Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRAF2 Gene

protein-coding   GIFtS: 67
GCID: GC09P139776

TNF Receptor-Associated Factor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TNF Receptor-Associated Factor 21 2     MGC:450122
Tumor Necrosis Factor Type 2 Receptor-Associated Protein 32 3     TRAP2
TRAP32 3     Tumor Necrosis Factor Type 2 Receptor Associated Protein 32
E3 Ubiquitin-Protein Ligase TRAF22 3     EC 6.3.2.-3

External Ids:    HGNC: 120321   Entrez Gene: 71862   Ensembl: ENSG000001271917   OMIM: 6018955   UniProtKB: Q129333   

Export aliases for TRAF2 gene to outside databases

Previous GC identifers: GC09P131016 GC09P131470 GC09P133221 GC09P135138 GC09P137056 GC09P138900 GC09P109252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRAF2 Gene:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This
protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein
and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated
apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the
degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only one transcript has been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRAF2 Gene:
TRAF2 (TNF receptor-associated factor 2) is a protein-coding gene. Diseases associated with TRAF2 include factor 2 deficiency, and splenomegaly. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival
and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase
activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an
essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of
target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein
levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2
RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with
BIRC2 or BIRC3, promotes ubiquitination of IKBKE

Gene Wiki entry for TRAF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAF2 gene promoter:
         AP-1   p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF2 promoter sequence
   Search Chromatin IP Primers for TRAF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

TRAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139776:  view genomic region     (about GC identifiers)

Start:
139,776,364 bp from pter      End:
139,821,067 bp from pter
Size:
44,704 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933 (See protein sequence)
Recommended Name: TNF receptor-associated factor 2  
Size: 501 amino acids; 55859 Da
Subunit: Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type
and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4,
TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR,
TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and
IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1,
TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2,
NFATC2IP, PEG3 and HIVEP3. Interacts with ERN1; the interaction requires DAB2IP. Interacts with BIRC2 and BIRC3
N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2
homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or
BIRC3 is essential for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts
with CYLD, USP48, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via
'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3
is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2
phosphorylation. Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain); the interaction occurs in
a TNF-alpha-dependent manner. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain).
Interacts with CARD14. Interacts with PTPN2; probably involved in tumor necrosis factor-mediated signaling
Selected PDB 3D structures from and Proteopedia for TRAF2 (see all 14):
1CA4 (3D)        1CA9 (3D)        1CZY (3D)        1CZZ (3D)        1D00 (3D)        1D01 (3D)    
Secondary accessions: A8K107 B4DPJ7 Q7Z337 Q96NT2
Alternative splicing: 4 isoforms:  Q12933-1   Q12933-2   Q12933-3   Q12933-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF2: NX_Q12933

Explore proteomics data for TRAF2 at MOPED

Post-translational modifications: 

  • Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in
    response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked
    polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for
    interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B1
  • Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked
    ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked
    polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys
    residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation.
    Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2,
    leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves
    'Lys-63'-linked polyubiquitin chains1
  • Ubiquitination2 at Lys21, Lys27, Lys31, Lys140, Lys176, Lys255, Lys313, Lys320, Lys331, Lys481
  • Modification sites at PhosphoSitePlus

  • See TRAF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066961.2  
    ENSEMBL proteins: 
     ENSP00000405860   ENSP00000406524   ENSP00000247668   ENSP00000397653   ENSP00000446414  
     ENSP00000352685  
    Reactome Protein details: Q12933

    TRAF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRAF2
    OriGene Protein Over-expression Lysate for TRAF2
    OriGene MassSpec for TRAF2
    OriGene Custom Protein Services for TRAF2
    GenScript Custom Purified and Recombinant Proteins Services for TRAF2
    Novus Biologicals TRAF2 Proteins
    Novus Biologicals TRAF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TRAF2
    Cloud-Clone Corp. Proteins for TRAF2

    TRAF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAF2
    R&D Systems Antibodies for TRAF2 (TRAF-2)
    Cell Signaling Technology (CST) Antibodies for TRAF2 
    OriGene Antibodies for TRAF2
    OriGene Custom Antibody Services for TRAF2
    Novus Biologicals TRAF2 Antibodies
    Abcam antibodies for TRAF2
    Cloud-Clone Corp. Antibodies for TRAF2
    ThermoFisher Antibody for TRAF2
    LSBio Antibodies in human, mouse, rat for TRAF2

    TRAF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRAF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRAF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF2
    Cloud-Clone Corp. CLIAs for TRAF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR001841 Znf_RING
     IPR027133 TRAF2

    Graphical View of Domain Structure for InterPro Entry Q12933

    ProtoNet protein and cluster: Q12933

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
    Domain: The coiled coil domain mediates homo- and hetero-oligomerization
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not
    essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling
    Similarity: Belongs to the TNF receptor-associated factor family. A subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 TRAF-type zinc fingers


    TRAF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF2_HUMAN, Q12933
    Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival
    and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase
    activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an
    essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of
    target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein
    levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2
    RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with
    BIRC2 or BIRC3, promotes ubiquitination of IKBKE
    Enzyme regulation: Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3
    ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate

         Genatlas biochemistry entry for TRAF2:
    tumor necrosis factor (TNF)- receptor-associated factor,variably expressed in heart,liver,placenta,brain,skeletal
    muscle,kidney,pancreas,intestinal epithelial cells,potentiial mediator of CD40 (TNFRSF5) and TNFR2
    signaling,involved in both IL1B and TNF/alpha signaling cascades,implicated in TNFR-mediated NF-kappa B
    activation in association with MAPK8

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15258597
    GO:0004871signal transducer activity NAS8702708
    GO:0005102receptor binding ----
    GO:0005164tumor necrosis factor receptor binding IPI11279055
    GO:0005174CD40 receptor binding ISS--
         
    TRAF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAF2:
     Downregulation of NF-kappaB pa  Increased cell death HMECs cel 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Traf2):
     adipose tissue  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle 

    TRAF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF2: Traf2tm1.1Rbr Traf2tm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TRAF2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRAF2
    SwitchGear 3'UTR luciferase reporter plasmidTRAF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAF2
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRAF2

    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF2 (see all 7)
    OriGene ORF clones in mouse, rat for TRAF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF2 (NM_021138)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRAF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRAF2_HUMAN, Q12933: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005938cell cortex IEA--
    GO:0009898cytoplasmic side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    TRAF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TRAF2 About   (see all 50)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    TRAIL Pathway0.40
    2RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5LT-BetaR Pathway
    Apoptosis and survival Lymphotoxin beta receptor signaling0.46
    LT-BetaR Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TRAF2
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRAF2 (see all 36)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for TRAF2
        Apoptosis and Autophagy
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TRAF2 (see all 9)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for TRAF2 (see all 14)
        MAPK signaling pathway
    Apoptosis
    p38 MAPK Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    Integrated Pancreatic Cancer Pathway

    Selected Reactome Pathways for TRAF2 (see all 6)
        TNF signaling
    Caspase-8 activation
    TRAF6 mediated IRF7 activation
    TRAF6 mediated NF-kB activation
    Regulation by c-FLIP


    Selected Kegg Pathways  (Kegg details for TRAF2) (see all 15):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Protein processing in endoplasmic reticulum
    Apoptosis
    Osteoclast differentiation

    UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
    Pathway: Protein modification; protein ubiquitination


    TRAF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF2 (see all 11): 

              NFKB Signaling Targets in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat
              p53 Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAF2 (Q129331, 2, 3 ENSP000002476684) via UniProtKB, MINT, STRING, and/or I2D (see all 481)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074372, 3, ENSP000004100714MINT-49553 I2D: score=3 STRING: ENSP00000410071
    ENSG00000235067P074372, 3, ENSP000004013174MINT-49553 I2D: score=3 STRING: ENSP00000401317
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002726positive regulation of T cell cytokine production IMP15125833
    GO:0006461protein complex assembly TAS8702708
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007165signal transduction TAS8702708

    TRAF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAF2

    Selected Novoseek inferred chemical compound relationships for TRAF2 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap1 82.1 16 16282325 (6), 18827186 (3), 20053756 (2), 15265700 (1)
    tab-1 68.4 4 19966933 (1), 17439942 (1), 17633026 (1), 17673602 (1)
    sb 203580 39.3 1 10823821 (1)
    leptomycin b 28.2 1 11801607 (1)
    bortezomib 27.9 1 16024631 (1)
    zinc 24.4 10 19810754 (2), 9647239 (1), 14713952 (1), 15545599 (1) (see all 8)
    threonine 17.7 1 10477597 (1)
    n acetylcysteine 13.8 1 10788610 (1)
    cycloheximide 9.8 1 9813034 (1)
    phosphatidylinositol 8.81 2 15115707 (2)



    TRAF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRAF2 gene: 
    NM_021138.3  

    Unigene Cluster for TRAF2:

    TNF receptor-associated factor 2
    Hs.522506  [show with all ESTs]
    Unigene Representative Sequence: BC064662
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419057 ENST00000429509 ENST00000247668(uc010nbu.3 uc004cjv.3 uc011mek.2 uc010nbw.3)
    ENST00000414589 ENST00000474950 ENST00000482854 ENST00000469701 ENST00000466107
    ENST00000536468 ENST00000359662(uc010nbv.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRAF2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRAF2
    SwitchGear 3'UTR luciferase reporter plasmidTRAF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRAF2
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF2
    Clone
    Products:
         
    OriGene clones in human, mouse for TRAF2 (see all 7)
    OriGene ORF clones in mouse, rat for TRAF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF2 (NM_021138)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRAF2
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF2
      QuantiTect SYBR Green Assays in human, mouse, rat TRAF2
      QuantiFast Probe-based Assays in human, mouse, rat TRAF2

    Additional mRNA sequence: 

    AK222961.1 AK289722.1 AK294607.1 AK298370.1 BC032410.1 BC033810.1 BC043492.1 BC064662.1 
    BX538160.1 HM991672.1 

    19 DOTS entries:

    DT.97845210  DT.101983141  DT.100822635  DT.100822631  DT.414361  DT.121167580  DT.95359979  DT.100822625 
    DT.100822626  DT.91655517  DT.91754463  DT.95168958  DT.121167548  DT.121167598  DT.40222126  DT.91754460 
    DT.97823964  DT.121167591  DT.40277325 

    Selected AceView cDNA sequences (see all 185):

    BM827828 BQ063815 CD630731 CR624454 BP872066 BQ057635 BI767443 CB530012 
    BU857656 CR611225 BU737890 BM467693 BQ186788 BU553823 T12587 NM_021138 
    CB106754 BG392688 CB133303 BC064662 BI093667 BM926917 BP873536 AA516370 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRAF2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -                                                                                 
    SP2:                                                                                                                  
    SP3:                                -                                                                                 
    SP4:                          -     -                                                                                 
    SP5:                                -           -                                                                     


    ECgene alternative splicing isoforms for TRAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRAF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGCAGAA
    TRAF2 Expression
    About this image


    TRAF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Dental Placode Cells Dental Placode
     
     Epithelial Cells
             Dental Placode Cells Dental Placode
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TRAF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522506
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF2 (see all 11): 
              NFKB Signaling Targets in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat
              p53 Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRAF2
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF2
    QuantiTect SYBR Green Assays in human, mouse, rat TRAF2
    QuantiFast Probe-based Assays in human, mouse, rat TRAF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf21 , 5 TNF receptor-associated factor 21, 5 83.57(n)1
    86.83(a)1
      2 (17.32 cM)5
    220301  NM_009422.21  NP_033448.21 
     255179825 
    chicken
    (Gallus gallus)
    Aves TRAF21 TNF receptor-associated factor 2 75.12(n)
    79.44(a)
      417287  XM_415560.3  XP_415560.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF26
    TNF receptor-associated factor 2
    57(a)
    1 ↔ 1
    GL343888.1(8280-25243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.104332 Xenopus laevis transcribed sequence with weak similarity more 80.16(n)    48045687 
    zebrafish
    (Danio rerio)
    Actinopterygii traf2a1 Tnf receptor-associated factor 2a 64.6(n)
    64.07(a)
      564295  XM_001924012.3  XP_001924047.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Traf-like6
    TNF-receptor-associated factor-like
    16(a)
    many ↔ many
    X(16309079-16311618)
    worm
    (Caenorhabditis elegans)
    Secernentea trf-16
    Protein TRF-1 (trf-1) mRNA, complete cds
    24(a)
    many ↔ many
    III(13430462-13433438) WBGene00006612


    ENSEMBL Gene Tree for TRAF2 (if available)
    TreeFam Gene Tree for TRAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRAF2 gene
    TRAF12  TRAF42  TRAF52  TRAF32  TRAF62  
    4 SIMAP similar genes for TRAF2 using alignment to 6 protein entries:     TRAF2_HUMAN (see all proteins):
    TRAF1    TRAF3    TRAF5    TRAF6

    TRAF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRAF2 (see all 1134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105330041,2
    C--109272167(+) tttat-/TTAA  
            
    tTAAT
    1 -- int10--------
    rs1819803981,2
    --139778986(+) CAGCCC/TGGGTG 1 -- us2k10--------
    rs784202791,2
    C--139779030(+) AAGAG-/AC/CA 
            
    AGGGT
    1 -- us2k11CSA 2
    rs285539411,2
    C--139779031(+) AGAGAC/GAGGGT 1 -- us2k10--------
    rs1843326531,2
    --139779152(+) TACAGA/GTGTGC 1 -- us2k10--------
    rs1169324761,2
    C,F--139781193(+) ACCAAG/ATCCGA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1380830321,2
    --139782121(+) CTCTCC/GCTGTT 1 -- int10--------
    rs1914100231,2
    --139782131(+) TAATAA/GCCCTA 1 -- int10--------
    rs2020422901,2
    C--139782155(+) GGAAC-/TGAATGT 1 -- int10--------
    rs764137061,2
    C,F--139782281(+) TATTAT/CTTTGA 1 -- int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for TRAF2 (139776364 - 139821067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRAF2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739398CNV Deletion23290073
    esv2739399CNV Deletion23290073
    esv2739400CNV Deletion23290073
    esv2422220CNV Deletion17116639
    esv2739397CNV Deletion23290073
    esv1600467CNV Insertion17803354
    nsv894483CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8423n71CNV Loss21882294
    dgv8418n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF2
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601895    OMIM disorders: --

    Selected diseases for TRAF2 (see all 54):    
    About MalaCards
    factor 2 deficiency    splenomegaly    malt lymphoma    retinopathy of prematurity
    oral lichen planus    patent ductus arteriosus    ectodermal dysplasia    lichen planus
    lupus nephritis    hepatitis c    atopy    vasculitis
    chronic lymphocytic leukemia    nephritis    b-cell chronic lymphocytic leukemia    lupus erythematosus
    b-cell lymphomas    kaposi's sarcoma    diffuse large b-cell lymphoma    glomerulonephritis


    TRAF2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TRAF2 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 81.3 101 9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 77)
    tumors 68.7 97 9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 73)
    malt lymphoma 56.6 1 16512826 (1)
    leukemia t-cell 35 1 10385526 (1)
    hodgkin disease 33.6 2 11144929 (1), 19336568 (1)
    inflammation 27.4 1 17158355 (1)
    lymphoma 24.2 2 14713952 (1), 18981220 (1)
    cancer 5.61 9 19336568 (2), 18981220 (1), 18794145 (1)
    lupus erythematosus systemic 0 2 18269865 (1)
    colon cancer 0 3 19243468 (3)

    Genetic Association Database (GAD): TRAF2
    Human Genome Epidemiology (HuGE) Navigator: TRAF2 (24 documents)

    Export disorders for TRAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRAF2 gene, integrated from 10 sources (see all 610):
    (articles sorted by number of sources associating them with TRAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. (PubMed id 7639698)1, 2, 3, 9 Song H.Y. and Donner D.B. (Biochem. J. 1995)
    2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)1, 2, 9 Zheng C.... Wu H. (Mol. Cell 2010)
    3. TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. (PubMed id 18981220)1, 2, 9 Blackwell K.... Habelhah H. (Mol. Cell. Biol. 2009)
    4. TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease. (PubMed id 18069092)1, 4, 9 Culpan D....Love S. (Neurobiol. Aging 2009)
    5. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. (PubMed id 19150425)1, 2, 9 Li S.... Dorf M.E. (Mol. Cell 2009)
    6. Structural basis for the lack of E2 interaction in the RING domain of TRAF2. (PubMed id 19810754)1, 2, 9 Yin Q.... Wu H. (Biochemistry 2009)
    7. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. (PubMed id 11907583)1, 2, 9 Li X.... Ashwell J.D. (Nature 2002)
    8. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. (PubMed id 10346818)1, 2, 9 Baud V.... Karin M. (Genes Dev. 1999)
    9. ASK1 is essential for JNK/SAPK activation by TRAF2. (PubMed id 9774977)1, 2, 9 Nishitoh H.... Ichijo H. (Mol. Cell 1998)
    10. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. (PubMed id 11784851)1, 2, 9 Chadee D.N.... Kyriakis J.M. (Mol. Cell. Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7186 HGNC: 12032 AceView: TRAF2 Ensembl:ENSG00000127191 euGenes: HUgn7186
    ECgene: TRAF2 Kegg: 7186 H-InvDB: TRAF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRAF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/traf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRAF2 gene:
    Search GeneIP for patents involving TRAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAF2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TRAF2 (TRAF-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRAF2   OriGene RNAi products in human, mouse, rat for TRAF2  
     OriGene qPCR primer pairs and template standards for TRAF2   OriGene Protein Over-expression Lysate for TRAF2  
     OriGene MassSpec something-or-other for TRAF2   OriGene clones in human, mouse for TRAF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRAF2   OriGene Purified Protein for TRAF2  
     OriGene ORF clones in mouse, rat for TRAF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRAF2   OriGene Custom Protein Services for TRAF2  

     
     
     Block miRNA regulation of human, mouse, rat TRAF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRAF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF2 Predesigned siRNA for gene silencing in human, mouse, rat TRAF2
     QuantiFast Probe-based Assays in human, mouse, rat TRAF2 QuantiTect SYBR Green Assays in human, mouse, rat TRAF2
     PCR Arrays including human, mouse, rat TRAF2 Search Chromatin IP Primers for TRAF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF2  GeneGlobe Interaction Network for TRAF2
     Regulatory tfbs in TRAF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRAF2 GenScript cDNA clones with any tag delivered in your preferred vector for TRAF2
     GenScript Custom Assay Services for TRAF2 GenScript Custom overexpressing Cell Line Services for TRAF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TRAF2 

     Search Tocris compounds for TRAF2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRAF2 antibodies
     TRAF2 proteins
     TRAF2 lysates
     Antibodies for TRAF2
     See all of Abcam's Antibodies, Kits and Proteins for TRAF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TRAF2
     Proteins for TRAF2
     Antibodies for TRAF2
     ELISAs for TRAF2
     CLIAs for TRAF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF2
     SwitchGear 3'UTR luciferase reporter plasmids for TRAF2
     SwitchGear Promoter luciferase reporter plasmids for TRAF2
     ThermoFisher Antibody for TRAF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF2
     LSBio Antibodies in human, mouse, rat for TRAF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRAF2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4