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GIFtS

TPTE2 Gene

protein-coding   GIFtS: 47
GCID: GC13M019997

Transmembrane Phosphoinositide 3-Phosphatase And Tensin...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 21 2     Phosphatidylinositol-3,4,5-Trisphosphate 3-Phosphatase TPTE22
Lipid Phosphatase TPIP2 3     PTEN-Like Inositol Lipid Phosphatase2
TPIP2 3     TPIP Lipid Phosphatase2
TPTE And PTEN Homologous Inositol Lipid Phosphatase2 3     EC 3.1.3.673
Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase TPTE22     

External Ids:    HGNC: 172991   Entrez Gene: 934922   Ensembl: ENSG000001329587   OMIM: 6067915   UniProtKB: Q6XPS33   

Export aliases for TPTE2 gene to outside databases

Previous GC identifers: GC13M017796 GC13M018895 GC13M000801


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPTE2 Gene:
TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the
3-position phosphate of inositol phospholipids.(supplied by OMIM, Jul 2002)

GeneCards Summary for TPTE2 Gene: 
TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2) is a protein-coding gene. Diseases associated with TPTE2 include prostate cancer, and prostatitis, and among its related super-pathways are Metabolic pathways and Synthesis of PIPs at the plasma membrane. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTEN.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPTE2 gene promoter:
         SRY   NF-kappaB2   RelA   NF-kappaB   NF-kappaB1   LyF-1   C/EBPalpha   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPTE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPTE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPTE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q12.11   Ensembl cytogenetic band:  13q12.11   HGNC cytogenetic band: 13q12.11

TPTE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPTE2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M019997:  view genomic region     (about GC identifiers)

Start:
19,997,017 bp from pter      End:
20,110,903 bp from pter
Size:
113,887 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2  
Size: 522 amino acids; 61112 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Subcellular location: Isoform 4: Cytoplasm
Secondary accessions: A1A4X0 A1A4X1 A8MX64 B1AQ16 Q5VUH2 Q8WWL4 Q8WWL5
Alternative splicing: 6 isoforms:  Q6XPS3-1   Q6XPS3-2   Q6XPS3-3   Q6XPS3-4   Q6XPS3-5   Q6XPS3-6   (Expressed in testis, strongly inhibits cell growth in HeLa cells)

Explore the universe of human proteins at neXtProt for TPTE2: NX_Q6XPS3

Explore proteomics data for TPTE2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6XPS3

  • TPTE2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPTE2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001135440.1  NP_001258779.1  NP_570141.3  NP_954863.2  

    ENSEMBL proteins: 
     ENSP00000372438   ENSP00000432402   ENSP00000375098   ENSP00000382974   ENSP00000383089  
     ENSP00000255310   ENSP00000372437   ENSP00000372435   ENSP00000442218  
    Reactome Protein details: Q6XPS3
    Human Recombinant Protein Products for TPTE2: 
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    Cloud-Clone Corp. Proteins for TPTE2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TPTE2 for ontologies           About GeneDecksing



    TPTE2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TPTE2 

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    Cloud-Clone Corp. CLIAs for TPTE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    5/6 InterPro protein domains (see all 6):
     IPR014019 Phosphatase_tensin-typ
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR016130 Tyr_Pase_AS
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry Q6XPS3

    ProtoNet protein and cluster: Q6XPS3

    UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain


    TPTE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPTE2_HUMAN, Q6XPS3
    Catalytic activity: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate +
    phosphate

         Enzyme Number (IUBMB): EC 3.1.3.671

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005216ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016314phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA--
         
    TPTE2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TPTE2:
     Increased HPV18 LCR reporter a  Increased apoptosis 

         1 MGI phenotypic allele for Tpte (no phenotypes)

    TPTE2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tptetm1Lex for TPTE2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TPTE2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TPTE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPTE2 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTPTE2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TPTE2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    2PI Metabolism
    PI Metabolism0.66
    3Glycerophospholipid biosynthesis
    Phospholipid metabolism0.64
    4Synthesis of PIPs at the early endosome membrane
    Synthesis of PIPs at the Golgi membrane0.36
    5D-myo-inositol (1,3,4)-trisphosphate biosynthesis
    3-phosphoinositide degradation0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TPTE2
        3-phosphoinositide degradation

    5        Reactome Pathways for TPTE2
        Metabolism
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism
    Synthesis of PIPs at the Golgi membrane



    TPTE2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPTE2

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation ----
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006811ion transport ----
    GO:0016311dephosphorylation ----

    TPTE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPTE2

    10/380 HMDB Compounds for TPTE2 (see all 380)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PI(16:0/16:0)Phosphatidylinositol(32:0) (see all 8)----
    PI(16:0/16:1(9Z))Phosphatidylinositol(32:1) (see all 14)----
    PI(16:0/16:2(9Z,12Z))Phosphatidylinositol(16:0/16:2n4) (see all 18)----
    PI(16:0/18:0)Phosphatidylinositol(16:0/18:0) (see all 8)----
    PI(16:0/18:1(11Z))Phosphatidylinositol(16:0/18:1w7) (see all 14)----
    PI(16:0/18:1(9Z))Phosphatidylinositol(16:0/18:1) (see all 14)----
    PI(16:0/18:2(9Z,12Z))PIno(16:0/18:2) (see all 14)----
    PI(16:0/20:0)PI(16:0/20:0) (see all 8)----
    PI(16:0/20:2(11Z,14Z))Phosphatidylinositol(16:0/20:2n6) (see all 14)----
    PI(16:0/20:3(5Z,8Z,11Z))Phosphatidylinositol(36:3) (see all 14)----

    Search CenterWatch for drugs/clinical trials and news about TPTE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPTE2 gene (5 alternative transcripts): 
    NM_199255.1  NM_001141968.1  NM_001271850.1  NM_130785.3  NM_199254.2  

    Unigene Cluster for TPTE2:

    Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
    Hs.377488  [show with all ESTs]
    Unigene Representative Sequence: NR_073485
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382978(uc010tcl.2 uc009zzk.3 uc001ume.3 uc009zzm.3)
    ENST00000462409 ENST00000390680 ENST00000400103(uc009zzl.3) ENST00000400230(uc001umd.3 uc010tcm.2)
    ENST00000255310 ENST00000382977 ENST00000382975 ENST00000457266
    miRNA
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    OriGene ORF clones in mouse, rat for TPTE2
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    GenScript: all cDNA clones in your preferred vector (see all 3): TPTE2 (NM_199254)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPTE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE2
    Sirion Biotech Customized lentivirus for stable overexpression of TPTE2 
                         Customized lentivirus expression plasmids for stable overexpression of TPTE2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPTE2

    Additional mRNA sequence: 

    AJ421032.1 AJ421033.1 AK301741.1 AY219890.1 BC128146.1 BC128147.1 FJ969729.1 NR_073485.1 
    NR_073486.1 NR_073487.1 

    2 DOTS entries:

    DT.101981716  DT.40106613 

    16 AceView cDNA sequences:

    BI061602 BI063797 AL079581 AJ421033 BG207812 AL079582 NM_199254 NM_130785 
    AY219890 NM_199255 AJ421032 AW393549 BG200515 BG206253 BG187093 BF092239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPTE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCTAAGT
    TPTE2 Expression
    About this image


    See TPTE2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.377488

    UniProtKB/Swiss-Prot: TPTE2_HUMAN, Q6XPS3
    Tissue specificity: Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be
    testis-specific

        SABiosciences Custom PCR Arrays for TPTE2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPTE2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpte1 , 5 transmembrane phosphatase with tensin homology1, 5 75.33(n)1
    67.42(a)1
      8 (11.20 cM)5
    2341291  NM_199257.21  NP_954866.21 
     222834415 
    chicken
    (Gallus gallus)
    Aves TPTE21 transmembrane phosphoinositide 3-phosphatase and tensin more 64.37(n)
    59.48(a)
      418885  XM_417079.2  XP_417079.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    60(a)
    53(a)
    many ↔ many
    many ↔ many
    GL343260.1(1399329-1400123)
    1(132594652-132629594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100392 Xenopus laevis transcribed sequence with weak similarity more 76.42(n)    BQ727249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tpte1 transmembrane phosphatase with tensin homology 59.8(n)
    54.56(a)
      327292  NM_001025458.1  NP_001020629.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-836
    Putative protein phosphatase tag-83
    17(a)
    possible ortholog
    I(5600669-5603481)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTEN11 Calcium/lipid-binding (CaLB) phosphatase 55.43(n)
    45.71(a)
      833936  NM_123302.3  NP_198756.2 


    ENSEMBL Gene Tree for TPTE2 (if available)
    TreeFam Gene Tree for TPTE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPTE2 gene
    PTEN2  DNAJC62  TNS12  TPTE2  TNS42  TNS32  TENC12  GAK2  
    6 SIMAP similar genes for TPTE2 using alignment to 2 protein entries:     TPTE2_HUMAN (see all proteins):
    TPTE2P1    TPTE    DKFZp434F1622    PTEN2    PTEN    PTENP1

    TPTE2 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for TPTE2 (see all 9)
    PGOHUM00000248336 PGOHUM00000248375 PGOHUM00000249945 PGOHUM00000248535 PGOHUM00000248538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2866 SNPs in TPTE2 are shown (see all 2866)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445442411,2
    C--995903(+) ATCTC-/TT/   
       TTTTT
    TTTTT
    6 -- int11NA 2
    rs1508255891,2
    C--19996532(+) TACTT-/ATCTTCAT 7 -- int10--------
    rs1495210811,2
    C--19996533(+) CTTAT-/CCTTCA 7 -- int10--------
    rs1491494581,2
    --19996624(+) TGCTCA/GGAATG 7 -- int10--------
    rs79856211,2
    C--19996763(+) TAAATC/TAGCTT 7 -- int10--------
    rs93194211,2
    C,F,A--19996831(+) AAATAC/TGTAAG 7 -- int13Minor allele frequency- T:0.50NA 6
    rs1900920411,2
    --19996873(+) ATATCC/TCAAGT 7 -- int10--------
    rs24972001,2
    C,H--19996885(+) TTTGCT/CATGAA 7 -- int15Minor allele frequency- C:0.00NA CSA 9
    rs357921501,2
    C--19996973(+) GGAAA-/GTGTGTG 7 -- int12Minor allele frequency- GT:0.00CSA 4
    rs1386737471,2
    C--19997098(+) GACTTA/TGGACA 7 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TPTE2 (19997017 - 20110903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for TPTE2 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747058CNV Deletion23290073
    dgv334e199CNV Deletion23128226
    esv2677314CNV Deletion23128226
    esv2747051CNV Deletion23290073
    nsv950CNV Insertion18451855
    nsv523915CNV Loss19592680
    nsv471122CNV Loss18288195
    nsv428286CNV Loss18775914
    esv26631CNV Loss19812545
    nsv523550CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606791    OMIM disorders: --

    2 diseases for TPTE2:    About MalaCards
    prostate cancer    prostatitis


    TPTE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPTE2
    Human Genome Epidemiology (HuGE) Navigator: TPTE2 (2 documents)

    Export disorders for TPTE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPTE2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with TPTE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
    2. TPIP: a novel phosphoinositide 3-phosphatase. (PubMed id 11716755)1, 2, 3 Walker S.M.... Leslie N.R. (2001)
    3. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PubMed id 14659893)1, 2, 9 Tapparel C.... Antonarakis S.E. (2003)
    4. A Novel Human TPIP Splice-Variant (TPIP-C2) mRNA, Expressed in Human and Mouse Tissues, Strongly Inhibits Cell Growth in HeLa Cells. (PubMed id 22164291)1, 2 Mishra R.R.... Rath P.C. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. The role of PTEN in the progression and survival of prostate cancer. (PubMed id 12717346)1, 3 Deocampo N.D....Tindall D.J. (2003)
    7. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (2013)
    8. A human phospholipid phosphatase activated by a transm embrane control module. (PubMed id 22896666)1 Halaszovich C.R....Oliver D. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Cell cycle arrest and apoptosis by expression of a nov el TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells. (PubMed id 22311048)1 Mishra R.R....Rath P.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93492 HGNC: 17299 AceView: TPTE2 Ensembl:ENSG00000132958 euGenes: HUgn93492
    ECgene: TPTE2 H-InvDB: TPTE2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPTE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPTE2 gene:
    Search GeneIP for patents involving TPTE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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