Aliases for TRAIP Gene
External Ids for TRAIP Gene
Previous GeneCards Identifiers for TRAIP Gene
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRAIP Gene
TRAIP (TRAF Interacting Protein) is a Protein Coding gene. Diseases associated with TRAIP include seckel syndrome. Among its related pathways are Immune System and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include ligase activity and receptor signaling protein activity.
UniProtKB/Swiss-Prot for TRAIP Gene
Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting Lys-48-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of Lys-63-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity.