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Aliases for TRABD2A Gene

Aliases for TRABD2A Gene

  • TraB Domain Containing 2A 2 3
  • TIKI1 3 4 6
  • TRAB Domain-Containing Protein 2A 3 4
  • C2orf89 3 4
  • Chromosome 2 Open Reading Frame 89 2
  • UPF0632 Protein C2orf89 3
  • Metalloprotease TIKI1 3
  • EC 3.4.-.- 4

External Ids for TRABD2A Gene

Previous HGNC Symbols for TRABD2A Gene

  • C2orf89

Previous GeneCards Identifiers for TRABD2A Gene

  • GC02M085049

Summaries for TRABD2A Gene

GeneCards Summary for TRABD2A Gene

TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2B.

UniProtKB/Swiss-Prot for TRABD2A Gene

  • Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD2A Gene

Genomics for TRABD2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRABD2A Gene

Start:
84,821,650 bp from pter
End:
84,907,008 bp from pter
Size:
85,359 bases
Orientation:
Minus strand

Genomic View for TRABD2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRABD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD2A Gene

No data available for Regulatory Elements for TRABD2A Gene

Proteins for TRABD2A Gene

  • Protein details for TRABD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86V40-TIKI1_HUMAN
    Recommended name:
    Metalloprotease TIKI1
    Protein Accession:
    Q86V40
    Secondary Accessions:
    • B4DKK8
    • I6UMB9

    Protein attributes for TRABD2A Gene

    Size:
    505 amino acids
    Molecular mass:
    57676 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Divalent metal cations. Mn(2+) or Co(2+).;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Was named TIKI in reference to large-headed humanoid in Polynesian mythology.
    SequenceCaution:
    • Sequence=AAH51789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRABD2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRABD2A Gene

Proteomics data for TRABD2A Gene at MOPED

Post-translational modifications for TRABD2A Gene

  • Glycosylation at Asn220, Asn229, Asn278, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for TRABD2A Gene

No data available for DME Specific Peptides for TRABD2A Gene

Domains for TRABD2A Gene

Protein Domains for TRABD2A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86V40

UniProtKB/Swiss-Prot:

TIKI1_HUMAN :
  • Q86V40
Family:
  • Belongs to the TIKI family.
genes like me logo Genes that share domains with TRABD2A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TRABD2A Gene

Function for TRABD2A Gene

Molecular function for TRABD2A Gene

UniProtKB/Swiss-Prot Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Enzyme Numbers (IUBMB) for TRABD2A Gene

Gene Ontology (GO) - Molecular Function for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IDA 22726442
GO:0017147 Wnt-protein binding IDA 22726442
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRABD2A: view

Phenotypes for TRABD2A Gene

genes like me logo Genes that share phenotypes with TRABD2A: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRABD2A Gene

Localization for TRABD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRABD2A Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 22726442
GO:0031301 integral component of organelle membrane IDA 22726442
genes like me logo Genes that share ontologies with TRABD2A: view

No data available for Subcellular locations from COMPARTMENTS for TRABD2A Gene

Pathways for TRABD2A Gene

SuperPathways for TRABD2A Gene

No Data Available

Interacting Proteins for TRABD2A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335004%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000335004 Q86V40-TIKI1_HUMAN for TRABD2A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TRABD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008152 metabolic process IDA 22726442
GO:0016055 Wnt signaling pathway IEA --
GO:0018158 protein oxidation IDA 22726442
GO:0030178 negative regulation of Wnt signaling pathway IDA 22726442
genes like me logo Genes that share ontologies with TRABD2A: view

No data available for Pathways by source for TRABD2A Gene

Transcripts for TRABD2A Gene

Unigene Clusters for TRABD2A Gene

TraB domain containing 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRABD2A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRABD2A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - -
SP9:

Relevant External Links for TRABD2A Gene

GeneLoc Exon Structure for
TRABD2A
ECgene alternative splicing isoforms for
TRABD2A

Expression for TRABD2A Gene

mRNA expression in normal human tissues for TRABD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD2A Gene

This gene is overexpressed in Colon - Transverse (13.9), Ovary (10.2), and Whole Blood (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRABD2A Gene

SOURCE GeneReport for Unigene cluster for TRABD2A Gene Hs.469134

genes like me logo Genes that share expressions with TRABD2A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRABD2A Gene

Orthologs for TRABD2A Gene

This gene was present in the common ancestor of animals.

Orthologs for TRABD2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD2A 35
  • 99.13 (n)
  • 99.05 (a)
TRABD2A 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRABD2A 35
  • 86.04 (n)
  • 86.11 (a)
TRABD2A 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRABD2A 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRABD2A 35
  • 71.56 (n)
  • 71.9 (a)
TRABD2A 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRABD2A 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trabd2a 35
  • 64.35 (n)
  • 69.12 (a)
zebrafish
(Danio rerio)
Actinopterygii wu:fc66h01 35
  • 72.16 (n)
  • 75.42 (a)
wu:fc66h01 36
  • 51 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C05G5.5 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TRABD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRABD2A Gene

ENSEMBL:
Gene Tree for TRABD2A (if available)
TreeFam:
Gene Tree for TRABD2A (if available)

Paralogs for TRABD2A Gene

Paralogs for TRABD2A Gene

Selected SIMAP similar genes for TRABD2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRABD2A: view

Variants for TRABD2A Gene

Sequence variations from dbSNP and Humsavar for TRABD2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs735797 -- 84,862,290(-) GAACA(C/T)GAATT intron-variant
rs736711 -- 84,839,121(+) TCAGA(A/G)GCTAA intron-variant
rs890616 -- 84,856,554(-) TATCT(C/T)GTCCT intron-variant
rs890617 -- 84,856,379(-) TCACC(G/T)CCTTG intron-variant
rs890618 -- 84,839,750(-) TTTAA(A/G)TGTTT intron-variant

Relevant External Links for TRABD2A Gene

HapMap Linkage Disequilibrium report
TRABD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRABD2A Gene

Disorders for TRABD2A Gene

No disorders were found for TRABD2A Gene.

No data available for UniProtKB/Swiss-Prot for TRABD2A Gene

Publications for TRABD2A Gene

  1. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. (PMID: 22726442) Zhang X. … He X. (Cell 2012) 2 3 4
  2. Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates. (PMID: 25354456) Reis A.H. … He X. (Int. J. Dev. Biol. 2014) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for TRABD2A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRABD2A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRABD2A
    • Block miRNA regulation of TRABD2A using miScript Target Protectors

    Sources for TRABD2A Gene

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