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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRABD2A Gene

protein-coding GIFtS: 38
GCID: GC02M085049

TraB domain containing 2A

(Previous name: chromosome 2 open reading frame 89 )
(Previous symbol: C2orf89)

Search for TRABD2A
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TraB Domain Containing 2A¹ ²		Chromosome 2 Open Reading Frame 89¹
C2orf89¹ ² ³		Metalloprotease TIKI1²
TIKI1² ³		UPF0632 Protein C2orf89²
TRAB Domain-Containing Protein 2A² ³		EC 3.4.-.-³

External Ids:	HGNC: 27013¹	Entrez Gene: 129293²	Ensembl: ENSG00000186854⁷	OMIM: 614912⁵	UniProtKB: Q86V40³

Export aliases for TRABD2A gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TIKI1_HUMAN, Q86V40

Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of

the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large

disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head

formation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TRABD2A
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TRABD2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRABD2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

TRABD2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRABD2A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M085049: view genomic region (about GC identifiers)

Start:	85,048,774 bp from pter	End:	85,134,132 bp from pter
Size:	85,359 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIKI1_HUMAN, Q86V40 (See protein sequence)

Recommended Name: Metalloprotease TIKI1 precursor

Size: 505 amino acids; 57676 Da

Cofactor: Divalent metal cations. Manganese or cobalt

Subcellular location: Cell membrane; Single-pass type I membrane protein

Miscellaneous: Was named TIKI in reference to large-headed humanoid in Polynesian mythology (PubMed:22726442)

Sequence caution: Sequence=AAH51789.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B4DKK8 I6UMB9

Alternative splicing: 2 isoforms: Q86V40-1 Q86V40-2

Explore the universe of human proteins at neXtProt for TRABD2A: NX_Q86V40

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86V40

TRABD2A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001074293.1

ENSEMBL proteins:

ENSP00000335004 ENSP00000387183 ENSP00000387075

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IDA	--
GO:0016021	integral to membrane	--	--
GO:0031301	integral to organelle membrane	IDA	--

TRABD2A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRABD2A for domains About GeneDecksing

1 InterPro domain/family:

IPR002816 Pheromone_shutdown_TraB

Graphical View of Domain Structure for InterPro Entry Q86V40

ProtoNet protein and cluster: Q86V40

UniProtKB/Swiss-Prot: TIKI1_HUMAN, Q86V40

Similarity: Belongs to the TIKI family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIKI1_HUMAN, Q86V40

Function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of

the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large

disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head

formation

Enzyme Number (IUBMB): EC 3.4.-.-¹

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In Situ Assay
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Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	IDA	--
GO:0017147	Wnt-protein binding	IDA	--
GO:0046872	metal ion binding	IEA	--

TRABD2A for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TRABD2A:

Decreased viability of wild-ty

Increased S DNA content

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRABD2A

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TRABD2A (Q86V40³ ENSP00000335004⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008152	metabolic process	IDA	--
GO:0016055	Wnt receptor signaling pathway	IEA	--
GO:0018158	protein oxidation	IDA	--
GO:0030178	negative regulation of Wnt receptor signaling pathway	IDA	--

TRABD2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TRABD2A gene:

NM_001080824.1

Unigene Cluster for TRABD2A:

TraB domain containing 2A

Hs.469134 [show with all ESTs]

Unigene Representative Sequence: CR936634

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000335459(uc002sou.4) ENST00000479944 ENST00000496500 ENST00000495990(uc002sov.3 uc010fgc.2)

ENST00000409133 ENST00000460991 ENST00000436322 ENST00000474298 ENST00000489999

ENST00000409520(uc010ysl.2)

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Additional cDNA sequence:

AK128325.1 AK296608.1 AK309615.1 BC049209.1 BC051789.1 BC073808.1 CR936634.1 JQ653415.1

8 DOTS entries:

DT.100691883 DT.442837 DT.86840939 DT.121001488 DT.100679108 DT.100754164 DT.121001471 DT.95151540

24/86 AceView cDNA sequences (see all 86):

CF126350 AW613250 AW239056 AI861979 AI762604 BC049209 BE300677 AA705414

AA699688 AA494450 BF732560 BC073808 BF591332 AA703231 AI984132 AI601144

BE303001 H51769 AI248446 AA253471 AW054893 BM984902 AI200423 BC051789

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TRABD2A (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11a	·	11b
SP1:											-		-		-		-		-		-		-				-		-		-
SP2:											-		-		-								-				-		-		-
SP3:																							-				-		-		-
SP4:																							-				-
SP5:																											-

ECgene alternative splicing isoforms for TRABD2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TRABD2A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRABD2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRABD2A

SOURCE GeneReport for Unigene cluster: Hs.469134

SABiosciences Custom PCR Arrays for TRABD2A

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRABD2A gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TRABD2A¹	TraB domain containing 2A	70.49(n) 69.51(a)		427288 XM_003643049.1 XP_003643097.1
lizard (Anolis carolinensis)	Reptilia	C2orf89⁶	--	61(a)	1 ↔ 1	GL343339.1(153166-216586)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137732177²	--	75.88(n)		137732177
zebrafish (Danio rerio)	Actinopterygii	wu:fc66h01¹	wu:fc66h01	64.82(n) 61.06(a)		564021 XM_687381.5 XP_692473.5
worm (Caenorhabditis elegans)	Secernentea	C05G5.5⁶	UPF0632 protein C05G5.5	23(a)	1 → many	X(14756006-14760894)

ENSEMBL Gene Tree for TRABD2A (if available)
TreeFam Gene Tree for TRABD2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRABD2A gene

TRABD2B²

1 SIMAP similar gene for TRABD2A using alignment to 2 protein entries: TIKI1_HUMAN (see all proteins):

TRABD2B

TRABD2A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183672036^1,2		--	85048331(+)	`AGACAC/TTGACA`	1	--	int¹		0	--	--	--	--
rs143265333^1,2	C,	--	85048392(+)	`ACCAC-/TTTTCT`	1	--	int¹		0	--	--	--	--
rs55923408^1,2	C,	--	85048512(+)	`ACAGGG/AAGCAC`	1	--	int¹		2		WA	120
rs59922171^1,2	F,	--	85048756(+)	`TATATA/GTATCA`	1	--	int¹		1		WA	118
rs13023615^1,2	H	--	85048798(+)	`ATTTTC/TATACA`	1	--	ut3¹		4		NS EA	420
rs13000269^1,2	C,H	--	85048841(+)	`TATGTT/CACAAA`	1	--	ut3¹ ese³		4		NS EA	418
rs13024201^1,2	C,H	--	85048935(+)	`GAGCAG/CTCTCT`	1	--	ut3¹ ese³		4		NS EA	418
rs188546476^1,2		--	85048982(+)	`GAGTAC/TAGGAA`	1	--	ut3¹		0	--	--	--	--
rs200837426^1,2		--	85049005(+)	`AAGTCC/TGAGGG`	1	--	ut3¹		0	--	--	--	--
rs76277344^1,2	C,,	--	85049154(+)	`CCCACA/GGCGAG`	2	R C	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRABD2A (85048774 - 85134132 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRABD2A: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for TRABD2A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRABD2A for disorders About MalaCards

TRABD2A for disorders About GeneDecksing

OMIM gene information: 614912 OMIM disorders: --

Export disorders for TRABD2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRABD2A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRABD2A)

Utopia: connect your pdf to the dynamic
world of online information

Tiki1 is required for head formation via Wnt cleavage- oxidation and inactivation. (PubMed id 22726442)^{1, 2} Zhang X....He X. (2012)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 129293	HGNC: 27013	AceView: LOC129293	Ensembl:ENSG00000186854	euGenes: HUgn129293
ECgene: TRABD2A	H-InvDB: TRABD2A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRABD2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRABD2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRABD2A gene:
Search GeneIP for patents involving TRABD2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for TRABD2A
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRABD2A
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	GenScript Custom Purified and Recombinant Proteins Services for TRABD2A		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TRABD2A
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TRABD2A Gene

TraB domain containing 2A

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TRABD2A Gene

TraB domain containing 2A

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