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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRA2B Gene

protein-coding   GIFtS: 55
GCID: GC03M185632

Transformer 2 Beta Homolog (Drosophila)

(Previous names: splicing factor, arginine/serine-rich 10 (transformer 2...)
(Previous symbol: SFRS10)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transformer 2 Beta Homolog (Drosophila)1 2     TRA2-BETA2
SFRS101 2 3     TRAN2B2
Splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog,
Drosophila)1 2
     Transformer-2 Protein Homolog Beta2
Transformer-2 Protein Homolog B2 3     TRA2-beta3
TRA-2 Beta2 3     hTRA2-beta3
SRFS102 5     Splicing Factor, Arginine/Serine-Rich 103
Htra2-beta2     

External Ids:    HGNC: 107811   Entrez Gene: 64342   Ensembl: ENSG000001365277   OMIM: 6027195   UniProtKB: P629953   

Export aliases for TRA2B gene to outside databases

Previous GC identifers: GC03M187110 GC03M183042


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRA2B Gene:
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which
plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for TRA2B Gene: 
TRA2B (transformer 2 beta homolog (Drosophila)) is a protein-coding gene. Diseases associated with TRA2B include tauopathy, and frontotemporal dementia, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include mRNA binding and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995
Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either
activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor
neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the
effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to
pre-mRNA

Gene Wiki entry for TRA2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRA2B gene promoter:
         HFH-3   p53   ATF-2   Bach2   CUTL1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   FOXI1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRA2B promoter sequence
   Search SABiosciences Chromatin IP Primers for TRA2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-q27   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q26.2-q27

TRA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRA2B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M185632:  view genomic region     (about GC identifiers)

Start:
185,632,356 bp from pter      End:
185,655,924 bp from pter
Size:
23,569 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995 (See protein sequence)
Recommended Name: Transformer-2 protein homolog beta  
Size: 288 amino acids; 33666 Da
Subunit: Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex
with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9.
Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A
Subcellular location: Nucleus
4 PDB 3D structures from and Proteopedia for TRA2B:
2CQC (3D)        2KXN (3D)        2RRA (3D)        2RRB (3D)    
Secondary accessions: B4DVK2 D3DNU3 O15449 Q15815 Q64283
Alternative splicing: 3 isoforms:  P62995-1, Q15815-1   P62995-2, Q15815-2   P62995-3, Q15815-3   

Explore the universe of human proteins at neXtProt for TRA2B: NX_P62995

Explore proteomics data for TRA2B at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in the RS domains
  • UniProtKB: Dimethylation at Arg-241 is probably asymmetric
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62995

  • TRA2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRA2B Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230808.1  NP_004584.1  

    ENSEMBL proteins: 
     ENSP00000416959   ENSP00000259043   ENSP00000406561   ENSP00000416887   ENSP00000371626  
     ENSP00000343857  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9546399

    TRA2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P62995

    ProtoNet protein and cluster: P62995

    UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TRA2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRA2B_HUMAN, P62995
    Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either
    activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor
    neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the
    effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to
    pre-mRNA

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003729mRNA binding IDA12165565
    GO:0005515protein binding IPI10749975
         
    TRA2B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tra2b):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     normal 

    TRA2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tra2btm1.2Bwir for TRA2B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRA2B 
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    SwitchGear 3'UTR luciferase reporter plasmidTRA2B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TRA2B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TRA2B
        mRNA processing


    1         Kegg Pathway  (Kegg details for TRA2B):
        Spliceosome


    TRA2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/72 Interacting proteins for TRA2B (P629952, 3 ENSP000004169594) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205773 I2D: score=1 STRING: ENSP00000221494
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species IEA--
    GO:0000375RNA splicing, via transesterification reactions TAS9546399
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA12165565
    GO:0000398mRNA splicing, via spliceosome IDA9546399
    GO:0048026positive regulation of mRNA splicing, via spliceosome IDA15009664

    TRA2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRA2B

    Search CenterWatch for drugs/clinical trials and news about TRA2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRA2B gene (2 alternative transcripts): 
    NM_001243879.1  NM_004593.2  

    Unigene Cluster for TRA2B:

    Transformer 2 beta homolog (Drosophila)
    Hs.533122  [show with all ESTs]
    Unigene Representative Sequence: AB209208
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000453386(uc010hym.3 uc003fpv.3) ENST00000492417 ENST00000463328(uc003fpt.3)
    ENST00000259043 ENST00000414862 ENST00000466832 ENST00000487615(uc003fpu.3)
    ENST00000456380(uc003fpx.2) ENST00000382191 ENST00000465245 ENST00000485530
    ENST00000493864 ENST00000477939 ENST00000471134 ENST00000480461 ENST00000342294


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    Additional mRNA sequence: 

    AB209208.1 AK091863.1 AK094495.1 AK098191.1 AK125610.1 AK301118.1 AK308267.1 AK315632.1 
    BC000160.2 BC000451.2 BC005898.1 CR749214.1 U61267.1 U68063.1 U87836.1 

    24/35 DOTS entries (see all 35):

    DT.91761815  DT.92360269  DT.100730598  DT.95233361  DT.100878524  DT.91761814  DT.100878535  DT.100878527 
    DT.97860426  DT.120855947  DT.100878536  DT.91761807  DT.120855962  DT.120855932  DT.75100088  DT.95310595 
    DT.120855981  DT.430536  DT.102833833  DT.120855959  DT.65287722  DT.91761810  DT.100673868  DT.121641868 

    24/562 AceView cDNA sequences (see all 562):

    BQ892884 AI244410 BU170962 BM785466 BM997735 CB178439 BG281263 AI911213 
    BM455262 BI223262 AU119447 AA766721 CA391867 AI638543 AI796117 CR749214 
    CK299352 BI964188 AU138498 BQ006525 N67614 AI635171 BU069186 CB114401 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TRA2B (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                    -     -     -     -     -                             -     -     -                                                         
    SP2:                    -     -     -     -     -           -     -           -     -     -                                                         
    SP3:                                                                          -     -     -                             -                           
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for TRA2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRA2B expression in normal human tissues (normalized intensities)      TRA2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAACTGA
    TRA2B Expression
    About this image


    TRA2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TRA2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRA2B

    SOURCE GeneReport for Unigene cluster: Hs.533122

    UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995
    Tissue specificity: Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta
    and brain. Lowest expression in kidney and liver

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRA2B gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tra2b1 , 5 transformer 2 beta homolog (Drosophila)1, 5 91.67(n)1
    100(a)1
      16 (13.18 cM)5
    204621  NM_009186.41  NP_033212.11 
     222445495 
    chicken
    (Gallus gallus)
    Aves TRA2B1 transformer 2 beta homolog (Drosophila) 83.91(n)
    98.26(a)
      395403  NM_204678.1  NP_990009.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRA2B6
    transformer 2 beta homolog (Drosophila)
    95(a)
    1 ↔ 1
    3(34282799-34312952)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3984482 similar to splicing factor, arginine/serine-rich (transformer more 75.63(n)    BC044695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566122 similar to splicing factor, arginine/serine-rich 1 more 75.65(n)   394172  BC049051.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tra21 transformer 2 48.6(n)
    51.1(a)
      36619  NM_206113.1  NP_995835.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-81 Protein RSP-8 48.03(n)
    49.34(a)
      176613  NM_067132.4  NP_499533.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G357851 RNA-binding (RRM/RBD/RNP motifs) family protein 42.53(n)
    41.38(a)
      829732  NM_148402.5  NP_680768.5 
    rice
    (Oryza sativa)
    Liliopsida Os08g03859001 hypothetical protein 41.26(n)
    42.74(a)
      4345455  NM_001068241.1  NP_001061706.1 


    ENSEMBL Gene Tree for TRA2B (if available)
    TreeFam Gene Tree for TRA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRA2B gene
    RBMY1J2  RBMY1E2  RBMY1F2  RBMXL22  RBMXL32  RBMY1B2  RBMXL12  RBMY1A12  
    CIRBP2  RBM32  RBMX2  TRA2A2  RBMY1D2  
    6 SIMAP similar genes for TRA2B using alignment to 3 protein entries:     TRA2B_HUMAN (see all proteins):
    DKFZp686F18120    HSU53209    TRA2A    RBMY1A1    CIRBP    SRSF10

    TRA2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/640 SNPs in TRA2B are shown (see all 640)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615436171,2
    C--183042746(+) CACAC-/AC/CC 
            
    CAACG
    2 -- ds50010--------
    rs1445988331,2
    C--183045281(+) CCATG-/ACACAGG 2 -- ut310--------
    rs716944441,2
    C--183045283(+) CATGA-/AC/CA 
            
    CAGGT
    4 -- ut310--------
    rs1483548471,2
    C--183063745(+) CCTTT-/GAGAGGG 2 -- int10--------
    rs1414996301,2
    C--183065114(+) TTCCC-/ACAACAGC 2 -- cds10--------
    rs2007539861,2
    --183065116(+) CCCAC-/AATAGCCT 2 -- cds10--------
    rs3777191671,2
    C--183065116(+) TCCCA-/ACACAGCC 2 -- cds10--------
    rs1466938941,2
    --185500396(+) TAGTTC/TGAGAC 2 -- ds50010--------
    rs1920280321,2
    --185500425(+) CAAACC/GCTGTC 2 -- ds50010--------
    rs106566331,2
    C--185500426(+) aaccc-/TGtgtct 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRA2B (185632356 - 185655924 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRA2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660289CNV Deletion23128226
    nsv461035CNV Loss19166990


    Human Gene Mutation Database (HGMD): TRA2B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRA2B
    DNA2.0 Custom Variant and Variant Library Synthesis for TRA2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602719    OMIM disorders: --

    13 diseases for TRA2B:    About MalaCards
    tauopathy    frontotemporal dementia    spinal muscular atrophy    muscular atrophy
    dementia    cervical cancer    hypoxia    obesity
    cervicitis    alzheimer's disease    ovarian cancer    neuronitis
    breast cancer


    TRA2B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for TRA2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tauopathies 68.6 1 12649279 (1)

    Genetic Association Database (GAD): TRA2B
    Human Genome Epidemiology (HuGE) Navigator: TRA2B (3 documents)

    Export disorders for TRA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRA2B gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with TRA2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. (PubMed id 9790768)1, 2, 3, 9 Nayler O.... Stamm S. (1998)
    2. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 2, 9 Sakashita E.... Mayeda A. (2004)
    3. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. (PubMed id 9212162)1, 2, 9 Beil B.... Stamm S. (1997)
    4. Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (2004)
    8. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J....Andreadis A. (2004)
    9. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. (PubMed id 14765198)1, 2 Shin C.... Manley J.L. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6434 HGNC: 10781 AceView: SFRS10 Ensembl:ENSG00000136527 euGenes: HUgn6434
    ECgene: TRA2B Kegg: 6434 H-InvDB: TRA2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRA2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRA2B gene:
    Search GeneIP for patents involving TRA2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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