Aliases for TRAF3IP2 Gene
External Ids for TRAF3IP2 Gene
Previous HGNC Symbols for TRAF3IP2 Gene
Previous GeneCards Identifiers for TRAF3IP2 Gene
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for TRAF3IP2 Gene
TRAF3IP2 (TRAF3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TRAF3IP2 include Candidiasis, Familial, 8 and Psoriasis Susceptibility 13. Among its related pathways are IL-17 Family Signaling Pathways and Cytokine production by Th17 cells in CF (Mouse model).
UniProtKB/Swiss-Prot for TRAF3IP2 Gene
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK.