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Aliases for TRAF7 Gene

Aliases for TRAF7 Gene

  • TNF Receptor Associated Factor 7 2 3 5
  • TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase 2 3
  • RING Finger And WD Repeat-Containing Protein 1 3 4
  • RING-Type E3 Ubiquitin Transferase TRAF7 3 4
  • Ring Finger And WD Repeat Domain 1 2 3
  • RING Finger Protein 119 3 4
  • RNF119 3 4
  • RFWD1 3 4
  • E3 Ubiquitin-Protein Ligase TRAF7 3
  • TNF Receptor-Associated Factor 7 4
  • EC 4

External Ids for TRAF7 Gene

Previous HGNC Symbols for TRAF7 Gene

  • RFWD1

Previous GeneCards Identifiers for TRAF7 Gene

  • GC16P002125
  • GC16P002146
  • GC16P002147
  • GC16P002205
  • GC16P002132
  • GC16P002156
  • GC16P002165
  • GC16P002188

Summaries for TRAF7 Gene

Entrez Gene Summary for TRAF7 Gene

  • Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

GeneCards Summary for TRAF7 Gene

TRAF7 (TNF Receptor Associated Factor 7) is a Protein Coding gene. Diseases associated with TRAF7 include Secretory Meningioma and Meningioma, Familial. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ZNF106.

UniProtKB/Swiss-Prot for TRAF7 Gene

  • E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.

Additional gene information for TRAF7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF7 Gene

Genomics for TRAF7 Gene

GeneHancer (GH) Regulatory Elements for TRAF7 Gene

Promoters and enhancers for TRAF7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 594.7 +0.1 92 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002156 GC16M002158 RAB26 ENSG00000261505 ENSG00000260051 SRRM2
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 47.9 -844.9 -844944 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 44.3 +866.6 866605 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 43.9 -191.5 -191476 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001962 GC16M001963 GC16M001965 GC16M001966 GC16P001995 GC16P002197
GH16I002266 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.1 +112.5 112514 3.2 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 RNPS1 LOC106660606 GC16M002267 GC16M002266 ZNF263 ENSG00000260051 ENSG00000261505 E4F1 AMDHD2 TSC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAF7 gene promoter:

Genomic Locations for TRAF7 Gene

Genomic Locations for TRAF7 Gene
22,432 bases
Plus strand

Genomic View for TRAF7 Gene

Genes around TRAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF7 Gene

Proteins for TRAF7 Gene

  • Protein details for TRAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRAF7
    Protein Accession:
    Secondary Accessions:
    • Q9H073

    Protein attributes for TRAF7 Gene

    670 amino acids
    Molecular mass:
    74609 Da
    Quaternary structure:
    • Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme.

    Alternative splice isoforms for TRAF7 Gene


neXtProt entry for TRAF7 Gene

Post-translational modifications for TRAF7 Gene

Other Protein References for TRAF7 Gene

No data available for DME Specific Peptides for TRAF7 Gene

Domains & Families for TRAF7 Gene

Gene Families for TRAF7 Gene

Suggested Antigen Peptide Sequences for TRAF7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat TRAF7 family.
  • Belongs to the WD repeat TRAF7 family.
genes like me logo Genes that share domains with TRAF7: view

Function for TRAF7 Gene

Molecular function for TRAF7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.

Enzyme Numbers (IUBMB) for TRAF7 Gene

Phenotypes From GWAS Catalog for TRAF7 Gene

Gene Ontology (GO) - Molecular Function for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14743216
GO:0005515 protein binding IPI 14743216
GO:0008270 zinc ion binding NAS 14743216
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRAF7: view

Phenotypes for TRAF7 Gene

genes like me logo Genes that share phenotypes with TRAF7: view

miRNA for TRAF7 Gene

miRTarBase miRNAs that target TRAF7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRAF7 Gene

Localization for TRAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF7 Gene

Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF7 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14743216
GO:0005886 plasma membrane IDA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TRAF7: view

Pathways & Interactions for TRAF7 Gene

genes like me logo Genes that share pathways with TRAF7: view

UniProtKB/Swiss-Prot Q6Q0C0-TRAF7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRAF7 Gene


Gene Ontology (GO) - Biological Process for TRAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000185 activation of MAPKKK activity IDA 14743216
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IDA 15001576
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRAF7: view

Drugs & Compounds for TRAF7 Gene

No Compound Related Data Available

Transcripts for TRAF7 Gene

Unigene Clusters for TRAF7 Gene

TNF receptor-associated factor 7, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - -
SP7: -
SP9: -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22

Relevant External Links for TRAF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF7 Gene

Protein differential expression in normal tissues from HIPED for TRAF7 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.4), Peripheral blood mononuclear cells (26.0), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF7 Gene

Protein tissue co-expression partners for TRAF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAF7 Gene:


SOURCE GeneReport for Unigene cluster for TRAF7 Gene:


mRNA Expression by UniProt/SwissProt for TRAF7 Gene:

Tissue specificity: Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta.

Evidence on tissue expression from TISSUES for TRAF7 Gene

  • Nervous system(3.7)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with TRAF7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF7 Gene

Orthologs for TRAF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAF7 33 34
  • 99.55 (n)
(Monodelphis domestica)
Mammalia TRAF7 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia TRAF7 34
  • 95 (a)
(Bos Taurus)
Mammalia TRAF7 33 34
  • 92.18 (n)
(Canis familiaris)
Mammalia TRAF7 33 34
  • 91.89 (n)
(Rattus norvegicus)
Mammalia Traf7 33
  • 88.59 (n)
(Mus musculus)
Mammalia Traf7 33 16 34
  • 88.44 (n)
(Gallus gallus)
Aves TRAF7 33 34
  • 80.61 (n)
(Anolis carolinensis)
Reptilia TRAF7 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia traf7 33
  • 79.38 (n)
Str.9899 33
African clawed frog
(Xenopus laevis)
Amphibia rfwd1-prov 33
(Danio rerio)
Actinopterygii traf7 33 34
  • 79.08 (n)
Dr.14712 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET30 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.662 34
  • 65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10226 33
Species where no ortholog for TRAF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRAF7 Gene

Gene Tree for TRAF7 (if available)
Gene Tree for TRAF7 (if available)

Paralogs for TRAF7 Gene

Paralogs for TRAF7 Gene

(1) SIMAP similar genes for TRAF7 Gene using alignment to 4 proteins: Pseudogenes for TRAF7 Gene

genes like me logo Genes that share paralogs with TRAF7: view

Variants for TRAF7 Gene

Sequence variations from dbSNP and Humsavar for TRAF7 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000083182 -- 2,157,884(+) GCC/ intron_variant
rs1000131982 -- 2,170,964(+) G/A intron_variant
rs1000372390 -- 2,154,145(+) C/G/T upstream_transcript_variant
rs1000505285 -- 2,155,626(+) T/C upstream_transcript_variant
rs1000559626 -- 2,171,990(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF7 Gene

Variant ID Type Subtype PubMed ID
dgv456n67 CNV gain 20364138
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv25100 CNV loss 19812545
esv2666961 CNV deletion 23128226
esv2750377 CNV deletion 23290073
esv3637629 CNV loss 21293372
nsv1052260 CNV gain 25217958
nsv457349 CNV loss 19166990
nsv457351 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571190 CNV loss 21841781
nsv827511 CNV gain 20364138
nsv952902 CNV deletion 24416366

Variation tolerance for TRAF7 Gene

Residual Variation Intolerance Score: 5.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAF7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF7 Gene

Disorders for TRAF7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAF7 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
secretory meningioma
  • meningioma
meningioma, familial
  • meningioma, familial, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search TRAF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAF7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF7 Gene

Publications for TRAF7 Gene

  1. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. (PMID: 15001576) Xu LG … Shu HB (The Journal of biological chemistry 2004) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
  4. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PMID: 14743216) Bouwmeester T … Superti-Furga G (Nature cell biology 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRAF7 Gene

Sources for TRAF7 Gene