Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRABD2B Gene

Aliases for TRABD2B Gene

  • TraB Domain Containing 2B 2 3 5
  • Heart, Kidney And Adipose-Enriched Transmembrane Protein Homolog 3 4
  • TRAB Domain-Containing Protein 2B 3 4
  • TIKI2 3 4
  • Metalloprotease TIKI2 3
  • UPF0632 Protein A 3
  • EC 3.4.-.- 4
  • HKAT 4

External Ids for TRABD2B Gene

Previous GeneCards Identifiers for TRABD2B Gene

  • GC01M048238

Summaries for TRABD2B Gene

GeneCards Summary for TRABD2B Gene

TRABD2B (TraB Domain Containing 2B) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2A.

UniProtKB/Swiss-Prot for TRABD2B Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2B Gene

Genomics for TRABD2B Gene

Regulatory Elements for TRABD2B Gene

Enhancers for TRABD2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F047332 0.9 FANTOM5 ENCODE 11.6 +663.1 663083 4.2 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 ENSG00000226252 FOXE3 EFCAB14-AS1 CMPK1 SKINT1L TRABD2B TAL1 LOC105378702 ENSG00000272491 LINC01389
GH01F047932 1.1 Ensembl ENCODE 5.7 +63.6 63566 2.8 KLF1 ZIC2 HIC1 ZFHX2 GLIS2 ZBTB48 ZNF366 PATZ1 PRDM10 ZNF600 TRABD2B GC01M047950 PIR61209 GC01P047902
GH01F047938 0.4 ENCODE 5.3 +58.7 58665 1.1 TRABD2B GC01M047950 PIR61209 GC01P047902
GH01F047848 0.6 ENCODE 5.3 +148.1 148091 1.3 HLF REST RAD21 TRABD2B LOC105378702 GC01P047902
GH01F047870 1.1 Ensembl ENCODE 5 +125.1 125071 3.0 ZNF133 KLF17 RAD21 RARA GLIS2 SCRT2 FOS EGR2 ZEB2 RCOR2 TRABD2B GC01P047902 LOC105378702
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRABD2B on UCSC Golden Path with GeneCards custom track

Promoters for TRABD2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744680 171 1601 ZNF2 YY1 GLIS2 ZNF143 ZNF263 SP3 REST ZNF610 SMARCA4 ZSCAN16

Genomic Location for TRABD2B Gene

Chromosome:
1
Start:
47,760,528 bp from pter
End:
47,997,371 bp from pter
Size:
236,844 bases
Orientation:
Minus strand

Genomic View for TRABD2B Gene

Genes around TRABD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2B Gene

Proteins for TRABD2B Gene

  • Protein details for TRABD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFA1-TIKI2_HUMAN
    Recommended name:
    Metalloprotease TIKI2
    Protein Accession:
    A6NFA1
    Secondary Accessions:
    • I6U4Y0

    Protein attributes for TRABD2B Gene

    Size:
    517 amino acids
    Molecular mass:
    57421 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.

neXtProt entry for TRABD2B Gene

Post-translational modifications for TRABD2B Gene

  • Glycosylation at Asn 228 and Asn 335
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRABD2B Gene

Domains & Families for TRABD2B Gene

Protein Domains for TRABD2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NFA1

UniProtKB/Swiss-Prot:

TIKI2_HUMAN :
  • Belongs to the TIKI family.
Family:
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TRABD2B Gene

Function for TRABD2B Gene

Molecular function for TRABD2B Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator. Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases.
UniProtKB/Swiss-Prot Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2B Gene

Gene Ontology (GO) - Molecular Function for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 22726442
GO:0005515 protein binding IPI 22726442
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TRABD2B: view

Phenotypes for TRABD2B Gene

GenomeRNAi human phenotypes for TRABD2B:
genes like me logo Genes that share phenotypes with TRABD2B: view

Animal Model Products

miRNA for TRABD2B Gene

miRTarBase miRNAs that target TRABD2B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD2B Gene

Localization for TRABD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2B Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRABD2B Gene COMPARTMENTS Subcellular localization image for TRABD2B gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22726442
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IDA 22726442
genes like me logo Genes that share ontologies with TRABD2B: view

Pathways & Interactions for TRABD2B Gene

SuperPathways for TRABD2B Gene

No Data Available

Interacting Proteins for TRABD2B Gene

Selected Interacting proteins: A6NFA1-TIKI2_HUMAN for TRABD2B Gene via UniProtKB

Symbol External ID(s) Details
WNT3A (XENO)

Gene Ontology (GO) - Biological Process for TRABD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 22726442
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 22726442
GO:0032461 positive regulation of protein oligomerization IDA 22726442
GO:1904808 positive regulation of protein oxidation IDA 22726442
genes like me logo Genes that share ontologies with TRABD2B: view

No data available for Pathways by source and SIGNOR curated interactions for TRABD2B Gene

Transcripts for TRABD2B Gene

mRNA/cDNA for TRABD2B Gene

Unigene Clusters for TRABD2B Gene

TraB domain containing 2B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2B Gene

No ASD Table

Relevant External Links for TRABD2B Gene

GeneLoc Exon Structure for
TRABD2B
ECgene alternative splicing isoforms for
TRABD2B

Expression for TRABD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRABD2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2B Gene

This gene is overexpressed in Artery - Tibial (x9.3), Artery - Coronary (x7.0), Kidney - Cortex (x5.5), and Artery - Aorta (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TRABD2B Gene:

TRABD2B

SOURCE GeneReport for Unigene cluster for TRABD2B Gene:

Hs.61504
genes like me logo Genes that share expression patterns with TRABD2B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRABD2B Gene

Orthologs for TRABD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD2B 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia TRABD2B 34
  • 87.99 (n)
rat
(Rattus norvegicus)
Mammalia Trabd2b 34
  • 85.89 (n)
mouse
(Mus musculus)
Mammalia Trabd2b 34 16 35
  • 85.75 (n)
dog
(Canis familiaris)
Mammalia TRABD2B 34 35
  • 85.74 (n)
oppossum
(Monodelphis domestica)
Mammalia TRABD2B 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRABD2B 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRABD2B 34 35
  • 73.37 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC566028 34
  • 68.98 (n)
TRABD2B 35
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05G5.5 34 35
  • 42.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for TRABD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRABD2B Gene

ENSEMBL:
Gene Tree for TRABD2B (if available)
TreeFam:
Gene Tree for TRABD2B (if available)

Paralogs for TRABD2B Gene

Paralogs for TRABD2B Gene

(1) SIMAP similar genes for TRABD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRABD2B: view

Variants for TRABD2B Gene

Sequence variations from dbSNP and Humsavar for TRABD2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1039129 -- 47,928,914(+) ATCTC(A/C)CAGGT intron-variant
rs1039130 -- 47,928,930(+) CCTAA(C/T)TGCTT intron-variant
rs10443227 -- 47,876,951(+) TCTAT(A/G)ATAGT intron-variant
rs10493130 -- 47,875,333(-) CATAT(C/T)TAGTG intron-variant
rs10493131 -- 47,921,755(+) TGATG(C/T)AATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRABD2B Gene

Variant ID Type Subtype PubMed ID
esv1265813 CNV deletion 17803354
esv2671445 CNV deletion 23128226
esv3577840 CNV loss 25503493
esv3585959 CNV gain 21293372
esv3585961 CNV loss 21293372
esv3585962 CNV loss 21293372
nsv1001126 CNV gain 25217958
nsv1003161 CNV loss 25217958
nsv1113115 CNV deletion 24896259
nsv1122341 CNV deletion 24896259
nsv1126198 CNV deletion 24896259
nsv461450 CNV loss 19166990
nsv511691 CNV loss 21212237
nsv546191 CNV loss 21841781
nsv766 CNV insertion 18451855
nsv829760 CNV loss 17160897
nsv998583 CNV gain 25217958

Variation tolerance for TRABD2B Gene

Gene Damage Index Score: 5.35; 70.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRABD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRABD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRABD2B Gene

Disorders for TRABD2B Gene

Relevant External Links for TRABD2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRABD2B

No disorders were found for TRABD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD2B Gene

Publications for TRABD2B Gene

  1. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis A.H. … He X. (Int. J. Dev. Biol. 2014) 2 3 64
  2. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X. … He X. (Cell 2012) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Characterization of Tiki, a New Family of Wnt-specific Metalloproteases. (PMID: 26631728) Zhang X. … He X. (J. Biol. Chem. 2016) 3 64
  5. TIKI2 suppresses growth of osteosarcoma by targeting Wnt/I^-catenin pathway. (PMID: 24771064) Li R. … Zhang S. (Mol. Cell. Biochem. 2014) 3 64

Products for TRABD2B Gene

Sources for TRABD2B Gene

Content
Loading form....