Aliases for TRAF7 Gene
External Ids for TRAF7 Gene
Previous HGNC Symbols for TRAF7 Gene
Previous GeneCards Identifiers for TRAF7 Gene
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
GeneCards Summary for TRAF7 Gene
TRAF7 (TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with TRAF7 include secretory meningioma and central nervous system cancer. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ZNF106.
UniProtKB/Swiss-Prot for TRAF7 Gene
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.