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Aliases for TRAF4 Gene

Aliases for TRAF4 Gene

  • TNF Receptor-Associated Factor 4 2 3
  • Cysteine-Rich Domain Associated With RING And Traf Domains Protein 1 3 4
  • Metastatic Lymph Node Gene 62 Protein 3 4
  • RING Finger Protein 83 3 4
  • MLN 62 3 4
  • CART1 3 4
  • MLN62 3 4
  • RNF83 3 4
  • Cysteine-Rich Domain Associated With Ring And TRAF Domain 3
  • Tumor Necrosis Receptor-Associated Factor 4A 3
  • Malignant 62 3

External Ids for TRAF4 Gene

Summaries for TRAF4 Gene

Entrez Gene Summary for TRAF4 Gene

  • This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAF4 Gene

TRAF4 (TNF Receptor-Associated Factor 4) is a Protein Coding gene. Diseases associated with TRAF4 include mulibrey nanism. Among its related pathways are Pathways in cancer and NF-KappaB Family Pathway. GO annotations related to this gene include protein kinase binding and ubiquitin protein ligase binding. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF4 Gene

  • Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

Gene Wiki entry for TRAF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF4 Gene

Genomics for TRAF4 Gene

Genomic Location for TRAF4 Gene

Start:
28,743,984 bp from pter
End:
28,750,958 bp from pter
Size:
6,975 bases
Orientation:
Plus strand

Genomic View for TRAF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF4 Gene

Regulatory Elements for TRAF4 Gene

Proteins for TRAF4 Gene

  • Protein details for TRAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUZ4-TRAF4_HUMAN
    Recommended name:
    TNF receptor-associated factor 4
    Protein Accession:
    Q9BUZ4
    Secondary Accessions:
    • O75615
    • Q14848
    • Q2KJU4
    • Q2PJN8

    Protein attributes for TRAF4 Gene

    Size:
    470 amino acids
    Molecular mass:
    53543 Da
    Quaternary structure:
    • Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6.

    Three dimensional structures from OCA and Proteopedia for TRAF4 Gene

    Alternative splice isoforms for TRAF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF4 Gene

Proteomics data for TRAF4 Gene at MOPED

Post-translational modifications for TRAF4 Gene

  • Polyubiquitinated, leading to its proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys170 and Lys415

No data available for DME Specific Peptides for TRAF4 Gene

Domains for TRAF4 Gene

Gene Families for TRAF4 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

TRAF4_HUMAN
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.:
    • Q9BUZ4
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.:
    • Q9BUZ4
  • Contains 1 MATH domain.:
    • Q9BUZ4
Family:
  • Belongs to the TNF receptor-associated factor family. B subfamily.:
    • Q9BUZ4
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9BUZ4
  • Contains 3 TRAF-type zinc fingers.:
    • Q9BUZ4
genes like me logo Genes that share domains with TRAF4: view

Function for TRAF4 Gene

Molecular function for TRAF4 Gene

GENATLAS Biochemistry: tumor necrosis factor (TNF)-receptor-associated factor 4,specifically expressed in epithelial cells ,?nuclear
UniProtKB/Swiss-Prot Function: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
UniProtKB/Swiss-Prot Induction: Up-regulated by bacterial lipopolysaccharides (LPS) and by single-stranded CpG oligodeoxynucleotide.

Gene Ontology (GO) - Molecular Function for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7592751
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005164 tumor necrosis factor receptor binding IPI 11728344
GO:0005515 protein binding IPI 10514511
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRAF4: view
genes like me logo Genes that share phenotypes with TRAF4: view

Animal Models for TRAF4 Gene

MGI Knock Outs for TRAF4:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRAF4 Gene

Localization for TRAF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF4 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF4 Gene COMPARTMENTS Subcellular localization image for TRAF4 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18087216
GO:0005737 cytoplasm IDA 16157600
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with TRAF4: view

Pathways for TRAF4 Gene

genes like me logo Genes that share pathways with TRAF4: view

Pathways by source for TRAF4 Gene

2 KEGG pathways for TRAF4 Gene

Gene Ontology (GO) - Biological Process for TRAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 7592751
GO:0007250 activation of NF-kappaB-inducing kinase activity IEA --
GO:0007585 respiratory gaseous exchange IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRAF4: view

Compounds for TRAF4 Gene

(1) Novoseek inferred chemical compound relationships for TRAF4 Gene

Compound -log(P) Hits PubMed IDs
nadph 38.3 6
genes like me logo Genes that share compounds with TRAF4: view

Transcripts for TRAF4 Gene

Unigene Clusters for TRAF4 Gene

TNF receptor-associated factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: - - - - -
SP11:
SP12: - - - -
SP13: - - - -
SP14: -

Relevant External Links for TRAF4 Gene

GeneLoc Exon Structure for
TRAF4
ECgene alternative splicing isoforms for
TRAF4

Expression for TRAF4 Gene

mRNA expression in normal human tissues for TRAF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF4 Gene

SOURCE GeneReport for Unigene cluster for TRAF4 Gene Hs.8375

mRNA Expression by UniProt/SwissProt for TRAF4 Gene

Q9BUZ4-TRAF4_HUMAN
Tissue specificity: Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
genes like me logo Genes that share expressions with TRAF4: view

Orthologs for TRAF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF4 36
  • 99.81 (n)
  • 100 (a)
TRAF4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAF4 36
  • 91.28 (n)
  • 98.09 (a)
TRAF4 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF4 36
  • 89.35 (n)
  • 94.55 (a)
TRAF4 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf4 36
  • 89.65 (n)
  • 96.81 (a)
Traf4 16
Traf4 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAF4 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 77 (a)
OneToMany
-- 37
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Traf4 36
  • 89.29 (n)
  • 97.02 (a)
chicken
(Gallus gallus)
Aves TRAF4 36
  • 78.59 (n)
  • 80.09 (a)
TRAF4 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 22 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.2466 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.392 36
traf4 36
  • 71.56 (n)
  • 77.87 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15893 36
traf4a 36
  • 72.77 (n)
  • 76.81 (a)
traf4a 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010017 36
  • 52.97 (n)
  • 46.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Traf4 36
  • 53.79 (n)
  • 45.71 (a)
Traf4 37
  • 34 (a)
OneToOne
Traf1 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea trf-1 37
  • 26 (a)
ManyToMany
trf-1 38
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2595 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for TRAF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF4 Gene

ENSEMBL:
Gene Tree for TRAF4 (if available)
TreeFam:
Gene Tree for TRAF4 (if available)

Paralogs for TRAF4 Gene

Paralogs for TRAF4 Gene

Selected SIMAP similar genes for TRAF4 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for TRAF4 Gene

genes like me logo Genes that share paralogs with TRAF4: view

Variants for TRAF4 Gene

Sequence variations from dbSNP and Humsavar for TRAF4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8198 -- 28,749,763(+) CTGTG(A/G)GGAAC utr-variant-3-prime
rs1044066 - 28,748,331(+) TGCGG(C/G/T)GGCTG reference, missense
rs1047167 -- 28,750,868(+) AGTTT(C/T)TGAGC utr-variant-3-prime
rs2070265 -- 28,748,405(+) GAGTT(C/T)GTCTT reference, synonymous-codon
rs3181215 -- 28,750,313(+) GGCCT(A/G)GATGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRAF4 Gene

Variant ID Type Subtype PubMed ID
nsv908028 CNV Loss 21882294
esv24071 CNV Loss 19812545

Relevant External Links for TRAF4 Gene

HapMap Linkage Disequilibrium report
TRAF4

Disorders for TRAF4 Gene

(1) MalaCards Diseases for TRAF4 Gene

Search for TRAF4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TRAF4 Gene

(4) Novoseek inferred disease relationships for TRAF4 Gene

Disease -log(P) Hits PubMed IDs
necrosis 53.3 12
breast carcinoma 31 8
tumors 28.1 12
metastasis 0 2

Relevant External Links for TRAF4

Genetic Association Database (GAD)
TRAF4
Human Genome Epidemiology (HuGE) Navigator
TRAF4
genes like me logo Genes that share disorders with TRAF4: view

No data available for UniProtKB/Swiss-Prot for TRAF4 Gene

Publications for TRAF4 Gene

  1. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. (PMID: 7592751) Regnier C.H. … Rio M.-C. (J. Biol. Chem. 1995) 2 3 4 23
  2. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (PMID: 10514511) Ye X. … Bredesen D.E. (J. Biol. Chem. 1999) 3 4 23
  3. Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. (PMID: 12023963) Xu Y.C. … Terada L.S. (J. Biol. Chem. 2002) 3 4 23
  4. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. (PMID: 16052631) Takeshita F. … Suzuki K. (Eur. J. Immunol. 2005) 3 4 23
  5. MEKK4 is an effector of the embryonic TRAF4 for JNK activation. (PMID: 16157600) Abell A.N. … Johnson G.L. (J. Biol. Chem. 2005) 3 4 23

Products for TRAF4 Gene

  • Addgene plasmids for TRAF4

Sources for TRAF4 Gene

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