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Aliases for TRABD2B Gene

Aliases for TRABD2B Gene

  • TraB Domain Containing 2B 2 3 5
  • Heart, Kidney And Adipose-Enriched Transmembrane Protein Homolog 3 4
  • TRAB Domain-Containing Protein 2B 3 4
  • TIKI2 3 4
  • UPF0632 Protein A 3
  • EC 3.4.-.- 4
  • HKAT 4

External Ids for TRABD2B Gene

Previous GeneCards Identifiers for TRABD2B Gene

  • GC01M048238

Summaries for TRABD2B Gene

GeneCards Summary for TRABD2B Gene

TRABD2B (TraB Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2A.

UniProtKB/Swiss-Prot for TRABD2B Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2B Gene

Genomics for TRABD2B Gene

Regulatory Elements for TRABD2B Gene

Promoters for TRABD2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRABD2B on UCSC Golden Path with GeneCards custom track

Genomic Location for TRABD2B Gene

Chromosome:
1
Start:
47,760,528 bp from pter
End:
47,997,371 bp from pter
Size:
236,844 bases
Orientation:
Minus strand

Genomic View for TRABD2B Gene

Genes around TRABD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2B Gene

Proteins for TRABD2B Gene

  • Protein details for TRABD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFA1-TIKI2_HUMAN
    Recommended name:
    Metalloprotease TIKI2
    Protein Accession:
    A6NFA1
    Secondary Accessions:
    • I6U4Y0

    Protein attributes for TRABD2B Gene

    Size:
    517 amino acids
    Molecular mass:
    57421 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.

neXtProt entry for TRABD2B Gene

Proteomics data for TRABD2B Gene at MOPED

Post-translational modifications for TRABD2B Gene

  • Glycosylation at Asn 228 and Asn 335
  • Modification sites at PhosphoSitePlus

Other Protein References for TRABD2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRABD2B Gene

Domains & Families for TRABD2B Gene

Protein Domains for TRABD2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NFA1

UniProtKB/Swiss-Prot:

TIKI2_HUMAN :
  • Belongs to the TIKI family.
Family:
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TRABD2B Gene

Function for TRABD2B Gene

Molecular function for TRABD2B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator. Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases.
UniProtKB/Swiss-Prot Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2B Gene

Phenotypes for TRABD2B Gene

GenomeRNAi human phenotypes for TRABD2B:
genes like me logo Genes that share phenotypes with TRABD2B: view

Animal Model Products

CRISPR Products

miRNA for TRABD2B Gene

miRTarBase miRNAs that target TRABD2B

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD2B Gene

Localization for TRABD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRABD2B Gene COMPARTMENTS Subcellular localization image for TRABD2B gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TRABD2B: view

Pathways & Interactions for TRABD2B Gene

SuperPathways for TRABD2B Gene

No Data Available

Interacting Proteins for TRABD2B Gene

Selected Interacting proteins: A6NFA1-TIKI2_HUMAN for TRABD2B Gene via UniProtKB

Symbol External ID(s) Details
WNT3A (XENO)

Gene Ontology (GO) - Biological Process for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 22726442
GO:0008152 metabolic process IDA --
GO:0018158 protein oxidation IDA --
genes like me logo Genes that share ontologies with TRABD2B: view

No data available for Pathways by source and SIGNOR curated interactions for TRABD2B Gene

Drugs & Compounds for TRABD2B Gene

No Compound Related Data Available

Transcripts for TRABD2B Gene

mRNA/cDNA for TRABD2B Gene

Unigene Clusters for TRABD2B Gene

TraB domain containing 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2B Gene

No ASD Table

Relevant External Links for TRABD2B Gene

GeneLoc Exon Structure for
TRABD2B
ECgene alternative splicing isoforms for
TRABD2B

Expression for TRABD2B Gene

mRNA expression in normal human tissues for TRABD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2B Gene

This gene is overexpressed in Artery - Tibial (x9.3), Artery - Coronary (x7.0), Kidney - Cortex (x5.5), and Artery - Aorta (x4.3).

SOURCE GeneReport for Unigene cluster for TRABD2B Gene Hs.61504

genes like me logo Genes that share expression patterns with TRABD2B: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRABD2B Gene

Orthologs for TRABD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD2B 35
  • 99.29 (n)
  • 98.84 (a)
cow
(Bos Taurus)
Mammalia TRABD2B 35
  • 87.99 (n)
  • 89.13 (a)
dog
(Canis familiaris)
Mammalia TRABD2B 35
  • 85.74 (n)
  • 84.92 (a)
TRABD2B 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trabd2b 36
  • 89 (a)
OneToOne
Trabd2b 16
Trabd2b 35
  • 85.75 (n)
  • 89.92 (a)
oppossum
(Monodelphis domestica)
Mammalia TRABD2B 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRABD2B 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trabd2b 35
  • 85.89 (n)
  • 90.12 (a)
chicken
(Gallus gallus)
Aves TRABD2B 35
  • 73.37 (n)
  • 75.41 (a)
TRABD2B 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC566028 35
  • 68.98 (n)
  • 69.05 (a)
TRABD2B 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05G5.5 36
  • 27 (a)
OneToMany
C05G5.5 35
  • 42.84 (n)
  • 33.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TRABD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRABD2B Gene

ENSEMBL:
Gene Tree for TRABD2B (if available)
TreeFam:
Gene Tree for TRABD2B (if available)

Paralogs for TRABD2B Gene

Paralogs for TRABD2B Gene

(1) SIMAP similar genes for TRABD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRABD2B: view

Variants for TRABD2B Gene

Sequence variations from dbSNP and Humsavar for TRABD2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs191008 -- 47,965,666(-) AGTGG(A/G)AAGAG intron-variant
rs303912 -- 47,986,317(-) CCTCT(C/G)TAATT intron-variant
rs303913 -- 47,984,690(-) TAAAG(C/G)CTAGG intron-variant
rs303918 -- 47,962,327(-) ataac(A/G)tgcag intron-variant
rs303919 -- 47,961,560(-) gtctg(C/T)tcata intron-variant

Variation tolerance for TRABD2B Gene

Gene Damage Index Score: 5.35; 70.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRABD2B Gene

HapMap Linkage Disequilibrium report
TRABD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRABD2B Gene

Disorders for TRABD2B Gene

Relevant External Links for TRABD2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRABD2B

No disorders were found for TRABD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD2B Gene

Publications for TRABD2B Gene

  1. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis A.H. … He X. (Int. J. Dev. Biol. 2014) 2 3 67
  2. TIKI2 suppresses growth of osteosarcoma by targeting Wnt/I^-catenin pathway. (PMID: 24771064) Li R. … Zhang S. (Mol. Cell. Biochem. 2014) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity. (PMID: 22425255) Lopez L.M. … Deary I.J. (Neurobiol. Aging 2012) 3
  5. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X. … He X. (Cell 2012) 3

Products for TRABD2B Gene

Sources for TRABD2B Gene

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