Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF7 Gene

protein-coding   GIFtS: 50
GCID: GC16P002205

TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase

(Previous names: ring finger and WD repeat domain 1, TNF receptor-associated...)
(Previous symbol: RFWD1)
  Search for TRAF7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 7, E3 Ubiquitin Protein Ligase1 2     RING Finger And WD Repeat-Containing Protein 12 3
RFWD11 2 3 5     RING Finger Protein 1192 3
Ring Finger And WD Repeat Domain 11 2     E3 Ubiquitin-Protein Ligase TRAF72
TNF Receptor-Associated Factor 71 3     EC 6.3.2.-3
RNF1192 3     

External Ids:    HGNC: 204561   Entrez Gene: 842312   Ensembl: ENSG000001316537   OMIM: 6066925   UniProtKB: Q6Q0C03   

Export aliases for TRAF7 gene to outside databases

Previous GC identifers: GC16P002125 GC16P002146 GC16P002147 GC16P002132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF7 Gene:
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for
members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal
cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper)
motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in
self-association and receptor binding.(supplied by OMIM, Apr 2004)

GeneCards Summary for TRAF7 Gene: 
TRAF7 (TNF receptor-associated factor 7, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is FBXW7.

UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates
MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when
overexpressed




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF7 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRAF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TRAF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002205:  view genomic region     (about GC identifiers)

Start:
2,205,699 bp from pter      End:
2,228,130 bp from pter
Size:
22,432 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRAF7  
Size: 670 amino acids; 74609 Da
Subunit: Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme
Subcellular location: Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the
cytoplasm
Secondary accessions: Q9H073
Alternative splicing: 2 isoforms:  Q6Q0C0-1   Q6Q0C0-2   

Explore the universe of human proteins at neXtProt for TRAF7: NX_Q6Q0C0

Explore proteomics data for TRAF7 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MAP3K3
  • UniProtKB: Ubiquitinates itself upon phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6Q0C0

  • TRAF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAF7 Protein Expression
    REFSEQ proteins: NP_115647.2  
    ENSEMBL proteins: 
     ENSP00000318944   ENSP00000457735   ENSP00000456034  

    Human Recombinant Protein Products for TRAF7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TRAF7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRAF7
    GenScript Custom Purified and Recombinant Proteins Services for TRAF7
    Novus Biologicals TRAF7 Proteins
    Novus Biologicals TRAF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAF7 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA14743216
    GO:0005886plasma membrane IDA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    TRAF7 for ontologies           About GeneDecksing



    TRAF7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRAF7
    GenScript Custom Superior Antibodies Services for TRAF7
    Novus Biologicals TRAF7 Antibodies
    Abcam antibodies for TRAF7
    Cloud-Clone Corp. Antibodies for TRAF7 
    ThermoFisher Antibodies for TRAF7
    LSBio Antibodies in human, mouse, rat for TRAF7 

    Assay Products for TRAF7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRAF7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF7 
    Cloud-Clone Corp. CLIAs for TRAF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers
    WDR: WD repeat domain containing

    5/12 InterPro protein domains (see all 12):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat

    Graphical View of Domain Structure for InterPro Entry Q6Q0C0

    ProtoNet protein and cluster: Q6Q0C0

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Similarity: Belongs to the WD repeat TRAF7 family
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 TRAF-type zinc finger
    Similarity: Contains 7 WD repeats


    TRAF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF7_HUMAN, Q6Q0C0
    Function: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates
    MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when
    overexpressed

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14743216
    GO:0005515protein binding IPI14743216
    GO:0008270zinc ion binding NAS14743216
         
    TRAF7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF7
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF7 (see all 33):
    hsa-miR-640 hsa-miR-126 hsa-miR-548m hsa-miR-186 hsa-miR-548am hsa-miR-622 hsa-miR-320d hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTRAF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRAF7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRAF7
    Sirion Biotech Customized adenovirus for overexpression of TRAF7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRAF7 (see all 7)
    OriGene ORF clones in mouse, rat for TRAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF7 (NM_032271)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRAF7
    Sirion Biotech Customized lentivirus for stable overexpression of TRAF7 
                         Customized lentivirus expression plasmids for stable overexpression of TRAF7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRAF7
    Search LifeMap BioReagents cell lines for TRAF7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/17 Interacting proteins for TRAF7 (Q6Q0C01, 2, 3 ENSP000003189444) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997591, 2, 3, ENSP000003549274EBI-307556,EBI-307281 MINT-47880 MINT-48476 I2D: score=4 STRING: ENSP00000354927
    PIAS4Q8N2W92, 3MINT-50624 I2D: score=1 
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    CYLDQ9NQC73, ENSP000003089284I2D: score=1 STRING: ENSP00000308928
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000185activation of MAPKKK activity IDA14743216
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IDA15001576
    GO:0016567protein ubiquitination IDA14743216

    TRAF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF7

    Search CenterWatch for drugs/clinical trials and news about TRAF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF7 gene (2 alternative transcripts): 
    NM_206835.1  NM_032271.2  

    Unigene Cluster for TRAF7:

    TNF receptor-associated factor 7, E3 ubiquitin protein ligase
    Hs.713632  [show with all ESTs]
    Unigene Representative Sequence: NM_032271
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565383 ENST00000326181(uc002cow.3) ENST00000569686 ENST00000567653
    ENST00000564067 ENST00000567645 ENST00000570169
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF7
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF7 (see all 33):
    hsa-miR-640 hsa-miR-126 hsa-miR-548m hsa-miR-186 hsa-miR-548am hsa-miR-622 hsa-miR-320d hsa-miR-619
    SwitchGear 3'UTR luciferase reporter plasmidTRAF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRAF7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF7
    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF7 (see all 7)
    OriGene ORF clones in mouse, rat for TRAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF7 (NM_032271)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF7
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRAF7
    Sirion Biotech Customized lentivirus for stable overexpression of TRAF7 
                         Customized lentivirus expression plasmids for stable overexpression of TRAF7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF7

    Additional mRNA sequence: 

    AK090624.1 AL136921.1 AY569455.1 BC024267.1 

    14 DOTS entries:

    DT.95217638  DT.456198  DT.97860219  DT.91760365  DT.97860218  DT.86854340  DT.99942185  DT.100792684 
    DT.91760368  DT.211798  DT.91760351  DT.91760366  DT.92034414  DT.97824315 

    24/395 AceView cDNA sequences (see all 395):

    BM682540 AI146391 BE614981 BQ881204 D82151 BM697820 BQ058143 BU149357 
    AK090624 BI831197 NM_206835 BE788494 BQ775071 BM709762 BE255763 D82459 
    BQ688339 AI754508 CR595735 BQ054627 BG576831 BQ016276 CO247399 BU521916 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                    -           -                       -                             -                                                                 -   
    SP2:                    -           -                 -     -     -                       -                                                                     
    SP3:                                                        -                             -                                                                     
    SP4:                    -           -                       -                                                                                                   
    SP5:                                -                       -                                                                                                   

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TRAF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGGCGAGC
    TRAF7 Expression
    About this image


    See TRAF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF7

    SOURCE GeneReport for Unigene cluster: Hs.713632

    UniProtKB/Swiss-Prot: TRAF7_HUMAN, Q6Q0C0
    Tissue specificity: Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney,
    liver and placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF7: 
              TNF Ligands & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TRAF7 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf71 , 5 TNF receptor-associated factor 71, 5 88.44(n)1
    96.71(a)1
      17 (12.40 cM)5
    2246191  NM_001172113.11  NP_001165584.11 
     245085625 
    chicken
    (Gallus gallus)
    Aves TRAF71 TNF receptor-associated factor 7 80.61(n)
    90.84(a)
      416555  NM_001012528.1  NP_001012546.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF76
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL344485.1(1504-32934)
    African clawed frog
    (Xenopus laevis)
    Amphibia rfwd1-prov2 ring finger and WD repeat domain 1 78.95(n)    BC041725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147122 Transcribed sequence with moderate similarity to protein more 78.51(n)    CK236946.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MET306
    F-box protein containing five copies of the WD40 m...
    15(a)
    1 → many
    IX(268651-270573)


    ENSEMBL Gene Tree for TRAF7 (if available)
    TreeFam Gene Tree for TRAF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF7 gene
    FBXW72  BTRC2  FBXW22  FBXW112  WDR862  ZNF1062  
    1 SIMAP similar gene for TRAF7 using alignment to 4 protein entries:     TRAF7_HUMAN (see all proteins):
    PF20

    TRAF7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRAF7
    PGOHUM00000248766


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/625 SNPs in TRAF7 are shown (see all 625)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510506311,2
    C--2207475(+) CCTTTA/GGCAGA 1 -- int10--------
    rs1922929341,2
    --2207514(+) CCTCTA/GTCTGC 1 -- int10--------
    rs1391718301,2
    --2207552(+) CTCCCA/GGGTCA 1 -- int10--------
    rs1452249331,2
    --2207562(+) AGATTC/TGTGTT 1 -- int10--------
    rs1172230881,2
    C,F--2207573(+) CAGCCG/TTCACA 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1174840391,2
    F--2207575(+) GCCGTC/TACACA 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1476500781,2
    --2207652(+) AAGGAA/TTGAGC 1 -- int10--------
    rs1422986531,2
    --2207746(+) CCCGGA/CTTGGC 1 -- int10--------
    rs1454664501,2
    --2207874(+) CTCTCC/TGCCTT 1 -- int10--------
    rs620388411,2
    F--2207940(+) CTTGAC/TGGATC 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TRAF7 (2205699 - 2228130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for TRAF7 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750377CNV Deletion23290073
    esv2666961CNV Deletion23128226
    esv2422427CNV Duplication17116639
    dgv2562n71CNV Loss21882294
    dgv2545n71CNV Loss21882294
    nsv905131CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv457351CNV Loss19166990
    dgv2540n71CNV Loss21882294
    nsv457349CNV Loss19166990


    Human Gene Mutation Database (HGMD): TRAF7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF7
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRAF7 for disorders           About MalaCards
    OMIM gene information: 606692    OMIM disorders: --


    TRAF7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRAF7
    Human Genome Epidemiology (HuGE) Navigator: TRAF7 (1 document)

    Export disorders for TRAF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF7 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TRAF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. (PubMed id 15001576)1, 2, 3 Xu L.-G.... Shu H.-B. (2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    4. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (2004)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. Genomic analysis of non-NF2 meningiomas reveals mutati ons in TRAF7, KLF4, AKT1, and SMO. (PubMed id 23348505)1 Clark V.E....Gunel M. (2013)
    7. Secretory meningiomas are defined by combined KLF4 K40 9Q and TRAF7 mutations. (PubMed id 23404370)1 Reuss D.E....von Deimling A. (2013)
    8. The seventh ring: exploring TRAF7 functions. (PubMed id 22105767)1 Zotti T....Stilo R. (2012)
    9. Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFa-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein. (PubMed id 22219201)1 Scudiero I....Stilo R. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84231 HGNC: 20456 AceView: TRAF7 Ensembl:ENSG00000131653 euGenes: HUgn84231
    ECgene: TRAF7 H-InvDB: TRAF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAF7 gene:
    Search GeneIP for patents involving TRAF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRAF7  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TRAF7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRAF7  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRAF7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRAF7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRAF7   OriGene Custom Protein Services for TRAF7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRAF7
     QIAGEN SeqTarget long-range PCR primers for resequencing TRAF7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF7
     GenScript Custom Purified and Recombinant Proteins Services for TRAF7 GenScript cDNA clones with any tag delivered in your preferred vector for TRAF7
     GenScript Custom Assay Services for TRAF7 GenScript Custom Superior Antibodies Services for TRAF7
     GenScript Custom overexpressing Cell Line Services for TRAF7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRAF7 promoter
     Search Chromatin IP Primers for TRAF7
     RT2 qPCR Primer Assay in human, mouse, rat TRAF7
     Search GNC Networks for TRAF7
     SABiosciences PCR Arrays including human, mouse, rat TRAF7
     Search Tocris compounds for TRAF7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRAF7 antibodies
     TRAF7 proteins
     TRAF7 lysates
     Antibodies for TRAF7
     See all of Abcam's Antibodies, Kits and Proteins for TRAF7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRAF7
     Antibodies for TRAF7
     ELISAs for TRAF7
     CLIAs for TRAF7
     Search LifeMap BioReagents cell lines for TRAF7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF7
     SwitchGear 3'UTR luciferase reporter plasmids for TRAF7
     Browse SwitchGear Promoter luciferase reporter plasmids for TRAF7
     ThermoFisher Antibodies for TRAF7
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRAF7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAF7
    Customized:
     lentivirus for stable overexpression of TRAF7
     lentivirus expression plasmids for stable overexpression of TRAF7
     adenovirus for overexpression of TRAF7
     LSBio Antibodies in human, mouse, rat for TRAF7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRAF7 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4