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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF4 Gene

protein-coding   GIFtS: 65
GCID: GC17P027071

TNF Receptor-Associated Factor 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 41 2     MLN 622 3
Cysteine-Rich Domain Associated With RING And Traf Domains Protein 12 3     RING Finger Protein 832 3
Metastatic Lymph Node Gene 62 Protein2 3     Cysteine-Rich Domain Associated With Ring And TRAF Domain2
CART12 3     Malignant 622
MLN622 3     Tumor Necrosis Receptor-Associated Factor 4A2
RNF832 3     

External Ids:    HGNC: 120341   Entrez Gene: 96182   Ensembl: ENSG000000766047   OMIM: 6024645   UniProtKB: Q9BUZ43   

Export aliases for TRAF4 gene to outside databases

Previous GC identifers: GC17P026916 GC17P028970 GC17P026922 GC17P027216 GC17P024095 GC17P023279


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF4 Gene:
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with,
and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown
to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and
NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in
a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative
activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature
of only one has been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRAF4 Gene: 
TRAF4 (TNF receptor-associated factor 4) is a protein-coding gene. Diseases associated with TRAF4 include mulibrey nanism, and parathyroid adenoma, and among its related super-pathways are TNF Superfamily Pathway and TRKA Signaling. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4
Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR)
family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the
regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through
Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory
tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions

Gene Wiki entry for TRAF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF4 gene promoter:
         Nkx3-1   HFH-3   AP-1   ATF-2   Tal-1beta   C/EBPalpha   E47   CHOP-10   FOXI1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11-q21.3

TRAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027071:  view genomic region     (about GC identifiers)

Start:
27,071,002 bp from pter      End:
27,077,976 bp from pter
Size:
6,975 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4 (See protein sequence)
Recommended Name: TNF receptor-associated factor 4  
Size: 470 amino acids; 53543 Da
Subunit: Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with
SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and
TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell
membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton (Probable)
2 PDB 3D structures from and Proteopedia for TRAF4:
2EOD (3D)        2YUC (3D)    
Secondary accessions: O75615 Q14848 Q2KJU4 Q2PJN8
Alternative splicing: 2 isoforms:  Q9BUZ4-1   Q9BUZ4-2   

Explore the universe of human proteins at neXtProt for TRAF4: NX_Q9BUZ4

Explore proteomics data for TRAF4 at MOPED 

Post-translational modifications:

  • UniProtKB: Polyubiquitinated, leading to its proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUZ4

  • TRAF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAF4 Protein Expression
    REFSEQ proteins: NP_004286.2  
    ENSEMBL proteins: 
     ENSP00000262395   ENSP00000464097   ENSP00000415789   ENSP00000466306   ENSP00000438154  
     ENSP00000262396   ENSP00000464583   ENSP00000465164   ENSP00000468107   ENSP00000396602  

    Human Recombinant Protein Products for TRAF4: 
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    Novus Biologicals TRAF4 Proteins
    Novus Biologicals TRAF4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAF4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18087216
    GO:0005737cytoplasm IDA16157600
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005923tight junction IEA--

    TRAF4 for ontologies           About GeneDecksing



    TRAF4 Antibody Products: 
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    Assay Products for TRAF4: 
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    Cloud-Clone Corp. ELISAs for TRAF4 
    Cloud-Clone Corp. CLIAs for TRAF4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/10 InterPro protein domains (see all 10):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR001841 Znf_RING
     IPR027138 TRAF4

    Graphical View of Domain Structure for InterPro Entry Q9BUZ4

    ProtoNet protein and cluster: Q9BUZ4

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4
    Domain: The coiled coil domain mediates homo- and hetero-oligomerization (By similarity)
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)
    Similarity: Belongs to the TNF receptor-associated factor family. B subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 3 TRAF-type zinc fingers


    TRAF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF4_HUMAN, Q9BUZ4
    Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR)
    family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the
    regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through
    Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory
    tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions
    Induction: Up-regulated by bacterial lipopolysaccharides (LPS) and by single-stranded CpG oligodeoxynucleotide

         Genatlas biochemistry entry for TRAF4:
    tumor necrosis factor (TNF)-receptor-associated factor 4,specifically expressed in epithelial cells ,?nuclear

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS7592751
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI10514511
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IEA--
         
    TRAF4 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Traf4):
     cellular  embryogenesis  growth/size  immune system  limbs/digits/tail 
     mortality/aging  nervous system  pigmentation  reproductive system  respiratory system 
     skeleton 

    TRAF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF4: Traf4tm1Mrio Traf4tm1Lind Traf4tm2Lind

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF4 

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF4 (see all 48):
    hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-650 hsa-miR-3122 hsa-miR-3622b-3p hsa-miR-3612 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidTRAF4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRAF4 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TRAF Pathway
    TRAF Pathway0.42
    TNF Superfamily Pathway0.42
    2TRKA Signaling
    NGF Pathway0.75
    3NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    4Apoptosis and survival Lymphotoxin-beta receptor signaling
    LT-BetaR Pathway0.46
    5TWEAK Pathway
    TRAIL Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF4 (see all 6)
        LT-BetaR Pathway
    TRAF Pathway
    NGF Pathway
    TRAIL Pathway
    TNF Superfamily Pathway

    1 BioSystems Pathway for TRAF4
        TNF-alpha/NF-kB Signaling Pathway


    2         Kegg Pathways  (Kegg details for TRAF4):
        Pathways in cancer
    Small cell lung cancer


    TRAF4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/60 Interacting proteins for TRAF4 (Q9BUZ41, 2, 3 ENSP000002623954) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3MINT-61780 I2D: score=4 
    ZNF512BQ96KM62, 3MINT-60819 I2D: score=2 
    CCHCR1Q8TD313, ENSP000003795664I2D: score=3 STRING: ENSP00000379566
    ENSG00000206355Q8TD313I2D: score=3 
    ENSG00000206457Q8TD313I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0007250activation of NF-kappaB-inducing kinase activity ----
    GO:0007585respiratory gaseous exchange IEA--
    GO:0030323respiratory tube development IEA--

    TRAF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF4

    1 Novoseek inferred chemical compound relationship for TRAF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadph 38.3 6 15743827 (3), 16330715 (2), 12023963 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAF4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF4 gene (2 alternative transcripts): 
    NM_004295.3  NM_145751.1  

    Unigene Cluster for TRAF4:

    TNF receptor-associated factor 4
    Hs.8375  [show with all ESTs]
    Unigene Representative Sequence: NM_004295
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262395(uc002hcq.1 uc002hcs.3) ENST00000478021 ENST00000461195
    ENST00000498540 ENST00000422344 ENST00000586813 ENST00000444415 ENST00000394925
    ENST00000262396 ENST00000475329 ENST00000584944 ENST00000473421 ENST00000454852
    ENST00000578917 ENST00000469529 ENST00000580073
    miRNA
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    Additional mRNA sequence: 

    AF082185.1 AK300804.1 AY937222.1 AY937223.1 AY937224.1 AY937225.1 BC001769.1 BC026726.1 
    BC047358.1 X80200.1 

    13 DOTS entries:

    DT.415497  DT.40286866  DT.92040566  DT.120902400  DT.100804535  DT.91971266  DT.95232269  DT.100820277 
    DT.100820278  DT.100840393  DT.86853502  DT.91959849  DT.95232272 

    24/291 AceView cDNA sequences (see all 291):

    AW630111 BC047358 CB306062 AI824757 BM547806 BM469104 CR590816 AW236110 
    CR616018 CR602462 BU957420 CD722229 BM756061 BU153733 BU538139 AU100211 
    BQ226766 CB159171 CN479542 BX489512 BM831509 AL532358 BM475677 BX282703 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF4 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b
    SP1:              -     -     -     -           -     -     -     -     -                                                                     
    SP2:              -     -     -     -           -     -     -     -     -                 -     -                                             
    SP3:              -     -     -     -           -     -     -     -     -                                                                     
    SP4:                                            -     -     -     -     -                 -     -                                             
    SP5:              -     -     -     -           -     -     -     -                                                                           


    ECgene alternative splicing isoforms for TRAF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF4 expression in normal human tissues (normalized intensities)      TRAF4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGTGCC
    TRAF4 Expression
    About this image


    TRAF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Thalamus
             Septum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             colon ; endothelial cells   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   

    See TRAF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF4

    SOURCE GeneReport for Unigene cluster: Hs.8375

    UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4
    Tissue specificity: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell
    layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF4 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf41 , 5 TNF receptor associated factor 41, 5 89.65(n)1
    96.81(a)1
      11 (46.74 cM)5
    220321  NM_009423.41  NP_033449.21 
     781584995 
    chicken
    (Gallus gallus)
    Aves TRAF41 TNF receptor-associated factor 4 78.57(n)
    80.14(a)
      417577  XM_003642429.1  XP_003642477.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24662 Xenopus laevis transcribed sequence with moderate similarity more 76.28(n)    48044231 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.158932 Danio rerio mRNA for TRAF4 protein, splice variant more 79.24(n)    AJ556549.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Traf13
    Traf41
    embryonic morphogenesis3
    TNF-receptor-associated factor 41
    44(a)3
    53.79(n)1
    45.71(a)1
      24E43
    336381  NM_058068.31  NP_477416.11 
    worm
    (Caenorhabditis elegans)
    Secernentea trf-13   -- 27(a)   III(13501650-13503172)   --


    ENSEMBL Gene Tree for TRAF4 (if available)
    TreeFam Gene Tree for TRAF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF4 gene
    TRAF12  TRAF52  TRAF22  TRAF32  TRAF62  
    3 SIMAP similar genes for TRAF4 using alignment to 9 protein entries:     TRAF4_HUMAN (see all proteins):
    TRIM5    TRIM60    LNX1

    TRAF4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TRAF4
    PGOHUM00000263145 PGOHUM00000235413


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 SNPs in TRAF4 are shown (see all 163)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1820772691,2
    --27070300(+) GGCTTG/TCCTCT 1 -- us2k10--------
    rs356315051,2
    C,F,H--27070751(+) CTCTGG/AAGAAG 1 -- us2k18Minor allele frequency- A:0.01NS NA 288
    rs353857741,2
    C,F,H--27070854(+) CCCCAG/AGGGAA 1 -- us2k113Minor allele frequency- A:0.03NS NA WA 1478
    rs3695810991,2
    C--27070973(+) CGCGG-/CTCCGC 1 -- us2k10--------
    rs355925731,2
    C--27071109(+) CTCGCC/TCGTGC 1 -- ut515Minor allele frequency- T:0.00NS 184
    rs1837536341,2
    C--27071181(+) CTGCTA/GTGCCC 2 L syn10--------
    rs1997968531,2
    --27071190(+) CCACTA/GTGCGG 2 L syn10--------
    rs38331621,2
    C--27071443(+) GGAGG-/CCCCCC 1 -- int10--------
    rs1488001241,2
    --27071581(+) AGCCTA/TGAACT 1 -- int10--------
    rs115747581,2
    C--27071743(+) AGAAAG/AGCTGC 1 -- int13Minor allele frequency- A:0.03NA 44

    HapMap Linkage Disequilibrium report for TRAF4 (27071002 - 27077976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRAF4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908028CNV Loss21882294
    esv24071CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602464    OMIM disorders: --

    11 diseases for TRAF4:    About MalaCards
    mulibrey nanism    parathyroid adenoma    cblc    encephalitis
    crohn's disease    adenoma    hepatitis b    lung cancer
    endotheliitis    hepatitis    arthritis

    1 disease from the University of Copenhagen DISEASES database for TRAF4:
    Mulibrey nanism

    TRAF4 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for TRAF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 53.3 18 12354113 (2), 18087216 (1), 17927880 (1), 9488716 (1) (see all 11)
    breast carcinoma 31 8 17927880 (4), 7592751 (3), 16799635 (1)
    tumors 28.1 18 12354113 (2), 16799635 (2), 18087216 (1), 17927880 (1) (see all 10)
    metastasis 0 2 7592751 (1), 16799635 (1)

    Genetic Association Database (GAD): TRAF4
    Human Genome Epidemiology (HuGE) Navigator: TRAF4 (6 documents)

    Export disorders for TRAF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF4 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with TRAF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. (PubMed id 7592751)1, 2, 3, 9 Regnier C.H.... Rio M.-C. (1995)
    2. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2, 3 Tomasetto C.L.... Rio M.-C. (1995)
    3. TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. (PubMed id 18087216)1, 2, 9 Gu X....Nylander K. (2007)
    4. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PubMed id 16157600)1, 2, 9 Abell A.N. and Johnson G.L. (2005)
    5. Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis. (PubMed id 18953416)1, 2, 9 Kedinger V....Rio M.C. (2008)
    6. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. (PubMed id 12023963)1, 2, 9 Xu Y.C....Terada L.S. (2002)
    7. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PubMed id 10514511)1, 2, 9 Ye X....Bredesen D.E. (1999)
    8. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. (PubMed id 16052631)1, 2, 9 Takeshita F....Suzuki K. (2005)
    9. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    10. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. (PubMed id 19937093)1, 2 Li S....Zhang L. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9618 HGNC: 12034 AceView: TRAF4 Ensembl:ENSG00000076604 euGenes: HUgn9618
    ECgene: TRAF4 Kegg: 9618 H-InvDB: TRAF4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF4 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/traf4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAF4 gene:
    Search GeneIP for patents involving TRAF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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