TRAF3 Gene
protein-coding GIFtS: 68
GCID: GC14P103243
|
|
TNF receptor-associated factor 3
| |
Aliases
for TRAF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNF Receptor-Associated Factor 31 2 | | CD40 Associated Protein 12 | | CAP-11 2 3 | | CD40 Binding Protein2 | | CRAF11 2 3 | | CD40 Receptor Associated Factor 12 | | LAP11 2 3 | | CD40BP3 | | CD40bp1 2 | | EC 6.3.2.-3 | | CAP12 3 | | CD40 Receptor-Associated Factor 13 | | LMP1-Associated Protein 12 3 | | CD40-Binding Protein3 | | IIAE52 | | |
Export aliases for TRAF3 gene to outside databasesPrevious GC identifers: GC14P100636 GC14P097059 GC14P101233 GC14P102313 GC14P083420 |
Summaries
for TRAF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRAF3:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This proteinparticipates in the signal transduction of CD40, a TNFR family member important for the activation of the immuneresponse. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signalingcomplex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encodedlatent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, whichmay be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding threedistinct isoforms have been reported. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Playsa role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligasecomplexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of targetproteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation ofNF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation ofNF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14
Gene Wiki entry for TRAF3
|
Genomic Views
for TRAF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRAF3 gene promoter:
AP-1 p53 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRAF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.32 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32.32TRAF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P103243: view genomic region
(about GC identifiers)
Start:
|
103,243,813 bp from pter |
End:
|
103,377,837 bp from pter |
Size:
|
134,025 bases |
Orientation:
|
plus strand |
|
Proteins
for TRAF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114 (See
protein sequence)Recommended Name: TNF receptor-associated factor 3 Size: 568 amino acids; 64490 Da
Subunit: Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40,TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP,TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same bindingsite. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216,MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Uponexposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG,MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr virus protein LMP1.Interacts (via RING-type zinc finger domain) with SRC
Subcellular location: Cytoplasm (Probable). Endosome (By similarity). Mitochondrion. Note=Undergoes endocytosistogether with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus
6/8 PDB 3D structures from  and Proteopedia  for TRAF3 (see all 8):1FLK (3D)
1FLL (3D)
1KZZ (3D)
1L0A (3D)
1RF3 (3D)
1ZMS (3D)
Secondary accessions: B7Z8C4 Q12990 Q13076 Q13947 Q6AZX1 Q9UNL1Alternative splicing: 2 isoforms: Q13114-1 Q13114-2 Explore the universe of human proteins at neXtProt for TRAF3: NX_Q13114
Post-translational modifications:
Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling byTNFSF13B, TLR4 or through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during earlystages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD51
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13114
TRAF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001186356.1 NP_003291.2 NP_663777.1 NP_663778.1
ENSEMBL proteins: ENSP00000454207 ENSP00000376500 ENSP00000445998 ENSP00000453623 ENSP00000332468 ENSP00000453031 ENSP00000453032 ENSP00000328003 Reactome Protein details: Q13114
Human Recombinant Protein Products for TRAF3:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TRAF3 for ontologies About GeneDecksing
TRAF3 Antibody Products:
Assay Products for TRAF3: |
Protein
Domains /
Families
for TRAF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRAF3 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q13114ProtoNet protein and cluster: Q13114 3 Blocks protein families: IPB001293 Zn-finger IPB001841 Zn-finger IPB002083 Meprin/TRAF-like MATH
UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114Domain: The MATH/TRAF domain binds to receptor cytoplasmic domainsDomain: The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolyticprocessing (By similarity)Similarity: Belongs to the TNF receptor-associated factor family. A subfamilySimilarity: Contains 1 MATH domainSimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 2 TRAF-type zinc fingers |
Function
for TRAF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TRAF3_HUMAN, Q13114Function: Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon.Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Playsa role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligasecomplexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of targetproteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation ofNF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation ofNF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14 Genatlas biochemistry entry for TRAF3:tumor necrosis factor (TNF)-receptor associated factor 3,expressed in B cells,interacting with the cytoplasmic tail ofCD40 (TNFRSF5) and other TNF receptor family members,and activating NFKB
Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TRAF3 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for TRAF3:
9 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Traf3):
TRAF3 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for TRAF3: Traf3tm1Kik Traf3tm1Bal Traf3tm1.1Rbr
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3 (NM_003300) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAF3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3 |
|
Pathways & Interactions
for TRAF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | BAFF in B-Cell Signaling | | | 2 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 3 | TWEAK Pathway | | | 4 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | | | 5 | Apoptosis and survival_Lymphotoxin-beta receptor signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for TRAF3 (see all 6)
1  R&D Systems Pathway for TRAF3
5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF3 (see all 15)
2 
Cell Signaling Technology (CST) Pathways for TRAF3
5/6  GeneGo (Thomson Reuters) Pathways for TRAF3 (see all 6)
5/7  BioSystems Pathways for TRAF3 (see all 7)
5/15 
Reactome Pathways for TRAF3 (see all 15)
5 
Kegg Pathways (Kegg details for TRAF3):
TRAF3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/135 Interacting proteins for TRAF3 (Q131141, 2, 3 ENSP000003324684) via UniProtKB, MINT, STRING, and/or I2D (see all 135)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TANK | Q928441, 2, 3, ENSP000002590754 | EBI-357631,EBI-356349 MINT-48252 MINT-47975 I2D:
score=7 STRING: ENSP00000259075 | | TRADD | Q156282, 3, ENSP000003412684 | MINT-16299 I2D:
score=4 STRING: ENSP00000341268 | | ALPL | P051862, 3, ENSP000003639654 | MINT-8216310 I2D:
score=3 STRING: ENSP00000363965 | | MAP3K14 | Q995582, 3 | MINT-48802 I2D:
score=7 | | RIPK1 | Q135462, 3, ENSP000002598084 | MINT-16944 MINT-16943 I2D:
score=4 STRING: ENSP00000259808 |
About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
TRAF3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRAF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRAF3 for compounds About GeneDecksing
 Browse Tocris compounds for TRAF3
10/30 Novoseek chemical compound relationships for TRAF3 gene (see all 30) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 17-(allylamino)-17-demethoxygeldanamycin |
60.6 |
2 |
15057143 (1) |
| threonine |
56 |
17 |
1322500 (2), 8557035 (1), 11212256 (1), 11335788 (1) (see all 14) |
| bcma |
49.5 |
2 |
15708970 (1), 10903733 (1) |
| serine |
46.3 |
21 |
1322500 (2), 11134016 (2), 8557035 (1), 8637718 (1) (see all 14) |
| geldanamycin |
45.6 |
2 |
12843186 (1), 10558924 (1) |
| oligodeoxyribonucleotides |
38.1 |
4 |
7519043 (2), 8258328 (1) |
| phosphatidylinositol |
36.8 |
2 |
10713264 (1), 8409389 (1) |
| pkcs |
29.2 |
2 |
9447975 (1) |
| gtp |
29.2 |
1 |
9760267 (1) |
| 12-o-tetradecanoylphorbol 13-acetate |
28.5 |
3 |
12874031 (1), 10953055 (1) |
Search CenterWatch for drugs/clinical trials and news about TRAF3
|
Transcripts
for TRAF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRAF3 gene (4 alternative transcripts): NM_001199427.1 NM_003300.3 NM_145725.2 NM_145726.2 Unigene Cluster for TRAF3: TNF receptor-associated factor 3 Hs.510528 [show with all ESTs]Unigene Representative Sequence: NM_1457259 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560371(uc001ymc.2 uc001ymd.2 uc001yme.2 uc010txy.2)
ENST00000392745 ENST00000539721 ENST00000560463 ENST00000351691 ENST00000558700
ENST00000558880 ENST00000559734 ENST00000347662
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TRAF3 (NM_003300) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF3 |
Additional cDNA sequence: AF110908.1 AK090587.1 AK303172.1 BC075086.2 BC075087.2 BX247977.1 L38509.1 U15637.1 U19260.1 U21092.1 7 DOTS entries: DT.95088670 DT.100035607 DT.113194 DT.97828817 DT.95119019 DT.100035604 DT.91811986 24/135 AceView cDNA sequences (see all 135): BF515702 BX442034 BM830875 CK429962 AA928890 AI342583 BM773097 BM464801 AI721219 NM_003300 NM_145726 AX746522 AA453718 BM701731 BM666586 BU629341 CB160895 AW589978 BX282498 BU845465 CA308360 AA654172 BC075087 CF122082
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRAF3
|
Expression
for TRAF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRAF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGACTTCC
About this image
See TRAF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF3
SOURCE GeneReport for Unigene cluster: Hs.510528
SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF3 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF3 |
Orthologs
for TRAF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRAF3 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for TRAF3 (if available)
TreeFam Gene Tree for TRAF3 (if available) |
Paralogs
for TRAF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRAF3 gene
- TRAF12 TRAF42 TRAF52 TRAF22 TRAF62
5 SIMAP similar genes for TRAF3 using alignment to 5 protein entries: TRAF3_HUMAN (see all proteins):TRAF5 BFAR TRAF1 TRAF2 LONRF1
TRAF3 for paralogs About GeneDecksing
|
Genomic Variants
for TRAF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRAF3 (103243813 - 103377837 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TRAF3
5 CNVs: 71968 87366 0180 49287 76737
Human Gene Mutation Database (HGMD): TRAF3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF3 |
|
Disorders
/ Diseases
for TRAF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRAF3 for disorders About GeneDecksing
OMIM gene information: 601896
OMIM disorders: --
UniProtKB/Swiss-Prot: TRAF3_HUMAN, Q13114
Defects in TRAF3 are the cause of susceptibility to herpes simplex encephalitis 3 (HSE3) [MIM:614849]. A rarecomplication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infectedindividuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is overseveral days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome
20/38  diseases for TRAF3 (see all 38): About MalaCardssplenic marginal zone lymphoma b-cell lymphomas ectodermal dysplasia pulmonary neuroendocrine tumor
neuroendocrine tumor megakaryoblastic leukemia chronic lymphocytic leukemia breast-ovarian cancer
herpes simplex lymphocytic leukemia kaposi's sarcoma squamous cell carcinoma
hodgkin's lymphoma multiple myeloma ovarian carcinoma carcinoma
myeloma hepatitis c ovarian cancer lung carcinoma
1 disease from the University of Copenhagen DISEASES database for TRAF3:Cancer 10/23 Novoseek disease relationships for TRAF3 gene (see all 23) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
60 |
26 |
8662842 (1), 9388227 (1), 9464265 (1), 9990007 (1) (see all 24) |
| tumors |
51.8 |
57 |
19074733 (3), 20386466 (3), 8451761 (2), 10632328 (2) (see all 41) |
| hodgkin disease |
33 |
5 |
8892903 (2), 19540595 (1), 19954665 (1), 11023520 (1) |
| lymphoproliferative disorders |
22.6 |
1 |
14521460 (1) |
| lymphoma |
12.6 |
6 |
11600226 (2), 15663562 (1), 10509816 (1) |
| latent infection |
12.2 |
1 |
7859281 (1) |
| colorectal carcinoma |
11.9 |
3 |
12147741 (1), 20386466 (1) |
| autoimmunity |
10.7 |
4 |
19074733 (3), 17917053 (1) |
| cancer |
10.7 |
11 |
19074733 (3), 11606396 (1), 10632328 (1), 8760592 (1) (see all 9) |
| lung tumor |
10.2 |
1 |
7545909 (1) |
Human Genome Epidemiology (HuGE) Navigator: TRAF3 (13 documents)
Export disorders for TRAF3 gene to outside databases
|
Publications
for TRAF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRAF3 gene, integrated from 9 sources (see all 364):
(articles sorted by number of sources associating them with TRAF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PubMed id 7859281)1, 2, 3, 9 Mosialos G....Kieff E. (1995)
- A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. (PubMed id 7530216)1, 2, 3 Sato T.... Reed J.C. (1995)
- TRAF3 controls activation of the canonical and altern ative NFkappaB by the lymphotoxin beta receptor. (PubMed id 20185819)1, 2, 9 Bista P....Lukashev M.E. (2010)
- LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3. (PubMed id 16009714)1, 2, 9 Wu S....Ely K.R. (2005)
- Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. (PubMed id 15585864)1, 2, 9 Ni C.Z....Ely K.R. (2004)
- TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation. (PubMed id 15383523)1, 2, 9 He L....Lipsky P.E. (2004)
- A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. (PubMed id 10199393)1, 2, 9 van Eyndhoven W.G.... Lederman S. (1998)
- Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. (PubMed id 20097753)1, 2, 9 Mao A.P....Shu H.B. (2010)
- Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)1, 2, 9 Li C.... Ely K.R. (2002)
- MIP-T3, a novel protein linking tumor necrosis factor receptor- associated factor 3 to the microtubule network. (PubMed id 10791955)1, 2, 9 Ling L. and Goeddel D.V. (2000)
|
External Searches for TRAF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TRAF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing TRAF3 gene
(According to HUGE)
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| -- |
Specialized Databases showing TRAF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for TRAF3 gene:
Search GeneIP for patents involving TRAF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRAF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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|
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