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Aliases for TRAF3 Gene

Aliases for TRAF3 Gene

  • TNF Receptor Associated Factor 3 2 3 5
  • LMP1-Associated Protein 1 3 4
  • CD40bp 3 4
  • CAP-1 3 4
  • CRAF1 3 4
  • LAP1 3 4
  • CAP1 3 4
  • CD40 Receptor Associated Factor 1 3
  • CD40 Receptor-Associated Factor 1 4
  • CD40 Associated Protein 1 3
  • CD40 Binding Protein 3
  • CD40-Binding Protein 4
  • EC 6.3.2.- 4
  • IIAE5 3

External Ids for TRAF3 Gene

Previous GeneCards Identifiers for TRAF3 Gene

  • GC14P100636
  • GC14P097059
  • GC14P101233
  • GC14P102313
  • GC14P103243
  • GC14P083420

Summaries for TRAF3 Gene

Entrez Gene Summary for TRAF3 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010]

GeneCards Summary for TRAF3 Gene

TRAF3 (TNF Receptor Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include herpes simplex encephalitis 3 and herpes simplex encephalitis. Among its related pathways are Platelet activation, signaling and aggregation and Immune System. GO annotations related to this gene include protein kinase binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF3 Gene

  • Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote Lys-63-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Gene Wiki entry for TRAF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF3 Gene

Genomics for TRAF3 Gene

Regulatory Elements for TRAF3 Gene

Promoters for TRAF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAF3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRAF3 gene promoter:

Genomic Location for TRAF3 Gene

Chromosome:
14
Start:
102,777,475 bp from pter
End:
102,911,500 bp from pter
Size:
134,026 bases
Orientation:
Plus strand

Genomic View for TRAF3 Gene

Genes around TRAF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF3 Gene

Proteins for TRAF3 Gene

  • Protein details for TRAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13114-TRAF3_HUMAN
    Recommended name:
    TNF receptor-associated factor 3
    Protein Accession:
    Q13114
    Secondary Accessions:
    • B7Z8C4
    • Q12990
    • Q13076
    • Q13947
    • Q6AZX1
    • Q9UNL1

    Protein attributes for TRAF3 Gene

    Size:
    568 amino acids
    Molecular mass:
    64490 Da
    Quaternary structure:
    • Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14, TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, MAVS, OPTN and TBK1. Identified in a complex with TRAF2, MAP3K14 and BIRC3. Interacts with BIRC2 and BIRC3. Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88, TICAM1, BIRC2, BIRC3 and UBE2N (By similarity). Interacts with Epstein-Barr virus protein LMP1. Interacts (via RING-type zinc finger domain) with SRC. Interacts with CARD14. Interacts (via MATH domain) with PTPN22; the interaction promotes TRAF3 polyubiquitination (PubMed:23871208).

    Three dimensional structures from OCA and Proteopedia for TRAF3 Gene

    Alternative splice isoforms for TRAF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF3 Gene

Proteomics data for TRAF3 Gene at MOPED

Post-translational modifications for TRAF3 Gene

  • Undergoes Lys-48-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. Lys-48-linked polyubiquitinated form is deubiquitinated by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Undergoes Lys-63-linked ubiquitination during early stages of virus infection, and Lys-48-linked ubiquitination during later stages. Undergoes both Lys-48-linked and Lys-63-linked ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated by OTUB1, OTUB2 and OTUD5.
  • Ubiquitination at Lys 107, Lys 156, and Lys 369
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF3 (TRAF3)

No data available for DME Specific Peptides for TRAF3 Gene

Domains & Families for TRAF3 Gene

Gene Families for TRAF3 Gene

Suggested Antigen Peptide Sequences for TRAF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13114

UniProtKB/Swiss-Prot:

TRAF3_HUMAN :
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
  • Contains 1 RING-type zinc finger.
Domain:
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.
  • Contains 1 MATH domain.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 2 TRAF-type zinc fingers.
genes like me logo Genes that share domains with TRAF3: view

Function for TRAF3 Gene

Molecular function for TRAF3 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor associated factor 3,expressed in B cells,interacting with the cytoplasmic tail of CD40 (TNFRSF5) and other TNF receptor family members,and activating NFKB
UniProtKB/Swiss-Prot Function:
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote Lys-63-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Enzyme Numbers (IUBMB) for TRAF3 Gene

Gene Ontology (GO) - Molecular Function for TRAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0031996 thioesterase binding IPI 11279055
genes like me logo Genes that share ontologies with TRAF3: view
genes like me logo Genes that share phenotypes with TRAF3: view

Human Phenotype Ontology for TRAF3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRAF3 Gene

MGI Knock Outs for TRAF3:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for TRAF3 Gene

Localization for TRAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF3 Gene

Cytoplasm. Endosome. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF3 Gene COMPARTMENTS Subcellular localization image for TRAF3 gene
Compartment Confidence
cytosol 5
mitochondrion 5
endosome 4
nucleus 4
plasma membrane 4
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for TRAF3 Gene

Pathways & Interactions for TRAF3 Gene

genes like me logo Genes that share pathways with TRAF3: view

SIGNOR curated interactions for TRAF3 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for TRAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0007165 signal transduction IEA,TAS 7530216
GO:0008063 Toll signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032480 negative regulation of type I interferon production TAS --
genes like me logo Genes that share ontologies with TRAF3: view

Drugs & Compounds for TRAF3 Gene

(16) Drugs for TRAF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for TRAF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF3: view

Transcripts for TRAF3 Gene

Unigene Clusters for TRAF3 Gene

TNF receptor-associated factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3: - -

Relevant External Links for TRAF3 Gene

GeneLoc Exon Structure for
TRAF3
ECgene alternative splicing isoforms for
TRAF3

Expression for TRAF3 Gene

mRNA expression in normal human tissues for TRAF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF3 Gene

This gene is overexpressed in Retina (16.1), Heart (15.2), Fetal Brain (11.5), Adipocyte (9.1), Placenta (7.0), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF3 Gene



SOURCE GeneReport for Unigene cluster for TRAF3 Gene Hs.510528

genes like me logo Genes that share expression patterns with TRAF3: view

Protein tissue co-expression partners for TRAF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAF3 Gene

Orthologs for TRAF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAF3 35
  • 88.03 (n)
  • 94.72 (a)
TRAF3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF3 35
  • 90.79 (n)
  • 96.13 (a)
TRAF3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf3 35
  • 89.07 (n)
  • 96.3 (a)
Traf3 16
Traf3 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRAF3 35
  • 99.65 (n)
  • 99.82 (a)
TRAF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf3 35
  • 88.71 (n)
  • 95.24 (a)
oppossum
(Monodelphis domestica)
Mammalia TRAF3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF3 35
  • 79.6 (n)
  • 88.01 (a)
TRAF3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia traf3 35
  • 73.26 (n)
  • 79.32 (a)
zebrafish
(Danio rerio)
Actinopterygii traf3 35
  • 58.73 (n)
  • 56.44 (a)
traf3 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1068 35
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7175 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for TRAF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF3 Gene

ENSEMBL:
Gene Tree for TRAF3 (if available)
TreeFam:
Gene Tree for TRAF3 (if available)

Paralogs for TRAF3 Gene

Paralogs for TRAF3 Gene

(5) SIMAP similar genes for TRAF3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRAF3: view

Variants for TRAF3 Gene

Sequence variations from dbSNP and Humsavar for TRAF3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1131877 - 102,875,712(-) CCAGC(A/G)TTAAC nc-transcript-variant, reference, missense
VAR_069081 Herpes simplex encephalitis 3 (HSE3)
rs1046299 -- 102,910,988(+) AGGGC(A/G)GTGTC utr-variant-3-prime
rs1051742 -- 102,905,430(-) TTATA(A/G)CCAAA reference, synonymous-codon
rs1051743 -- 102,903,404(-) CCCGC(A/G)CTCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRAF3 Gene

Variant ID Type Subtype PubMed ID
nsv902258 CNV Gain 21882294
esv27166 CNV Loss 19812545
nsv483032 CNV Gain 15286789
esv1008810 CNV Deletion 20482838
esv2749151 CNV Deletion 23290073
nsv902259 CNV Loss 21882294
nsv902260 CNV Gain 21882294
esv2672373 CNV Deletion 23128226
nsv519641 CNV Loss 19592680
nsv509552 CNV Insertion 20534489
dgv1985n71 CNV Loss 21882294
nsv902263 CNV Loss 21882294
nsv9167 CNV Gain 18304495

Variation tolerance for TRAF3 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF3 Gene

HapMap Linkage Disequilibrium report
TRAF3
Human Gene Mutation Database (HGMD)
TRAF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF3 Gene

Disorders for TRAF3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TRAF3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex encephalitis 3
  • herpes simplex encephalitis, susceptibility to, 3
herpes simplex encephalitis
  • herpes simplex meningo-encephalitis
encephalitis
herpes simplex
  • herpesvirus hominis disease
cd40 deficiency
  • type 3 hyper-igm immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search TRAF3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRAF3_HUMAN
  • Herpes simplex encephalitis 3 (HSE3) [MIM:614849]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:20832341}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TRAF3

Genetic Association Database (GAD)
TRAF3
Human Genome Epidemiology (HuGE) Navigator
TRAF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF3
genes like me logo Genes that share disorders with TRAF3: view

No data available for Genatlas for TRAF3 Gene

Publications for TRAF3 Gene

  1. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PMID: 7859281) Mosialos G. … Kieff E. (Cell 1995) 2 3 4 23 67
  2. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (PMID: 19996094) Li S. … Shu H.B. (J. Biol. Chem. 2010) 3 23
  3. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. (PMID: 20185819) Bista P. … Lukashev M.E. (J. Biol. Chem. 2010) 3 23
  4. Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor. (PMID: 20348096) Sanjo H. … Ware C.F. (J. Biol. Chem. 2010) 3 23
  5. [The action mechanisms of unclassical NF-kappaB activity and TRAF3 expression in Hodgkin's lymphoma cells]. (PMID: 19954665) Guo F. … Chen Z.X. (Zhonghua Xue Ye Xue Za Zhi 2009) 3 23

Products for TRAF3 Gene

Sources for TRAF3 Gene

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