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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRAF1 Gene

protein-coding   GIFtS: 62
GCID: GC09M123664

TNF receptor-associated factor 1
 Explore 46 diseases affiliated with
TRAF1 via
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 Human Malady Compendium 
Biological research products
for TRAF1    

Aliases
for TRAF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TNF Receptor-Associated Factor 11 2
EBI61 2 3
MGC:103532
Epstein-Bar Virus-Induced Protein 62
Epstein-Barr Virus-Induced Protein 63

External Ids:    HGNC: 120311   Entrez Gene: 71852   Ensembl: ENSG000000565587   OMIM: 6017115   UniProtKB: Q130773   

Export aliases for TRAF1 gene to outside databases

Previous GC identifers: GC09M114770 GC09M115311 GC09M117118 GC09M119040 GC09M120744 GC09M122704 GC09M093282


Summaries
for TRAF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRAF1:
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This
protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and
NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins
(IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced
by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF
proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction
from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077
Function: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell
survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex
that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic
E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2

Gene Wiki entry for TRAF1


Genomic Views
for TRAF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRAF1 gene promoter:
         Elk-1   c-Rel   AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRAF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRAF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRAF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33-q34   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33-q34

TRAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRAF1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123664:  view genomic region     (about GC identifiers)

Start:
 123,664,671 bp from pter      End:
 123,691,451 bp from pter
Size:
 26,781 bases      Orientation:
 minus strand

Proteins
for TRAF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077 (See protein sequence)
Recommended Name: TNF receptor-associated factor 1  
Size: 416 amino acids; 46164 Da
Subunit: Homotrimer. Heterotrimer with TRAF2. Interacts with TNFRSF1A/TNFR1, TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40,
TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13C, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT,
XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus; a
single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2. Interacts with NFATC2IP,
TRAFD1 and with HIVEP3 (By similarity). Interacts with MAP3K14
Caution: Lacks a RING domain and has therefore no E3 ubiquitin-protein ligase activity by itself
Sequence caution: Sequence=BAC03449.1; Type=Frameshift; Positions=111;
1 PDB 3D structure from and Proteopedia for TRAF1:
3M0D (3D)    
Secondary accessions: B4DJ77 Q658U1 Q8NF13
Alternative splicing: 2 isoforms:  Q13077-1   Q13077-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRAF1: NX_Q13077

Post-translational modifications:

  • Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13077

    • TRAF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177874.1  NP_001177876.1  NP_005649.1  

    ENSEMBL proteins: 
     ENSP00000362994   ENSP00000443183   ENSP00000438583  

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    Novus Biologicals TRAF1 Proteins
    Novus Biologicals TRAF1 Lysates
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    ProSpec Recombinant Protein for TRAF1
    Uscn Proteins for TRAF1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8069916


    TRAF1 for ontologies           About GeneDecksing



    TRAF1 Antibody Products: 
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    Uscn ELISAs and CLIAs for TRAF1

    Protein Domains /
    Families
    for TRAF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRAF1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR027136 TRAF1
     IPR012227 TNF_rcpt--assoc_TRAF

    Graphical View of Domain Structure for InterPro Entry Q13077

    ProtoNet protein and cluster: Q13077

    2 Blocks protein families:
    IPB002083 Meprin/TRAF-like MATH
    IPB002223 Pancreatic trypsin inhibitor (Kunitz)


    UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077
    Domain: The coiled coil domain mediates homo- and hetero-oligomerization
    Domain: The MATH/TRAF domain binds to receptor cytoplasmic domains
    Domain: Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of
    NF-kappa-B in response to TNF signaling
    Similarity: Contains 1 MATH domain


    Function
    for TRAF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRAF1_HUMAN, Q13077
    Function: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell
    survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex
    that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic
    E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2

         Genatlas biochemistry entry for TRAF1:
    tumor necrosis factor (TNF)-receptor-associated factor 1,cytoplasmic,expressed in spleen,lung,testis,inducible molecule
    taking part in the signal transduction of TNFR2,LTBR,CD40,(TNFRSF5),CD30,LMP,and activating NFKB,involved in the
    blockage of apoptotic pathway,overexpressed in Hodgkin's disease and EBV + lymphoid cells

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TRAF1:
    hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-516b hsa-miR-1299 hsa-miR-3612 hsa-miR-650 hsa-miR-874
    SwitchGear 3'UTR luciferase reporter plasmid: TRAF1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRAF1 

    Cell Line
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    Search LifeMap BioReagents cell lines for TRAF1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRAF1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI11279055
    GO:0031996thioesterase binding IPI11279055


    TRAF1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Traf1tm1Tsi for TRAF1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Traf1):
     cellular  hematopoietic system  immune system 

    TRAF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRAF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TWEAK Pathway
    		TWEAK Pathway1.00
    		Apoptotic Pathways Triggered By HIV10.37
    		GITR Pathway0.46
    		TWEAK Signaling Pathway0.31
    		HIV-1 Nef- Negative effector of Fas and TNF-alpha0.42
    		Fas Signaling0.29
    		TRAIL Pathway0.40
    24-1BB Pathway
    		4-1BB Pathway1.00
    		NF-KappaB Activation by EBV0.31
    		CD40 Signaling0.54
    		TNFR2 Pathway0.29
    3TRAF Pathway
    		TRAF Pathway1.00
    		TNF Superfamily Pathway0.42
    4BAFF in B-Cell Signaling
    		RANK Pathway0.29
    		RANKL/RANK Signaling Pathway0.24
    5NF-kappaB Signaling
    		NF-kappaB Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRAF1 (see all 13)
        TWEAK Pathway
    TRAF Pathway
    TNFR2 Pathway
    TRAIL Pathway
    Fas Signaling

    2 Cell Signaling Technology (CST) Pathways for TRAF1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5/8 BioSystems Pathways for TRAF1 (see all 8) 
        Apoptosis
    EBV LMP1 signaling
    TNF-alpha/NF-kB Signaling Pathway
    RANKL/RANK Signaling Pathway
    TWEAK Signaling Pathway


    2         Kegg Pathways  (Kegg details for TRAF1):
        Pathways in cancer
    Small cell lung cancer


    TRAF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRAF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/177 Interacting proteins for TRAF1 (Q130771, 2, 3 ENSP000003629944) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRADDQ156282, 3, ENSP000003412684MINT-16893 I2D: score=5 STRING: ENSP00000341268
    RIPK2O433532, 3, ENSP000002207514MINT-15630 I2D: score=4 STRING: ENSP00000220751
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2863737 I2D: score=3 STRING: ENSP00000344782
    APIPQ96GX92, 3, ENSP000002783594MINT-49518 I2D: score=2 STRING: ENSP00000278359
    BAG2O958162, 3MINT-49500 MINT-8415355 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS8069916
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction IEA--
    GO:0042981regulation of apoptotic process IDA10692572
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascade RCA19641626


    TRAF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRAF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRAF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRAF1
    10/12 Novoseek chemical compound relationships for TRAF1 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    [alcl] 57.6 4 17392826 (1), 19416236 (1)
    doxorubicin 30.3 2 12527335 (1), 15090542 (1)
    sb 203580 17 1 9759836 (1)
    paclitaxel 14.9 1 16080463 (1)
    rantes 11.9 2 14761676 (2)
    cycloheximide 10.5 1 11359904 (1)
    pd 98,059 9.47 2 14981539 (1)
    actinomycin d 6.07 1 14981539 (1)
    oligonucleotide 0 2 11978013 (1)
    zinc 0 2 8692885 (1), 15545599 (1)

    Search CenterWatch for drugs/clinical trials and news about TRAF1 

    Transcripts
    for TRAF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRAF1 gene (3 alternative transcripts): 
    NM_001190945.1  NM_001190947.1  NM_005658.4  

    Unigene Cluster for TRAF1:

    TNF receptor-associated factor 1
    Hs.531251  [show with all ESTs]
    Unigene Representative Sequence: AL832989
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373887(uc004bku.2) ENST00000540010(uc010mvl.2) ENST00000546084(uc011lyg.2)


    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: TRAF1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK090468.1 AK295959.1 AK315476.1 AL832989.1 BC024145.2 BT019408.1 U19261.1 

    5 DOTS entries:

    DT.312826  DT.100781898  DT.121205566  DT.75131157  DT.86856787 

    24/106 AceView cDNA sequences (see all 106):

    AI269033 AW059923 BC024145 AI476301 AW771244 CD370534 AW014547 BM470095 
    AA977631 BM722427 CD369956 AW262900 NM_005658 AW953972 AW444488 AI554908 
    BM976805 F09148 BI522697 AA922208 AW044513 CD370023 AL832989 AA381677 

    GeneLoc Exon Structure


    Expression
    for TRAF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRAF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGTGAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TRAF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRAF1

    SOURCE GeneReport for Unigene cluster: Hs.531251
        SABiosciences Expression via Pathway-Focused PCR Arrays including TRAF1: 
              p53 Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for TRAF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TRAF1 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRAF11 TNF receptor-associated factor 1 60.55(n)
    55.07(a)    		   417123  XM_415406.3  XP_415406.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TRAF16
    --
    		 --
    		 53(a)
    42(a)
    		 1 ↔ 1
    possible ortholog
    		 AAWZ02038667(3524-7557)
    GL343570.1(380838-390805)
    zebrafish
    (Danio rerio)    		 Actinopterygii traf11 TNF receptor-associated factor 1 54.92(n)
    47.15(a)    		   100148503  NM_001128381.1  NP_001121853.1 


    ENSEMBL Gene Tree for TRAF1 (if available)
    TreeFam Gene Tree for TRAF1 (if available) 

    Paralogs
    for TRAF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRAF1 gene
    TRAF42  TRAF52  TRAF22  TRAF32  TRAF62  
    3 SIMAP similar genes for TRAF1 using alignment to 1 protein entry:     TRAF1_HUMAN:
    TRAF3    TRAF2    TRAF5

    TRAF1 for paralogs           About GeneDecksing



    Genomic Variants
    for TRAF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 NCBI SNPs in TRAF1 are shown (see all 527)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1113750891,2
    		C,--93281668(+) AGCTGG/AAACCT 3 -- ds50011Minor allele frequency- A:0.01NA 120
    rs735437801,2
    		C,F,--93282155(+) GAAATC/AATTCA 3 -- ut314Minor allele frequency- A:0.23WA CSA 124
    rs70371541,2
    		C,F,H,--93282741(+) GGCTTG/CTTCTA 3 -- ut315Minor allele frequency- C:0.03NS EA WA 536
    rs109850851,2
    		C,F,H,--93282747(+) TTCTAC/TAAATC 3 -- ut31 ese317Minor allele frequency- T:0.12NS EA NA WA CSA 1892
    rs1148718241,2
    		C,F,--93282917(+) TGCCAC/TGCTGT 3 -- ut311Minor allele frequency- T:0.05WA 118
    rs1150727251,2
    		C,F,--93282961(+) TGTTTG/ACTGCT 3 -- ut311Minor allele frequency- A:0.03WA 118
    rs412734021,2
    		C,--93282982(+) GACGAC/AACCAT 3 -- ut311Minor allele frequency- A:0.50NA 2
    rs109850861,2
    		C,F,H,--93283586(+) AGCCTC/TTGATG 3 -- ut31 ese34Minor allele frequency- T:0.01NS EA 416
    rs781846091,2
    		C,F,--93283817(+) AAGCAC/ACAAAG 3 -- ut311Minor allele frequency- A:0.05WA 118
    rs123799041,2
    		C,F,H,--93284304(+) CACCCG/AGTCCT 3 -- ut31 ese314Minor allele frequency- A:0.11NS EA NA WA CSA 1422

    HapMap Linkage Disequilibrium report for TRAF1 (123664671 - 123691451 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRAF1
         1 CNV: 3780

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TRAF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRAF1 for disorders           About GeneDecksing

    OMIM gene information: 601711    OMIM disorders: --

    20/46 diseases for TRAF1 (see all 46):    About MalaCards
    anaplastic large cell lymphoma    diffuse large b-cell lymphoma    patent ductus arteriosus    b-cell lymphomas
    non-hodgkin lymphoma    alopecia areata    wegener's granulomatosis    ectodermal dysplasia
    rheumatoid arthritis    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma
    chronic lymphocytic leukemia    lupus nephritis    alopecia    lymphocytic leukemia
    ulcerative colitis    insulin resistance    nephritis    renal cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for TRAF1:
    Rheumatoid arthritis

    10/17 Novoseek disease relationships for TRAF1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 71.4 43 12709429 (2), 18759306 (1), 19076291 (1), 20302775 (1) (see all 34)
    hodgkin disease 54.3 17 15644776 (5), 20302775 (3), 19540595 (2), 11144929 (1) (see all 6)
    tumors 54.2 42 17392826 (3), 12709429 (2), 18759306 (1), 20302775 (1) (see all 33)
    anaplastic large cell lymphoma 53.5 3 15644776 (2), 12754742 (1)
    rheumatoid arthritis 51.9 7 18759306 (1), 18625278 (1), 18794853 (1), 19918040 (1) (see all 6)
    lymphoma 38.9 8 17405906 (2), 19540595 (2), 20302775 (1), 15644776 (1) (see all 5)
    lymphoproliferative disorders 38.1 1 19416236 (1)
    ebv infections 35.9 2 7859281 (1)
    lymphoma b-cell 29.9 4 17197926 (2), 15644776 (2)
    lymphoma non-hodgkins 27.4 1 11046039 (1)

    Human Genome Epidemiology (HuGE) Navigator: TRAF1 (58 documents)

    Export disorders for TRAF1 gene to outside databases

    Publications
    for TRAF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRAF1 gene, integrated from 9 sources (see all 258):
    (articles sorted by number of sources associating them with TRAF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. (PubMed id 8069916)1, 2, 3, 9 Rothe M.... Goeddel D.V. (1994)
    2. Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation. (PubMed id 20385093)1, 2, 9 Zheng C....Wu H. (2010)
    3. TNF receptor-associated factor 1 is a positive regula tor of the NF-kappaB alternative pathway. (PubMed id 19698991)1, 2, 9 Lavorgna A....Leonardi A. (2009)
    4. Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. (PubMed id 18429822)1, 2, 9 Kato T....Ono Y. (2008)
    5. Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2. (PubMed id 15468071)1, 2, 9 Lee J.S....Yoon J.B. (2004)
    6. Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation. (PubMed id 19287455)1, 2, 9 Wicovsky A....Wajant H. (2009)
    7. Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. (PubMed id 10692572)1, 2, 9 Irmler M....Tschopp J. (2000)
    8. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. (PubMed id 9718306)1, 2, 9 Pullen S.S....Kehry M.R. (1998)
    9. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. (PubMed id 7859281)1, 2, 9 Mosialos G....Kieff E. (1995)
    10. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. (PubMed id 11907583)1, 2, 9 Li X....Ashwell J.D. (2002)

    External Searches for TRAF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing TRAF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7185 HGNC: 12031 AceView: TRAF1 Ensembl:ENSG00000056558 euGenes: HUgn7185
    ECgene: TRAF1 Kegg: 7185 H-InvDB: TRAF1

    Other Databases showing TRAF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRAF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRAF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRAF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TRAF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRAF1 gene:
    Search GeneIP for patents involving TRAF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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