Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRAF5 Gene

protein-coding   GIFtS: 68
GCID: GC01P211499

TNF Receptor-Associated Factor 5

  See TRAF5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TNF Receptor-Associated Factor 51 2
RNF842 3
RING Finger Protein 842 3
MGC:397802

External Ids:    HGNC: 120351   Entrez Gene: 71882   Ensembl: ENSG000000825127   OMIM: 6023565   UniProtKB: O004633   
ORGUL members:         

Export aliases for TRAF5 gene to outside databases

Previous GC identifers: GC01P210231 GC01P207335 GC01P208139 GC01P208579 GC01P207888 GC01P209566 GC01P182176


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRAF5 Gene:
The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor
(TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two
TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the
TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to
tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate
transcriptional splice variants have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRAF5 Gene:
TRAF5 (TNF receptor-associated factor 5) is a protein-coding gene. Diseases associated with TRAF5 include mulibrey nanism. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463
Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to
different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation
of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of
NF-kappa-B by EIF2AK2/PKR

Gene Wiki entry for TRAF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAF5 gene promoter:
         CHOP-10   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRAF5 promoter sequence
   Search Chromatin IP Primers for TRAF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32

TRAF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P211499:  view genomic region     (about GC identifiers)

Start:
211,499,957 bp from pter      End:
211,548,288 bp from pter
Size:
48,332 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463 (See protein sequence)
Recommended Name: TNF receptor-associated factor 5  
Size: 557 amino acids; 64406 Da
Subunit: Homotrimer (Probable). Heteromer with TRAF3. Associates with TNFRSF5/CD40 through interaction with TRAF3.
Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17,
TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2. Interacts (via
C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain)
Secondary accessions: Q6FHY1

Explore the universe of human proteins at neXtProt for TRAF5: NX_O00463

Explore proteomics data for TRAF5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys534
  • Modification sites at PhosphoSitePlus

  • See TRAF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001029082.1  NP_004610.1  NP_665702.1  

    ENSEMBL proteins: 
     ENSP00000261464   ENSP00000355971   ENSP00000336825   ENSP00000389891  

    TRAF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRAF5
    OriGene Protein Over-expression Lysate for TRAF5
    OriGene MassSpec for TRAF5
    OriGene Custom Protein Services for TRAF5
    GenScript Custom Purified and Recombinant Proteins Services for TRAF5
    Novus Biologicals TRAF5 Protein
    Novus Biologicals TRAF5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAF5

     
    Search eBioscience for Proteins for TRAF5 

    TRAF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TRAF5 (TRAF-5)
    OriGene Antibodies for TRAF5
    OriGene Custom Antibody Services for TRAF5
    Novus Biologicals TRAF5 Antibodies
    Abcam antibodies for TRAF5
    Cloud-Clone Corp. Antibodies for TRAF5
    ThermoFisher Antibodies for TRAF5
    LSBio Antibodies in human, mouse, rat for TRAF5

    TRAF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRAF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF5
    Cloud-Clone Corp. CLIAs for TRAF5
    Search eBioscience for ELISAs for TRAF5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR027130 TRAF5
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry O00463

    ProtoNet protein and cluster: O00463

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Similarity: Belongs to the TNF receptor-associated factor family. A subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 TRAF-type zinc fingers


    Find genes that share domains with TRAF5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF5_HUMAN, O00463
    Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to
    different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation
    of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of
    NF-kappa-B by EIF2AK2/PKR

         Genatlas biochemistry entry for TRAF5:
    tumor necrosis factor (TNF)-receptor-associated factor 5,expressed in all visceral organs,interacting with the
    lymphotoxin beta receptor,activating NFKB through the cytoplasmic domain of CD40 (TNFRSF5) and modulating of its
    activity

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI15121867
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI11279055
         
    Find genes that share ontologies with TRAF5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRAF5:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Traf5):
     hematopoietic system  immune system 

    Find genes that share phenotypes with TRAF5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Traf5tm1Hna for TRAF5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TRAF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAF5 (see all 13):
    hsa-miR-4307 hsa-miR-1226 hsa-miR-601 hsa-miR-634 hsa-miR-29a hsa-miR-29c hsa-miR-26b* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRAF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAF5
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRAF5

    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF5 (see all 17)
    OriGene ORF clones in mouse, rat for TRAF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRAF5 (NM_145759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRAF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRAF5_HUMAN, O00463: Cytoplasm (Probable). Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol IDA15121867
    GO:0009898cytoplasmic side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    Find genes that share ontologies with TRAF5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRAF5 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    2LT-BetaR Pathway
    LT-BetaR Pathway0.46
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    34-1BB Pathway
    CD40 Signaling0.54
    CD27 Pathway0.48
    4Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway
    Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway0.46
    Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway0.46
    5TRAF Pathway
    TRAF Pathway0.42
    TNF Superfamily Pathway0.42


    Find genes that share SuperPaths with TRAF5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRAF5 (see all 11)
        LT-BetaR Pathway
    TRAF Pathway
    NF-KappaB Family Pathway
    OX40 Pathway
    CD27 Pathway

    4 GeneGo (Thomson Reuters) Pathways for TRAF5
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival APRIL and BAFF signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    3 BioSystems Pathways for TRAF5
        TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway
    RANKL/RANK Signaling Pathway


    Selected Kegg Pathways  (Kegg details for TRAF5) (see all 7):
        NF-kappa B signaling pathway
    TNF signaling pathway
    Herpes simplex infection
    Epstein-Barr virus infection
    Pathways in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF5: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRAF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAF5 (O004631, 2, 3 ENSP000002614644) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF14Q929561, 3, ENSP000003479484EBI-523498,EBI-1056653 I2D: score=4 STRING: ENSP00000347948
    TRAF6Q9Y4K31, 3EBI-523498,EBI-359276 I2D: score=2 
    ZMYND11Q153262, 3, ENSP000003099924MINT-7556634 I2D: score=1 STRING: ENSP00000309992
    TNFRSF11AQ9Y6Q63, ENSP000002694854I2D: score=6 STRING: ENSP00000269485
    TNFRSF13BO148363, ENSP000002616524I2D: score=4 STRING: ENSP00000261652
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS9511754
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0042981regulation of apoptotic process IEA--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IEP12761501

    Find genes that share ontologies with TRAF5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAF5

    1 Novoseek inferred chemical compound relationship for TRAF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 0 1 8663299 (1)



    Find genes that share compounds with TRAF5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRAF5 gene (3 alternative transcripts): 
    NM_001033910.2  NM_004619.3  NM_145759.2  

    Unigene Cluster for TRAF5:

    TNF receptor-associated factor 5
    Hs.523930  [show with all ESTs]
    Unigene Representative Sequence: NM_001033910
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462410 ENST00000488428 ENST00000494355 ENST00000261464(uc001hii.3 uc010psx.2 uc010psy.2 uc001hij.3)
    ENST00000367004 ENST00000473385 ENST00000336184(uc001hih.3) ENST00000427925

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRAF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAF5 (see all 13):
    hsa-miR-4307 hsa-miR-1226 hsa-miR-601 hsa-miR-634 hsa-miR-29a hsa-miR-29c hsa-miR-26b* hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidTRAF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRAF5
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF5
    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF5 (see all 17)
    OriGene ORF clones in mouse, rat for TRAF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRAF5 (NM_145759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF5
      QuantiTect SYBR Green Assays in human, mouse, rat TRAF5
      QuantiFast Probe-based Assays in human, mouse, rat TRAF5

    Additional mRNA sequence: 

    AB000509.1 AK130801.1 AK295766.1 AK303286.1 BC029600.1 CR536557.1 U69108.1 

    6 DOTS entries:

    DT.215136  DT.100749929  DT.100737083  DT.121373953  DT.40202345  DT.40307155 

    Selected AceView cDNA sequences (see all 99):

    AI432683 AA047258 C01901 CB151573 BM453281 BQ961524 AA688009 AK126502 
    AW662482 AW339080 AA287167 BM677551 AI523215 AA804956 AB000509 NM_004619 
    AA740600 AI453169 AA688228 AI364686 BX106715 CD637403 N31570 AI870206 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAF5 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
    SP1:                                                  -     -     -                                   -     -                                 
    SP2:                          -                       -     -     -                                   -     -                                 
    SP3:        -     -     -     -                       -     -     -                                                                           
    SP4:                          -                       -     -                                                                                 
    SP5:                          -                       -     -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for TRAF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRAF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGCTTAG
    TRAF5 Expression
    About this image


    TRAF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TRAF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523930

    UniProtKB/Swiss-Prot: TRAF5_HUMAN, O00463
    Tissue specificity: Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral
    blood

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF5: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF5
    QuantiTect SYBR Green Assays in human, mouse, rat TRAF5
    QuantiFast Probe-based Assays in human, mouse, rat TRAF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf51 , 5 TNF receptor-associated factor 51, 5 81.93(n)1
    79.89(a)1
      1 (97.11 cM)5
    220331  NM_011633.21  NP_035763.21 
     1919974305 
    chicken
    (Gallus gallus)
    Aves TRAF51 TNF receptor-associated factor 5 73.18(n)
    71.61(a)
      374055  NM_204219.3  NP_989550.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF56
    TNF receptor-associated factor 5
    68(a)
    1 ↔ 1
    1(237878020-237899978)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004916041 TNF receptor-associated factor 5-like 64.22(n)
    59.37(a)
      100491604  XM_002934682.2  XP_002934728.2 
    zebrafish
    (Danio rerio)
    Actinopterygii traf51 Tnf receptor-associated factor 5 51.07(n)
    42.57(a)
      563887  XM_687249.6  XP_692341.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta Traf-like6
    TNF-receptor-associated factor-like
    16(a)
    many ↔ many
    X(16309079-16311618)
    worm
    (Caenorhabditis elegans)
    Secernentea trf-11 trf-1 44.57(n)
    35.91(a)
      176767  NM_067372.4  NP_499773.2 


    ENSEMBL Gene Tree for TRAF5 (if available)
    TreeFam Gene Tree for TRAF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRAF5 gene
    TRAF12  TRAF42  TRAF22  TRAF32  TRAF62  
    4 SIMAP similar genes for TRAF5 using alignment to 3 protein entries:     TRAF5_HUMAN (see all proteins):
    TRAF3    TRIM60    TRAF1    TRAF2

    Find genes that share paralogs with TRAF5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRAF5 (see all 959)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711346781,2
    C--182220706(-) GAAGG-/GTGTGTG 3 -- int12Minor allele frequency- GT:0.25NA 4
    rs1452367221,2
    --211497985(+) TTTACC/TCTTTC 1 -- us2k10--------
    rs802219331,2
    F--211497987(+) TACCCT/CTTCCA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1920911051,2
    --211497999(+) TTAGAC/TGCAGC 1 -- us2k10--------
    rs1850179031,2
    --211498090(+) GCTTGA/GATGTA 1 -- us2k10--------
    rs1487368711,2
    C--211498162(+) AATTAC/TAGTCA 2 -- us2k10--------
    rs1877828111,2
    --211498260(+) AAAAAC/TAGTAT 2 -- us2k10--------
    rs67033611,2
    C,F,A--211498535(+) GAAGCG/AGCAGA 2 -- us2k17Minor allele frequency- A:0.44WA NA CSA EA 366
    rs120731441,2
    C,F--211498598(+) cactcC/Tagcct 2 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1143937891,2
    C,F--211498740(+) GCCATC/TTCATT 2 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for TRAF5 (211499957 - 211548288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRAF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508059CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF5
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602356    OMIM disorders: --

    1 disease for TRAF5:    
    About MalaCards
    mulibrey nanism

    1 disease from the University of Copenhagen DISEASES database for TRAF5:
    Mulibrey nanism

    Find genes that share disorders with TRAF5           About GenesLikeMe

    2 Novoseek inferred disease relationships for TRAF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 63.9 10 9511754 (2), 9990007 (1), 9582383 (1), 9488716 (1) (see all 9)
    tumors 47 11 9511754 (2), 9990007 (1), 17633021 (1), 9990039 (1) (see all 10)

    Genetic Association Database (GAD): TRAF5
    Human Genome Epidemiology (HuGE) Navigator: TRAF5 (12 documents)

    Export disorders for TRAF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRAF5 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with TRAF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. (PubMed id 9177772)1, 2, 9 Nakano H.... Okumura K. (Genomics 1997)
    2. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PubMed id 9488716)1, 2, 9 Kawamata S.... Uchiyama T. (J. Biol. Chem. 1998)
    3. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). (PubMed id 9511754)1, 2, 9 Mizushima S.... Inoue J. (Gene 1998)
    4. ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. (PubMed id 9153189)1, 2, 9 Hsu H.... Boyle W.J. (J. Biol. Chem. 1997)
    5. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. (PubMed id 9774460)1, 2, 9 Wong B.R....Choi Y. (J. Biol. Chem. 1998)
    6. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PubMed id 9718306)1, 2, 9 Pullen S.S....Kehry M.R. (Biochemistry 1998)
    7. Investigation of association between the TRAF family genes and RA susceptibility. (PubMed id 17277003)1, 4, 9 Potter C....Barton A. (Ann. Rheum. Dis. 2007)
    8. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. (PubMed id 10908663)1, 2, 9 Shu H.-B. and Johnson H. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    9. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PubMed id 18990758)1, 4, 9 Cerhan J.R....Slager S.L. (amp 2008)
    10. TRAF family proteins link PKR with NF-kappa B activation. (PubMed id 15121867)1, 2, 9 Gil J.... Esteban M. (Mol. Cell. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7188 HGNC: 12035 AceView: TRAF5 Ensembl:ENSG00000082512 euGenes: HUgn7188
    ECgene: TRAF5 Kegg: 7188 H-InvDB: TRAF5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRAF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRAF5 gene:
    Search GeneIP for patents involving TRAF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TRAF5 (TRAF-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRAF5   OriGene RNAi products in human, mouse, rat for TRAF5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TRAF5  
     OriGene MassSpec something-or-other for TRAF5   OriGene clones in human, mouse for TRAF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRAF5   OriGene Purified Protein for TRAF5  
     OriGene ORF clones in mouse, rat for TRAF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRAF5   OriGene Custom Protein Services for TRAF5  

     
     
     Block miRNA regulation of human, mouse, rat TRAF5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRAF5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF5 Predesigned siRNA for gene silencing in human, mouse, rat TRAF5
     QuantiFast Probe-based Assays in human, mouse, rat TRAF5 QuantiTect SYBR Green Assays in human, mouse, rat TRAF5
     PCR Arrays including human, mouse, rat TRAF5 Search Chromatin IP Primers for TRAF5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF5  GeneGlobe Interaction Network for TRAF5
     Regulatory tfbs in TRAF5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRAF5 GenScript cDNA clones with any tag delivered in your preferred vector for TRAF5
     GenScript Custom Assay Services for TRAF5 GenScript Custom overexpressing Cell Line Services for TRAF5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRAF5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRAF5 antibodies
     TRAF5 proteins
     TRAF5 lysates
     Antibodies for TRAF5
     See all of Abcam's Antibodies, Kits and Proteins for TRAF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRAF5
     Antibodies for TRAF5
     ELISAs for TRAF5
     CLIAs for TRAF5



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF5
     SwitchGear 3'UTR luciferase reporter plasmids for TRAF5
     SwitchGear Promoter luciferase reporter plasmids for TRAF5
     ThermoFisher Antibodies for TRAF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF5
     LSBio Antibodies in human, mouse, rat for TRAF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TRAF5
      Search eBioscience for proteins for TRAF5
      Search eBioscience for elisas for TRAF5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRAF5 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4