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Aliases for TPTE2 Gene

Aliases for TPTE2 Gene

  • Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2 2 3 5
  • TPTE And PTEN Homologous Inositol Lipid Phosphatase 3 4
  • Lipid Phosphatase TPIP 3 4
  • TPIP 3 4
  • Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase TPTE2 3
  • PTEN-Like Inositol Lipid Phosphatase 3
  • TPIP Lipid Phosphatase 3
  • EC 4

External Ids for TPTE2 Gene

Previous GeneCards Identifiers for TPTE2 Gene

  • GC13M017796
  • GC13M018895
  • GC13M019997
  • GC13M000801

Summaries for TPTE2 Gene

Entrez Gene Summary for TPTE2 Gene

  • TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

GeneCards Summary for TPTE2 Gene

TPTE2 (Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2) is a Protein Coding gene. Among its related pathways are Metabolism and PI Metabolism. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is TNS1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPTE2 Gene

Genomics for TPTE2 Gene

Regulatory Elements for TPTE2 Gene

Enhancers for TPTE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPTE2 on UCSC Golden Path with GeneCards custom track

Promoters for TPTE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPTE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPTE2 Gene

19,422,877 bp from pter
19,561,574 bp from pter
138,698 bases
Minus strand

Genomic View for TPTE2 Gene

Genes around TPTE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPTE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPTE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPTE2 Gene

Proteins for TPTE2 Gene

  • Protein details for TPTE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
    Protein Accession:
    Secondary Accessions:
    • A1A4X0
    • A1A4X1
    • A8MX64
    • B1AQ16
    • B4DWZ2
    • Q5VUH2
    • Q8WWL4
    • Q8WWL5

    Protein attributes for TPTE2 Gene

    522 amino acids
    Molecular mass:
    61112 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPTE2 Gene

neXtProt entry for TPTE2 Gene

Proteomics data for TPTE2 Gene at MOPED

Post-translational modifications for TPTE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TPTE2 Gene

Domains & Families for TPTE2 Gene

Suggested Antigen Peptide Sequences for TPTE2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 tensin-type domain.
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with TPTE2: view

Function for TPTE2 Gene

Molecular function for TPTE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate.

Enzyme Numbers (IUBMB) for TPTE2 Gene

Gene Ontology (GO) - Molecular Function for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TAS --
genes like me logo Genes that share ontologies with TPTE2: view
genes like me logo Genes that share phenotypes with TPTE2: view

Animal Model Products

CRISPR Products

miRNA for TPTE2 Gene

miRTarBase miRNAs that target TPTE2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPTE2 Gene

Localization for TPTE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPTE2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform 4: Cytoplasm.

Subcellular locations from

Jensen Localization Image for TPTE2 Gene COMPARTMENTS Subcellular localization image for TPTE2 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TPTE2 Gene

Pathways & Interactions for TPTE2 Gene

genes like me logo Genes that share pathways with TPTE2: view

Pathways by source for TPTE2 Gene

Interacting Proteins for TPTE2 Gene

Gene Ontology (GO) - Biological Process for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0006811 ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TPTE2: view

No data available for SIGNOR curated interactions for TPTE2 Gene

Drugs & Compounds for TPTE2 Gene

(382) Additional Compounds for TPTE2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
genes like me logo Genes that share compounds with TPTE2: view

Transcripts for TPTE2 Gene

Unigene Clusters for TPTE2 Gene

Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPTE2 Gene

No ASD Table

Relevant External Links for TPTE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPTE2 Gene

mRNA expression in normal human tissues for TPTE2 Gene

mRNA differential expression in normal tissues according to GTEx for TPTE2 Gene

This gene is overexpressed in Testis (x24.0).

SOURCE GeneReport for Unigene cluster for TPTE2 Gene Hs.377488

mRNA Expression by UniProt/SwissProt for TPTE2 Gene

Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
genes like me logo Genes that share expression patterns with TPTE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TPTE2 Gene

Orthologs for TPTE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPTE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC516736 35
  • 76.29 (n)
  • 63.92 (a)
-- 36
  • 65 (a)
(Canis familiaris)
Mammalia LOC606856 35
  • 79.36 (n)
  • 67.5 (a)
-- 36
  • 48 (a)
(Mus musculus)
Mammalia Tpte 35
  • 75.33 (n)
  • 67.42 (a)
Tpte 16
Tpte 36
  • 50 (a)
(Pan troglodytes)
Mammalia TPTE2 35
  • 99.17 (n)
  • 98.08 (a)
TPTE2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tpte2 35
  • 73.97 (n)
  • 66.73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves TPTE2 35
  • 64.37 (n)
  • 59.48 (a)
-- 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpte2 35
  • 62.51 (n)
  • 56.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10039 35
(Danio rerio)
Actinopterygii tpte 35
  • 60.29 (n)
  • 55.65 (a)
tpte 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea dnj-25 36
  • 7 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTEN1 35
  • 55.43 (n)
  • 45.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for TPTE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPTE2 Gene

Gene Tree for TPTE2 (if available)
Gene Tree for TPTE2 (if available)

Paralogs for TPTE2 Gene

Paralogs for TPTE2 Gene

(6) SIMAP similar genes for TPTE2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPTE2: view

Variants for TPTE2 Gene

Sequence variations from dbSNP and Humsavar for TPTE2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2497218 -, - 19,426,490(+) TAATA(C/T)TTTGT intron-variant, nc-transcript-variant, reference, missense
rs186043 -- 19,563,142(-) gccca(C/G)gctgg upstream-variant-2KB
rs192657 -- 19,550,781(+) CTTTC(C/T)TCCtt intron-variant
rs394651 -- 19,551,938(-) ATCAG(A/T)TAAAC intron-variant
rs403571 -- 19,558,597(+) GCATT(C/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPTE2 Gene

Variant ID Type Subtype PubMed ID
esv2747051 CNV Deletion 23290073
dgv334e199 CNV Deletion 23128226
nsv899851 CNV Gain 21882294
nsv469566 CNV Complex 16826518
nsv428286 CNV Loss 18775914
nsv523881 CNV Gain 19592680
dgv1550n71 CNV Gain 21882294
nsv469567 CNV Complex 16826518
esv26631 CNV Loss 19812545
esv2677314 CNV Deletion 23128226
esv2747058 CNV Deletion 23290073
nsv471122 CNV Loss 18288195
nsv523915 CNV Loss 19592680
nsv899854 CNV Gain 21882294
nsv899855 CNV Gain 21882294
nsv950 CNV Insertion 18451855
nsv523550 CNV Gain 19592680
nsv516945 CNV Gain+Loss 19592680

Variation tolerance for TPTE2 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TPTE2 Gene

Disorders for TPTE2 Gene

Relevant External Links for TPTE2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPTE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPTE2 Gene

Publications for TPTE2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4 67
  2. The role of PTEN in the progression and survival of prostate cancer. (PMID: 12717346) Deocampo N.D. … Tindall D.J. (Minerva Endocrinol. 2003) 2 3
  3. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PMID: 14659893) Tapparel C. … Antonarakis S.E. (Gene 2003) 3 23
  4. TPIP: a novel phosphoinositide 3-phosphatase. (PMID: 11716755) Walker S.M. … Leslie N.R. (Biochem. J. 2001) 2 3
  5. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for TPTE2 Gene

Sources for TPTE2 Gene