Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRA2B Gene

protein-coding GIFtS: 55
GCID: GC03M185632

Transformer 2 Beta Homolog (Drosophila)

(Previous names: splicing factor, arginine/serine-rich 10 (transformer 2...)
(Previous symbol: SFRS10)

Alzheimer's & Parkinson's Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Transformer 2 Beta Homolog (Drosophila)¹ ²		TRA2-BETA²
SFRS10¹ ² ³		TRAN2B²
Splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog, Drosophila)¹ ²		Transformer-2 Protein Homolog Beta²
Transformer-2 Protein Homolog B² ³		TRA2-beta³
TRA-2 Beta² ³		hTRA2-beta³
SRFS10² ⁵		Splicing Factor, Arginine/Serine-Rich 10³
Htra2-beta²

External Ids:	HGNC: 10781¹	Entrez Gene: 6434²	Ensembl: ENSG00000136527⁷	OMIM: 602719⁵	UniProtKB: P62995³

Export aliases for TRA2B gene to outside databases

Previous GC identifers: GC03M187110 GC03M183042

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRA2B Gene:

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which

plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for TRA2B Gene:

TRA2B (transformer 2 beta homolog (Drosophila)) is a protein-coding gene. Diseases associated with TRA2B include tauopathy, and frontotemporal dementia, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include mRNA binding and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995

Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either

activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor

neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the

effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to

pre-mRNA

Gene Wiki entry for TRA2B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NT_005612.16 NC_018914.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRA2B gene promoter:
HFH-3 p53 ATF-2 Bach2 CUTL1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 FOXI1 MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRA2B promoter sequence

Search SABiosciences Chromatin IP Primers for TRA2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRA2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2-q27 Ensembl cytogenetic band: 3q27.2 HGNC cytogenetic band: 3q26.2-q27

TRA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRA2B gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M185632: view genomic region (about GC identifiers)

Start:	185,632,356 bp from pter	End:	185,655,924 bp from pter
Size:	23,569 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995 (See protein sequence)

Recommended Name: Transformer-2 protein homolog beta

Size: 288 amino acids; 33666 Da

Subunit: Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex

with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9.

Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A

Subcellular location: Nucleus

4 PDB 3D structures from and Proteopedia for TRA2B:

2CQC (3D)

2KXN (3D)

2RRA (3D)

2RRB (3D)

Secondary accessions: B4DVK2 D3DNU3 O15449 Q15815 Q64283

Alternative splicing: 3 isoforms: P62995-1, Q15815-1 P62995-2, Q15815-2 P62995-3, Q15815-3

Explore the universe of human proteins at neXtProt for TRA2B: NX_P62995

Explore proteomics data for TRA2B at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated in the RS domains

UniProtKB: Dimethylation at Arg-241 is probably asymmetric

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_P62995

TRA2B Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230808.1 NP_004584.1

ENSEMBL proteins:

ENSP00000416959 ENSP00000259043 ENSP00000406561 ENSP00000416887 ENSP00000371626

ENSP00000343857

Human Recombinant Protein Products for TRA2B:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TRA2B OriGene Protein Over-expression Lysate for TRA2B OriGene MassSpec for TRA2B OriGene Custom Protein Services for TRA2B
	GenScript Custom Purified and Recombinant Proteins Services for TRA2B
	Novus Biologicals TRA2B Proteins Novus Biologicals TRA2B Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	9546399

TRA2B for ontologies About GeneDecksing

TRA2B Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TRA2B
	GenScript Custom Superior Antibodies Services for TRA2B
	Novus Biologicals TRA2B Antibodies
	Abcam antibodies for TRA2B
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for TRA2B
	LSBio Antibodies in human, mouse, rat for TRA2B

Assay Products for TRA2B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TRA2B
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRA2B
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

RBM: RNA binding motif (RRM) containing

2 InterPro protein domains:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P62995

ProtoNet protein and cluster: P62995

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 1 RRM (RNA recognition motif) domain

TRA2B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRA2B_HUMAN, P62995

Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either

activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor

neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the

effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to

pre-mRNA

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003729	mRNA binding	IDA	12165565
GO:0005515	protein binding	IPI	10749975

TRA2B for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tra2b):

cardiovascular system	embryogenesis	growth/size	homeostasis/metabolism	mortality/aging
normal

TRA2B for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Tra2b^tm1.2Bwir for TRA2B

inGenious Targeting Laboratory - Custom generated mouse model solutions for TRA2B

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRA2B

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRA2B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRA2B

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRA2B
		8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate TRA2B (see all 102):
		hsa-miR-579 hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-4267 hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: TRA2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TRA2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRA2B

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TRA2B
			Sirion Biotech Customized adenovirus for overexpression of TRA2B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for TRA2B (see all 8) OriGene ORF clones in mouse, rat for TRA2B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRA2B (NM_004593)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRA2B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRA2B
		Sirion Biotech Customized lentivirus for stable overexpression of TRA2B Customized lentivirus expression plasmids for stable overexpression of TRA2B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRA2B
		Search LifeMap BioReagents cell lines for TRA2B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TRA2B About

See pathways by source

SuperPath

Contained pathways About

mRNA Splicing - Major Pathway

mRNA processing

0.46

Spliceosome

0.31

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for TRA2B

mRNA processing

1 Kegg Pathway (Kegg details for TRA2B):

Spliceosome

TRA2B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TRA2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/72 Interacting proteins for TRA2B (P62995^{2, 3} ENSP00000416959⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 72)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5205773 I2D: score=1 STRING: ENSP00000221494
ENSG00000235068	Q01860³, ENSP00000405041⁴	I2D: score=1 STRING: ENSP00000405041
ENSG00000206454	Q01860³	I2D: score=1
ENSG00000229094	Q01860³	I2D: score=1
ENSG00000230336	Q01860³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000302	response to reactive oxygen species	IEA	--
GO:0000375	RNA splicing, via transesterification reactions	TAS	9546399
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA	12165565
GO:0000398	mRNA splicing, via spliceosome	IDA	9546399
GO:0048026	positive regulation of mRNA splicing, via spliceosome	IDA	15009664

TRA2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRA2B

Search CenterWatch for drugs/clinical trials and news about TRA2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRA2B gene (2 alternative transcripts):

NM_001243879.1 NM_004593.2

Unigene Cluster for TRA2B:

Transformer 2 beta homolog (Drosophila)

Hs.533122 [show with all ESTs]

Unigene Representative Sequence: AB209208

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000453386(uc010hym.3 uc003fpv.3) ENST00000492417 ENST00000463328(uc003fpt.3)

ENST00000259043 ENST00000414862 ENST00000466832 ENST00000487615(uc003fpu.3)

ENST00000456380(uc003fpx.2) ENST00000382191 ENST00000465245 ENST00000485530

ENST00000493864 ENST00000477939 ENST00000471134 ENST00000480461 ENST00000342294

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRA2B
		8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate TRA2B (see all 102):
		hsa-miR-579 hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-3653 hsa-miR-371-5p hsa-miR-4267 hsa-miR-4274

		SwitchGear 3'UTR luciferase reporter plasmid: TRA2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TRA2B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRA2B

Clone Products:		OriGene clones in human, mouse for TRA2B (see all 8) OriGene ORF clones in mouse, rat for TRA2B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TRA2B (NM_004593)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRA2B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRA2B
		Sirion Biotech Customized lentivirus for stable overexpression of TRA2B Customized lentivirus expression plasmids for stable overexpression of TRA2B

Primer Products:		OriGene qPCR primer pairs and template standards for TRA2B OriGene qSTAR qPCR primer pairs in human, mouse for TRA2B
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRA2B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRA2B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRA2B

Additional mRNA sequence:

AB209208.1 AK091863.1 AK094495.1 AK098191.1 AK125610.1 AK301118.1 AK308267.1 AK315632.1

BC000160.2 BC000451.2 BC005898.1 CR749214.1 U61267.1 U68063.1 U87836.1

24/35 DOTS entries (see all 35):

DT.91761815 DT.92360269 DT.100730598 DT.95233361 DT.100878524 DT.91761814 DT.100878535 DT.100878527

DT.97860426 DT.120855947 DT.100878536 DT.91761807 DT.120855962 DT.120855932 DT.75100088 DT.95310595

DT.120855981 DT.430536 DT.102833833 DT.120855959 DT.65287722 DT.91761810 DT.100673868 DT.121641868

24/562 AceView cDNA sequences (see all 562):

BQ892884 AI244410 BU170962 BM785466 BM997735 CB178439 BG281263 AI911213

BM455262 BI223262 AU119447 AA766721 CA391867 AI638543 AI796117 CR749214

CK299352 BI964188 AU138498 BQ006525 N67614 AI635171 BU069186 CB114401

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TRA2B (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c
SP1:							-		-		-		-		-										-		-		-
SP2:							-		-		-		-		-				-		-				-		-		-
SP3:																									-		-		-										-
SP4:
SP5:

ECgene alternative splicing isoforms for TRA2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRA2B expression in normal human tissues (normalized intensities) TRA2B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GATGAACTGA

About this image

TRA2B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/35 selected tissues (see all 35) fully expand


Epithelium
vagina ; squamous epithelial cells

Uterus
uterus, post-menopause ; glandular cells

Testis (Reproductive System) fully expand to see all 4 entries
Leydig Cells Testis Interstitium
seminal vesicle ; glandular cells

Colon (Gastrointestinal Tract) fully expand to see all 4 entries
colon ; peripheral nerve/ganglion

Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

See TRA2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRA2B

SOURCE GeneReport for Unigene cluster: Hs.533122

UniProtKB/Swiss-Prot: TRA2B_HUMAN, P62995

Tissue specificity: Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta

and brain. Lowest expression in kidney and liver

SABiosciences Custom PCR Arrays for TRA2B

Primer Products:		OriGene qPCR primer pairs and template standards for TRA2B OriGene qSTAR qPCR primer pairs in human, mouse for TRA2B
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRA2B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRA2B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRA2B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRA2B gene from 9/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tra2b^{1 , 5}	transformer 2 beta homolog (Drosophila)^{1, 5}	91.67(n)¹ 100(a)¹		16 (13.18 cM)⁵ 20462¹ NM_009186.4¹ NP_033212.1¹ 22244549⁵
chicken (Gallus gallus)	Aves	TRA2B¹	transformer 2 beta homolog (Drosophila)	83.91(n) 98.26(a)		395403 NM_204678.1 NP_990009.1
lizard (Anolis carolinensis)	Reptilia	TRA2B⁶	transformer 2 beta homolog (Drosophila)	95(a)	1 ↔ 1	3(34282799-34312952)
African clawed frog (Xenopus laevis)	Amphibia	LOC398448²	similar to splicing factor, arginine/serine-rich (transformer more	75.63(n)		BC044695.1
zebrafish (Danio rerio)	Actinopterygii	zgc56612²	similar to splicing factor, arginine/serine-rich 1 more	75.65(n)		394172 BC049051.1
fruit fly (Drosophila melanogaster)	Insecta	tra2¹	transformer 2	48.6(n) 51.1(a)		36619 NM_206113.1 NP_995835.1
worm (Caenorhabditis elegans)	Secernentea	rsp-8¹	Protein RSP-8	48.03(n) 49.34(a)		176613 NM_067132.4 NP_499533.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G35785¹	RNA-binding (RRM/RBD/RNP motifs) family protein	42.53(n) 41.38(a)		829732 NM_148402.5 NP_680768.5
rice (Oryza sativa)	Liliopsida	Os08g0385900¹	hypothetical protein	41.26(n) 42.74(a)		4345455 NM_001068241.1 NP_001061706.1

ENSEMBL Gene Tree for TRA2B (if available)
TreeFam Gene Tree for TRA2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRA2B gene

RBMY1J² RBMY1E² RBMY1F² RBMXL2² RBMXL3² RBMY1B² RBMXL1² RBMY1A1²

CIRBP² RBM3² RBMX² TRA2A² RBMY1D²

6 SIMAP similar genes for TRA2B using alignment to 3 protein entries: TRA2B_HUMAN (see all proteins):

DKFZp686F18120 HSU53209 TRA2A RBMY1A1 CIRBP SRSF10

TRA2B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61543617^1,2	C	--	183042746(+)	`CACAC-/AC/CC CAACG`	2	--	ds500¹		0	--	--	--	--
rs144598833^1,2	C	--	183045281(+)	`CCATG-/ACACAGG`	2	--	ut3¹		0	--	--	--	--
rs71694444^1,2	C	--	183045283(+)	`CATGA-/AC/CA CAGGT`	4	--	ut3¹		0	--	--	--	--
rs148354847^1,2	C	--	183063745(+)	`CCTTT-/GAGAGGG`	2	--	int¹		0	--	--	--	--
rs141499630^1,2	C	--	183065114(+)	`TTCCC-/ACAACAGC`	2	--	cds¹		0	--	--	--	--
rs200753986^1,2		--	183065116(+)	`CCCAC-/AATAGCCT`	2	--	cds¹		0	--	--	--	--
rs377719167^1,2	C	--	183065116(+)	`TCCCA-/ACACAGCC`	2	--	cds¹		0	--	--	--	--
rs146693894^1,2		--	185500396(+)	`TAGTTC/TGAGAC`	2	--	ds500¹		0	--	--	--	--
rs192028032^1,2		--	185500425(+)	`CAAACC/GCTGTC`	2	--	ds500¹		0	--	--	--	--
rs10656633^1,2	C	--	185500426(+)	`aaccc-/TGtgtct`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRA2B (185632356 - 185655924 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TRA2B: About this table

Variant ID	Type	Subtype	PubMed ID
esv2660289	CNV	Deletion	23128226
nsv461035	CNV	Loss	19166990

Human Gene Mutation Database (HGMD): TRA2B

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing TRA2B

DNA2.0 Custom Variant and Variant Library Synthesis for TRA2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 602719 OMIM disorders: --

13 diseases for TRA2B: About MalaCards

tauopathy frontotemporal dementia spinal muscular atrophy muscular atrophy

dementia cervical cancer hypoxia obesity

cervicitis alzheimer's disease ovarian cancer neuronitis

breast cancer

TRA2B for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for TRA2B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tauopathies	68.6	1	12649279 (1)

Genetic Association Database (GAD): TRA2B
Human Genome Epidemiology (HuGE) Navigator: TRA2B (3 documents)

Export disorders for TRA2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRA2B gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with TRA2B)

Utopia: connect your pdf to the dynamic
world of online information

Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. (PubMed id 9790768)^{1, 2, 3, 9} Nayler O.... Stamm S. (1998)
Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)^{1, 2, 9} Sakashita E.... Mayeda A. (2004)
Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. (PubMed id 9212162)^{1, 2, 9} Beil B.... Stamm S. (1997)
Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)^{1, 4} Elks C.E....Murray A. (2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)^{1, 2} Dettwiler S.... Barabino S.M. (2004)
Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)^{1, 2} Wang J....Andreadis A. (2004)
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. (PubMed id 14765198)^{1, 2} Shin C.... Manley J.L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6434	HGNC: 10781	AceView: SFRS10	Ensembl:ENSG00000136527	euGenes: HUgn6434
ECgene: TRA2B	Kegg: 6434	H-InvDB: TRA2B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRA2B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRA2B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRA2B gene:
Search GeneIP for patents involving TRA2B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for TRA2B
	OriGene qPCR primer pairs and template standards for TRA2B		OriGene Protein Over-expression Lysate for TRA2B
	OriGene MassSpec something-or-other for TRA2B		OriGene clones in human, mouse for TRA2B
	OriGene qSTAR qPCR primer pairs in human, mouse for TRA2B		OriGene Purified Protein for TRA2B
	OriGene ORF clones in mouse, rat for TRA2B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRA2B		OriGene Custom Protein Services for TRA2B

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRA2B
	QIAGEN SeqTarget long-range PCR primers for resequencing TRA2B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRA2B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRA2B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRA2B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRA2B

	GenScript Custom Purified and Recombinant Proteins Services for TRA2B		GenScript cDNA clones with any tag delivered in your preferred vector for TRA2B
	GenScript Custom Assay Services for TRA2B		GenScript Custom Superior Antibodies Services for TRA2B
	GenScript Custom overexpressing Cell Line Services for TRA2B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TRA2B promoter
	Search Chromatin IP Primers for TRA2B
	RT² qPCR Primer Assay in human, mouse, rat TRA2B
	Search GNC Networks for TRA2B
	SABiosciences Custom PCR Arrays for TRA2B

Search Tocris compounds for TRA2B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRA2B antibodies
	TRA2B proteins
	TRA2B lysates

	Antibodies for TRA2B
	See all of Abcam's Antibodies, Kits and Proteins for TRA2B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for TRA2B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2B

	SwitchGear 3'UTR luciferase reporter plasmids for TRA2B
	SwitchGear Promoter luciferase reporter plasmids for TRA2B

ThermoFisher Antibodies for TRA2B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRA2B

	inGenious Targeting Laboratory - Custom generated mouse model solutions for TRA2B
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRA2B

Customized:

	lentivirus for stable overexpression of TRA2B
	lentivirus expression plasmids for stable overexpression of TRA2B
	adenovirus for overexpression of TRA2B

LSBio Antibodies in human, mouse, rat for TRA2B

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRA2B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

TRA2B Gene

Transformer 2 Beta Homolog (Drosophila)

Aliases
for TRA2B gene

Summaries
for TRA2B gene

Genomic Views
for TRA2B gene

Proteins
for TRA2B gene

Protein Domains /
Families
for TRA2B gene

Function
for TRA2B gene

Pathways & Interactions
for TRA2B gene

Drugs & Compounds
for TRA2B gene

Transcripts
for TRA2B gene

Expression
for TRA2B gene

Orthologs
for TRA2B gene

Paralogs
for TRA2B gene

Genomic Variants
for TRA2B gene

Disorders / Diseases
for TRA2B gene

Publications
for TRA2B gene

External Searches for TRA2B gene

Genome Databases showing TRA2B gene

Other Databases showing TRA2B gene

Specialized Databases showing TRA2B gene

Intellectual Property
for TRA2B gene

Products
for TRA2B gene

View Random Gene

Advanced Search

Export list of displayed genes

TRA2B Gene

Transformer 2 Beta Homolog (Drosophila)

Aliasesfor TRA2B gene

Summariesfor TRA2B gene

Genomic Viewsfor TRA2B gene

Proteinsfor TRA2B gene

Protein Domains /Familiesfor TRA2B gene

Functionfor TRA2B gene

Pathways & Interactionsfor TRA2B gene

Drugs & Compoundsfor TRA2B gene

Transcriptsfor TRA2B gene

Expression for TRA2B gene

Orthologsfor TRA2B gene

Paralogsfor TRA2B gene

Genomic Variantsfor TRA2B gene

Disorders / Diseasesfor TRA2B gene

Publicationsfor TRA2B gene

External Searches for TRA2B gene

Genome Databases showing TRA2B gene

Other Databases showing TRA2B gene

Specialized Databases showing TRA2B gene

Intellectual Propertyfor TRA2B gene

Productsfor TRA2B gene

View Random Gene

Aliases
for TRA2B gene

Summaries
for TRA2B gene

Genomic Views
for TRA2B gene

Proteins
for TRA2B gene

Protein Domains /
Families
for TRA2B gene

Function
for TRA2B gene

Pathways & Interactions
for TRA2B gene

Drugs & Compounds
for TRA2B gene

Transcripts
for TRA2B gene

Expression
for TRA2B gene

Orthologs
for TRA2B gene

Paralogs
for TRA2B gene

Genomic Variants
for TRA2B gene

Disorders / Diseases
for TRA2B gene

Publications
for TRA2B gene

Intellectual Property
for TRA2B gene

Products
for TRA2B gene