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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TPX2 Gene

protein-coding GIFtS: 59
GCID: GC20P030326

TPX2, microtubule-associated, homolog (Xenopus laevis)

(Previous name: chromosome 20 open reading frame 1 )
(Previous symbols: C20orf2, C20orf1)

Explore 20 diseases affiliated with
TPX2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TPX2, Microtubule-Associated, Homolog (Xenopus Laevis)¹ ²		Chromosome 20 Open Reading Frame 1¹
C20orf1¹ ² ³ ⁵		FLS353²
C20orf2¹ ² ³		GD:C20orf1²
DIL-2¹ ² ³		HCTP4²
P100⁵		REPP86²
Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2² ³		Differentially Expressed In Lung Cells²
Hepatocellular Carcinoma-Associated Antigen 519² ³		Preferentially Expressed In Colorectal Cancer²
Protein Fls353² ³		Restricted Expression Proliferation Associated Protein 100²
Restricted Expression Proliferation-Associated Protein 100² ³		Targeting Protein For Xklp2²
DIL2² ³		TPX2, Microtubule-Associated Protein Homolog²
HCA519² ³		P100⁵

External Ids:	HGNC: 1249¹	Entrez Gene: 22974²	Ensembl: ENSG00000088325⁷	OMIM: 605917⁵	UniProtKB: Q9ULW0³

Export aliases for TPX2 gene to outside databases

Previous GC identifers: GC20P031024 GC20P031072 GC20P031071 GC20P029790 GC20P027115

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0

Function: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of

microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates

AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and

protects this residue against dephosphorylation

Gene Wiki entry for TPX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TPX2 gene promoter:
E2F-4 E2F-3a E2F-5 Lmo2 E2F-2 SREBP-1a E2F E2F-1 Sox9 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TPX2 promoter sequence

Search SABiosciences Chromatin IP Primers for TPX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.2

TPX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPX2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P030326: view genomic region (about GC identifiers)

Start:	30,326,904 bp from pter	End:	30,389,608 bp from pter
Size:	62,705 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0 (See protein sequence)

Recommended Name: Targeting protein for Xklp2

Size: 747 amino acids; 85653 Da

Subunit: Interacts with AURKA

Subcellular location: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During

mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is

diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on

apoptotic microtubules

Developmental stage: Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis

3 PDB 3D structures from and Proteopedia for TPX2:

1OL5 (3D)

3E5A (3D)

3HA6 (3D)

Secondary accessions: Q9H1R4 Q9NRA3 Q9UFN9 Q9UL00 Q9Y2M1

Explore the universe of human proteins at neXtProt for TPX2: NX_Q9ULW0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULW0

TPX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036244.2

ENSEMBL proteins:

ENSP00000300403 ENSP00000341145

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals TPX2 Protein Novus Biologicals TPX2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TPX2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	colocalizes with spindle pole	IDA	14718566
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--
GO:0005819	spindle	ISS	18663142

TPX2 for ontologies About GeneDecksing

TPX2 Antibody Products:

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	ThermoFisher Antibody for TPX2

Assay Products for TPX2:

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	GenScript Custom Assay Services for TPX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TPX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TPX2 for domains About GeneDecksing

3 InterPro domains/families:

IPR015128 Aurora-A-bd

IPR022021 TPX2_importin

IPR009675 Xklp2_targeting_prot

Graphical View of Domain Structure for InterPro Entry Q9ULW0

ProtoNet protein and cluster: Q9ULW0

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0

Similarity: Belongs to the TPX2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0

Function: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of

microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates

AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and

protects this residue against dephosphorylation

miRNA Products:		OriGene 3'-UTR Clone: TPX2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPX2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TPX2:
		hsa-miR-4294 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: TPX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPX2 (see all 7) OriGene shRNA RFP: TPX2 OriGene siRNA: TPX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPX2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TPX2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPX2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPX2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPX2 (NM_012112)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TPX2
		Search LifeMap BioReagents cell lines for TPX2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPX2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17474147
GO:0005524	ATP binding	TAS	10512675
GO:0005525	GTP binding	TAS	10512675
GO:0019901	protein kinase binding	IPI	19801554

TPX2 for ontologies About GeneDecksing

9 GenomeRNAi human phenotypes for TPX2:

Abundance of large cells with	Cell cycle / mitosis defect	Cell division defect	Decreased cell number, increas
Decreased homologous recombina	Increased cell number in G2M,	Increased gamma-H2AX phosphory	Increased number of mitotic ce
Synthetic lethal with c-Myc af

Animal Models:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tpx2):

cellular	embryogenesis	endocrine/exocrine gland	hematopoietic system	immune system
mortality/aging	nervous system	tumorigenesis

TPX2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

PLK1 signaling events

PLK1 signaling events

1.00

Aurora A signaling

Aurora A signaling

1.00

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TPX2

Cell cycle Spindle assembly and chromosome separation

1 Cell Signaling Technology (CST) Pathway for TPX2

Cell Cycle / Checkpoint Control

1 GeneGo (Thomson Reuters) Pathway for TPX2

Cell cycle Spindle assembly and chromosome separation

2 BioSystems Pathways for TPX2

	PLK1 signaling events
	Aurora A signaling

TPX2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TPX2

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/544 Interacting proteins for TPX2 (Q9ULW0^{1, 2, 3} ENSP00000300403⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 544)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹^,³, ENSP00000339007⁴	EBI-1037322,EBI-401755 I2D: score=2 STRING: ENSP00000339007
KPNB1	Q14974²^,³, ENSP00000290158⁴	MINT-7947479 I2D: score=1 STRING: ENSP00000290158
PIK3R1	P27986¹^,²^,³, ENSP00000274335⁴	EBI-1037322,EBI-79464 MINT-8112327 I2D: score=3 STRING: ENSP00000274335
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1037322,EBI-3448658 I2D: score=2 STRING: ENSP00000288986
AURKA	O14965³, ENSP00000216911⁴	I2D: score=4 STRING: ENSP00000216911

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007067	mitosis	IEA	--
GO:0008283	cell proliferation	TAS	10512675
GO:0032147	activation of protein kinase activity	IDA	19801554
GO:0051301	cell division	IEA	--

TPX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TPX2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TPX2
3 Novoseek chemical compound relationships for TPX2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	21.3	5	11163242 (3), 15385625 (1)
serine	8.97	1	12612055 (1)
atp	0	2	17705509 (2)

Search CenterWatch for drugs/clinical trials and news about TPX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TPX2 gene:

NM_012112.4

Unigene Cluster for TPX2:

TPX2, microtubule-associated, homolog (Xenopus laevis)

Hs.244580 [show with all ESTs]

Unigene Representative Sequence: NM_012112

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000300403(uc002wwp.1) ENST00000340513(uc010gdv.1)

miRNA Products:		OriGene 3'-UTR Clone: TPX2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPX2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TPX2:
		hsa-miR-4294 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: TPX2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPX2 (see all 7) OriGene shRNA RFP: TPX2 OriGene siRNA: TPX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPX2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPX2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPX2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TPX2 (NM_012112)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPX2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPX2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPX2

Additional cDNA sequence:

AB024704.1 AB027467.1 AF098158.1 AF146731.1 AF244547.1 AF287265.1 AK001391.1 AK093379.1

AK312549.1 AL117534.1 AY734680.1 BC004136.1 BC011357.1 BC020207.1

18 DOTS entries:

DT.443579 DT.92408694 DT.100656693 DT.100046396 DT.100656685 DT.120812883 DT.100046298 DT.120812874

DT.120812962 DT.100656694 DT.120812952 DT.75100798 DT.95363940 DT.100871644 DT.91763912 DT.95363935

DT.95277878 DT.95277896

24/462 AceView cDNA sequences (see all 462):

BP365042 AW955262 CA422124 BU542883 AY734680 BI868955 AA279210 CA441377

BM468856 BQ924361 CR597329 BE871603 AI824928 BM834247 BQ962812 AW674890

AF146731 BM542942 CR593407 AB027467 BC004136 BU633219 BM789690 AA809459

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TPX2 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^
SP1:																	-								-		-				-
SP2:																	-								-		-				-
SP3:
SP4:
SP5:																															-

ExUns:	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23a	·	23b
SP1:									-
SP2:	-								-
SP3:
SP4:									-										-
SP5:

ECgene alternative splicing isoforms for TPX2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TPX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGCCTCA

About this image

TPX2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

S-shaped Body

Kidney Endothelial Cells

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See TPX2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPX2

SOURCE GeneReport for Unigene cluster: Hs.244580

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0

Tissue specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues

SABiosciences Custom PCR Arrays for TPX2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPX2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPX2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPX2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPX2 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tpx2^{1 , 5}	TPX2, microtubule-associated protein homolog (Xenopus more^{1, 5}	82.39(n)¹ 79.86(a)¹		2 (75.41 cM)⁵ 72119¹ NM_028109.4¹ NP_082385.3¹ 152847978⁵
chicken (Gallus gallus)	Aves	TPX2¹	TPX2, microtubule-associated, homolog (Xenopus laevis)	65.47(n) 59.61(a)		395081 NM_204437.1 NP_989768.1
lizard (Anolis carolinensis)	Reptilia	TPX2⁶	--	53(a)	1 ↔ 1	GL343768.1(52353-81592)
African clawed frog (Xenopus laevis)	Amphibia	TPX2²	targeting protein for Xklp2	72.7(n)		AF244546.1
zebrafish (Danio rerio)	Actinopterygii	wufa12d08²	wufa12d08	73.89(n)		335050 BI850044.1
honey bee (Apis mellifera)	Insecta	--	--	16(a)	1 ↔ 1	Group8.16(601869-603911)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G44270⁶ TPX2⁶	targeting protein for XKLP2	16(a) 15(a)	many → 1 many → 1	5(17833636-17835740) 1(947520-951827)
rice (Oryza sativa)	Liliopsida	--	targeting protein-related, putative, expressed	18(a)	1 ↔ 1	7(19251855-19257025)

ENSEMBL Gene Tree for TPX2 (if available)
TreeFam Gene Tree for TPX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188262552^1,2		--	30324911(+)	`CTCTGC/TCGCCC`	1	--	us2k¹		0	--	--	--	--
rs113444994^1,2	C,	--	30325052(+)	`TCATAG/CAAGAG`	1	--	us2k¹		1		NA	2
rs180952168^1,2		--	30325209(+)	`TCCCTA/GCCGTA`	1	--	us2k¹		0	--	--	--	--
rs151256349^1,2		--	30325427(+)	`CGGGTA/CCTTGG`	1	--	us2k¹		0	--	--	--	--
rs186173021^1,2		--	30325447(+)	`GCAGGA/TGAAAC`	1	--	us2k¹		0	--	--	--	--
rs6087774^1,2	C,A,H,	--	30325607(+)	`aggaaC/Ataaat`	1	--	us2k¹		7		NS EA NA	600
rs181526187^1,2		--	30325712(+)	`TAATAA/TGTACA`	1	--	us2k¹		0	--	--	--	--
rs17093560^1,2	C,F,H,	--	30325713(+)	`AATATG/ATACAA`	1	--	us2k¹ tfbs³		15		NA NS EA	1692
rs6060912^1,2	C,F,A,H,	--	30325755(+)	`AAATTC/AAAGAT`	1	--	us2k¹		10		NS EA NA WA	652
rs6087775^1,2	C,F,A,	--	30325765(+)	`TGCCAG/ATACTT`	1	--	us2k¹		10		NA WA CSA EA	371

HapMap Linkage Disequilibrium report for TPX2 (30326904 - 30389608 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPX2: --

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing TPX2:

Ovarian Cancer

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TPX2 for disorders           About GeneDecksing

OMIM gene information: 605917    OMIM disorders: --

20 diseases for TPX2:    About MalaCards

hepatocellular carcinoma colorectal cancer carcinoma squamous cell carcinoma

oral squamous cell carcinoma mantle cell lymphoma renal cell carcinoma giant cell tumor

lung squamous cell carcinoma multiple myeloma pancreatic cancer myeloma

cervical cancer cervicitis pancreatitis ovarian cancer

lung carcinoma lung cancer astrocytoma breast cancer

9 Novoseek disease relationships for TPX2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
precancerous lesions	35.4	2	17134548 (2)
cancer	27.4	1	9207457 (1)
tumors	26.1	18	17134548 (5), 19861455 (2), 18497064 (2), 17483353 (2) (see all 8)
pancreatic cancer	20	10	19861455 (8), 16532023 (1)
cancer lung	8.9	4	16489064 (2), 15983384 (1)
hepatocellular carcinoma	4.24	3	11746524 (1), 16631581 (1)
carcinoma squamous cell	0.636	3	17134548 (2), 16489064 (1)
dysplasia	0	3	17134548 (1), 16489064 (1)
carcinoma	0	9	19148505 (4), 18723071 (1), 16489064 (1)

Human Genome Epidemiology (HuGE) Navigator: TPX2 (2 documents)

Export disorders for TPX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TPX2 gene, integrated from 9 sources (see all 117):
(articles sorted by number of sources associating them with TPX2)

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world of online information

p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PubMed id 9207457)^{1, 2, 3, 9} Heidebrecht H.J....Parwaresch R. (1997)
Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PubMed id 10393424)^{1, 2, 3, 9} Zhang Y....Parwaresch R. (1999)
TPX2, a novel Xenopus MAP involved in spindle pole organization. (PubMed id 10871281)^{1, 2, 9} Wittmann T.... Vernos I. (2000)
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. (PubMed id 14580337)^{1, 2, 9} Bayliss R.... Conti E. (2003)
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. (PubMed id 18663142)^{1, 2, 9} Bird A.W. and Hyman A.A. (2008)
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. (PubMed id 18662907)^{1, 2, 9} Zhao B.... Lai Z. (2008)
Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)^{1, 2, 9} Manda R.... Yokota J. (1999)
Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. (PubMed id 19208764)^{1, 2, 9} Moss D.K.... Lane J.D. (2009)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22974	HGNC: 1249	AceView: TPX2	Ensembl:ENSG00000088325	euGenes: HUgn22974
ECgene: TPX2	H-InvDB: TPX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TPX2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TPX2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TPX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TPX2 gene:
Search GeneIP for patents involving TPX2

GeneCards and IP:
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TPX2, microtubule-associated, homolog (Xenopus laevis)

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TPX2 (Gene Symbol)
TPX2, Microtubule-Associated, Homolog (Xenopus Laevis)
C20orf1
C20orf2
DIL-2
P100
Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2
Hepatocellular Carcinoma-Associated Antigen 519
Protein Fls353
Restricted Expression Proliferation-Associated Protein 100
DIL2
HCA519
Chromosome 20 Open Reading Frame 1
FLS353
GD:C20orf1
HCTP4
REPP86
Differentially Expressed In Lung Cells
Preferentially Expressed In Colorectal Cancer
Restricted Expression Proliferation Associated Protein 100
Targeting Protein For Xklp2
TPX2, Microtubule-Associated Protein Homolog
P100

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TPX2 Gene

TPX2, microtubule-associated, homolog (Xenopus laevis)

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