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TPX2 Gene

protein-coding   GIFtS: 63
GCID: GC20P030326

TPX2, Microtubule-Associated

(Previous names: chromosome 20 open reading frame 1, TPX2, microtubule-associated,...)
(Previous symbols: C20orf2, C20orf1)
  See TPX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TPX2, Microtubule-Associated1 2     TPX2, Microtubule-Associated, Homolog (Xenopus Laevis)1
C20orf11 2 3 5     FLS3532
C20orf21 2 3     GD:C20orf12
Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 22 3     HCTP42
Hepatocellular Carcinoma-Associated Antigen 5192 3     REPP862
Protein Fls3532 3     Differentially Expressed In Lung Cells2
Restricted Expression Proliferation-Associated Protein 1002 3     Preferentially Expressed In Colorectal Cancer2
DIL-22 3     Restricted Expression Proliferation Associated Protein 1002
DIL22 3     Targeting Protein For Xklp22
HCA5192 3     TPX2, Microtubule-Associated Protein Homolog2
p1002 3     TPX2, Microtubule-Associated, Homolog2
Chromosome 20 Open Reading Frame 11     P1005

External Ids:    HGNC: 12491   Entrez Gene: 229742   Ensembl: ENSG000000883257   OMIM: 6059175   UniProtKB: Q9ULW03   

Export aliases for TPX2 gene to outside databases

Previous GC identifers: GC20P031024 GC20P031072 GC20P031071 GC20P029790 GC20P027115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPX2 Gene:
TPX2 (TPX2, microtubule-associated) is a protein-coding gene. Diseases associated with TPX2 include hepatocellular carcinoma, and colorectal cancer. GO annotations related to this gene include protein kinase binding and GTP binding.

UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0
Function: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly
of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation.
Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at
'Thr-288' and protects this residue against dephosphorylation

Gene Wiki entry for TPX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPX2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   E2F-2   SREBP-1a   E2F   E2F-1   Sox9   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPX2 promoter sequence
   Search Chromatin IP Primers for TPX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.2

TPX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPX2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030326:  view genomic region     (about GC identifiers)

Start:
30,326,904 bp from pter      End:
30,389,608 bp from pter
Size:
62,705 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0 (See protein sequence)
Recommended Name: Targeting protein for Xklp2  
Size: 747 amino acids; 85653 Da
Subunit: Interacts with AURKA
Developmental stage: Exclusively expressed in proliferating cells from the transition G1/S until the end of
cytokinesis
3 PDB 3D structures from and Proteopedia for TPX2:
1OL5 (3D)        3E5A (3D)        3HA6 (3D)    
Secondary accessions: Q9H1R4 Q9NRA3 Q9UFN9 Q9UL00 Q9Y2M1

Explore the universe of human proteins at neXtProt for TPX2: NX_Q9ULW0

Explore proteomics data for TPX2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys48, Lys75, Lys524, Lys567
  • Modification sites at PhosphoSitePlus

  • See TPX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036244.2  
    ENSEMBL proteins: 
     ENSP00000300403   ENSP00000341145  

    TPX2 Human Recombinant Protein Products:

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    antibodies-online proteins for TPX2 (4 products) 

     
    antibodies-online peptides for TPX2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR015128 Aurora-A-bd
     IPR027329 TPX2_dom_C
     IPR009675 TPX2_fam
     IPR027330 TPX2_central_dom

    Graphical View of Domain Structure for InterPro Entry Q9ULW0

    ProtoNet protein and cluster: Q9ULW0

    UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0
    Similarity: Belongs to the TPX2 family


    Find genes that share domains with TPX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPX2_HUMAN, Q9ULW0
    Function: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly
    of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation.
    Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at
    'Thr-288' and protects this residue against dephosphorylation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0005524ATP binding TAS10512675
    GO:0005525GTP binding TAS10512675
    GO:0019901protein kinase binding IPI14580337
         
    Find genes that share ontologies with TPX2           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for TPX2:
     Abundance of large cells with   Cell cycle / mitosis defect  Cell division defect  Decreased cell number, increas 
     Decreased homologous recombina  Increased cell number in G2M,   Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with c-Myc af 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tpx2):
     cellular  embryogenesis  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging  nervous system  tumorigenesis 

    Find genes that share phenotypes with TPX2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TPX2

    miRNA
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    miRTarBase miRNAs that target TPX2:
    hsa-mir-193b-3p (MIRT041448)

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    hsa-miR-4294 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTPX2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPX2_HUMAN, Q9ULW0: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
    Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during
    S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and
    is detected on apoptotic microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922colocalizes with spindle pole IDA14718566
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0005819spindle ISS18663142

    Find genes that share ontologies with TPX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    2PLK1 signaling events
    PLK1 signaling events
    3Gastric cancer network 1
    Gastric cancer network 1
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation
    5Aurora A signaling
    Aurora A signaling


    Find genes that share SuperPaths with TPX2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TPX2
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for TPX2
        Cell cycle Spindle assembly and chromosome separation

    3 BioSystems Pathways for TPX2
        Gastric cancer network 1
    Aurora A signaling
    PLK1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPX2
    Interactions:

        GeneGlobe Interaction Network for TPX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for TPX2 (Q9ULW01, 2, 3 ENSP000003004034) via UniProtKB, MINT, STRING, and/or I2D (see all 571)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629931, 3, ENSP000003390074EBI-1037322,EBI-401755 I2D: score=2 STRING: ENSP00000339007
    KPNB1Q149742, 3, ENSP000002901584MINT-7947479 I2D: score=1 STRING: ENSP00000290158
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-1037322,EBI-79464 MINT-8112327 I2D: score=3 STRING: ENSP00000274335
    NCK1P163331, 3, ENSP000002889864EBI-1037322,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    AURKAO149653, ENSP000002169114I2D: score=4 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007067mitosis IEA--
    GO:0008283cell proliferation TAS10512675
    GO:0032147activation of protein kinase activity IDA14580337
    GO:0060236regulation of mitotic spindle organization ISS18663142

    Find genes that share ontologies with TPX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPX2

    3 Novoseek inferred chemical compound relationships for TPX2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 21.3 5 11163242 (3), 15385625 (1)
    serine 8.97 1 12612055 (1)
    atp 0 2 17705509 (2)



    Find genes that share compounds with TPX2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPX2 gene: 
    NM_012112.4  

    Unigene Cluster for TPX2:

    TPX2, microtubule-associated, homolog (Xenopus laevis)
    Hs.244580  [show with all ESTs]
    Unigene Representative Sequence: NM_012112
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300403(uc002wwp.1) ENST00000340513(uc010gdv.1)
    miRNA
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    Additional mRNA sequence: 

    AB024704.1 AB027467.1 AF098158.1 AF146731.1 AF244547.1 AF287265.1 AK001391.1 AK093379.1 
    AK312549.1 AL117534.1 AY734680.1 BC004136.1 BC011357.1 BC020207.1 

    18 DOTS entries:

    DT.443579  DT.92408694  DT.100656693  DT.100046396  DT.100656685  DT.120812883  DT.100046298  DT.120812874 
    DT.120812962  DT.100656694  DT.120812952  DT.75100798  DT.95363940  DT.100871644  DT.91763912  DT.95363935 
    DT.95277878  DT.95277896 

    Selected AceView cDNA sequences (see all 462):

    BP357668 BP431016 AW513669 AI950056 CA441292 BM991945 CR597329 CA430497 
    BQ065591 BQ049032 BC020207 BM835912 CB146058 BG114981 BM797526 BM917624 
    BM744543 AF244547 BM786319 CA422124 BQ921100 BM766565 BE616180 BQ943419 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPX2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                                                  -                       -     -           -                                                               
    SP2:                                                  -                       -     -           -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                            -                                                               

    ExUns: 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b
    SP1:                          -                                                   
    SP2:  -                       -                                                   
    SP3:                                                                              
    SP4:                          -                             -                     
    SP5:                                                                              


    ECgene alternative splicing isoforms for TPX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGCCTCA
    TPX2 Expression
    About this image


    TPX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Umbilical cord blood-derived mesenchymal stem cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    TPX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.244580

    UniProtKB/Swiss-Prot: TPX2_HUMAN, Q9ULW0
    Tissue specificity: Expressed in lung carcinoma cell lines but not in normal lung tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TPX2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpx21 , 5 TPX2, microtubule-associated protein homolog (Xenopus more1, 5 82.19(n)1
    79.62(a)1
      2 (75.41 cM)5
    721191  NM_028109.41  NP_082385.31 
     1528479785 
    chicken
    (Gallus gallus)
    Aves TPX21 TPX2, microtubule-associated, homolog (Xenopus laevis) 65.47(n)
    59.61(a)
      395081  NM_204437.1  NP_989768.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPX26
    TPX2, microtubule-associated
    54(a)
    1 ↔ 1
    GL343768.1(51820-96643)
    African clawed frog
    (Xenopus laevis)
    Amphibia TPX22 targeting protein for Xklp2 72.7(n)    AF244546.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12d082 wufa12d08 73.89(n)   335050  BI850044.1 


    ENSEMBL Gene Tree for TPX2 (if available)
    TreeFam Gene Tree for TPX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPX2 gene
    2 SIMAP similar genes for TPX2 using alignment to 2 protein entries:     TPX2_HUMAN (see all proteins):
    HCTP4    HCA90

    Find genes that share paralogs with TPX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPX2 (see all 1209)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362694
    A colorectal cancer sample4--see VAR_0362692 T N mis40--------
    rs1882625521,2
    C--30324911(+) CTCTGC/TCGCCC 1 -- us2k10--------
    rs130448081,2
    C--30324964(+) tgcctC/G/Tctggg 1 -- us2k10--------
    rs1134449941,2
    C,F--30325052(+) TCATAG/CAAGAG 1 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1809521681,2
    --30325209(+) TCCCTA/GCCGTA 1 -- us2k10--------
    rs1512563491,2
    --30325427(+) CGGGTA/CCTTGG 1 -- us2k10--------
    rs1861730211,2
    --30325447(+) GCAGGA/TGAAAC 1 -- us2k10--------
    rs60877741,2
    C,F,A,H--30325607(+) aggaaC/Ataaat 1 -- us2k17Minor allele frequency- A:0.00NS EA NA 600
    rs1815261871,2
    --30325712(+) TAATAA/TGTACA 1 -- us2k10--------
    rs170935601,2
    C,F,H--30325713(+) AATATG/ATACAA 1 -- us2k1 tfbs315Minor allele frequency- A:0.09NA NS EA 1692

    HapMap Linkage Disequilibrium report for TPX2 (30326904 - 30389608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TPX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3346CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TPX2:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing TPX2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605917    OMIM disorders: --

    2 diseases for TPX2:    
    About MalaCards
    hepatocellular carcinoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for TPX2:
    Renal cell carcinoma

    Find genes that share disorders with TPX2           About GenesLikeMe

    9 Novoseek inferred disease relationships for TPX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    precancerous lesions 35.4 2 17134548 (2)
    cancer 27.4 1 9207457 (1)
    tumors 26.1 18 17134548 (5), 19861455 (2), 18497064 (2), 17483353 (2) (see all 8)
    pancreatic cancer 20 10 19861455 (8), 16532023 (1)
    cancer lung 8.9 4 16489064 (2), 15983384 (1)
    hepatocellular carcinoma 4.24 3 11746524 (1), 16631581 (1)
    carcinoma squamous cell 0.636 3 17134548 (2), 16489064 (1)
    dysplasia 0 3 17134548 (1), 16489064 (1)
    carcinoma 0 9 19148505 (4), 18723071 (1), 16489064 (1)

    Genetic Association Database (GAD): TPX2
    Human Genome Epidemiology (HuGE) Navigator: TPX2 (2 documents)

    Export disorders for TPX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPX2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with TPX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. (PubMed id 9207457)1, 2, 3, 9 Heidebrecht H.J....Parwaresch R. (Blood 1997)
    2. Assignment of human proliferation associated p100 gene (C20orf1) to human chromosome band 20q11.2 by in situ hybridization. (PubMed id 10393424)1, 2, 3, 9 Zhang Y.... Parwaresch R. (Cytogenet. Cell Genet. 1999)
    3. TPX2, a novel Xenopus MAP involved in spindle pole organization. (PubMed id 10871281)1, 2, 9 Wittmann T.... Vernos I. (J. Cell Biol. 2000)
    4. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. (PubMed id 14580337)1, 2, 9 Bayliss R.... Conti E. (Mol. Cell 2003)
    5. Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. (PubMed id 18663142)1, 2, 9 Bird A.W. and Hyman A.A. (J. Cell Biol. 2008)
    6. Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2. (PubMed id 18662907)1, 2, 9 Zhao B.... Lai Z. (Protein Sci. 2008)
    7. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)1, 2, 9 Manda R.... Yokota J. (Genomics 1999)
    8. Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase. (PubMed id 19208764)1, 2, 9 Moss D.K.... Lane J.D. (J. Cell Sci. 2009)
    9. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22974 HGNC: 1249 AceView: TPX2 Ensembl:ENSG00000088325 euGenes: HUgn22974
    ECgene: TPX2 H-InvDB: TPX2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TPX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TPX2 gene:
    Search GeneIP for patents involving TPX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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