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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF3IP2 Gene

protein-coding   GIFtS: 64
GCID: GC06M111877

TRAF3 Interacting Protein 2

(Previous names: chromosome 6 open reading frame 5, chromosome 6 open reading...)
(Previous symbols: C6orf4, C6orf5, C6orf6, C6orf2)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TRAF3 Interacting Protein 21 2     CIKS2 5
C6orf41 2 3 5     Chromosome 6 Open Reading Frame 21
C6orf51 2 3 5     Chromosome 6 Open Reading Frame 51
C6orf61 2 3 5     PSORS132
C6orf21 2 3     Adapter Protein CIKS2
ACT12 3 5     NFkB-Activating Protein ACT12
Connection To IKK And SAPK/JNK2 3     TRAF3-Interacting Protein 23
Nuclear Factor NF-Kappa-B Activator 12 3     

External Ids:    HGNC: 13431   Entrez Gene: 107582   Ensembl: ENSG000000569727   OMIM: 6070435   UniProtKB: O437343   
ORGUL members:         
NONCODE14:n408194      

Export aliases for TRAF3IP2 gene to outside databases

Previous GC identifers: GC06M111985 GC06M111986 GC06M109452


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF3IP2 Gene:
This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB
transcription factor family. These factors play a central role in innate immunity in response to pathogens,
inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor
receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does
not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this
transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it
has a regulatory role in the expression of this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for TRAF3IP2 Gene: 
TRAF3IP2 (TRAF3 interacting protein 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TRAF3IP2 include psoriatic arthritis, and sjogren's syndrome, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and Cytokine production by Th17 cells in CF. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
Function: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent
mechanism and stress-activated protein kinase (SAPK)/JNK

Gene Wiki entry for TRAF3IP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF3IP2 gene promoter:
         TBP   NF-1   FOXC1   COMP1   SEF-1 (1)   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRAF3IP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF3IP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3IP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

TRAF3IP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3IP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M111877:  view genomic region     (about GC identifiers)

Start:
111,877,657 bp from pter      End:
111,927,481 bp from pter
Size:
49,825 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734 (See protein sequence)
Recommended Name: Adapter protein CIKS  
Size: 574 amino acids; 64666 Da
Subunit: Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta.
Interacts with TRAF6
Sequence caution: Sequence=BAB15507.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RAY9 E1P555 Q5R3A3 Q7Z6Q1 Q7Z6Q2 Q7Z6Q3 Q9H5W2 Q9H6Y3 Q9NS14 Q9UG72
Alternative splicing: 5 isoforms:  O43734-1   O43734-2   O43734-3   O43734-4   O43734-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF3IP2: NX_O43734

Explore proteomics data for TRAF3IP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43734

  • TRAF3IP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAF3IP2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001157753.1  NP_001157755.1  NP_679211.2  

    ENSEMBL proteins: 
     ENSP00000357750   ENSP00000352889   ENSP00000345984   ENSP00000357724   ENSP00000376339  

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    Cloud-Clone Corp. Proteins for TRAF3IP2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    TRAF3IP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013568 SEFIR

    Graphical View of Domain Structure for InterPro Entry O43734

    ProtoNet protein and cluster: O43734

    1 Blocks protein domain: IPB013568 SEFIR

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
    Similarity: Contains 1 SEFIR domain


    TRAF3IP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIKS_HUMAN, O43734
    Function: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent
    mechanism and stress-activated protein kinase (SAPK)/JNK

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12459498
         
    TRAF3IP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRAF3IP2:
     Increased gamma-H2AX phosphory 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Traf3ip2):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     hematopoietic system  immune system  integument  mortality/aging  renal/urinary system 
     reproductive system  respiratory system  vision/eye 

    TRAF3IP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF3IP2: Traf3ip2tm1Sbn Traf3ip2tm1.1Lix

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF3IP2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF3IP2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRAF3IP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    IL-17 Signaling0.48
    2Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF0.72
    Cytokine production by Th17 cells in CF (Mouse model)0.72
    3Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TRAF3IP2
        Selected targets of C/EBPbeta

    1 R&D Systems Pathway for TRAF3IP2
        IL-17 Signaling


    3 GeneGo (Thomson Reuters) Pathways for TRAF3IP2
        Cytokine production by Th17 cells in CF (Mouse model)
    Cytokine production by Th17 cells in CF
    Mucin expression in CF via IL-6, IL-17 signaling pathways



    TRAF3IP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF3IP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/21 Interacting proteins for TRAF3IP2 (O437342, 3 ENSP000003459844) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502, 3, ENSP000002303214MINT-67046 I2D: score=4 STRING: ENSP00000230321
    CHUKO151113, ENSP000003594244I2D: score=2 STRING: ENSP00000359424
    IL17RAQ96F463, ENSP000003209364I2D: score=2 STRING: ENSP00000320936
    MAP3K7O433183, ENSP000003583354I2D: score=2 STRING: ENSP00000358335
    IL17AQ165523, ENSP000003441924I2D: score=1 STRING: ENSP00000344192
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001783B cell apoptotic process IEA--
    GO:0006959humoral immune response IEA--
    GO:0007165signal transduction ----
    GO:0035556intracellular signal transduction NAS10962033
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade IEP12761501

    TRAF3IP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF3IP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF3IP2 (CIKS)

    3 Novoseek inferred chemical compound relationships for TRAF3IP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycerol 3-phosphate 45.3 1 14615603 (1)
    xylose 32 1 12230228 (1)
    salicylic acid 23.6 1 14615603 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAF3IP2 / CIKS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF3IP2 gene (5 alternative transcripts): 
    NM_001164281.2  NM_001164283.2  NM_147686.3  NM_001164282.1  NM_147200.1  

    Unigene Clusters for TRAF3IP2:

    TRAF3 interacting protein 2
    Hs.561514  [show with all ESTs], Hs.740602  [show with all ESTs]
    Unigene Representative Sequences: NR_028338, BM807606
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368761 ENST00000359831 ENST00000340026 ENST00000492671 ENST00000368731(uc003pvd.3)
    ENST00000368735(uc011ebb.2) ENST00000368734 ENST00000368730 ENST00000464903
    ENST00000532708 ENST00000528599 ENST00000392556(uc003pvg.3 uc011ebc.2 uc003pvf.3 uc010kdw.3 uc010kdx.2)


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    Additional mRNA sequence: AF085921.1 

    19 DOTS entries:

    DT.95137875  DT.100793416  DT.100844815  DT.95137916  DT.121340111  DT.444994  DT.97847465  DT.100642102 
    DT.121340282  DT.100793417  DT.100793418  DT.86835899  DT.100638053  DT.121340113  DT.121340330  DT.92033597 
    DT.95121258  DT.75175437  DT.91952719 

    24/284 AceView cDNA sequences (see all 284):

    AK025351 AL050289 BM747430 AU102850 AI799587 AI203534 CD369631 AA846148 
    CR615860 BI908146 CA444825 CR611078 AW513823 AW593560 NM_147686 BC002823 
    BQ064390 AI479961 AI499206 AA782756 BM747445 AK026602 AI537025 BM856199 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP2 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a ·
    SP1:                                            -           -                                         -                 -     -     -     -                     
    SP2:                                            -     -     -                                         -                 -     -     -     -                     
    SP3:                                            -     -     -                                         -                 -     -     -     -                     
    SP4:                                                                                                                    -     -     -     -                     
    SP5:                                                                                                                                -     -                     

    ExUns: 15b · 15c · 15d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TRAF3IP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF3IP2 expression in normal human tissues (normalized intensities)      TRAF3IP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACCCAACA
    TRAF3IP2 Expression
    About this image


    TRAF3IP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   

    See TRAF3IP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF3IP2

    SOURCE GeneReport for Unigene clusters: Hs.561514 Hs.740602

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRAF3IP2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf3ip21 , 5 TRAF3 interacting protein 21, 5 85.64(n)1
    82.3(a)1
      10 (20.86 cM)5
    1032131  NM_134000.31  NP_598761.21 
     396129345 
    chicken
    (Gallus gallus)
    Aves TRAF3IP21 TRAF3 interacting protein 2 65.18(n)
    61.17(a)
      421752  XM_419782.2  XP_419782.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF3IP26
    Uncharacterized protein
    51(a)
    1 ↔ 1
    1(192290020-192327156)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.39452 Transcribed sequence with weak similarity to protein more 75.59(n)    AL873915.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CR548641.16
    CABZ01080457.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    52(a)
    30(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    6(36844509-36845091)
    11(45224600-45234949)


    ENSEMBL Gene Tree for TRAF3IP2 (if available)
    TreeFam Gene Tree for TRAF3IP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1011 SNPs in TRAF3IP2 are shown (see all 1011)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339805001,2,4
    C,FPsoriasis 13 (PSORS13)4 --111911159(+) TTCATC/TAACCT 5 N D nc-transcript-variantmis17Minor allele frequency- T:0.10NA WA EU 6189
    rs563408281,2
    C--109496111(+) TTTTT-/T/TT  
            
    CTGTC
    3 -- int10--------
    rs756762511,2
    C,F--111874024(+) TGCTTT/GCTTTC 4 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1444218601,2
    --111874045(+) CCCGAC/TCTTTG 4 -- ds50010--------
    rs1866361941,2
    C--111874324(+) GTGGTA/GACAAT 4 -- ds50010--------
    rs1480080211,2
    --111874348(+) AAGTGA/GATGAG 4 -- ds50010--------
    rs1417060931,2
    C--111874462(+) GACTCC/TGAGAA 4 -- ds50010--------
    rs754326221,2
    C,F--111874594(+) GTACTG/AAGACC 4 -- nc-transcript-variantut312Minor allele frequency- A:0.03WA EA 238
    rs1901519801,2
    --111874696(+) AGGTAA/GGAACC 4 -- nc-transcript-variantut310--------
    rs1505330321,2
    --111874705(+) CCTAAC/TCTTGC 4 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for TRAF3IP2 (111877657 - 111927481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRAF3IP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732578CNV Deletion23290073
    esv2732577CNV Deletion23290073


    Human Gene Mutation Database (HGMD): TRAF3IP2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF3IP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607043    OMIM disorders: --

    UniProtKB/Swiss-Prot: CIKS_HUMAN, O43734
  • Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with
    multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees.
    These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the
    dermis and epidermis. Note=Disease susceptibility is associated with variations affecting the gene represented in
    this entry

  • 8 diseases for TRAF3IP2:    About MalaCards
    psoriatic arthritis    sjogren's syndrome    psoriasis    inflammatory bowel disease
    parkinson's disease    schizophrenia    arthritis    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for TRAF3IP2:
    Psoriatic arthritis     Psoriasis

    TRAF3IP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for TRAF3IP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 22.4 1 12759449 (1)
    necrosis 15.4 5 19244213 (1), 12459498 (1), 12706892 (1), 10962033 (1)
    tumors 0 5 19244213 (1), 12459498 (1), 12706892 (1), 10962033 (1)

    Genetic Association Database (GAD): TRAF3IP2
    Human Genome Epidemiology (HuGE) Navigator: TRAF3IP2 (4 documents)

    Export disorders for TRAF3IP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF3IP2 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with TRAF3IP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Act1, an NF-kappa B-activating protein. (PubMed id 10962024)1, 2, 3, 9 Li X.... Stark G.R. (2000)
    2. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. (PubMed id 10962033)1, 2, 3, 9 Leonardi A.... Siebenlist U. (2000)
    3. Common variants at TRAF3IP2 are associated with susce ptibility to psoriatic arthritis and psoriasis. (PubMed id 20953186)1, 2, 4 HA1ffmeier U....Reis A. (2010)
    4. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. (PubMed id 20953188)1, 2, 4 Ellinghaus E....Franke A. (2010)
    5. NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6. (PubMed id 12459498)1, 2, 9 Kanamori M....Suzuki H. (2002)
    6. A genome-wide association study identifies new psoria sis susceptibility loci and an interaction between HLA-C and ERAP1. (PubMed id 20953190)1, 4  ....Trembath R.C. (2010)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    10. Cloning and characterization of two overlapping genes in a subregion at 6q21 involved in replicative senescence and schizophrenia. (PubMed id 10903453)1, 2 Morelli C....Barbanti-Brodano G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10758 HGNC: 1343 AceView: C6orf4 Ensembl:ENSG00000056972 euGenes: HUgn10758
    ECgene: TRAF3IP2 H-InvDB: TRAF3IP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF3IP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF3IP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAF3IP2 gene:
    Search GeneIP for patents involving TRAF3IP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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