TRABD2B Gene
protein-coding GIFtS: 31
GCID: GC01M048238
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TraB domain containing 2B
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Aliases
for TRABD2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TraB Domain Containing 2B1 2 | | TIKI22 3 | | TRAB Domain-Containing Protein 2B2 3 | | Metalloprotease TIKI22 | | UPF0632 Protein A2 | | EC 3.4.-.-3 |
Export aliases for TRABD2B gene to outside databases |
Summaries
for TRABD2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TIKI2_HUMAN, A6NFA1Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage ofthe 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form largedisulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for headformation
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Genomic Views
for TRABD2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TRABD2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRABD2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRABD2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p33 Ensembl cytogenetic band: 1p33 HGNC cytogenetic band: 1p33TRABD2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M048238: view genomic region
(about GC identifiers)
Start:
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48,226,200 bp from pter |
End:
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48,462,567 bp from pter |
Size:
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236,368 bases |
Orientation:
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minus strand |
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Proteins
for TRABD2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TIKI2_HUMAN, A6NFA1 (See
protein sequence)Recommended Name: Metalloprotease TIKI2 precursor Size: 517 amino acids; 57421 Da
Cofactor: Divalent metal cations. Manganese or cobalt
Subcellular location: Cell membrane; Single-pass type I membrane protein
Miscellaneous: Was named TIKI in reference to large-headed humanoid in Polynesian mythology (PubMed:22726442)
Secondary accessions: I6U4Y0Explore the universe of human proteins at neXtProt for TRABD2B: NX_A6NFA1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NFA1
TRABD2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001181915.1
ENSEMBL proteins: ENSP00000456730
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005887 | integral to plasma membrane |
IDA | -- | | GO:0016021 | integral to membrane |
-- | -- | | GO:0031301 | integral to organelle membrane |
IDA | -- |
TRABD2B for ontologies About GeneDecksing
TRABD2B Antibody Products:
Assay Products for TRABD2B: |
Protein
Domains /
Families
for TRABD2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRABD2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NFA1ProtoNet protein and cluster: A6NFA1 UniProtKB/Swiss-Prot: TIKI2_HUMAN, A6NFA1Similarity: Belongs to the TIKI family |
Function
for TRABD2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TIKI2_HUMAN, A6NFA1Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage ofthe 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form largedisulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for headformationEnzyme regulation: Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator.Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors forserine, cysteine, and aspartic proteases and aminopeptidasesEnzyme Number (IUBMB): EC 3.4.-.-1
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TRABD2B for ontologies About GeneDecksing
|
Pathways & Interactions
for TRABD2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRABD2B
1 Interacting protein for TRABD2B (A6NFA11) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TRABD2B for ontologies About GeneDecksing
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Drugs & Compounds
for TRABD2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRABD2B
Search CenterWatch for drugs/clinical trials and news about TRABD2B / TIKI2 
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Transcripts
for TRABD2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRABD2B gene: NM_001194986.1 Unigene Cluster for TRABD2B: TraB domain containing 2B Hs.61504 [show with all ESTs]Unigene Representative Sequence: NM_0011949862 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371865(uc021ong.1) ENST00000435576
Additional cDNA sequence: AK090467.1 JQ653416.1 4 DOTS entries: DT.209423 DT.452375 DT.97808171 DT.409534 20 AceView cDNA sequences: BX097561 AI393670 BQ044942 AI936385 AA400073 AW138156 AW270145 AA401583 AI762919 AA916329 BQ337490 AA128516 AA128517 H78374 AA197273 AA205813 BQ328102 BI763444 AI262958 H78472
GeneLoc Exon Structure
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Expression
for TRABD2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TRABD2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRABD2B
SOURCE GeneReport for Unigene cluster: Hs.61504
SABiosciences Custom PCR Arrays for TRABD2B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TRABD2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRABD2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRABD2B |
Orthologs
for TRABD2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TRABD2B gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for TRABD2B (if available)
TreeFam Gene Tree for TRABD2B (if available) |
Paralogs
for TRABD2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRABD2B gene
- TRABD2A2
1 SIMAP similar gene for TRABD2B using alignment to 1 protein entry: TIKI2_HUMAN:TRABD2A
TRABD2B for paralogs About GeneDecksing
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Genomic Variants
for TRABD2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRABD2B (48226200 - 48462567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRABD2B: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TRABD2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRABD2B for disorders About MalaCards
TRABD2B for disorders About GeneDecksing
OMIM gene information: 614913
OMIM disorders: --
Export disorders for TRABD2B gene to outside databases
|
Publications
for TRABD2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRABD2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRABD2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Tiki1 is required for head formation via Wnt cleavage- oxidation and inactivation. (PubMed id 22726442)1, 2 Zhang X....He X. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- A genome-wide search for genetic influences and biolog ical pathways related to the brain's white matter integrity. (PubMed id 22425255)1 Lopez L.M....Deary I.J. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
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External Searches for TRABD2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TRABD2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRABD2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRABD2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRABD2B gene:
Search GeneIP for patents involving TRABD2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRABD2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRABD2B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRABD2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRABD2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRABD2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRABD2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRABD2B |
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| | | | Search Tocris compounds for TRABD2B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TRABD2B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRABD2B |
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