Aliases for TRA2B Gene
External Ids for TRA2B Gene
Previous HGNC Symbols for TRA2B Gene
Previous GeneCards Identifiers for TRA2B Gene
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRA2B Gene
TRA2B (Transformer 2 Beta Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with TRA2B include tauopathy. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is CIRBP.
UniProtKB/Swiss-Prot for TRA2B Gene
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.