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Aliases for TPX2 Gene

Aliases for TPX2 Gene

  • TPX2, Microtubule Nucleation Factor 2
  • TPX2, Microtubule-Associated 2 3 5
  • Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2 3 4
  • Restricted Expression Proliferation-Associated Protein 100 3 4
  • Hepatocellular Carcinoma-Associated Antigen 519 3 4
  • Hepatocellular Carcinoma-Associated Antigen 90 3 4
  • Protein Fls353 3 4
  • C20orf1 3 4
  • C20orf2 3 4
  • HCA519 3 4
  • DIL-2 3 4
  • P100 3 4
  • DIL2 3 4
  • Restricted Expression Proliferation Associated Protein 100 3
  • TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) 2
  • Preferentially Expressed In Colorectal Cancer 3
  • TPX2, Microtubule-Associated Protein Homolog 3
  • Differentially Expressed In Lung Cells 3
  • TPX2, Microtubule-Associated, Homolog 3
  • Chromosome 20 Open Reading Frame 1 2
  • GD:C20orf1 3
  • FLS353 3
  • REPP86 3
  • HCTP4 3

External Ids for TPX2 Gene

Previous HGNC Symbols for TPX2 Gene

  • C20orf2
  • C20orf1

Previous GeneCards Identifiers for TPX2 Gene

  • GC20P031024
  • GC20P031072
  • GC20P031071
  • GC20P029790
  • GC20P030326
  • GC20P027115

Summaries for TPX2 Gene

GeneCards Summary for TPX2 Gene

TPX2 (TPX2, Microtubule Nucleation Factor) is a Protein Coding gene. Diseases associated with TPX2 include hepatocellular carcinoma. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and protein kinase binding.

UniProtKB/Swiss-Prot for TPX2 Gene

  • Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Gene Wiki entry for TPX2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPX2 Gene

Genomics for TPX2 Gene

Regulatory Elements for TPX2 Gene

Genomic Location for TPX2 Gene

Chromosome:
20
Start:
31,733,819 bp from pter
End:
31,801,805 bp from pter
Size:
67,987 bases
Orientation:
Plus strand

Genomic View for TPX2 Gene

Genes around TPX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPX2 Gene

Proteins for TPX2 Gene

  • Protein details for TPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW0-TPX2_HUMAN
    Recommended name:
    Targeting protein for Xklp2
    Protein Accession:
    Q9ULW0
    Secondary Accessions:
    • Q96RR5
    • Q9H1R4
    • Q9NRA3
    • Q9UFN9
    • Q9UL00
    • Q9Y2M1

    Protein attributes for TPX2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85653 Da
    Quaternary structure:
    • Interacts with AURKA (PubMed:14580337, PubMed:18662907, PubMed:18663142). Interacts with importin-alpha; leading to inactivate TPX2 (PubMed:26165940).

    Three dimensional structures from OCA and Proteopedia for TPX2 Gene

    Alternative splice isoforms for TPX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPX2 Gene

Proteomics data for TPX2 Gene at MOPED

Post-translational modifications for TPX2 Gene

  • Ubiquitination at Lys 44, Lys 48, Lys 524, and Lys 567
  • Modification sites at PhosphoSitePlus

Other Protein References for TPX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TPX2 (TPX2)

No data available for DME Specific Peptides for TPX2 Gene

Domains & Families for TPX2 Gene

Protein Domains for TPX2 Gene

Suggested Antigen Peptide Sequences for TPX2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULW0

UniProtKB/Swiss-Prot:

TPX2_HUMAN :
  • Belongs to the TPX2 family.
Family:
  • Belongs to the TPX2 family.
genes like me logo Genes that share domains with TPX2: view

No data available for Gene Families for TPX2 Gene

Function for TPX2 Gene

Molecular function for TPX2 Gene

UniProtKB/Swiss-Prot Function:
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).

Gene Ontology (GO) - Molecular Function for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 14580337
genes like me logo Genes that share ontologies with TPX2: view
genes like me logo Genes that share phenotypes with TPX2: view

Animal Model Products

miRNA for TPX2 Gene

miRTarBase miRNAs that target TPX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPX2 Gene

Localization for TPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPX2 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269 PubMed:19208764}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPX2 Gene COMPARTMENTS Subcellular localization image for TPX2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle ISS 18663142
GO:0043203 axon hillock IEA --
genes like me logo Genes that share ontologies with TPX2: view

Pathways & Interactions for TPX2 Gene

genes like me logo Genes that share pathways with TPX2: view

Pathways by source for TPX2 Gene

Gene Ontology (GO) - Biological Process for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division TAS 9207457
GO:0032147 activation of protein kinase activity IDA 14580337
GO:0051301 cell division IEA --
GO:0060236 regulation of mitotic spindle organization ISS 18663142
GO:0090307 mitotic spindle assembly IDA 26165940
genes like me logo Genes that share ontologies with TPX2: view

No data available for SIGNOR curated interactions for TPX2 Gene

Drugs & Compounds for TPX2 Gene

(2) Drugs for TPX2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TPX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPX2: view

Transcripts for TPX2 Gene

Unigene Clusters for TPX2 Gene

TPX2, microtubule-associated, homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10: - - - - - -
SP11:
SP12: -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TPX2 Gene

GeneLoc Exon Structure for
TPX2
ECgene alternative splicing isoforms for
TPX2

Expression for TPX2 Gene

mRNA expression in normal human tissues for TPX2 Gene

mRNA differential expression in normal tissues according to GTEx for TPX2 Gene

This gene is overexpressed in Testis (x5.8).

Protein differential expression in normal tissues from HIPED for TPX2 Gene

This gene is overexpressed in Lung (27.8), Urinary Bladder (11.3), Liver (11.3), and Rectum (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPX2 Gene



SOURCE GeneReport for Unigene cluster for TPX2 Gene Hs.244580

mRNA Expression by UniProt/SwissProt for TPX2 Gene

Q9ULW0-TPX2_HUMAN
Tissue specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues.
genes like me logo Genes that share expression patterns with TPX2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for TPX2 Gene

Orthologs for TPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPX2 35
  • 99.46 (n)
  • 99.06 (a)
TPX2 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPX2 36
  • 87 (a)
OneToOne
TPX2 35
  • 87.55 (n)
  • 87.07 (a)
dog
(Canis familiaris)
Mammalia TPX2 35
  • 91.28 (n)
  • 90.6 (a)
TPX2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpx2 36
  • 79 (a)
OneToOne
Tpx2 16
Tpx2 35
  • 82.19 (n)
  • 79.62 (a)
oppossum
(Monodelphis domestica)
Mammalia TPX2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPX2 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpx2 35
  • 82.37 (n)
  • 79.62 (a)
chicken
(Gallus gallus)
Aves TPX2 36
  • 56 (a)
OneToOne
TPX2 35
  • 65.47 (n)
  • 59.61 (a)
lizard
(Anolis carolinensis)
Reptilia TPX2 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia TPX2 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8066 35
tpx2 35
  • 57.19 (n)
  • 52.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2378 35
zebrafish
(Danio rerio)
Actinopterygii tpx2 36
  • 46 (a)
OneToOne
wufa12d08 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10570 36
  • 34 (a)
OneToOne
Species with no ortholog for TPX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPX2 Gene

ENSEMBL:
Gene Tree for TPX2 (if available)
TreeFam:
Gene Tree for TPX2 (if available)

Paralogs for TPX2 Gene

(2) SIMAP similar genes for TPX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPX2: view

No data available for Paralogs for TPX2 Gene

Variants for TPX2 Gene

Sequence variations from dbSNP and Humsavar for TPX2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036269 A colorectal cancer sample
rs723906 -- 31,786,916(-) AAATC(C/G)TATCA intron-variant
rs2274581 -- 31,771,721(+) GAATG(C/G)TATAA intron-variant
rs4438562 -- 31,792,571(+) ctttg(C/T)gaggc intron-variant
rs6060909 -- 31,732,161(+) atcac(C/T)tgagg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPX2 Gene

Variant ID Type Subtype PubMed ID
nsv3346 CNV Insertion 18451855

Variation tolerance for TPX2 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.14; 38.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPX2 Gene

HapMap Linkage Disequilibrium report
TPX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPX2 Gene

Disorders for TPX2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPX2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search TPX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPX2

Genetic Association Database (GAD)
TPX2
Human Genome Epidemiology (HuGE) Navigator
TPX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPX2
genes like me logo Genes that share disorders with TPX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPX2 Gene

Publications for TPX2 Gene

  1. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PMID: 9207457) Heidebrecht H.J. … Parwaresch R. (Blood 1997) 2 3 4 23 67
  2. Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PMID: 10393424) Zhang Y. … Parwaresch R. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Expression of TPX2 in salivary gland carcinomas. (PMID: 19148505) Shigeishi H. … Kamata N. (Oncol. Rep. 2009) 3 23
  4. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. (PMID: 19208764) Moss D.K. … Lane J.D. (J. Cell Sci. 2009) 3 23
  5. Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas. (PMID: 19424574) Shigeishi H. … Kamata N. (Int. J. Oncol. 2009) 3 23

Products for TPX2 Gene

Sources for TPX2 Gene

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