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Aliases for TRADD Gene

Aliases for TRADD Gene

  • TNFRSF1A-Associated Via Death Domain 2 3 4
  • Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein 3
  • Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein 3
  • Tumor Necrosis Factor Receptor-1-Associated Protein 3
  • TNFR1-Associated Death Domain Protein 3
  • TNFR1-Associated DEATH Domain Protein 4
  • Hs.89862 3

External Ids for TRADD Gene

Previous GeneCards Identifiers for TRADD Gene

  • GC16M057882
  • GC16M067565
  • GC16M066923
  • GC16M066964
  • GC16M065745
  • GC16M067188
  • GC16M053061

Summaries for TRADD Gene

Entrez Gene Summary for TRADD Gene

  • The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRADD Gene

TRADD (TNFRSF1A-Associated Via Death Domain) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include identical protein binding and kinase binding.

UniProtKB/Swiss-Prot for TRADD Gene

  • The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Gene Wiki entry for TRADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRADD Gene

Genomics for TRADD Gene

Regulatory Elements for TRADD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRADD Gene

Start:
67,154,180 bp from pter
End:
67,160,298 bp from pter
Size:
6,119 bases
Orientation:
Minus strand

Genomic View for TRADD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRADD Gene

Proteins for TRADD Gene

  • Protein details for TRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15628-TRADD_HUMAN
    Recommended name:
    Tumor necrosis factor receptor type 1-associated DEATH domain protein
    Protein Accession:
    Q15628
    Secondary Accessions:
    • B2RDS3
    • B3KQZ9
    • Q52NZ1

    Protein attributes for TRADD Gene

    Size:
    312 amino acids
    Molecular mass:
    34247 Da
    Quaternary structure:
    • Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
    SequenceCaution:
    • Sequence=AAA98482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRADD Gene

    Alternative splice isoforms for TRADD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRADD Gene

Proteomics data for TRADD Gene at MOPED

Post-translational modifications for TRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRADD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRADD (TRADD)

No data available for DME Specific Peptides for TRADD Gene

Domains for TRADD Gene

Protein Domains for TRADD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRADD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15628

UniProtKB/Swiss-Prot:

TRADD_HUMAN :
  • Q15628
Domain:
  • Requires the intact death domain to associate with TNFRSF1A/TNFR1
  • Contains 1 death domain.
genes like me logo Genes that share domains with TRADD: view

No data available for Gene Families for TRADD Gene

Function for TRADD Gene

Molecular function for TRADD Gene

GENATLAS Biochemistry: tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed cell death apoptosis and activating NF-Kappa B distinctly
UniProtKB/Swiss-Prot Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 1040062
GO:0019900 kinase binding IPI 8612133
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TRADD: view
genes like me logo Genes that share phenotypes with TRADD: view

Animal Models for TRADD Gene

MGI Knock Outs for TRADD:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRADD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRADD Gene

Localization for TRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRADD Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRADD Gene COMPARTMENTS Subcellular localization image for TRADD gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 2
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 11684708
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0031264 death-inducing signaling complex TAS 18309324
genes like me logo Genes that share ontologies with TRADD: view

Pathways for TRADD Gene

genes like me logo Genes that share pathways with TRADD: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction TAS 7758105
GO:0007166 cell surface receptor signaling pathway TAS --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS 8612133
genes like me logo Genes that share ontologies with TRADD: view

Compounds for TRADD Gene

(4) Novoseek inferred chemical compound relationships for TRADD Gene

Compound -log(P) Hits PubMed IDs
tab-1 74 2
ceramide 32.9 3
cysteine 2 2
serine 0 1
genes like me logo Genes that share compounds with TRADD: view

Transcripts for TRADD Gene

Unigene Clusters for TRADD Gene

TNFRSF1A-associated via death domain:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRADD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRADD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TRADD Gene

GeneLoc Exon Structure for
TRADD
ECgene alternative splicing isoforms for
TRADD

Expression for TRADD Gene

mRNA expression in normal human tissues for TRADD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRADD Gene

SOURCE GeneReport for Unigene cluster for TRADD Gene Hs.460996

mRNA Expression by UniProt/SwissProt for TRADD Gene

Q15628-TRADD_HUMAN
Tissue specificity: Found in all examined tissues
genes like me logo Genes that share expressions with TRADD: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRADD Gene

Orthologs for TRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRADD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRADD 35
  • 99.68 (n)
  • 99.35 (a)
TRADD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRADD 35
  • 84.99 (n)
  • 82.64 (a)
TRADD 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRADD 35
  • 86.86 (n)
  • 86.22 (a)
TRADD 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tradd 35
  • 80.11 (n)
  • 77.1 (a)
Tradd 16
Tradd 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRADD 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tradd 35
  • 79.78 (n)
  • 77.42 (a)
chicken
(Gallus gallus)
Aves TRADD 35
  • 57.67 (n)
  • 52.25 (a)
TRADD 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRADD 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tradd 35
  • 48.78 (n)
  • 45.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tradd 35
  • 49.81 (n)
  • 47.57 (a)
tradd 36
  • 42 (a)
OneToOne
Species with no ortholog for TRADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRADD Gene

ENSEMBL:
Gene Tree for TRADD (if available)
TreeFam:
Gene Tree for TRADD (if available)

Paralogs for TRADD Gene

No data available for Paralogs for TRADD Gene

Variants for TRADD Gene

Sequence variations from dbSNP and Humsavar for TRADD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3136637 -- 67,156,074(-) CGAGA(C/G)CCCCT intron-variant, utr-variant-5-prime
rs3834550 -- 67,157,590(-) tcagg(-/G)acggc intron-variant
rs8060496 -- 67,157,812(+) CAGCC(A/G)AGGAA intron-variant
rs11282585 -- 67,157,987(+) TACTC(-/TCCAG)TCATC intron-variant
rs11574518 -- 67,155,583(-) TGCAG(C/T)TGCGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRADD Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680

Relevant External Links for TRADD Gene

HapMap Linkage Disequilibrium report
TRADD
Human Gene Mutation Database (HGMD)
TRADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRADD Gene

Disorders for TRADD Gene

(10) Novoseek inferred disease relationships for TRADD Gene

Disease -log(P) Hits PubMed IDs
necrosis 74.4 43
tumors 60.5 43
burkitt lymphoma 17.2 1
inflammation 15.8 1
cancer 6.93 1

Relevant External Links for TRADD

Genetic Association Database (GAD)
TRADD
Human Genome Epidemiology (HuGE) Navigator
TRADD
genes like me logo Genes that share disorders with TRADD: view

No data available for UniProtKB/Swiss-Prot for TRADD Gene

Publications for TRADD Gene

  1. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PMID: 7758105) Hsu H. … Goeddel D.V. (Cell 1995) 2 3 4 23
  2. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PMID: 8612133) Hsu H. … Goeddel D.V. (Immunity 1996) 3 4 23
  3. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PMID: 11684708) Inada H. … Inagaki M. (J. Cell Biol. 2001) 3 4 23
  4. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PMID: 15310755) Zhang H. … Min W. (J. Biol. Chem. 2004) 3 4 23
  5. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PMID: 18990758) Cerhan J.R. … Slager S.L. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 23 48

Products for TRADD Gene

Sources for TRADD Gene

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