Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF3IP2 Gene

protein-coding   GIFtS: 60
GCID: GC06M111877

TRAF3 interacting protein 2

(Previous names: chromosome 6 open reading frame 5, chromosome 6 open reading...)
(Previous symbols: C6orf4, C6orf5, C6orf6, C6orf2)
 Explore 8 diseases affiliated with
TRAF3IP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRAF3IP2    

Aliases
for TRAF3IP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRAF3 Interacting Protein 21 2     Nuclear Factor NF-Kappa-B Activator 12 3
ACT11 2 3 5     DKFZP586G05221
C6orf41 2 3 5     Chromosome 6 Open Reading Frame 21
C6orf51 2 3 5     Chromosome 6 Open Reading Frame 51
C6orf61 2 3 5     PSORS132
C6orf21 2 3     Adapter Protein CIKS2
CIKS1 2 5     NFkB-Activating Protein ACT12
Connection To IKK And SAPK/JNK2 3     TRAF3-Interacting Protein 23

External Ids:    HGNC: 13431   Entrez Gene: 107582   Ensembl: ENSG000000569727   OMIM: 6070435   UniProtKB: O437343   
ORGUL members:         
NONCODE:n408194    

Export aliases for TRAF3IP2 gene to outside databases

Previous GC identifers: GC06M111985 GC06M111986 GC06M109452


Summaries
for TRAF3IP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRAF3IP2:
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription
factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and
stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either
I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding
different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the
opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at
least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.
(provided by RefSeq, Aug 2009)

UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
Function: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent
mechanism and stress-activated protein kinase (SAPK)/JNK

Gene Wiki entry for TRAF3IP2


Genomic Views
for TRAF3IP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF3IP2 gene promoter:
         TBP   NF-1   FOXC1   COMP1   SEF-1 (1)   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRAF3IP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF3IP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3IP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

TRAF3IP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3IP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111877:  view genomic region     (about GC identifiers)

Start:
 111,877,657 bp from pter      End:
 111,927,481 bp from pter
Size:
 49,825 bases      Orientation:
 minus strand

Proteins
for TRAF3IP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734 (See protein sequence)
Recommended Name: Adapter protein CIKS  
Size: 574 amino acids; 64666 Da
Subunit: Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts
with TRAF6
Sequence caution: Sequence=BAB15507.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RAY9 E1P555 Q5R3A3 Q7Z6Q2 Q7Z6Q3 Q9H5W2 Q9H6Y3 Q9NS14 Q9UG72
Alternative splicing: 4 isoforms:  O43734-1   O43734-2   O43734-3   O43734-4   

Explore the universe of human proteins at neXtProt for TRAF3IP2: NX_O43734

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43734

    • TRAF3IP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157753.1  NP_001157755.1  NP_679211.2  

    ENSEMBL proteins: 
     ENSP00000357750   ENSP00000352889   ENSP00000345984   ENSP00000357724   ENSP00000376339  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TRAF3IP2
    OriGene Custom Protein Services for TRAF3IP2 
    GenScript Custom Purified and Recombinant Proteins Services for TRAF3IP2
    Novus Biologicals TRAF3IP2 Proteins
    Novus Biologicals TRAF3IP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRAF3IP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----


    TRAF3IP2 for ontologies           About GeneDecksing



    TRAF3IP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): TRAF3IP2
    OriGene Custom Antibody Services for TRAF3IP2 
    GenScript Custom Superior Antibodies Services for TRAF3IP2
    Novus Biologicals TRAF3IP2 Antibodies
    Abcam antibodies for TRAF3IP2 
    Uscn Antibodies for TRAF3IP2
    ThermoFisher Antibodies for TRAF3IP2

    Assay Products for TRAF3IP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAF3IP2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TRAF3IP2

    Protein Domains /
    Families
    for TRAF3IP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRAF3IP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry O43734

    ProtoNet protein and cluster: O43734

    1 Blocks protein family: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
    Similarity: Contains 1 SEFIR domain


    Function
    for TRAF3IP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
    Function: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent
    mechanism and stress-activated protein kinase (SAPK)/JNK

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): TRAF3IP2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF3IP2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF3IP2:
    hsa-miR-520d-5p hsa-miR-493* hsa-let-7g* hsa-miR-524-5p hsa-let-7a-2* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmid: TRAF3IP2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF3IP2 (see all 7)
    OriGene shRNA RFP: TRAF3IP2
    OriGene siRNA: TRAF3IP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF3IP2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRAF3IP2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3IP2 (NM_147686)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF3IP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3IP2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRAF3IP2
    Search LifeMap BioReagents cell lines for TRAF3IP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12459498


    TRAF3IP2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRAF3IP2:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for TRAF3IP2: Traf3ip2tm1Sbn Traf3ip2tm1.1Lix
         13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Traf3ip2):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     hematopoietic system  immune system  integument  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  vision/eye 

    TRAF3IP2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRAF3IP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    		Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    		Cytokine production by Th17 cells in CF (Mouse model)0.37
    		Cytokine production by Th17 cells in CF0.45
    2Selected targets of C/EBPbeta
    		Selected targets of C/EBPbeta1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TRAF3IP2
        Selected targets of C/EBPbeta


    3 GeneGo (Thomson Reuters) Pathways for TRAF3IP2
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways



    TRAF3IP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF3IP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/21 Interacting proteins for TRAF3IP2 (O437342, 3 ENSP000003459844) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502, 3, ENSP000002303214MINT-67046 I2D: score=4 STRING: ENSP00000230321
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    IL17RAQ96F463, ENSP000003209364I2D: score=2 STRING: ENSP00000320936
    MAP3K7O433183, ENSP000003583354I2D: score=2 STRING: ENSP00000358335
    IL17AQ165523, ENSP000003441924I2D: score=1 STRING: ENSP00000344192
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001783B cell apoptotic process IEA--
    GO:0006959humoral immune response IEA--
    GO:0035556intracellular signal transduction NAS10962033
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IEP12761501
    GO:0048305immunoglobulin secretion IEA--


    TRAF3IP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRAF3IP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF3IP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF3IP2
    3 Novoseek chemical compound relationships for TRAF3IP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 3-phosphate 45.3 1 14615603 (1)
    xylose 32 1 12230228 (1)
    salicylic acid 23.6 1 14615603 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAF3IP2 / CIKS 

    Transcripts
    for TRAF3IP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRAF3IP2 gene (5 alternative transcripts): 
    NM_001164281.2  NM_001164283.2  NM_147686.3  NM_001164282.1  NM_147200.1  

    Unigene Clusters for TRAF3IP2:

    TRAF3 interacting protein 2
    Hs.561514  [show with all ESTs], Hs.740602  [show with all ESTs]
    Unigene Representative Sequences: NR_028338, BM807606
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368761 ENST00000359831 ENST00000340026 ENST00000492671 ENST00000368731(uc003pvd.3)
    ENST00000368735(uc011ebb.2) ENST00000368734 ENST00000368730 ENST00000464903
    ENST00000532708 ENST00000528599 ENST00000392556(uc003pvg.3 uc011ebc.2 uc003pvf.3 uc010kdw.3 uc010kdx.2)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TRAF3IP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF3IP2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF3IP2:
    hsa-miR-520d-5p hsa-miR-493* hsa-let-7g* hsa-miR-524-5p hsa-let-7a-2* hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmid: TRAF3IP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF3IP2 (see all 7)
    OriGene shRNA RFP: TRAF3IP2
    OriGene siRNA: TRAF3IP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF3IP2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3IP2 (NM_147686)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF3IP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3IP2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF3IP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF3IP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF3IP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF3IP2

    Additional cDNA sequence: AF085921.1 

    19 DOTS entries:

    DT.95137875  DT.100793416  DT.100844815  DT.95137916  DT.121340111  DT.444994  DT.97847465  DT.100642102 
    DT.121340282  DT.100793417  DT.100793418  DT.86835899  DT.100638053  DT.121340113  DT.121340330  DT.92033597 
    DT.95121258  DT.75175437  DT.91952719 

    24/284 AceView cDNA sequences (see all 284):

    CD369631 AW513823 NM_147200 AK025351 CA444825 BC026723 AI537025 BM747430 
    BM662773 BQ677434 AA424886 CR611078 BQ059333 AW953378 CD637491 BG576971 
    AI190495 AA336626 AI799587 AI571216 AW593560 AI203534 CN480792 AF274303 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                            -           -                                         -                 -     -     -     -                     
    SP2:                                            -     -     -                                         -                 -     -     -     -                     
    SP3:                                            -     -     -                                         -                 -     -     -     -                     
    SP4:                                                                                                                    -     -     -     -                     
    SP5:                                                                                                                                -     -                     

    ExUns: 15b · 15c · 15d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TRAF3IP2

    Expression
    for TRAF3IP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF3IP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACCCAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TRAF3IP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF3IP2

    SOURCE GeneReport for Unigene clusters: Hs.561514 Hs.740602

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for TRAF3IP2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF3IP2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF3IP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF3IP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF3IP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP2

    Orthologs
    for TRAF3IP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRAF3IP2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Traf3ip21 , 5 TRAF3 interacting protein 21, 5 85.64(n)1
    82.3(a)1    		   10 (20.86 cM)5
    1032131  NM_134000.31  NP_598761.21 
     396129345 
    chicken
    (Gallus gallus)    		 Aves TRAF3IP21 TRAF3 interacting protein 2 65.18(n)
    61.17(a)    		   421752  XM_419782.2  XP_419782.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TRAF3IP26
    		 --
    		 53(a)
    		 1 ↔ 1
    		 1(192290020-192327156)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.39452 Transcribed sequence with weak similarity to protein more 75.59(n)    AL873915.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii CR548641.16
    CABZ01080457.16
    (see all 3)    		 --
    		 51(a)
    31(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 6(36844509-36845091)
    11(45224600-45234949)


    ENSEMBL Gene Tree for TRAF3IP2 (if available)
    TreeFam Gene Tree for TRAF3IP2 (if available) 

    Paralogs
    for TRAF3IP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TRAF3IP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/849 NCBI SNPs in TRAF3IP2 are shown (see all 849)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1114960511,2
    		C,--109450016(+) ATCACA/GTTGCT 4 -- nc-transcript-variantut312Minor allele frequency- G:0.04CSA WA 120
    rs412898941,2
    		C,--109450329(+) CCCAGC/TAGACA 4 -- nc-transcript-variantut310--------
    rs564106561,2
    		--109452335(+) CCTCCC/TGGGTT 4 -- nc-transcript-variantut310--------
    rs94876691,2
    		C,F,H,--109452693(+) AAGCAA/GCTGCC 4 -- nc-transcript-variantut3114Minor allele frequency- G:0.09NS EA NA WA 1938
    rs412898961,2
    		C,F,--109453438(+) CCCAAA/GCATTT 4 -- int11Minor allele frequency- G:0.03NA 120
    rs1133100561,2
    		C,--109454010(+) TTAAAC/TGGGGT 4 -- int12Minor allele frequency- T:0.03CSA WA 120
    rs1114821391,2
    		--109455155(+) CTGAGG/TCAGGA 4 -- int11Minor allele frequency- T:0.50CSA 2
    rs775949671,2
    		--109455377(+) CAAAGA/GCACAG 4 -- int10--------
    rs737676031,2
    		C,F,--109455489(+) GACACA/TGTCCT 4 -- int13Minor allele frequency- T:0.10WA CSA 122
    rs131909771,2
    		H--109455774(+) ACAGCC/TTGAGG 4 -- int14Minor allele frequency- T:0.00NS EA 420

    HapMap Linkage Disequilibrium report for TRAF3IP2 (111877657 - 111927481 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRAF3IP2: --
    Human Gene Mutation Database (HGMD): TRAF3IP2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF3IP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF3IP2

    Disorders / Diseases
    for TRAF3IP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRAF3IP2 for disorders           About GeneDecksing

    OMIM gene information: 607043    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
  • Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13) [MIM:614070]. PSORS13 is a
    • common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly
    plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation
    and infiltration of inflammatory cells into the dermis and epidermis

    8 diseases for TRAF3IP2:    About MalaCards
    inflammatory bowel disease    psoriatic arthritis    sjogren's syndrome    parkinson's disease
    alzheimer's disease    arthritis    psoriasis    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for TRAF3IP2:
    Psoriasis     Psoriatic arthritis

    3 Novoseek disease relationships for TRAF3IP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 22.4 1 12759449 (1)
    necrosis 15.4 5 19244213 (1), 12459498 (1), 12706892 (1), 10962033 (1)
    tumors 0 5 19244213 (1), 12459498 (1), 12706892 (1), 10962033 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRAF3IP2 (4 documents)

    Export disorders for TRAF3IP2 gene to outside databases

    Publications
    for TRAF3IP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF3IP2 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with TRAF3IP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Act1, an NF-kappa B-activating protein. (PubMed id 10962024)1, 2, 3, 9 Li X.... Stark G.R. (2000)
    2. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. (PubMed id 10962033)1, 2, 3, 9 Leonardi A.... Siebenlist U. (2000)
    3. NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. (PubMed id 12459498)1, 2, 9 Kanamori M....Suzuki H. (2002)
    4. Common variants at TRAF3IP2 are associated with susce ptibility to psoriatic arthritis and psoriasis. (PubMed id 20953186)1, 2 HA1ffmeier U....Reis A. (2010)
    5. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. (PubMed id 20953188)1, 2 Ellinghaus E....Franke A. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. (PubMed id 10903453)1, 2 Morelli C....Barbanti-Brodano G. (2000)
    10. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. (PubMed id 17277779)1, 9 Qian Y....Li X. (2007)

    External Searches for TRAF3IP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRAF3IP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10758 HGNC: 1343 AceView: C6orf4 Ensembl:ENSG00000056972 euGenes: HUgn10758
    ECgene: TRAF3IP2 H-InvDB: TRAF3IP2

    Other Databases showing TRAF3IP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRAF3IP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF3IP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF3IP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TRAF3IP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRAF3IP2 gene:
    Search GeneIP for patents involving TRAF3IP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TRAF3IP2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TRAF3IP2   OriGene shRNA RFP for TRAF3IP2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF3IP2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF3IP2  
     OriGene Protein Over-expression Lysate for TRAF3IP2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TRAF3IP2   OriGene 3'-UTR Clone for TRAF3IP2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRAF3IP2   OriGene Custom Protein Services for TRAF3IP2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRAF3IP2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF3IP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3IP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRAF3IP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF3IP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF3IP2
     GenScript Custom Purified and Recombinant Proteins Services for TRAF3IP2 GenScript cDNA clones with any tag delivered in your preferred vector for TRAF3IP2
     GenScript Custom Assay Services for TRAF3IP2 GenScript Custom Superior Antibodies Services for TRAF3IP2
     GenScript Custom overexpressing Cell Line Services for TRAF3IP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRAF3IP2 promoter
     Search Chromatin IP Primers for TRAF3IP2
     RT2 qPCR Primer Assay in human, mouse, rat TRAF3IP2
     GNC Network for TRAF3IP2
     SABiosciences Custom PCR Arrays for TRAF3IP2
     Search Tocris compounds for TRAF3IP2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRAF3IP2 antibodies
     TRAF3IP2 proteins
     TRAF3IP2 lysates
     Antibodies for TRAF3IP2
     See all of Abcam's Antibodies, Kits and Proteins for TRAF3IP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TRAF3IP2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TRAF3IP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP2
     SwitchGear 3'UTR luciferase reporter plasmids for TRAF3IP2
     SwitchGear Promoter luciferase reporter plasmids for TRAF3IP2
     ThermoFisher Antibodies for TRAF3IP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3IP2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TRAF3IP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4