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Aliases for TRAF7 Gene

Aliases for TRAF7 Gene

  • TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase 2 3
  • RFWD1 3 4 6
  • RING Finger And WD Repeat-Containing Protein 1 3 4
  • Ring Finger And WD Repeat Domain 1 2 3
  • TNF Receptor-Associated Factor 7 2 4
  • RING Finger Protein 119 3 4
  • RNF119 3 4
  • E3 Ubiquitin-Protein Ligase TRAF7 3
  • EC 6.3.2.- 4

External Ids for TRAF7 Gene

Previous HGNC Symbols for TRAF7 Gene

  • RFWD1

Previous GeneCards Identifiers for TRAF7 Gene

  • GC16P002125
  • GC16P002146
  • GC16P002147
  • GC16P002205
  • GC16P002132

Summaries for TRAF7 Gene

Entrez Gene Summary for TRAF7 Gene

  • Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

GeneCards Summary for TRAF7 Gene

TRAF7 (TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with TRAF7 include secretory meningioma. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and SMAD Signaling Network. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZNF106.

UniProtKB/Swiss-Prot for TRAF7 Gene

  • E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF7 Gene

Genomics for TRAF7 Gene

Regulatory Elements for TRAF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRAF7 Gene

2,155,698 bp from pter
2,178,129 bp from pter
22,432 bases
Plus strand

Genomic View for TRAF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF7 Gene

Proteins for TRAF7 Gene

  • Protein details for TRAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRAF7
    Protein Accession:
    Secondary Accessions:
    • Q9H073

    Protein attributes for TRAF7 Gene

    670 amino acids
    Molecular mass:
    74609 Da
    Quaternary structure:
    • Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.

    Alternative splice isoforms for TRAF7 Gene


neXtProt entry for TRAF7 Gene

Proteomics data for TRAF7 Gene at MOPED

Post-translational modifications for TRAF7 Gene

Other Protein References for TRAF7 Gene

No data available for DME Specific Peptides for TRAF7 Gene

Domains for TRAF7 Gene

Gene Families for TRAF7 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TRAF7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6Q0C0
  • Belongs to the WD repeat TRAF7 family.
  • Contains 1 RING-type zinc finger.
  • Contains 1 TRAF-type zinc finger.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TRAF7: view

Function for TRAF7 Gene

Molecular function for TRAF7 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.

Enzyme Numbers (IUBMB) for TRAF7 Gene

Gene Ontology (GO) - Molecular Function for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14743216
GO:0005515 protein binding IPI 14743216
GO:0008270 zinc ion binding NAS 14743216
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRAF7: view

Animal Model Products

CRISPR Products

miRNA for TRAF7 Gene

miRTarBase miRNAs that target TRAF7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF7

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAF7 Gene

Localization for TRAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF7 Gene

Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

Subcellular locations from

Jensen Localization Image for TRAF7 Gene COMPARTMENTS Subcellular localization image for TRAF7 gene
Compartment Confidence
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14743216
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with TRAF7: view

Pathways for TRAF7 Gene

genes like me logo Genes that share pathways with TRAF7: view

Pathways by source for TRAF7 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q6Q0C0-TRAF7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000185 activation of MAPKKK activity IDA 14743216
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006915 apoptotic process IDA 15001576
genes like me logo Genes that share ontologies with TRAF7: view

Transcripts for TRAF7 Gene

Unigene Clusters for TRAF7 Gene

TNF receptor-associated factor 7, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRAF7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRAF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP7: -
SP9: -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22

Relevant External Links for TRAF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAF7 Gene

mRNA expression in normal human tissues for TRAF7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF7 Gene

SOURCE GeneReport for Unigene cluster for TRAF7 Gene Hs.713632

mRNA Expression by UniProt/SwissProt for TRAF7 Gene

Tissue specificity: Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.
genes like me logo Genes that share expressions with TRAF7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAF7 Gene

Orthologs for TRAF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAF7 35
  • 99.55 (n)
  • 99.85 (a)
TRAF7 36
  • 100 (a)
(Bos Taurus)
Mammalia TRAF7 35
  • 92.18 (n)
  • 97.91 (a)
TRAF7 36
  • 98 (a)
(Canis familiaris)
Mammalia TRAF7 35
  • 91.89 (n)
  • 98.21 (a)
TRAF7 36
  • 98 (a)
(Mus musculus)
Mammalia Traf7 35
  • 88.44 (n)
  • 96.71 (a)
Traf7 16
Traf7 36
  • 97 (a)
(Monodelphis domestica)
Mammalia TRAF7 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia TRAF7 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Traf7 35
  • 88.59 (n)
  • 97.16 (a)
(Gallus gallus)
Aves TRAF7 35
  • 80.61 (n)
  • 90.84 (a)
TRAF7 36
  • 93 (a)
(Anolis carolinensis)
Reptilia TRAF7 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia rfwd1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9899 35
traf7 35
  • 79.38 (n)
  • 92.19 (a)
(Danio rerio)
Actinopterygii Dr.14712 35
traf7 35
  • 79.08 (n)
  • 90.77 (a)
traf7 36
  • 91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 36
  • 16 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10226 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.662 36
  • 65 (a)
Species with no ortholog for TRAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRAF7 Gene

Gene Tree for TRAF7 (if available)
Gene Tree for TRAF7 (if available)

Paralogs for TRAF7 Gene

Paralogs for TRAF7 Gene

Selected SIMAP similar genes for TRAF7 Gene using alignment to 4 proteins: Pseudogenes for TRAF7 Gene

genes like me logo Genes that share paralogs with TRAF7: view

Variants for TRAF7 Gene

Sequence variations from dbSNP and Humsavar for TRAF7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11383 -- 2,176,378(-) TTCAC(A/T)GTGCT synonymous-codon, reference
rs35810 -- 2,164,323(+) ATGGT(A/T)AAGCG intron-variant
rs35811 -- 2,164,356(+) CTGGT(C/T)GCATG intron-variant
rs35812 -- 2,164,373(+) CGTGT(G/T)AGTGC intron-variant
rs35813 -- 2,164,451(+) TAAGC(A/G)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF7 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2556n71 CNV Loss 21882294
dgv2557n71 CNV Loss 21882294
nsv457349 CNV Loss 19166990
dgv2558n71 CNV Loss 21882294
dgv2562n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv905127 CNV Loss 21882294
nsv905131 CNV Loss 21882294
nsv457351 CNV Loss 19166990
esv2666961 CNV Deletion 23128226
esv2750377 CNV Deletion 23290073
esv25100 CNV Loss 19812545
nsv905132 CNV Loss 21882294
dgv456n67 CNV Gain 20364138
dgv2565n71 CNV Loss 21882294
nsv827511 CNV Gain 20364138

Relevant External Links for TRAF7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF7 Gene

Disorders for TRAF7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRAF7 Gene including...

Search for TRAF7 Gene in MalaCards »

Relevant External Links for TRAF7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRAF7: view

No data available for UniProtKB/Swiss-Prot for TRAF7 Gene

Publications for TRAF7 Gene

  1. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. (PMID: 15001576) Xu L.-G. … Shu H.-B. (J. Biol. Chem. 2004) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PMID: 14743216) Bouwmeester T. … Superti-Furga G. (Nat. Cell Biol. 2004) 3 4
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TRAF7 Gene

Sources for TRAF7 Gene

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