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Aliases for TRAF2 Gene

Aliases for TRAF2 Gene

  • TNF Receptor Associated Factor 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRAF2 3 4
  • E3 Ubiquitin-Protein Ligase TRAF2 3 4
  • TRAP3 3 4
  • Tumor Necrosis Factor Type 2 Receptor Associated Protein 3 3
  • Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3 4
  • TNF Receptor-Associated Factor 2 3
  • EC 2.3.2.27 4
  • MGC:45012 3
  • TRAP 3

External Ids for TRAF2 Gene

Previous GeneCards Identifiers for TRAF2 Gene

  • GC09P131016
  • GC09P131470
  • GC09P133221
  • GC09P135138
  • GC09P137056
  • GC09P138900
  • GC09P139776
  • GC09P109252

Summaries for TRAF2 Gene

Entrez Gene Summary for TRAF2 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAF2 Gene

TRAF2 (TNF Receptor Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include Salivary Gland Cancer and Lymphoma, Malt, Somatic. Among its related pathways are TRAF Pathway and RANK Signaling in Osteoclasts. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is TRAF3.

UniProtKB/Swiss-Prot for TRAF2 Gene

  • Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Gene Wiki entry for TRAF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF2 Gene

Genomics for TRAF2 Gene

Regulatory Elements for TRAF2 Gene

Enhancers for TRAF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136925 1.3 Ensembl ENCODE dbSUPER 17.9 +45.3 45340 3.5 HDGF CTCF PKNOX1 ESRRA RAD21 FOSL1 ZFHX2 ZNF316 GATA2 POLR2A LCN12 TRAF2 CCDC183 PRR31 PHPT1 MAMDC4 C9orf172 RABL6 CCDC183-AS1 LCNL1
GH09G136900 1.4 Ensembl ENCODE dbSUPER 12.8 +20.3 20263 4.0 ELF3 HDGF TBP PKNOX1 FOXA2 SIN3A RAD21 ZBTB40 YY1 EGR1 TRAF2 TMEM141 PHPT1 LCN12 C9orf142 SAPCD2 MIR4479 PIR43412
GH09G136839 1.3 ENCODE dbSUPER 12.6 -40.2 -40159 4.5 HDGF PKNOX1 AGO1 ARID4B SIN3A ZNF2 ZNF207 ZNF143 KLF13 DEK TRAF2 RABL6 CCDC183 PHPT1 C9orf172 MIR4292
GH09G136932 0.9 FANTOM5 ENCODE 13.4 +50.4 50392 0.2 ZNF316 MAFG NFE2 EMSY MAFK NFE2L2 TRAF2 PHPT1 MAMDC4 C9orf172 RABL6 CCDC183 CCDC183-AS1 LCNL1 NDOR1 NOTCH1
GH09G137410 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.3 +530.3 530317 3.4 HDGF GLIS2 FOS CAVIN1 ZNF592 SMARCA4 GLIS1 KDM1A KLF1 BACH1 NOXA1 TRAF2 NRARP EXD3 GC09M137332
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRAF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAF2 Gene

Chromosome:
9
Start:
136,881,912 bp from pter
End:
136,926,621 bp from pter
Size:
44,710 bases
Orientation:
Plus strand

Genomic View for TRAF2 Gene

Genes around TRAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF2 Gene

Proteins for TRAF2 Gene

  • Protein details for TRAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12933-TRAF2_HUMAN
    Recommended name:
    TNF receptor-associated factor 2
    Protein Accession:
    Q12933
    Secondary Accessions:
    • A8K107
    • B4DPJ7
    • Q7Z337
    • Q96NT2

    Protein attributes for TRAF2 Gene

    Size:
    501 amino acids
    Molecular mass:
    55859 Da
    Quaternary structure:
    • Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with ERN1; the interaction requires DAB2IP. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via Lys-63-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain); the interaction occurs in a TNF-alpha-dependent manner. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with CARD14. Interacts with PTPN2; probably involved in tumor necrosis factor-mediated signaling.

    Three dimensional structures from OCA and Proteopedia for TRAF2 Gene

    Alternative splice isoforms for TRAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF2 Gene

Post-translational modifications for TRAF2 Gene

  • Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for Lys-63-linked polyubiquitination, but not for Lys-48-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B.
  • Undergoes both Lys-48-linked and Lys-63-linked polyubiquitination. Polyubiquitinated via Lys-63-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. Lys-63-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via Lys-48-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves Lys-63-linked polyubiquitin chains.
  • Ubiquitination at isoforms=2, 3, 421, posLast=3131, Lys140, Lys176, posLast=255255, Lys313, posLast=320320, Lys331, and Lys481
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF2 (TRAF2)

No data available for DME Specific Peptides for TRAF2 Gene

Domains & Families for TRAF2 Gene

Suggested Antigen Peptide Sequences for TRAF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q12933

UniProtKB/Swiss-Prot:

TRAF2_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • Belongs to the TNF receptor-associated factor family. A subfamily.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling.
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.
genes like me logo Genes that share domains with TRAF2: view

Function for TRAF2 Gene

Molecular function for TRAF2 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)- receptor-associated factor,variably expressed in heart,liver,placenta,brain,skeletal muscle,kidney,pancreas,intestinal epithelial cells,potentiial mediator of CD40 (TNFRSF5) and TNFR2 signaling,involved in both IL1B and TNF/alpha signaling cascades,implicated in TNFR-mediated NF-kappa B activation in association with MAPK8
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate.
UniProtKB/Swiss-Prot Function:
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Enzyme Numbers (IUBMB) for TRAF2 Gene

Gene Ontology (GO) - Molecular Function for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,IDA 15258597
GO:0004871 signal transducer activity NAS 8702708
GO:0005102 receptor binding IEA --
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005174 CD40 receptor binding ISS --
genes like me logo Genes that share ontologies with TRAF2: view
genes like me logo Genes that share phenotypes with TRAF2: view

Animal Models for TRAF2 Gene

MGI Knock Outs for TRAF2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF2 Gene

Localization for TRAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAF2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 17314283
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRAF2: view

Pathways & Interactions for TRAF2 Gene

SuperPathways for TRAF2 Gene

genes like me logo Genes that share pathways with TRAF2: view

UniProtKB/Swiss-Prot Q12933-TRAF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRAF2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002726 positive regulation of T cell cytokine production IMP 15125833
GO:0006461 protein complex assembly TAS 8702708
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 8702708
genes like me logo Genes that share ontologies with TRAF2: view

Drugs & Compounds for TRAF2 Gene

(10) Drugs for TRAF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for TRAF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF2: view

Transcripts for TRAF2 Gene

Unigene Clusters for TRAF2 Gene

TNF receptor-associated factor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRAF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for TRAF2 Gene

GeneLoc Exon Structure for
TRAF2
ECgene alternative splicing isoforms for
TRAF2

Expression for TRAF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF2 Gene

This gene is overexpressed in Lung (16.5), Peripheral blood mononuclear cells (13.0), and Urine (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAF2 Gene



Protein tissue co-expression partners for TRAF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAF2 Gene:

TRAF2

SOURCE GeneReport for Unigene cluster for TRAF2 Gene:

Hs.522506

Evidence on tissue expression from TISSUES for TRAF2 Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Kidney(4.4)
  • Spleen(4.3)
  • Intestine(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with TRAF2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAF2 Gene

Orthologs for TRAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF2 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia TRAF2 34 35
  • 86.56 (n)
cow
(Bos Taurus)
Mammalia TRAF2 34 35
  • 85.5 (n)
rat
(Rattus norvegicus)
Mammalia Traf2 34
  • 84.1 (n)
mouse
(Mus musculus)
Mammalia Traf2 34 16 35
  • 83.57 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAF2 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF2 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAF2 34 35
  • 75.12 (n)
lizard
(Anolis carolinensis)
Reptilia TRAF2 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia traf2 34
  • 68.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10433 34
zebrafish
(Danio rerio)
Actinopterygii BX901915.1 35
  • 65 (a)
OneToMany
TRAF2 (3 of 3) 35
  • 65 (a)
OneToMany
traf2a 34
  • 64.6 (n)
traf2b 35
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7990 34
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 35
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 35
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
ManyToMany
Species where no ortholog for TRAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF2 Gene

ENSEMBL:
Gene Tree for TRAF2 (if available)
TreeFam:
Gene Tree for TRAF2 (if available)

Paralogs for TRAF2 Gene

Paralogs for TRAF2 Gene

(4) SIMAP similar genes for TRAF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRAF2: view

Variants for TRAF2 Gene

Sequence variations from dbSNP and Humsavar for TRAF2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000042028 -- 136,917,399(+) TCCAG(G/T)TGGAC intron-variant
rs1000065492 -- 136,901,904(+) CCTGG(A/C)CACAC intron-variant
rs1000120872 -- 136,881,044(+) ATCAC(G/T)CCCGG upstream-variant-2KB
rs1000120925 -- 136,887,871(+) GTAAT(-/TTTA)TTTAT intron-variant, upstream-variant-2KB
rs1000127897 -- 136,891,824(+) TCAAG(C/T)GATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF2 Gene

Variant ID Type Subtype PubMed ID
esv1600467 CNV insertion 17803354
esv2422220 CNV deletion 17116639
esv2739397 CNV deletion 23290073
esv2739398 CNV deletion 23290073
esv2739399 CNV deletion 23290073
esv2739400 CNV deletion 23290073
esv2759720 CNV loss 17122850
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv615986 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv951205 CNV deletion 24416366

Variation tolerance for TRAF2 Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF2 Gene

Disorders for TRAF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAF2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
salivary gland cancer
  • malignant neoplasm of major salivary gland
lymphoma, malt, somatic
  • lymphoma, mucosa-associated lymphoid type
- elite association - COSMIC cancer census association via MalaCards
Search TRAF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAF2

Genetic Association Database (GAD)
TRAF2
Human Genome Epidemiology (HuGE) Navigator
TRAF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF2
genes like me logo Genes that share disorders with TRAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF2 Gene

Publications for TRAF2 Gene

  1. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. (PMID: 7639698) Song H.Y. … Donner D.B. (Biochem. J. 1995) 2 3 4 22 64
  2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PMID: 20385093) Zheng C. … Wu H. (Mol. Cell 2010) 3 4 22 64
  3. The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB. (PMID: 20064526) Zhang L. … Habelhah H. (J. Mol. Biol. 2010) 3 4 22 64
  4. TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. (PMID: 18981220) Blackwell K. … Habelhah H. (Mol. Cell. Biol. 2009) 3 4 22 64
  5. PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. (PMID: 19150425) Li S. … Dorf M.E. (Mol. Cell 2009) 3 4 22 64

Products for TRAF2 Gene

Sources for TRAF2 Gene

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