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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF3 Gene

protein-coding   GIFtS: 69
GCID: GC14P103243

TNF Receptor-Associated Factor 3

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 31 2     CD40 Associated Protein 12
CAP-12 3     CD40 Binding Protein2
CAP12 3     CD40 Receptor Associated Factor 12
CRAF12 3     CD40BP3
LAP12 3     EC 6.3.2.-3
LMP1-Associated Protein 12 3     CD40 Receptor-Associated Factor 13
CD40bp2     CD40-Binding Protein3
IIAE52     

External Ids:    HGNC: 120331   Entrez Gene: 71872   Ensembl: ENSG000001313237   OMIM: 6018965   UniProtKB: Q131143   

Export aliases for TRAF3 gene to outside databases

Previous GC identifers: GC14P100636 GC14P097059 GC14P101233 GC14P102313 GC14P083420


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF3 Gene:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR)
superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the
activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta
receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta
ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and
several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several
alternatively spliced transcript variants encoding three distinct isoforms have been reported. (provided by
RefSeq, Dec 2010)

GeneCards Summary for TRAF3 Gene: 
TRAF3 (TNF receptor-associated factor 3) is a protein-coding gene. Diseases associated with TRAF3 include herpes simplex encephalitis 3, and pulmonary neuroendocrine tumor, and among its related super-pathways are RANK Signaling in Osteoclasts and DR3 Signaling. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in
the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and
interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune
responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3
ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked
ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits
TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits
non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14

Gene Wiki entry for TRAF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF3 gene promoter:
         AP-1   p53   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

TRAF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103243:  view genomic region     (about GC identifiers)

Start:
103,243,813 bp from pter      End:
103,377,837 bp from pter
Size:
134,025 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114 (See protein sequence)
Recommended Name: TNF receptor-associated factor 3  
Size: 568 amino acids; 64490 Da
Subunit: Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40,
TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP,
TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same
binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with
RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and
BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4,
TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr
virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14
Subcellular location: Cytoplasm (Probable). Endosome (By similarity). Mitochondrion. Note=Undergoes endocytosis
together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus
6/8 PDB 3D structures from and Proteopedia for TRAF3 (see all 8):
1FLK (3D)        1FLL (3D)        1KZZ (3D)        1L0A (3D)        1RF3 (3D)        1ZMS (3D)    
Secondary accessions: B7Z8C4 Q12990 Q13076 Q13947 Q6AZX1 Q9UNL1
Alternative splicing: 2 isoforms:  Q13114-1   Q13114-2   

Explore the universe of human proteins at neXtProt for TRAF3: NX_Q13114

Explore proteomics data for TRAF3 at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by
    TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing
    TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination
    during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both
    'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by
    OTUB1, OTUB2 and OTUD5
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13114

  • TRAF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAF3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001186356.1  NP_003291.2  NP_663777.1  NP_663778.1  

    ENSEMBL proteins: 
     ENSP00000454207   ENSP00000376500   ENSP00000445998   ENSP00000453623   ENSP00000332468  
     ENSP00000453031   ENSP00000453032   ENSP00000328003  
    Reactome Protein details: Q13114
    Human Recombinant Protein Products for TRAF3: 
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    OriGene Purified Protein for TRAF3
    OriGene Protein Over-expression Lysate for TRAF3
    OriGene MassSpec for TRAF3 
    OriGene Custom Protein Services for TRAF3
    GenScript Custom Purified and Recombinant Proteins Services for TRAF3
    Novus Biologicals TRAF3 Proteins
    Novus Biologicals TRAF3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRAF3 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005768endosome IEA--
    GO:0005829cytosol TAS--
    GO:0009898internal side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    TRAF3 for ontologies           About GeneDecksing



    TRAF3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAF3
    R&D Systems Antibodies for TRAF3 (TRAF-3)
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    LSBio Antibodies in human, mouse, rat for TRAF3 

    Assay Products for TRAF3: 
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    Cloud-Clone Corp. ELISAs for TRAF3 
    Cloud-Clone Corp. CLIAs for TRAF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR027128 TRAF3
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q13114

    ProtoNet protein and cluster: Q13114

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic
    processing (By similarity)
    Similarity: Belongs to the TNF receptor-associated factor family. A subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 TRAF-type zinc fingers


    TRAF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF3_HUMAN, Q13114
    Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in
    the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and
    interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune
    responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3
    ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked
    ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits
    TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits
    non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14

         Genatlas biochemistry entry for TRAF3:
    tumor necrosis factor (TNF)-receptor associated factor 3,expressed in B cells,interacting with the cytoplasmic
    tail of CD40 (TNFRSF5) and other TNF receptor family members,and activating NFKB

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0004871signal transducer activity TAS7530216
    GO:0005515protein binding IPI10791955
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IEA--
         
    TRAF3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRAF3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin  Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Traf3):
     cellular  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  renal/urinary system 

    TRAF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF3: Traf3tm1Kik Traf3tm1Bal Traf3tm1.1Rbr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF3 

    miRNA
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    miRTarBase miRNAs that target TRAF3:
    hsa-mir-1 (MIRT002798)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRAF3
    8/171 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF3 (see all 171):
    hsa-miR-124* hsa-miR-361-5p hsa-miR-128 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-759 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTRAF3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3 (NM_003300)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRAF3 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    RANK Pathway0.38
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    Apoptosis and survival APRIL and BAFF signaling0.39
    2TWEAK Pathway
    TWEAK Pathway0.87
    TRAIL Pathway0.40
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    GITR Pathway0.46
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    RIG-I-like receptor signaling pathway0.52
    4Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    5Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for TRAF3 (see all 6)
        Cytoskeleton remodeling FAK signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival APRIL and BAFF signaling

    2 R&D Systems Pathways for TRAF3
        IL-17 Signaling
    Toll-Like receptor Signaling Pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF3 (see all 15)
        TWEAK Pathway
    LT-BetaR Pathway
    TRAF Pathway
    TNFR2 Pathway
    TRAIL Pathway

    2 Cell Signaling Technology (CST) Pathways for TRAF3
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for TRAF3 (see all 6)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival APRIL and BAFF signaling
    Cytoskeleton remodeling FAK signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    5/7 BioSystems Pathways for TRAF3 (see all 7)
        Apoptosis
    Apoptosis Modulation and Signaling
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    RANKL/RANK Signaling Pathway

    5/12        Reactome Pathways for TRAF3 (see all 12)
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF3-dependent IRF activation pathway
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    Toll Like Receptor 3 (TLR3) Cascade


    5/10         Kegg Pathways  (Kegg details for TRAF3) (see all 10):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    TNF signaling pathway
    Hepatitis C


    TRAF3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/135 Interacting proteins for TRAF3 (Q131141, 2, 3 ENSP000003324684) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928441, 2, 3, ENSP000002590754EBI-357631,EBI-356349 MINT-48252 MINT-47975 I2D: score=7 STRING: ENSP00000259075
    TRADDQ156282, 3, ENSP000003412684MINT-16299 I2D: score=4 STRING: ENSP00000341268
    ALPLP051862, 3, ENSP000003639654MINT-8216310 I2D: score=3 STRING: ENSP00000363965
    MAP3K14Q995582, 3MINT-48802 I2D: score=7 
    RIPK1Q135462, 3, ENSP000002598084MINT-16944 MINT-16943 I2D: score=4 STRING: ENSP00000259808
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production ISS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS7530216

    TRAF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    10/30 Novoseek inferred chemical compound relationships for TRAF3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17-(allylamino)-17-demethoxygeldanamycin 60.6 2 15057143 (1)
    threonine 56 17 1322500 (2), 8557035 (1), 11212256 (1), 11335788 (1) (see all 14)
    bcma 49.5 2 15708970 (1), 10903733 (1)
    serine 46.3 21 1322500 (2), 11134016 (2), 8557035 (1), 8637718 (1) (see all 14)
    geldanamycin 45.6 2 12843186 (1), 10558924 (1)
    oligodeoxyribonucleotides 38.1 4 7519043 (2), 8258328 (1)
    phosphatidylinositol 36.8 2 10713264 (1), 8409389 (1)
    pkcs 29.2 2 9447975 (1)
    gtp 29.2 1 9760267 (1)
    12-o-tetradecanoylphorbol 13-acetate 28.5 3 12874031 (1), 10953055 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF3 gene (4 alternative transcripts): 
    NM_001199427.1  NM_003300.3  NM_145725.2  NM_145726.2  

    Unigene Cluster for TRAF3:

    TNF receptor-associated factor 3
    Hs.510528  [show with all ESTs]
    Unigene Representative Sequence: NM_145725
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560371(uc001ymc.2 uc001ymd.2 uc001yme.2 uc010txy.2)
    ENST00000392745 ENST00000539721 ENST00000560463 ENST00000351691 ENST00000558700
    ENST00000558880 ENST00000559734 ENST00000347662
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF110908.1 AK090587.1 AK303172.1 BC075086.2 BC075087.2 BX247977.1 L38509.1 U15637.1 
    U19260.1 U21092.1 

    7 DOTS entries:

    DT.95088670  DT.100035607  DT.113194  DT.97828817  DT.95119019  DT.100035604  DT.91811986 

    24/135 AceView cDNA sequences (see all 135):

    BM917604 BI857461 AK090587 AW589978 BM773097 NM_003300 BG540100 BQ000015 
    BX247977 AA453718 AA621017 AF110908 AA654172 BX282498 U19260 AA806426 
    CB528981 AI344113 CF122082 BX442034 NM_145725 AA644442 BU507684 BM830875 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                  
    SP2:                                -                                 
    SP3:                          -     -                                 


    ECgene alternative splicing isoforms for TRAF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGACTTCC
    TRAF3 Expression
    About this image


    See TRAF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF3

    SOURCE GeneReport for Unigene cluster: Hs.510528
        SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF3 (see all 7): 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf31 , 5 TNF receptor-associated factor 31, 5 89.07(n)1
    96.3(a)1
      12 (60.94 cM)5
    220311  NM_011632.21  NP_035762.21 
     1111663705 
    chicken
    (Gallus gallus)
    Aves TRAF31 TNF receptor-associated factor 3 79.6(n)
    88.01(a)
      423471  XM_421378.3  XP_421378.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF36
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343232.1(1117283-1157266)
    zebrafish
    (Danio rerio)
    Actinopterygii traf31 TNF receptor-associated factor 3 58.79(n)
    56.44(a)
      445119  NM_001003513.1  NP_001003513.1 
    worm
    (Caenorhabditis elegans)
    Secernentea trf-16
    Y110A7A.26
    Protein Y110A7A.2
    25(a)
    20(a)
    possible ortholog
    possible ortholog
    III(13430462-13433438)
    I(5154529-5158467)


    ENSEMBL Gene Tree for TRAF3 (if available)
    TreeFam Gene Tree for TRAF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF3 gene
    TRAF12  TRAF42  TRAF52  TRAF22  TRAF62  
    4 SIMAP similar genes for TRAF3 using alignment to 5 protein entries:     TRAF3_HUMAN (see all proteins):
    TRAF5    BFAR    TRAF1    TRAF2

    TRAF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2742 SNPs in TRAF3 are shown (see all 2742)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0690814
    Herpes simplex encephalitis 3 (HSE3)4--see VAR_0690812 R W mis40--------
    rs71581661,2
    C,F,A--83418478(+) CACTGC/TAACCT 4 -- us2k14Minor allele frequency- T:0.25NA 8
    rs71581871,2
    C,F,A--84233716(+) CCTCCC/TGGGTA 4 -- us2k15Minor allele frequency- T:0.47NA 128
    rs116241331,2
    C,H--84233780(+) agagaC/Tgtggt 4 -- us2k10--------
    rs1897108791,2
    --84233784(+) ACGTGG/TTTTCA 4 -- us2k10--------
    rs777255881,2
    C,F--84233889(+) TGCCCG/AGTCCA 4 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1476190001,2
    --84234026(+) CAGTCA/GACAGG 4 -- us2k10--------
    rs1815762451,2
    --84234112(+) CCCTGA/GGCCTG 4 -- us2k10--------
    rs121475241,2
    C,F--84234202(+) GAGACC/TGCTGG 4 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1403709091,2
    --84234235(+) ACGGCA/GAAGGC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRAF3 (103243813 - 103377837 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TRAF3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672373CNV Deletion23128226
    esv1008810CNV Deletion20482838
    esv2749151CNV Deletion23290073
    nsv509552CNV Insertion20534489
    dgv1985n71CNV Loss21882294
    esv27166CNV Loss19812545
    nsv902263CNV Loss21882294
    nsv902259CNV Loss21882294
    nsv519641CNV Loss19592680
    nsv902260CNV Gain21882294


    Human Gene Mutation Database (HGMD): TRAF3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601896    OMIM disorders: --

    UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
  • Herpes simplex encephalitis 3 (HSE3) [MIM:614849]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • 20/34 diseases for TRAF3 (see all 34):    About MalaCards
    herpes simplex encephalitis 3    pulmonary neuroendocrine tumor    splenic marginal zone lymphoma    neuroendocrine tumor
    ectodermal dysplasia    headache    myeloma    influenza
    pertussis    kaposi's sarcoma    thyroid cancer    herpes simplex
    encephalitis    nasopharyngitis    acute leukemia    multiple myeloma
    b-cell lymphomas    hodgkin's lymphoma    chronic lymphocytic leukemia    hepatitis c

    1 disease from the University of Copenhagen DISEASES database for TRAF3:
    Cancer

    TRAF3 for disorders           About GeneDecksing

    10/23 Novoseek inferred disease relationships for TRAF3 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 60 26 8662842 (1), 9388227 (1), 9464265 (1), 9990007 (1) (see all 24)
    tumors 51.8 57 19074733 (3), 20386466 (3), 8451761 (2), 10632328 (2) (see all 41)
    hodgkin disease 33 5 8892903 (2), 19540595 (1), 19954665 (1), 11023520 (1)
    lymphoproliferative disorders 22.6 1 14521460 (1)
    lymphoma 12.6 6 11600226 (2), 15663562 (1), 10509816 (1)
    latent infection 12.2 1 7859281 (1)
    colorectal carcinoma 11.9 3 12147741 (1), 20386466 (1)
    autoimmunity 10.7 4 19074733 (3), 17917053 (1)
    cancer 10.7 11 19074733 (3), 11606396 (1), 10632328 (1), 8760592 (1) (see all 9)
    lung tumor 10.2 1 7545909 (1)

    Genetic Association Database (GAD): TRAF3
    Human Genome Epidemiology (HuGE) Navigator: TRAF3 (13 documents)

    Export disorders for TRAF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF3 gene, integrated from 9 sources (see all 378):
    (articles sorted by number of sources associating them with TRAF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PubMed id 7859281)1, 2, 3, 9 Mosialos G....Kieff E. (1995)
    2. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. (PubMed id 7530216)1, 2, 3 Sato T.... Reed J.C. (1995)
    3. TRAF3 controls activation of the canonical and altern ative NFkappaB by the lymphotoxin beta receptor. (PubMed id 20185819)1, 2, 9 Bista P....Lukashev M.E. (2010)
    4. LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3. (PubMed id 16009714)1, 2, 9 Wu S....Ely K.R. (2005)
    5. Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. (PubMed id 15585864)1, 2, 9 Ni C.Z....Ely K.R. (2004)
    6. TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. (PubMed id 15383523)1, 2, 9 He L....Lipsky P.E. (2004)
    7. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. (PubMed id 10199393)1, 2, 9 van Eyndhoven W.G.... Lederman S. (1998)
    8. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. (PubMed id 20097753)1, 2, 9 Mao A.P....Shu H.B. (2010)
    9. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)1, 2, 9 Li C.... Ely K.R. (2002)
    10. MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PubMed id 10791955)1, 2, 9 Ling L. and Goeddel D.V. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7187 HGNC: 12033 AceView: TRAF3 Ensembl:ENSG00000131323 euGenes: HUgn7187
    ECgene: TRAF3 Kegg: 7187 H-InvDB: TRAF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAF3 gene:
    Search GeneIP for patents involving TRAF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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