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Aliases for TPTE2 Gene

Aliases for TPTE2 Gene

  • Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2 2 3
  • TPTE And PTEN Homologous Inositol Lipid Phosphatase 3 4
  • Lipid Phosphatase TPIP 3 4
  • TPIP 3 4
  • Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase TPTE2 3
  • Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase TPTE2 3
  • PTEN-Like Inositol Lipid Phosphatase 3
  • TPIP Lipid Phosphatase 3
  • EC 3.1.3.67 4

External Ids for TPTE2 Gene

Previous GeneCards Identifiers for TPTE2 Gene

  • GC13M017796
  • GC13M018895
  • GC13M019997
  • GC13M000801

Summaries for TPTE2 Gene

Entrez Gene Summary for TPTE2 Gene

  • TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

GeneCards Summary for TPTE2 Gene

TPTE2 (Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein tyrosine phosphatase activity and ion channel activity. An important paralog of this gene is TNS1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPTE2 Gene

Genomics for TPTE2 Gene

Regulatory Elements for TPTE2 Gene

Genomic Location for TPTE2 Gene

Start:
19,422,877 bp from pter
End:
19,561,574 bp from pter
Size:
138,698 bases
Orientation:
Minus strand

Genomic View for TPTE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPTE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPTE2 Gene

Proteins for TPTE2 Gene

  • Protein details for TPTE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XPS3-TPTE2_HUMAN
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2
    Protein Accession:
    Q6XPS3
    Secondary Accessions:
    • A1A4X0
    • A1A4X1
    • A8MX64
    • B1AQ16
    • B4DWZ2
    • Q5VUH2
    • Q8WWL4
    • Q8WWL5

    Protein attributes for TPTE2 Gene

    Size:
    522 amino acids
    Molecular mass:
    61112 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPTE2 Gene

neXtProt entry for TPTE2 Gene

Proteomics data for TPTE2 Gene at MOPED

Post-translational modifications for TPTE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPTE2 Gene

No data available for DME Specific Peptides for TPTE2 Gene

Domains for TPTE2 Gene

Gene Families for TPTE2 Gene

HGNC:
  • DUSPQ :Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

Suggested Antigen Peptide Sequences for TPTE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6XPS3

UniProtKB/Swiss-Prot:

TPTE2_HUMAN :
  • Q6XPS3
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with TPTE2: view

Function for TPTE2 Gene

Molecular function for TPTE2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate

Enzyme Numbers (IUBMB) for TPTE2 Gene

Gene Ontology (GO) - Molecular Function for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA --
genes like me logo Genes that share ontologies with TPTE2: view

Phenotypes for TPTE2 Gene

GenomeRNAi human phenotypes for TPTE2:
genes like me logo Genes that share phenotypes with TPTE2: view

Animal Model Products

CRISPR Products

miRNA for TPTE2 Gene

miRTarBase miRNAs that target TPTE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPTE2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TPTE2 Gene

Localization for TPTE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPTE2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform 4: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPTE2 Gene COMPARTMENTS Subcellular localization image for TPTE2 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 4
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPTE2: view

Pathways for TPTE2 Gene

genes like me logo Genes that share pathways with TPTE2: view

Pathways by source for TPTE2 Gene

Interacting Proteins for TPTE2 Gene

Gene Ontology (GO) - Biological Process for TPTE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006811 ion transport --
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with TPTE2: view

Compounds for TPTE2 Gene

(380) HMDB Compounds for TPTE2 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
Not Available
PI(16:0/16:0)
  • Phosphatidylinositol(32:0)
Not Available
PI(16:0/16:1(9Z))
  • Phosphatidylinositol(32:1)
Not Available
PI(16:0/16:2(9Z,12Z))
  • Phosphatidylinositol(16:0/16:2n4)
Not Available
genes like me logo Genes that share compounds with TPTE2: view

Transcripts for TPTE2 Gene

Unigene Clusters for TPTE2 Gene

Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPTE2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPTE2 Gene

No ASD Table

Relevant External Links for TPTE2 Gene

GeneLoc Exon Structure for
TPTE2
ECgene alternative splicing isoforms for
TPTE2

Expression for TPTE2 Gene

mRNA expression in normal human tissues for TPTE2 Gene

mRNA differential expression in normal tissues according to GTEx for TPTE2 Gene

This gene is overexpressed in Testis (24.0).

SOURCE GeneReport for Unigene cluster for TPTE2 Gene Hs.377488

mRNA Expression by UniProt/SwissProt for TPTE2 Gene

Q6XPS3-TPTE2_HUMAN
Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
genes like me logo Genes that share expressions with TPTE2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for TPTE2 Gene

Orthologs for TPTE2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPTE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC516736 35
  • 76.29 (n)
  • 63.92 (a)
-- 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC606856 35
  • 79.36 (n)
  • 67.5 (a)
-- 36
  • 48 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tpte 35
  • 75.33 (n)
  • 67.42 (a)
Tpte 16
Tpte 36
  • 50 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TPTE2 35
  • 99.17 (n)
  • 98.08 (a)
TPTE2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpte2 35
  • 73.97 (n)
  • 66.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves TPTE2 35
  • 64.37 (n)
  • 59.48 (a)
-- 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tpte2 35
  • 62.51 (n)
  • 56.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10039 35
zebrafish
(Danio rerio)
Actinopterygii tpte 35
  • 60.29 (n)
  • 55.65 (a)
tpte 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dnj-25 36
  • 7 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PTEN1 35
  • 55.43 (n)
  • 45.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for TPTE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPTE2 Gene

ENSEMBL:
Gene Tree for TPTE2 (if available)
TreeFam:
Gene Tree for TPTE2 (if available)

Paralogs for TPTE2 Gene

Paralogs for TPTE2 Gene

Selected SIMAP similar genes for TPTE2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPTE2: view

Variants for TPTE2 Gene

Sequence variations from dbSNP and Humsavar for TPTE2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs186043 -- 19,563,142(-) gccca(C/G)gctgg upstream-variant-2KB
rs192657 -- 19,550,781(+) CTTTC(C/T)TCCtt intron-variant
rs210541 -- 19,550,656(-) cactt(C/T)cttca intron-variant
rs369813 -- 19,533,935(-) CAGAT(C/T)TGAAA intron-variant
rs371321 -- 19,530,542(+) GTGCT(C/T)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPTE2 Gene

Variant ID Type Subtype PubMed ID
esv2747051 CNV Deletion 23290073
dgv334e199 CNV Deletion 23128226
nsv899851 CNV Gain 21882294
nsv469566 CNV Complex 16826518
nsv428286 CNV Loss 18775914
nsv523881 CNV Gain 19592680
dgv1550n71 CNV Gain 21882294
nsv469567 CNV Complex 16826518
esv26631 CNV Loss 19812545
esv2677314 CNV Deletion 23128226
esv2747058 CNV Deletion 23290073
nsv471122 CNV Loss 18288195
nsv523915 CNV Loss 19592680
nsv899854 CNV Gain 21882294
nsv899855 CNV Gain 21882294
nsv950 CNV Insertion 18451855
nsv523550 CNV Gain 19592680
nsv516945 CNV Gain+Loss 19592680

Relevant External Links for TPTE2 Gene

HapMap Linkage Disequilibrium report
TPTE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPTE2 Gene

Disorders for TPTE2 Gene

Relevant External Links for TPTE2

Genetic Association Database (GAD)
TPTE2
Human Genome Epidemiology (HuGE) Navigator
TPTE2

No disorders were found for TPTE2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TPTE2 Gene

Publications for TPTE2 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4
  2. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PMID: 14659893) Tapparel C. … Antonarakis S.E. (Gene 2003) 3 4 23
  3. TPIP: a novel phosphoinositide 3-phosphatase. (PMID: 11716755) Walker S.M. … Leslie N.R. (Biochem. J. 2001) 2 3 4
  4. The role of PTEN in the progression and survival of prostate cancer. (PMID: 12717346) Deocampo N.D. … Tindall D.J. (Minerva Endocrinol. 2003) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TPTE2 Gene

Sources for TPTE2 Gene

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