Aliases for TRAF6 Gene
Aliases for TRAF6 Gene
External Ids for TRAF6 Gene
- HGNC: 12036
- Entrez Gene: 7189
- Ensembl: ENSG00000175104
- OMIM: 602355
- UniProtKB: Q9Y4K3
Previous GeneCards Identifiers for TRAF6 Gene
- GC11M038067
- GC11M037188
- GC11M036549
- GC11M036475
- GC11M036212
Summaries for TRAF6 Gene
-
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
GeneCards Summary for TRAF6 Gene
TRAF6 (TNF Receptor Associated Factor 6) is a Protein Coding gene. Diseases associated with TRAF6 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Incontinentia Pigmenti. Among its related pathways are TRAF Pathway and Bacterial infections in CF airways. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRAF5.
UniProtKB/Swiss-Prot for TRAF6 Gene
-
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF6 Gene
Genomics for TRAF6 Gene
Regulatory Elements for TRAF6 Gene
Enhancers for TRAF6 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G036487 | 1.4 | Ensembl ENCODE | 17 | +22.2 | 22240 | 1.8 | HNRNPUL1 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 | PRR5L TRAF6 RAG1 COMMD9 ENSG00000255060 GC11M036483 |
| GH11G036541 | 1 | Ensembl ENCODE | 12 | -30.9 | -30888 | 0.4 | CTCF TFAP4 PKNOX1 ATF1 USF1 TBL1XR1 SAP130 RAD21 FOXK2 IKZF2 | RAG1 TRAF6 C11orf74 RAG2 GC11M036546 |
| GH11G036626 | 1 | ENCODE dbSUPER | 10.5 | -117.4 | -117386 | 2.4 | PKNOX1 FEZF1 ZIC2 RAD21 CTBP1 SCRT2 ZBTB20 TCF7L2 SCRT1 GFI1B | RAG2 C11orf74 TRAF6 RAG1 GC11M036597 GC11M036644 |
| GH11G036469 | 0.8 | ENCODE | 10.9 | +40.2 | 40246 | 2.0 | CTCF ZBTB21 INSM2 FEZF1 ZNF101 HIC1 ZNF366 SCRT2 ZNF600 KLF8 | PRR5L ENSG00000255060 RAG1 TRAF6 COMMD9 GC11M036483 GC11P036439 |
| GH11G036292 | 0.8 | Ensembl | 10.6 | +217.6 | 217613 | 0.2 | CTCF ESRRA CBX3 PTBP1 CHD4 CEBPG RAD21 CHAMP1 ARID3A ADNP | RAG1 TRAF6 ENSG00000255060 COMMD9 PRR5L |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TRAF6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TRAF6 gene promoter:
Regulatory Element Products
Genomic Location for TRAF6 Gene
- Chromosome:
- 11
- Start:
- 36,483,767 bp from pter
- End:
- 36,510,313 bp from pter
- Size:
- 26,547 bases
- Orientation:
- Minus strand
Genomic View for TRAF6 Gene
Genes around TRAF6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p12 by Ensembl
- 11p12 by Entrez Gene
- 11p12 by HGNC
TRAF6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRAF6 Gene
Proteins for TRAF6 Gene
-
Protein details for TRAF6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y4K3-TRAF6_HUMAN
- Recommended name:
- TNF receptor-associated factor 6
- Protein Accession:
- Q9Y4K3
- A6NKI7
- A8KAB3
- D3DR16
- Q8NEH5
Protein attributes for TRAF6 Gene
- Size:
- 522 amino acids
- Molecular mass:
- 59573 Da
- Quaternary structure:
-
- Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1. Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with TRAF3IP2. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989).
Protein Expression for TRAF6 Gene
Post-translational modifications for TRAF6 Gene
- Polyubiquitinated on Lys-124; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This Lys-63 site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage (PubMed:25861989).
- Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TRAF6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TRAF6 (TRAF-6)
- Cell Signaling Technology (CST) Antibodies for TRAF6 (TRAF6)
-
Custom Antibody ServicesOriGene Antibodies for TRAF6
- Novus Biologicals Antibodies for TRAF6
-
Cloud-Clone Corp. Antibodies for TRAF6
- Invitrogen Antibodies for TRAF6
- antibodies-online Antibodies for TRAF6: See all 140
- GeneTex TRAF6 antibody for TRAF6
-
Custom Antibody ServicesProSci Antibodies for TRAF6
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRAF6
Protein Products
-
OriGene Purified Proteins for TRAF6
- Search Origene for MassSpec and Protein Over-expression Lysates for TRAF6
- Origene Custom Protein Services for TRAF6
-
Cloud-Clone Corp. Proteins for TRAF6
- antibodies-online Proteins for TRAF6: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TRAF6
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for TRAF6 (TRAF-6)
-
Cloud-Clone Corp. Assay Kits for TRAF6
- antibodies-online Kits for TRAF6: See all 10
No data available for DME Specific Peptides for TRAF6 Gene
Domains & Families for TRAF6 Gene
Gene Families for TRAF6 Gene
Protein Domains for TRAF6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRAF6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y4K3UniProtKB/Swiss-Prot:
TRAF6_HUMAN :- The coiled coil domain mediates homo- and hetero-oligomerization.
- Belongs to the TNF receptor-associated factor family. A subfamily.
- Domain:
-
- The coiled coil domain mediates homo- and hetero-oligomerization.
- The MATH/TRAF domain binds to receptor cytoplasmic domains.
- Family:
-
- Belongs to the TNF receptor-associated factor family. A subfamily.
Function for TRAF6 Gene
Molecular function for TRAF6 Gene
- GENATLAS Biochemistry:
- tumor necrosis factor (TNF)-receptor-associated factor 6,cytoplasmic,involved in the activation of NFKB by TNFRSFs,associating with IRAK1 after stimulation by IL1B,also associating with TNFRSF11 and SRC and,in turn activating the kinase activity of SRC
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.
Enzyme Numbers (IUBMB) for TRAF6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005164 | tumor necrosis factor receptor binding | IPI | 11728344 |
| GO:0005515 | protein binding | IPI | 10094049 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for TRAF6 Gene
- MGI mutant phenotypes for TRAF6:
-
inferred from 6 alleles
- mortality/aging
- cellular phenotype
- growth/size/body region phenotype
- immune system phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- pigmentation phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for TRAF6:
-
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Increased G1 DNA content
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell death HMECs cells
- Increased Nanog expression
- Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Models for TRAF6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAF6
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAF6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAF6 gene
- Search ViGene Biosciences for TRAF6
CRISPR Products
-
OriGene CRISPR knockouts for TRAF6
-
Applied Biological Materials CRISPR for TRAF6
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAF6
- GenScript: Design CRISPR guide RNA sequences for TRAF6
miRNA for TRAF6 Gene
- miRTarBase miRNAs that target TRAF6
-
- hsa-mir-146a-5p (MIRT000711)
- hsa-mir-146b-5p (MIRT005394)
- hsa-mir-1253 (MIRT130042)
- hsa-mir-5197-3p (MIRT130055)
- hsa-mir-5692a (MIRT383128)
- hsa-mir-410-3p (MIRT383129)
- hsa-mir-125a-5p (MIRT438046)
- hsa-mir-374a-5p (MIRT439396)
- hsa-mir-1304-5p (MIRT449126)
- hsa-mir-6083 (MIRT449127)
- hsa-mir-6869-5p (MIRT449128)
- hsa-mir-6765-5p (MIRT449129)
- hsa-mir-190a-3p (MIRT449130)
- hsa-mir-633 (MIRT449131)
- hsa-mir-1827 (MIRT449132)
- hsa-mir-3163 (MIRT449133)
- hsa-mir-3202 (MIRT482792)
- hsa-mir-6763-5p (MIRT482793)
- hsa-mir-6748-5p (MIRT482794)
- hsa-mir-3150a-3p (MIRT482795)
- hsa-mir-491-5p (MIRT482796)
- hsa-mir-6769b-5p (MIRT482797)
- hsa-mir-6769a-5p (MIRT482798)
- hsa-mir-92a-2-5p (MIRT482799)
- hsa-mir-4483 (MIRT482800)
- hsa-mir-1293 (MIRT482801)
- hsa-mir-6766-5p (MIRT482802)
- hsa-mir-6745 (MIRT482803)
- hsa-mir-6756-5p (MIRT482804)
- hsa-mir-363-5p (MIRT482805)
- hsa-mir-6825-5p (MIRT482806)
- hsa-mir-939-5p (MIRT482807)
- hsa-mir-1343-5p (MIRT482808)
- hsa-mir-3175 (MIRT482809)
- hsa-mir-6883-5p (MIRT482810)
- hsa-mir-6785-5p (MIRT482811)
- hsa-mir-4728-5p (MIRT482812)
- hsa-mir-6878-5p (MIRT482813)
- hsa-mir-149-3p (MIRT482814)
- hsa-mir-6797-5p (MIRT482815)
- hsa-mir-1249-5p (MIRT482816)
- hsa-mir-5703 (MIRT482817)
- hsa-mir-4516 (MIRT482818)
- hsa-mir-4434 (MIRT482819)
- hsa-mir-6133 (MIRT482820)
- hsa-mir-6130 (MIRT482821)
- hsa-mir-6127 (MIRT482822)
- hsa-mir-6129 (MIRT482823)
- hsa-mir-4510 (MIRT482824)
- hsa-mir-4419a (MIRT482825)
- hsa-mir-6760-5p (MIRT482826)
- hsa-mir-6516-5p (MIRT565226)
- hsa-mir-455-3p (MIRT565227)
- hsa-mir-6807-5p (MIRT565228)
- hsa-mir-7847-3p (MIRT565229)
- hsa-mir-6880-5p (MIRT565230)
- hsa-mir-6799-5p (MIRT565231)
- hsa-mir-6851-5p (MIRT565232)
- hsa-mir-3689d (MIRT565233)
- hsa-mir-6499-3p (MIRT565234)
- hsa-mir-6086 (MIRT565235)
- hsa-mir-377-5p (MIRT565236)
- hsa-mir-6134 (MIRT565237)
- hsa-mir-1233-3p (MIRT565238)
- hsa-mir-1225-3p (MIRT565239)
- hsa-mir-1247-3p (MIRT565240)
- hsa-mir-3940-3p (MIRT565241)
miRNA Products
- Search ViGene Biosciences for TRAF6
Inhibitory RNA Products
- Origene shRNA products in human, mouse, rat for TRAF6
- Browse OriGene Inhibitory RNA Products For TRAF6
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAF6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TRAF6
- VectorBuilder custom plasmid, inducible vectors for TRAF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAF6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TRAF6
-
ViGene Biosciences adenoviral particle packaged cDNA for TRAF6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRAF6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAF6 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF6 Gene
Localization for TRAF6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRAF6 Gene
- Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
| mitochondrion | 3 |
| extracellular | 2 |
| cytoskeleton | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 18093978 |
| GO:0005737 | cytoplasm | IDA,IEA | 16378096 |
| GO:0005811 | lipid particle | ISS | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for TRAF6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | p75 NTR receptor-mediated signalling | ||
| 3 | Toll-Like receptor Signaling Pathways | ||
| 4 | RANK Signaling in Osteoclasts |
.92
|
.38
|
| 5 | Diseases associated with the TLR signaling cascade | ||
Pathways by source for TRAF6 Gene
1 GeneTex pathway for TRAF6 Gene
2 Cell Signaling Technology pathways for TRAF6 Gene
30 BioSystems pathways for TRAF6 Gene
22 KEGG pathways for TRAF6 Gene
17 GeneGo (Thomson Reuters) pathways for TRAF6 Gene
7 R&D Systems pathways for TRAF6 Gene
21 Qiagen pathways for TRAF6 Gene
UniProtKB/Swiss-Prot Q9Y4K3-TRAF6_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRAF6 Gene
Selected Interacting proteins:
Q9Y4K3-TRAF6_HUMAN
ENSP00000337853
for TRAF6 Gene via
MINT
STRING
IID
UniProtKB
SIGNOR curated interactions for TRAF6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IMP | 18093978 |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0000209 | protein polyubiquitination | IDA | 15125833 |
| GO:0001503 | ossification | IEA | -- |
| GO:0001843 | neural tube closure | IEA | -- |
Transcripts for TRAF6 Gene
mRNA/cDNA for TRAF6 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (124) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRAF6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRAF6
-
Applied Biological Materials CRISPR for TRAF6
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRAF6
- GenScript: Design CRISPR guide RNA sequences for TRAF6
miRNA Products
- Search ViGene Biosciences for TRAF6
Inhibitory RNA Products
- Origene shRNA products in human, mouse, rat for TRAF6
- Browse OriGene Inhibitory RNA Products For TRAF6
-
ViGene Biosciences ready-to-package AAV shRNAs for TRAF6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TRAF6
- VectorBuilder custom plasmid, inducible vectors for TRAF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAF6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | - |
Expression for TRAF6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Dental Papilla Cells Dental Papilla
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Blood (Hematopoietic System)
- Osteoclast Precursor Cells Hematopoietic Bone Marrow
-
Bone (Muscoskeletal System)
- Osteoclast Precursor Cells Hematopoietic Bone Marrow
-
Pancreas (Endocrine System)
This gene is overexpressed in Peripheral blood mononuclear cells (14.9), Heart (7.5), and Testis (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF6 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TRAF6 Gene:
TRAF6SOURCE GeneReport for Unigene cluster for TRAF6 Gene:
Hs.444172mRNA Expression by UniProt/SwissProt for TRAF6 Gene:
Q9Y4K3-TRAF6_HUMAN
Tissue specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for TRAF6 Gene
- Blood(2.6)
- Bone(2.3)
- Spleen(2.3)
- Bone marrow(2.1)
- Lung(2)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF6 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- nervous
- skeleton
Organs:
Head and neck:
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- nose
- scalp
- skull
- tooth
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- hair
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for TRAF6
-
OriGene qPCR primer pairs and template standards for TRAF6
No data available for mRNA differential expression in normal tissues for TRAF6 Gene
Orthologs for TRAF6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TRAF6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TRAF6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TRAF6 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Traf6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Traf6 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRAF6 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TRAF6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TRAF6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TRAF6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | traf6 34 |
|
||
| Str.8271 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14682 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | traf6 34 35 |
|
||
| wufi15f02 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1398 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003004 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Traf6 34 |
|
||
| Traf-like 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | trf-1 35 |
|
ManyToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany |
- Species where no ortholog for TRAF6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRAF6 Gene
Variants for TRAF6 Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043685 | -- | 36,495,108(+) | ACAAC(G/T)AATTT | intron-variant, utr-variant-3-prime | |
| rs1000170608 | -- | 36,508,679(+) | TAGAA(A/G)CAGAA | intron-variant, upstream-variant-2KB | |
| rs1000187526 | -- | 36,508,872(+) | AATCT(A/C)AGTGT | intron-variant, upstream-variant-2KB | |
| rs1000271506 | -- | 36,502,393(+) | ACCAT(C/T)ATGGT | intron-variant | |
| rs1000473497 | -- | 36,495,766(+) | GCATG(C/T)CTGTA | intron-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1601897 | CNV | insertion | 17803354 |
| esv1648317 | CNV | insertion | 17803354 |
| esv2422305 | CNV | duplication | 17116639 |
| esv2678965 | CNV | deletion | 23128226 |
| esv3416520 | CNV | insertion | 20981092 |
| esv3625956 | CNV | loss | 21293372 |
| nsv1042014 | CNV | loss | 25217958 |
| nsv467791 | CNV | gain | 19166990 |
| nsv554003 | CNV | gain | 21841781 |
| nsv975903 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TRAF6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF6 Gene
Disorders for TRAF6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant |
|
|
| incontinentia pigmenti |
|
|
| immunodeficiency with hyper-igm, type 3 |
|
|
| ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive |
|
|
| toxoplasmosis |
|
|
Search TRAF6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TRAF6
No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF6 Gene
Publications for TRAF6 Gene
- TRAF6 is a signal transducer for interleukin-1. (PMID: 8837778) Cao Z. … Goeddel D.V. (Nature 1996) 2 3 4 22 64
- NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. (PMID: 20079715) Zhou L. … Huo K. (Biochem. Biophys. Res. Commun. 2010) 3 4 22 64
- E2 interaction and dimerization in the crystal structure of TRAF6. (PMID: 19465916) Yin Q. … Wu H. (Nat. Struct. Mol. Biol. 2009) 3 4 22 64
- Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PMID: 18093978) Pham L.V. … Ford R.J. (J. Biol. Chem. 2008) 3 4 22 64
- The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PMID: 18758450) Sorrentino A. … Landstrom M. (Nat. Cell Biol. 2008) 3 4 22 64
Products for TRAF6 Gene
- R&D Systems Antibodies for TRAF6 (TRAF-6)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for TRAF6 (TRAF-6)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TRAF6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRAF6
- Search Origene for MassSpec and Protein Over-expression Lysates for TRAF6
- Origene Custom Protein Services for TRAF6
- Origene shRNA products in human, mouse, rat for TRAF6
- Browse OriGene Inhibitory RNA Products For TRAF6
- OriGene qPCR primer pairs and template standards for TRAF6
- OriGene qPCR primer pairs for TRAF6
- OriGene CRISPR knockouts for TRAF6
- OriGene ORF clones in human for TRAF6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRAF6
- GenScript: Next-day shipping of latest version cDNA ORF clones for TRAF6 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TRAF6
- GenScript Custom Assay Services for TRAF6
- GenScript Custom overexpressing Cell Line Services for TRAF6
- GenScript: Design CRISPR guide RNA sequences for TRAF6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TRAF6
- Cell Signaling Technology (CST) Antibodies for TRAF6 (TRAF6)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for TRAF6
- Novus Biologicals proteins and lysates for TRAF6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for TRAF6
- Cloud-Clone Corp. Proteins for TRAF6
- Cloud-Clone Corp. Assay Kits for TRAF6
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TRAF6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TRAF6
- antibodies-online Antibodies for TRAF6: See all 140
- antibodies-online Kits for TRAF6: See all 10
- antibodies-online Proteins for TRAF6: See all 12
- Search antibodies-online for peptides
- GeneTex TRAF6 antibody for TRAF6
- Search GeneTex for Proteins for TRAF6
- ViGene Biosciences adenoviral particle packaged cDNA for TRAF6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRAF6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRAF6 gene
- Search ViGene Biosciences for TRAF6
- Santa Cruz Biotechnology (SCBT) Antibodies for TRAF6
- Search Santa Cruz Biotechnology (SCBT) for TRAF6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRAF6
- Custom Antibody ServicesProSci Antibodies for TRAF6
- Search for TRAF6 Proteins at ProSci
- Horizon Cell Lines for TRAF6
- Cyagen custom Knockout/knockin (KOKI) mouse models for TRAF6
- VectorBuilder custom plasmid, inducible vectors for TRAF6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TRAF6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TRAF6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio