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Aliases for TRAC Gene

Aliases for TRAC Gene

  • T Cell Receptor Alpha Constant 2 3
  • IMD7 3 6
  • TRCA 3 6
  • TCRA 3 4
  • TRA 3 6

External Ids for TRAC Gene

Summaries for TRAC Gene

GeneCards Summary for TRAC Gene

TRAC (T Cell Receptor Alpha Constant) is a Protein Coding gene. Diseases associated with TRAC include hypersensitivity reaction type ii disease and immunodeficiency 7, tcr-alpha/beta deficient. Among its related pathways are Class I MHC mediated antigen processing and presentation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include peptide antigen binding and MHC protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAC Gene

Genomics for TRAC Gene

Genomic Location for TRAC Gene

Start:
22,281,105 bp from pter
End:
22,552,155 bp from pter
Size:
271,051 bases
Orientation:
Plus strand

Genomic View for TRAC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAC Gene

No data available for Regulatory Elements for TRAC Gene

Proteins for TRAC Gene

  • Protein details for TRAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01848-TCA_HUMAN
    Recommended name:
    T-cell receptor alpha chain C region
    Protein Accession:
    P01848
    Secondary Accessions:

    Protein attributes for TRAC Gene

    Size:
    142 amino acids
    Molecular mass:
    15928 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions
    • This alpha chain C region shows sequence homology to its beta chain counterpart
    • This clone was isolated from a human leukemic T-cell line, Jurkat
    SequenceCaution:
    • Sequence=CAA26435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAC Gene

neXtProt entry for TRAC Gene

Proteomics data for TRAC Gene at MOPED

Post-translational modifications for TRAC Gene

No Post-translational modifications

Other Protein References for TRAC Gene

No data available for DME Specific Peptides for TRAC Gene

Domains for TRAC Gene

Gene Families for TRAC Gene

HGNC:
  • TRAS :T cell receptors / TRA locus

Protein Domains for TRAC Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TRAC: view

No data available for UniProtKB/Swiss-Prot for TRAC Gene

Function for TRAC Gene

Gene Ontology (GO) - Molecular Function for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TRAC: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRAC Gene

Localization for TRAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAC Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAC Gene COMPARTMENTS Subcellular localization image for TRAC gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAC: view

Pathways for TRAC Gene

genes like me logo Genes that share pathways with TRAC: view

Gene Ontology (GO) - Biological Process for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031295 T cell costimulation TAS --
GO:0050776 regulation of immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRAC: view

Compounds for TRAC Gene

(1) Drugbank Compounds for TRAC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Indolebutyric Acid
133-32-4 target
genes like me logo Genes that share compounds with TRAC: view

Transcripts for TRAC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRAC Gene

No ASD Table

Relevant External Links for TRAC Gene

GeneLoc Exon Structure for
TRAC
ECgene alternative splicing isoforms for
TRAC

Expression for TRAC Gene

mRNA expression in normal human tissues for TRAC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRAC Gene

This gene is overexpressed in Whole Blood (17.3) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRAC Gene

genes like me logo Genes that share expressions with TRAC: view

Orthologs for TRAC Gene

Evolution for TRAC Gene

ENSEMBL:
Gene Tree for TRAC (if available)
TreeFam:
Gene Tree for TRAC (if available)

No data available for Orthologs for TRAC Gene

Paralogs for TRAC Gene

Selected SIMAP similar genes for TRAC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAC: view

No data available for Paralogs for TRAC Gene

Variants for TRAC Gene

Relevant External Links for TRAC Gene

HapMap Linkage Disequilibrium report
TRAC
Human Gene Mutation Database (HGMD)
TRAC

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for TRAC Gene

Disorders for TRAC Gene

(1) OMIM Diseases for TRAC Gene (186880)

UniProtKB/Swiss-Prot

TCA_HUMAN
  • Immunodeficiency 7 (IMD7) [MIM:615387]: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta. {ECO:0000269 PubMed:21206088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRAC

Genetic Association Database (GAD)
TRAC
Human Genome Epidemiology (HuGE) Navigator
TRAC
genes like me logo Genes that share disorders with TRAC: view

Publications for TRAC Gene

  1. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. (PMID: 3875483) Rabbitts T.H. … Goodfellow P.N. (EMBO J. 1985) 2 3 4
  2. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 3
  3. Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. (PMID: 3873654) Yanagi Y. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 1985) 3 4
  4. The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. (PMID: 12429093) Kjer-Nielsen L. … Rossjohn J. (Structure 2002) 3 4
  5. A structural basis for immunodominant human T cell receptor recognition. (PMID: 12796775) Stewart-Jones G.B.E. … Jones E.Y. (Nat. Immunol. 2003) 3 4

Products for TRAC Gene

Sources for TRAC Gene

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