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TPTE2 Gene

protein-coding   GIFtS: 50
GCID: GC13M019997

Transmembrane Phosphoinositide 3-Phosphatase And Tensin...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 21 2     Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase TPTE22
Lipid Phosphatase TPIP2 3     PTEN-Like Inositol Lipid Phosphatase2
TPIP2 3     TPIP Lipid Phosphatase2
TPTE And PTEN Homologous Inositol Lipid Phosphatase2 3     EC 3.1.3.673
Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase TPTE22     

External Ids:    HGNC: 172991   Entrez Gene: 934922   Ensembl: ENSG000001329587   OMIM: 6067915   UniProtKB: Q6XPS33   
ORGUL members:         

Export aliases for TPTE2 gene to outside databases

Previous GC identifers: GC13M017796 GC13M018895 GC13M000801


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPTE2 Gene:
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the
3-position phosphate of inositol phospholipids.(supplied by OMIM, Jul 2002)

GeneCards Summary for TPTE2 Gene:
TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2) is a protein-coding gene. Diseases associated with TPTE2 include hepatocellular carcinoma, and prostate cancer. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is DNAJC6.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPTE2 gene promoter:
         SRY   NF-kappaB2   RelA   NF-kappaB   NF-kappaB1   LyF-1   C/EBPalpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPTE2 promoter sequence
   Search Chromatin IP Primers for TPTE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPTE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

TPTE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPTE2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M019997:  view genomic region     (about GC identifiers)

Start:
19,997,017 bp from pter      End:
20,110,903 bp from pter
Size:
113,887 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2  
Size: 522 amino acids; 61112 Da
Secondary accessions: A1A4X0 A1A4X1 A8MX64 B1AQ16 Q5VUH2 Q8WWL4 Q8WWL5
Alternative splicing: 6 isoforms:  Q6XPS3-1   Q6XPS3-2   Q6XPS3-3   Q6XPS3-4   Q6XPS3-5   Q6XPS3-6   (Expressed in testis, strongly inhibits cell growth in HeLa cells)

Explore the universe of human proteins at neXtProt for TPTE2: NX_Q6XPS3

Explore proteomics data for TPTE2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TPTE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135440.1  NP_001258779.1  NP_570141.3  NP_954863.2  

    ENSEMBL proteins: 
     ENSP00000372438   ENSP00000432402   ENSP00000375098   ENSP00000382974   ENSP00000383089  
     ENSP00000255310   ENSP00000372437   ENSP00000372435   ENSP00000442218  
    Reactome Protein details: Q6XPS3

    TPTE2 Human Recombinant Protein Products:

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    TPTE2 Assay Products:

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    Cloud-Clone Corp. CLIAs for TPTE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    Selected InterPro protein domains (see all 6):
     IPR014019 Phosphatase_tensin-typ
     IPR016130 Tyr_Pase_AS
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR005821 Ion_trans_dom
     IPR014020 Tensin_phosphatase_C2-dom

    Graphical View of Domain Structure for InterPro Entry Q6XPS3

    ProtoNet protein and cluster: Q6XPS3

    UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain


    TPTE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPTE2_HUMAN, Q6XPS3
    Catalytic activity: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate +
    phosphate

         Enzyme Number (IUBMB): EC 3.1.3.671

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005216ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA--
         
    TPTE2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TPTE2:
     Increased HPV18 LCR reporter a  Increased apoptosis 

         1 MGI phenotypic allele for Tpte (no phenotypes)

    TPTE2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tptetm1Lex for TPTE2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPTE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPTE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPTE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPTE2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPTE2:
    hsa-mir-148b-3p (MIRT019346)

    Block miRNA regulation of human, mouse, rat TPTE2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TPTE2
    SwitchGear 3'UTR luciferase reporter plasmidTPTE2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPTE2 (NM_199254)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPTE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPTE2_HUMAN, Q6XPS3: Endoplasmic reticulum membrane; Multi-pass membrane protein
    TPTE2_HUMAN, Q6XPS3: Isoform 4: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus4
    plasma membrane3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    TPTE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPTE2 About    
    See pathways by source

    SuperPathContained pathways About
    1PI Metabolism
    PI Metabolism0.65
    Synthesis of PIPs at the Golgi membrane0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64
    43-phosphoinositide degradation
    3-phosphoinositide degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TPTE2
        3-phosphoinositide degradation

    1 Reactome Pathway for TPTE2
        Synthesis of PIPs at the Golgi membrane



    TPTE2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPTE2
    Interactions:

        Search GeneGlobe Interaction Network for TPTE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for TPTE2 (ENSP000003830894) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTORENSP000003545584STRING: ENSP00000354558
    AFF4ENSP000002653434STRING: ENSP00000265343
    TSC1ENSP000002985524STRING: ENSP00000298552
    IRS1ENSP000003048954STRING: ENSP00000304895
    IRS2ENSP000003650164STRING: ENSP00000365016
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006811ion transport ----
    GO:0016311dephosphorylation ----

    TPTE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPTE2

    Selected HMDB Compounds for TPTE2 (see all 380)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TPTE2 gene (5 alternative transcripts): 
    NM_199255.1  NM_001141968.1  NM_001271850.1  NM_130785.3  NM_199254.2  

    Unigene Cluster for TPTE2:

    Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
    Hs.377488  [show with all ESTs]
    Unigene Representative Sequence: NR_073485
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382978(uc010tcl.2 uc009zzk.3 uc001ume.3 uc009zzm.3)
    ENST00000462409 ENST00000390680 ENST00000400103(uc009zzl.3) ENST00000400230(uc001umd.3 uc010tcm.2)
    ENST00000255310 ENST00000382977 ENST00000382975 ENST00000457266
    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPTE2 (NM_199254)
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    Additional mRNA sequence: 

    AJ421032.1 AJ421033.1 AK301741.1 AY219890.1 BC128146.1 BC128147.1 FJ969729.1 NR_073485.1 
    NR_073486.1 NR_073487.1 

    2 DOTS entries:

    DT.101981716  DT.40106613 

    16 AceView cDNA sequences:

    BI061602 BI063797 AJ421033 BG207812 AL079581 NM_199254 AY219890 AL079582 
    NM_130785 AW393549 NM_199255 AJ421032 BG200515 BG206253 BF092239 BG187093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPTE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCTAAGT
    TPTE2 Expression
    About this image

    TPTE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPTE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377488

    UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3
    Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be
    testis-specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPTE2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpte1 , 5 transmembrane phosphatase with tensin homology1, 5 75.33(n)1
    67.42(a)1
      8 (11.20 cM)5
    2341291  NM_199257.21  NP_954866.21 
     222834415 
    chicken
    (Gallus gallus)
    Aves TPTE21 transmembrane phosphoinositide 3-phosphatase and tensin more 64.37(n)
    59.48(a)
      418885  XM_004938738.1  XP_004938795.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    59(a)
    53(a)
    many ↔ many
    many ↔ many
    GL343260.1(1399329-1400123)
    1(132594652-132629594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100392 Xenopus laevis transcribed sequence with weak similarity more 76.42(n)    BQ727249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tpte1 transmembrane phosphatase with tensin homology 60.29(n)
    55.65(a)
      327292  NM_001025458.1  NP_001020629.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-256
    Protein DNJ-25, isoform a (dnj-25) mRNA, complete ...
    7(a)
    many ↔ many
    V(20729948-20744339) WBGene00001043
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTEN11 PTEN1 55.43(n)
    45.71(a)
      833936  NM_123302.3  NP_198756.2 


    ENSEMBL Gene Tree for TPTE2 (if available)
    TreeFam Gene Tree for TPTE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPTE2 gene
    DNAJC62  PTEN2  TNS12  TPTE2  TENC12  GAK2  TNS42  TNS32  
    6 SIMAP similar genes for TPTE2 using alignment to 2 protein entries:     TPTE2_HUMAN (see all proteins):
    TPTE2P1    TPTE    DKFZp434F1622    PTEN2    PTEN    PTENP1

    TPTE2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for TPTE2 (see all 9)
    PGOHUM00000248336 PGOHUM00000248375 PGOHUM00000249945 PGOHUM00000248535 PGOHUM00000248538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPTE2 (see all 2866)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445442411,2
    C--995903(+) ATCTC-/TT/   
       TTTTT
    TTTTT
    6 -- int11NA 2
    rs1508255891,2
    C--19996532(+) TACTT-/ATCTTCAT 7 -- int10--------
    rs1495210811,2
    C--19996533(+) CTTAT-/CCTTCA 7 -- int10--------
    rs1491494581,2
    --19996624(+) TGCTCA/GGAATG 7 -- int10--------
    rs79856211,2
    C--19996763(+) TAAATC/TAGCTT 7 -- int10--------
    rs93194211,2
    C,F,A--19996831(+) AAATAC/TGTAAG 7 -- int13Minor allele frequency- T:0.50NA 6
    rs1900920411,2
    --19996873(+) ATATCC/TCAAGT 7 -- int10--------
    rs24972001,2
    C,H--19996885(+) TTTGCT/CATGAA 7 -- int15Minor allele frequency- C:0.00NA CSA 9
    rs357921501,2
    C--19996973(+) GGAAA-/GTGTGTG 7 -- int12Minor allele frequency- GT:0.00CSA 4
    rs1386737471,2
    C--19997098(+) GACTTA/TGGACA 7 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TPTE2 (19997017 - 20110903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPTE2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747058CNV Deletion23290073
    dgv334e199CNV Deletion23128226
    esv2677314CNV Deletion23128226
    esv2747051CNV Deletion23290073
    nsv950CNV Insertion18451855
    nsv523915CNV Loss19592680
    nsv471122CNV Loss18288195
    nsv428286CNV Loss18775914
    esv26631CNV Loss19812545
    nsv523550CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606791    OMIM disorders: --

    3 diseases for TPTE2:    
    About MalaCards
    hepatocellular carcinoma    prostate cancer    prostatitis


    TPTE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPTE2
    Human Genome Epidemiology (HuGE) Navigator: TPTE2 (2 documents)

    Export disorders for TPTE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPTE2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TPTE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (Nature 2004)
    2. TPIP: a novel phosphoinositide 3-phosphatase. (PubMed id 11716755)1, 2, 3 Walker S.M.... Leslie N.R. (Biochem. J. 2001)
    3. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PubMed id 14659893)1, 2, 9 Tapparel C.... Antonarakis S.E. (Gene 2003)
    4. A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. (PubMed id 22164291)1, 2 Mishra R.R.... Rath P.C. (PLoS ONE 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The role of PTEN in the progression and survival of prostate cancer. (PubMed id 12717346)1, 3 Deocampo N.D....Tindall D.J. (Minerva Endocrinol. 2003)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)
    8. A human phospholipid phosphatase activated by a transmembrane control module. (PubMed id 22896666)1 Halaszovich C.R....Oliver D. (J. Lipid Res. 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells. (PubMed id 22311048)1 Mishra R.R....Rath P.C. (Mol. Biol. Rep. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 93492 HGNC: 17299 AceView: TPTE2 Ensembl:ENSG00000132958 euGenes: HUgn93492
    ECgene: TPTE2 H-InvDB: TPTE2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TPTE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TPTE2 gene:
    Search GeneIP for patents involving TPTE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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