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Aliases for TRAF3IP3 Gene

Aliases for TRAF3IP3 Gene

  • TRAF3 Interacting Protein 3 2 3 5
  • TRAF3 Interacting Jun N Terminal Kinase (JNK) Activating Modulator 2 3
  • T3JAM 3 4
  • TRAF3-Interacting Protein 3 4

External Ids for TRAF3IP3 Gene

Previous GeneCards Identifiers for TRAF3IP3 Gene

  • GC01P206318
  • GC01P207996
  • GC01P209929
  • GC01P180604

Summaries for TRAF3IP3 Gene

Entrez Gene Summary for TRAF3IP3 Gene

  • The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for TRAF3IP3 Gene

TRAF3IP3 (TRAF3 Interacting Protein 3) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SLMAP.

UniProtKB/Swiss-Prot for TRAF3IP3 Gene

  • May function as an adapter molecule that regulates TRAF3-mediated JNK activation.

Gene Wiki entry for TRAF3IP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3IP3 Gene

Genomics for TRAF3IP3 Gene

Regulatory Elements for TRAF3IP3 Gene

Promoters for TRAF3IP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAF3IP3 Gene

Chromosome:
1
Start:
209,756,032 bp from pter
End:
209,782,323 bp from pter
Size:
26,292 bases
Orientation:
Plus strand

Genomic View for TRAF3IP3 Gene

Genes around TRAF3IP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF3IP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF3IP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP3 Gene

Proteins for TRAF3IP3 Gene

  • Protein details for TRAF3IP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y228-T3JAM_HUMAN
    Recommended name:
    TRAF3-interacting JNK-activating modulator
    Protein Accession:
    Q9Y228
    Secondary Accessions:
    • A1L464
    • A6NIU9
    • Q2YDB5
    • Q4VY06
    • Q7Z706

    Protein attributes for TRAF3IP3 Gene

    Size:
    551 amino acids
    Molecular mass:
    63626 Da
    Quaternary structure:
    • Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain.

    Alternative splice isoforms for TRAF3IP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3IP3 Gene

Proteomics data for TRAF3IP3 Gene at MOPED

Post-translational modifications for TRAF3IP3 Gene

  • Ubiquitination at Lys 267
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TRAF3IP3 Gene

Domains & Families for TRAF3IP3 Gene

Protein Domains for TRAF3IP3 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAF3IP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Function for TRAF3IP3 Gene

Molecular function for TRAF3IP3 Gene

UniProtKB/Swiss-Prot Function:
May function as an adapter molecule that regulates TRAF3-mediated JNK activation.
genes like me logo Genes that share phenotypes with TRAF3IP3: view

Animal Models for TRAF3IP3 Gene

MGI Knock Outs for TRAF3IP3:

Animal Model Products

CRISPR Products

miRNA for TRAF3IP3 Gene

miRTarBase miRNAs that target TRAF3IP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF3IP3 Gene

Localization for TRAF3IP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF3IP3 Gene COMPARTMENTS Subcellular localization image for TRAF3IP3 gene
Compartment Confidence
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TRAF3IP3 Gene

Pathways & Interactions for TRAF3IP3 Gene

SuperPathways for TRAF3IP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAF3IP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAF3IP3 Gene

Drugs & Compounds for TRAF3IP3 Gene

No Compound Related Data Available

Transcripts for TRAF3IP3 Gene

Unigene Clusters for TRAF3IP3 Gene

TRAF3 interacting protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16 ^
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: - - -
SP7: -
SP8: - - -
SP9: -
SP10: -
SP11:
SP12:
SP13:

ExUns: 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for TRAF3IP3 Gene

GeneLoc Exon Structure for
TRAF3IP3
ECgene alternative splicing isoforms for
TRAF3IP3

Expression for TRAF3IP3 Gene

mRNA expression in normal human tissues for TRAF3IP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAF3IP3 Gene

This gene is overexpressed in Whole Blood (x20.7), Spleen (x6.5), and Small Intestine - Terminal Ileum (x4.0).

Protein differential expression in normal tissues from HIPED for TRAF3IP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.6), Lymph node (9.2), and Pancreas (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF3IP3 Gene



SOURCE GeneReport for Unigene cluster for TRAF3IP3 Gene Hs.147434

genes like me logo Genes that share expression patterns with TRAF3IP3: view

Protein tissue co-expression partners for TRAF3IP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRAF3IP3 Gene

Orthologs for TRAF3IP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3IP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAF3IP3 35
  • 87.17 (n)
  • 84.57 (a)
TRAF3IP3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3IP3 35
  • 88.5 (n)
  • 87.41 (a)
TRAF3IP3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3ip3 35
  • 82.91 (n)
  • 76.53 (a)
Traf3ip3 16
Traf3ip3 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAF3IP3 35
  • 99.09 (n)
  • 98.55 (a)
TRAF3IP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf3ip3 35
  • 81.33 (n)
  • 75.15 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAF3IP3 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3IP3 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF3IP3 35
  • 57.94 (n)
  • 48.88 (a)
TRAF3IP3 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3IP3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145338 35
  • 51.52 (n)
  • 40.91 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534789 35
  • 43.78 (n)
  • 29.92 (a)
CR847543.1 36
  • 26 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17494 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M4.1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8207 36
  • 20 (a)
OneToMany
Species with no ortholog for TRAF3IP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3IP3 Gene

ENSEMBL:
Gene Tree for TRAF3IP3 (if available)
TreeFam:
Gene Tree for TRAF3IP3 (if available)

Paralogs for TRAF3IP3 Gene

Paralogs for TRAF3IP3 Gene

(2) SIMAP similar genes for TRAF3IP3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRAF3IP3: view

Variants for TRAF3IP3 Gene

Sequence variations from dbSNP and Humsavar for TRAF3IP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs669694 - 209,777,415(+) ACCAG(C/G)AACTG intron-variant, nc-transcript-variant, reference, missense
VAR_035664 A colorectal cancer sample
rs611861 -- 209,763,906(-) ATTTA(C/G)CATAT intron-variant
rs648349 -- 209,777,141(+) TATCA(A/G)AAGTC intron-variant
rs649275 -- 209,777,336(+) GGCCC(C/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP3 Gene

Variant ID Type Subtype PubMed ID
nsv873139 CNV Gain 21882294
nsv4343 CNV Loss 18451855
esv2722162 CNV Deletion 23290073
esv2722173 CNV Deletion 23290073
nsv159698 CNV Loss 16902084
esv2722184 CNV Deletion 23290073
esv2491231 CNV Deletion 19546169
esv2722195 CNV Deletion 23290073

Variation tolerance for TRAF3IP3 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF3IP3 Gene

HapMap Linkage Disequilibrium report
TRAF3IP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP3 Gene

Disorders for TRAF3IP3 Gene

Relevant External Links for TRAF3IP3

Genetic Association Database (GAD)
TRAF3IP3
Human Genome Epidemiology (HuGE) Navigator
TRAF3IP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF3IP3

No disorders were found for TRAF3IP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRAF3IP3 Gene

Publications for TRAF3IP3 Gene

  1. T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). (PMID: 14572659) Dadgostar H. … Cheng G. (FEBS Lett. 2003) 2 3 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3
  4. TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3. (PMID: 23376921) Boada-Romero E. … Pimentel-Muinos F.X. (EMBO J. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TRAF3IP3 Gene

Sources for TRAF3IP3 Gene

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