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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRADD Gene

protein-coding   GIFtS: 66
GCID: GC16M067188

TNFRSF1A-Associated Via Death Domain

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TNFRSF1A-Associated Via Death Domain1 2 3
TNFR1-Associated DEATH Domain Protein2 3
Tumor Necrosis Factor Receptor Type 1 Associated Death Domain Protein2
Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein2
Tumor Necrosis Factor Receptor-1-Associated Protein2

External Ids:    HGNC: 120301   Entrez Gene: 87172   Ensembl: ENSG000001028717   OMIM: 6035005   UniProtKB: Q156283   

Export aliases for TRADD gene to outside databases

Previous GC identifers: GC16M057882 GC16M067565 GC16M066923 GC16M066964 GC16M065745 GC16M053061


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRADD Gene:
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1
and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2,
reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated
apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is
involved in the Fas-induced cell death pathway. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRADD Gene: 
TRADD (TNFRSF1A-associated via death domain) is a protein-coding gene. Diseases associated with TRADD include north american indian childhood cirrhosis, and patent ductus arteriosus, and among its related super-pathways are DR3 Signaling and Apoptosis and survival Caspase cascade. GO annotations related to this gene include kinase binding and identical protein binding.

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform
p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12
and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically
associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.
Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

Gene Wiki entry for TRADD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRADD gene promoter:
         p53   AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRADD promoter sequence
   Search SABiosciences Chromatin IP Primers for TRADD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRADD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

TRADD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRADD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067188:  view genomic region     (about GC identifiers)

Start:
67,188,083 bp from pter      End:
67,194,201 bp from pter
Size:
6,119 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628 (See protein sequence)
Recommended Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein  
Size: 312 amino acids; 34247 Da
Subunit: Interacts with TRIP12 (By similarity). Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD,
HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton. Note=Shuttles
between the cytoplasm and the nucleus (By similarity)
Sequence caution: Sequence=AAA98482.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TRADD:
1F2H (3D)        1F3V (3D)    
Secondary accessions: B2RDS3 Q52NZ1

Explore the universe of human proteins at neXtProt for TRADD: NX_Q15628

Explore proteomics data for TRADD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15628

  • TRADD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRADD Protein Expression
    REFSEQ proteins: NP_003780.1  
    ENSEMBL proteins: 
     ENSP00000341268   ENSP00000462591  
    Reactome Protein details: Q15628
    Human Recombinant Protein Products for TRADD: 
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    Novus Biologicals TRADD Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRADD 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA11684708
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0043235receptor complex IDA8612133

    TRADD for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRADD 
    Cloud-Clone Corp. CLIAs for TRADD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009095 TRADD_N
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain

    Graphical View of Domain Structure for InterPro Entry Q15628

    ProtoNet protein and cluster: Q15628

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
    Domain: Requires the intact death domain to associate with TNFRSF1A/TNFR1
    Similarity: Contains 1 death domain


    TRADD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRADD_HUMAN, Q15628
    Function: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform
    p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12
    and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically
    associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD.
    Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B

         Genatlas biochemistry entry for TRADD:
    tumor necrosis receptor 1,associated protein interacting with cytoplasmic domain of TNFRSF1A,mediating programmed
    cell death apoptosis and activating NF-Kappa B distinctly

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding IPI1040062
    GO:0019900kinase binding IPI8612133
    GO:0042802identical protein binding IPI11684708
    GO:0060090binding, bridging IPI8612133
         
    TRADD for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tradd):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 

    TRADD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRADD: Traddtm1.1Mak Traddtm1.1Zgl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRADD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRADD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRADD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRADD 

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRADD:
    hsa-miR-324-3p
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TRADD 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRADD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRADD About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TWEAK Pathway0.87
    Apoptosis and survival TNFR1 signaling pathway0.52
    DR3 Signaling0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    TNFR1 Pathway0.56
    Apoptotic Pathways Triggered By HIV10.42
    TNF Signaling0.55
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    314-3-3 Induced Apoptosis
    Apoptosis0.37
    14-3-3 Induced Apoptosis0.37
    4Apoptosis and survival Apoptotic TNF-family pathways
    Apoptosis and survival Apoptotic TNF-family pathways0.35
    Apoptosis Signaling Pathways0.35
    5Regulation by c-FLIP
    Extrinsic Pathway for Apoptosis0.93
    Dimerization of procaspase-80.90
    Death Receptor Signalling0.93
    Caspase-8 activation0.90
    Regulation by c-FLIP0.90
    TNF signaling0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/8 EMD Millipore Pathways for TRADD (see all 8)
        Transcription NF-kB signaling pathway
    Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    1 R&D Systems Pathway for TRADD
        Apoptosis Signaling Pathways

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TRADD (see all 21)
        Caspase Cascade
    MAPK Signaling
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    TRAF Pathway

    1 Cell Signaling Technology (CST) Pathway for TRADD
        Apoptosis and Autophagy

    5/8 GeneGo (Thomson Reuters) Pathways for TRADD (see all 8)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Immune response IL-9 signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
    Apoptosis and survival TNFR1 signaling pathway

    5/11 BioSystems Pathways for TRADD (see all 11)
        EBV LMP1 signaling
    Apoptosis
    Apoptosis Modulation and Signaling
    p38 MAPK Signaling Pathway
    Integrated Breast Cancer Pathway

    2 Sino Biological Pathways for TRADD 
        TNF Signaling
    Death Receptor Signaling

    5/7        Reactome Pathways for TRADD (see all 7)
        Death Receptor Signalling
    TNF signaling
    Extrinsic Pathway for Apoptosis
    Caspase-8 activation
    Dimerization of procaspase-8


    5/9         Kegg Pathways  (Kegg details for TRADD) (see all 9):
        NF-kappa B signaling pathway
    Apoptosis
    RIG-I-like receptor signaling pathway
    TNF signaling pathway
    Adipocytokine signaling pathway


    TRADD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRADD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/144 Interacting proteins for TRADD (Q156281, 2, 3 ENSP000003412684) via UniProtKB, MINT, STRING, and/or I2D (see all 144)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49485 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49485 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49485 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49485 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49485 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process TAS--
    GO:0007165signal transduction TAS7758105
    GO:0008625extrinsic apoptotic signaling pathway via death domain receptors TAS8612133
    GO:0033209tumor necrosis factor-mediated signaling pathway TAS8612133

    TRADD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRADD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRADD

    4 Novoseek inferred chemical compound relationships for TRADD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 74 2 17439942 (1), 17673602 (1)
    ceramide 32.9 3 12374208 (1), 10599977 (1), 10792026 (1)
    cysteine 2 2 9427646 (1), 10812970 (1)
    serine 0 1 15761471 (1)

    Search CenterWatch for drugs/clinical trials and news about TRADD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRADD gene (2 alternative transcripts): 
    NM_003789.3  NM_153425.1  

    Unigene Cluster for TRADD:

    TNFRSF1A-associated via death domain
    Hs.460996  [show with all ESTs]
    Unigene Representative Sequence: AK090673
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345057(uc002eri.1) ENST00000486556(uc002erh.1) ENST00000566247
    ENST00000563348(uc010vjb.1) ENST00000566104
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK090673.1 AK301593.1 AK315654.1 BC004491.2 BT006934.1 L41690.1 

    6 DOTS entries:

    DT.86852420  DT.100023011  DT.100754374  DT.91786845  DT.75103386  DT.91983549 

    24/138 AceView cDNA sequences (see all 138):

    BE272574 NM_153425 AW138709 L41690 CK819365 CB054809 AI633660 BT006934 
    NM_003789 BE326626 AI131201 BC004491 AA748993 AI344303 BF222501 AA741438 
    BQ707739 AW299865 AK090673 AA916906 BM473554 BE464241 BQ709164 BE795807 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRADD    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
    SP1:                    -           -     -                     
    SP2:                    -           -                           
    SP3:                                -     -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for TRADD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRADD expression in normal human tissues (normalized intensities)      TRADD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACCTTG
    TRADD Expression
    About this image


    TRADD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             t cells   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             uterus, pre-menopause ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   

    See TRADD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRADD

    SOURCE GeneReport for Unigene cluster: Hs.460996

    UniProtKB/Swiss-Prot: TRADD_HUMAN, Q15628
    Tissue specificity: Found in all examined tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including TRADD (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              TNF Ligands & Receptors in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRADD gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tradd1 , 5 TNFRSF1A-associated via death domain1, 5 80.11(n)1
    77.1(a)1
      8 (53.04 cM)5
    716091  NM_001033161.21  NP_001028333.11 
     1052582865 
    chicken
    (Gallus gallus)
    Aves TRADD1 TNFRSF1A-associated via death domain 57.55(n)
    52.25(a)
      415700  XM_414067.3  XP_414067.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRADD6
    TNFRSF1A-associated via death domain
    50(a)
    1 ↔ 1
    5(108485662-108495806)
    zebrafish
    (Danio rerio)
    Actinopterygii tradd1 tnfrsf1a-associated via death domain 49.19(n)
    47.19(a)
      58130  NM_131607.2  NP_571682.1 


    ENSEMBL Gene Tree for TRADD (if available)
    TreeFam Gene Tree for TRADD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/82 SNPs in TRADD are shown (see all 82)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3773067911,2
    C--67187590(+) AAAAA-/TTA   
       AAATT
    AAAAA
    1 -- ds50010--------
    rs1901518101,2
    --67187678(+) AAAAAC/TCCACA 1 -- ds50010--------
    rs129181211,2
    C,F,H--67187795(+) CTGTCC/TCCTGC 1 -- ds50019Minor allele frequency- T:0.04NS NA 1356
    rs133349451,2
    H--67187874(+) tttgaG/Aacagg 1 -- ds50011Minor allele frequency- A:0.00NS 120
    rs133127291,2
    C,F--67187947(-) GAGCAT/CGGAAG 1 -- ds50012Minor allele frequency- C:0.04NS 78
    rs1478463321,2
    C--67188140(+) TTCGGG/TGTCCC 1 -- ut310--------
    rs133127281,2
    C,F--67188189(-) GAAGTA/TAAACA 1 -- ut3110Minor allele frequency- T:0.06NS CSA WA 846
    rs1920395061,2
    --67188278(+) TGGCTA/GTAAGC 1 -- ut310--------
    rs1413640391,2
    --67188285(+) AAGCCC/GCGCTT 1 -- ut310--------
    rs1435364771,2
    C--67188353(+) TATCAA/CAGTAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRADD (67188083 - 67194201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TRADD:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2887n71CNV Loss21882294
    dgv2888n71CNV Loss21882294
    nsv906794CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv827707CNV Loss20364138
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680


    Human Gene Mutation Database (HGMD): TRADD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRADD
    DNA2.0 Custom Variant and Variant Library Synthesis for TRADD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603500    OMIM disorders: --

    20/43 diseases for TRADD (see all 43):    About MalaCards
    north american indian childhood cirrhosis    patent ductus arteriosus    epidermolysis bullosa simplex    burkitt's lymphoma
    epidermolysis bullosa    ankylosing spondylitis    keloids    lupus nephritis
    diphtheria    spondylitis    nephritis    ectodermal dysplasia
    hepatitis c    colon adenocarcinoma    lymphoblastic leukemia    myelodysplastic syndromes
    systemic lupus erythematosus    multiple myeloma    glomerulonephritis    hodgkin's lymphoma


    TRADD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for TRADD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 74.4 48 8245538 (2), 16611992 (2), 1910814 (1), 1922108 (1) (see all 41)
    tumors 60.5 45 8245538 (2), 18713013 (2), 16940186 (2), 1910814 (1) (see all 40)
    burkitt lymphoma 17.2 1 10409763 (1)
    inflammation 15.8 1 16470584 (1)
    cancer 6.93 1 19904742 (1)
    lymphoblastic leukemia acute 0 1 17378240 (1)
    breast cancer 0 2 12604596 (2)
    metastasis 0 1 15991280 (1)
    hepatitis c 0 1 11336543 (1)
    melanoma 0 1 8144583 (1)

    Genetic Association Database (GAD): TRADD
    Human Genome Epidemiology (HuGE) Navigator: TRADD (10 documents)

    Export disorders for TRADD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRADD gene, integrated from 9 sources (see all 213):
    (articles sorted by number of sources associating them with TRADD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. (PubMed id 7758105)1, 2, 3, 9 Hsu H.... Goeddel D.V. (1995)
    2. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)1, 2, 9 Inada H.... Inagaki M. (2001)
    3. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (2008)
    4. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 9 Zhang H.... Min W. (2004)
    5. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)1, 2, 9 Hsu H.... Goeddel D.V. (1996)
    6. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PubMed id 18990758)1, 4, 9 Cerhan J.R....Slager S.L. (2008)
    7. Association of STAT3 and TNFRSF1A with ankylosing spo ndylitis in Han Chinese. (PubMed id 21068102)1, 4 Davidson S.I....Xu H. (2010)
    8. The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1- associated death domain (TRADD). (PubMed id 19854717)1, 4 Pointon J.J....Wordsworth B.P. (2010)
    9. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    10. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8717 HGNC: 12030 AceView: TRADD Ensembl:ENSG00000102871 euGenes: HUgn8717
    ECgene: TRADD Kegg: 8717 H-InvDB: TRADD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRADD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRADD Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/tradd/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRADD gene:
    Search GeneIP for patents involving TRADD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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