Aliases for TRAF3IP1 Gene
External Ids for TRAF3IP1 Gene
Previous GeneCards Identifiers for TRAF3IP1 Gene
The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]
GeneCards Summary for TRAF3IP1 Gene
TRAF3IP1 (TRAF3 Interacting Protein 1) is a Protein Coding gene. Diseases associated with TRAF3IP1 include Senior-Loken Syndrome 9 and Senior-Loken Syndrome-1. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance. GO annotations related to this gene include microtubule binding.
UniProtKB/Swiss-Prot for TRAF3IP1 Gene
Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels (PubMed:26487268). Involved in ciliogenesis (By similarity).