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Aliases for TRAF3IP1 Gene

Aliases for TRAF3IP1 Gene

  • TNF Receptor-Associated Factor 3 Interacting Protein 1 2 3
  • MIPT3 3 4 6
  • Microtubule Interacting Protein That Associates With TRAF3 2 3
  • Microtubule-Interacting Protein Associated With TRAF3 3 4
  • Interleukin-13 Receptor Alpha 1-Binding Protein 1 3 4
  • Intraflagellar Transport Protein 54 Homolog 3 4
  • MIP-T3 3 4
  • IFT54 3 4
  • Microtubule-Interacting Protein That Associates With TRAF3 3
  • Interleukin 13 Receptor Alpha 1-Binding Protein-1 3
  • TRAF3-Interacting Protein 1 3

External Ids for TRAF3IP1 Gene

Summaries for TRAF3IP1 Gene

GeneCards Summary for TRAF3IP1 Gene

TRAF3IP1 (TNF Receptor-Associated Factor 3 Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for TRAF3IP1 Gene

  • Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3IP1 Gene

Genomics for TRAF3IP1 Gene

Genomic Location for TRAF3IP1 Gene

Start:
238,320,441 bp from pter
End:
238,400,900 bp from pter
Size:
80,460 bases
Orientation:
Plus strand

Genomic View for TRAF3IP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF3IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3IP1 Gene

Regulatory Elements for TRAF3IP1 Gene

Proteins for TRAF3IP1 Gene

  • Protein details for TRAF3IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDR0-MIPT3_HUMAN
    Recommended name:
    TRAF3-interacting protein 1
    Protein Accession:
    Q8TDR0
    Secondary Accessions:
    • Q6PCT1
    • Q7L8N9
    • Q9NRD6
    • Q9Y4Q1

    Protein attributes for TRAF3IP1 Gene

    Size:
    691 amino acids
    Molecular mass:
    78632 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT88 (By similarity). Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1.

    Three dimensional structures from OCA and Proteopedia for TRAF3IP1 Gene

    Alternative splice isoforms for TRAF3IP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3IP1 Gene

Proteomics data for TRAF3IP1 Gene at MOPED

Post-translational modifications for TRAF3IP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRAF3IP1 Gene

No data available for DME Specific Peptides for TRAF3IP1 Gene

Domains for TRAF3IP1 Gene

Gene Families for TRAF3IP1 Gene

HGNC:
  • IFT :Intraflagellar transport homologs

Protein Domains for TRAF3IP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAF3IP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDR0

UniProtKB/Swiss-Prot:

MIPT3_HUMAN
Family:
  • Belongs to the TRAF3IP1 family.:
    • Q8TDR0
genes like me logo Genes that share domains with TRAF3IP1: view

Function for TRAF3IP1 Gene

Molecular function for TRAF3IP1 Gene

UniProtKB/Swiss-Prot Function: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules.

Gene Ontology (GO) - Molecular Function for TRAF3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10791955
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with TRAF3IP1: view
genes like me logo Genes that share phenotypes with TRAF3IP1: view

miRNA for TRAF3IP1 Gene

miRTarBase miRNAs that target TRAF3IP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRAF3IP1 Gene

Localization for TRAF3IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3IP1 Gene

Cytoplasm, cytoskeleton. Cell projection, cilium. Note=Microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF3IP1 Gene COMPARTMENTS Subcellular localization image for TRAF3IP1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRAF3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
GO:0005930 axoneme IEA --
GO:0030992 intraciliary transport particle B ISS --
GO:0036064 ciliary basal body IEA --
genes like me logo Genes that share ontologies with TRAF3IP1: view

Pathways for TRAF3IP1 Gene

SuperPathways for TRAF3IP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAF3IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IMP 22079989
GO:0006996 organelle organization TAS --
GO:0021532 neural tube patterning IEA --
GO:0031076 embryonic camera-type eye development IEA --
GO:0031333 negative regulation of protein complex assembly IMP 22079989
genes like me logo Genes that share ontologies with TRAF3IP1: view

No data available for Pathways by source for TRAF3IP1 Gene

Transcripts for TRAF3IP1 Gene

Unigene Clusters for TRAF3IP1 Gene

TNF receptor-associated factor 3 interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3IP1 Gene

No ASD Table

Relevant External Links for TRAF3IP1 Gene

GeneLoc Exon Structure for
TRAF3IP1
ECgene alternative splicing isoforms for
TRAF3IP1

Expression for TRAF3IP1 Gene

mRNA expression in normal human tissues for TRAF3IP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF3IP1 Gene

SOURCE GeneReport for Unigene cluster for TRAF3IP1 Gene Hs.631898

mRNA Expression by UniProt/SwissProt for TRAF3IP1 Gene

Q8TDR0-MIPT3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with TRAF3IP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRAF3IP1 Gene

Orthologs for TRAF3IP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF3IP1 35
  • 99.01 (n)
  • 98.52 (a)
TRAF3IP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAF3IP1 35
  • 80.31 (n)
  • 79.03 (a)
TRAF3IP1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3IP1 35
  • 79.92 (n)
  • 74.42 (a)
TRAF3IP1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3ip1 35
  • 76.7 (n)
  • 75.12 (a)
Traf3ip1 16
Traf3ip1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAF3IP1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3IP1 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf3ip1 35
  • 80.54 (n)
  • 79.5 (a)
chicken
(Gallus gallus)
Aves TRAF3IP1 35
  • 64.75 (n)
  • 58.29 (a)
TRAF3IP1 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3IP1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia traf3ip1 35
  • 60.58 (n)
  • 54.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6522 35
zebrafish
(Danio rerio)
Actinopterygii traf3ip1 35
  • 62.29 (n)
  • 57.05 (a)
traf3ip1 36
  • 53 (a)
OneToOne
zgc63522 35
fruit fly
(Drosophila melanogaster)
Insecta CG3259 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dyf-11 36
  • 28 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11848 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TRAF3IP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3IP1 Gene

ENSEMBL:
Gene Tree for TRAF3IP1 (if available)
TreeFam:
Gene Tree for TRAF3IP1 (if available)

Paralogs for TRAF3IP1 Gene

No data available for Paralogs for TRAF3IP1 Gene

Variants for TRAF3IP1 Gene

Sequence variations from dbSNP and Humsavar for TRAF3IP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs471497 -- 238,393,256(+) GCTCA(C/T)TGTGG intron-variant
rs472613 -- 238,374,390(-) aacca(C/T)gatta intron-variant
rs501500 -- 238,383,014(-) GAGCC(C/T)GAGAG intron-variant
rs505646 -- 238,377,262(-) ggagg(C/T)cctgt intron-variant
rs509063 -- 238,387,059(-) GTGAC(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF3IP1 Gene

Variant ID Type Subtype PubMed ID
nsv3233 CNV Insertion 18451855
esv2669020 CNV Deletion 23128226
nsv876068 CNV Loss 21882294
esv1355575 CNV Insertion 17803354

Relevant External Links for TRAF3IP1 Gene

HapMap Linkage Disequilibrium report
TRAF3IP1
Human Gene Mutation Database (HGMD)
TRAF3IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3IP1 Gene

Disorders for TRAF3IP1 Gene

(1) University of Copenhagen DISEASES for TRAF3IP1 Gene

Relevant External Links for TRAF3IP1

Genetic Association Database (GAD)
TRAF3IP1
Human Genome Epidemiology (HuGE) Navigator
TRAF3IP1
genes like me logo Genes that share disorders with TRAF3IP1: view

No data available for UniProtKB/Swiss-Prot for TRAF3IP1 Gene

Publications for TRAF3IP1 Gene

  1. MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. (PMID: 12935900) Niu Y. … Kobayashi N. (FEBS Lett. 2003) 2 3 4 23
  2. MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PMID: 10791955) Ling L. … Goeddel D.V. (J. Biol. Chem. 2000) 2 3 4
  3. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. (PMID: 12812986) Morris J.A. … Austin C.P. (Hum. Mol. Genet. 2003) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development. (PMID: 21835309) Larsson M. … Medland S.E. (Am. J. Hum. Genet. 2011) 3 48

Products for TRAF3IP1 Gene

Sources for TRAF3IP1 Gene

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