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Aliases & Descriptions for TRA@
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ22602 2 MGC117436 2 MGC22624 2 MGC23964 2 MGC71411 2 TCRA 2 TCRD 2 TRA 1 , 2
Descriptions T cell receptor alpha locus 2 T-cell antigen receptor, alpha polypeptide 2 T-cell receptor, alpha (V,D,J,C) 2
Search outside databases for aliases for TRA@ genePrevious GC identifers: GC14U990056 GC14P020456
Summaries for TRA@ (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for TRA@
Genomic Location for TRA@
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2 TRA@ Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P021160:
(about GC identifiers )
Start:
21,159,897 bp from pter
End:
22,090,915 bp from pter
Size:
931,019 bases
Orientation:
plus strand
1 alternative location : Chr 14+ 22,001,764-22,003,154
Proteins for TRA@
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TCA_HUMAN, P01848 (See
protein sequence )Recommended Name: T-cell receptor alpha chain C region Size : 142 amino acids; 15928 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)
Miscellaneous : This clone was isolated from a human leukemic T-cell line, Jurkat
Miscellaneous : This alpha chain C region shows sequence homology to its beta chain counterpart
Miscellaneous : The gene corresponding to this mRNA is rearranged specifically in T-cells; itsorganization is similar to an Ig gene, with V, D, J, and C regions
PDB structures from and Proteopedia : 1KGC (3D)
 1MI5 (3D)
 1OGA (3D)
 1QRN (3D)
 1YMM (3D)
 1ZGL (3D)
 2AK4 (3D)
 2BNQ (3D)
 2BNR (3D)
 2BNU (3D)
 2ESV (3D)
 2EYR (3D)
 2EYS (3D)
 2EYT (3D)
 2F53 (3D)
 2F54 (3D)
 2GJ6 (3D)
 2IAL (3D)
 2IAM (3D)
 2IAN (3D)
 2P5E (3D)
 2P5W (3D)
 2PO6 (3D)
 2PYE (3D)
 2PYF (3D)
 2VLJ (3D)
 2VLK (3D)
 2VLM (3D)
 2VLR (3D)
 3DX9 (3D)
 3DXA (3D)
 3FFC (3D)
 
ENSEMBL proteins: ENSP00000374979 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TRA@: Assays for TRA@:
Protein
Domains/ Families for TRA@(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P01848 ProtoNet protein and cluster: P01848
Gene Function for TRA@
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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                 Browse Origene for 29mer shRNA kit in GFP-retroviral vector Applied Biosystems Silencer ® siRNAs for TRA@ Browse siRNA at Sigma-Aldrich Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs                OriGene untagged cDNA clones in CMV expression vector (see all 4 ): BC020840  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers                  Browse Origene genome-wide validated SYBR primer pairs 4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for TRA@
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/51 Interacting proteins for TRA@ (P01848 1 , 2 ENSP00000374979 3 ) via UniProtKB, MINT, and/or STRING (see all 51
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006968 cellular defense response
NAS --
About this table
Drugs & Compounds for TRA@ (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TRA@ 2 Novoseek chemical compound relationships for TRA@ gene
About this table 2 PharmGKB drug compound relationships for TRA@ gene About this table
Transcripts for TRA@(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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                 Browse Origene for 29mer shRNA kit in GFP-retroviral vector Browse siRNA at Sigma-Aldrich Browse shRNA at Sigma-Aldrich Explore Sigma-Aldrich super-pooled esiRNAs                OriGene untagged cDNA clones in CMV expression vector (see all 4 ): BC020840  
highest scoring ESTs for TRA@ :L02424 AF018170 AW802679 AW869039 BX377056 BX643584 CD707476 DA074328 DB115704 DB165292 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000390537
Expression for TRA@
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TRA@ expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TRA@ 1 / 2 / 3
27 probe-sets matching TRA@ gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --Expression variation in blood from EXPOLDB for TRA@
Orthologs for TRA@
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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ENSEMBL Gene Tree for TRA@ Paralogs for TRA@ (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for TRA@ (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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Disorders & Mutations for TRA@
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 186880 10/15 Novoseek disease relationships for TRA@ gene (see all 15
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
t-all
54.39
12
10361104 (3), 15668700 (2)
colitis ulcerative
33.15
3
7821111 (1), 1971608 (1), 8760824 (1)
multiple sclerosis
30.15
6
1346471 (1), 1387654 (1), 7931419 (1), 1348852 (1) (see all 6 )
diabetes mellitus insulin-dependent
20.06
1
9098400 (1)
lupus nephritis
13.81
1
9746855 (1)
rheumatoid arthritis
10.64
1
9002046 (1)
inflammatory bowel diseases
9.20
2
8760824 (1), 8642289 (1)
chromosomal aberrations
5.72
1
15668700 (1)
lymphoma
2.16
2
8279454 (1), 1853936 (1)
leukemia
0.45
4
1648373 (1), 11054065 (1), 1569404 (1)
About this table 1 PharmGKB disease relationship for TRA@ gene About this table Genetic Association Database: TRA@ Human Genome Epidemiology Navigator: TRA@ (1 document)
Medical News for TRA@ (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TRA@ (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/181 PubMed articles for TRA@ gene (see all 181
): A structural basis for immunodominant human T cell receptor recognition. (PubMed id 12796775) 3, 4 Stewart-Jones G.B.E....Jones E.Y. (2003) The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. (PubMed id 12429093) 3, 4 Kjer-Nielsen L.... Rossjohn J. (2002) Association study of proposed candidate genes/regions in a population of Spanish asthmatics. (PubMed id 11142503) 3, 6 Soriano J.B....Lazaro C. (2000) The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. (PubMed id 3875483) 2, 3 Rabbitts T.H....Goodfellow P.N. (1985) Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. (PubMed id 3873654) 3, 4 Yanagi Y.... Mak T.W. (1985) Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias. (PubMed id 3875152) 2, 3 Erikson J....Croce C.M. (1985) Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP. (PubMed id 1649196) 1, 3 Suzuki C.K....Klausner R.D. (1991) Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes. (PubMed id 17015149) 1, 3 Touvrey C....Candeias S.M. (2006) T-cell receptor alpha, beta, gamma, and delta chain gene microsatellites show no association with multiple sclerosis. (PubMed id 8857743) 1, 6 Droogan A.G....Graham C.A. (1996) The T cell antigen receptor alpha and beta chains interact via distinct regions with CD3 chains. (PubMed id 8020575) 1, 3 Manolios N....Li Z.G. (1994)
Search for TRA@
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Genome Databases showing TRA@
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TRA@
(According to HUGE )
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Specialized Databases showing TRA@ (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
ATLAS Chromosomes in Cancer entry for TRA@ Genetics and Cytogenetics in Oncology and Haematology IMGT entry for TRA@ The international I mM unoG eneT ics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.
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-- Services for TRA@ (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for TRA@:
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