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Aliases for TRA2A Gene

Aliases for TRA2A Gene

  • Transformer 2 Alpha Homolog 2 3 5
  • Transformer-2 Protein Homolog A 3 4
  • TRA-2 Alpha 3 4
  • TRA2-Alpha 3 4
  • Transformer 2 Alpha Homolog (Drosophila) 2
  • Putative MAPK Activating Protein PM24 3
  • Transformer-2 Protein Homolog Alpha 3
  • Transformer-2 Alpha 3
  • Htra-2 Alpha 3
  • Tra2alpha 3
  • HSU53209 3
  • AWMS1 3

External Ids for TRA2A Gene

Previous GeneCards Identifiers for TRA2A Gene

  • GC07M023252
  • GC07M023286
  • GC07M023317
  • GC07M023510
  • GC07M023544
  • GC07M023429

Summaries for TRA2A Gene

Entrez Gene Summary for TRA2A Gene

  • This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for TRA2A Gene

TRA2A (Transformer 2 Alpha Homolog) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRA2B.

UniProtKB/Swiss-Prot for TRA2A Gene

  • Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

Gene Wiki entry for TRA2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRA2A Gene

Genomics for TRA2A Gene

Regulatory Elements for TRA2A Gene

Enhancers for TRA2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G023181 1.2 ENCODE 19.9 +349.4 349392 3.3 MLX CREB3L1 FEZF1 DMAP1 YY1 SP3 NFYC TBX21 MEF2D SSRP1 KLHL7-AS1 TRA2A ENSG00000226816 SNHG26 ENSG00000226329 EEF1A1P6 NUPL2
GH07G022575 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +954.1 954107 3.9 TBP PKNOX1 CBX3 RAD21 CHAMP1 RFX5 YY1 GATA2 CBX5 SMARCC2 IL6 LOC541472 STEAP1B TRA2A LOC100506178 ENSG00000232949
GH07G023462 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 +62.7 62672 13.3 MLX CREB3L1 AGO1 FEZF1 DMAP1 ZNF263 SP3 NFYC TBX21 MEF2D EEF1A1P6 TRA2A IGF2BP3 CCDC126 KLHL7-AS1 NUPL2 MALSU1 GC07P023450
GH07G023272 1.3 Ensembl ENCODE 11.8 +258.5 258547 1.6 PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF2 ZNF143 ZNF207 FOS DEK KLHL7-AS1 TRA2A GPNMB MALSU1
GH07G024052 1.1 FANTOM5 ENCODE 11.8 -521.0 -520972 1.2 TBP INSM2 BRCA1 RFX5 ZNF366 SMARCC2 RCOR1 FOS SMARCC1 NFYA TRA2A ENSG00000227930 NPY LOC105375188 RNA5SP228
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRA2A on UCSC Golden Path with GeneCards custom track

Promoters for TRA2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209515 841 2401 HDGF FOXA2 PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for TRA2A Gene

Chromosome:
7
Start:
23,504,780 bp from pter
End:
23,532,041 bp from pter
Size:
27,262 bases
Orientation:
Minus strand

Genomic View for TRA2A Gene

Genes around TRA2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRA2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRA2A Gene

Proteins for TRA2A Gene

  • Protein details for TRA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13595-TRA2A_HUMAN
    Recommended name:
    Transformer-2 protein homolog alpha
    Protein Accession:
    Q13595
    Secondary Accessions:
    • B4DQI6
    • B4DUA9
    • E9PD75

    Protein attributes for TRA2A Gene

    Size:
    282 amino acids
    Molecular mass:
    32689 Da
    Quaternary structure:
    • Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30.

    Alternative splice isoforms for TRA2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRA2A Gene

Post-translational modifications for TRA2A Gene

No data available for DME Specific Peptides for TRA2A Gene

Domains & Families for TRA2A Gene

Gene Families for TRA2A Gene

Protein Domains for TRA2A Gene

Graphical View of Domain Structure for InterPro Entry

Q13595

UniProtKB/Swiss-Prot:

TRA2A_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with TRA2A: view

Function for TRA2A Gene

Molecular function for TRA2A Gene

UniProtKB/Swiss-Prot Function:
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
genes like me logo Genes that share ontologies with TRA2A: view
genes like me logo Genes that share phenotypes with TRA2A: view

Animal Model Products

CRISPR Products

miRNA for TRA2A Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRA2A Gene

Localization for TRA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRA2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRA2A gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9546399
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TRA2A: view

Pathways & Interactions for TRA2A Gene

SuperPathways for TRA2A Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with TRA2A: view

Pathways by source for TRA2A Gene

1 KEGG pathway for TRA2A Gene

Gene Ontology (GO) - Biological Process for TRA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IDA 9546399
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with TRA2A: view

No data available for SIGNOR curated interactions for TRA2A Gene

Drugs & Compounds for TRA2A Gene

No Compound Related Data Available

Transcripts for TRA2A Gene

Unigene Clusters for TRA2A Gene

Transformer 2 alpha homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRA2A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1: - - - - - - -
SP2: -
SP3: - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: -
SP11:

Relevant External Links for TRA2A Gene

GeneLoc Exon Structure for
TRA2A
ECgene alternative splicing isoforms for
TRA2A

Expression for TRA2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRA2A Gene

This gene is overexpressed in Nasal epithelium (19.3) and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRA2A Gene



Protein tissue co-expression partners for TRA2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRA2A Gene:

TRA2A

SOURCE GeneReport for Unigene cluster for TRA2A Gene:

Hs.445652

Evidence on tissue expression from TISSUES for TRA2A Gene

  • Nervous system(2.7)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with TRA2A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRA2A Gene

Orthologs for TRA2A Gene

This gene was present in the common ancestor of animals.

Orthologs for TRA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRA2A 34 35
  • 99.41 (n)
oppossum
(Monodelphis domestica)
Mammalia TRA2A 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRA2A 34 35
  • 95.63 (n)
cow
(Bos Taurus)
Mammalia TRA2A 34 35
  • 95.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRA2A 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tra2a 34
  • 89.24 (n)
mouse
(Mus musculus)
Mammalia Tra2a 34 16 35
  • 88.45 (n)
chicken
(Gallus gallus)
Aves TRA2A 34 35
  • 82.66 (n)
lizard
(Anolis carolinensis)
Reptilia TRA2A 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tra2a 34
  • 75.67 (n)
Str.6565 34
zebrafish
(Danio rerio)
Actinopterygii tra2a 34 35
  • 70.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3457 34
fruit fly
(Drosophila melanogaster)
Insecta tra2 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-8 35
  • 36 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4304 34
Species where no ortholog for TRA2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRA2A Gene

ENSEMBL:
Gene Tree for TRA2A (if available)
TreeFam:
Gene Tree for TRA2A (if available)

Paralogs for TRA2A Gene

(5) SIMAP similar genes for TRA2A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TRA2A Gene

genes like me logo Genes that share paralogs with TRA2A: view

Variants for TRA2A Gene

Sequence variations from dbSNP and Humsavar for TRA2A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000039298 -- 23,519,949(+) CCAGC(C/T)GGGCG intron-variant
rs1000208761 -- 23,531,812(+) TTCCT(C/T)CACAT reference, missense, utr-variant-5-prime
rs1000308887 -- 23,504,300(+) CCCCG(-/TC)TCTAC downstream-variant-500B
rs1000326273 -- 23,526,332(+) ATAGG(A/G)CCAAA intron-variant
rs1000495848 -- 23,520,096(+) CTGTG(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRA2A Gene

Variant ID Type Subtype PubMed ID
esv3891087 CNV loss 25118596
nsv509193 CNV insertion 20534489
nsv5662 CNV insertion 18451855
nsv7393 OTHER inversion 18451855

Variation tolerance for TRA2A Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRA2A Gene

Human Gene Mutation Database (HGMD)
TRA2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRA2A Gene

Disorders for TRA2A Gene

Relevant External Links for TRA2A

Genetic Association Database (GAD)
TRA2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRA2A

No disorders were found for TRA2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRA2A Gene

Publications for TRA2A Gene

  1. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. (PMID: 8799144) Dauwalder B. … Mattox W. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. (PMID: 9546399) Tacke R. … Manley J.L. (Cell 1998) 2 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for TRA2A Gene

Sources for TRA2A Gene

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