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Aliases for TRAF2 Gene

Aliases for TRAF2 Gene

  • TNF Receptor-Associated Factor 2 2 3
  • Tumor Necrosis Factor Type 2 Receptor-Associated Protein 3 3 4
  • E3 Ubiquitin-Protein Ligase TRAF2 3 4
  • TRAP3 3 4
  • Tumor Necrosis Factor Type 2 Receptor Associated Protein 3 3
  • EC 6.3.2.- 4
  • MGC:45012 3
  • TRAP 3

External Ids for TRAF2 Gene

Summaries for TRAF2 Gene

Entrez Gene Summary for TRAF2 Gene

  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAF2 Gene

TRAF2 (TNF Receptor-Associated Factor 2) is a Protein Coding gene. Diseases associated with TRAF2 include factor 2 deficiency. Among its related pathways are MAPK signaling pathway and Pathways in cancer. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF2 Gene

  • Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Gene Wiki entry for TRAF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF2 Gene

Genomics for TRAF2 Gene

Genomic Location for TRAF2 Gene

Start:
136,881,912 bp from pter
End:
136,926,615 bp from pter
Size:
44,704 bases
Orientation:
Plus strand

Genomic View for TRAF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF2 Gene

Regulatory Elements for TRAF2 Gene

Proteins for TRAF2 Gene

  • Protein details for TRAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12933-TRAF2_HUMAN
    Recommended name:
    TNF receptor-associated factor 2
    Protein Accession:
    Q12933
    Secondary Accessions:
    • A8K107
    • B4DPJ7
    • Q7Z337
    • Q96NT2

    Protein attributes for TRAF2 Gene

    Size:
    501 amino acids
    Molecular mass:
    55859 Da
    Quaternary structure:
    • Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with ERN1; the interaction requires DAB2IP. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts (via Lys-63-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation. Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain); the interaction occurs in a TNF-alpha-dependent manner. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain). Interacts with CARD14. Interacts with PTPN2; probably involved in tumor necrosis factor-mediated signaling.

    Three dimensional structures from OCA and Proteopedia for TRAF2 Gene

    Alternative splice isoforms for TRAF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF2 Gene

Proteomics data for TRAF2 Gene at MOPED

Post-translational modifications for TRAF2 Gene

  • Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for Lys-63-linked polyubiquitination, but not for Lys-48-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B.
  • Undergoes both Lys-48-linked and Lys-63-linked polyubiquitination. Polyubiquitinated via Lys-63-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. Lys-63-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via Lys-48-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Deubiquitinated by CYLD, a protease that specifically cleaves Lys-63-linked polyubiquitin chains.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys27, Lys31, Lys140, Lys176, Lys255, Lys313, Lys320, Lys331, and Lys481

Other Protein References for TRAF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAF2 Gene

Domains for TRAF2 Gene

Gene Families for TRAF2 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

TRAF2_HUMAN
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.:
    • Q12933
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.:
    • Q12933
  • The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential for the stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signaling.:
    • Q12933
  • Contains 1 MATH domain.:
    • Q12933
Family:
  • Belongs to the TNF receptor-associated factor family. A subfamily.:
    • Q12933
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q12933
  • Contains 2 TRAF-type zinc fingers.:
    • Q12933
genes like me logo Genes that share domains with TRAF2: view

Function for TRAF2 Gene

Molecular function for TRAF2 Gene

GENATLAS Biochemistry: tumor necrosis factor (TNF)- receptor-associated factor,variably expressed in heart,liver,placenta,brain,skeletal muscle,kidney,pancreas,intestinal epithelial cells,potentiial mediator of CD40 (TNFRSF5) and TNFR2 signaling,involved in both IL1B and TNF/alpha signaling cascades,implicated in TNFR-mediated NF-kappa B activation in association with MAPK8
UniProtKB/Swiss-Prot EnzymeRegulation: Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitin ligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate.
UniProtKB/Swiss-Prot Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Enzyme Numbers (IUBMB) for TRAF2 Gene

Gene Ontology (GO) - Molecular Function for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 15258597
GO:0004871 signal transducer activity NAS 8702708
GO:0005102 receptor binding --
GO:0005164 tumor necrosis factor receptor binding IPI 11279055
GO:0005174 CD40 receptor binding ISS --
genes like me logo Genes that share ontologies with TRAF2: view
genes like me logo Genes that share phenotypes with TRAF2: view

Animal Models for TRAF2 Gene

MGI Knock Outs for TRAF2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TRAF2 Gene

Localization for TRAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAF2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF2 Gene COMPARTMENTS Subcellular localization image for TRAF2 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 17314283
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005938 cell cortex IEA --
GO:0009898 cytoplasmic side of plasma membrane ISS --
genes like me logo Genes that share ontologies with TRAF2: view

Pathways for TRAF2 Gene

genes like me logo Genes that share pathways with TRAF2: view

UniProtKB/Swiss-Prot Q12933-TRAF2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002726 positive regulation of T cell cytokine production IMP 15125833
GO:0006461 protein complex assembly TAS 8702708
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 8702708
genes like me logo Genes that share ontologies with TRAF2: view

Compounds for TRAF2 Gene

(19) Novoseek inferred chemical compound relationships for TRAF2 Gene

Compound -log(P) Hits PubMed IDs
ciap1 82.1 12
tab-1 68.4 4
sb 203580 39.3 1
leptomycin b 28.2 1
bortezomib 27.9 1
genes like me logo Genes that share compounds with TRAF2: view

Transcripts for TRAF2 Gene

Unigene Clusters for TRAF2 Gene

TNF receptor-associated factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: -
SP4: - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for TRAF2 Gene

GeneLoc Exon Structure for
TRAF2
ECgene alternative splicing isoforms for
TRAF2

Expression for TRAF2 Gene

mRNA expression in normal human tissues for TRAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF2 Gene

SOURCE GeneReport for Unigene cluster for TRAF2 Gene Hs.522506

genes like me logo Genes that share expressions with TRAF2: view

Orthologs for TRAF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF2 36
  • 99.14 (n)
  • 99.4 (a)
TRAF2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAF2 36
  • 85.5 (n)
  • 88.62 (a)
TRAF2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAF2 36
  • 86.56 (n)
  • 90.82 (a)
TRAF2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf2 36
  • 83.57 (n)
  • 86.83 (a)
Traf2 16
Traf2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAF2 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF2 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf2 36
  • 84.1 (n)
  • 87.32 (a)
chicken
(Gallus gallus)
Aves TRAF2 36
  • 75.12 (n)
  • 79.44 (a)
TRAF2 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF2 37
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10433 36
tropical clawed frog
(Silurana tropicalis)
Amphibia traf2 36
  • 68.6 (n)
  • 66.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7990 36
zebrafish
(Danio rerio)
Actinopterygii BX901915.1 37
  • 65 (a)
OneToMany
TRAF2 (3 of 3) 37
  • 65 (a)
OneToMany
traf2a 36
  • 64.6 (n)
  • 64.07 (a)
traf2b 37
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 37
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 37
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
ManyToMany
Species with no ortholog for TRAF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAF2 Gene

ENSEMBL:
Gene Tree for TRAF2 (if available)
TreeFam:
Gene Tree for TRAF2 (if available)

Paralogs for TRAF2 Gene

Paralogs for TRAF2 Gene

Selected SIMAP similar genes for TRAF2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TRAF2: view

Variants for TRAF2 Gene

Sequence variations from dbSNP and Humsavar for TRAF2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1537795 -- 136,897,232(+) CTGGA(C/G/T)GATGC intron-variant, upstream-variant-2KB
rs1800631 -- 136,899,393(-) CGTTT(G/T)TGAGG intron-variant
rs2784032 -- 136,893,326(-) ACCTT(A/G)CATTC intron-variant
rs2784033 -- 136,893,203(-) GGGGA(C/G)GCCAC intron-variant
rs2784069 -- 136,888,840(-) GGGCC(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF2 Gene

Variant ID Type Subtype PubMed ID
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
dgv2427e1 CNV Complex 17122850
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv818738 CNV Gain 17921354
dgv8417n71 CNV Loss 21882294
dgv8418n71 CNV Loss 21882294
dgv8419n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8422n71 CNV Gain 21882294
esv2739397 CNV Deletion 23290073
esv2739398 CNV Deletion 23290073
esv1600467 CNV Insertion 17803354
esv2739399 CNV Deletion 23290073
nsv894497 CNV Gain 21882294
dgv8423n71 CNV Loss 21882294
esv2739400 CNV Deletion 23290073

Relevant External Links for TRAF2 Gene

HapMap Linkage Disequilibrium report
TRAF2

Disorders for TRAF2 Gene

(1) MalaCards Diseases for TRAF2 Gene

Search for TRAF2 Gene in MalaCards »

(19) Novoseek inferred disease relationships for TRAF2 Gene

Disease -log(P) Hits PubMed IDs
necrosis 81.3 84
tumors 68.7 81
malt lymphoma 56.6 1
leukemia t-cell 35 1
hodgkin disease 33.6 2

Relevant External Links for TRAF2

Genetic Association Database (GAD)
TRAF2
Human Genome Epidemiology (HuGE) Navigator
TRAF2
genes like me logo Genes that share disorders with TRAF2: view

No data available for UniProtKB/Swiss-Prot for TRAF2 Gene

Publications for TRAF2 Gene

  1. Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. (PMID: 7639698) Song H.Y. … Donner D.B. (Biochem. J. 1995) 2 3 4 23
  2. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PMID: 8069916) Rothe M. … Goeddel D.V. (Cell 1994) 3 4 23
  3. Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5- mediated NF-kappaB activation. (PMID: 9488716) Kawamata S. … Uchiyama T. (J. Biol. Chem. 1998) 3 4 23
  4. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PMID: 9718306) Pullen S.S. … Kehry M.R. (Biochemistry 1998) 3 4 23
  5. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. (PMID: 9774460) Wong B.R. … Choi Y. (J. Biol. Chem. 1998) 3 4 23

Products for TRAF2 Gene

  • Addgene plasmids for TRAF2

Sources for TRAF2 Gene

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