Aliases for TRABD2A Gene
External Ids for TRABD2A Gene
Previous Symbols for TRABD2A Gene
GeneCards Summary for TRABD2A Gene
TRABD2A (TraB Domain Containing 2A) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and Wnt-protein binding. An important paralog of this gene is TRABD2B.
UniProtKB/Swiss-Prot for TRABD2A Gene
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.