TRAF6 Gene
protein-coding GIFtS: 67
GCID: GC11M036467
|
|
TNF receptor-associated factor 6, E3 ubiquitin protein ligase(Previous name: TNF receptor-associated factor 6 )
| |
Aliases
for TRAF6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNF Receptor-Associated Factor 6, E3 Ubiquitin Protein Ligase1 2 | | E3 Ubiquitin-Protein Ligase TRAF62 3 | | RNF851 2 3 | | RING Finger Protein 852 3 | | TNF Receptor-Associated Factor 61 2 | | MGC:33102 | | Interleukin-1 Signal Transducer2 3 | | EC 6.3.2.-3 |
Export aliases for TRAF6 gene to outside databasesPrevious GC identifers: GC11M038067 GC11M037188 GC11M036549 GC11M036475 GC11M036212 |
Summaries
for TRAF6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRAF6:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteinsare associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This proteinmediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals fromreceptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein alsointeracts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinctsignaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaBkinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, andUBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been foundto be required for IKK activation by this protein. This protein also interacts with the transforming growth factor(TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This proteinhas an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and ahighly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants,encoding an identical protein, have been reported. (provided by RefSeq, Feb 2012)
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediatesubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation ofNF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role indendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes.Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) andNF-kappa-B, in response to RANK-L stimulation
Gene Wiki entry for TRAF6
|
Genomic Views
for TRAF6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRAF6 gene promoter:
USF1 FOXJ2 (long isoform) USF-1 STAT3 FOXJ2 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRAF6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p12 Ensembl cytogenetic band: 11p12 HGNC cytogenetic band: 11p12TRAF6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M036467: view genomic region
(about GC identifiers)
Start:
|
36,508,577 bp from pter |
End:
|
36,531,822 bp from pter |
Size:
|
23,246 bases |
Orientation:
|
minus strand |
|
Proteins
for TRAF6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3 (See
protein sequence)Recommended Name: TNF receptor-associated factor 6 Size: 522 amino acids; 59573 Da
Subunit: Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing amode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complexrecruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents thecomplex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated geneexpression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1,MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts withIL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1.Interacts with TRAFD1. Interacts with ZNF675. Interacts with AJUBA. Interacts with TICAM1 and TICAM2. Interacts withZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interactswith UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains)with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1. Interactswith TRAF3IP2. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity).Interacts with IFIT3 (via N-terminus)
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet (By similarity). Note=Found in thenuclei of some agressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- andB-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm andsumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity)
6/8 PDB 3D structures from  and Proteopedia  for TRAF6 (see all 8):1LB4 (3D)
1LB5 (3D)
1LB6 (3D)
2ECI (3D)
2JMD (3D)
3HCS (3D)
Secondary accessions: A6NKI7 A8KAB3 D3DR16 Q8NEH5Explore the universe of human proteins at neXtProt for TRAF6: NX_Q9Y4K3
Post-translational modifications:
Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO11
Polyubiquitinated on Lys-124; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulationleads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N andUBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated withthe activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4K3
TRAF6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004611.1 NP_665802.1
ENSEMBL proteins: ENSP00000433623 ENSP00000337853 Reactome Protein details: Q9Y4K3
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
TRAF6 for ontologies About GeneDecksing
TRAF6 Antibody Products:
Assay Products for TRAF6: |
Protein
Domains /
Families
for TRAF6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRAF6 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9Y4K3ProtoNet protein and cluster: Q9Y4K3 3 Blocks protein families: IPB001293 Zn-finger IPB001841 Zn-finger IPB002083 Meprin/TRAF-like MATH
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3Domain: The coiled coil domain mediates homo- and hetero-oligomerizationDomain: The MATH/TRAF domain binds to receptor cytoplasmic domainsSimilarity: Belongs to the TNF receptor-associated factor family. A subfamilySimilarity: Contains 1 MATH domainSimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 2 TRAF-type zinc fingers |
Function
for TRAF6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediatesubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation ofNF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role indendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes.Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) andNF-kappa-B, in response to RANK-L stimulation Genatlas biochemistry entry for TRAF6:tumor necrosis factor (TNF)-receptor-associated factor 6,cytoplasmic,involved in the activation of NFKB byTNFRSFs,associating with IRAK1 after stimulation by IL1B,also associating with TNFRSF11 and SRC and,in turn activatingthe kinase activity of SRC
Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TRAF6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF6 |
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
TRAF6 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TRAF6:
Animal Models:
Mouse knock-outs for TRAF6: Traf6tm1Mak Traf6tm1Jino Traf6tm1Ywc
15/17 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Traf6) (see all 17):
TRAF6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRAF6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/66 super-pathways (see all 66) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | BAFF in B-Cell Signaling | | | 3 | Signal Transduction | | | 4 | p75NTR signals via NF-kB | | | 5 | Toll Comparative Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for TRAF6 (see all 10)
2  R&D Systems Pathways for TRAF6
5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF6 (see all 21)
2 
Cell Signaling Technology (CST) Pathways for TRAF6
5/17  GeneGo (Thomson Reuters) Pathways for TRAF6 (see all 17)
5/17  BioSystems Pathways for TRAF6 (see all 17)
5/59 
Reactome Pathways for TRAF6 (see all 59)
5/17 
Kegg Pathways (Kegg details for TRAF6) (see all 17):
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3Pathway: Protein modification; protein ubiquitination
TRAF6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF6
5/505 Interacting proteins for TRAF6 (Q9Y4K31, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 505)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TAX1BP1 | Q86VP11, 2, 3 | EBI-359276,EBI-529518 MINT-6505191 MINT-5226512 MINT-6505206 MINT-6505175 MINT-6505156 I2D:
score=8 | | IRAK2 | O431871, 2, 3 | EBI-359276,EBI-447733 MINT-50485 I2D:
score=6 | | IRAK1 | P516171, 2, 3 | EBI-359276,EBI-358664 MINT-50484 I2D:
score=10 | | UBC | P0CG482, 3 | MINT-5226492 MINT-5226478 MINT-7297740 MINT-49604 MINT-6505225 I2D:
score=6 | | MALT1 | Q9UDY82, 3 | MINT-6177590 MINT-6177582 MINT-6177625 I2D:
score=7 |
About this table
Gene Ontology (GO): 5/62 biological process terms (GO ID links to tree view) (see all 62): About this table
TRAF6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRAF6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRAF6 for compounds About GeneDecksing
 Browse Tocris compounds for TRAF6
10/15 Novoseek chemical compound relationships for TRAF6 gene (see all 15) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tab-2 |
93.3 |
38 |
16251197 (4), 10882101 (4), 20222921 (4), 11259596 (3) (see all 17) |
| tab-1 |
83.1 |
5 |
16382137 (1), 18353240 (1), 12242293 (1), 17633026 (1) (see all 5) |
| bcma |
46.1 |
1 |
10908663 (1) |
| poly(i-c) |
40.9 |
2 |
14982987 (2) |
| zinc |
31.9 |
13 |
19465916 (3), 11751921 (2), 11438463 (1), 9928991 (1) (see all 10) |
| peptidoglycan |
26.3 |
4 |
17182109 (1), 16230348 (1), 11254583 (1) |
| nadph |
26.2 |
2 |
16052631 (1), 16286467 (1) |
| phosphatidylinositol |
20.2 |
2 |
11406619 (1), 14996708 (1) |
| tyrosine |
10.7 |
3 |
18070880 (2), 10635328 (1) |
| threonine |
9.65 |
2 |
8837778 (1), 10635328 (1) |
Search CenterWatch for drugs/clinical trials and news about TRAF6
|
Transcripts
for TRAF6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRAF6 gene (2 alternative transcripts): NM_004620.3 NM_145803.2 Unigene Cluster for TRAF6: TNF receptor-associated factor 6, E3 ubiquitin protein ligase Hs.444172 [show with all ESTs]Unigene Representative Sequence: NM_1458033 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526995(uc001mwq.2 uc001mws.2) ENST00000348124 ENST00000529150
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TRAF6 (NM_004620) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAF6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF6 |
Additional cDNA sequence: AK128396.1 AK292978.1 BC031052.1 U78798.1 3 DOTS entries: DT.100676763 DT.95268361 DT.211093 24/124 AceView cDNA sequences (see all 124): BU743323 AW467912 BX107988 AA906241 AA361471 AA456692 BM986953 AW957648 AA757006 AI275424 AA716577 BM855452 AW339590 BU739857 BF765244 BE222017 BF055574 AA917774 AW235589 AA972639 NM_004620 BG024717 BX950992 CR590964
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF6 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRAF6
|
Expression
for TRAF6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRAF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGACTGAC
About this image
See TRAF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF6
SOURCE GeneReport for Unigene cluster: Hs.444172
UniProtKB/Swiss-Prot: TRAF6_HUMAN, Q9Y4K3Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF6 (see all 13):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF6 |
Orthologs
for TRAF6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRAF6 gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRAF61 |
TNF receptor-associated factor 6 |
72.77(n)
76.69(a) |
|
423163 XM_421089.2 XP_421089.2 |
lizard
(Anolis carolinensis) |
Reptilia |
B9TWH7_ANOCA6 |
TNF receptor-associated factor 6 Fragment |
72(a) |
1 ↔ 1 |
1(53578439-53579038) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.146822 |
Xenopus laevis transcribed sequence with moderate similarity more |
73.58(n) |
|
CF342115.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi15f022 |
wufi15f02 |
76.73(n) |
|
327524 BC055214.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Traf61 |
TNF-receptor-associated factor 6 |
43.8(n)
33.61(a) |
|
31746 NM_078525.3 NP_511080.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
trf-16Y110A7A.26 |
-- |
21(a)17(a) |
possible orthologpossible ortholog |
III(13430361-13433337) I(5154532-5158470) |
ENSEMBL Gene Tree for TRAF6 (if available)
TreeFam Gene Tree for TRAF6 (if available) |
Paralogs
for TRAF6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRAF6 gene
- TRAF12 TRAF42 TRAF52 TRAF22 TRAF32
1 SIMAP similar gene for TRAF6 using alignment to 1 protein entry: TRAF6_HUMAN:TRAF2
TRAF6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRAF6
PGOHUM00000238497
|
Genomic Variants
for TRAF6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRAF6 (36508577 - 36531822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRAF6
1 CNV: 5274
Human Gene Mutation Database (HGMD): TRAF6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF6 |
|
Disorders
/ Diseases
for TRAF6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRAF6 for disorders About GeneDecksing
OMIM gene information: 602355
OMIM disorders: --
20/46  diseases for TRAF6 (see all 46): About MalaCardshuman t-cell leukemia virus type 1 hypohidrotic ectodermal dysplasia ectodermal dysplasia dengue hemorrhagic fever
hemorrhagic fever haemophilus influenzae malt lymphoma cylindromatosis
inflammatory bowel disease papillary thyroid carcinoma acute lymphoblastic leukemia rheumatoid arthritis
chronic lymphocytic leukemia lymphoblastic leukemia lymphocytic leukemia kawasaki disease
chagas disease osteoporosis multiple myeloma thyroid carcinoma
1 disease from the University of Copenhagen DISEASES database for TRAF6:Hypohidrotic ectodermal dysplasia 10/13 Novoseek disease relationships for TRAF6 gene (see all 13) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
71.7 |
88 |
12566447 (2), 9625770 (2), 14550571 (2), 18759964 (2) (see all 63) |
| tumors |
56.5 |
86 |
12566447 (2), 9625770 (2), 14550571 (2), 18759964 (2) (see all 60) |
| inflammation |
38.9 |
10 |
16143987 (2), 17925880 (1), 18093978 (1), 18772140 (1) (see all 5) |
| ectodermal dysplasia |
25.6 |
1 |
16527194 (1) |
| bone diseases |
14.6 |
1 |
18778854 (1) |
| rheumatoid arthritis |
6.12 |
2 |
18759964 (1) |
| virus infection |
3.1 |
3 |
19479062 (1), 20097753 (1) |
| bone loss |
1.75 |
2 |
12716453 (1), 15320903 (1) |
| pathological processes |
0 |
1 |
16697380 (1) |
| osteoporosis |
0 |
1 |
14579250 (1) |
Human Genome Epidemiology (HuGE) Navigator: TRAF6 (28 documents)
Export disorders for TRAF6 gene to outside databases
|
Publications
for TRAF6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRAF6 gene, integrated from 9 sources (see all 538):
(articles sorted by number of sources associating them with TRAF6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TRAF6 is a signal transducer for interleukin-1. (PubMed id 8837778)1, 2, 3, 9 Cao Z.... Goeddel D.V. (1996)
- NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. (PubMed id 20079715)1, 2, 9 Zhou L.... Huo K. (2010)
- E2 interaction and dimerization in the crystal structure of TRAF6. (PubMed id 19465916)1, 2, 9 Yin Q.... Wu H. (2009)
- Distinct molecular mechanism for initiating TRAF6 signalling. (PubMed id 12140561)1, 2, 9 Ye H.... Wu H. (2002)
- Structure, interactions, and dynamics of the RING domain from human TRAF6. (PubMed id 17327397)1, 2, 9 Mercier P....Spyracopoulos L. (2007)
- Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. (PubMed id 9432981)1, 2, 9 Kashiwada M.... Takemori T. (1998)
- Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PubMed id 18093978)1, 2, 9 Pham L.V....Ford R.J. (2008)
- Association of the p75 neurotrophin receptor with TRAF6. (PubMed id 9915784)1, 2, 9 Khursigara G.... Chao M.V. (1999)
- The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PubMed id 18758450)1, 2, 9 Sorrentino A.... Landstrom M. (2008)
- Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN- beta. (PubMed id 14982987)1, 2, 9 Jiang Z.... Li X. (2004)
|
External Searches for TRAF6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRAF6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRAF6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRAF6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRAF6 gene:
Search GeneIP for patents involving TRAF6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRAF6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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 | |
 |
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