Aliases for TRA2B Gene
Aliases for TRA2B Gene
External Ids for TRA2B Gene
- HGNC: 10781
- Entrez Gene: 6434
- Ensembl: ENSG00000136527
- OMIM: 602719
- UniProtKB: P62995
Previous HGNC Symbols for TRA2B Gene
- SFRS10
Previous GeneCards Identifiers for TRA2B Gene
- GC03M187110
- GC03M185632
- GC03M183042
Summaries for TRA2B Gene
-
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRA2B Gene
TRA2B (Transformer 2 Beta Homolog) is a Protein Coding gene. Diseases associated with TRA2B include Frontotemporal Dementia. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRA2A.
UniProtKB/Swiss-Prot for TRA2B Gene
-
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRA2B Gene
Genomics for TRA2B Gene
GeneHancer (GH) Regulatory Elements for TRA2B Gene
Promoters and enhancers for TRA2B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TRA2B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TRA2B gene promoter:
Regulatory Element Products
Genomic Locations for TRA2B Gene
Genomic Locations for TRA2B Gene
- chr3:185,914,568-185,938,136
- (GRCh38/hg38)
- Size:
- 23,569 bases
- Orientation:
- Minus strand
- chr3:185,632,356-185,655,924
- (GRCh37/hg19)
Genomic View for TRA2B Gene
Genes around TRA2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q27.2 by Ensembl
- 3q27.2 by Entrez Gene
- 3q27.2 by HGNC
TRA2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRA2B Gene
Proteins for TRA2B Gene
-
Protein details for TRA2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62995-TRA2B_HUMAN
- Recommended name:
- Transformer-2 protein homolog beta
- Protein Accession:
- P62995
- B4DVK2
- D3DNU3
- O15449
- Q15815
- Q64283
Protein attributes for TRA2B Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33666 Da
- Quaternary structure:
-
- Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A.
Three dimensional structures from OCA and Proteopedia for TRA2B Gene
Alternative splice isoforms for TRA2B Gene
- UniProtKB/Swiss-Prot:
Protein Expression for TRA2B Gene
Post-translational modifications for TRA2B Gene
- Dimethylation at Arg-241 is probably asymmetric.
- Phosphorylated in the RS domains.
- Ubiquitination at isoforms=3140 and posLast=197197
Other Protein References for TRA2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TRA2B
- Novus Biologicals Antibodies for TRA2B
-
Abcam antibodies for TRA2B
-
Cloud-Clone Corp. Antibodies for TRA2B
- Invitrogen Antibodies for TRA2B
- GeneTex TRA2B antibody for TRA2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRA2B
Protein Products
-
OriGene Purified Proteins for TRA2B
- Search Origene for MassSpec and Protein Over-expression Lysates for TRA2B
- Origene Custom Protein Services for TRA2B
-
Cloud-Clone Corp. Proteins for TRA2B
- antibodies-online: Search results for 8 available TRA2B Proteins ranked by validation data
- Compare Top TRA2B Proteins
-
Quality Products:
- Search GeneTex for Proteins for TRA2B
-
Abcam proteins for TRA2B
Assay Products
-
Cloud-Clone Corp. Assay Kits for TRA2B
- antibodies-online: Search results for 1 available TRA2B Elisa Kits ranked by validation data
- Compare Top TRA2B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TRA2B Gene
Domains & Families for TRA2B Gene
Gene Families for TRA2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for TRA2B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TRA2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P62995- Family:
-
- Belongs to the splicing factor SR family.
Function for TRA2B Gene
Molecular function for TRA2B Gene
- UniProtKB/Swiss-Prot Function:
- Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
Phenotypes From GWAS Catalog for TRA2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IMP | 10749975 |
| GO:0003729 | mRNA binding | IDA | 12165565 |
| GO:0005515 | protein binding | IPI | 10749975 |
| GO:0019904 | protein domain specific binding | IPI | 10749975 |
Phenotypes for TRA2B Gene
- MGI mutant phenotypes for TRA2B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TRA2B:
Animal Models for TRA2B Gene
- MGI Knock Outs for TRA2B:
-
- Tra2b tm1.2Bwir
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for TRA2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRA2B gene
- Search ViGene Biosciences for TRA2B
CRISPR Products
-
OriGene CRISPR knockouts for TRA2B
- genomics-online: gRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- Applied Biological Materials CRISPR for TRA2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRA2B
- GenScript: Design CRISPR guide RNA sequences for TRA2B
miRNA for TRA2B Gene
- miRTarBase miRNAs that target TRA2B
-
- hsa-mir-10a-5p (MIRT006537)
- hsa-mir-10b-5p (MIRT006538)
- hsa-mir-1-3p (MIRT024099)
- hsa-mir-378a-3p (MIRT043884)
- hsa-mir-30c-5p (MIRT047840)
- hsa-mir-196a-5p (MIRT048194)
- hsa-mir-17-5p (MIRT050923)
- hsa-let-7c-3p (MIRT355011)
- hsa-mir-3591-5p (MIRT444559)
- hsa-mir-921 (MIRT444560)
- hsa-mir-3606-5p (MIRT444561)
- hsa-mir-145-3p (MIRT444562)
- hsa-mir-27b-5p (MIRT444563)
- hsa-mir-539-5p (MIRT444564)
- hsa-mir-3174 (MIRT444565)
- hsa-mir-590-3p (MIRT444566)
- hsa-mir-4282 (MIRT444567)
- hsa-mir-190b (MIRT520515)
- hsa-mir-190a-5p (MIRT520516)
- hsa-mir-559 (MIRT520517)
- hsa-mir-548y (MIRT520518)
- hsa-mir-548w (MIRT520519)
- hsa-mir-548o-5p (MIRT520520)
- hsa-mir-548j-5p (MIRT520521)
- hsa-mir-548i (MIRT520522)
- hsa-mir-548h-5p (MIRT520523)
- hsa-mir-548d-5p (MIRT520524)
- hsa-mir-548c-5p (MIRT520525)
- hsa-mir-548bb-5p (MIRT520526)
- hsa-mir-548b-5p (MIRT520527)
- hsa-mir-548ay-5p (MIRT520528)
- hsa-mir-548au-5p (MIRT520529)
- hsa-mir-548as-5p (MIRT520530)
- hsa-mir-548ar-5p (MIRT520531)
- hsa-mir-548aq-5p (MIRT520532)
- hsa-mir-548ap-5p (MIRT520533)
- hsa-mir-548am-5p (MIRT520534)
- hsa-mir-548ak (MIRT520535)
- hsa-mir-548ae-5p (MIRT520536)
- hsa-mir-548ad-5p (MIRT520537)
- hsa-mir-548ab (MIRT520538)
- hsa-mir-548a-5p (MIRT520539)
- hsa-mir-548n (MIRT520540)
- hsa-mir-548c-3p (MIRT520541)
- hsa-mir-493-5p (MIRT565242)
- hsa-let-7g-3p (MIRT565243)
- hsa-let-7a-2-3p (MIRT565244)
- hsa-mir-4670-3p (MIRT565245)
- hsa-mir-338-5p (MIRT565246)
- hsa-mir-1252-3p (MIRT565247)
- hsa-mir-3646 (MIRT565248)
- hsa-mir-548z (MIRT565249)
- hsa-mir-548h-3p (MIRT565250)
- hsa-mir-548d-3p (MIRT565251)
- hsa-mir-548bb-3p (MIRT565252)
- hsa-mir-548ac (MIRT565253)
- hsa-mir-362-3p (MIRT609594)
- hsa-mir-329-3p (MIRT609595)
- hsa-mir-8485 (MIRT609596)
- hsa-mir-497-3p (MIRT613533)
- hsa-mir-548t-3p (MIRT613534)
- hsa-mir-548ap-3p (MIRT613535)
- hsa-mir-548aa (MIRT613536)
- hsa-mir-3613-3p (MIRT652240)
- hsa-mir-6818-3p (MIRT707132)
- hsa-mir-4684-5p (MIRT707133)
- hsa-mir-6715b-3p (MIRT707134)
- hsa-mir-593-3p (MIRT707135)
- hsa-mir-6895-3p (MIRT707136)
- hsa-mir-5699-3p (MIRT707137)
- hsa-mir-4421 (MIRT707138)
- hsa-mir-339-5p (MIRT707139)
- hsa-mir-6715a-3p (MIRT707140)
- hsa-mir-6732-3p (MIRT707141)
miRNA Products
- Search ViGene Biosciences for TRA2B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRA2B
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- genomics-online: shRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRA2B gene
Clone Products
- Sino Biological Human cDNA Clone for TRA2B
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- Applied Biological Materials Clones for TRA2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TRA2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TRA2B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TRA2B gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRA2B Gene
Localization for TRA2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRA2B Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 9546399 |
| GO:0005637 | nuclear inner membrane | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IMP | 25689357 |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for TRA2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.50
.41
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for TRA2B Gene
1 BioSystems pathway for TRA2B Gene
4 Reactome pathways for TRA2B Gene
1 KEGG pathway for TRA2B Gene
Interacting Proteins for TRA2B Gene
Selected Interacting proteins:
P62995-TRA2B_HUMAN
ENSP00000416959
for TRA2B Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000302 | response to reactive oxygen species | IEA | -- |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | 9546399 |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | IMP | 25689357 |
| GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
No data available for SIGNOR curated interactions for TRA2B Gene
Transcripts for TRA2B Gene
mRNA/cDNA for TRA2B Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (562) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TRA2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for TRA2B
- genomics-online: gRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- Applied Biological Materials CRISPR for TRA2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRA2B
- GenScript: Design CRISPR guide RNA sequences for TRA2B
miRNA Products
- Search ViGene Biosciences for TRA2B
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TRA2B
- Browse OriGene Inhibitory RNA Products For TRA2B
- genomics-online: shRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TRA2B gene
Clone Products
- Sino Biological Human cDNA Clone for TRA2B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for TRA2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Expression for TRA2B Gene
This gene is overexpressed in Peripheral blood mononuclear cells (8.1), Fetal Brain (6.4), and Fetal ovary (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRA2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TRA2B Gene:
TRA2BSOURCE GeneReport for Unigene cluster for TRA2B Gene:
Hs.533122mRNA Expression by UniProt/SwissProt for TRA2B Gene:
P62995-TRA2B_HUMAN
Tissue specificity:
Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver.
Evidence on tissue expression from TISSUES for TRA2B Gene
- Nervous system(4.9)
- Lung(4.6)
- Skin(4.6)
- Spleen(4.4)
- Intestine(3.1)
- Kidney(2.4)
- Bone marrow(2.3)
- Eye(2.2)
Primer Products
-
OriGene qPCR primer pairs for TRA2B
-
OriGene qPCR primer pairs and template standards for TRA2B
- genomics-online: primer clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRA2B Gene
Orthologs for TRA2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TRA2B 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | TRA2B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TRA2B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TRA2B 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tra2b 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tra2b 33 |
|
||
| chicken (Gallus gallus) |
Aves | TRA2B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TRA2B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tra2b 33 |
|
||
| Str.7343 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398448 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tra2b 34 |
|
OneToOne | |
| zgc56612 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | tra2 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | rsp-8 34 |
|
OneToMany |
- Species where no ortholog for TRA2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TRA2B Gene
Paralogs for TRA2B Gene
(6) SIMAP similar genes for TRA2B Gene using alignment to 3 proteins:
Variants for TRA2B Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040289 | -- | 185,933,652(-) | T/TT | genic_upstream_transcript_variant, intron_variant | |
| rs1000052374 | -- | 185,922,002(-) | T/C | intron_variant | |
| rs1000102064 | -- | 185,916,941(-) | T/C | 3_prime_UTR_variant | |
| rs1000155967 | -- | 185,916,675(-) | G/A/T | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1000239069 | -- | 185,915,296(-) | A/G | 3_prime_UTR_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660289 | CNV | deletion | 23128226 |
| esv3598980 | CNV | gain | 21293372 |
| esv3598981 | CNV | loss | 21293372 |
| nsv1142591 | CNV | deletion | 24896259 |
| nsv461035 | CNV | loss | 19166990 |
| nsv592705 | CNV | loss | 21841781 |
| nsv950022 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.28% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRA2B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRA2B Gene
Disorders for TRA2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| frontotemporal dementia |
|
|
Search TRA2B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TRA2B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TRA2B Gene
Publications for TRA2B Gene
- Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. (PMID: 9790768) Nayler O … Stamm S (Genomics 1998) 2 3 4 22 58
- Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E … Mayeda A (Molecular and cellular biology 2004) 3 4 22 58
- Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. (PMID: 9212162) Beil B … Stamm S (DNA and cell biology 1997) 3 4 22 58
- Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks CE … Murray A (Nature genetics 2010) 3 44 58
- Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. (PMID: 19282290) Heinrich B … Stamm S (The Journal of biological chemistry 2009) 3 4 58
Products for TRA2B Gene
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for TRA2B
- Browse OriGene ELISA Kits
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- Origene Custom Protein Services for TRA2B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRA2B
- Browse OriGene Inhibitory RNA Products For TRA2B
- OriGene qPCR primer pairs and template standards for TRA2B
- OriGene qPCR primer pairs for TRA2B
- OriGene CRISPR knockouts for TRA2B
- OriGene ORF clones in human for TRA2B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRA2B
- GenScript: Next-day shipping of latest version cDNA ORF clones for TRA2B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TRA2B
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- GenScript Custom overexpressing Cell Line Services for TRA2B
- GenScript: Design CRISPR guide RNA sequences for TRA2B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TRA2B
- Sino Biological Human cDNA Clone for TRA2B
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
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- Browse Sino Biological ELISA Kits
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- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TRA2B
- Novus Biologicals proteins and lysates for TRA2B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for TRA2B
- Abcam proteins for TRA2B
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for TRA2B
- Cloud-Clone Corp. Proteins for TRA2B
- Cloud-Clone Corp. Assay Kits for TRA2B
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TRA2B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 52 available TRA2B Antibodies ranked by validation data
- Compare Top TRA2B Antibodies
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- antibodies-online: Search results for 1 available TRA2B Elisa Kits ranked by validation data
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- antibodies-online: Search results for 8 available TRA2B Proteins ranked by validation data
- Compare Top TRA2B Proteins
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- GeneTex TRA2B antibody for TRA2B
- Search GeneTex for Proteins for TRA2B
- ViGene Biosciences adenoviral particle packaged cDNA for TRA2B gene
- ViGene Biosciences lentiviral particle packaged cDNA for TRA2B gene
- ViGene Biosciences ready-to-package AAV shRNAs for TRA2B gene
- Search ViGene Biosciences for TRA2B
- Santa Cruz Biotechnology (SCBT) Antibodies for TRA2B
- Search Santa Cruz Biotechnology (SCBT) for TRA2B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRA2B
- genomics-online: cdna clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- orf clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- genomics-online: gRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- genomics-online: primer clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
- genomics-online: shRNA clones - Search results for 116 available TRA2B gene related products
- Overview of 116 available TRA2B gene related products
Sources for TRA2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew