Aliases for TRAF7 Gene
External Ids for TRAF7 Gene
Previous HGNC Symbols for TRAF7 Gene
Previous GeneCards Identifiers for TRAF7 Gene
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
GeneCards Summary for TRAF7 Gene
TRAF7 (TNF Receptor Associated Factor 7) is a Protein Coding gene. Diseases associated with TRAF7 include secretory meningioma. Among its related pathways are Immune System and SMAD Signaling Network. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is FBXW7.
UniProtKB/Swiss-Prot for TRAF7 Gene
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.