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Aliases for TRAC Gene

Aliases for TRAC Gene

  • T-Cell Receptor Alpha Constant 2 3 5
  • TCRA 3 4
  • T Cell Receptor Alpha Constant 2
  • IMD7 3
  • TRCA 3
  • TRA 3

External Ids for TRAC Gene

Previous GeneCards Identifiers for TRAC Gene

  • GC14U990391
  • GC14P021006
  • GC14P022086
  • GC14P022539
  • GC14P003134
  • GC14P023255
  • GC14P023318
  • GC14P023387
  • GC14P023463
  • GC14P023543
  • GC14P023636
  • GC14P023790
  • GC14P022282
  • GC14P022713

Summaries for TRAC Gene

Entrez Gene Summary for TRAC Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAC Gene

TRAC (T-Cell Receptor Alpha Constant) is a Protein Coding gene. Diseases associated with TRAC include Immunodeficiency 7, Tcr-Alpha/Beta Deficient. Among its related pathways are G-protein signaling_Rap1A regulation pathway and Translocation of ZAP-70 to Immunological synapse.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAC Gene

Genomics for TRAC Gene

Regulatory Elements for TRAC Gene

Enhancers for TRAC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRAC on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAC Gene

Chromosome:
14
Start:
22,203,093 bp from pter
End:
22,552,155 bp from pter
Size:
349,063 bases
Orientation:
Plus strand

Genomic View for TRAC Gene

Genes around TRAC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAC Gene

Proteins for TRAC Gene

  • Protein details for TRAC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01848-TCA_HUMAN
    Recommended name:
    T-cell receptor alpha chain C region
    Protein Accession:
    P01848

    Protein attributes for TRAC Gene

    Size:
    142 amino acids
    Molecular mass:
    15928 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.
    • This alpha chain C region shows sequence homology to its beta chain counterpart.
    • This clone was isolated from a human leukemic T-cell line, Jurkat.
    SequenceCaution:
    • Sequence=CAA26435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAC Gene

neXtProt entry for TRAC Gene

Post-translational modifications for TRAC Gene

  • Glycosylation at Asn 34, Asn 61, Asn 68, and Asn 115

Other Protein References for TRAC Gene

No data available for DME Specific Peptides for TRAC Gene

Domains & Families for TRAC Gene

Gene Families for TRAC Gene

Protein Domains for TRAC Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRAC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAC: view

No data available for UniProtKB/Swiss-Prot for TRAC Gene

Function for TRAC Gene

Human Phenotype Ontology for TRAC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAC Gene

Localization for TRAC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAC Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAC: view

No data available for Subcellular locations from COMPARTMENTS for TRAC Gene

Pathways & Interactions for TRAC Gene

genes like me logo Genes that share pathways with TRAC: view

Interacting Proteins for TRAC Gene

Gene Ontology (GO) - Biological Process for TRAC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031295 T cell costimulation TAS --
GO:0050776 regulation of immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRAC: view

No data available for SIGNOR curated interactions for TRAC Gene

Drugs & Compounds for TRAC Gene

(1) Drugs for TRAC Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-Indolebutyric acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with TRAC: view

Transcripts for TRAC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRAC Gene

No ASD Table

Relevant External Links for TRAC Gene

GeneLoc Exon Structure for
TRAC
ECgene alternative splicing isoforms for
TRAC

Expression for TRAC Gene

mRNA expression in normal human tissues for TRAC Gene

mRNA differential expression in normal tissues according to GTEx for TRAC Gene

This gene is overexpressed in Whole Blood (x17.3) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for TRAC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.8) and CD8 Tcells (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRAC Gene



Protein tissue co-expression partners for TRAC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAC Gene:

TRAC
genes like me logo Genes that share expression patterns with TRAC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRAC Gene

Orthologs for TRAC Gene

Evolution for TRAC Gene

ENSEMBL:
Gene Tree for TRAC (if available)
TreeFam:
Gene Tree for TRAC (if available)

No data available for Orthologs for TRAC Gene

Paralogs for TRAC Gene

(2) SIMAP similar genes for TRAC Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRAC: view

No data available for Paralogs for TRAC Gene

Variants for TRAC Gene

Relevant External Links for TRAC Gene

Human Gene Mutation Database (HGMD)
TRAC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAC Gene

Disorders for TRAC Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRAC Gene - From: OMIM and Orphanet

Disorder Aliases PubMed IDs
immunodeficiency 7, tcr-alpha/beta deficient
  • t-cell receptor-alpha/beta deficiency
- elite association - COSMIC cancer census association via MalaCards
Search TRAC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCA_HUMAN
  • Immunodeficiency 7 (IMD7) [MIM:615387]: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta. {ECO:0000269 PubMed:21206088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TRAC

Genetic Association Database (GAD)
TRAC
Human Genome Epidemiology (HuGE) Navigator
TRAC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAC
genes like me logo Genes that share disorders with TRAC: view

No data available for Genatlas for TRAC Gene

Publications for TRAC Gene

  1. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. (PMID: 3875483) Rabbitts T.H. … Goodfellow P.N. (EMBO J. 1985) 2 3 4 65
  2. Mutation in the TCRI+ subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRI+I^+ T cells. (PMID: 21206088) Morgan N.V. … Maher E.R. (J. Clin. Invest. 2011) 3 4 65
  3. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PMID: 19349973) Wollscheid B. … Watts J.D. (Nat. Biotechnol. 2009) 3 4 65
  4. TRAC variants associate with IgA nephropathy. (PMID: 19470682) Li R. … Wang Y. (J. Am. Soc. Nephrol. 2009) 3 46 65
  5. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. (PMID: 16079912) Li Y. … Mariuzza R.A. (EMBO J. 2005) 3 4 65

Products for TRAC Gene

Sources for TRAC Gene

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