Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TPTE Gene

protein-coding   GIFtS: 56
GCID: GC21M010906

Transmembrane Phosphatase With Tensin Homology

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

TryGeneCards Plus

Aliases
Transmembrane Phosphatase With Tensin Homology1 2 3     Tensin, Putative Protein-Tyrosine Phosphatase, EC 3.1.3.4811
Cancer/Testis Antigen 441 2 3     PTEN22
PTEN-Related Tyrosine Phosphatase1 2     Putative Tyrosine-Protein Phosphatase TPTE2
Tumor Antigen BJ-HCC-52 3     Tensin, Putative Protein-Tyrosine Phosphatase2
CT442 3     EC 3.1.3.483

External Ids:    HGNC: 120231   Entrez Gene: 71792   Ensembl: ENSG000001661577   OMIM: 6043365   UniProtKB: P561803   

Export aliases for TPTE gene to outside databases

Previous GC identifers: GC21M007669 GC21M009928 GC21M009929


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TPTE Gene:
This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of
the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for TPTE Gene:
TPTE (transmembrane phosphatase with tensin homology) is a protein-coding gene. Diseases associated with TPTE include down syndrome, and breast and colorectal cancer. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is DNAJC6.

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
Function: Could be involved in signal transduction

Gene Wiki entry for TPTE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_029490.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPTE gene promoter:
         AhR   p53   MyoD   Pax-2   Pax-2a   Egr-4   Arnt   Egr-2   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPTE promoter sequence

   Search Chromatin IP Primers for TPTE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPTE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21p11   Ensembl cytogenetic band:  21p11.1   HGNC cytogenetic band: 21p11
Nature(405: 311-319) cytogenetic band:   21p11
TPTE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPTE gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M010906:   GeneLoc Nature:405,311-319
Start:
10,906,201 bp from pter       425 bp from start of p-sequenced region
End:
11,029,719 bp from pter 84,293 bp from start of p-sequenced region
Size:
123,519 bases 83,869 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF007118
genomic clones: B15L0C0 B7L1C4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180 (See protein sequence)
Recommended Name: Putative tyrosine-protein phosphatase TPTE  
Size: 551 amino acids; 64322 Da
Secondary accessions: B2RAP7 C9J6D6 C9JKK8 Q6XPS4 Q6XPS5 Q71JA8 Q8NCS8
Alternative splicing: 4 isoforms:  P56180-1   P56180-2   P56180-3   P56180-4   

Explore the universe of human proteins at neXtProt for TPTE: NX_P56180

Explore proteomics data for TPTE at MOPED


See TPTE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001277153.1  NP_954868.1  NP_954869.1  NP_954870.2  

ENSEMBL proteins: 
 ENSP00000298232   ENSP00000355208   ENSP00000344441   ENSP00000399471  
Reactome Protein details: P56180

TPTE Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for TPTE
OriGene Protein Over-expression Lysate for TPTE
OriGene MassSpec for TPTE
OriGene Custom Protein Services for TPTE
GenScript Custom Purified and Recombinant Proteins Services for TPTE
Novus Biologicals TPTE Protein
Novus Biologicals TPTE Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for TPTE

TPTE Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for TPTE
OriGene Custom Antibody Services for TPTE
Novus Biologicals TPTE Antibodies
Abcam antibodies for TPTE
Cloud-Clone Corp. Antibodies for TPTE
ThermoFisher Antibodies for TPTE
LSBio Antibodies in human, mouse, rat for TPTE

TPTE Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for TPTE
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TPTE
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TPTE
Cloud-Clone Corp. CLIAs for TPTE


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

Selected InterPro protein domains (see all 6):
 IPR014019 Phosphatase_tensin-typ
 IPR016130 Tyr_Pase_AS
 IPR000340 Dual-sp_phosphatase_cat-dom
 IPR005821 Ion_trans_dom
 IPR014020 Tensin_phosphatase_C2-dom

Graphical View of Domain Structure for InterPro Entry P56180

ProtoNet protein and cluster: P56180

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
Similarity: Contains 1 C2 tensin-type domain
Similarity: Contains 1 phosphatase tensin-type domain


TPTE for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TPTE_HUMAN, P56180
Function: Could be involved in signal transduction
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

     Genatlas biochemistry entry for TPTE:
transmembrane phosphatase with tensin homology,putatively involved in linking the cell membrane to
cytoskeleton,expressed in testis

     Enzyme Number (IUBMB): EC 3.1.3.481

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004725protein tyrosine phosphatase activity IEA--
GO:0005216ion channel activity IEA--
GO:0005515protein binding ----
GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
GO:0016791phosphatase activity ----
     
TPTE for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TPTE:
 Increased apoptosis 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPTE
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPTE

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPTE
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPTE

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat TPTE using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate TPTE
SwitchGear 3'UTR luciferase reporter plasmidTPTE 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TPTE
Predesigned siRNA for gene silencing in human, mouse, rat TPTE

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TPTE

Clone
Products:
     
OriGene clones in human, mouse for TPTE (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): TPTE (NM_199259)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPTE
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for TPTE
Browse ESI BIO Cell Lines and PureStem Progenitors for TPTE 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
TPTE_HUMAN, P56180: Membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
plasma membrane3
endoplasmic reticulum1
mitochondrion1
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

TPTE for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for TPTE About                                                                                                See pathways by source

SuperPathContained pathways About
1PI Metabolism
PI Metabolism0.65
Synthesis of PIPs at the Golgi membrane0.00
2Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
3Glycerophospholipid biosynthesis
Phospholipid metabolism0.64

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for TPTE
    Synthesis of PIPs at the Golgi membrane



TPTE for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Array including TPTE: 
          Protein Phosphatases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TPTE

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

Selected Interacting proteins for TPTE (ENSP000003552084) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
MTORENSP000003545584STRING: ENSP00000354558
AFF4ENSP000002653434STRING: ENSP00000265343
TSC1ENSP000002985524STRING: ENSP00000298552
IRS1ENSP000003048954STRING: ENSP00000304895
IRS2ENSP000003650164STRING: ENSP00000365016
About this table

Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006470protein dephosphorylation TAS10598804
GO:0006811ion transport ----
GO:0007165signal transduction TAS10598804
GO:0016311dephosphorylation ----
GO:0035335peptidyl-tyrosine dephosphorylation TAS10598804

TPTE for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TPTE

2 HMDB Compounds for TPTE    About this table
CompoundSynonyms CAS #PubMed Ids
PhosphateNFB Orthophosphate (see all 13)14265-44-2--
WaterDihydrogen oxide (see all 2)7732-18-5--

1 Novoseek inferred chemical compound relationship for TPTE gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 25.1 2 14659893 (1), 10598804 (1)



TPTE for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for TPTE gene (4 alternative transcripts): 
NM_001290224.1  NM_199259.3  NM_199260.3  NM_199261.3  

Unigene Cluster for TPTE:

Transmembrane phosphatase with tensin homology
Hs.122986  [show with all ESTs]
Unigene Representative Sequence: AL833345
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000298232(uc002yiq.1 uc002yir.1 uc010gkv.1) ENST00000361285(uc002yip.1)
ENST00000342420 ENST00000447568 ENST00000415664(uc002yis.1) ENST00000328758

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TPTE using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate TPTE
SwitchGear 3'UTR luciferase reporter plasmidTPTE 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TPTE
Predesigned siRNA for gene silencing in human, mouse, rat TPTE
Clone
Products:
     
OriGene clones in human, mouse for TPTE (see all 14)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): TPTE (NM_199259)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPTE
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TPTE
OriGene qSTAR qPCR primer pairs in human, mouse for TPTE
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPTE
  QuantiTect SYBR Green Assays in human, mouse, rat TPTE
  QuantiFast Probe-based Assays in human, mouse, rat TPTE

Additional mRNA sequence: 

AF007118.1 AF495908.1 AK308254.1 AK314285.1 AL833345.1 AY219886.1 AY219887.1 AY219888.1 
BC028719.1 

6 DOTS entries:

DT.95353703  DT.101981110  DT.101979855  DT.411245  DT.91658794  DT.100644810 

Selected AceView cDNA sequences (see all 73):

AW079913 AA770191 AI200912 AI220478 AI023215 AA889707 AI149736 AA971065 
BX097791 AY219886 NM_199260 BV191255 AY219887 AA812627 BG724427 AI393568 
AL833345 AL137389 AA608862 NM_013315 CD624728 AA758564 BI561491 AI026909 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TPTE    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP1:                                                                                                                                                      
SP2:                                      -                                                                                                               
SP3:                                      -     -                                                                                                         
SP4:                    -     -     -     -     -                                                                                                         


ECgene alternative splicing isoforms for TPTE

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

TPTE expression in normal human tissues (normalized intensities)      TPTE embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGGTTGGGG
TPTE Expression
About this image


TPTE expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         XY Germ Cells Testis Cord
         Testis Interstitium
 
 Gonad
         XY Germ Cells Testis Cord
TPTE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TPTE Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.122986

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
Tissue specificity: Exclusively expressed in testis

    Pathway & Disease-focused RT2 Profiler PCR Array including TPTE: 
          Protein Phosphatases in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for TPTE
OriGene qSTAR qPCR primer pairs in human, mouse for TPTE
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPTE
QuantiTect SYBR Green Assays in human, mouse, rat TPTE
QuantiFast Probe-based Assays in human, mouse, rat TPTE
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for TPTE gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
51(a)
1 → many
1(169788267-169803952)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
59(a)
51(a)
many ↔ many
many ↔ many
GL343260.1(1399329-1400123)
1(132594652-132629594)
zebrafish
(Danio rerio)
Actinopterygii wufi24b062 wufi24b06 74(n)   333972  AW153648.1 
worm
(Caenorhabditis elegans)
Secernentea dnj-256
Protein DNJ-25, isoform a (dnj-25) mRNA, complete ...
6(a)
many ↔ many
V(20729948-20744339) WBGene00001043
        Species with no ortholog for TPTE

ENSEMBL Gene Tree for TPTE (if available)
TreeFam Gene Tree for TPTE (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for TPTE gene
DNAJC62  PTEN2  TNS12  TENC12  GAK2  TPTE22  TNS42  TNS32  
4 SIMAP similar genes for TPTE using alignment to 2 protein entries:     TPTE_HUMAN (see all proteins):
TPTE2    PTEN2    PTENP1    PTEN

TPTE for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for TPTE
PGOHUM00000250333 PGOHUM00000249997


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for TPTE (see all 2115)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0365164
A breast cancer sample4--see VAR_0365162 R Q mis40--------
rs589350541,2
C--10906258(+) TACTTATC/-TTCAT 6 -- int1 cds11Minor allele frequency- -:0.50CSA 2
rs1131654751,2
C--10906258(+) TACTTA/C/TTCTTC 3 -- int10--------
rs286167461,2
C,F--10906293(+) CAACCC/G/TCCATG 3 -- int1 ese33NA WA 8
rs29400491,2
C,F--10906360(-) CACTCT/CCTTTC 3 -- int1 ese33Minor allele frequency- C:0.45NA CSA 11
rs29861051,2
F--10906361(+) AAAGGG/CAGTGT 3 -- int1 ese33Minor allele frequency- C:0.25NA 12
rs1835191781,2
--10906524(+) GTGAAC/TCAAAG 3 -- int10--------
rs1865750791,2
--10906703(+) ACTGTA/GAAGTA 3 -- int10--------
rs1697571,2
C,F,H--10906723(+) AAAAAA/CGAAGA 3 -- int1 trp311Minor allele frequency- C:0.11NS EA NA CSA 400
rs38328921,2
C--10906736(+) ACACT-/AGACAT 3 -- int11Minor allele frequency- A:0.50CSA 2

HapMap Linkage Disequilibrium report for TPTE (10906201 - 11029719 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TPTE (see all 28):    About this table    
Variant IDTypeSubtypePubMed ID
esv992725CNV Deletion20482838
esv2668163CNV Deletion23128226
esv2661615CNV Deletion23128226
esv1000174CNV Deletion20482838
esv2657054CNV Deletion23128226
nsv436336CNV Deletion17901297
esv269554CNV Insertion20981092
nsv438312CNV Loss16468122
nsv437841CNV Loss16327808
dgv67n17CNV Loss16327808

Human Gene Mutation Database (HGMD): TPTE
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TPTE
DNA2.0 Custom Variant and Variant Library Synthesis for TPTE

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 604336    OMIM disorders: --

4 diseases for TPTE:    About MalaCards
down syndrome    breast and colorectal cancer    hepatocellular carcinoma    colorectal cancer


TPTE for disorders           About GeneDecksing

Genetic Association Database (GAD): TPTE
Human Genome Epidemiology (HuGE) Navigator: TPTE (1 document)

Export disorders for TPTE gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for TPTE gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with TPTE)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PubMed id 14659893)1, 2, 3, 9 Tapparel C.... Antonarakis S.E. (Gene 2003)
  2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M.... Yaspo M.-L. (Nature 2000)
  3. A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. (PubMed id 10598804)1, 2, 9 Chen H....Antonarakis S.E. (Hum. Genet. 1999)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
  6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
  9. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PubMed id 18854154)1 KAPnig R....Chanda S.K. (Cell 2008)
  10. Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome. (PubMed id 18074101)1 Shaw S.W....Hsieh F.J. (J. Hum. Genet. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 7179 HGNC: 12023 AceView: TPTE Ensembl:ENSG00000166157 euGenes: HUgn7179
ECgene: TPTE H-InvDB: TPTE

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for TPTE Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for TPTE gene:
Search GeneIP for patents involving TPTE

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for TPTE   OriGene RNAi products in human, mouse, rat for TPTE  
 OriGene qPCR primer pairs and template standards for TPTE   OriGene Protein Over-expression Lysate for TPTE  
 OriGene MassSpec something-or-other for TPTE   OriGene clones in human, mouse for TPTE  
 OriGene qSTAR qPCR primer pairs in human, mouse for TPTE   OriGene Purified Protein for TPTE  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for TPTE   OriGene Custom Protein Services for TPTE  

 
 
 Block miRNA regulation of human, mouse, rat TPTE using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TPTE
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPTE Predesigned siRNA for gene silencing in human, mouse, rat TPTE
 QuantiFast Probe-based Assays in human, mouse, rat TPTE QuantiTect SYBR Green Assays in human, mouse, rat TPTE
 PCR Arrays including human, mouse, rat TPTE Search Chromatin IP Primers for TPTE
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPTE  Search GeneGlobe Interaction Network for TPTE
 Regulatory tfbs in TPTE promoter
 GenScript Custom Purified and Recombinant Proteins Services for TPTE GenScript cDNA clones with any tag delivered in your preferred vector for TPTE
 GenScript Custom Assay Services for TPTE GenScript Custom overexpressing Cell Line Services for TPTE
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for TPTE
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 TPTE antibodies
 TPTE proteins
 TPTE lysates
 Antibodies for TPTE
 See all of Abcam's Antibodies, Kits and Proteins for TPTE
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for TPTE
 Antibodies for TPTE
 ELISAs for TPTE
 CLIAs for TPTE



 Browse ESI BIO Cell Lines and PureStem Progenitors for TPTE
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE
 SwitchGear 3'UTR luciferase reporter plasmids for TPTE
 SwitchGear Promoter luciferase reporter plasmids for TPTE
 ThermoFisher Antibodies for TPTE
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPTE
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPTE
 LSBio Antibodies in human, mouse, rat for TPTE
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      TPTE gene at Home site.
Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4