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TRAF1 Gene

protein-coding   GIFtS: 67
GCID: GC09M123664

TNF Receptor-Associated Factor 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNF Receptor-Associated Factor 11 2
EBI62 3
MGC:103532
Epstein-Bar Virus-Induced Protein 62
Epstein-Barr Virus-Induced Protein 63

External Ids:    HGNC: 120311   Entrez Gene: 71852   Ensembl: ENSG000000565587   OMIM: 6017115   UniProtKB: Q130773   

Export aliases for TRAF1 gene to outside databases

Previous GC identifers: GC09M114770 GC09M115311 GC09M117118 GC09M119040 GC09M120744 GC09M122704 GC09M093282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRAF1 Gene:
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family.
TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily.
This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of
MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with
inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The
expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is
found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B
lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for TRAF1 Gene:
TRAF1 (TNF receptor-associated factor 1) is a protein-coding gene. Diseases associated with TRAF1 include alopecia areata, and mediastinitis. GO annotations related to this gene include thioesterase binding and ubiquitin protein ligase binding. An important paralog of this gene is TRAF4.

UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077
Function: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of
cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase
complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the
antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2

Gene Wiki entry for TRAF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRAF1 gene promoter:
         Elk-1   c-Rel   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRAF1 promoter sequence
   Search Chromatin IP Primers for TRAF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRAF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33-q34   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33-q34

TRAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123664:  view genomic region     (about GC identifiers)

Start:
123,664,671 bp from pter      End:
123,691,451 bp from pter
Size:
26,781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077 (See protein sequence)
Recommended Name: TNF receptor-associated factor 1  
Size: 416 amino acids; 46164 Da
Subunit: Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4,
TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA,
TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2.
Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed
by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14
Caution: Lacks a RING domain and has therefore no E3 ubiquitin-protein ligase activity by itself
Sequence caution: Sequence=BAC03449.1; Type=Frameshift; Positions=111;
1 PDB 3D structure from and Proteopedia for TRAF1:
3M0D (3D)    
Secondary accessions: B4DJ77 Q658U1 Q8NF13
Alternative splicing: 2 isoforms:  Q13077-1   Q13077-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF1: NX_Q13077

Explore proteomics data for TRAF1 at MOPED

Post-translational modifications: 

  • Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation1
  • Ubiquitination2 at Lys185, Lys193
  • Modification sites at PhosphoSitePlus

  • See TRAF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177874.1  NP_001177876.1  NP_005649.1  

    ENSEMBL proteins: 
     ENSP00000362994   ENSP00000443183   ENSP00000438583  

    TRAF1 Human Recombinant Protein Products:

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    Novus Biologicals TRAF1 Proteins
    Novus Biologicals TRAF1 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TRAF1
    Cloud-Clone Corp. Proteins for TRAF1

    TRAF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRAF1
    R&D Systems Antibodies for TRAF1 (TRAF-1)
    Cell Signaling Technology (CST) Antibodies for TRAF1 
    OriGene Antibodies for TRAF1
    OriGene Custom Antibody Services for TRAF1
    Novus Biologicals TRAF1 Antibodies
    Abcam antibodies for TRAF1
    Cloud-Clone Corp. Antibodies for TRAF1
    ThermoFisher Antibody for TRAF1
    LSBio Antibodies in human, mouse, rat for TRAF1

    TRAF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TRAF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRAF1
    Cloud-Clone Corp. CLIAs for TRAF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR027136 TRAF1
     IPR012227 TNF_rcpt--assoc_TRAF

    Graphical View of Domain Structure for InterPro Entry Q13077

    ProtoNet protein and cluster: Q13077

    2 Blocks protein domains:
    IPB002083 Meprin/TRAF-like MATH
    IPB002223 Pancreatic trypsin inhibitor (Kunitz)


    UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077
    Domain: The coiled coil domain mediates homo- and hetero-oligomerization
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of
    NF-kappa-B in response to TNF signaling
    Similarity: Contains 1 MATH domain


    TRAF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRAF1_HUMAN, Q13077
    Function: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of
    cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase
    complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the
    antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2

         Genatlas biochemistry entry for TRAF1:
    tumor necrosis factor (TNF)-receptor-associated factor 1,cytoplasmic,expressed in spleen,lung,testis,inducible
    molecule taking part in the signal transduction of TNFR2,LTBR,CD40,(TNFRSF5),CD30,LMP,and activating
    NFKB,involved in the blockage of apoptotic pathway,overexpressed in Hodgkin's disease and EBV + lymphoid cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11279055
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI11279055
    GO:0031996thioesterase binding IPI11279055
         
    TRAF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Traf1):
     cellular  hematopoietic system  immune system 

    TRAF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Traf1tm1Tsi for TRAF1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRAF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRAF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRAF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRAF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRAF1:
    hsa-mir-378a-3p (MIRT043860), hsa-mir-26b-5p (MIRT028837), hsa-mir-98-5p (MIRT027456)

    Block miRNA regulation of human, mouse, rat TRAF1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TRAF1:
    hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-516b hsa-miR-1299 hsa-miR-3612 hsa-miR-650 hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidTRAF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRAF1
    Predesigned siRNA for gene silencing in human, mouse, rat TRAF1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TRAF1

    Clone
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    OriGene clones in human, mouse for TRAF1 (see all 10)
    OriGene ORF clones in mouse, rat for TRAF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRAF1 (NM_005658)
    Sino Biological Human cDNA Clone for TRAF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRAF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRAF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRAF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8069916

    TRAF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRAF1 About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TWEAK Pathway0.87
    TRAIL Pathway0.40
    GITR Pathway0.46
    Fas Signaling0.35
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TWEAK Signaling Pathway0.31
    Apoptotic Pathways Triggered By HIV10.42
    2RANK Signaling in Osteoclasts
    RANK Pathway0.38
    RANKL/RANK Signaling Pathway0.31
    34-1BB Pathway
    4-1BB Pathway0.54
    NF-KappaB Activation by EBV0.42
    CD40 Signaling0.54
    TNFR2 Pathway0.37
    4TRAF Pathway
    TRAF Pathway0.42
    TNF Superfamily Pathway0.42
    5NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRAF1 (see all 13)
        TWEAK Pathway
    TRAF Pathway
    TNFR2 Pathway
    TRAIL Pathway
    Fas Signaling

    2 Cell Signaling Technology (CST) Pathways for TRAF1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    Selected BioSystems Pathways for TRAF1 (see all 8)
        Apoptosis
    EBV LMP1 signaling
    TNF-alpha/NF-kB Signaling Pathway
    TWEAK Signaling Pathway
    RANKL/RANK Signaling Pathway

    1 Sino Biological Pathway for TRAF1
        Death Receptor Signaling


    Selected Kegg Pathways  (Kegg details for TRAF1) (see all 8):
        NF-kappa B signaling pathway
    TNF signaling pathway
    Herpes simplex infection
    Epstein-Barr virus infection
    Pathways in cancer


    TRAF1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF1: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRAF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRAF1 (Q130771, 2, 3 ENSP000003629944) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49521 MINT-8415355 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49521 MINT-8415355 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49521 MINT-8415355 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49521 MINT-8415355 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49521 MINT-8415355 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS8069916
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0042981regulation of apoptotic process ----
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling RCA19641626

    TRAF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRAF1

    Selected Novoseek inferred chemical compound relationships for TRAF1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 57.6 4 17392826 (1), 19416236 (1)
    doxorubicin 30.3 2 12527335 (1), 15090542 (1)
    sb 203580 17 1 9759836 (1)
    paclitaxel 14.9 1 16080463 (1)
    rantes 11.9 2 14761676 (2)
    cycloheximide 10.5 1 11359904 (1)
    pd 98,059 9.47 2 14981539 (1)
    actinomycin d 6.07 1 14981539 (1)
    oligonucleotide 0 2 11978013 (1)
    zinc 0 2 8692885 (1), 15545599 (1)



    TRAF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRAF1 gene (3 alternative transcripts): 
    NM_001190945.1  NM_001190947.1  NM_005658.4  

    Unigene Cluster for TRAF1:

    TNF receptor-associated factor 1
    Hs.531251  [show with all ESTs]
    Unigene Representative Sequence: AL832989
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373887(uc004bku.2) ENST00000540010(uc010mvl.2) ENST00000546084(uc011lyg.2)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    7 qRT-PCR Assays for microRNAs that regulate TRAF1:
    hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-516b hsa-miR-1299 hsa-miR-3612 hsa-miR-650 hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmidTRAF1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): TRAF1 (NM_005658)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TRAF1
      QuantiFast Probe-based Assays in human, mouse, rat TRAF1

    Additional mRNA sequence: 

    AK090468.1 AK295959.1 AK315476.1 AL832989.1 BC024145.2 BT019408.1 U19261.1 

    5 DOTS entries:

    DT.312826  DT.100781898  DT.121205566  DT.75131157  DT.86856787 

    Selected AceView cDNA sequences (see all 106):

    AW262900 F09148 BM976805 NM_005658 BM722427 AI476301 AW953972 AA977631 
    AI554908 AW444488 AW771244 AW014547 CD370534 AW059923 BM470095 BC024145 
    CD369956 AI269033 CD365853 AL832989 AI378122 AA769375 AA922208 AA381677 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRAF1 expression in normal human tissues (normalized intensities)      TRAF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTGAAAC
    TRAF1 Expression
    About this image


    TRAF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 5 entries
             Inner Enamel Epithelial Cells Dental Enamel
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    TRAF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRAF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531251
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRAF1: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRAF1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRAF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRAF1
    QuantiTect SYBR Green Assays in human, mouse, rat TRAF1
    QuantiFast Probe-based Assays in human, mouse, rat TRAF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRAF1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Traf11 , 5 TNF receptor-associated factor 11, 5 85.62(n)1
    86.03(a)1
      2 (23.13 cM)5
    220291  NM_009421.31  NP_033447.21 
     349432565 
    chicken
    (Gallus gallus)
    Aves TRAF11 TNF receptor-associated factor 1 59.83(n)
    53.99(a)
      417123  XM_004945993.1  XP_004946050.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRAF16
    TNF receptor-associated factor 1
    51(a)
    1 ↔ 1
    AAWZ02038667(89-7557)
    zebrafish
    (Danio rerio)
    Actinopterygii traf11 TNF receptor-associated factor 1 55.62(n)
    47.28(a)
      100148503  NM_001128381.1  NP_001121853.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Traf-like6
    TNF-receptor-associated factor-like
    14(a)
    many ↔ many
    X(16309079-16311618)
    worm
    (Caenorhabditis elegans)
    Secernentea trf-16
    Protein TRF-1 (trf-1) mRNA, complete cds
    17(a)
    many ↔ many
    III(13430462-13433438) WBGene00006612


    ENSEMBL Gene Tree for TRAF1 (if available)
    TreeFam Gene Tree for TRAF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRAF1 gene
    TRAF42  TRAF52  TRAF22  TRAF32  TRAF62  
    3 SIMAP similar genes for TRAF1 using alignment to 1 protein entry:     TRAF1_HUMAN:
    TRAF3    TRAF2    TRAF5

    TRAF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRAF1 (see all 651)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862004041,2
    --93282233(+) AGGGCA/GGGGGG 3 -- ut310--------
    rs130531,2
    C,A,H--93282240(-) CCCCCA/CACCCC 3 -- ut31 ese3 trp32Minor allele frequency- C:0.25NA 4
    rs1407319441,2
    C--93288134(+) GTCTC-/TCTTCA
            
    TATAT
    3 -- int10--------
    rs113300361,2
    C--123664934(+) TTCCC-/TTTTCC 3 -- ut31 trp30--------
    rs793512841,2
    C--123668907(+) TTGTAA/GCAATT 3 -- int10--------
    rs625783791,2
    C--123669709(+) CCTTGT/AGCAGG 3 -- int12Minor allele frequency- A:0.09NA 122
    rs801740611,2
    C--123669857(+) ATTTTG/TCATTC 3 -- int10--------
    rs1114823861,2
    C,F--123674850(+) GAATCG/ACTTGA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs718454211,2
    C--123674950(+) AAGAA-/AAAGA 
            
    AAGAA
    3 -- int10--------
    rs1132466741,2
    C--123674954(+) GAAAGAAAGA/
            
    GAAAG
    3 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for TRAF1 (123664671 - 123691451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRAF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6700CNV Insertion18451855
    nsv893809CNV Gain21882294
    dgv2419e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRAF1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRAF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601711    OMIM disorders: --

    Selected diseases for TRAF1 (see all 52):    About MalaCards
    alopecia areata    mediastinitis    anaplastic large cell lymphoma    patent ductus arteriosus
    wegener's granulomatosis    alopecia    ectodermal dysplasia    hodgkin's lymphoma
    pemphigus    lupus nephritis    chronic lymphocytic leukemia    b-cell lymphomas
    b-cell chronic lymphocytic leukemia    diffuse large b-cell lymphoma    rheumatoid arthritis    nephritis
    systemic lupus erythematosus    glomerulonephritis    primary biliary cirrhosis    endometriosis

    1 disease from the University of Copenhagen DISEASES database for TRAF1:
    Rheumatoid arthritis

    TRAF1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TRAF1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.4 43 12709429 (2), 18759306 (1), 19076291 (1), 20302775 (1) (see all 34)
    hodgkin disease 54.3 17 15644776 (5), 20302775 (3), 19540595 (2), 11144929 (1) (see all 6)
    tumors 54.2 42 17392826 (3), 12709429 (2), 18759306 (1), 20302775 (1) (see all 33)
    anaplastic large cell lymphoma 53.5 3 15644776 (2), 12754742 (1)
    rheumatoid arthritis 51.9 7 18759306 (1), 18625278 (1), 18794853 (1), 19918040 (1) (see all 6)
    lymphoma 38.9 8 17405906 (2), 19540595 (2), 20302775 (1), 15644776 (1) (see all 5)
    lymphoproliferative disorders 38.1 1 19416236 (1)
    ebv infections 35.9 2 7859281 (1)
    lymphoma b-cell 29.9 4 17197926 (2), 15644776 (2)
    lymphoma non-hodgkins 27.4 1 11046039 (1)

    Genetic Association Database (GAD): TRAF1
    Human Genome Epidemiology (HuGE) Navigator: TRAF1 (58 documents)

    Export disorders for TRAF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRAF1 gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with TRAF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PubMed id 8069916)1, 2, 3, 9 Rothe M.... Goeddel D.V. (Cell 1994)
    2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)1, 2, 9 Zheng C.... Wu H. (Mol. Cell 2010)
    3. TNF receptor-associated factor 1 is a positive regulator of the NF- kappaB alternative pathway. (PubMed id 19698991)1, 2, 9 Lavorgna A.... Leonardi A. (Mol. Immunol. 2009)
    4. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. (PubMed id 18429822)1, 2, 9 Kato T. Jr.... Ono Y. (Genes Cells 2008)
    5. A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. (PubMed id 17880261)1, 4, 9 Kurreeman F.A....Toes R.E. (PLoS Med. 2007)
    6. Mass spectrometric analysis of tumor necrosis factor receptor- associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2. (PubMed id 15468071)1, 2, 9 Lee J.S.... Yoon J.B. (Proteomics 2004)
    7. Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (PubMed id 19336421)1, 4, 9 Nishimoto K....Momohara S. (Ann. Rheum. Dis. 2010)
    8. Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. (PubMed id 19287455)1, 2, 9 Wicovsky A....Wajant H. (Oncogene 2009)
    9. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. (PubMed id 10692572)1, 2, 9 Irmler M.... Tschopp J. (FEBS Lett. 2000)
    10. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PubMed id 9718306)1, 2, 9 Pullen S.S....Kehry M.R. (Biochemistry 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7185 HGNC: 12031 AceView: TRAF1 Ensembl:ENSG00000056558 euGenes: HUgn7185
    ECgene: TRAF1 Kegg: 7185 H-InvDB: TRAF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRAF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRAF1 gene:
    Search GeneIP for patents involving TRAF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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