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TRAF7 Gene

protein-coding   GIFtS: 50
GCID: GC16P002205

TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase

(Previous names: ring finger and WD repeat domain 1, TNF receptor-associated...)
(Previous symbol: RFWD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase1 2     RING Finger And WD Repeat-Containing Protein 12 3
RFWD11 2 3 5     RING Finger Protein 1192 3
Ring Finger And WD Repeat Domain 11 2     E3 Ubiquitin-Protein Ligase TRAF72
TNF Receptor-Associated Factor 71 3     EC 6.3.2.-3
RNF1192 3     

External Ids:    HGNC: 204561   Entrez Gene: 842312   Ensembl: ENSG000001316537   OMIM: 6066925   UniProtKB: Q6Q0C03   
ORGUL members:         

Export aliases for TRAF7 gene to outside databases

Previous GC identifers: GC16P002125 GC16P002146 GC16P002147 GC16P002132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAF7 Gene:
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for
members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal
cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper)
motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in
self-association and receptor binding.(supplied by OMIM, Apr 2004)

GeneCards Summary for TRAF7 Gene:
TRAF7 (TNF receptor-associated factor 7, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with TRAF7 include secretory meningioma, and meningioma. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates
MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when
overexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRAF7 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRAF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TRAF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002205:  view genomic region     (about GC identifiers)

Start:
2,205,699 bp from pter      End:
2,228,130 bp from pter
Size:
22,432 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRAF7  
Size: 670 amino acids; 74609 Da
Subunit: Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme
Secondary accessions: Q9H073
Alternative splicing: 2 isoforms:  Q6Q0C0-1   Q6Q0C0-2   

Explore the universe of human proteins at neXtProt for TRAF7: NX_Q6Q0C0

Explore proteomics data for TRAF7 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAP3K31
  • Ubiquitinates itself upon phosphorylation1
  • Ubiquitination2 at Lys199, Lys331
  • Modification sites at PhosphoSitePlus

  • See TRAF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115647.2  
    ENSEMBL proteins: 
     ENSP00000318944   ENSP00000457735   ENSP00000456034  

    TRAF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for TRAF7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRAF7
    GenScript Custom Purified and Recombinant Proteins Services for TRAF7
    Novus Biologicals TRAF7 Proteins
    Novus Biologicals TRAF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAF7

    TRAF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRAF7
    OriGene Custom Antibody Services for TRAF7
    Novus Biologicals TRAF7 Antibodies
    Abcam antibodies for TRAF7
    Cloud-Clone Corp. Antibodies for TRAF7
    ThermoFisher Antibodies for TRAF7
    LSBio Antibodies in human, mouse, rat for TRAF7

    TRAF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRAF7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF7
    Cloud-Clone Corp. CLIAs for TRAF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 11):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry Q6Q0C0

    ProtoNet protein and cluster: Q6Q0C0

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Similarity: Belongs to the WD repeat TRAF7 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 TRAF-type zinc finger
    Similarity: Contains 7 WD repeats


    TRAF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF7_HUMAN, Q6Q0C0
    Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates
    MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when
    overexpressed

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14743216
    GO:0005515protein binding IPI14743216
    GO:0008270zinc ion binding NAS14743216
         
    TRAF7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRAF7:
    hsa-mir-484 (MIRT042237), hsa-let-7a-5p (MIRT052480)

    Block miRNA regulation of human, mouse, rat TRAF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAF7 (see all 33):
    hsa-miR-640 hsa-miR-126 hsa-miR-548m hsa-miR-186 hsa-miR-548am hsa-miR-622 hsa-miR-320d hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTRAF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAF7
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRAF7

    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF7 (see all 6)
    OriGene ORF clones in mouse, rat for TRAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF7 (NM_032271)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRAF7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRAF7
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRAF7_HUMAN, Q6Q0C0: Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the
    cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA14743216
    GO:0005886plasma membrane ----
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    TRAF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRAF7
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis


    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF7: 

              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRAF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAF7 (Q6Q0C01, 2, 3 ENSP000003189444) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997591, 2, 3, ENSP000003549274EBI-307556,EBI-307281 MINT-47880 MINT-48476 I2D: score=4 STRING: ENSP00000354927
    PIAS4Q8N2W92, 3MINT-50624 I2D: score=1 
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    CYLDQ9NQC73, ENSP000003089284I2D: score=1 STRING: ENSP00000308928
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IDA14743216
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process IDA15001576
    GO:0016567protein ubiquitination IDA14743216

    TRAF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAF7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAF7 gene (2 alternative transcripts): 
    NM_206835.1  NM_032271.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565383 ENST00000326181(uc002cow.3) ENST00000569686 ENST00000567653
    ENST00000564067 ENST00000567645 ENST00000570169
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRAF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAF7 (see all 33):
    hsa-miR-640 hsa-miR-126 hsa-miR-548m hsa-miR-186 hsa-miR-548am hsa-miR-622 hsa-miR-320d hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTRAF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRAF7
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF7
    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF7 (see all 6)
    OriGene ORF clones in mouse, rat for TRAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF7 (NM_032271)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRAF7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF7
      QuantiTect SYBR Green Assays in human, mouse, rat TRAF7
      QuantiFast Probe-based Assays in human, mouse, rat TRAF7

    Selected AceView cDNA sequences (see all 395):

    BE561046 BQ055478 BQ066455 BQ881204 BM697820 D82151 AI194074 BQ063370 
    NM_206835 BE261119 CB216508 BE675057 BM801226 AI142431 BQ887343 CR595735 
    BQ772178 BU528491 AA101318 AA580497 BU527900 BF341260 AY569455 AA410469 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAF7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                    -           -                       -                             -                                                                 -   
    SP2:                    -           -                 -     -     -                       -                                                                     
    SP3:                                                        -                             -                                                                     
    SP4:                    -           -                       -                                                                                                   
    SP5:                                -                       -                                                                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TRAF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGCGAGC
    TRAF7 Expression
    About this image

    TRAF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAF7 Protein Expression

    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Tissue specificity: Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney,
    liver and placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF7: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF7
    QuantiTect SYBR Green Assays in human, mouse, rat TRAF7
    QuantiFast Probe-based Assays in human, mouse, rat TRAF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRAF7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf71 , 5 TNF receptor-associated factor 71, 5 88.44(n)1
    96.71(a)1
      17 (12.40 cM)5
    2246191  NM_001172113.11  NP_001165584.11 
     245085625 
    chicken
    (Gallus gallus)
    Aves TRAF71 TNF receptor-associated factor 7, E3 ubiquitin protein more 80.61(n)
    90.84(a)
      416555  NM_001012528.1  NP_001012546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF76
    TNF receptor-associated factor 7, E3 ubiquitin pro...
    88(a)
    1 ↔ 1
    GL344485.1(1504-32934)
    African clawed frog
    (Xenopus laevis)
    Amphibia rfwd1-prov2 ring finger and WD repeat domain 1 78.95(n)    BC041725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147122 Transcribed sequence with moderate similarity to protein more 78.51(n)    CK236946.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MET306
    F-box protein containing five copies of the WD40 m...
    16(a)
    1 → many
    IX(268651-270573) YIL046W


    ENSEMBL Gene Tree for TRAF7 (if available)
    TreeFam Gene Tree for TRAF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAF7 gene
    FBXW72  BTRC2  FBXW22  FBXW112  WDR862  ZNF1062  
    1 SIMAP similar gene for TRAF7 using alignment to 4 protein entries:     TRAF7_HUMAN (see all proteins):
    PF20

    TRAF7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRAF7
    PGOHUM00000248766


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAF7 (see all 625)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510506311,2
    C--2207475(+) CCTTTA/GGCAGA 1 -- int10--------
    rs1922929341,2
    --2207514(+) CCTCTA/GTCTGC 1 -- int10--------
    rs1391718301,2
    --2207552(+) CTCCCA/GGGTCA 1 -- int10--------
    rs1452249331,2
    --2207562(+) AGATTC/TGTGTT 1 -- int10--------
    rs1172230881,2
    C,F--2207573(+) CAGCCG/TTCACA 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1174840391,2
    F--2207575(+) GCCGTC/TACACA 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1476500781,2
    --2207652(+) AAGGAA/TTGAGC 1 -- int10--------
    rs1422986531,2
    --2207746(+) CCCGGA/CTTGGC 1 -- int10--------
    rs1454664501,2
    --2207874(+) CTCTCC/TGCCTT 1 -- int10--------
    rs620388411,2
    F--2207940(+) CTTGAC/TGGATC 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TRAF7 (2205699 - 2228130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRAF7 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750377CNV Deletion23290073
    esv2666961CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2562n71CNV Loss21882294
    dgv2545n71CNV Loss21882294
    nsv905131CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    dgv2540n71CNV Loss21882294
    nsv457349CNV Loss19166990

    Human Gene Mutation Database (HGMD): TRAF7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF7
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606692    OMIM disorders: --

    3 diseases for TRAF7:    
    About MalaCards
    secretory meningioma    meningioma    neuronitis


    TRAF7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRAF7
    Human Genome Epidemiology (HuGE) Navigator: TRAF7 (1 document)

    Export disorders for TRAF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAF7 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TRAF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. (PubMed id 15001576)1, 2, 3 Xu L.-G.... Shu H.-B. (J. Biol. Chem. 2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. (PubMed id 23348505)1 Clark V.E....GA1nel M. (Science 2013)
    7. Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations. (PubMed id 23404370)1 Reuss D.E....von Deimling A. (Acta Neuropathol. 2013)
    8. Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer. (PubMed id 23128672)1 Wang L....Liu S. (Oncol. Rep. 2013)
    9. The seventh ring: exploring TRAF7 functions. (PubMed id 22105767)1 Zotti T....Stilo R. (J. Cell. Physiol. 2012)
    10. Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFI+-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein. (PubMed id 22219201)1 Scudiero I....Stilo R. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84231 HGNC: 20456 AceView: TRAF7 Ensembl:ENSG00000131653 euGenes: HUgn84231
    ECgene: TRAF7 H-InvDB: TRAF7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRAF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRAF7 gene:
    Search GeneIP for patents involving TRAF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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