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Aliases for TRADD Gene

Aliases for TRADD Gene

  • TNFRSF1A Associated Via Death Domain 2 3
  • TNFRSF1A-Associated Via Death Domain 2 3 4 5
  • Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein 3
  • Tumor Necrosis Factor Receptor-1-Associated Protein 3
  • TNFR1-Associated Death Domain Protein 3
  • TNFR1-Associated DEATH Domain Protein 4
  • Hs.89862 3

External Ids for TRADD Gene

Previous GeneCards Identifiers for TRADD Gene

  • GC16M057882
  • GC16M067565
  • GC16M066923
  • GC16M066964
  • GC16M065745
  • GC16M067188
  • GC16M053061

Summaries for TRADD Gene

Entrez Gene Summary for TRADD Gene

  • The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRADD Gene

TRADD (TNFRSF1A Associated Via Death Domain) is a Protein Coding gene. Among its related pathways are TWEAK Pathway and TNF signaling pathway. GO annotations related to this gene include identical protein binding and protein complex binding.

UniProtKB/Swiss-Prot for TRADD Gene

  • The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Gene Wiki entry for TRADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRADD Gene

Genomics for TRADD Gene

Regulatory Elements for TRADD Gene

Enhancers for TRADD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRADD on UCSC Golden Path with GeneCards custom track

Promoters for TRADD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRADD on UCSC Golden Path with GeneCards custom track

Genomic Location for TRADD Gene

Chromosome:
16
Start:
67,154,180 bp from pter
End:
67,160,298 bp from pter
Size:
6,119 bases
Orientation:
Minus strand

Genomic View for TRADD Gene

Genes around TRADD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRADD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRADD Gene

Proteins for TRADD Gene

  • Protein details for TRADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15628-TRADD_HUMAN
    Recommended name:
    Tumor necrosis factor receptor type 1-associated DEATH domain protein
    Protein Accession:
    Q15628
    Secondary Accessions:
    • B2RDS3
    • B3KQZ9
    • Q52NZ1

    Protein attributes for TRADD Gene

    Size:
    312 amino acids
    Molecular mass:
    34247 Da
    Quaternary structure:
    • Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
    SequenceCaution:
    • Sequence=AAA98482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRADD Gene

    Alternative splice isoforms for TRADD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRADD Gene

Proteomics data for TRADD Gene at MOPED

Post-translational modifications for TRADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRADD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRADD (TRADD)
  • Abcam antibodies for TRADD
  • Cloud-Clone Corp. Antibodies for TRADD

No data available for DME Specific Peptides for TRADD Gene

Domains & Families for TRADD Gene

Protein Domains for TRADD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRADD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15628

UniProtKB/Swiss-Prot:

TRADD_HUMAN :
  • Requires the intact death domain to associate with TNFRSF1A/TNFR1.
Domain:
  • Requires the intact death domain to associate with TNFRSF1A/TNFR1.
  • Contains 1 death domain.
genes like me logo Genes that share domains with TRADD: view

No data available for Gene Families for TRADD Gene

Function for TRADD Gene

Molecular function for TRADD Gene

GENATLAS Biochemistry:
tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed cell death apoptosis and activating NF-Kappa B distinctly
UniProtKB/Swiss-Prot Function:
The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with TRADD: view
genes like me logo Genes that share phenotypes with TRADD: view

Animal Models for TRADD Gene

MGI Knock Outs for TRADD:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRADD Gene

Localization for TRADD Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRADD Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRADD Gene COMPARTMENTS Subcellular localization image for TRADD gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 4
cytoskeleton 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRADD: view

Pathways & Interactions for TRADD Gene

genes like me logo Genes that share pathways with TRADD: view

SIGNOR curated interactions for TRADD Gene

Gene Ontology (GO) - Biological Process for TRADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7758105
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction IEA,TAS 7758105
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS --
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRADD: view

Drugs & Compounds for TRADD Gene

(2) Drugs for TRADD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TRADD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRADD: view

Transcripts for TRADD Gene

Unigene Clusters for TRADD Gene

TNFRSF1A-associated via death domain:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRADD Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TRADD Gene

GeneLoc Exon Structure for
TRADD
ECgene alternative splicing isoforms for
TRADD

Expression for TRADD Gene

mRNA expression in normal human tissues for TRADD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRADD Gene

This gene is overexpressed in Bone (13.1), Peripheral blood mononuclear cells (10.1), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRADD Gene



SOURCE GeneReport for Unigene cluster for TRADD Gene Hs.460996

mRNA Expression by UniProt/SwissProt for TRADD Gene

Q15628-TRADD_HUMAN
Tissue specificity: Found in all examined tissues.
genes like me logo Genes that share expression patterns with TRADD: view

Protein tissue co-expression partners for TRADD Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TRADD Gene

Orthologs for TRADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRADD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRADD 35
  • 84.99 (n)
  • 82.64 (a)
TRADD 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRADD 35
  • 86.86 (n)
  • 86.22 (a)
TRADD 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tradd 35
  • 80.11 (n)
  • 77.1 (a)
Tradd 16
Tradd 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRADD 35
  • 99.68 (n)
  • 99.35 (a)
TRADD 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tradd 35
  • 79.78 (n)
  • 77.42 (a)
oppossum
(Monodelphis domestica)
Mammalia TRADD 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRADD 35
  • 57.67 (n)
  • 52.25 (a)
TRADD 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRADD 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tradd 35
  • 48.78 (n)
  • 45.33 (a)
zebrafish
(Danio rerio)
Actinopterygii tradd 35
  • 49.81 (n)
  • 47.57 (a)
tradd 36
  • 42 (a)
OneToOne
Species with no ortholog for TRADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRADD Gene

ENSEMBL:
Gene Tree for TRADD (if available)
TreeFam:
Gene Tree for TRADD (if available)

Paralogs for TRADD Gene

No data available for Paralogs for TRADD Gene

Variants for TRADD Gene

Sequence variations from dbSNP and Humsavar for TRADD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs13312723 -- 67,157,793(-) GCCCC(C/G)GCTGG intron-variant
rs13312724 -- 67,157,707(-) GACAG(C/G)GAAGG intron-variant
rs13312725 -- 67,156,261(-) CACCA(C/G)CCGGC intron-variant
rs13312726 -- 67,156,071(-) GAGCC(A/C)CTCTT intron-variant, utr-variant-5-prime
rs13312727 -- 67,154,540(-) GGCCT(A/C)TCTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRADD Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680

Variation tolerance for TRADD Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRADD Gene

Human Gene Mutation Database (HGMD)
TRADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRADD Gene

Disorders for TRADD Gene

Relevant External Links for TRADD

Genetic Association Database (GAD)
TRADD
Human Genome Epidemiology (HuGE) Navigator
TRADD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRADD

No disorders were found for TRADD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRADD Gene

Publications for TRADD Gene

  1. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PMID: 7758105) Hsu H. … Goeddel D.V. (Cell 1995) 2 3 4 23 67
  2. The role of TRADD in death receptor signaling. (PMID: 22333735) Pobezinskaya Y.L. … Liu Z. (Cell Cycle 2012) 2 3
  3. Up-regulated renal expression of TNF-alpha signalling adapter proteins in lupus glomerulonephritis. (PMID: 19151112) Zhu L. … Yu X. (Lupus 2009) 3 23
  4. The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. (PMID: 18198944) Schneider F. … Kieser A. (PLoS Biol. 2008) 3 23
  5. Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS. (PMID: 18661484) Dechant M.J. … Fellenberg J. (Pediatr Blood Cancer 2008) 3 23

Products for TRADD Gene

Sources for TRADD Gene

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