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Aliases for TRABD2A Gene

Aliases for TRABD2A Gene

  • TraB Domain Containing 2A 2 3 5
  • TRAB Domain-Containing Protein 2A 3 4
  • C2orf89 3 4
  • TIKI1 3 4
  • Chromosome 2 Open Reading Frame 89 2
  • UPF0632 Protein C2orf89 3
  • Metalloprotease TIKI1 3
  • EC 3.4.-.- 4

External Ids for TRABD2A Gene

Previous HGNC Symbols for TRABD2A Gene

  • C2orf89

Previous GeneCards Identifiers for TRABD2A Gene

  • GC02M085049

Summaries for TRABD2A Gene

GeneCards Summary for TRABD2A Gene

TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2B.

UniProtKB/Swiss-Prot for TRABD2A Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2A Gene

Genomics for TRABD2A Gene

Regulatory Elements for TRABD2A Gene

Enhancers for TRABD2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G084842 1.3 FANTOM5 Ensembl ENCODE dbSUPER 22.7 +61.4 61392 5.5 STAT1 NFE2 ATF2 TRABD2A RPS2P17 DNAH6 RN7SL113P ENSG00000276362 GC02P084793
GH02G084856 1.3 Ensembl ENCODE dbSUPER 20.7 +49.8 49821 0.7 ESRRA KLF1 FOXA2 ATF1 JUN BACH1 FOSL1 NR2F6 ZNF584 CREM TRABD2A RPS2P17 GC02P084858 ENSG00000276362
GH02G084956 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -51.9 -51870 4.7 FOXA2 SIN3A FEZF1 SLC30A9 FOS DEK ZNF263 SP3 REST GLIS1 LOC100996506 C2orf68 RPS2P17 TRABD2A GC02M084965 GC02M084928
GH02G085275 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.7 -370.5 -370492 3.7 CBX3 SREBF2 SIN3A RAD21 SCRT2 FOS DEK SP5 ZBTB11 REST TCF7L1 RNU6-674P TRABD2A RPS2P17 SH2D6 LOC100996506 ATOH8 TMEM150A TMSB10 ENSG00000230299
GH02G084887 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +17.9 17928 3.2 PKNOX1 FOXA2 CREB3L1 YBX1 ZBTB40 RAD21 YY1 RELB ETV6 IKZF2 RPS2P17 TRABD2A TMSB10 LOC105374837 GC02P084898
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRABD2A on UCSC Golden Path with GeneCards custom track

Promoters for TRABD2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119479 575 2001 PKNOX1 ARID4B SIN3A BRCA1 ZNF2 ZNF48 ZNF121 ZNF143 JUNB REST

Genomic Location for TRABD2A Gene

Chromosome:
2
Start:
84,821,650 bp from pter
End:
84,907,008 bp from pter
Size:
85,359 bases
Orientation:
Minus strand

Genomic View for TRABD2A Gene

Genes around TRABD2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2A Gene

Proteins for TRABD2A Gene

  • Protein details for TRABD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V40-TIKI1_HUMAN
    Recommended name:
    Metalloprotease TIKI1
    Protein Accession:
    Q86V40
    Secondary Accessions:
    • B4DKK8
    • I6UMB9

    Protein attributes for TRABD2A Gene

    Size:
    505 amino acids
    Molecular mass:
    57676 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.
    SequenceCaution:
    • Sequence=AAH51789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRABD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRABD2A Gene

Post-translational modifications for TRABD2A Gene

  • Glycosylation at Asn220, posLast=229229, isoforms=2278, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for TRABD2A Gene

No data available for DME Specific Peptides for TRABD2A Gene

Domains & Families for TRABD2A Gene

Protein Domains for TRABD2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRABD2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86V40

UniProtKB/Swiss-Prot:

TIKI1_HUMAN :
  • Belongs to the TIKI family.
Family:
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2A: view

No data available for Gene Families for TRABD2A Gene

Function for TRABD2A Gene

Molecular function for TRABD2A Gene

UniProtKB/Swiss-Prot Function:
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2A Gene

Gene Ontology (GO) - Molecular Function for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 22726442
GO:0004222 metalloendopeptidase activity ISS,IDA 22726442
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TRABD2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD2A Gene

Localization for TRABD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2A Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRABD2A gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IDA 22726442
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IDA 22726442
genes like me logo Genes that share ontologies with TRABD2A: view

Pathways & Interactions for TRABD2A Gene

genes like me logo Genes that share pathways with TRABD2A: view

Pathways by source for TRABD2A Gene

1 R&D Systems pathway for TRABD2A Gene

Interacting Proteins for TRABD2A Gene

Gene Ontology (GO) - Biological Process for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 22726442
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 22726442
GO:0032461 positive regulation of protein oligomerization ISS 22726442
GO:0060322 head development ISS --
genes like me logo Genes that share ontologies with TRABD2A: view

No data available for SIGNOR curated interactions for TRABD2A Gene

Drugs & Compounds for TRABD2A Gene

No Compound Related Data Available

Transcripts for TRABD2A Gene

Unigene Clusters for TRABD2A Gene

TraB domain containing 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:

Relevant External Links for TRABD2A Gene

GeneLoc Exon Structure for
TRABD2A
ECgene alternative splicing isoforms for
TRABD2A

Expression for TRABD2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRABD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2A Gene

This gene is overexpressed in Colon - Transverse (x13.9), Ovary (x10.2), and Whole Blood (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRABD2A Gene



NURSA nuclear receptor signaling pathways regulating expression of TRABD2A Gene:

TRABD2A

SOURCE GeneReport for Unigene cluster for TRABD2A Gene:

Hs.469134

Evidence on tissue expression from TISSUES for TRABD2A Gene

  • Intestine(4.4)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with TRABD2A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRABD2A Gene

Orthologs for TRABD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD2A 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia TRABD2A 34 35
  • 86.04 (n)
oppossum
(Monodelphis domestica)
Mammalia TRABD2A 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRABD2A 34 35
  • 71.56 (n)
lizard
(Anolis carolinensis)
Reptilia TRABD2A 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trabd2a 34
  • 64.35 (n)
zebrafish
(Danio rerio)
Actinopterygii wu:fc66h01 34 35
  • 72.16 (n)
worm
(Caenorhabditis elegans)
Secernentea C05G5.5 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for TRABD2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRABD2A Gene

ENSEMBL:
Gene Tree for TRABD2A (if available)
TreeFam:
Gene Tree for TRABD2A (if available)

Paralogs for TRABD2A Gene

Paralogs for TRABD2A Gene

(1) SIMAP similar genes for TRABD2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRABD2A: view

Variants for TRABD2A Gene

Sequence variations from dbSNP and Humsavar for TRABD2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000007927 -- 84,840,794(+) TCCCT(C/T)TCCTC intron-variant
rs1000010704 -- 84,833,347(+) GAAAA(A/T)AAGTC intron-variant
rs1000044367 -- 84,873,848(+) GAGAT(C/T)TAATT intron-variant
rs1000100003 -- 84,869,242(+) AAACC(C/T)CAACG intron-variant
rs1000190569 -- 84,840,228(+) GCCTC(A/G)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRABD2A Gene

Variant ID Type Subtype PubMed ID
esv2720286 CNV deletion 23290073
esv2720287 CNV deletion 23290073
esv3583913 CNV loss 25503493
esv3591522 CNV loss 21293372
nsv527061 CNV loss 19592680
nsv527911 CNV loss 19592680
nsv961799 CNV duplication 23825009

Variation tolerance for TRABD2A Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.10; 75.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRABD2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRABD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRABD2A Gene

Disorders for TRABD2A Gene

Relevant External Links for TRABD2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRABD2A

No disorders were found for TRABD2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD2A Gene

Publications for TRABD2A Gene

  1. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X. … He X. (Cell 2012) 2 3 4 64
  2. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis A.H. … He X. (Int. J. Dev. Biol. 2014) 2 3 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TRABD2A Gene

Sources for TRABD2A Gene

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