Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRAF5 Gene

protein-coding GIFtS: 65
GCID: GC01P211499

TNF receptor-associated factor 5

Explore 15 diseases affiliated with
TRAF5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 5¹ ²
RNF84¹ ² ³
RING Finger Protein 84² ³
MGC:39780²

External Ids:	HGNC: 12035¹	Entrez Gene: 7188²	Ensembl: ENSG00000082512⁷	OMIM: 602356⁵	UniProtKB: O00463³

Export aliases for TRAF5 gene to outside databases

Previous GC identifers: GC01P210231 GC01P207335 GC01P208139 GC01P208579 GC01P207888 GC01P209566 GC01P182176

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF5:

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF)

protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc

fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor

superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor

(TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have

been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463

Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to

different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of

NF-kappa-B and probably JNK. Seems to be involved in apoptosis

Gene Wiki entry for TRAF5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRAF5 gene promoter:
CHOP-10 NF-kappaB1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRAF5 promoter sequence

Search SABiosciences Chromatin IP Primers for TRAF5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32

TRAF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P211499: view genomic region (about GC identifiers)

Start:	211,499,957 bp from pter	End:	211,548,288 bp from pter
Size:	48,332 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463 (See protein sequence)

Recommended Name: TNF receptor-associated factor 5

Size: 557 amino acids; 64406 Da

Subunit: Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3.

Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17,

TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2

Subcellular location: Cytoplasm (Probable)

Secondary accessions: Q6FHY1

Explore the universe of human proteins at neXtProt for TRAF5: NX_O00463

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00463

TRAF5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001029082.1 NP_004610.1 NP_665702.1

ENSEMBL proteins:

ENSP00000261464 ENSP00000355971 ENSP00000336825 ENSP00000389891

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TRAF5 OriGene Protein Over-expression Lysate (see all 5): TRAF5 OriGene Custom Protein Services for TRAF5
	GenScript Custom Purified and Recombinant Proteins Services for TRAF5
	Novus Biologicals TRAF5 Protein Novus Biologicals TRAF5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRAF5

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	--
GO:0009898	internal side of plasma membrane	ISS	--
GO:0035631	CD40 receptor complex	ISS	--

TRAF5 for ontologies About GeneDecksing

TRAF5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TRAF5 (TRAF-5)
	Browse OriGene Antibodies OriGene Custom Antibody Services for TRAF5
	GenScript Custom Superior Antibodies Services for TRAF5
	Novus Biologicals TRAF5 Antibodies
	Abcam antibodies for TRAF5
	Uscn Antibodies for TRAF5
	ThermoFisher Antibodies for TRAF5

Assay Products for TRAF5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRAF5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRAF5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRAF5 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR008974 TRAF-like

IPR017907 Znf_RING_CS

IPR002083 MATH

IPR027130 TRAF5

IPR001841 Znf_RING

Graphical View of Domain Structure for InterPro Entry O00463

ProtoNet protein and cluster: O00463

3 Blocks protein families:

IPB001293 Zn-finger

IPB001841 Zn-finger

IPB002083 Meprin/TRAF-like MATH

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463

Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains

Similarity: Belongs to the TNF receptor-associated factor family. A subfamily

Similarity: Contains 1 MATH domain

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 2 TRAF-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463

Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to

different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of

NF-kappa-B and probably JNK. Seems to be involved in apoptosis

Genatlas biochemistry entry for TRAF5:

tumor necrosis factor (TNF)-receptor-associated factor 5,expressed in all visceral organs,interacting with the

lymphotoxin beta receptor,activating NFKB through the cytoplasmic domain of CD40 (TNFRSF5) and modulating of its

activity

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TRAF5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF5
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF5 (see all 13):
		hsa-miR-4307 hsa-miR-1226 hsa-miR-601 hsa-miR-634 hsa-miR-29a hsa-miR-29c hsa-miR-26b* hsa-miR-218

		SwitchGear 3'UTR luciferase reporter plasmid: TRAF5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF5 (see all 4) OriGene shRNA RFP: TRAF5 OriGene siRNA: TRAF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRAF5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TRAF5 (NM_145759)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRAF5
		Search LifeMap BioReagents cell lines for TRAF5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	9162022
GO:0008270	zinc ion binding	IEA	--
GO:0031625	ubiquitin protein ligase binding	IPI	11279055

TRAF5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TRAF5:

Decreased viability of wild-ty

Animal Models:
Mouse knock-out Traf5^tm1Hna for TRAF5
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Traf5):

cellular

hematopoietic system

immune system

TRAF5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

BAFF in B-Cell Signaling

BAFF in B-Cell Signaling	1.00	Apoptosis and survival APRIL and BAFF signaling	0.39
APRIL Pathway	0.92	RANK Pathway	0.29
RANK Signaling in Osteoclasts	0.45	RANKL/RANK Signaling Pathway	0.24
Apoptosis and survival_APRIL and BAFF signaling	0.39

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46
	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46

Apoptosis and survival_Lymphotoxin-beta receptor signaling

	Apoptosis and survival Lymphotoxin-beta receptor signaling	1.00			LT-BetaR Pathway	0.46
	Apoptosis and survival_Lymphotoxin-beta receptor signaling	1.00

TRAF Pathway

TRAF Pathway

1.00

TNF Superfamily Pathway

0.42

4-1BB Pathway

CD40 Signaling

0.54

CD27 Pathway

0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for TRAF5

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Apoptosis and survival Lymphotoxin-beta receptor signaling
	Apoptosis and survival APRIL and BAFF signaling
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF5 (see all 11)

	LT-BetaR Pathway
	TRAF Pathway
	NF-KappaB Family Pathway
	OX40 Pathway
	CD27 Pathway

4 GeneGo (Thomson Reuters) Pathways for TRAF5

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival APRIL and BAFF signaling
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Apoptosis and survival Lymphotoxin-beta receptor signaling

3 BioSystems Pathways for TRAF5

	TNF-alpha/NF-kB Signaling Pathway
	RANKL/RANK Signaling Pathway
	TWEAK Signaling Pathway

2 Kegg Pathways (Kegg details for TRAF5):

	Pathways in cancer
	Small cell lung cancer

TRAF5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRAF5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/58 Interacting proteins for TRAF5 (O00463^{1, 2, 3} ENSP00000261464⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFRSF14	Q92956¹^,³, ENSP00000347948⁴	EBI-523498,EBI-1056653 I2D: score=4 STRING: ENSP00000347948
ZMYND11	Q15326²^,³, ENSP00000309992⁴	MINT-7556634 I2D: score=1 STRING: ENSP00000309992
TNFRSF11A	Q9Y6Q6³, ENSP00000269485⁴	I2D: score=6 STRING: ENSP00000269485
TNFRSF13B	O14836³, ENSP00000261652⁴	I2D: score=4 STRING: ENSP00000261652
TNFRSF4	P43489³, ENSP00000368538⁴	I2D: score=4 STRING: ENSP00000368538

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007165	signal transduction	TAS	9511754
GO:0008284	positive regulation of cell proliferation	IEA	--
GO:0042981	regulation of apoptotic process	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP	12761501

TRAF5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRAF5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRAF5
1 Novoseek chemical compound relationship for TRAF5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	0	1	8663299 (1)

Search CenterWatch for drugs/clinical trials and news about TRAF5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRAF5 gene (3 alternative transcripts):

NM_001033910.2 NM_004619.3 NM_145759.2

Unigene Cluster for TRAF5:

TNF receptor-associated factor 5

Hs.523930 [show with all ESTs]

Unigene Representative Sequence: NM_001033910

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000462410 ENST00000488428 ENST00000494355 ENST00000261464(uc001hii.3 uc010psx.2 uc010psy.2 uc001hij.3)

ENST00000367004 ENST00000473385 ENST00000336184(uc001hih.3) ENST00000427925

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TRAF5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF5
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF5 (see all 13):
		hsa-miR-4307 hsa-miR-1226 hsa-miR-601 hsa-miR-634 hsa-miR-29a hsa-miR-29c hsa-miR-26b* hsa-miR-218

		SwitchGear 3'UTR luciferase reporter plasmid: TRAF5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF5 (see all 4) OriGene shRNA RFP: TRAF5 OriGene siRNA: TRAF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TRAF5 (NM_145759)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRAF5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF5

Additional cDNA sequence:

AB000509.1 AK130801.1 AK295766.1 AK303286.1 BC029600.1 CR536557.1 U69108.1

6 DOTS entries:

DT.215136 DT.100749929 DT.100737083 DT.121373953 DT.40202345 DT.40307155

24/99 AceView cDNA sequences (see all 99):

CB151573 AI432683 AA047258 AA688009 AI523215 BM677551 AA688228 CD637403

AA287167 NM_004619 AK126502 AW339080 AB000509 C01901 BQ961524 AA804956

N31570 BX106715 AI364686 AA740600 AW662482 AI453169 BM453281 CB147756

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF5 (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17a	·	17b	·	17c
SP1:																	-		-		-												-		-
SP2:									-								-		-		-												-		-
SP3:			-		-		-		-								-		-		-
SP4:									-								-		-
SP5:									-								-		-		-		-		-		-		-

ECgene alternative splicing isoforms for TRAF5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRAF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTTGCTTAG

About this image

TRAF5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRAF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF5

SOURCE GeneReport for Unigene cluster: Hs.523930

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463

Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood

SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF5:

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRAF5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRAF5 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRAF5¹	TNF receptor-associated factor 5	73.18(n) 71.61(a)		374055 NM_204219.2 NP_989550.1
lizard (Anolis carolinensis)	Reptilia	TRAF5⁶	--	67(a)	1 ↔ 1	1(237878030-237897346)
zebrafish (Danio rerio)	Actinopterygii	traf5⁶	Tnf receptor-associated factor 5	37(a)	1 ↔ 1	22(41260579-41281962)
worm (Caenorhabditis elegans)	Secernentea	trf-1¹	Protein TRF-1	43.48(n) 31.16(a)		176767 NM_067372.3 NP_499773.2

ENSEMBL Gene Tree for TRAF5 (if available)
TreeFam Gene Tree for TRAF5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRAF5 gene

TRAF1² TRAF4² TRAF3² TRAF2² TRAF6²

4 SIMAP similar genes for TRAF5 using alignment to 3 protein entries: TRAF5_HUMAN (see all proteins):

TRAF3 TRIM60 TRAF1 TRAF2

TRAF5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145236722^1,2		--	211497985(+)	`TTTACC/TCTTTC`	1	--	us2k¹		0	--	--	--	--
rs80221933^1,2	F,	--	211497987(+)	`TACCCT/CTTCCA`	1	--	us2k¹		1		WA	118
rs192091105^1,2		--	211497999(+)	`TTAGAC/TGCAGC`	1	--	us2k¹		0	--	--	--	--
rs185017903^1,2		--	211498090(+)	`GCTTGA/GATGTA`	1	--	us2k¹		0	--	--	--	--
rs148736871^1,2		--	211498162(+)	`AATTAC/TAGTCA`	2	--	us2k¹		0	--	--	--	--
rs187782811^1,2		--	211498260(+)	`AAAAAC/TAGTAT`	2	--	us2k¹		0	--	--	--	--
rs6703361^1,2	C,F,A,	--	211498535(+)	`GAAGCG/AGCAGA`	2	--	us2k¹		7		WA NA CSA EA	366
rs12073144^1,2	C,F,	--	211498598(+)	`cactcC/Tagcct`	2	--	us2k¹		2		WA CSA	4
rs114393789^1,2	C,F,	--	211498740(+)	`GCCATC/TTCATT`	2	--	us2k¹		1		NA	120
rs191487066^1,2		--	211498957(+)	`AGTGCA/GCCAGC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAF5 (211499957 - 211548288 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRAF5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF5

DNA2.0 Custom Variant and Variant Library Synthesis for TRAF5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRAF5 for disorders           About GeneDecksing

OMIM gene information: 602356    OMIM disorders: --

15 diseases for TRAF5:    About MalaCards

mulibrey nanism non-hodgkin lymphoma ectodermal dysplasia hodgkin's lymphoma

chronic lymphocytic leukemia lymphocytic leukemia multiple myeloma hepatitis c

hepatitis b myeloma hepatitis leukemia

lung cancer prostatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for TRAF5:

Mulibrey nanism

2 Novoseek disease relationships for TRAF5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	63.9	10	9511754 (2), 9990007 (1), 9582383 (1), 9488716 (1) (see all 9)
tumors	47	11	9511754 (2), 9990007 (1), 17633021 (1), 9990039 (1) (see all 10)

Human Genome Epidemiology (HuGE) Navigator: TRAF5 (12 documents)

Export disorders for TRAF5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRAF5 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with TRAF5)

Utopia: connect your pdf to the dynamic
world of online information

Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. (PubMed id 9177772)^{1, 2, 9} Nakano H.... Okumura K. (1997)
Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PubMed id 9488716)^{1, 2, 9} Kawamata S.... Uchiyama T. (1998)
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)^{1, 2, 9} Mizushima S.... Inoue J. (1998)
ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PubMed id 9153189)^{1, 2, 9} Hsu H.... Boyle W.J. (1997)
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. (PubMed id 9774460)^{1, 2, 9} Wong B.R....Choi Y. (1998)
CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PubMed id 9718306)^{1, 2, 9} Pullen S.S....Kehry M.R. (1998)
B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PubMed id 10908663)^{1, 2, 9} Shu H.-B. and Johnson H. (2000)
Tumor necrosis factor receptor-associated factors (TRAFs). (PubMed id 11607847)^{1, 2, 9} Bradley J.R. and Pober J.S. (2001)
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. (PubMed id 9642260)^{1, 2, 9} McCarthy J.V.... Dixit V.M. (1998)
ASK1 is essential for JNK/SAPK activation by TRAF2. (PubMed id 9774977)^{1, 2, 9} Nishitoh H.... Ichijo H. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7188	HGNC: 12035	AceView: TRAF5	Ensembl:ENSG00000082512	euGenes: HUgn7188
ECgene: TRAF5	Kegg: 7188	H-InvDB: TRAF5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRAF5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TRAF5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TRAF5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRAF5 gene:
Search GeneIP for patents involving TRAF5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TRAF5 (TRAF-5)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TRAF5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF5
	OriGene Protein Over-expression Lysate for TRAF5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TRAF5		OriGene 3'-UTR Clone for TRAF5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TRAF5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRAF5		OriGene Custom Protein Services for TRAF5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRAF5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF5

	GenScript Custom Purified and Recombinant Proteins Services for TRAF5		GenScript cDNA clones with any tag delivered in your preferred vector for TRAF5
	GenScript Custom Assay Services for TRAF5		GenScript Custom Superior Antibodies Services for TRAF5
	GenScript Custom overexpressing Cell Line Services for TRAF5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TRAF5 promoter
	Search Chromatin IP Primers for TRAF5
	RT² qPCR Primer Assay in human, mouse, rat TRAF5
	GNC Network for TRAF5
	SABiosciences PCR Arrays including human, mouse, rat TRAF5

Search Tocris compounds for TRAF5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRAF5 antibodies
	TRAF5 proteins
	TRAF5 lysates

	Antibodies for TRAF5
	See all of Abcam's Antibodies, Kits and Proteins for TRAF5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TRAF5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TRAF5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5

	SwitchGear 3'UTR luciferase reporter plasmids for TRAF5
	SwitchGear Promoter luciferase reporter plasmids for TRAF5

ThermoFisher Antibodies for TRAF5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRAF5 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TRAF5 Gene

TNF receptor-associated factor 5

Aliases
for TRAF5 gene

Summaries
for TRAF5 gene

Genomic Views
for TRAF5 gene

Proteins
for TRAF5 gene

Protein Domains /
Families
for TRAF5 gene

Function
for TRAF5 gene

Pathways & Interactions
for TRAF5 gene

Drugs & Compounds
for TRAF5 gene

Transcripts
for TRAF5 gene

Expression
for TRAF5 gene

Orthologs
for TRAF5 gene

Paralogs
for TRAF5 gene

Genomic Variants
for TRAF5 gene

Disorders / Diseases
for TRAF5 gene

Publications
for TRAF5 gene

External Searches for TRAF5 gene

Genome Databases showing TRAF5 gene

Other Databases showing TRAF5 gene

Specialized Databases showing TRAF5 gene

Intellectual Property
for TRAF5 gene

Products
for TRAF5 gene

View Random Gene

Advanced Search

Export list of displayed genes

TRAF5 Gene

TNF receptor-associated factor 5

Aliasesfor TRAF5 gene

Summariesfor TRAF5 gene

Genomic Viewsfor TRAF5 gene

Proteinsfor TRAF5 gene

Protein Domains /Familiesfor TRAF5 gene

Functionfor TRAF5 gene

Pathways & Interactionsfor TRAF5 gene

Drugs & Compoundsfor TRAF5 gene

Transcriptsfor TRAF5 gene

Expression for TRAF5 gene

Orthologsfor TRAF5 gene

Paralogsfor TRAF5 gene

Genomic Variantsfor TRAF5 gene

Disorders / Diseasesfor TRAF5 gene

Publicationsfor TRAF5 gene

External Searches for TRAF5 gene

Genome Databases showing TRAF5 gene

Other Databases showing TRAF5 gene

Specialized Databases showing TRAF5 gene

Intellectual Propertyfor TRAF5 gene

Productsfor TRAF5 gene

View Random Gene

Aliases
for TRAF5 gene

Summaries
for TRAF5 gene

Genomic Views
for TRAF5 gene

Proteins
for TRAF5 gene

Protein Domains /
Families
for TRAF5 gene

Function
for TRAF5 gene

Pathways & Interactions
for TRAF5 gene

Drugs & Compounds
for TRAF5 gene

Transcripts
for TRAF5 gene

Expression
for TRAF5 gene

Orthologs
for TRAF5 gene

Paralogs
for TRAF5 gene

Genomic Variants
for TRAF5 gene

Disorders / Diseases
for TRAF5 gene

Publications
for TRAF5 gene

Intellectual Property
for TRAF5 gene

Products
for TRAF5 gene