Aliases for TRABD2B Gene
External Ids for TRABD2B Gene
Previous GeneCards Identifiers for TRABD2B Gene
GeneCards Summary for TRABD2B Gene
TRABD2B (TraB Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2A.
UniProtKB/Swiss-Prot for TRABD2B Gene
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.