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Aliases for TRAC Gene

Aliases for TRAC Gene

  • T Cell Receptor Alpha Constant 2 3
  • TCRA 3 4
  • IMD7 3
  • TRCA 3
  • TRA 3

External Ids for TRAC Gene

Previous GeneCards Identifiers for TRAC Gene

  • GC14U990391
  • GC14P021006
  • GC14P022086
  • GC14P022539
  • GC14P003134
  • GC14P023255
  • GC14P023318
  • GC14P023387
  • GC14P023463
  • GC14P023543
  • GC14P023636
  • GC14P023790

Summaries for TRAC Gene

GeneCards Summary for TRAC Gene

TRAC (T Cell Receptor Alpha Constant) is a Protein Coding gene. Diseases associated with TRAC include tcr-alpha-beta-positive t-cell deficiency and immunodeficiency 7, tcr-alpha/beta deficient. Among its related pathways are Immune System and G-protein signaling_Regulation of RAC1 activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAC Gene

Genomics for TRAC Gene

Genomic Location for TRAC Gene

Chromosome:
14
Start:
22,281,105 bp from pter
End:
22,552,155 bp from pter
Size:
271,051 bases
Orientation:
Plus strand

Genomic View for TRAC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TRAC Gene

No data available for Regulatory Elements for TRAC Gene

Proteins for TRAC Gene

  • Protein details for TRAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01848-TCA_HUMAN
    Recommended name:
    T-cell receptor alpha chain C region
    Protein Accession:
    P01848

    Protein attributes for TRAC Gene

    Size:
    142 amino acids
    Molecular mass:
    15928 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions
    • This alpha chain C region shows sequence homology to its beta chain counterpart
    • This clone was isolated from a human leukemic T-cell line, Jurkat
    SequenceCaution:
    • Sequence=CAA26435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAC Gene

neXtProt entry for TRAC Gene

Proteomics data for TRAC Gene at MOPED

Post-translational modifications for TRAC Gene

  • Glycosylation at Asn 34, Asn 61, Asn 68, and Asn 115

Other Protein References for TRAC Gene

No data available for DME Specific Peptides for TRAC Gene

Domains & Families for TRAC Gene

Gene Families for TRAC Gene

Protein Domains for TRAC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAC: view

No data available for UniProtKB/Swiss-Prot for TRAC Gene

Function for TRAC Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAC Gene

Localization for TRAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAC Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAC: view

No data available for Subcellular locations from COMPARTMENTS for TRAC Gene

Pathways & Interactions for TRAC Gene

genes like me logo Genes that share pathways with TRAC: view

Interacting Proteins for TRAC Gene

Selected Interacting proteins: P01848-TCA_HUMAN for TRAC Gene via I2D UniProtKB MINT

Gene Ontology (GO) - Biological Process for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031295 T cell costimulation TAS --
GO:0050776 regulation of immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRAC: view

No data available for SIGNOR curated interactions for TRAC Gene

Drugs & Compounds for TRAC Gene

(1) Drugs for TRAC Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-Indolebutyric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAC: view

Transcripts for TRAC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRAC Gene

No ASD Table

Relevant External Links for TRAC Gene

GeneLoc Exon Structure for
TRAC
ECgene alternative splicing isoforms for
TRAC

Expression for TRAC Gene

mRNA expression in normal human tissues for TRAC Gene

mRNA differential expression in normal tissues according to GTEx for TRAC Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for TRAC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.8) and CD8 Tcells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRAC Gene



genes like me logo Genes that share expression patterns with TRAC: view

Protein tissue co-expression partners for TRAC Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRAC Gene

Orthologs for TRAC Gene

Evolution for TRAC Gene

ENSEMBL:
Gene Tree for TRAC (if available)
TreeFam:
Gene Tree for TRAC (if available)

No data available for Orthologs for TRAC Gene

Paralogs for TRAC Gene

(2) SIMAP similar genes for TRAC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAC: view

No data available for Paralogs for TRAC Gene

Variants for TRAC Gene

Relevant External Links for TRAC Gene

HapMap Linkage Disequilibrium report
TRAC
Human Gene Mutation Database (HGMD)
TRAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAC Gene

Disorders for TRAC Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAC Gene - From: OMIM and Orphanet

Disorder Aliases PubMed IDs
tcr-alpha-beta-positive t-cell deficiency
  • tcr-alpha-beta+ t-cell deficiency
immunodeficiency 7, tcr-alpha/beta deficient
  • immunodeficiency 7
- elite association
Search TRAC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCA_HUMAN
  • Immunodeficiency 7 (IMD7) [MIM:615387]: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta. {ECO:0000269 PubMed:21206088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRAC

Genetic Association Database (GAD)
TRAC
Human Genome Epidemiology (HuGE) Navigator
TRAC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAC
genes like me logo Genes that share disorders with TRAC: view

No data available for Genatlas for TRAC Gene

Publications for TRAC Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop B.F. … Hood L. (Genomics 1994) 2 67
  2. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. (PMID: 3875483) Rabbitts T.H. … Goodfellow P.N. (EMBO J. 1985) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Mutation in the TCRI+ subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRI+I^+ T cells. (PMID: 21206088) Morgan N.V. … Maher E.R. (J. Clin. Invest. 2011) 67
  5. [T cell receptor constant alpha chain gene +1592C/T polymorphism may not be associated with IgA nephropathy]. (PMID: 20965830) Li S.L. … Guo P.W. (Nan Fang Yi Ke Da Xue Xue Bao 2010) 67

Products for TRAC Gene

Sources for TRAC Gene

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