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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF2 Gene

protein-coding   GIFtS: 66
GCID: GC09P139776

TNF Receptor-Associated Factor 2

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNF Receptor-Associated Factor 21 2     MGC:450122
Tumor Necrosis Factor Type 2 Receptor-Associated Protein 32 3     TRAP2
TRAP32 3     Tumor Necrosis Factor Type 2 Receptor Associated Protein 32
E3 Ubiquitin-Protein Ligase TRAF22 3     EC 6.3.2.-3

External Ids:    HGNC: 120321   Entrez Gene: 71862   Ensembl: ENSG000001271917   OMIM: 6018955   UniProtKB: Q129333   

Export aliases for TRAF2 gene to outside databases

Previous GC identifers: GC09P131016 GC09P131470 GC09P133221 GC09P135138 GC09P137056 GC09P138900 GC09P109252


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRAF2 Gene:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This
protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein
and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated
apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the
degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only one transcript has been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TRAF2 Gene: 
TRAF2 (TNF receptor-associated factor 2) is a protein-coding gene. Diseases associated with TRAF2 include factor 2 deficiency, and malt lymphoma, and among its related super-pathways are DR3 Signaling and RANK Signaling in Osteoclasts. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is TRAF1.

UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival
and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase
activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an
essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of
target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein
levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2
RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR

Gene Wiki entry for TRAF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF2 gene promoter:
         AP-1   p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRAF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34

TRAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P139776:  view genomic region     (about GC identifiers)

Start:
139,776,364 bp from pter      End:
139,821,067 bp from pter
Size:
44,704 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933 (See protein sequence)
Recommended Name: TNF receptor-associated factor 2  
Size: 501 amino acids; 55859 Da
Subunit: Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type
and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4,
TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR,
TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and
IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1,
TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2,
NFATC2IP, PEG3 and HIVEP3. Interacts with ERN1; the interaction requires DAB2IP (By similarity). Interacts with
BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and
TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with
BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD,
USP48, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via 'Lys-63'-linked
polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated
under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Interacts
(via zinc fingers) with DAB2IP (via C-terminus PER domain); the interaction occurs in a TNF-alpha-dependent
manner. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with CARD14
Subcellular location: Cytoplasm
6/14 PDB 3D structures from and Proteopedia for TRAF2 (see all 14):
1CA4 (3D)        1CA9 (3D)        1CZY (3D)        1CZZ (3D)        1D00 (3D)        1D01 (3D)    
Secondary accessions: A8K107 B4DPJ7 Q7Z337 Q96NT2
Alternative splicing: 4 isoforms:  Q12933-1   Q12933-2   Q12933-3   Q12933-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF2: NX_Q12933

Explore proteomics data for TRAF2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in
    response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked
    polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for
    interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B
  • UniProtKB: Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked
    ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked
    polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys
    residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation.
    Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2,
    leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves
    'Lys-63'-linked polyubiquitin chains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12933

  • TRAF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRAF2 Protein Expression
    REFSEQ proteins: NP_066961.2  
    ENSEMBL proteins: 
     ENSP00000405860   ENSP00000406524   ENSP00000247668   ENSP00000397653   ENSP00000446414  
     ENSP00000352685  
    Reactome Protein details: Q12933
    Human Recombinant Protein Products for TRAF2: 
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    Novus Biologicals TRAF2 Proteins
    Novus Biologicals TRAF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TRAF2
    Cloud-Clone Corp. Proteins for TRAF2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0009898internal side of plasma membrane ISS--
    GO:0035631CD40 receptor complex ISS--

    TRAF2 for ontologies           About GeneDecksing



    TRAF2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAF2
    R&D Systems Antibodies for TRAF2 (TRAF-2)
    Cell Signaling Technology (CST) Antibodies for TRAF2 
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    OriGene Custom Antibody Services for TRAF2
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    Novus Biologicals TRAF2 Antibodies
    Abcam antibodies for TRAF2
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    LSBio Antibodies in human, mouse, rat for TRAF2 

    Assay Products for TRAF2: 
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    Cloud-Clone Corp. ELISAs for TRAF2 
    Cloud-Clone Corp. CLIAs for TRAF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/9 InterPro protein domains (see all 9):
     IPR008974 TRAF-like
     IPR017907 Znf_RING_CS
     IPR002083 MATH
     IPR001841 Znf_RING
     IPR027133 TRAF2

    Graphical View of Domain Structure for InterPro Entry Q12933

    ProtoNet protein and cluster: Q12933

    3 Blocks protein domains:
    IPB001293 Zn-finger
    IPB001841 Zn-finger
    IPB002083 Meprin/TRAF-like MATH


    UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
    Domain: The coiled coil domain mediates homo- and hetero-oligomerization
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not
    essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling
    Similarity: Belongs to the TNF receptor-associated factor family. A subfamily
    Similarity: Contains 1 MATH domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 2 TRAF-type zinc fingers


    TRAF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF2_HUMAN, Q12933
    Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival
    and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase
    activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an
    essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of
    target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein
    levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2
    RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR
    Enzyme regulation: Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3
    ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate

         Genatlas biochemistry entry for TRAF2:
    tumor necrosis factor (TNF)- receptor-associated factor,variably expressed in heart,liver,placenta,brain,skeletal
    muscle,kidney,pancreas,intestinal epithelial cells,potentiial mediator of CD40 (TNFRSF5) and TNFR2
    signaling,involved in both IL1B and TNF/alpha signaling cascades,implicated in TNFR-mediated NF-kappa B
    activation in association with MAPK8

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15258597
    GO:0004871signal transducer activity NAS8702708
    GO:0005164tumor necrosis factor receptor binding IPI11279055
    GO:0005174CD40 receptor binding ISS--
    GO:0005515protein binding IPI10514511
         
    TRAF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRAF2:
     Downregulation of NF-kappaB pa  Increased cell death HMECs cel 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Traf2):
     adipose tissue  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle 

    TRAF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRAF2: Traf2tm1.1Rbr Traf2tm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRAF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRAF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF2 

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    Inhib. RNA
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TRAF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRAF2 (NM_021138)
    Browse Sino Biological Human cDNA Clones
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRAF2 About   (see all 52)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    TRAIL Pathway0.40
    2BAFF in B-Cell Signaling
    BAFF in B-Cell Signaling0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    APRIL Pathway0.92
    RANK Pathway0.38
    RANK Signaling in Osteoclasts0.45
    RANKL/RANK Signaling Pathway0.31
    3RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52
    4MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    5Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Lymphotoxin-beta receptor signaling0.46
    LT-BetaR Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for TRAF2 (see all 9)
        Immune response IL-9 signaling pathway
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Transcription NF-kB signaling pathway
    Apoptosis and survival TNFR1 signaling pathway

    1 R&D Systems Pathway for TRAF2
        Apoptosis Signaling Pathways

    5/36 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF2 (see all 36)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for TRAF2
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for TRAF2 (see all 9)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival Lymphotoxin-beta receptor signaling
    Apoptosis and survival TNFR1 signaling pathway

    5/14 BioSystems Pathways for TRAF2 (see all 14)
        MAPK signaling pathway
    Apoptosis
    p38 MAPK Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    RANKL/RANK Signaling Pathway

    5/12        Reactome Pathways for TRAF2 (see all 12)
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF6 mediated IRF7 activation
    TRAF6 mediated NF-kB activation
    Apoptosis
    Death Receptor Signalling


    5/15         Kegg Pathways  (Kegg details for TRAF2) (see all 15):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Protein processing in endoplasmic reticulum
    Apoptosis
    Osteoclast differentiation

    UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933
    Pathway: Protein modification; protein ubiquitination


    TRAF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/469 Interacting proteins for TRAF2 (Q129331, 2, 3 ENSP000002476684) via UniProtKB, MINT, STRING, and/or I2D (see all 469)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002726positive regulation of T cell cytokine production IMP15125833
    GO:0006461protein complex assembly TAS8702708
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007165signal transduction TAS8702708

    TRAF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TRAF2

    10/19 Novoseek inferred chemical compound relationships for TRAF2 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ciap1 82.1 16 16282325 (6), 18827186 (3), 20053756 (2), 15265700 (1)
    tab-1 68.4 4 19966933 (1), 17439942 (1), 17633026 (1), 17673602 (1)
    sb 203580 39.3 1 10823821 (1)
    leptomycin b 28.2 1 11801607 (1)
    bortezomib 27.9 1 16024631 (1)
    zinc 24.4 10 19810754 (2), 9647239 (1), 14713952 (1), 15545599 (1) (see all 8)
    threonine 17.7 1 10477597 (1)
    n acetylcysteine 13.8 1 10788610 (1)
    cycloheximide 9.8 1 9813034 (1)
    phosphatidylinositol 8.81 2 15115707 (2)

    Search CenterWatch for drugs/clinical trials and news about TRAF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRAF2 gene: 
    NM_021138.3  

    Unigene Cluster for TRAF2:

    TNF receptor-associated factor 2
    Hs.522506  [show with all ESTs]
    Unigene Representative Sequence: BC064662
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419057 ENST00000429509 ENST00000247668(uc010nbu.3 uc004cjv.3 uc011mek.2 uc010nbw.3)
    ENST00000414589 ENST00000474950 ENST00000482854 ENST00000469701 ENST00000466107
    ENST00000536468 ENST00000359662(uc010nbv.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK222961.1 AK289722.1 AK294607.1 AK298370.1 BC032410.1 BC033810.1 BC043492.1 BC064662.1 
    BX538160.1 HM991672.1 

    19 DOTS entries:

    DT.97845210  DT.101983141  DT.100822635  DT.100822631  DT.414361  DT.121167580  DT.95359979  DT.100822625 
    DT.100822626  DT.91655517  DT.91754463  DT.95168958  DT.121167548  DT.121167598  DT.40222126  DT.91754460 
    DT.97823964  DT.121167591  DT.40277325 

    24/185 AceView cDNA sequences (see all 185):

    BM467693 BC064662 CB139778 BM785733 NM_021138 CR611225 CB153051 CR624454 
    BI093667 T12587 CD630731 BQ057635 BP873536 CB530012 BQ226491 AU279730 
    AU131396 BU553823 BG392688 BQ055676 BM827828 BU737890 BQ063815 BI767443 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -                                                                                 
    SP2:                                                                                                                  
    SP3:                                -                                                                                 
    SP4:                          -     -                                                                                 
    SP5:                                -           -                                                                     


    ECgene alternative splicing isoforms for TRAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGCAGAA
    TRAF2 Expression
    About this image


    See TRAF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF2

    SOURCE GeneReport for Unigene cluster: Hs.522506
        SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF2 (see all 11): 
              NFKB Signaling Targets in human mouse rat
              Apoptosis in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat
              p53 Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TRAF2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf21 , 5 TNF receptor-associated factor 21, 5 83.57(n)1
    86.83(a)1
      2 (17.32 cM)5
    220301  NM_009422.21  NP_033448.21 
     255179825 
    chicken
    (Gallus gallus)
    Aves TRAF21 TNF receptor-associated factor 2 75.12(n)
    79.44(a)
      417287  XM_415560.2  XP_415560.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF26
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343888.1(8280-25243)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.104332 Xenopus laevis transcribed sequence with weak similarity more 80.16(n)    48045687 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000054461 TNF receptor-associated factor 2-like 65(n)
    63.27(a)
      100005446  XM_001344465.3  XP_001344501.3 
    worm
    (Caenorhabditis elegans)
    Secernentea trf-16
    Y110A7A.26
    Protein Y110A7A.2
    24(a)
    19(a)
    possible ortholog
    possible ortholog
    III(13430462-13433438)
    I(5154529-5158467)


    ENSEMBL Gene Tree for TRAF2 (if available)
    TreeFam Gene Tree for TRAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF2 gene
    TRAF12  TRAF42  TRAF52  TRAF32  TRAF62  
    4 SIMAP similar genes for TRAF2 using alignment to 6 protein entries:     TRAF2_HUMAN (see all proteins):
    TRAF1    TRAF3    TRAF5    TRAF6

    TRAF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1134 SNPs in TRAF2 are shown (see all 1134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105330041,2
    C--109272167(+) tttat-/TTAA  
            
    tTAAT
    1 -- int10--------
    rs1819803981,2
    --139778986(+) CAGCCC/TGGGTG 1 -- us2k10--------
    rs784202791,2
    C--139779030(+) AAGAG-/AC/CA 
            
    AGGGT
    1 -- us2k11CSA 2
    rs285539411,2
    C--139779031(+) AGAGAC/GAGGGT 1 -- us2k10--------
    rs1843326531,2
    --139779152(+) TACAGA/GTGTGC 1 -- us2k10--------
    rs1169324761,2
    C,F--139781193(+) ACCAAG/ATCCGA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1380830321,2
    --139782121(+) CTCTCC/GCTGTT 1 -- int10--------
    rs1914100231,2
    --139782131(+) TAATAA/GCCCTA 1 -- int10--------
    rs2020422901,2
    C--139782155(+) GGAAC-/TGAATGT 1 -- int10--------
    rs764137061,2
    C,F--139782281(+) TATTAT/CTTTGA 1 -- int11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for TRAF2 (139776364 - 139821067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for TRAF2 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739398CNV Deletion23290073
    esv2739399CNV Deletion23290073
    esv2739400CNV Deletion23290073
    esv2422220CNV Deletion17116639
    esv2739397CNV Deletion23290073
    esv1600467CNV Insertion17803354
    nsv894483CNV Loss21882294
    dgv8416n71CNV Loss21882294
    dgv8423n71CNV Loss21882294
    dgv8418n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601895    OMIM disorders: --

    20/50 diseases for TRAF2 (see all 50):    About MalaCards
    factor 2 deficiency    malt lymphoma    splenomegaly    retinopathy of prematurity
    oral lichen planus    lichen planus    patent ductus arteriosus    ectodermal dysplasia
    lupus nephritis    vasculitis    nephritis    atopy
    hepatitis c    b-cell chronic lymphocytic leukemia    b-cell lymphomas    diffuse large b-cell lymphoma
    glomerulonephritis    lupus erythematosus    glioblastoma    kaposi's sarcoma


    TRAF2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/19 Novoseek inferred disease relationships for TRAF2 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 81.3 101 9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 77)
    tumors 68.7 97 9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 73)
    malt lymphoma 56.6 1 16512826 (1)
    leukemia t-cell 35 1 10385526 (1)
    hodgkin disease 33.6 2 11144929 (1), 19336568 (1)
    inflammation 27.4 1 17158355 (1)
    lymphoma 24.2 2 14713952 (1), 18981220 (1)
    cancer 5.61 9 19336568 (2), 18981220 (1), 18794145 (1)
    lupus erythematosus systemic 0 2 18269865 (1)
    colon cancer 0 3 19243468 (3)

    Genetic Association Database (GAD): TRAF2
    Human Genome Epidemiology (HuGE) Navigator: TRAF2 (24 documents)

    Export disorders for TRAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF2 gene, integrated from 9 sources (see all 596):
    (articles sorted by number of sources associating them with TRAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. (PubMed id 7639698)1, 2, 3, 9 Song H.Y. and Donner D.B. (1995)
    2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)1, 2, 9 Zheng C....Wu H. (2010)
    3. TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. (PubMed id 18981220)1, 2, 9 Blackwell K....Habelhah H. (2009)
    4. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. (PubMed id 19150425)1, 2, 9 Li S....Dorf M.E. (2009)
    5. TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease. (PubMed id 18069092)1, 4, 9 Culpan D....Love S. (2007)
    6. Structural basis for the lack of E2 interaction in th e RING domain of TRAF2. (PubMed id 19810754)1, 2, 9 Yin Q....Wu H. (2009)
    7. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. (PubMed id 11907583)1, 2, 9 Li X....Ashwell J.D. (2002)
    8. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. (PubMed id 10346818)1, 2, 9 Baud V.... Karin M. (1999)
    9. ASK1 is essential for JNK/SAPK activation by TRAF2. (PubMed id 9774977)1, 2, 9 Nishitoh H.... Ichijo H. (1998)
    10. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. (PubMed id 11784851)1, 2, 9 Chadee D.N.... Kyriakis J.M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7186 HGNC: 12032 AceView: TRAF2 Ensembl:ENSG00000127191 euGenes: HUgn7186
    ECgene: TRAF2 Kegg: 7186 H-InvDB: TRAF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF2 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/traf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRAF2 gene:
    Search GeneIP for patents involving TRAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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