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Aliases for TPX2 Gene

Aliases for TPX2 Gene

  • TPX2, Microtubule-Associated 2 3
  • C20orf1 3 4 6
  • P100 3 4 6
  • Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2 3 4
  • Restricted Expression Proliferation-Associated Protein 100 3 4
  • Hepatocellular Carcinoma-Associated Antigen 519 3 4
  • Hepatocellular Carcinoma-Associated Antigen 90 3 4
  • Protein Fls353 3 4
  • C20orf2 3 4
  • HCA519 3 4
  • DIL-2 3 4
  • DIL2 3 4
  • Restricted Expression Proliferation Associated Protein 100 3
  • TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) 2
  • Preferentially Expressed In Colorectal Cancer 3
  • TPX2, Microtubule-Associated Protein Homolog 3
  • Differentially Expressed In Lung Cells 3
  • TPX2, Microtubule-Associated, Homolog 3
  • Chromosome 20 Open Reading Frame 1 2
  • Targeting Protein For Xklp2 3
  • GD:C20orf1 3
  • FLS353 3
  • REPP86 3
  • HCTP4 3

External Ids for TPX2 Gene

Previous Symbols for TPX2 Gene

  • C20orf2
  • C20orf1

Summaries for TPX2 Gene

GeneCards Summary for TPX2 Gene

TPX2 (TPX2, Microtubule-Associated) is a Protein Coding gene. Diseases associated with TPX2 include colorectal cancer and hepatocellular carcinoma. Among its related pathways are Cell Cycle / Checkpoint Control and Aurora A signaling. GO annotations related to this gene include GTP binding and protein kinase binding.

UniProtKB/Swiss-Prot for TPX2 Gene

  • Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation.

Gene Wiki entry for TPX2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPX2 Gene

Genomics for TPX2 Gene

Genomic Location for TPX2 Gene

Start:
31,739,101 bp from pter
End:
31,801,805 bp from pter
Size:
62,705 bases
Orientation:
Plus strand

Genomic View for TPX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPX2 Gene

Regulatory Elements for TPX2 Gene

Proteins for TPX2 Gene

  • Protein details for TPX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW0-TPX2_HUMAN
    Recommended name:
    Targeting protein for Xklp2
    Protein Accession:
    Q9ULW0
    Secondary Accessions:
    • Q96RR5
    • Q9H1R4
    • Q9NRA3
    • Q9UFN9
    • Q9UL00
    • Q9Y2M1

    Protein attributes for TPX2 Gene

    Size:
    747 amino acids
    Molecular mass:
    85653 Da
    Quaternary structure:
    • Interacts with AURKA.

    Three dimensional structures from OCA and Proteopedia for TPX2 Gene

    Alternative splice isoforms for TPX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPX2 Gene

Proteomics data for TPX2 Gene at MOPED

Post-translational modifications for TPX2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys48, Lys75, Lys524, and Lys567

Other Protein References for TPX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TPX2 Gene

Domains for TPX2 Gene

Protein Domains for TPX2 Gene

UniProtKB/Swiss-Prot:

TPX2_HUMAN
Family:
  • Belongs to the TPX2 family.:
    • Q9ULW0
genes like me logo Genes that share domains with TPX2: view

No data available for Gene Families for TPX2 Gene

Function for TPX2 Gene

Molecular function for TPX2 Gene

UniProtKB/Swiss-Prot Function: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at Thr-288 and protects this residue against dephosphorylation.

Gene Ontology (GO) - Molecular Function for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14580337
GO:0005524 ATP binding TAS 10512675
GO:0005525 GTP binding TAS 10512675
GO:0019901 protein kinase binding IPI 14580337
genes like me logo Genes that share ontologies with TPX2: view
genes like me logo Genes that share phenotypes with TPX2: view

miRNA for TPX2 Gene

miRTarBase miRNAs that target TPX2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPX2 Gene

Localization for TPX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPX2 Gene

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPX2 Gene COMPARTMENTS Subcellular localization image for TPX2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 colocalizes_with spindle pole IDA 14718566
GO:0005634 nucleus TAS 9207457
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle ISS 18663142
genes like me logo Genes that share ontologies with TPX2: view

Pathways for TPX2 Gene

genes like me logo Genes that share pathways with TPX2: view

Pathways by source for TPX2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TPX2 Gene
2 Cell Signaling Technology pathways for TPX2 Gene

Gene Ontology (GO) - Biological Process for TPX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0008283 cell proliferation TAS 10512675
GO:0032147 activation of protein kinase activity IDA 14580337
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with TPX2: view

Compounds for TPX2 Gene

(3) Novoseek inferred chemical compound relationships for TPX2 Gene

Compound -log(P) Hits PubMed IDs
gtp 21.3 4
serine 8.97 1
atp 0 2
genes like me logo Genes that share compounds with TPX2: view

Transcripts for TPX2 Gene

Unigene Clusters for TPX2 Gene

TPX2, microtubule-associated, homolog (Xenopus laevis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPX2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10: - - - - - -
SP11:
SP12: -

ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
SP1: -
SP2: - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TPX2 Gene

GeneLoc Exon Structure for
TPX2
ECgene alternative splicing isoforms for
TPX2

Expression for TPX2 Gene

mRNA expression in normal human tissues for TPX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPX2 Gene

This gene is overexpressed in Testis (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPX2 Gene

SOURCE GeneReport for Unigene cluster for TPX2 Gene Hs.244580

mRNA Expression by UniProt/SwissProt for TPX2 Gene

Q9ULW0-TPX2_HUMAN
Tissue specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues
genes like me logo Genes that share expressions with TPX2: view

Orthologs for TPX2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPX2 36
  • 99.46 (n)
  • 99.06 (a)
TPX2 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPX2 36
  • 87.55 (n)
  • 87.07 (a)
TPX2 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPX2 36
  • 91.28 (n)
  • 90.6 (a)
TPX2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpx2 36
  • 82.19 (n)
  • 79.62 (a)
Tpx2 16
Tpx2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPX2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPX2 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpx2 36
  • 82.37 (n)
  • 79.62 (a)
chicken
(Gallus gallus)
Aves TPX2 36
  • 65.47 (n)
  • 59.61 (a)
TPX2 37
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPX2 37
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia TPX2 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8066 36
tpx2 36
  • 57.19 (n)
  • 52.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2378 36
zebrafish
(Danio rerio)
Actinopterygii tpx2 37
  • 46 (a)
OneToOne
wufa12d08 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10570 37
  • 34 (a)
OneToOne
Species with no ortholog for TPX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPX2 Gene

ENSEMBL:
Gene Tree for TPX2 (if available)
TreeFam:
Gene Tree for TPX2 (if available)

Paralogs for TPX2 Gene

Selected SIMAP similar genes for TPX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPX2: view

No data available for Paralogs for TPX2 Gene

Variants for TPX2 Gene

Sequence variations from dbSNP and Humsavar for TPX2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs723906 -- 31,786,916(-) AAATC(C/G)TATCA intron-variant
rs1062794 -- 31,793,955(+) TTCTC(C/G)TTTGA synonymous-codon, reference
rs1075698 -- 31,800,189(+) ATTTA(C/G)GAGAC intron-variant
rs2149282 -- 31,751,342(+) GAAGC(C/G)TTCCC intron-variant
rs2182967 -- 31,751,582(+) AGTAG(C/G)TTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPX2 Gene

Variant ID Type Subtype PubMed ID
nsv3346 CNV Insertion 18451855

Relevant External Links for TPX2 Gene

HapMap Linkage Disequilibrium report
TPX2

Disorders for TPX2 Gene

(1) University of Copenhagen DISEASES for TPX2 Gene

(9) Novoseek inferred disease relationships for TPX2 Gene

Disease -log(P) Hits PubMed IDs
precancerous lesions 35.4 2
cancer 27.4 1
tumors 26.1 15
pancreatic cancer 20 9
cancer lung 8.9 3

Relevant External Links for TPX2

Genetic Association Database (GAD)
TPX2
Human Genome Epidemiology (HuGE) Navigator
TPX2
genes like me logo Genes that share disorders with TPX2: view

No data available for UniProtKB/Swiss-Prot for TPX2 Gene

Publications for TPX2 Gene

  1. Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PMID: 10393424) Zhang Y. … Parwaresch R. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PMID: 9207457) Heidebrecht H.J. … Parwaresch R. (Blood 1997) 2 3 4 23
  3. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PMID: 10512675) Manda R. … Yokota J. (Genomics 1999) 3 4 23
  4. TPX2, a novel Xenopus MAP involved in spindle pole organization. (PMID: 10871281) Wittmann T. … Vernos I. (J. Cell Biol. 2000) 3 4 23
  5. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. (PMID: 14580337) Bayliss R. … Conti E. (Mol. Cell 2003) 3 4 23

Products for TPX2 Gene

  • Addgene plasmids for TPX2

Sources for TPX2 Gene

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