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Aliases for TRAF1 Gene

Aliases for TRAF1 Gene

  • TNF Receptor Associated Factor 1 2 3 5
  • EBI6 3 4
  • Epstein-Barr Virus-Induced Protein 6 4
  • Epstein-Bar Virus-Induced Protein 6 3
  • MGC:10353 3

External Ids for TRAF1 Gene

Previous GeneCards Identifiers for TRAF1 Gene

  • GC09M114770
  • GC09M115311
  • GC09M117118
  • GC09M119040
  • GC09M120744
  • GC09M122704
  • GC09M123664
  • GC09M093282

Summaries for TRAF1 Gene

Entrez Gene Summary for TRAF1 Gene

  • The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for TRAF1 Gene

TRAF1 (TNF Receptor Associated Factor 1) is a Protein Coding gene. Diseases associated with TRAF1 include hodgkin lymphoma and rheumatoid arthritis. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include ubiquitin protein ligase binding and thioesterase binding. An important paralog of this gene is TRAF5.

UniProtKB/Swiss-Prot for TRAF1 Gene

  • Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Gene Wiki entry for TRAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAF1 Gene

Genomics for TRAF1 Gene

Regulatory Elements for TRAF1 Gene

Promoters for TRAF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAF1 Gene

Chromosome:
9
Start:
120,902,393 bp from pter
End:
120,929,173 bp from pter
Size:
26,781 bases
Orientation:
Minus strand

Genomic View for TRAF1 Gene

Genes around TRAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAF1 Gene

Proteins for TRAF1 Gene

  • Protein details for TRAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13077-TRAF1_HUMAN
    Recommended name:
    TNF receptor-associated factor 1
    Protein Accession:
    Q13077
    Secondary Accessions:
    • B4DJ77
    • Q658U1
    • Q8NF13

    Protein attributes for TRAF1 Gene

    Size:
    416 amino acids
    Molecular mass:
    46164 Da
    Quaternary structure:
    • Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP, TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14.
    SequenceCaution:
    • Sequence=BAC03449.1; Type=Frameshift; Positions=111; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAF1 Gene

    Alternative splice isoforms for TRAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRAF1 Gene

Proteomics data for TRAF1 Gene at MOPED

Post-translational modifications for TRAF1 Gene

  • Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
  • Ubiquitination at Lys 185 and Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRAF1 (TRAF1)

No data available for DME Specific Peptides for TRAF1 Gene

Domains & Families for TRAF1 Gene

Gene Families for TRAF1 Gene

Suggested Antigen Peptide Sequences for TRAF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13077

UniProtKB/Swiss-Prot:

TRAF1_HUMAN :
  • The coiled coil domain mediates homo- and hetero-oligomerization.
Domain:
  • The coiled coil domain mediates homo- and hetero-oligomerization.
  • The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
  • Contains 1 MATH domain.
genes like me logo Genes that share domains with TRAF1: view

Function for TRAF1 Gene

Molecular function for TRAF1 Gene

GENATLAS Biochemistry:
tumor necrosis factor (TNF)-receptor-associated factor 1,cytoplasmic,expressed in spleen,lung,testis,inducible molecule taking part in the signal transduction of TNFR2,LTBR,CD40,(TNFRSF5),CD30,LMP,and activating NFKB,involved in the blockage of apoptotic pathway,overexpressed in Hodgkins disease and EBV + lymphoid cells
UniProtKB/Swiss-Prot Function:
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

Gene Ontology (GO) - Molecular Function for TRAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 8069916
genes like me logo Genes that share ontologies with TRAF1: view
genes like me logo Genes that share phenotypes with TRAF1: view

Animal Models for TRAF1 Gene

MGI Knock Outs for TRAF1:

Animal Model Products

miRNA for TRAF1 Gene

miRTarBase miRNAs that target TRAF1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAF1 Gene

Localization for TRAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAF1 Gene COMPARTMENTS Subcellular localization image for TRAF1 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRAF1 Gene

Pathways & Interactions for TRAF1 Gene

genes like me logo Genes that share pathways with TRAF1: view

SIGNOR curated interactions for TRAF1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TRAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 10692572
GO:2001236 regulation of extrinsic apoptotic signaling pathway IDA 10692572
genes like me logo Genes that share ontologies with TRAF1: view

Drugs & Compounds for TRAF1 Gene

(9) Drugs for TRAF1 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 443
Etanercept Approved, Investigational Pharma 383
Infliximab Approved Pharma 349
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(7) Additional Compounds for TRAF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRAF1: view

Transcripts for TRAF1 Gene

Unigene Clusters for TRAF1 Gene

TNF receptor-associated factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAF1 Gene

No ASD Table

Relevant External Links for TRAF1 Gene

GeneLoc Exon Structure for
TRAF1
ECgene alternative splicing isoforms for
TRAF1

Expression for TRAF1 Gene

mRNA expression in normal human tissues for TRAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRAF1 Gene

This gene is overexpressed in Plasma (37.8), Lymph node (14.5), CD8 Tcells (7.0), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAF1 Gene



SOURCE GeneReport for Unigene cluster for TRAF1 Gene Hs.531251

genes like me logo Genes that share expression patterns with TRAF1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRAF1 Gene

Orthologs for TRAF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAF1 35
  • 99.44 (n)
  • 99.28 (a)
TRAF1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAF1 36
  • 88 (a)
OneToOne
TRAF1 35
  • 88.92 (n)
  • 88.43 (a)
dog
(Canis familiaris)
Mammalia TRAF1 35
  • 79.26 (n)
  • 77.97 (a)
TRAF1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Traf1 16
Traf1 35
  • 85.62 (n)
  • 86.03 (a)
Traf1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAF1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAF1 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Traf1 35
  • 85.05 (n)
  • 86.52 (a)
chicken
(Gallus gallus)
Aves TRAF1 35
  • 59.83 (n)
  • 53.99 (a)
TRAF1 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAF1 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii traf1 36
  • 36 (a)
OneToOne
traf1 35
  • 55.62 (n)
  • 47.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Traf-like 36
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea trf-1 36
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
ManyToMany
Species with no ortholog for TRAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRAF1 Gene

ENSEMBL:
Gene Tree for TRAF1 (if available)
TreeFam:
Gene Tree for TRAF1 (if available)

Paralogs for TRAF1 Gene

Paralogs for TRAF1 Gene

(3) SIMAP similar genes for TRAF1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAF1: view

Variants for TRAF1 Gene

Sequence variations from dbSNP and Humsavar for TRAF1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113495277 - 120,913,617(+) GGGCC(A/G)TGGGC reference, missense
rs758959 -- 120,914,421(+) GCACA(C/T)TGCTG intron-variant
rs1008382 -- 120,918,977(+) GACTT(C/G)CAGGA intron-variant
rs1008383 -- 120,921,301(+) GGGCT(C/G)GGATA intron-variant
rs1014529 -- 120,922,665(+) CAGGA(C/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAF1 Gene

Variant ID Type Subtype PubMed ID
nsv893809 CNV Gain 21882294
dgv2419e1 CNV Complex 17122850
nsv6700 CNV Insertion 18451855

Variation tolerance for TRAF1 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAF1 Gene

HapMap Linkage Disequilibrium report
TRAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAF1 Gene

Disorders for TRAF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRAF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hodgkin lymphoma
  • hodgkin's lymphoma
rheumatoid arthritis
  • rheumatoid arthritis, progression of
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TRAF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAF1

Genetic Association Database (GAD)
TRAF1
Human Genome Epidemiology (HuGE) Navigator
TRAF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAF1
genes like me logo Genes that share disorders with TRAF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAF1 Gene

Publications for TRAF1 Gene

  1. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PMID: 8069916) Rothe M. … Goeddel D.V. (Cell 1994) 2 3 4 23 67
  2. Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. (PMID: 19336421) Nishimoto K. … Momohara S. (Ann. Rheum. Dis. 2010) 3 23
  3. Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. (PMID: 19674979) Hinks A. … Thomson W. (Ann. Rheum. Dis. 2010) 3 23
  4. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PMID: 20385093) Zheng C. … Wu H. (Mol. Cell 2010) 3 23
  5. Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. (PMID: 19287455) Wicovsky A. … Wajant H. (Oncogene 2009) 3 23

Products for TRAF1 Gene

Sources for TRAF1 Gene

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