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Aliases for TRAIP Gene

Aliases for TRAIP Gene

  • TRAF Interacting Protein 2 3
  • RNF206 3 4 6
  • TRIP 3 4 6
  • TRAF-Interacting Protein 3 4
  • Ring Finger Protein 206 2 3
  • E3 Ubiquitin-Protein Ligase TRAIP 3
  • RING Finger Protein 206 4
  • EC 6.3.2.- 4

External Ids for TRAIP Gene

Previous GeneCards Identifiers for TRAIP Gene

  • GC03M049843
  • GC03M049866

Summaries for TRAIP Gene

Entrez Gene Summary for TRAIP Gene

  • This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAIP Gene

TRAIP (TRAF Interacting Protein) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include receptor signaling protein activity.

UniProtKB/Swiss-Prot for TRAIP Gene

  • Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting Lys-48-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of Lys-63-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.

Gene Wiki entry for TRAIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAIP Gene

Genomics for TRAIP Gene

Regulatory Elements for TRAIP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAIP Gene

Start:
49,828,595 bp from pter
End:
49,856,574 bp from pter
Size:
27,980 bases
Orientation:
Minus strand

Genomic View for TRAIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAIP Gene

Proteins for TRAIP Gene

  • Protein details for TRAIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWF2-TRAIP_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRAIP
    Protein Accession:
    Q9BWF2
    Secondary Accessions:
    • B5BU84
    • B5BUL3
    • O00467

    Protein attributes for TRAIP Gene

    Size:
    469 amino acids
    Molecular mass:
    53294 Da
    Quaternary structure:
    • Binds TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 is part of the receptor-TRAF signaling complex (By similarity). The C-terminus interacts with CYLD (PubMed:14676304), however the interaction was not detected with the full-length protein. Interacts with POLK and POLN.

neXtProt entry for TRAIP Gene

Proteomics data for TRAIP Gene at MOPED

Post-translational modifications for TRAIP Gene

Other Protein References for TRAIP Gene

No data available for DME Specific Peptides for TRAIP Gene

Domains for TRAIP Gene

Gene Families for TRAIP Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for TRAIP Gene

Suggested Antigen Peptide Sequences for TRAIP Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWF2

UniProtKB/Swiss-Prot:

TRAIP_HUMAN :
  • Q9BWF2
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRAIP: view

Function for TRAIP Gene

Molecular function for TRAIP Gene

UniProtKB/Swiss-Prot Function: Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting Lys-48-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of Lys-63-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.

Enzyme Numbers (IUBMB) for TRAIP Gene

Gene Ontology (GO) - Molecular Function for TRAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005057 receptor signaling protein activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRAIP: view
genes like me logo Genes that share phenotypes with TRAIP: view

Animal Models for TRAIP Gene

MGI Knock Outs for TRAIP:

Animal Model Products

CRISPR Products

miRNA for TRAIP Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAIP

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TRAIP Gene

Localization for TRAIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAIP Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAIP Gene COMPARTMENTS Subcellular localization image for TRAIP gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TRAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TRAIP: view

Pathways for TRAIP Gene

genes like me logo Genes that share pathways with TRAIP: view

Pathways by source for TRAIP Gene

1 BioSystems pathway for TRAIP Gene

PCR Array Products

UniProtKB/Swiss-Prot Q9BWF2-TRAIP_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRAIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 9104814
GO:0007165 signal transduction TAS 9104814
GO:0008283 cell proliferation TAS 9104814
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA 19151749
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRAIP: view

Transcripts for TRAIP Gene

Unigene Clusters for TRAIP Gene

TRAF interacting protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7: -

Relevant External Links for TRAIP Gene

GeneLoc Exon Structure for
TRAIP
ECgene alternative splicing isoforms for
TRAIP

Expression for TRAIP Gene

mRNA expression in normal human tissues for TRAIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAIP Gene

This gene is overexpressed in Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRAIP Gene

SOURCE GeneReport for Unigene cluster for TRAIP Gene Hs.517972

genes like me logo Genes that share expressions with TRAIP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRAIP Gene

Orthologs for TRAIP Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAIP 35
  • 99.43 (n)
  • 99.15 (a)
TRAIP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAIP 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAIP 35
  • 86.25 (n)
  • 84.83 (a)
TRAIP 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traip 35
  • 84.58 (n)
  • 79.87 (a)
Traip 16
Traip 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAIP 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAIP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traip 35
  • 84.41 (n)
  • 81.76 (a)
chicken
(Gallus gallus)
Aves TRAIP 35
  • 66.15 (n)
  • 61.89 (a)
TRAIP 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAIP 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21313 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2517 35
traip 35
  • 59.39 (n)
  • 55.24 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.13637 35
traip 35
  • 58.43 (n)
  • 53.32 (a)
traip 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nopo 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0432.13 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
Species with no ortholog for TRAIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAIP Gene

ENSEMBL:
Gene Tree for TRAIP (if available)
TreeFam:
Gene Tree for TRAIP (if available)

Paralogs for TRAIP Gene

Selected SIMAP similar genes for TRAIP Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAIP: view

No data available for Paralogs for TRAIP Gene

Variants for TRAIP Gene

Sequence variations from dbSNP and Humsavar for TRAIP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs695238 -- 49,831,725(+) TGAGA(A/C)AAGAG intron-variant
rs939376 -- 49,841,769(+) TGACA(C/T)GGCTG intron-variant
rs1110295 -- 49,843,510(+) CCCAG(C/T)CTCAC intron-variant
rs1128535 -- 49,828,959(-) GTGTG(A/G/T)CACCC utr-variant-3-prime
rs1139895 -- 49,829,015(-) AGCCC(C/T)ACTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAIP Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294

Relevant External Links for TRAIP Gene

HapMap Linkage Disequilibrium report
TRAIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAIP Gene

Disorders for TRAIP Gene

Relevant External Links for TRAIP

Genetic Association Database (GAD)
TRAIP
Human Genome Epidemiology (HuGE) Navigator
TRAIP
genes like me logo Genes that share disorders with TRAIP: view

No data available for UniProtKB/Swiss-Prot for TRAIP Gene

Publications for TRAIP Gene

  1. TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. (PMID: 9104814) Lee S.Y. … Choi Y. (J. Exp. Med. 1997) 2 3 4 23
  2. TRAF-interacting protein (TRIP) negatively regulates IFN-I^ production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. (PMID: 22945920) Zhang M. … Gao C. (J. Exp. Med. 2012) 3 4
  3. TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase eta. (PMID: 24553286) Wallace H.A. … Lee L.A. (Development 2014) 3 4
  4. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. (PMID: 14676304) Regamey A. … Huber M. (J. Exp. Med. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRAIP Gene

Sources for TRAIP Gene

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