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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRAF4 Gene

protein-coding GIFtS: 63
GCID: GC17P027071

TNF receptor-associated factor 4

Explore 11 diseases affiliated with
TRAF4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 4¹ ²		MLN 62² ³
CART1¹ ² ³		RING Finger Protein 83² ³
MLN62¹ ² ³		Cysteine-Rich Domain Associated With Ring And TRAF Domain²
RNF83¹ ² ³		Malignant 62²
Cysteine-Rich Domain Associated With RING And Traf Domains Protein 1² ³		Tumor Necrosis Receptor-Associated Factor 4A²
Metastatic Lymph Node Gene 62 Protein² ³

External Ids:	HGNC: 12034¹	Entrez Gene: 9618²	Ensembl: ENSG00000076604⁷	OMIM: 602464⁵	UniProtKB: Q9BUZ4³

Export aliases for TRAF4 gene to outside databases

Previous GC identifers: GC17P026916 GC17P028970 GC17P026922 GC17P027216 GC17P024095 GC17P023279

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF4:

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and

mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to

interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B

activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein

complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of

MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has

been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4

Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family

to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell

survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors.

Required for normal skeleton development, and for normal development of the respiratory tract (By similarity).

Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions

Gene Wiki entry for TRAF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRAF4 gene promoter:
Nkx3-1 HFH-3 AP-1 ATF-2 Tal-1beta C/EBPalpha E47 CHOP-10 FOXI1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRAF4 promoter sequence

Search SABiosciences Chromatin IP Primers for TRAF4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q12 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11-q21.3

TRAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P027071: view genomic region (about GC identifiers)

Start:	27,071,002 bp from pter	End:	27,077,976 bp from pter
Size:	6,975 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4 (See protein sequence)

Recommended Name: TNF receptor-associated factor 4

Size: 470 amino acids; 53543 Da

Subunit: Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1.

Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is

probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6

Subcellular location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane;

Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton (Probable)

2 PDB 3D structures from and Proteopedia for TRAF4:

2EOD (3D)

2YUC (3D)

Secondary accessions: O75615 Q14848 Q2KJU4 Q2PJN8

Alternative splicing: 2 isoforms: Q9BUZ4-1 Q9BUZ4-2

Explore the universe of human proteins at neXtProt for TRAF4: NX_Q9BUZ4

Post-translational modifications:

Polyubiquitinated, leading to its proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BUZ4

TRAF4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004286.2

ENSEMBL proteins:

ENSP00000262395 ENSP00000464097 ENSP00000415789 ENSP00000466306 ENSP00000438154

ENSP00000262396 ENSP00000464583 ENSP00000465164 ENSP00000468107 ENSP00000396602

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	Uscn Proteins for TRAF4

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18087216
GO:0005737	cytoplasm	IDA	16157600
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005923	tight junction	IEA	--

TRAF4 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TRAF4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRAF4 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR008974 TRAF-like

IPR017907 Znf_RING_CS

IPR002083 MATH

IPR001841 Znf_RING

IPR027138 TRAF4

Graphical View of Domain Structure for InterPro Entry Q9BUZ4

ProtoNet protein and cluster: Q9BUZ4

3 Blocks protein families:

IPB001293 Zn-finger

IPB001841 Zn-finger

IPB002083 Meprin/TRAF-like MATH

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4

Domain: The coiled coil domain mediates homo- and hetero-oligomerization (By similarity)

Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains (By similarity)

Similarity: Belongs to the TNF receptor-associated factor family. B subfamily

Similarity: Contains 1 MATH domain

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 3 TRAF-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4

Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family

to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell

survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors.

Required for normal skeleton development, and for normal development of the respiratory tract (By similarity).

Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions

Induction: Up-regulated by bacterial lipopolysaccharides (LPS) and by single-stranded CpG oligodeoxynucleotide

Genatlas biochemistry entry for TRAF4:

tumor necrosis factor (TNF)-receptor-associated factor 4,specifically expressed in epithelial cells ,?nuclear

miRNA Products:		OriGene 3'-UTR Clone: TRAF4 Browse MicroRNA Expression Plasmids
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		hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-650 hsa-miR-3122 hsa-miR-3622b-3p hsa-miR-3612 hsa-miR-4264

		SwitchGear 3'UTR luciferase reporter plasmid: TRAF4 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF4

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	7592751
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	10514511
GO:0008270	zinc ion binding	IEA	--
GO:0019901	protein kinase binding	IEA	--

TRAF4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for TRAF4: Traf4^tm1Mrio Traf4^tm1Lind Traf4^tm2Lind
     11 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Traf4):

cellular	embryogenesis	growth/size	immune system	limbs/digits/tail
mortality/aging	nervous system	pigmentation	reproductive system	respiratory system
skeleton

TRAF4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF Pathway

TRAF Pathway

1.00

TNF Superfamily Pathway

0.42

NF-KappaB Family Pathway

NF-KappaB Family Pathway

1.00

TNF-alpha/NF-kB Signaling Pathway

TNF-alpha/NF-kB Signaling Pathway

1.00

Small cell lung cancer

Small cell lung cancer

1.00

Pathways in cancer

Pathways in cancer

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF4 (see all 6)

	LT-BetaR Pathway
	TRAF Pathway
	NGF Pathway
	TRAIL Pathway
	TNF Superfamily Pathway

1 BioSystems Pathway for TRAF4

TNF-alpha/NF-kB Signaling Pathway

2 Kegg Pathways (Kegg details for TRAF4):

	Pathways in cancer
	Small cell lung cancer

TRAF4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRAF4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for TRAF4 (Q9BUZ4^{1, 2, 3} ENSP00000262395⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMURF2	Q9HAU4²^,³	MINT-61780 I2D: score=4
ZNF512B	Q96KM6²^,³	MINT-60819 I2D: score=2
IRAK1	P51617³, ENSP00000358997⁴	I2D: score=4 STRING: ENSP00000358997
RPS6KB1	P23443³, ENSP00000225577⁴	I2D: score=4 STRING: ENSP00000225577
CCHCR1	Q8TD31³, ENSP00000379566⁴	I2D: score=3 STRING: ENSP00000379566

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007585	respiratory gaseous exchange	IEA	--
GO:0030323	respiratory tube development	IEA	--
GO:0042981	regulation of apoptotic process	IEA	--

TRAF4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRAF4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRAF4
1 Novoseek chemical compound relationship for TRAF4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nadph	38.3	6	15743827 (3), 16330715 (2), 12023963 (1)

Search CenterWatch for drugs/clinical trials and news about TRAF4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRAF4 gene (2 alternative transcripts):

NM_004295.3 NM_145751.1

Unigene Cluster for TRAF4:

TNF receptor-associated factor 4

Hs.8375 [show with all ESTs]

Unigene Representative Sequence: NM_004295

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262395(uc002hcq.1 uc002hcs.3) ENST00000478021 ENST00000461195

ENST00000498540 ENST00000422344 ENST00000586813 ENST00000444415 ENST00000394925

ENST00000262396 ENST00000475329 ENST00000584944 ENST00000473421 ENST00000454852

ENST00000578917 ENST00000469529 ENST00000580073

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		hsa-miR-29a hsa-miR-632 hsa-miR-346 hsa-miR-650 hsa-miR-3122 hsa-miR-3622b-3p hsa-miR-3612 hsa-miR-4264

		SwitchGear 3'UTR luciferase reporter plasmid: TRAF4 3' UTR sequence

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Additional cDNA sequence:

AF082185.1 AK300804.1 AY937222.1 AY937223.1 AY937224.1 AY937225.1 BC001769.1 BC026726.1

BC047358.1 X80200.1

13 DOTS entries:

DT.415497 DT.40286866 DT.92040566 DT.120902400 DT.100804535 DT.91971266 DT.95232269 DT.100820277

DT.100820278 DT.100840393 DT.86853502 DT.91959849 DT.95232272

24/291 AceView cDNA sequences (see all 291):

BM547811 AW630111 BC001769 CR616018 BU538139 CN482420 BX442370 AW410665

BM791217 CB124469 AU100211 BX362225 AA455501 BM839728 AW236110 BU625483

BM475677 AW302228 AL546722 CA432378 CR602462 X80200 BM831509 BG759077

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF4 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b
SP1:					-		-		-		-				-		-		-		-		-
SP2:					-		-		-		-				-		-		-		-		-						-		-
SP3:					-		-		-		-				-		-		-		-		-
SP4:															-		-		-		-		-						-		-
SP5:					-		-		-		-				-		-		-		-

ECgene alternative splicing isoforms for TRAF4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRAF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTGGTGCC

About this image

TRAF4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRAF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF4

SOURCE GeneReport for Unigene cluster: Hs.8375

UniProtKB/Swiss-Prot: TRAF4_HUMAN, Q9BUZ4

Tissue specificity: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer

of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus

SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF4:

TNF Ligands & Receptors in human mouse rat

Neurotoxicity in human mouse rat

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRAF4 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
chicken (Gallus gallus)	Aves	TRAF4¹	TNF receptor-associated factor 4	78.57(n) 80.14(a)	417577 XM_003642429.1 XP_003642477.1
African clawed frog (Xenopus laevis)	Amphibia	Xl.2466²	Xenopus laevis transcribed sequence with moderate similarity more	76.28(n)	48044231
zebrafish (Danio rerio)	Actinopterygii	Dr.15893²	Danio rerio mRNA for TRAF4 protein, splice variant more	79.24(n)	AJ556549.1
fruit fly (Drosophila melanogaster)	Insecta	Traf1³ Traf4¹	embryonic morphogenesis³ TNF-receptor-associated factor 4¹	44(a)³ 53.79(n)¹ 45.71(a)¹	24E4³ 33638¹ NM_058068.3¹ NP_477416.1¹
worm (Caenorhabditis elegans)	Secernentea	trf-1³	--	27(a)	III(13501650-13503172) --

ENSEMBL Gene Tree for TRAF4 (if available)
TreeFam Gene Tree for TRAF4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRAF4 gene

TRAF1² TRAF5² TRAF2² TRAF3² TRAF6²

3 SIMAP similar genes for TRAF4 using alignment to 9 protein entries: TRAF4_HUMAN (see all proteins):

TRIM5 TRIM60 LNX1

TRAF4 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TRAF4
PGOHUM00000263145 PGOHUM00000235413

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75850216^1,2	C,F,	--	27069024(+)	`ACCTCT/CGGACC`	2	--	us2k¹ ut3¹		1		WA	118
rs141685281^1,2		--	27069107(+)	`TGGATG/TGTGTC`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs186791558^1,2		--	27069161(+)	`GCCTTA/GGATAT`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs191309632^1,2		--	27069333(+)	`GCAGCC/TGGGCG`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs146209770^1,2		--	27069336(+)	`GCCGGA/GCGCAG`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs1142899^1,2	C,F,	--	27069393(+)	`GATCAC/TGAGGT`	2	--	us2k¹ ut3¹		5		NA	10
rs183805648^1,2		--	27069425(+)	`GCTAAC/TGTGGT`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs4795455^1,2	C,A,H,	--	27069435(+)	`tgaaaA/Ccccat`	2	--	us2k¹ ut3¹		1		NA	2
rs193042078^1,2		--	27069482(+)	`TGGCAC/TGCGCC`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs149884715^1,2		--	27069528(+)	`AATGGC/TGTAAA`	2	--	ut3¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAF4 (27071002 - 27077976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRAF4
1 CNV: 67168

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TRAF4 for disorders           About GeneDecksing

OMIM gene information: 602464    OMIM disorders: --

11 diseases for TRAF4:    About MalaCards

mulibrey nanism parathyroid adenoma breast carcinoma crohn's disease

hepatitis b encephalitis lung cancer adenoma

hepatitis carcinoma arthritis

1 disease from the University of Copenhagen DISEASES database for TRAF4:

Mulibrey nanism

4 Novoseek disease relationships for TRAF4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	53.3	18	12354113 (2), 18087216 (1), 17927880 (1), 9488716 (1) (see all 11)
breast carcinoma	31	8	17927880 (4), 7592751 (3), 16799635 (1)
tumors	28.1	18	12354113 (2), 16799635 (2), 18087216 (1), 17927880 (1) (see all 10)
metastasis	0	2	7592751 (1), 16799635 (1)

Human Genome Epidemiology (HuGE) Navigator: TRAF4 (6 documents)

Export disorders for TRAF4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRAF4 gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with TRAF4)

Utopia: connect your pdf to the dynamic
world of online information

Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. (PubMed id 7592751)^{1, 2, 3, 9} Regnier C.H.... Rio M.-C. (1995)
Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)^{1, 2, 3} Tomasetto C.L.... Rio M.-C. (1995)
TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN. (PubMed id 18087216)^{1, 2, 9} Gu X....Nylander K. (2007)
MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PubMed id 16157600)^{1, 2, 9} Abell A.N. and Johnson G.L. (2005)
Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis. (PubMed id 18953416)^{1, 2, 9} Kedinger V....Rio M.C. (2008)
Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. (PubMed id 12023963)^{1, 2, 9} Xu Y.C....Terada L.S. (2002)
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PubMed id 10514511)^{1, 2, 9} Ye X....Bredesen D.E. (1999)
TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. (PubMed id 16052631)^{1, 2, 9} Takeshita F....Suzuki K. (2005)
Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation. (PubMed id 19937093)^{1, 2} Li S....Zhang L. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9618	HGNC: 12034	AceView: TRAF4	Ensembl:ENSG00000076604	euGenes: HUgn9618
ECgene: TRAF4	Kegg: 9618	H-InvDB: TRAF4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRAF4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TRAF4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/traf4/

Intellectual Property for TRAF4 gene
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Patent Information for TRAF4 gene:
Search GeneIP for patents involving TRAF4

GeneCards and IP:
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