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TRAF3 Gene

protein-coding   GIFtS: 70
GCID: GC14P103243

TNF Receptor-Associated Factor 3

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNF Receptor-Associated Factor 31 2     CD40bp2
CAP12 3 5     CD40 Associated Protein 12
CRAF12 3 5     CD40 Binding Protein2
LAP12 3 5     CD40 Receptor Associated Factor 12
CAP-12 3     EC 6.3.2.-3
LMP1-Associated Protein 12 3     CD40 Receptor-Associated Factor 13
IIAE52 5     CD40-Binding Protein3
CD40BP3 5     

External Ids:    HGNC: 120331   Entrez Gene: 71872   Ensembl: ENSG000001313237   OMIM: 6018965   UniProtKB: Q131143   

Export aliases for TRAF3 gene to outside databases

Previous GC identifers: GC14P100636 GC14P097059 GC14P101233 GC14P102313 GC14P083420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAF3 Gene:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR)
superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the
activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta
receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta
ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and
several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several
alternatively spliced transcript variants encoding three distinct isoforms have been reported. (provided by
RefSeq, Dec 2010)

GeneCards Summary for TRAF3 Gene:
TRAF3 (TNF receptor-associated factor 3) is a protein-coding gene. Diseases associated with TRAF3 include herpes simplex encephalitis 3, and herpes simplex encephalitis 1. GO annotations related to this gene include protein kinase binding and signal transducer activity. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in
the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and
interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune
responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3
ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked
ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits
TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits
non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14

Gene Wiki entry for TRAF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAF3 gene promoter:
         AP-1   p53   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF3 promoter sequence
   Search Chromatin IP Primers for TRAF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.32   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.32

TRAF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P103243:  view genomic region     (about GC identifiers)

Start:
103,243,813 bp from pter      End:
103,377,837 bp from pter
Size:
134,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114 (See protein sequence)
Recommended Name: TNF receptor-associated factor 3  
Size: 568 amino acids; 64490 Da
Subunit: Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40,
TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP,
TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same
binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with
RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and
BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4,
TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr
virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14
Selected PDB 3D structures from and Proteopedia for TRAF3 (see all 8):
1FLK (3D)        1FLL (3D)        1KZZ (3D)        1L0A (3D)        1RF3 (3D)        1ZMS (3D)    
Secondary accessions: B7Z8C4 Q12990 Q13076 Q13947 Q6AZX1 Q9UNL1
Alternative splicing: 2 isoforms:  Q13114-1   Q13114-2   

Explore the universe of human proteins at neXtProt for TRAF3: NX_Q13114

Explore proteomics data for TRAF3 at MOPED

Post-translational modifications: 

  • Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by
    TNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing
    TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination
    during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both
    'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by
    OTUB1, OTUB2 and OTUD51
  • Ubiquitination2 at Lys107, Lys156, Lys369
  • Modification sites at PhosphoSitePlus

  • See TRAF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001186356.1  NP_003291.2  NP_663777.1  NP_663778.1  

    ENSEMBL proteins: 
     ENSP00000454207   ENSP00000376500   ENSP00000445998   ENSP00000453623   ENSP00000332468  
     ENSP00000453031   ENSP00000453032   ENSP00000328003  
    Reactome Protein details: Q13114

    TRAF3 Human Recombinant Protein Products:

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    Novus Biologicals TRAF3 Proteins
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    TRAF3 Antibody Products:

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    TRAF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF3
    Cloud-Clone Corp. CLIAs for TRAF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR027128 TRAF3
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR001841 Znf_RING

    Graphical View of Domain Structure for InterPro Entry Q13114

    ProtoNet protein and cluster: Q13114

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic
    processing (By similarity)
    Similarity: Belongs to the TNF receptor-associated factor family. A subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 TRAF-type zinc fingers


    TRAF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF3_HUMAN, Q13114
    Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in
    the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and
    interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune
    responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3
    ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked
    ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits
    TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits
    non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14

         Genatlas biochemistry entry for TRAF3:
    tumor necrosis factor (TNF)-receptor associated factor 3,expressed in B cells,interacting with the cytoplasmic
    tail of CD40 (TNFRSF5) and other TNF receptor family members,and activating NFKB

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0004871signal transducer activity TAS7530216
    GO:0005515protein binding IPI10791955
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IEA--
         
    TRAF3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TRAF3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin  Increased G1 DNA content 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Traf3):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  no phenotypic analysis  renal/urinary system 

    TRAF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF3: Traf3tm1Kik Traf3tm1Bal Traf3tm1.1Rbr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRAF3:
    hsa-mir-26b-5p (MIRT028936)

    Block miRNA regulation of human, mouse, rat TRAF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRAF3 (see all 171):
    hsa-miR-124* hsa-miR-361-5p hsa-miR-128 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-759 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidTRAF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRAF3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TRAF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3 (NM_003300)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRAF3_HUMAN, Q13114: Cytoplasm (Probable). Endosome (By similarity). Mitochondrion. Note=Undergoes endocytosis
    together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus3
    plasma membrane3
    endosome2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005768endosome IEA--
    GO:0005829cytosol TAS--
    GO:0009898cytoplasmic side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    TRAF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRAF3 About   (see all 28)  
    See pathways by source

    SuperPathContained pathways About
    1RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    RANK Pathway0.38
    APRIL Pathway0.92
    RANKL/RANK Signaling Pathway0.31
    Apoptosis and survival APRIL and BAFF signaling0.39
    2TWEAK Pathway
    TWEAK Pathway0.87
    TRAIL Pathway0.40
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    GITR Pathway0.46
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    4Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    5IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for TRAF3
        IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRAF3 (see all 15)
        TWEAK Pathway
    LT-BetaR Pathway
    TRAF Pathway
    TNFR2 Pathway
    TRAIL Pathway

    2 Cell Signaling Technology (CST) Pathways for TRAF3
        Apoptosis and Autophagy
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TRAF3 (see all 6)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival APRIL and BAFF signaling
    Cytoskeleton remodeling FAK signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for TRAF3 (see all 9)
        Apoptosis
    Apoptosis Modulation and Signaling
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    IL17 signaling pathway

    3 Reactome Pathways for TRAF3
        TRAF3-dependent IRF activation pathway
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
    Negative regulators of RIG-I/MDA5 signaling


    Selected Kegg Pathways  (Kegg details for TRAF3) (see all 10):
        NF-kappa B signaling pathway
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    TNF signaling pathway
    Hepatitis C


    TRAF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF3 (see all 7): 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRAF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAF3 (Q131141, 2, 3 ENSP000003324684) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TANKQ928441, 2, 3, ENSP000002590754EBI-357631,EBI-356349 MINT-48252 MINT-47975 I2D: score=7 STRING: ENSP00000259075
    TRADDQ156282, 3, ENSP000003412684MINT-16299 I2D: score=4 STRING: ENSP00000341268
    ALPLP051862, 3, ENSP000003639654MINT-8216310 I2D: score=3 STRING: ENSP00000363965
    MAP3K14Q995582, 3MINT-48802 I2D: score=7 
    RIPK2O433531, 3EBI-357631,EBI-358522 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production ISS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS7530216

    TRAF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRAF3

    Selected Novoseek inferred chemical compound relationships for TRAF3 gene (see all 30)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17-(allylamino)-17-demethoxygeldanamycin 60.6 2 15057143 (1)
    threonine 56 17 1322500 (2), 8557035 (1), 11212256 (1), 11335788 (1) (see all 14)
    bcma 49.5 2 15708970 (1), 10903733 (1)
    serine 46.3 21 1322500 (2), 11134016 (2), 8557035 (1), 8637718 (1) (see all 14)
    geldanamycin 45.6 2 12843186 (1), 10558924 (1)
    oligodeoxyribonucleotides 38.1 4 7519043 (2), 8258328 (1)
    phosphatidylinositol 36.8 2 10713264 (1), 8409389 (1)
    pkcs 29.2 2 9447975 (1)
    gtp 29.2 1 9760267 (1)
    12-o-tetradecanoylphorbol 13-acetate 28.5 3 12874031 (1), 10953055 (1)



    TRAF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAF3 gene (4 alternative transcripts): 
    NM_001199427.1  NM_003300.3  NM_145725.2  NM_145726.2  

    Unigene Cluster for TRAF3:

    TNF receptor-associated factor 3
    Hs.510528  [show with all ESTs]
    Unigene Representative Sequence: NM_145725
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560371(uc001ymc.2 uc001ymd.2 uc001yme.2 uc010txy.2)
    ENST00000392745 ENST00000539721 ENST00000560463 ENST00000351691 ENST00000558700
    ENST00000558880 ENST00000559734 ENST00000347662
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate TRAF3 (see all 171):
    hsa-miR-124* hsa-miR-361-5p hsa-miR-128 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-3921 hsa-miR-759 hsa-miR-761
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    Additional mRNA sequence: 

    AF110908.1 AK090587.1 AK303172.1 BC075086.2 BC075087.2 BX247977.1 L38509.1 U15637.1 
    U19260.1 U21092.1 

    7 DOTS entries:

    DT.95088670  DT.100035607  DT.113194  DT.97828817  DT.95119019  DT.100035604  DT.91811986 

    Selected AceView cDNA sequences (see all 135):

    BM666586 AA654172 BU507684 BX442034 BI857461 BM917604 CK429962 NM_145725 
    BQ000015 AX746522 NM_003300 BU845465 BE047751 AA928890 AW589978 CF122082 
    AK090587 BF515702 BQ053279 AI342583 BM830875 AA806426 BC075086 CB528981 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                                                  
    SP2:                                -                                 
    SP3:                          -     -                                 


    ECgene alternative splicing isoforms for TRAF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRAF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGACTTCC
    TRAF3 Expression
    About this image


    TRAF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Dental Placode Cells Dental Placode
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
    TRAF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.510528
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF3 (see all 7): 
              Antiviral Response in human mouse rat
              Type I Interferon Response in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRAF3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf31 , 5 TNF receptor-associated factor 31, 5 89.07(n)1
    96.3(a)1
      12 (60.94 cM)5
    220311  NM_011632.31  NP_035762.21 
     1111663705 
    chicken
    (Gallus gallus)
    Aves TRAF31 TNF receptor-associated factor 3 79.6(n)
    88.01(a)
      423471  XM_004936344.1  XP_004936401.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF36
    TNF receptor-associated factor 3
    78(a)
    1 ↔ 1
    GL343232.1(1117283-1157266)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia traf31 TNF receptor-associated factor 3 73.26(n)
    79.32(a)
      100498216  XM_002937990.2  XP_002938036.2 
    zebrafish
    (Danio rerio)
    Actinopterygii traf31 TNF receptor-associated factor 3 58.73(n)
    56.44(a)
      445119  NM_001003513.1  NP_001003513.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Traf-like6
    TNF-receptor-associated factor-like
    18(a)
    many ↔ many
    X(16309079-16311618)
    worm
    (Caenorhabditis elegans)
    Secernentea trf-16
    Protein TRF-1 (trf-1) mRNA, complete cds
    27(a)
    many ↔ many
    III(13430462-13433438) WBGene00006612


    ENSEMBL Gene Tree for TRAF3 (if available)
    TreeFam Gene Tree for TRAF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAF3 gene
    TRAF12  TRAF42  TRAF52  TRAF22  TRAF62  
    5 SIMAP similar genes for TRAF3 using alignment to 5 protein entries:     TRAF3_HUMAN (see all proteins):
    TRAF5    BFAR    TRAFD1    TRAF1    TRAF2

    TRAF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAF3 (see all 2742)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0690814
    Herpes simplex encephalitis 3 (HSE3)4--see VAR_0690812 R W mis40--------
    rs71581661,2
    C,F,A--83418478(+) CACTGC/TAACCT 4 -- us2k14Minor allele frequency- T:0.25NA 8
    rs71581871,2
    C,F,A--84233716(+) CCTCCC/TGGGTA 4 -- us2k15Minor allele frequency- T:0.47NA 128
    rs116241331,2
    C,H--84233780(+) agagaC/Tgtggt 4 -- us2k10--------
    rs1897108791,2
    --84233784(+) ACGTGG/TTTTCA 4 -- us2k10--------
    rs777255881,2
    C,F--84233889(+) TGCCCG/AGTCCA 4 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1476190001,2
    --84234026(+) CAGTCA/GACAGG 4 -- us2k10--------
    rs1815762451,2
    --84234112(+) CCCTGA/GGCCTG 4 -- us2k10--------
    rs121475241,2
    C,F--84234202(+) GAGACC/TGCTGG 4 -- us2k15Minor allele frequency- T:0.29NA EA 246
    rs1403709091,2
    --84234235(+) ACGGCA/GAAGGC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRAF3 (103243813 - 103377837 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRAF3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672373CNV Deletion23128226
    esv1008810CNV Deletion20482838
    esv2749151CNV Deletion23290073
    nsv509552CNV Insertion20534489
    dgv1985n71CNV Loss21882294
    esv27166CNV Loss19812545
    nsv902263CNV Loss21882294
    nsv902259CNV Loss21882294
    nsv519641CNV Loss19592680
    nsv902260CNV Gain21882294

    Human Gene Mutation Database (HGMD): TRAF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF3
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601896   
    OMIM disorders: 614849  
    UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
  • Herpes simplex encephalitis 3 (HSE3) [MIM:614849]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry

  • Selected diseases for TRAF3 (see all 43):    
    About MalaCards
    herpes simplex encephalitis 3    herpes simplex encephalitis 1    herpes simplex encephalitis    pulmonary neuroendocrine tumor
    herpes simplex    splenic marginal zone lymphoma    ectodermal dysplasia    encephalitis
    neuroendocrine tumor    headache    influenza    myeloma
    pertussis    thyroid cancer    acute leukemia    kaposi's sarcoma
    multiple myeloma    nasopharyngitis    b-cell lymphomas    hepatitis c

    1 disease from the University of Copenhagen DISEASES database for TRAF3:
    Cancer

    TRAF3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TRAF3 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 60 26 8662842 (1), 9388227 (1), 9464265 (1), 9990007 (1) (see all 24)
    tumors 51.8 57 19074733 (3), 20386466 (3), 8451761 (2), 10632328 (2) (see all 41)
    hodgkin disease 33 5 8892903 (2), 19540595 (1), 19954665 (1), 11023520 (1)
    lymphoproliferative disorders 22.6 1 14521460 (1)
    lymphoma 12.6 6 11600226 (2), 15663562 (1), 10509816 (1)
    latent infection 12.2 1 7859281 (1)
    colorectal carcinoma 11.9 3 12147741 (1), 20386466 (1)
    autoimmunity 10.7 4 19074733 (3), 17917053 (1)
    cancer 10.7 11 19074733 (3), 11606396 (1), 10632328 (1), 8760592 (1) (see all 9)
    lung tumor 10.2 1 7545909 (1)

    Genetic Association Database (GAD): TRAF3
    Human Genome Epidemiology (HuGE) Navigator: TRAF3 (13 documents)

    Export disorders for TRAF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAF3 gene, integrated from 10 sources (see all 381):
    (articles sorted by number of sources associating them with TRAF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PubMed id 7859281)1, 2, 3, 9 Mosialos G....Kieff E. (Cell 1995)
    2. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. (PubMed id 7530216)1, 2, 3 Sato T.... Reed J.C. (FEBS Lett. 1995)
    3. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. (PubMed id 20185819)1, 2, 9 Bista P.... Lukashev M.E. (J. Biol. Chem. 2010)
    4. LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3. (PubMed id 16009714)1, 2, 9 Wu S.... Ely K.R. (J. Biol. Chem. 2005)
    5. Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. (PubMed id 15585864)1, 2, 9 Ni C.Z.... Ely K.R. (J. Immunol. 2004)
    6. TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. (PubMed id 15383523)1, 2, 9 He L.... Lipsky P.E. (J. Biol. Chem. 2004)
    7. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. (PubMed id 10199393)1, 2, 9 van Eyndhoven W.G.... Lederman S. (Mol. Immunol. 1998)
    8. Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. (PubMed id 20097753)1, 2, 9 Mao A.P.... Shu H.B. (J. Biol. Chem. 2010)
    9. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)1, 2, 9 Li C.... Ely K.R. (Structure 2002)
    10. MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PubMed id 10791955)1, 2, 9 Ling L. and Goeddel D.V. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7187 HGNC: 12033 AceView: TRAF3 Ensembl:ENSG00000131323 euGenes: HUgn7187
    ECgene: TRAF3 Kegg: 7187 H-InvDB: TRAF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRAF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRAF3 gene:
    Search GeneIP for patents involving TRAF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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