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Aliases for TRAF6 Gene

Aliases for TRAF6 Gene

  • TNF Receptor Associated Factor 6 2 3 5
  • TNF Receptor-Associated Factor 6, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase TRAF6 3 4
  • E3 Ubiquitin-Protein Ligase TRAF6 3 4
  • Interleukin-1 Signal Transducer 3 4
  • RING Finger Protein 85 3 4
  • RNF85 3 4
  • TNF Receptor-Associated Factor 6 3
  • EC 2.3.2.27 4
  • MGC:3310 3

External Ids for TRAF6 Gene

Previous GeneCards Identifiers for TRAF6 Gene

  • GC11M038067
  • GC11M037188
  • GC11M036549
  • GC11M036475
  • GC11M036212

Summaries for TRAF6 Gene

Entrez Gene Summary for TRAF6 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]

GeneCards Summary for TRAF6 Gene

TRAF6 (TNF Receptor Associated Factor 6) is a Protein Coding gene. Diseases associated with TRAF6 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Incontinentia Pigmenti. Among its related pathways are TRAF Pathway and Bacterial infections in CF airways. GO annotations related to this gene include identical protein binding and ligase activity. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF6 Gene

  • E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Gene Wiki entry for TRAF6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF6 Gene

Genomics for TRAF6 Gene

Regulatory Elements for TRAF6 Gene

Enhancers for TRAF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G036487 1.4 Ensembl ENCODE 17 +22.2 22240 1.8 HNRNPUL1 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PRR5L TRAF6 RAG1 COMMD9 ENSG00000255060 GC11M036483
GH11G036541 1 Ensembl ENCODE 12 -30.9 -30888 0.4 CTCF TFAP4 PKNOX1 ATF1 USF1 TBL1XR1 SAP130 RAD21 FOXK2 IKZF2 RAG1 TRAF6 C11orf74 RAG2 GC11M036546
GH11G036626 1 ENCODE dbSUPER 10.5 -117.4 -117386 2.4 PKNOX1 FEZF1 ZIC2 RAD21 CTBP1 SCRT2 ZBTB20 TCF7L2 SCRT1 GFI1B RAG2 C11orf74 TRAF6 RAG1 GC11M036597 GC11M036644
GH11G036469 0.8 ENCODE 10.9 +40.2 40246 2.0 CTCF ZBTB21 INSM2 FEZF1 ZNF101 HIC1 ZNF366 SCRT2 ZNF600 KLF8 PRR5L ENSG00000255060 RAG1 TRAF6 COMMD9 GC11M036483 GC11P036439
GH11G036292 0.8 Ensembl 10.6 +217.6 217613 0.2 CTCF ESRRA CBX3 PTBP1 CHD4 CEBPG RAD21 CHAMP1 ARID3A ADNP RAG1 TRAF6 ENSG00000255060 COMMD9 PRR5L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAF6 on UCSC Golden Path with GeneCards custom track

Promoters for TRAF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000039051 513 2401 HDGF CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF207

Genomic Location for TRAF6 Gene

Chromosome:
11
Start:
36,483,767 bp from pter
End:
36,510,313 bp from pter
Size:
26,547 bases
Orientation:
Minus strand

Genomic View for TRAF6 Gene

Genes around TRAF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF6 Gene

Proteins for TRAF6 Gene

  • Protein details for TRAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4K3-TRAF6_HUMAN
    Recommended name:
    TNF receptor-associated factor 6
    Protein Accession:
    Q9Y4K3
    Secondary Accessions:
    • A6NKI7
    • A8KAB3
    • D3DR16
    • Q8NEH5

    Protein attributes for TRAF6 Gene

    Size:
    522 amino acids
    Molecular mass:
    59573 Da
    Quaternary structure:
    • Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI2 and PELI3. Binds UBE2V1. Interacts with TAX1BP1. Interacts with ZNF675. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts with RBCK1. Interacts with TRAF3IP2. Interacts with LIMD1 (via LIM domains) (By similarity). Interacts with RSAD2/viperin (By similarity). Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity). Interacts with ZFAND5. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with AJUBA. Interacts with MAVS/IPS1. Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with IFIT3 (via N-terminus). Interacts with TICAM2. Interacts with CARD14. Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity). Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989).

    Three dimensional structures from OCA and Proteopedia for TRAF6 Gene

neXtProt entry for TRAF6 Gene

Post-translational modifications for TRAF6 Gene

  • Polyubiquitinated on Lys-124; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This Lys-63 site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form. Deubiquitinated by USP10 in a TANK-dependent manner, leading to the negative regulation of NF-kappaB signaling upon DNA damage (PubMed:25861989).
  • Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAF6 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF6 (TRAF6)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRAF6

Assay Products

  • Cloud-Clone Corp. Assay Kits for TRAF6

No data available for DME Specific Peptides for TRAF6 Gene

Domains & Families for TRAF6 Gene

Suggested Antigen Peptide Sequences for TRAF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4K3

UniProtKB/Swiss-Prot:

TRAF6_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
genes like me logo Genes that share domains with TRAF6: view

Function for TRAF6 Gene

Molecular function for TRAF6 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 6,cytoplasmic,involved in the activation of NFKB by TNFRSFs,associating with IRAK1 after stimulation by IL1B,also associating with TNFRSF11 and SRC and,in turn activating the kinase activity of SRC
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Enzyme Numbers (IUBMB) for TRAF6 Gene

Gene Ontology (GO) - Molecular Function for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005164 tumor necrosis factor receptor binding IPI 11728344
GO:0005515 protein binding IPI 10094049
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRAF6: view
genes like me logo Genes that share phenotypes with TRAF6: view

Animal Models for TRAF6 Gene

MGI Knock Outs for TRAF6:

Animal Model Products

CRISPR Products

miRNA for TRAF6 Gene

miRTarBase miRNAs that target TRAF6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF6 Gene

Localization for TRAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF6 Gene

Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF6 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
endosome 5
mitochondrion 3
extracellular 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18093978
GO:0005737 cytoplasm IDA,IEA 16378096
GO:0005811 lipid particle ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TRAF6: view

Pathways & Interactions for TRAF6 Gene

SuperPathways for TRAF6 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 p75 NTR receptor-mediated signalling
3 Toll-Like receptor Signaling Pathways
4 RANK Signaling in Osteoclasts
5 Diseases associated with the TLR signaling cascade
genes like me logo Genes that share pathways with TRAF6: view

UniProtKB/Swiss-Prot Q9Y4K3-TRAF6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRAF6 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TRAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 18093978
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination IDA 15125833
GO:0001503 ossification IEA --
GO:0001843 neural tube closure IEA --
genes like me logo Genes that share ontologies with TRAF6: view

Drugs & Compounds for TRAF6 Gene

(7) Drugs for TRAF6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(8) Additional Compounds for TRAF6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF6: view

Transcripts for TRAF6 Gene

Unigene Clusters for TRAF6 Gene

TNF receptor-associated factor 6, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF6

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for TRAF6 Gene

GeneLoc Exon Structure for
TRAF6
ECgene alternative splicing isoforms for
TRAF6

Expression for TRAF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), Heart (7.5), and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF6 Gene



Protein tissue co-expression partners for TRAF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAF6 Gene:

TRAF6

SOURCE GeneReport for Unigene cluster for TRAF6 Gene:

Hs.444172

mRNA Expression by UniProt/SwissProt for TRAF6 Gene:

Q9Y4K3-TRAF6_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for TRAF6 Gene

  • Blood(2.6)
  • Bone(2.3)
  • Spleen(2.3)
  • Bone marrow(2.1)
  • Lung(2)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • integumentary
  • nervous
  • skeleton
Organs:
Head and neck:
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • scalp
  • skull
  • tooth
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with TRAF6: view

Primer Products

No data available for mRNA differential expression in normal tissues for TRAF6 Gene

Orthologs for TRAF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF6 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia TRAF6 34 35
  • 90.29 (n)
cow
(Bos Taurus)
Mammalia TRAF6 34 35
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Traf6 34 16 35
  • 87.1 (n)
rat
(Rattus norvegicus)
Mammalia Traf6 34
  • 85.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF6 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAF6 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF6 34 35
  • 72.67 (n)
lizard
(Anolis carolinensis)
Reptilia TRAF6 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia traf6 34
  • 66.35 (n)
Str.8271 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14682 34
zebrafish
(Danio rerio)
Actinopterygii traf6 34 35
  • 60.14 (n)
wufi15f02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1398 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003004 34
  • 46.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta Traf6 34
  • 43.22 (n)
Traf-like 35
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
Species where no ortholog for TRAF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF6 Gene

ENSEMBL:
Gene Tree for TRAF6 (if available)
TreeFam:
Gene Tree for TRAF6 (if available)

Paralogs for TRAF6 Gene

Paralogs for TRAF6 Gene

(1) SIMAP similar genes for TRAF6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TRAF6 Gene

genes like me logo Genes that share paralogs with TRAF6: view

Variants for TRAF6 Gene

Sequence variations from dbSNP and Humsavar for TRAF6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000043685 -- 36,495,108(+) ACAAC(G/T)AATTT intron-variant, utr-variant-3-prime
rs1000170608 -- 36,508,679(+) TAGAA(A/G)CAGAA intron-variant, upstream-variant-2KB
rs1000187526 -- 36,508,872(+) AATCT(A/C)AGTGT intron-variant, upstream-variant-2KB
rs1000271506 -- 36,502,393(+) ACCAT(C/T)ATGGT intron-variant
rs1000473497 -- 36,495,766(+) GCATG(C/T)CTGTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAF6 Gene

Variant ID Type Subtype PubMed ID
esv1601897 CNV insertion 17803354
esv1648317 CNV insertion 17803354
esv2422305 CNV duplication 17116639
esv2678965 CNV deletion 23128226
esv3416520 CNV insertion 20981092
esv3625956 CNV loss 21293372
nsv1042014 CNV loss 25217958
nsv467791 CNV gain 19166990
nsv554003 CNV gain 21841781
nsv975903 CNV duplication 23825009

Variation tolerance for TRAF6 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF6 Gene

Human Gene Mutation Database (HGMD)
TRAF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF6 Gene

Disorders for TRAF6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TRAF6 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant
  • hypohidrotic ectodermal dysplasia autosomal dominant
incontinentia pigmenti
  • bloch-sulzberger syndrome
immunodeficiency with hyper-igm, type 3
  • cd40 deficiency
ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive
  • ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive
toxoplasmosis
  • disseminated toxoplasmosis
- elite association - COSMIC cancer census association via MalaCards
Search TRAF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAF6

Genetic Association Database (GAD)
TRAF6
Human Genome Epidemiology (HuGE) Navigator
TRAF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF6
genes like me logo Genes that share disorders with TRAF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF6 Gene

Publications for TRAF6 Gene

  1. TRAF6 is a signal transducer for interleukin-1. (PMID: 8837778) Cao Z. … Goeddel D.V. (Nature 1996) 2 3 4 22 64
  2. NUMBL interacts with TRAF6 and promotes the degradation of TRAF6. (PMID: 20079715) Zhou L. … Huo K. (Biochem. Biophys. Res. Commun. 2010) 3 4 22 64
  3. E2 interaction and dimerization in the crystal structure of TRAF6. (PMID: 19465916) Yin Q. … Wu H. (Nat. Struct. Mol. Biol. 2009) 3 4 22 64
  4. Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification. (PMID: 18093978) Pham L.V. … Ford R.J. (J. Biol. Chem. 2008) 3 4 22 64
  5. The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. (PMID: 18758450) Sorrentino A. … Landstrom M. (Nat. Cell Biol. 2008) 3 4 22 64

Products for TRAF6 Gene

  • Addgene plasmids for TRAF6

Sources for TRAF6 Gene

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