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Aliases for TRAF3IP3 Gene

Aliases for TRAF3IP3 Gene

  • TRAF3 Interacting Protein 3 2 3 5
  • TRAF3 Interacting Jun N Terminal Kinase (JNK) Activating Modulator 2 3
  • T3JAM 3 4
  • TRAF3-Interacting JNK-Activating Modulator 3
  • TRAF3-Interacting Protein 3 4

External Ids for TRAF3IP3 Gene

Previous GeneCards Identifiers for TRAF3IP3 Gene

  • GC01P206318
  • GC01P207996
  • GC01P209929
  • GC01P180604

Summaries for TRAF3IP3 Gene

Entrez Gene Summary for TRAF3IP3 Gene

  • The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for TRAF3IP3 Gene

TRAF3IP3 (TRAF3 Interacting Protein 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SLMAP.

UniProtKB/Swiss-Prot for TRAF3IP3 Gene

  • May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Gene Wiki entry for TRAF3IP3 Gene

Additional gene information for TRAF3IP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3IP3 Gene

Genomics for TRAF3IP3 Gene

Regulatory Elements for TRAF3IP3 Gene

Enhancers for TRAF3IP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H209782 1.4 ENCODE dbSUPER 24.9 +29.6 29616 6 HDGF FOXA2 PKNOX1 ARNT SIN3A ARID4B ZNF2 YY1 ZNF766 CBX5 TRAF3IP3 IRF6 SYT14 C1orf74
GH01H209765 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.6 +12.5 12540 6.9 HDGF PKNOX1 TBL1XR1 YBX1 BATF ZEB1 ZNF766 ELK1 ATF7 ETV6 G0S2 TRAF3IP3 DIEXF ENSG00000224260 LAMB3 IRF6 C1orf74 LOC101930114
GH01H209754 1.5 FANTOM5 ENCODE dbSUPER 17.4 +1.0 1045 5.1 PKNOX1 YBX1 SCRT2 ATF7 ETV6 RUNX3 CREM IKZF2 CBFB ELF1 TRAF3IP3 G0S2 IRF6 C1orf74 LOC101930114
GH01H209800 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.5 +49.9 49889 10.2 HDGF PKNOX1 ARNT FEZF1 ZNF2 YY1 FOS SP3 REST MEF2D IRF6 TRAF3IP3 DIEXF SYT14 LAMB3 C1orf74
GH01H209746 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -8.6 -8581 2.3 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 G0S2 TRAF3IP3 LAMB3 GC01P209745
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Promoters for TRAF3IP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019416 1168 401 ZNF687 NR2F1 ELF1 EBF1 DPF2 REST POLR2A ETV6 RUNX3 IKZF2

Genomic Locations for TRAF3IP3 Gene

Genomic Locations for TRAF3IP3 Gene
26,292 bases
Plus strand

Genomic View for TRAF3IP3 Gene

Genes around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF3IP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF3IP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP3 Gene

Proteins for TRAF3IP3 Gene

  • Protein details for TRAF3IP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRAF3-interacting JNK-activating modulator
    Protein Accession:
    Secondary Accessions:
    • A1L464
    • A6NIU9
    • Q2YDB5
    • Q4VY06
    • Q7Z706

    Protein attributes for TRAF3IP3 Gene

    551 amino acids
    Molecular mass:
    63626 Da
    Quaternary structure:
    • Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.

    Alternative splice isoforms for TRAF3IP3 Gene


neXtProt entry for TRAF3IP3 Gene

Post-translational modifications for TRAF3IP3 Gene

  • Ubiquitination at posLast=267267
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRAF3IP3 Gene

Domains & Families for TRAF3IP3 Gene

Gene Families for TRAF3IP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TRAF3IP3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAF3IP3: view

No data available for UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Function for TRAF3IP3 Gene

Molecular function for TRAF3IP3 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Phenotypes From GWAS Catalog for TRAF3IP3 Gene

Gene Ontology (GO) - Molecular Function for TRAF3IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
genes like me logo Genes that share ontologies with TRAF3IP3: view
genes like me logo Genes that share phenotypes with TRAF3IP3: view

Animal Models for TRAF3IP3 Gene

MGI Knock Outs for TRAF3IP3:

miRNA for TRAF3IP3 Gene

miRTarBase miRNAs that target TRAF3IP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF3IP3 Gene

Localization for TRAF3IP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF3IP3 gene
Compartment Confidence
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAF3IP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAF3IP3: view

Pathways & Interactions for TRAF3IP3 Gene

SuperPathways for TRAF3IP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAF3IP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRAF3IP3 Gene

Drugs & Compounds for TRAF3IP3 Gene

No Compound Related Data Available

Transcripts for TRAF3IP3 Gene

mRNA/cDNA for TRAF3IP3 Gene

Unigene Clusters for TRAF3IP3 Gene

TRAF3 interacting protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: -
SP10: -

ExUns: 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - -
SP11: -

Relevant External Links for TRAF3IP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAF3IP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF3IP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAF3IP3 Gene

This gene is overexpressed in Whole Blood (x20.7), Spleen (x6.5), and Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for TRAF3IP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.6), Lymph node (9.2), and Pancreas (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF3IP3 Gene

Protein tissue co-expression partners for TRAF3IP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAF3IP3 Gene:


SOURCE GeneReport for Unigene cluster for TRAF3IP3 Gene:


Evidence on tissue expression from TISSUES for TRAF3IP3 Gene

  • Blood(4.6)
  • Nervous system(4.1)
  • Spleen(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TRAF3IP3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF3IP3 Gene

Orthologs for TRAF3IP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3IP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAF3IP3 33 34
  • 99.09 (n)
(Canis familiaris)
Mammalia TRAF3IP3 33 34
  • 88.5 (n)
(Bos Taurus)
Mammalia TRAF3IP3 33 34
  • 87.17 (n)
(Mus musculus)
Mammalia Traf3ip3 33 16 34
  • 82.91 (n)
(Rattus norvegicus)
Mammalia Traf3ip3 33
  • 81.33 (n)
(Monodelphis domestica)
Mammalia TRAF3IP3 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia TRAF3IP3 34
  • 60 (a)
(Gallus gallus)
Aves TRAF3IP3 33 34
  • 57.94 (n)
(Anolis carolinensis)
Reptilia TRAF3IP3 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145338 33
  • 51.52 (n)
(Danio rerio)
Actinopterygii LOC100534789 33
  • 43.78 (n)
CR847543.1 34
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17494 34
  • 9 (a)
(Caenorhabditis elegans)
Secernentea M4.1 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 34
  • 20 (a)
Species where no ortholog for TRAF3IP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3IP3 Gene

Gene Tree for TRAF3IP3 (if available)
Gene Tree for TRAF3IP3 (if available)

Paralogs for TRAF3IP3 Gene

Paralogs for TRAF3IP3 Gene

(2) SIMAP similar genes for TRAF3IP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAF3IP3: view

Variants for TRAF3IP3 Gene

Sequence variations from dbSNP and Humsavar for TRAF3IP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035664 A colorectal cancer sample
rs1000231099 -- 209,758,833(+) GGGTT(C/T)TAGGA intron-variant, utr-variant-5-prime
rs1000330841 -- 209,755,875(+) CCACA(A/G)AGGTC upstream-variant-2KB
rs1000846417 -- 209,772,021(+) GAAGT(C/G)TACGT intron-variant
rs1000940950 -- 209,770,491(+) GAAGT(A/G)TGCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP3 Gene

Variant ID Type Subtype PubMed ID
nsv952685 CNV deletion 24416366
nsv4343 CNV deletion 18451855
nsv159698 CNV deletion 16902084
nsv1150782 CNV deletion 26484159
nsv1006632 CNV gain 25217958
nsv1001588 CNV gain 25217958
esv3545800 CNV deletion 23714750
esv3449118 CNV duplication 20981092
esv3393757 CNV duplication 20981092
esv2722195 CNV deletion 23290073
esv2722184 CNV deletion 23290073
esv2722173 CNV deletion 23290073
esv2722162 CNV deletion 23290073
esv2491231 CNV deletion 19546169

Variation tolerance for TRAF3IP3 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF3IP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Disorders for TRAF3IP3 Gene

Relevant External Links for TRAF3IP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRAF3IP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAF3IP3 Gene

Publications for TRAF3IP3 Gene

  1. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). (PMID: 14572659) Dadgostar H … Cheng G (FEBS letters 2003) 2 3 22 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TRAF3IP3 Gene

Sources for TRAF3IP3 Gene

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