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Aliases for TRAFD1 Gene

Aliases for TRAFD1 Gene

  • TRAF-Type Zinc Finger Domain Containing 1 2 3
  • FLN29 3 4 6
  • TRAF-Type Zinc Finger Domain-Containing Protein 1 3
  • FLN29 Gene Product 3
  • Protein FLN29 4

External Ids for TRAFD1 Gene

Summaries for TRAFD1 Gene

Entrez Gene Summary for TRAFD1 Gene

  • The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

GeneCards Summary for TRAFD1 Gene

TRAFD1 (TRAF-Type Zinc Finger Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is XAF1.

UniProtKB/Swiss-Prot for TRAFD1 Gene

  • Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).

Gene Wiki entry for TRAFD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAFD1 Gene

Genomics for TRAFD1 Gene

Genomic Location for TRAFD1 Gene

Start:
112,125,501 bp from pter
End:
112,153,609 bp from pter
Size:
28,109 bases
Orientation:
Plus strand

Genomic View for TRAFD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAFD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAFD1 Gene

Regulatory Elements for TRAFD1 Gene

Proteins for TRAFD1 Gene

  • Protein details for TRAFD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14545-TRAD1_HUMAN
    Recommended name:
    TRAF-type zinc finger domain-containing protein 1
    Protein Accession:
    O14545
    Secondary Accessions:
    • A8K5L6
    • B4DI89

    Protein attributes for TRAFD1 Gene

    Size:
    582 amino acids
    Molecular mass:
    64841 Da
    Quaternary structure:
    • Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 (By similarity). Interacts with TRAF6.

    Three dimensional structures from OCA and Proteopedia for TRAFD1 Gene

    Alternative splice isoforms for TRAFD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAFD1 Gene

Proteomics data for TRAFD1 Gene at MOPED

Post-translational modifications for TRAFD1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys283 and Lys485

No data available for DME Specific Peptides for TRAFD1 Gene

Domains for TRAFD1 Gene

Protein Domains for TRAFD1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TRAD1_HUMAN
Similarity:
  • Contains 1 TRAF-type zinc finger.:
    • O14545
genes like me logo Genes that share domains with TRAFD1: view

No data available for Gene Families for TRAFD1 Gene

Function for TRAFD1 Gene

Molecular function for TRAFD1 Gene

UniProtKB/Swiss-Prot Function: Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3 (By similarity).

Gene Ontology (GO) - Molecular Function for TRAFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17500595
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRAFD1: view
genes like me logo Genes that share phenotypes with TRAFD1: view

Animal Models for TRAFD1 Gene

MGI Knock Outs for TRAFD1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRAFD1 Gene

Localization for TRAFD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAFD1 Gene COMPARTMENTS Subcellular localization image for TRAFD1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TRAFD1 Gene

Pathways for TRAFD1 Gene

SuperPathways for TRAFD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAFD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034097 response to cytokine IEA --
GO:0045824 negative regulation of innate immune response ISS --
genes like me logo Genes that share ontologies with TRAFD1: view

No data available for Pathways by source for TRAFD1 Gene

Transcripts for TRAFD1 Gene

Unigene Clusters for TRAFD1 Gene

TRAF-type zinc finger domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAFD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6: - - -

Relevant External Links for TRAFD1 Gene

GeneLoc Exon Structure for
TRAFD1
ECgene alternative splicing isoforms for
TRAFD1

Expression for TRAFD1 Gene

mRNA expression in normal human tissues for TRAFD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRAFD1 Gene

SOURCE GeneReport for Unigene cluster for TRAFD1 Gene Hs.5148

genes like me logo Genes that share expressions with TRAFD1: view

Orthologs for TRAFD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRAFD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAFD1 36
  • 99.43 (n)
  • 98.45 (a)
TRAFD1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAFD1 36
  • 86.38 (n)
  • 79.3 (a)
TRAFD1 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAFD1 36
  • 88.6 (n)
  • 84.03 (a)
TRAFD1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trafd1 36
  • 81.16 (n)
  • 76.35 (a)
Trafd1 16
Trafd1 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAFD1 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAFD1 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trafd1 36
  • 81.88 (n)
  • 76.13 (a)
chicken
(Gallus gallus)
Aves TRAFD1 36
  • 58.13 (n)
  • 49.47 (a)
TRAFD1 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAFD1 37
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TRAFD1 37
  • 31 (a)
OneToOne
zgc:162228 36
  • 51.92 (n)
  • 43.51 (a)
Species with no ortholog for TRAFD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRAFD1 Gene

ENSEMBL:
Gene Tree for TRAFD1 (if available)
TreeFam:
Gene Tree for TRAFD1 (if available)

Paralogs for TRAFD1 Gene

Paralogs for TRAFD1 Gene

Selected SIMAP similar genes for TRAFD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAFD1: view

Variants for TRAFD1 Gene

Sequence variations from dbSNP and Humsavar for TRAFD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs882919 -- 112,148,558(+) TTTGA(G/T)CAGGT intron-variant
rs1043201 -- 112,153,476(+) ATGTT(G/T)GGCTC utr-variant-3-prime
rs1043203 -- 112,153,503(+) TTGCT(C/T)TGAAA utr-variant-3-prime
rs1815186 -- 112,138,771(-) aagca(A/T)ttctc intron-variant
rs2056698 -- 112,131,299(-) TGTCT(A/C)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAFD1 Gene

Variant ID Type Subtype PubMed ID
nsv483114 CNV Gain 15286789

Relevant External Links for TRAFD1 Gene

HapMap Linkage Disequilibrium report
TRAFD1

Disorders for TRAFD1 Gene

Relevant External Links for TRAFD1

Genetic Association Database (GAD)
TRAFD1
genes like me logo Genes that share disorders with TRAFD1: view

No data available for UniProtKB/Swiss-Prot for TRAFD1 Gene

Publications for TRAFD1 Gene

  1. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. (PMID: 19862010) Ganesh S.K. … Lin J.P. (Nat. Genet. 2009) 3 49
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling. (PMID: 16221674) Mashima R. … Yoshimura A. (J. Biol. Chem. 2005) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for TRAFD1 Gene

Sources for TRAFD1 Gene

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