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Aliases for TRABD Gene

Aliases for TRABD Gene

  • TraB Domain Containing 2 3 5
  • TraB Domain-Containing Protein 3
  • Protein TTG2 4
  • LP6054 3
  • PP2447 3
  • TTG2 4

External Ids for TRABD Gene

Previous GeneCards Identifiers for TRABD Gene

  • GC22P048966
  • GC22P050624
  • GC22P033529

Summaries for TRABD Gene

GeneCards Summary for TRABD Gene

TRABD (TraB Domain Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRABD Gene

Genomics for TRABD Gene

Regulatory Elements for TRABD Gene

Enhancers for TRABD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G050183 1.6 FANTOM5 ENCODE dbSUPER 20.1 -0.1 -82 3.9 ATF1 ARID4B DMAP1 ZNF2 ZNF48 YY1 ZNF121 GTF3C2 GLIS2 ZNF143 TRABD LOC105373095 SELENOO ZBED4 ALG12 ENSG00000273253 ENSG00000273192 ENSG00000272836 LOC100420885 PANX2
GH22G050188 1.8 FANTOM5 ENCODE dbSUPER 12.1 +5.2 5175 5.6 HDGF PKNOX1 AGO1 SIN3A ARID4B YBX1 ZNF2 ZNF766 KLF13 ZNF263 TUBGCP6 ENSG00000272836 ZBED4 LOC105373095 MAPK12 ALG12 HDAC10 ENSG00000273253 MAPK11 PLXNB2
GH22G049942 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -236.7 -236664 13.5 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 TUBGCP6 ALG12 ENSG00000272836 DENND6B ZBED4 ENSG00000273192 LOC105373095 PIM3 PANX2 TRABD
GH22G049957 1.4 ENCODE dbSUPER 11.2 -222.8 -222849 11.7 HDGF PKNOX1 FOXA2 MLX ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ALG12 ZBED4 ENSG00000273192 LOC105373095 TRABD ENSG00000272836 PIM3 DENND6B LOC100420885 ENSG00000273253
GH22G050204 1.3 Ensembl ENCODE dbSUPER 10.5 +19.2 19175 1.4 TAF1 KLF17 MAX RAD21 YY1 ZNF791 ZBTB48 HNF4G NFE2 ZNF600 ALG12 SELENOO ENSG00000273192 TRABD SHANK3 HDAC10 PANX2 ENSG00000272836
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRABD on UCSC Golden Path with GeneCards custom track

Promoters for TRABD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000147690 295 1601 TBL1XR1 RB1 ZNF76 ZNF2 ZNF48 ZNF121 GTF3C2 GLIS2 EGR1 ZNF143

Genomic Location for TRABD Gene

Chromosome:
22
Start:
50,185,905 bp from pter
End:
50,199,598 bp from pter
Size:
13,694 bases
Orientation:
Plus strand

Genomic View for TRABD Gene

Genes around TRABD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRABD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRABD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRABD Gene

Proteins for TRABD Gene

  • Protein details for TRABD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4I3-TRABD_HUMAN
    Recommended name:
    TraB domain-containing protein
    Protein Accession:
    Q9H4I3
    Secondary Accessions:
    • Q19CC5
    • Q96ED8
    • Q9H7N1
    • Q9UGX6
    • Q9UGX7

    Protein attributes for TRABD Gene

    Size:
    376 amino acids
    Molecular mass:
    42321 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15737.1; Type=Frameshift; Positions=224, 282; Evidence={ECO:0000305};

    Alternative splice isoforms for TRABD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRABD Gene

Post-translational modifications for TRABD Gene

  • Ubiquitination at isoforms=50, Lys116, and posLast=209209
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRABD Gene

Domains & Families for TRABD Gene

Protein Domains for TRABD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TRABD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRABD: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TRABD Gene

Function for TRABD Gene

genes like me logo Genes that share phenotypes with TRABD: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRABD

CRISPR Products

miRNA for TRABD Gene

miRTarBase miRNAs that target TRABD

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRABD Gene

Localization for TRABD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRABD gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRABD Gene

Pathways & Interactions for TRABD Gene

SuperPathways for TRABD Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRABD Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRABD Gene

Drugs & Compounds for TRABD Gene

No Compound Related Data Available

Transcripts for TRABD Gene

Unigene Clusters for TRABD Gene

TraB domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRABD Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: - -
SP10: - - - -
SP11: -
SP12: -
SP13: -
SP14:

ExUns: 11c · 11d · 11e ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - - -
SP12:
SP13:
SP14:

Relevant External Links for TRABD Gene

GeneLoc Exon Structure for
TRABD
ECgene alternative splicing isoforms for
TRABD

Expression for TRABD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRABD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRABD Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for TRABD Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.8), Breast (17.8), and Bone (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRABD Gene



Protein tissue co-expression partners for TRABD Gene

NURSA nuclear receptor signaling pathways regulating expression of TRABD Gene:

TRABD

SOURCE GeneReport for Unigene cluster for TRABD Gene:

Hs.517731

Evidence on tissue expression from TISSUES for TRABD Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with TRABD: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRABD Gene

Orthologs for TRABD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRABD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRABD 34 35
  • 94.29 (n)
dog
(Canis familiaris)
Mammalia TRABD 34 35
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia TRABD 34 35
  • 88.21 (n)
rat
(Rattus norvegicus)
Mammalia Trabd 34
  • 86.86 (n)
mouse
(Mus musculus)
Mammalia Trabd 34 16 35
  • 86.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TRABD 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRABD 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRABD 34 35
  • 68.55 (n)
lizard
(Anolis carolinensis)
Reptilia TRABD 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trabd 34
  • 67.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32087 34
zebrafish
(Danio rerio)
Actinopterygii trabd 34 35
  • 68.07 (n)
Dr.26717 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004340 34
  • 57.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12360 34 35
  • 56.92 (n)
worm
(Caenorhabditis elegans)
Secernentea F38A5.2 35
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05270 34
  • 46.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8533 35
  • 40 (a)
OneToOne
Species where no ortholog for TRABD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRABD Gene

ENSEMBL:
Gene Tree for TRABD (if available)
TreeFam:
Gene Tree for TRABD (if available)

Paralogs for TRABD Gene

No data available for Paralogs for TRABD Gene

Variants for TRABD Gene

Sequence variations from dbSNP and Humsavar for TRABD Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000104568 -- 50,189,443(+) GGAGA(A/G)TGAAG intron-variant, upstream-variant-2KB
rs1000107044 -- 50,190,637(+) GGTCC(A/G)GACTT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000184359 -- 50,187,381(+) GCCAG(C/G)CATCA intron-variant
rs1000249865 -- 50,196,287(+) AGTTA(-/GCCTGGGCTCCCCAGGGTG)GCCTG intron-variant
rs1000429509 -- 50,196,420(+) CGCTG(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRABD Gene

Variant ID Type Subtype PubMed ID
dgv781n67 CNV gain 20364138
esv2724755 CNV deletion 23290073
esv2724756 CNV deletion 23290073
esv2724757 CNV deletion 23290073
nsv191327 CNV deletion 16902084
nsv471223 CNV loss 18288195
nsv829333 CNV gain 20364138
nsv955199 CNV deletion 24416366

Variation tolerance for TRABD Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRABD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRABD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRABD Gene

Disorders for TRABD Gene

Relevant External Links for TRABD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRABD

No disorders were found for TRABD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRABD Gene

Publications for TRABD Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PMID: 12529303) Collins J.E. … Dunham I. (Genome Res. 2003) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64

Products for TRABD Gene

Sources for TRABD Gene

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