TRAF2 Gene
protein-coding GIFtS: 66
GCID: GC09P139776
|
|
TNF receptor-associated factor 2
| |
Aliases
for TRAF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TNF Receptor-Associated Factor 21 2 | | MGC:450122 | | TRAP31 2 3 | | TRAP2 | | Tumor Necrosis Factor Type 2 Receptor-Associated Protein 32 3 | | Tumor Necrosis Factor Type 2 Receptor Associated Protein 32 | | E3 Ubiquitin-Protein Ligase TRAF22 3 | | EC 6.3.2.-3 |
Export aliases for TRAF2 gene to outside databasesPrevious GC identifers: GC09P131016 GC09P131470 GC09P133221 GC09P135138 GC09P137056 GC09P138900 GC09P109252 |
Summaries
for TRAF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRAF2:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from members of the TNF receptor superfamily. This proteindirectly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signalsfrom TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer,ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitorpossessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thuspotentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene,but the biological validity of only one transcript has been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival andapoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activityand promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essentialconstituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteinsby bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibitingtheir autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain
Gene Wiki entry for TRAF2
|
Genomic Views
for TRAF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRAF2 gene promoter:
AP-1 p53 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRAF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34TRAF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P139776: view genomic region
(about GC identifiers)
Start:
|
139,776,364 bp from pter |
End:
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139,821,067 bp from pter |
Size:
|
44,704 bases |
Orientation:
|
plus strand |
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Proteins
for TRAF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933 (See
protein sequence)Recommended Name: TNF receptor-associated factor 2 Size: 501 amino acids; 55859 Da
Subunit: Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type andthe first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4,TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR,TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA.Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1,TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3(By similarity). Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with aheterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2and BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B.Interacts with CYLD, USP48, DAB2IP, IKKA and IKKB. Identified in a complex with TNFRSF1A, RIPK1 and IKKB. Interacts(via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3. Interacts with ERN1 and TAOK3. Interaction with TAOK3is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation
Subcellular location: Cytoplasm
6/14 PDB 3D structures from  and Proteopedia  for TRAF2 (see all 14):1CA4 (3D)
1CA9 (3D)
1CZY (3D)
1CZZ (3D)
1D00 (3D)
1D01 (3D)
Secondary accessions: A8K107 B4DPJ7 Q7Z337 Q96NT2Alternative splicing: 4 isoforms: Q12933-1 Q12933-2 Q12933-3 Q12933-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRAF2: NX_Q12933
Post-translational modifications:
Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 inresponse to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linkedpolyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important forinteraction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B1
Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked ubiquitinin response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked polyubiquitinationpromotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via 'Lys-48'-linkedubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to itssubsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomaldegradation. Deubiquitinated by CYLD, a protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12933
TRAF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066961.2
ENSEMBL proteins: ENSP00000405860 ENSP00000406524 ENSP00000247668 ENSP00000360708 ENSP00000397653 ENSP00000446414 ENSP00000352685 Reactome Protein details: Q12933
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TRAF2 for ontologies About GeneDecksing
TRAF2 Antibody Products:
Assay Products for TRAF2: |
Protein
Domains /
Families
for TRAF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRAF2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q12933ProtoNet protein and cluster: Q12933 3 Blocks protein families: IPB001293 Zn-finger IPB001841 Zn-finger IPB002083 Meprin/TRAF-like MATH
UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933Domain: The coiled coil domain mediates homo- and hetero-oligomerizationDomain: The MATH/TRAF domain binds to receptor cytoplasmic domainsDomain: The RING-type zinc finger domain is essential for E3 ubiquitin-protein ligase activity. It is not essential forthe stabilization of BIRC2, or for the ubiquitination of RIPK1 in response to TNFR1 signalingSimilarity: Belongs to the TNF receptor-associated factor family. A subfamilySimilarity: Contains 1 MATH domainSimilarity: Contains 1 RING-type zinc fingerSimilarity: Contains 2 TRAF-type zinc fingers |
Function
for TRAF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933Function: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival andapoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activityand promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essentialconstituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteinsby bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibitingtheir autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domainEnzyme regulation: Has very low E3 ubiquitin ligase activity in the absence of sphingosine-1-phosphate. E3 ubiquitinligase activity is strongly activated by cytoplasmic sphingosine-1-phosphate Genatlas biochemistry entry for TRAF2:tumor necrosis factor (TNF)- receptor-associated factor,variably expressed in heart,liver,placenta,brain,skeletalmuscle,kidney,pancreas,intestinal epithelial cells,potentiial mediator of CD40 (TNFRSF5) and TNFR2 signaling,involvedin both IL1B and TNF/alpha signaling cascades,implicated in TNFR-mediated NF-kappa B activation in association withMAPK8
Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRAF2 (NM_021138) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF2 |
Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table
TRAF2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TRAF2:
Animal Models:
Mouse knock-outs for TRAF2: Traf2tm1.1Rbr Traf2tm1Mak
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Traf2):
TRAF2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRAF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/46 super-pathways (see all 46) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | BAFF in B-Cell Signaling | | | 3 | 4-1BB Pathway | | | 4 | Death Receptor Signalling | | | 5 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 EMD Millipore Pathways for TRAF2 (see all 9)
1  R&D Systems Pathway for TRAF2
5/36 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF2 (see all 36)
2 
Cell Signaling Technology (CST) Pathways for TRAF2
5/9  GeneGo (Thomson Reuters) Pathways for TRAF2 (see all 9)
5/15  BioSystems Pathways for TRAF2 (see all 15)
5/11 
Reactome Pathways for TRAF2 (see all 11)
5/9 
Kegg Pathways (Kegg details for TRAF2) (see all 9):
UniProtKB/Swiss-Prot: TRAF2_HUMAN, Q12933Pathway: Protein modification; protein ubiquitination
TRAF2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/436 Interacting proteins for TRAF2 (Q129331, 2, 3 ENSP000002476684) via UniProtKB, MINT, STRING, and/or I2D (see all 436)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TANK | Q928441, 2, 3, ENSP000002590754 | EBI-1046651,EBI-356349 MINT-47974 MINT-48259 I2D:
score=7 STRING: ENSP00000259075 | | TBK1 | Q9UHD22, 3, ENSP000003299674 | MINT-49272 MINT-48043 I2D:
score=6 STRING: ENSP00000329967 | | TAB1 | Q157502, 3, ENSP000002161604 | MINT-48027 MINT-49169 I2D:
score=4 STRING: ENSP00000216160 | | CALM2 | P621582, 3 | MINT-49550 I2D:
score=2 | | CALM3 | P621582, 3 | MINT-49550 I2D:
score=2 |
About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table
TRAF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRAF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRAF2 for compounds About GeneDecksing
 Browse Tocris compounds for TRAF2
10/19 Novoseek chemical compound relationships for TRAF2 gene (see all 19) About this table
Search CenterWatch for drugs/clinical trials and news about TRAF2
|
Transcripts
for TRAF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRAF2 gene: NM_021138.3 Unigene Cluster for TRAF2: TNF receptor-associated factor 2 Hs.522506 [show with all ESTs]Unigene Representative Sequence: BC06466211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000419057 ENST00000429509 ENST00000247668(uc010nbu.3 uc004cjv.3 uc011mek.2 uc010nbw.3)
ENST00000371645 ENST00000414589 ENST00000474950 ENST00000482854 ENST00000469701
ENST00000466107 ENST00000536468 ENST00000359662(uc010nbv.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRAF2 (NM_021138) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRAF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF2 |
Additional cDNA sequence: AK222961.1 AK289722.1 AK294607.1 AK298370.1 BC032410.1 BC033810.1 BC043492.1 BC064662.1 BX538160.1 HM991672.1 19 DOTS entries: DT.97845210 DT.101983141 DT.100822635 DT.100822631 DT.414361 DT.121167580 DT.95359979 DT.100822625 DT.100822626 DT.91655517 DT.91754463 DT.95168958 DT.121167548 DT.121167598 DT.40222126 DT.91754460 DT.97823964 DT.121167591 DT.40277325 24/185 AceView cDNA sequences (see all 185): CB139778 CR611225 AU131396 BU902770 BM827828 BM467693 BQ226491 BI767443 AU279730 BQ055676 BU857656 BM926917 BQ057635 CB106754 BQ065241 CB530012 BC064662 BQ186788 BP873536 BG392688 CB133303 BM785733 CB153051 NM_021138
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TRAF2 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRAF2
|
Expression
for TRAF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRAF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGGCAGAA
About this image
See TRAF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRAF2
SOURCE GeneReport for Unigene cluster: Hs.522506
SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF2 (see all 11):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRAF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRAF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRAF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF2 |
Orthologs
for TRAF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRAF2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRAF21 |
TNF receptor-associated factor 2 |
75.12(n)
79.44(a) |
|
417287 XM_415560.2 XP_415560.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TRAF26 |
-- |
58(a) |
1 ↔ 1 |
GL343888.1(8314-25243) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.104332 |
Xenopus laevis transcribed sequence with weak similarity more |
80.16(n) |
|
48045687 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1000054461 |
TNF receptor-associated factor 2-like |
65(n)
63.27(a) |
|
100005446 XM_001344465.3 XP_001344501.3 |
ENSEMBL Gene Tree for TRAF2 (if available)
TreeFam Gene Tree for TRAF2 (if available) |
Paralogs
for TRAF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRAF2 gene
- TRAF12 TRAF42 TRAF52 TRAF32 TRAF62
4 SIMAP similar genes for TRAF2 using alignment to 6 protein entries: TRAF2_HUMAN (see all proteins):TRAF1 TRAF3 TRAF5 TRAF6
TRAF2 for paralogs About GeneDecksing
|
Genomic Variants
for TRAF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRAF2 (139776364 - 139821067 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TRAF2
5 CNVs: 3785 9631 30350 5415 30359 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRAF2 |
|
Disorders
/ Diseases
for TRAF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRAF2 for disorders About GeneDecksing
OMIM gene information: 601895
OMIM disorders: --
20/49  diseases for TRAF2 (see all 49): About MalaCardsdiffuse large b-cell lymphoma patent ductus arteriosus lichen planus b-cell lymphomas
oral lichen planus malt lymphoma non-hodgkin lymphoma lupus erythematosus
splenomegaly ectodermal dysplasia systemic lupus erythematosus cylindromatosis
hodgkin's lymphoma macular degeneration chronic lymphocytic leukemia hepatitis c
lupus nephritis lymphocytic leukemia kaposi's sarcoma retinopathy of prematurity
10/19 Novoseek disease relationships for TRAF2 gene (see all 19) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
81.3 |
101 |
9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 77) |
| tumors |
68.7 |
97 |
9435232 (2), 12591926 (2), 9461607 (2), 12370254 (2) (see all 73) |
| malt lymphoma |
56.6 |
1 |
16512826 (1) |
| leukemia t-cell |
35 |
1 |
10385526 (1) |
| hodgkin disease |
33.6 |
2 |
11144929 (1), 19336568 (1) |
| inflammation |
27.4 |
1 |
17158355 (1) |
| lymphoma |
24.2 |
2 |
14713952 (1), 18981220 (1) |
| cancer |
5.61 |
9 |
19336568 (2), 18981220 (1), 18794145 (1) |
| lupus erythematosus systemic |
0 |
2 |
18269865 (1) |
| colon cancer |
0 |
3 |
19243468 (3) |
Human Genome Epidemiology (HuGE) Navigator: TRAF2 (24 documents)
Export disorders for TRAF2 gene to outside databases
|
Publications
for TRAF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRAF2 gene, integrated from 9 sources (see all 569):
(articles sorted by number of sources associating them with TRAF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. (PubMed id 7639698)1, 2, 3, 9 Song H.Y. and Donner D.B. (1995)
- Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)1, 2, 9 Zheng C....Wu H. (2010)
- TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. (PubMed id 18981220)1, 2, 9 Blackwell K....Habelhah H. (2009)
- PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. (PubMed id 19150425)1, 2, 9 Li S....Dorf M.E. (2009)
- Structural basis for the lack of E2 interaction in th e RING domain of TRAF2. (PubMed id 19810754)1, 2, 9 Yin Q....Wu H. (2009)
- TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. (PubMed id 11907583)1, 2, 9 Li X....Ashwell J.D. (2002)
- Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. (PubMed id 10346818)1, 2, 9 Baud V.... Karin M. (1999)
- ASK1 is essential for JNK/SAPK activation by TRAF2. (PubMed id 9774977)1, 2, 9 Nishitoh H.... Ichijo H. (1998)
- Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. (PubMed id 11784851)1, 2, 9 Chadee D.N.... Kyriakis J.M. (2002)
- A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PubMed id 8069916)1, 2, 9 Rothe M.... Goeddel D.V. (1994)
|
External Searches for TRAF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TRAF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRAF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRAF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRAF2 gene:
Search GeneIP for patents involving TRAF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRAF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for TRAF2 | | OriGene shRNA RFP for TRAF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRAF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRAF2 | | | OriGene Protein Over-expression Lysate for TRAF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRAF2 | | OriGene 3'-UTR Clone for TRAF2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRAF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRAF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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