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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF3IP1 Gene

protein-coding   GIFtS: 47
GCID: GC02P239229

TNF receptor-associated factor 3 interacting protein 1

 Explore 4 diseases affiliated with
TRAF3IP1 via our new
 Human Malady Compendium 
Biological research products
for TRAF3IP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 3 Interacting Protein 11 2     DKFZP434F1241
MIPT31 2 3 5     Interleukin 13 Receptor Alpha 1-Binding Protein-12
MIP-T31 2 3     Microtubule Interacting Protein That Associates With TRAF32
Interleukin-13 Receptor Alpha 1-Binding Protein 12 3     Microtubule-Interacting Protein That Associates With TRAF32
Microtubule-Interacting Protein Associated With TRAF32 3     TRAF3-Interacting Protein 12

External Ids:    HGNC: 178611   Entrez Gene: 261462   Ensembl: ENSG000002041047   OMIM: 6073805   UniProtKB: Q8TDR03   

Export aliases for TRAF3IP1 gene to outside databases

Previous GC identifers: GC02P239516 GC02P239011 GC02P238893 GC02P231020


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MIPT3_HUMAN, Q8TDR0
Function: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced
STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF3IP1 gene promoter:
         AhR   Bach1   Pax-5   POU6F1 (c2)   Arnt   CREB   MEF-2A   deltaCREB   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF3IP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF3IP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3IP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

TRAF3IP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3IP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P239229:  view genomic region     (about GC identifiers)

Start:
239,229,082 bp from pter      End:
239,309,541 bp from pter
Size:
80,460 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MIPT3_HUMAN, Q8TDR0 (See protein sequence)
Recommended Name: TRAF3-interacting protein 1  
Size: 691 amino acids; 78632 Da
Subunit: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 (By similarity).
Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1
Subcellular location: Cytoplasm, cytoskeleton. Note=Microtubules
1 PDB 3D structure from and Proteopedia for TRAF3IP1:
2EQO (3D)    
Secondary accessions: Q6PCT1 Q7L8N9 Q9NRD6 Q9Y4Q1
Alternative splicing: 2 isoforms:  Q8TDR0-1   Q8TDR0-2   

Explore the universe of human proteins at neXtProt for TRAF3IP1: NX_Q8TDR0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TDR0

  • TRAF3IP1 Protein expression data from MOPED and PaxDb:    About this image 
    TRAF3IP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001132962.1  NP_056465.2  

    ENSEMBL proteins: 
     ENSP00000375851   ENSP00000362424   ENSP00000386648   ENSP00000375852  

    Human Recombinant Protein Products for TRAF3IP1: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRAF3IP1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    TRAF3IP1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRAF3IP1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRAF3IP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018799 TRAF3IP1

    Graphical View of Domain Structure for InterPro Entry Q8TDR0

    ProtoNet protein and cluster: Q8TDR0

    UniProtKB/Swiss-Prot: MIPT3_HUMAN, Q8TDR0
    Similarity: Belongs to the TRAF3IP1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIPT3_HUMAN, Q8TDR0
    Function: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced
    STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17043677
         
    TRAF3IP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAF3IP1:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Traf3ip1):
     cardiovascular system  embryogenesis  homeostasis/metabolism  limbs/digits/tail  mortality/aging 
     nervous system  vision/eye 

    TRAF3IP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRAF3IP1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTRAF3IP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Sirion Biotech Customized inducible overexpressing cell line services for TRAF3IP1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRAF3IP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for TRAF3IP1 (Q8TDR01, 3 ENSP000003624244) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-1104484,EBI-529989 I2D: score=3 STRING: ENSP00000355596
    IL13RA1P785521, 3, ENSP000003607304EBI-1104484,EBI-3918927 I2D: score=3 STRING: ENSP00000360730
    TRAF3Q131141, 3, ENSP000003324684EBI-1104484,EBI-357631 I2D: score=3 STRING: ENSP00000332468
    ABI2Q9NYB93, ENSP000002610174I2D: score=2 STRING: ENSP00000261017
    FRMD4AQ9P2Q23, ENSP000003500324I2D: score=2 STRING: ENSP00000350032
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF3IP1
    Search CenterWatch for drugs/clinical trials and news about TRAF3IP1 / MIPT3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF3IP1 gene (2 alternative transcripts): 
    NM_001139490.1  NM_015650.3  

    Unigene Cluster for TRAF3IP1:

    TNF receptor-associated factor 3 interacting protein 1
    Hs.631898  [show with all ESTs]
    Unigene Representative Sequence: NM_015650
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391993 ENST00000373327(uc002vye.3 uc002vyf.3) ENST00000409739
    ENST00000462122 ENST00000483951 ENST00000391994

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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF3IP1:
    hsa-miR-3163 hsa-miR-548am hsa-miR-548x hsa-miR-3613-3p hsa-miR-590-3p hsa-miR-497* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidTRAF3IP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF3IP1 (see all 7)
    OriGene shRNA RFP: TRAF3IP1
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3IP1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRAF3IP1 (NM_015650)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF3IP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3IP1 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF3IP1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF3IP1
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    Additional cDNA sequence: 

    AF230877.1 AF242456.1 AL080153.1 BC059174.1 

    7 DOTS entries:

    DT.431372  DT.100035539  DT.202844  DT.91885606  DT.97803160  DT.120994036  DT.75194649 

    24/65 AceView cDNA sequences (see all 65):

    AW069058 AI277907 BE781823 AI499243 BM727042 BQ018317 AI366813 CK725158 
    CB243230 BQ185199 AI356967 BX280107 BQ021220 AL080153 BU740524 BM563106 
    CA488496 BU741288 AF230877 AI383556 BG287415 BC059174 BP349953 AF242456 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF3IP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCTGAATG
    TRAF3IP1 Expression
    About this image
    See TRAF3IP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF3IP1

    SOURCE GeneReport for Unigene cluster: Hs.631898

    UniProtKB/Swiss-Prot: MIPT3_HUMAN, Q8TDR0
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3IP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF3IP1 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf3ip11 , 5 TRAF3 interacting protein 11, 5 77.87(n)1
    78.25(a)1
      1 (46.16 cM)5
    740191  NM_028718.21  NP_082994.11 
     914946685 
    chicken
    (Gallus gallus)
    Aves TRAF3IP11 NF receptor-associated factor 3 interacting protein 1 less 65.19(n)
    58.19(a)
      424029  XM_003641562.1  XP_003641610.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF3IP16
    --
    56(a)
    1 ↔ 1
    1(118772558-118792864)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635222 hypothetical protein MGC63522 77.15(n)   393572  BC056776.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32591 CG3259 43.96(n)
    31.87(a)
      41739  NM_142096.3  NP_650353.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dyf-111 Protein DYF-11 44.4(n)
    27.74(a)
      180421  NM_075748.2  NP_508149.1 


    ENSEMBL Gene Tree for TRAF3IP1 (if available)
    TreeFam Gene Tree for TRAF3IP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF3IP1 gene
    SREK12  LUC7L2  SRSF112  RSRC22  LUC7L32  ZC3H132  LUC7L22  PNISR2  
    RBM252  PRPF38B2  

    TRAF3IP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1517 NCBI SNPs in TRAF3IP1 are shown (see all 1517    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1876016301,2
    --239227195(+) AACTAC/TGCAAG 2 -- us2k10--------
    rs1929514371,2
    --239227203(+) AAGCCA/GGAAGT 2 -- us2k10--------
    rs1442414961,2
    --239227250(+) AACAGA/TCAGTC 2 -- us2k10--------
    rs1465792051,2
    --239227272(+) ACTTTC/TCTTTT 2 -- us2k10--------
    rs1847534181,2
    --239227371(+) ACCCCC/TGGGTT 2 -- us2k10--------
    rs1896269811,2
    --239227472(+) CAGGCG/TTTCAC 2 -- us2k10--------
    rs23408861,2
    C,A--239227500(-) GGAGTT/ATGAGA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs116897891,2
    C,F,H--239227533(+) CTCAGC/GCTCCC 2 -- us2k14Minor allele frequency- G:0.25NA 8
    rs1510041571,2
    --239227563(+) CGTGAA/GCCACT 2 -- us2k10--------
    rs116789701,2
    C,F,A,H--239227622(+) GTCACT/CCAGGC 2 -- us2k16Minor allele frequency- C:0.33NA CSA 12

    HapMap Linkage Disequilibrium report for TRAF3IP1 (239229082 - 239309541 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRAF3IP1: --
    Human Gene Mutation Database (HGMD): TRAF3IP1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRAF3IP1 for disorders           About GeneDecksing

    OMIM gene information: 607380    OMIM disorders: --

    4 diseases for TRAF3IP1:    About MalaCards
    bardet-biedl syndrome    hearing loss    schizophrenia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: TRAF3IP1 (3 documents)

    Export disorders for TRAF3IP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF3IP1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TRAF3IP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. (PubMed id 12935900)1, 2, 3, 9 Niu Y.... Kobayashi N. (2003)
    2. MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PubMed id 10791955)1, 2, 3 Ling L. and Goeddel D.V. (2000)
    3. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. (PubMed id 12812986)1, 2 Morris J.A.... Austin C.P. (2003)
    4. MIP-T3 is a negative regulator of innate type I IFN r esponse. (PubMed id 22079989)1 Ng M.H....Jin D.Y. (2011)
    5. GWAS findings for human iris patterns: associations wi th variants in genes that influence normal neuronal pattern development. (PubMed id 21835309)1 Larsson M....Medland S.E. (2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. The C-terminus of MIP-T3 protein is required for ubiq uitin-proteasome-mediated degradation in human cells. (PubMed id 21510943)1 Guo C.W....Kitazato K. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Proteomic analysis reveals novel binding partners of MIP-T3 in human cells. (PubMed id 20391533)1 Guo C.W....Kitazato K. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26146 HGNC: 17861 AceView: TRAF3IP1 Ensembl:ENSG00000204104 euGenes: HUgn26146
    ECgene: TRAF3IP1 H-InvDB: TRAF3IP1

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