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TRA2A Gene

protein-coding   GIFtS: 57
GCID: GC07M023544

Transformer 2 Alpha Homolog (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transformer 2 Alpha Homolog (Drosophila)1 2     Tra2alpha2
Transformer-2 Protein Homolog A2 3     Htra-2 Alpha2
TRA2-alpha2 3     htra-2-alpha2
TRA-2 Alpha2 3     Putative MAPK Activating Protein PM242
AWMS12     Transformer-2 Alpha2
HSU532092     Transformer-2 Protein Homolog Alpha2

External Ids:    HGNC: 166451   Entrez Gene: 298962   Ensembl: ENSG000001645487   OMIM: 6027185   UniProtKB: Q135953   

Export aliases for TRA2A gene to outside databases

Previous GC identifers: GC07M023252 GC07M023286 GC07M023317 GC07M023510 GC07M023429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRA2A Gene:
This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition
motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the
regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene.
(provided by RefSeq, Sep 2013)

GeneCards Summary for TRA2A Gene:
TRA2A (transformer 2 alpha homolog (Drosophila)) is a protein-coding gene. Diseases associated with TRA2A include hiv-1, and malaria. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RBMY1J.

UniProtKB/Swiss-Prot: TRA2A_HUMAN, Q13595
Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing

Gene Wiki entry for TRA2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRA2A gene promoter:
         C/EBPbeta   Pbx1a   POU2F1   POU2F1a   POU2F1b   POU2F1c   HNF-3beta   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRA2A promoter sequence
   Search Chromatin IP Primers for TRA2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3   Ensembl cytogenetic band:  7p15.3   HGNC cytogenetic band: 7p15.3

TRA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRA2A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M023544:  view genomic region     (about GC identifiers)

Start:
23,544,399 bp from pter      End:
23,571,660 bp from pter
Size:
27,262 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 23,596,242-23,623,480     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRA2A_HUMAN, Q13595 (See protein sequence)
Recommended Name: Transformer-2 protein homolog alpha  
Size: 282 amino acids; 32689 Da
Subunit: Binds to A3 enhancer proteins SRp75, SRp55, SRp40 and SRp30
Alternative splicing: 2 isoforms:  Q13595-1   Q13595-2   

Explore the universe of human proteins at neXtProt for TRA2A: NX_Q13595

Explore proteomics data for TRA2A at MOPED

Post-translational modifications: 

  • Phosphorylated in the RS domains1
  • Ubiquitination2 at Lys198
  • Modification sites at PhosphoSitePlus

  • See TRA2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269686.1  NP_001269687.1  NP_001269688.1  NP_037425.1  

    ENSEMBL proteins: 
     ENSP00000297071   ENSP00000413898   ENSP00000376290   ENSP00000441116  

    TRA2A Human Recombinant Protein Products:

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    Novus Biologicals TRA2A Proteins
    Novus Biologicals TRA2A Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TRA2A Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q13595

    ProtoNet protein and cluster: Q13595

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TRA2A_HUMAN, Q13595
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TRA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRA2A_HUMAN, Q13595
    Function: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    TRA2A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRA2A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRA2A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRA2A

    miRNA
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    miRTarBase miRNAs that target TRA2A:
    hsa-mir-374b-5p (MIRT016048), hsa-mir-196b-5p (MIRT042676), hsa-mir-30c-5p (MIRT047833)

    Block miRNA regulation of human, mouse, rat TRA2A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRA2A
    SwitchGear 3'UTR luciferase reporter plasmidTRA2A 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat TRA2A

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    GenScript: all cDNA clones in your preferred vector: TRA2A (NM_013293)
    Sino Biological Human cDNA Clone for TRA2A
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRA2A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRA2A_HUMAN, Q13595: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9546399
    GO:0005730nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    TRA2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRA2A About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for TRA2A):
        Spliceosome


    TRA2A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRA2A
    Interactions:

        Search GeneGlobe Interaction Network for TRA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRA2A (Q135952, 3 ENSP000002970714) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SELENBP1Q132282, 3, ENSP000003578614MINT-8270066 I2D: score=2 STRING: ENSP00000357861
    C11orf58O001932, 3MINT-8249931 I2D: score=2 
    CDK2AP2O759562, 3MINT-8251293 I2D: score=2 
    NUDT21O438092, 3MINT-8264593 I2D: score=2 
    TNNT1P138052, 3MINT-8275094 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IDA9546399

    TRA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRA2A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRA2A gene (4 alternative transcripts): 
    NM_001282757.1  NM_001282758.1  NM_001282759.1  NM_013293.4  

    Unigene Cluster for TRA2A:

    Transformer 2 alpha homolog (Drosophila)
    Hs.445652  [show with all ESTs]
    Unigene Representative Sequence: NM_013293
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297071(uc003swi.3 uc011jzb.2 uc011jzc.2 uc011jzd.2)
    ENST00000497730 ENST00000475970 ENST00000482395 ENST00000486934 ENST00000494255
    ENST00000474586 ENST00000490942 ENST00000448549 ENST00000392502(uc010kuo.1)
    ENST00000538367
    miRNA
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    Block miRNA regulation of human, mouse, rat TRA2A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TRA2A
    SwitchGear 3'UTR luciferase reporter plasmidTRA2A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRA2A
    Predesigned siRNA for gene silencing in human, mouse, rat TRA2A
    Clone
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    OriGene clones in human, mouse for TRA2A (see all 8)
    OriGene ORF clones in mouse, rat for TRA2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRA2A (NM_013293)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRA2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRA2A
    Primer
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    OriGene qPCR primer pairs and template standards for TRA2A
    OriGene qSTAR qPCR primer pairs in human, mouse for TRA2A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRA2A
      QuantiTect SYBR Green Assays in human, mouse, rat TRA2A
      QuantiFast Probe-based Assays in human, mouse, rat TRA2A

    Additional mRNA sequence: 

    AB097048.1 AK298815.1 AK300565.1 AK300741.1 AK310719.1 AK311687.1 AK314801.1 BC017094.2 
    U53209.1 

    19 DOTS entries:

    DT.451629  DT.100693550  DT.121066209  DT.116073  DT.437991  DT.100800623  DT.100800628  DT.100800621 
    DT.100679532  DT.100800626  DT.100800624  DT.40132946  DT.448864  DT.100672906  DT.100696265  DT.116074 
    DT.80100403  DT.91798077  DT.95146134 

    Selected AceView cDNA sequences (see all 215):

    AU138294 AA765689 CA435708 BU675822 BX645836 CB139201 CA941127 AI740726 
    AI267910 AU117142 BG250879 BI838386 BQ880693 CA866155 BF194798 AA455812 
    AW070693 AA911407 BQ019833 AV660622 AA383448 CR616661 BQ286778 BM314900 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRA2A (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
    SP1:                    -     -     -     -     -     -     -                                                                                       
    SP2:                                                        -                                                                                       
    SP3:                    -     -     -           -     -     -                                                                                       
    SP4:                    -     -     -     -     -     -     -                 -     -     -                                                         
    SP5:                    -                 -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for TRA2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRA2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGAAAAG
    TRA2A Expression
    About this image


    TRA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)
    TRA2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRA2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445652
        Custom PCR Arrays for TRA2A
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat TRA2A
    QuantiFast Probe-based Assays in human, mouse, rat TRA2A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRA2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRA2A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tra2a1 , 5 transformer 2 alpha homolog (Drosophila)1, 5 88.45(n)1
    98.8(a)1
      6 (23.84 cM)5
    1012141  NM_198102.21  NP_932770.21 
     492439215 
    chicken
    (Gallus gallus)
    Aves TRA2A1 transformer 2 alpha homolog (Drosophila) 82.66(n)
    95.93(a)
      420618  NM_001006360.1  NP_001006360.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRA2A6
    transformer 2 alpha homolog (Drosophila)
    97(a)
    1 ↔ 1
    6(30627836-30643424)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044990.12   -- 77.28(n)    BC044990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tra2a1 transformer-2 alpha 70.03(n)
    83.87(a)
      393388  NM_200416.1  NP_956710.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tra26
    transformer 2
    44(a)
    1 → many
    2R(10489509-10491857)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-86
    Protein RSP-8, isoform a
    36(a)
    1 → many
    III(11826215-11831475) WBGene00004705


    ENSEMBL Gene Tree for TRA2A (if available)
    TreeFam Gene Tree for TRA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRA2A gene
    RBMY1J2  RBMY1E2  RBMY1F2  TRA2B2  RBMXL22  RBMXL32  RBMY1B2  RBMXL12  
    RBMY1A12  CIRBP2  RBM32  RBMX2  RBMY1D2  
    5 SIMAP similar genes for TRA2A using alignment to 4 protein entries:     TRA2A_HUMAN (see all proteins):
    HSU53209    DKFZp686F18120    TRA2B    CIRBP    FUSIP1

    TRA2A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TRA2A
    PGOHUM00000244027 PGOHUM00000244028


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRA2A (see all 659)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925534131,2
    --23543964(+) GGGCGC/TCTGTA 1 -- ds50010--------
    rs1878119441,2
    C--23543987(+) CGGGAA/GGCTGA 1 -- ds50010--------
    rs285979211,2
    C,F--23544015(+) AACCCG/CGGAGG 1 -- ds50012Minor allele frequency- C:0.25NA 4
    rs1931890881,2
    C--23544077(+) AGAGCA/GAGACT 1 -- ds50010--------
    rs1836181031,2
    --23544138(+) TGCTGA/GTACTG 1 -- ds50010--------
    rs1895533981,2
    --23544140(+) CTGGTA/GCTGAA 1 -- ds50010--------
    rs1159626731,2
    C,F--23544166(+) CAATTC/TGGTCT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1811619741,2
    --23544167(+) AATTCA/GGTCTC 1 -- ds50010--------
    rs1511770011,2
    C--23544227(+) AAGGA-/ATAACAT 1 -- ds50010--------
    rs755458371,2
    F--23544236(+) CATTCT/CAGTGT 1 -- ds50011Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for TRA2A (23544399 - 23571660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRA2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5662CNV Insertion18451855
    nsv509193CNV Insertion20534489
    nsv887843CNV Gain21882294
    nsv887842CNV Gain21882294
    nsv7393OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): TRA2A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRA2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602718    OMIM disorders: --

    3 diseases for TRA2A:    
    About MalaCards
    hiv-1    malaria    neuroblastoma


    TRA2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRA2A

    Export disorders for TRA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRA2A gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with TRA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. (PubMed id 8799144)1, 2, 3, 9 Dauwalder B.... Mattox W. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. (PubMed id 9546399)1, 2, 3 Tacke R.... Manley J.L. (Cell 1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA. (PubMed id 23255807)1 Erkelenz S....Schaal H. (J. Virol. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    10. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29896 HGNC: 16645 AceView: TRA2A Ensembl:ENSG00000164548 euGenes: HUgn29896
    ECgene: TRA2A Kegg: 29896 H-InvDB: TRA2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRA2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRA2A gene:
    Search GeneIP for patents involving TRA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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