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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRADD Gene

protein-coding GIFtS: 64
GCID: GC16M067188

TNFRSF1A-associated via death domain

Explore 43 diseases affiliated with
TRADD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TNFRSF1A-Associated Via Death Domain¹ ² ³
TNFR1-Associated DEATH Domain Protein² ³
Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein²
Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein²
Tumor Necrosis Factor Receptor-1-Associated Protein²

External Ids:	HGNC: 12030¹	Entrez Gene: 8717²	Ensembl: ENSG00000102871⁷	OMIM: 603500⁵	UniProtKB: Q15628³

Export aliases for TRADD gene to outside databases

Previous GC identifers: GC16M057882 GC16M067565 GC16M066923 GC16M066964 GC16M065745 GC16M053061

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRADD:

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and

mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces

the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This

protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced

cell death pathway. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628

Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform

p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and

isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with

the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads

to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

Gene Wiki entry for TRADD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRADD gene promoter:
p53 AP-1 ATF-2 MyoD c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRADD promoter sequence

Search SABiosciences Chromatin IP Primers for TRADD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRADD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22

TRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRADD gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M067188: view genomic region (about GC identifiers)

Start:	67,188,083 bp from pter	End:	67,194,201 bp from pter
Size:	6,119 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein

Size: 312 amino acids; 34247 Da

Subunit: Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2,

KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP

Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Note=Shuttles

between the cytoplasm and the nucleus (By similarity)

Sequence caution: Sequence=AAA98482.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for TRADD:

1F2H (3D)

1F3V (3D)

Secondary accessions: B2RDS3 Q52NZ1

Explore the universe of human proteins at neXtProt for TRADD: NX_Q15628

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15628

TRADD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003780.1

ENSEMBL proteins:

ENSP00000341268 ENSP00000462591

Reactome Protein details: Q15628
Human Recombinant Protein Products for TRADD:

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	Novus Biologicals TRADD Proteins Novus Biologicals TRADD Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRADD

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	11684708
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0043235	receptor complex	IDA	8612133

TRADD for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TRADD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRADD for domains About GeneDecksing

3 InterPro domains/families:

IPR009095 TRADD_N

IPR011029 DEATH-like_dom

IPR000488 Death_domain

Graphical View of Domain Structure for InterPro Entry Q15628

ProtoNet protein and cluster: Q15628

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628

Domain: Requires the intact death domain to associate with TNFRSF1A/TNFR1

Similarity: Contains 1 death domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRADD_HUMAN, Q15628

Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform

p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and

isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with

the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads

to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

Genatlas biochemistry entry for TRADD:

tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed cell

death apoptosis and activating NF-Kappa B distinctly

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IPI	19781631
GO:0019900	kinase binding	IPI	8612133
GO:0042802	identical protein binding	IPI	11684708
GO:0060090	binding, bridging	IPI	8612133

TRADD for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tradd):

cellular

hematopoietic system

homeostasis/metabolism

immune system

no phenotypic analysis

TRADD for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for TRADD: Tradd^tm1.1Mak Tradd^tm1.1Zgl

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRADD

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate TRADD:
		hsa-miR-324-3p
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		Sirion Biotech Custom design and validation of potent shRNA sequences against TRADD

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRADD
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRADD

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

8/9 pathways (see all 9)
TWEAK Pathway	1.00	Apoptosis and survival TNFR1 signaling pathway	0.40
DR3 Signaling	0.87	TNF Signaling	0.40
TNFR1 Pathway	0.53	Apoptotic Pathways Triggered By HIV1	0.37
HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	Apoptosis through Death Receptors	0.32

Death Receptor Signalling

Death Receptor Signalling	1.00	Caspase-8 activation	0.75
Extrinsic Pathway for Apoptosis	1.00	TNF signaling	0.58
Dimerization of procaspase-8	0.75

Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46
	Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway	1.00			Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway	0.46

Apoptosis and survival_Caspase cascade

	Apoptosis and survival_Caspase cascade	1.00			Caspase cascade in apoptosis	0.42
	Apoptosis and survival Caspase cascade	1.00

Apoptosis and survival_Apoptotic TNF-family pathways

	Apoptosis and survival Apoptotic TNF-family pathways	1.00			Apoptosis Signaling Pathways	0.35
	Apoptosis and survival_Apoptotic TNF-family pathways	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for TRADD (see all 8)

	Transcription NF-kB signaling pathway
	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Caspase cascade
	Immune response IL-9 signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

1 R&D Systems Pathway for TRADD

Apoptosis Signaling Pathways

5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRADD (see all 21)

	Caspase Cascade
	MAPK Signaling
	TWEAK Pathway
	14-3-3 Induced Apoptosis
	TRAF Pathway

1 Cell Signaling Technology (CST) Pathway for TRADD

Apoptosis and Autophagy

5/8 GeneGo (Thomson Reuters) Pathways for TRADD (see all 8)

	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
	Apoptosis and survival Caspase cascade
	Immune response IL-9 signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
	Apoptosis and survival TNFR1 signaling pathway

5/11 BioSystems Pathways for TRADD (see all 11)

	Apoptosis
	EBV LMP1 signaling
	Integrated Breast Cancer Pathway
	p38 MAPK Signaling Pathway
	Apoptosis Modulation and Signaling

5/6 Reactome Pathways for TRADD (see all 6)

	Death Receptor Signalling
	TNF signaling
	Extrinsic Pathway for Apoptosis
	Caspase-8 activation
	Dimerization of procaspase-8

5 Kegg Pathways (Kegg details for TRADD):

	Apoptosis
	RIG-I-like receptor signaling pathway
	Adipocytokine signaling pathway
	Tuberculosis
	Hepatitis C

TRADD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRADD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/128 Interacting proteins for TRADD (Q15628^{1, 2, 3} ENSP00000341268⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 128)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM2	P62158²^,³	MINT-49484 I2D: score=2
CALM3	P62158²^,³	MINT-49484 I2D: score=2
KRT18	P05783¹^,³, ENSP00000373487⁴	EBI-359215,EBI-297888 I2D: score=4 STRING: ENSP00000373487
AIFM1	O95831²^,³, ENSP00000287295⁴	MINT-49463 I2D: score=2 STRING: ENSP00000287295
KIAA1967	Q8N163²^,³, ENSP00000310670⁴	MINT-49487 I2D: score=2 STRING: ENSP00000310670

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0006917	induction of apoptosis	IDA	8612133
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS	--
GO:0007165	signal transduction	TAS	7758105
GO:0008633	activation of pro-apoptotic gene products	--	--

TRADD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRADD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRADD
4 Novoseek chemical compound relationships for TRADD gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tab-1	74	2	17439942 (1), 17673602 (1)
ceramide	32.9	3	12374208 (1), 10599977 (1), 10792026 (1)
cysteine	2	2	9427646 (1), 10812970 (1)
serine	0	1	15761471 (1)

Search CenterWatch for drugs/clinical trials and news about TRADD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRADD gene (2 alternative transcripts):

NM_003789.3 NM_153425.1

Unigene Cluster for TRADD:

TNFRSF1A-associated via death domain

Hs.460996 [show with all ESTs]

Unigene Representative Sequence: AK090673

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000345057(uc002eri.1) ENST00000486556(uc002erh.1) ENST00000566247

ENST00000563348(uc010vjb.1) ENST00000566104

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		hsa-miR-324-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TRADD 3' UTR sequence

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Additional cDNA sequence:

AK090673.1 AK301593.1 AK315654.1 BC004491.2 BT006934.1 L41690.1

6 DOTS entries:

DT.86852420 DT.100023011 DT.100754374 DT.91786845 DT.75103386 DT.91983549

24/138 AceView cDNA sequences (see all 138):

BQ707739 CA426418 BQ709164 AW299865 BT006934 AI633660 BE795807 BE272574

BE326626 AA835677 AW293156 BF222501 NM_003789 CK819365 AI131201 AI344303

CF127053 AI720989 BG431162 AW138709 BE464241 AA741438 BF062050 BU731612

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TRADD About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:							-				-		-
SP2:							-				-
SP3:											-		-
SP4:

ECgene alternative splicing isoforms for TRADD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRADD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCACCTTG

About this image

TRADD expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRADD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRADD

SOURCE GeneReport for Unigene cluster: Hs.460996

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628

Tissue specificity: Found in all examined tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including TRADD (see all 7):

Antiviral Response in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

TNF Ligands & Receptors in human mouse rat

NFKB Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRADD

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRADD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRADD gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tradd^{1 , 5}	TNFRSF1A-associated via death domain^{1, 5}	80.11(n)¹ 77.1(a)¹		8 (53.04 cM)⁵ 71609¹ NM_001033161.2¹ NP_001028333.1¹ 105258286⁵
chicken (Gallus gallus)	Aves	TRADD¹	TNFRSF1A-associated via death domain	57.55(n) 52.25(a)		415700 XM_414067.3 XP_414067.3
lizard (Anolis carolinensis)	Reptilia	TRADD⁶	--	55(a)	1 ↔ 1	5(108487405-108495800)
zebrafish (Danio rerio)	Actinopterygii	tradd¹	tnfrsf1a-associated via death domain	49.19(n) 47.19(a)		58130 NM_131607.2 NP_571682.1

ENSEMBL Gene Tree for TRADD (if available)
TreeFam Gene Tree for TRADD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190151810^1,2		--	67187678(+)	`AAAAAC/TCCACA`	1	--	ds500¹		0	--	--	--	--
rs12918121^1,2	C,F,H	--	67187795(+)	`CTGTCC/TCCTGC`	1	--	ds500¹		9		NS NA	1356
rs13334945^1,2	H	--	67187874(+)	`tttgaG/Aacagg`	1	--	ds500¹		1		NS	120
rs13312729^1,2	C,F	--	67187947(-)	`GAGCAT/CGGAAG`	1	--	ds500¹		2		NS	78
rs147846332^1,2		--	67188140(+)	`TTCGGG/TGTCCC`	1	--	ut3¹		0	--	--	--	--
rs13312728^1,2	C,F	--	67188189(-)	`GAAGTA/TAAACA`	1	--	ut3¹		10		NS CSA WA	846
rs192039506^1,2		--	67188278(+)	`TGGCTA/GTAAGC`	1	--	ut3¹		0	--	--	--	--
rs141364039^1,2		--	67188285(+)	`AAGCCC/GCGCTT`	1	--	ut3¹		0	--	--	--	--
rs143536477^1,2		--	67188353(+)	`TATCAA/CAGTAC`	1	--	ut3¹		0	--	--	--	--
rs56176824^1,2	C	--	67188375(+)	`TCCCCA/TATGAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRADD (67188083 - 67194201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRADD: --
Human Gene Mutation Database (HGMD): TRADD

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRADD for disorders           About GeneDecksing

OMIM gene information: 603500    OMIM disorders: --

20/43 diseases for TRADD (see all 43):    About MalaCards

north american indian childhood cirrhosis epidermolysis bullosa patent ductus arteriosus epidermolysis bullosa simplex

non-hodgkin lymphoma burkitt's lymphoma ankylosing spondylitis lymphoblastic leukemia

systemic lupus erythematosus lupus erythematosus hodgkin's lymphoma acute lymphoblastic leukemia

chronic lymphocytic leukemia hepatitis c lupus nephritis lymphocytic leukemia

spondylitis nephritis diphtheria multiple myeloma

10 Novoseek disease relationships for TRADD gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	74.4	48	8245538 (2), 16611992 (2), 1910814 (1), 1922108 (1) (see all 41)
tumors	60.5	45	8245538 (2), 18713013 (2), 16940186 (2), 1910814 (1) (see all 40)
burkitt lymphoma	17.2	1	10409763 (1)
inflammation	15.8	1	16470584 (1)
cancer	6.93	1	19904742 (1)
lymphoblastic leukemia acute	0	1	17378240 (1)
breast cancer	0	2	12604596 (2)
metastasis	0	1	15991280 (1)
hepatitis c	0	1	11336543 (1)
melanoma	0	1	8144583 (1)

Human Genome Epidemiology (HuGE) Navigator: TRADD (10 documents)

Export disorders for TRADD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRADD gene, integrated from 9 sources (see all 210):
(articles sorted by number of sources associating them with TRADD)

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PubMed id 7758105)^{1, 2, 3, 9} Hsu H.... Goeddel D.V. (1995)
Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)^{1, 2, 9} Inada H.... Inagaki M. (2001)
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)^{1, 2, 9} Zhang H.... Min W. (2004)
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)^{1, 2, 9} Hsu H.... Goeddel D.V. (1996)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells. (PubMed id 11032752)^{1, 2} Li X.... Hug H. (2000)
A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. (PubMed id 10892748)^{1, 2} Park Y.C.... Wu H. (2000)
Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. (PubMed id 10911999)^{1, 2} Tsao D.H....Lin L.L. (2000)
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)^{1, 2} Sanz L.... Moscat J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8717	HGNC: 12030	AceView: TRADD	Ensembl:ENSG00000102871	euGenes: HUgn8717
ECgene: TRADD	Kegg: 8717	H-InvDB: TRADD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRADD	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TRADD	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/tradd/

Intellectual Property for TRADD gene
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Patent Information for TRADD gene:
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TNFRSF1A-associated via death domain

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