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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRAF3IP3 Gene

protein-coding GIFtS: 51
GCID: GC01P209929

TRAF3 interacting protein 3

Explore 5 diseases affiliated with
TRAF3IP3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TRAF3 Interacting Protein 3¹ ²
T3JAM¹ ² ³
TRAF3-Interacting Protein 3² ³
DJ434O14.3²
TRAF3 Interacting Jun N Terminal Kinase (JNK) Activating Modulator²
TRAF3-Interacting JNK-Activating Modulator²

External Ids:	HGNC: 30766¹	Entrez Gene: 80342²	Ensembl: ENSG00000009790⁷	OMIM: 608255⁵	UniProtKB: Q9Y228³

Export aliases for TRAF3IP3 gene to outside databases

Previous GC identifers: GC01P206318 GC01P207996 GC01P180604

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF3IP3:

The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction

pathway. The encoded protein may also interact with a large multiprotein assembly containing the phosphatase 2A

catalytic subunit. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: T3JAM_HUMAN, Q9Y228

Function: May function as an adapter molecule that regulates TRAF3-mediated JNK activation (By similarity)

Gene Wiki entry for TRAF3IP3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRAF3IP3 gene promoter:
Pbx1a AML1a AP-1 ATF-2 NF-kappaB NF-kappaB2 c-Jun NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRAF3IP3 promoter sequence

Search SABiosciences Chromatin IP Primers for TRAF3IP3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3IP3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.2 HGNC cytogenetic band: 1q32.3-q41

TRAF3IP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3IP3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P209929: view genomic region (about GC identifiers)

Start:	209,929,377 bp from pter	End:	209,955,668 bp from pter
Size:	26,292 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T3JAM_HUMAN, Q9Y228 (See protein sequence)

Recommended Name: TRAF3-interacting JNK-activating modulator

Size: 551 amino acids; 63626 Da

Subunit: Binds to the isoleucine zipper of TRAF3 via its coiled-coil domain (By similarity)

Subcellular location: Membrane; Single-pass type IV membrane protein (Potential)

Secondary accessions: A1L464 A6NIU9 Q2YDB5 Q4VY06 Q7Z706

Alternative splicing: 3 isoforms: Q9Y228-1 Q9Y228-2 Q9Y228-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF3IP3: NX_Q9Y228

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y228

TRAF3IP3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_079504.2

ENSEMBL proteins:

ENSP00000383743 ENSP00000355992 ENSP00000417665 ENSP00000419180 ENSP00000355993

ENSP00000355991 ENSP00000355990 ENSP00000418906 ENSP00000417417 ENSP00000436982

ENSP00000010338

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	Uscn Proteins for TRAF3IP3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TRAF3IP3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9Y228

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: T3JAM_HUMAN, Q9Y228

Function: May function as an adapter molecule that regulates TRAF3-mediated JNK activation (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: TRAF3IP3 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18782753

TRAF3IP3 for ontologies About GeneDecksing

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Traf3ip3):

hematopoietic system

immune system

TRAF3IP3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRAF3IP3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/41 Interacting proteins for TRAF3IP3 (Q9Y228^{1, 2, 3} ENSP00000010338⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STK24	Q9Y6E0¹^,³, ENSP00000365730⁴	EBI-765817,EBI-1054809 I2D: score=2 STRING: ENSP00000365730
STRIP1	Q5VSL9¹^,³, ENSP00000358810⁴	EBI-765817,EBI-1773588 I2D: score=2 STRING: ENSP00000358810
STRN	O43815¹^,³, ENSP00000263918⁴	EBI-765817,EBI-1046642 I2D: score=2 STRING: ENSP00000263918
FAM40A	Q5VSL9¹^,³	EBI-765817,EBI-1773588 I2D: score=2
MOB4	Q9Y3A3¹^,³, ENSP00000315702⁴	EBI-765817,EBI-713935 I2D: score=2 STRING: ENSP00000315702

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRAF3IP3
Search CenterWatch for drugs/clinical trials and news about TRAF3IP3 / T3JAM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRAF3IP3 gene:

NM_025228.2

Unigene Cluster for TRAF3IP3:

TRAF3 interacting protein 3

Hs.147434 [show with all ESTs]

Unigene Representative Sequence: AK126139

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400959 ENST00000367025(uc001hho.3 uc001hhn.3) ENST00000478359(uc001hhm.2)

ENST00000479796 ENST00000468672 ENST00000367026 ENST00000367024(uc009xcr.3)

ENST00000367023 ENST00000476050 ENST00000487271 ENST00000474496 ENST00000477431

ENST00000480569 ENST00000488702 ENST00000471368 ENST00000460314 ENST00000467830

ENST00000010338

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Additional cDNA sequence:

AK092905.1 AK122792.1 AK125601.1 AK126139.1 AK225762.1 AK300555.1 AK312755.1 AL049667.1

BC110302.1 BC130417.1 BC144139.1 BX648450.1

17 DOTS entries:

DT.95265528 DT.101981376 DT.104872 DT.91761002 DT.101981375 DT.40122829 DT.92402538 DT.100729701

DT.86849076 DT.99950605 DT.40305684 DT.75196526 DT.100754168 DT.95257015 DT.95336021 DT.75167579

DT.92041204

24/111 AceView cDNA sequences (see all 111):

AI382035 CR603000 CA436636 AU100107 AA872549 AI417006 AA911785 AL040817

Z32860 AA825845 BI907753 AU107252 BP346300 AL049667 BQ004970 NM_025228

AW872837 BU753878 BX648450 CR609673 BU617507 BG755379 AI762541 BU595249

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP3 (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	·	15c	^	16	^
SP1:																									-		-		-				-								-		-
SP2:																									-		-		-				-								-		-		-		-		-
SP3:																																	-								-		-
SP4:																																	-								-		-								-
SP5:

ExUns:	17a	·	17b	·	17c	^	18	^	19a	·	19b	^	20a	·	20b
SP1:	-				-				-
SP2:	-
SP3:	-
SP4:	-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for TRAF3IP3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRAF3IP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTGTTGA

About this image

TRAF3IP3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Bone

Limb

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRAF3IP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF3IP3

SOURCE GeneReport for Unigene cluster: Hs.147434

SABiosciences Custom PCR Arrays for TRAF3IP3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRAF3IP3 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRAF3IP3¹	TRAF3 interacting protein 3	62.8(n) 59.6(a)		419862 XM_417989.3 XP_417989.3
lizard (Anolis carolinensis)	Reptilia	TRAF3IP3⁶	--	44(a)	1 ↔ 1	4(126092794-126097613)
zebrafish (Danio rerio)	Actinopterygii	LOC100534789¹	TRAF3-interacting JNK-activating modulator-like	44.44(n) 30.45(a)		100534789 XM_003199090.1 XP_003199138.1

ENSEMBL Gene Tree for TRAF3IP3 (if available)
TreeFam Gene Tree for TRAF3IP3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRAF3IP3 gene

CCDC136² SLMAP²

2 SIMAP similar genes for TRAF3IP3 using alignment to 7 protein entries: T3JAM_HUMAN (see all proteins):

DKFZp586I031 SLMAP

TRAF3IP3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185944870^1,2		--	209927406(+)	`GTCTCA/GTGGGC`	1	--	us2k¹		0	--	--	--	--
rs190608217^1,2		--	209927425(+)	`ATAAGG/TTATAT`	1	--	us2k¹		0	--	--	--	--
rs113754717^1,2	C,	--	209927448(+)	`AGTTCTG/-TGTGT`	1	--	us2k¹		1		CSA	2
rs58583206^1,2	C	--	209927465(+)	`TGTGT-/GTCTTTT`	1	--	us2k¹		0	--	--	--	--
rs183180923^1,2		--	209927573(+)	`AACACC/TTTCTG`	1	--	us2k¹		0	--	--	--	--
rs11411152^1,2	C,	--	209927648(+)	`GCGGAG/-CTTTG`	1	--	us2k¹		2		CSA	4
rs72504315^1,2	C,	--	209927648(+)	`GCGGA-/GACTTT`	1	--	us2k¹		0	--	--	--	--
rs6540552^1,2	C,F,A,H,	--	209927710(+)	`AGGAAT/CTCCTA`	1	--	us2k¹		11		NA WA CSA EA	378
rs12075595^1,2	C,F,	--	209927822(+)	`ATGCCC/TGTGAT`	1	--	us2k¹		7		NA WA CSA	12
rs187944361^1,2		--	209927827(+)	`TGTGAC/TCGCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRAF3IP3 (209929377 - 209955668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TRAF3IP3
3 Indels: 97622 39679 11431

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF3IP3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRAF3IP3 for disorders           About GeneDecksing

OMIM gene information: 608255    OMIM disorders: --

5 diseases for TRAF3IP3:    About MalaCards

cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 rectum cancer

cerebritis

1 disease from the University of Copenhagen DISEASES database for TRAF3IP3:

Rectum cancer

Human Genome Epidemiology (HuGE) Navigator: TRAF3IP3 (1 document)

Export disorders for TRAF3IP3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRAF3IP3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TRAF3IP3)

Utopia: connect your pdf to the dynamic
world of online information

T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). (PubMed id 14572659)^{1, 3, 9} Dadgostar H....Cheng G. (2003)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{1, 2} Vasilescu J.... Figeys D. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein. (PubMed id 18782753)¹ Goudreault M....Gingras A.C. (2009)
Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library. (PubMed id 17868742)¹ Ma X....Ma D. (2007)
TRAF3 interacts with Smac/DIABLO and enhances the proapoptotic effect of Smac/DIABLO in cytoplasm. (PubMed id 17277885)¹ Zhang C....Wang Y. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Analysis of BCL6-interacting proteins by tandem mass spectrometry. (PubMed id 16147992)¹ Miles R.R....Elenitoba-Johnson K.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80342	HGNC: 30766	AceView: T3JAM	Ensembl:ENSG00000009790	euGenes: HUgn80342
ECgene: TRAF3IP3	H-InvDB: TRAF3IP3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRAF3IP3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRAF3IP3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRAF3IP3 gene:
Search GeneIP for patents involving TRAF3IP3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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