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TRADD Gene

protein-coding   GIFtS: 65
GCID: GC16M067188

TNFRSF1A-Associated Via Death Domain

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TNFRSF1A-Associated Via Death Domain1 2 3
TNFR1-Associated DEATH Domain Protein2 3
Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein2
Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein2
Tumor Necrosis Factor Receptor-1-Associated Protein2

External Ids:    HGNC: 120301   Entrez Gene: 87172   Ensembl: ENSG000001028717   OMIM: 6035005   UniProtKB: Q156283   

Export aliases for TRADD gene to outside databases

Previous GC identifers: GC16M057882 GC16M067565 GC16M066923 GC16M066964 GC16M065745 GC16M053061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRADD Gene:
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1
and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2,
reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated
apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is
involved in the Fas-induced cell death pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRADD Gene:
TRADD (TNFRSF1A-associated via death domain) is a protein-coding gene. Diseases associated with TRADD include north american indian childhood cirrhosis, and patent ductus arteriosus. GO annotations related to this gene include kinase binding and identical protein binding.

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform
p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12
and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically
associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.
Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

Gene Wiki entry for TRADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRADD gene promoter:
         p53   AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRADD promoter sequence
   Search Chromatin IP Primers for TRADD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

TRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRADD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067188:  view genomic region     (about GC identifiers)

Start:
67,188,083 bp from pter      End:
67,194,201 bp from pter
Size:
6,119 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein  
Size: 312 amino acids; 34247 Da
Subunit: Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD,
HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP
Sequence caution: Sequence=AAA98482.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TRADD:
1F2H (3D)        1F3V (3D)    
Secondary accessions: B2RDS3 Q52NZ1

Explore the universe of human proteins at neXtProt for TRADD: NX_Q15628

Explore proteomics data for TRADD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRADD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003780.1  
    ENSEMBL proteins: 
     ENSP00000341268   ENSP00000462591  
    Reactome Protein details: Q15628

    TRADD Human Recombinant Protein Products:

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    Novus Biologicals TRADD Proteins
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    Cloud-Clone Corp. Proteins for TRADD

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    Cloud-Clone Corp. ELISAs for TRADD
    Cloud-Clone Corp. CLIAs for TRADD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009095 TRADD_N
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry Q15628

    ProtoNet protein and cluster: Q15628

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
    Domain: Requires the intact death domain to associate with TNFRSF1A/TNFR1
    Similarity: Contains 1 death domain


    TRADD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRADD_HUMAN, Q15628
    Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform
    p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12
    and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically
    associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.
    Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

         Genatlas biochemistry entry for TRADD:
    tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed
    cell death apoptosis and activating NF-Kappa B distinctly

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005164tumor necrosis factor receptor binding IEA--
    GO:0005515protein binding IPI1040062
    GO:0019900kinase binding IPI8612133
    GO:0032403protein complex binding IEA--
         
    TRADD for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tradd):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    TRADD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRADD: Traddtm1.1Mak Traddtm1.1Zgl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRADD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRADD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRADD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRADD

    miRNA
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    Block miRNA regulation of human, mouse, rat TRADD using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TRADD:
    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidTRADD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRADD

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TRADD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRADD (NM_003789)
    Sino Biological Human cDNA Clone for TRADD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRADD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRADD

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRADD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRADD_HUMAN, Q15628: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Note=Shuttles
    between the cytoplasm and the nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular2
    nucleus2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11684708
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0031264death-inducing signaling complex TAS18309324

    TRADD for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRADD About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptosis and survival TNFR1 signaling pathway0.52
    DR3 Signaling0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    3Apoptosis (KEGG)
    14-3-3 Induced Apoptosis0.37
    Apoptosis0.37
    4Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    Apoptosis Signaling Pathways0.35
    5Death Receptor Signalling
    Death Receptor Signalling0.71
    Regulation by c-FLIP0.00
    Dimerization of procaspase-80.71
    Caspase-8 activation0.00
    TNF signaling0.00
    Extrinsic Pathway for Apoptosis0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TRADD
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TRADD (see all 21)
        Caspase Cascade
    MAPK Signaling
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    TRAF Pathway

    1 Cell Signaling Technology (CST) Pathway for TRADD
        Apoptosis and Autophagy

    Selected GeneGo (Thomson Reuters) Pathways for TRADD (see all 8)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for TRADD (see all 11)
        Apoptosis
    EBV LMP1 signaling
    Apoptosis Modulation and Signaling
    p38 MAPK Signaling Pathway
    Integrated Breast Cancer Pathway

    2 Sino Biological Pathways for TRADD
        TNF Signaling
    Death Receptor Signaling

    4 Reactome Pathways for TRADD
        TNF signaling
    Caspase-8 activation
    Regulation by c-FLIP
    Dimerization of procaspase-8


    Selected Kegg Pathways  (Kegg details for TRADD) (see all 9):
        NF-kappa B signaling pathway
    Apoptosis
    RIG-I-like receptor signaling pathway
    TNF signaling pathway
    Adipocytokine signaling pathway


    TRADD for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRADD (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRADD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRADD (Q156281, 2, 3 ENSP000003412684) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1AP194381, 2, 3, ENSP000001627494EBI-359215,EBI-299451 MINT-14992 MINT-14991 MINT-14993 I2D: score=8 STRING: ENSP00000162749
    ENSG00000183311P074372, 3MINT-49485 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49485 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49485 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49485 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007165signal transduction TAS7758105
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors TAS8612133
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS8612133

    TRADD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRADD

    4 Novoseek inferred chemical compound relationships for TRADD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 74 2 17439942 (1), 17673602 (1)
    ceramide 32.9 3 12374208 (1), 10599977 (1), 10792026 (1)
    cysteine 2 2 9427646 (1), 10812970 (1)
    serine 0 1 15761471 (1)



    TRADD for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRADD gene (2 alternative transcripts): 
    NM_003789.3  NM_153425.1  

    Unigene Cluster for TRADD:

    TNFRSF1A-associated via death domain
    Hs.460996  [show with all ESTs]
    Unigene Representative Sequence: AK090673
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345057(uc002eri.1) ENST00000486556(uc002erh.1) ENST00000566247
    ENST00000563348(uc010vjb.1) ENST00000566104
    miRNA
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    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidTRADD 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TRADD

    Additional mRNA sequence: 

    AK090673.1 AK301593.1 AK315654.1 BC004491.2 BT006934.1 L41690.1 

    6 DOTS entries:

    DT.86852420  DT.100023011  DT.100754374  DT.91786845  DT.75103386  DT.91983549 

    Selected AceView cDNA sequences (see all 138):

    AA748993 AW299865 AA835677 NM_153425 BM473554 AW293156 BI821617 BE326626 
    BF062050 AI344303 AA916906 BQ707739 L41690 BE563501 BE464241 CB054809 
    CF127053 AA954084 BT006934 CK819365 AA741438 AI131201 BE272574 BU731612 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRADD    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                    -           -     -                     
    SP2:                    -           -                           
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for TRADD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRADD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACCTTG
    TRADD Expression
    About this image


    TRADD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TRADD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRADD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460996

    UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
    Tissue specificity: Found in all examined tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRADD (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TRADD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRADD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRADD gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tradd1 , 5 TNFRSF1A-associated via death domain1, 5 80.11(n)1
    77.1(a)1
      8 (53.04 cM)5
    716091  NM_001033161.21  NP_001028333.11 
     1052582865 
    chicken
    (Gallus gallus)
    Aves TRADD1 TNFRSF1A-associated via death domain 57.67(n)
    52.25(a)
      415700  XM_004944139.1  XP_004944196.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRADD6
    TNFRSF1A-associated via death domain
    52(a)
    1 ↔ 1
    5(108485662-108495806)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tradd1 TNFRSF1A-associated via death domain 48.78(n)
    45.33(a)
      100494283  XM_004913534.1  XP_004913591.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tradd1 tnfrsf1a-associated via death domain 49.81(n)
    47.57(a)
      58130  NM_131607.2  NP_571682.1 


    ENSEMBL Gene Tree for TRADD (if available)
    TreeFam Gene Tree for TRADD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRADD (see all 82)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3773067911,2
    C--67187590(+) AAAAA-/TTA   
       AAATT
    AAAAA
    1 -- ds50010--------
    rs1901518101,2
    --67187678(+) AAAAAC/TCCACA 1 -- ds50010--------
    rs129181211,2
    C,F,H--67187795(+) CTGTCC/TCCTGC 1 -- ds50019Minor allele frequency- T:0.04NS NA 1356
    rs133349451,2
    H--67187874(+) tttgaG/Aacagg 1 -- ds50011Minor allele frequency- A:0.00NS 120
    rs133127291,2
    C,F--67187947(-) GAGCAT/CGGAAG 1 -- ds50012Minor allele frequency- C:0.04NS 78
    rs1478463321,2
    C--67188140(+) TTCGGG/TGTCCC 1 -- ut310--------
    rs133127281,2
    C,F--67188189(-) GAAGTA/TAAACA 1 -- ut3110Minor allele frequency- T:0.06NS CSA WA 846
    rs1920395061,2
    --67188278(+) TGGCTA/GTAAGC 1 -- ut310--------
    rs1413640391,2
    --67188285(+) AAGCCC/GCGCTT 1 -- ut310--------
    rs1435364771,2
    C--67188353(+) TATCAA/CAGTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRADD (67188083 - 67194201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TRADD:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2887n71CNV Loss21882294
    dgv2888n71CNV Loss21882294
    nsv906794CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv827707CNV Loss20364138
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Human Gene Mutation Database (HGMD): TRADD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRADD
    DNA2.0 Custom Variant and Variant Library Synthesis for TRADD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603500    OMIM disorders: --

    Selected diseases for TRADD (see all 45):    
    About MalaCards
    north american indian childhood cirrhosis    patent ductus arteriosus    epidermolysis bullosa simplex    burkitt's lymphoma
    ankylosing spondylitis    epidermolysis bullosa    ectodermal dysplasia    keloids
    spondylitis    lupus nephritis    diphtheria    hepatitis c virus
    nephritis    lymphoblastic leukemia    hepatitis c    hodgkin's lymphoma
    non-hodgkin lymphoma    colon adenocarcinoma    systemic lupus erythematosus    myelodysplastic syndromes


    TRADD for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for TRADD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.4 48 8245538 (2), 16611992 (2), 1910814 (1), 1922108 (1) (see all 41)
    tumors 60.5 45 8245538 (2), 18713013 (2), 16940186 (2), 1910814 (1) (see all 40)
    burkitt lymphoma 17.2 1 10409763 (1)
    inflammation 15.8 1 16470584 (1)
    cancer 6.93 1 19904742 (1)
    lymphoblastic leukemia acute 0 1 17378240 (1)
    breast cancer 0 2 12604596 (2)
    metastasis 0 1 15991280 (1)
    hepatitis c 0 1 11336543 (1)
    melanoma 0 1 8144583 (1)

    Genetic Association Database (GAD): TRADD
    Human Genome Epidemiology (HuGE) Navigator: TRADD (10 documents)

    Export disorders for TRADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRADD gene, integrated from 10 sources (see all 217):
    (articles sorted by number of sources associating them with TRADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PubMed id 7758105)1, 2, 3, 9 Hsu H.... Goeddel D.V. (Cell 1995)
    2. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)1, 2, 9 Inada H.... Inagaki M. (J. Cell Biol. 2001)
    3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (Rheumatology (Oxford) 2008)
    4. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 9 Zhang H.... Min W. (J. Biol. Chem. 2004)
    5. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)1, 2, 9 Hsu H.... Goeddel D.V. (Immunity 1996)
    6. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PubMed id 18990758)1, 4, 9 Cerhan J.R....Slager S.L. (amp 2008)
    7. Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese. (PubMed id 21068102)1, 4 Davidson S.I....Xu H. (Ann. Rheum. Dis. 2011)
    8. The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD). (PubMed id 19854717)1, 4 Pointon J.J....Wordsworth B.P. (Ann. Rheum. Dis. 2010)
    9. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    10. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8717 HGNC: 12030 AceView: TRADD Ensembl:ENSG00000102871 euGenes: HUgn8717
    ECgene: TRADD Kegg: 8717 H-InvDB: TRADD

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRADD Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tradd/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRADD gene:
    Search GeneIP for patents involving TRADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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