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Aliases for TPTE Gene

Aliases for TPTE Gene

  • Transmembrane Phosphatase With Tensin Homology 2 3 4 5
  • Cancer/Testis Antigen 44 2 3 4
  • PTEN-Related Tyrosine Phosphatase 2 3
  • Tumor Antigen BJ-HCC-5 3 4
  • CT44 3 4
  • Tensin, Putative Protein-Tyrosine Phosphatase 3
  • EC 4
  • PTEN2 3

External Ids for TPTE Gene

Previous GeneCards Identifiers for TPTE Gene

  • GC21M007669
  • GC21M009928
  • GC21M009929
  • GC21M010906

Summaries for TPTE Gene

Entrez Gene Summary for TPTE Gene

  • This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for TPTE Gene

TPTE (Transmembrane Phosphatase With Tensin Homology) is a Protein Coding gene. Diseases associated with TPTE include Acrocallosal Syndrome. Among its related pathways are Metabolism and PI Metabolism. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is TNS1.

UniProtKB/Swiss-Prot for TPTE Gene

  • Could be involved in signal transduction.

Gene Wiki entry for TPTE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPTE Gene

Genomics for TPTE Gene

Regulatory Elements for TPTE Gene

Promoters for TPTE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPTE on UCSC Golden Path with GeneCards custom track

Genomic Location for TPTE Gene

10,521,514 bp from pter
10,606,270 bp from pter
84,757 bases
Plus strand

Genomic View for TPTE Gene

Genes around TPTE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPTE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPTE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPTE Gene

Proteins for TPTE Gene

  • Protein details for TPTE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tyrosine-protein phosphatase TPTE
    Protein Accession:
    Secondary Accessions:
    • B2RAP7
    • C9J6D6
    • C9JKK8
    • Q6XPS4
    • Q6XPS5
    • Q71JA8
    • Q8NCS8

    Protein attributes for TPTE Gene

    551 amino acids
    Molecular mass:
    64322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPTE Gene


neXtProt entry for TPTE Gene

Proteomics data for TPTE Gene at MOPED

Post-translational modifications for TPTE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPTE Gene

No data available for DME Specific Peptides for TPTE Gene

Domains & Families for TPTE Gene

Suggested Antigen Peptide Sequences for TPTE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 tensin-type domain.
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with TPTE: view

Function for TPTE Gene

Molecular function for TPTE Gene

GENATLAS Biochemistry:
transmembrane phosphatase with tensin homology,putatively involved in linking the cell membrane to cytoskeleton,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Could be involved in signal transduction.

Enzyme Numbers (IUBMB) for TPTE Gene

Gene Ontology (GO) - Molecular Function for TPTE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TPTE: view
genes like me logo Genes that share phenotypes with TPTE: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TPTE

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPTE Gene

Localization for TPTE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPTE Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TPTE Gene COMPARTMENTS Subcellular localization image for TPTE gene
Compartment Confidence
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TPTE Gene

Pathways & Interactions for TPTE Gene

genes like me logo Genes that share pathways with TPTE: view

Interacting Proteins for TPTE Gene

Gene Ontology (GO) - Biological Process for TPTE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 10598804
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 10598804
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with TPTE: view

No data available for SIGNOR curated interactions for TPTE Gene

Drugs & Compounds for TPTE Gene

(1) Drugs for TPTE Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TPTE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with TPTE: view

Transcripts for TPTE Gene

Unigene Clusters for TPTE Gene

Transmembrane phosphatase with tensin homology:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPTE Gene

No ASD Table

Relevant External Links for TPTE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPTE Gene

mRNA expression in normal human tissues for TPTE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPTE Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for TPTE Gene

This gene is overexpressed in Bone (53.5) and Testis (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPTE Gene

SOURCE GeneReport for Unigene cluster for TPTE Gene Hs.122986

mRNA Expression by UniProt/SwissProt for TPTE Gene

Tissue specificity: Exclusively expressed in testis.
genes like me logo Genes that share expression patterns with TPTE: view

Protein tissue co-expression partners for TPTE Gene

- Elite partner

Primer Products

Orthologs for TPTE Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPTE Gene

Organism Taxonomy Gene Similarity Type Details
(Danio rerio)
Actinopterygii wufi24b06 35
Species with no ortholog for TPTE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPTE Gene

Gene Tree for TPTE (if available)
Gene Tree for TPTE (if available)

Paralogs for TPTE Gene

Paralogs for TPTE Gene

(4) SIMAP similar genes for TPTE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPTE: view

Variants for TPTE Gene

Sequence variations from dbSNP and Humsavar for TPTE Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs150482 - 10,602,110(+) CGGTC(C/T)ACCTC reference, missense
VAR_036516 A breast cancer sample
rs1810856 - 10,569,454(-) GAAGT(A/C/T)GAAGT reference, missense
rs169758 - 10,605,542(+) AGCTG(A/G)ATCCG reference, missense
rs9996 - 10,602,146(-) CCGAA(C/G/T)AGAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TPTE Gene

Variant ID Type Subtype PubMed ID
esv28756 CNV Gain+Loss 19812545
nsv913329 CNV Gain 21882294
nsv442783 CNV CNV 18776908
dgv69n68 CNV Loss 17160897
nsv428382 CNV Gain+Loss 18775914
nsv913337 CNV Gain 21882294
nsv9837 CNV Gain+Loss 18304495
dgv711n67 CNV Gain 20364138
dgv712n67 CNV Gain 20364138
nsv819313 CNV Gain 19587683
esv32564 CNV Gain+Loss 17666407
esv29976 CNV Gain 17803354
nsv834040 CNV Loss 17160897
nsv437841 CNV Loss 16327808
dgv67n17 CNV Loss 16327808
esv2657054 CNV Deletion 23128226
dgv1348e1 CNV Complex 17122850
dgv1349e1 CNV Complex 17122850
esv720 CNV CNV 17122850
esv1000174 CNV Deletion 20482838
nsv436336 CNV Deletion 17901297
nsv512628 CNV Loss 21212237
esv2661615 CNV Deletion 23128226
nsv438312 CNV Loss 16468122
esv269554 CNV Insertion 20981092
esv2668163 CNV Deletion 23128226
esv992725 CNV Deletion 20482838
esv991443 OTHER Inversion 20482838

Variation tolerance for TPTE Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPTE Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPTE Gene

Disorders for TPTE Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPTE Gene - From: DISEASES

Disorder Aliases PubMed IDs
acrocallosal syndrome
  • joubert syndrome 12
- elite association - COSMIC cancer census association via MalaCards
Search TPTE in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPTE

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPTE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPTE Gene

Publications for TPTE Gene

  1. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PMID: 14659893) Tapparel C. … Antonarakis S.E. (Gene 2003) 2 3 4 23 67
  2. The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. (PMID: 11810268) Guipponi M. … Antonarakis S.E. (Hum. Genet. 2001) 2 3
  3. A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. (PMID: 10598804) Chen H. … Antonarakis S.E. (Hum. Genet. 1999) 3 23
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PMID: 23936387) A9stensson M. … Torinsson-Naluai A.8. (PLoS ONE 2013) 3

Products for TPTE Gene

Sources for TPTE Gene