for TRAJ15 Gene

SuperPathways for TRAJ15 Gene

No Data Available

Interacting Proteins for TRAJ15 Gene

Gene Ontology (GO) - Biological Process for TRAJ15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAJ15 Gene

Transcripts for TRAJ15 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRAJ15 Gene

No ASD Table

Relevant External Links for TRAJ15 Gene

GeneLoc Exon Structure for
TRAJ15
ECgene alternative splicing isoforms for
TRAJ15

Expression for TRAJ15 Gene

mRNA expression in normal human tissues for TRAJ15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAJ15 Gene:

TRAJ15
genes like me logo Genes that share expression patterns with TRAJ15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRAJ15 Gene

Orthologs for TRAJ15 Gene

No data available for Orthologs and Evolution for TRAJ15 Gene

Paralogs for TRAJ15 Gene

No data available for Paralogs for TRAJ15 Gene

Variants for TRAJ15 Gene

Relevant External Links for TRAJ15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAJ15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAJ15 Gene

Disorders for TRAJ15 Gene

No disorders were found for TRAJ15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAJ15 Gene

Publications for TRAJ15 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3 64
  2. Human T-cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32. (PMID: 3117531) Mengle-Gaw L. … Rabbitts T.H. (EMBO J. 1987) 2 3 64

Products for TRAJ15 Gene

Sources for TRAJ15 Gene

Content
Loading form....