Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPTE Gene

Aliases for TPTE Gene

  • Transmembrane Phosphatase With Tensin Homology 2 3 4
  • Cancer/Testis Antigen 44 2 3 4
  • PTEN-Related Tyrosine Phosphatase 2 3
  • Tumor Antigen BJ-HCC-5 3 4
  • CT44 3 4
  • Tensin, Putative Protein-Tyrosine Phosphatase 3
  • EC 3.1.3.48 4
  • PTEN2 3

External Ids for TPTE Gene

Previous GeneCards Identifiers for TPTE Gene

  • GC21M007669
  • GC21M009928
  • GC21M009929
  • GC21M010906

Summaries for TPTE Gene

Entrez Gene Summary for TPTE Gene

  • This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for TPTE Gene

TPTE (Transmembrane Phosphatase With Tensin Homology) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity.

UniProtKB/Swiss-Prot for TPTE Gene

  • Could be involved in signal transduction

Gene Wiki entry for TPTE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPTE Gene

Genomics for TPTE Gene

Regulatory Elements for TPTE Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPTE Gene

Chromosome:
21
Start:
10,521,514 bp from pter
End:
10,606,270 bp from pter
Size:
84,757 bases
Orientation:
Plus strand

Genomic View for TPTE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPTE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPTE Gene

Proteins for TPTE Gene

  • Protein details for TPTE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56180-TPTE_HUMAN
    Recommended name:
    Putative tyrosine-protein phosphatase TPTE
    Protein Accession:
    P56180
    Secondary Accessions:
    • B2RAP7
    • C9J6D6
    • C9JKK8
    • Q6XPS4
    • Q6XPS5
    • Q71JA8
    • Q8NCS8

    Protein attributes for TPTE Gene

    Size:
    551 amino acids
    Molecular mass:
    64322 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TPTE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPTE Gene

Proteomics data for TPTE Gene at MOPED

Post-translational modifications for TPTE Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPTE Gene

Antibody Products

No data available for DME Specific Peptides for TPTE Gene

Domains & Families for TPTE Gene

Suggested Antigen Peptide Sequences for TPTE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56180

UniProtKB/Swiss-Prot:

TPTE_HUMAN :
  • Contains 1 C2 tensin-type domain.
Domain:
  • Contains 1 C2 tensin-type domain.
  • Contains 1 phosphatase tensin-type domain.
genes like me logo Genes that share domains with TPTE: view

Function for TPTE Gene

Molecular function for TPTE Gene

GENATLAS Biochemistry:
transmembrane phosphatase with tensin homology,putatively involved in linking the cell membrane to cytoskeleton,expressed in testis
UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
UniProtKB/Swiss-Prot Function:
Could be involved in signal transduction

Enzyme Numbers (IUBMB) for TPTE Gene

Gene Ontology (GO) - Molecular Function for TPTE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005216 ion channel activity --
GO:0005515 protein binding --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with TPTE: view
genes like me logo Genes that share phenotypes with TPTE: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPTE

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TPTE Gene

Localization for TPTE Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPTE Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TPTE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPTE: view

No data available for Subcellular locations from COMPARTMENTS for TPTE Gene

Pathways & Interactions for TPTE Gene

genes like me logo Genes that share pathways with TPTE: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TPTE Gene

Gene Ontology (GO) - Biological Process for TPTE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation TAS 10598804
GO:0006811 ion transport --
GO:0007165 signal transduction TAS 10598804
GO:0016311 dephosphorylation --
GO:0035335 peptidyl-tyrosine dephosphorylation TAS 10598804
genes like me logo Genes that share ontologies with TPTE: view

No data available for SIGNOR curated interactions for TPTE Gene

Drugs & Compounds for TPTE Gene

(1) Drugs for TPTE Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
tyrosine Nutra 547

(3) Additional Compounds for TPTE Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with TPTE: view

Transcripts for TPTE Gene

Unigene Clusters for TPTE Gene

Transmembrane phosphatase with tensin homology:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPTE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPTE Gene

No ASD Table

Relevant External Links for TPTE Gene

GeneLoc Exon Structure for
TPTE
ECgene alternative splicing isoforms for
TPTE

Expression for TPTE Gene

mRNA expression in normal human tissues for TPTE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPTE Gene

This gene is overexpressed in Testis (x51.8).

Protein differential expression in normal tissues from HIPED for TPTE Gene

This gene is overexpressed in Bone (53.5) and Testis (15.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPTE Gene



SOURCE GeneReport for Unigene cluster for TPTE Gene Hs.122986

mRNA Expression by UniProt/SwissProt for TPTE Gene

P56180-TPTE_HUMAN
Tissue specificity: Exclusively expressed in testis.
genes like me logo Genes that share expression patterns with TPTE: view

Protein tissue co-expression partners for TPTE Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TPTE Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPTE Gene

Organism Taxonomy Gene Similarity Type Details
zebrafish
(Danio rerio)
Actinopterygii wufi24b06 35
Species with no ortholog for TPTE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TPTE Gene

ENSEMBL:
Gene Tree for TPTE (if available)
TreeFam:
Gene Tree for TPTE (if available)

Paralogs for TPTE Gene

(4) SIMAP similar genes for TPTE Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TPTE: view

No data available for Paralogs for TPTE Gene

Variants for TPTE Gene

Sequence variations from dbSNP and Humsavar for TPTE Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_025400 -
VAR_036516 A breast cancer sample
VAR_057347 -
VAR_057348 -
VAR_061895 -

Structural Variations from Database of Genomic Variants (DGV) for TPTE Gene

Variant ID Type Subtype PubMed ID
esv28756 CNV Gain+Loss 19812545
nsv913329 CNV Gain 21882294
nsv442783 CNV CNV 18776908
dgv69n68 CNV Loss 17160897
nsv428382 CNV Gain+Loss 18775914
nsv913337 CNV Gain 21882294
nsv9837 CNV Gain+Loss 18304495
dgv711n67 CNV Gain 20364138
dgv712n67 CNV Gain 20364138
nsv819313 CNV Gain 19587683
esv32564 CNV Gain+Loss 17666407
esv29976 CNV Gain 17803354
nsv834040 CNV Loss 17160897
nsv437841 CNV Loss 16327808
dgv67n17 CNV Loss 16327808
esv2657054 CNV Deletion 23128226
dgv1348e1 CNV Complex 17122850
dgv1349e1 CNV Complex 17122850
esv720 CNV CNV 17122850
esv1000174 CNV Deletion 20482838
nsv436336 CNV Deletion 17901297
nsv512628 CNV Loss 21212237
esv2661615 CNV Deletion 23128226
nsv438312 CNV Loss 16468122
esv269554 CNV Insertion 20981092
esv2668163 CNV Deletion 23128226
esv992725 CNV Deletion 20482838
esv991443 OTHER Inversion 20482838

Variation tolerance for TPTE Gene

Residual Variation Intolerance Score: 99.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPTE Gene

HapMap Linkage Disequilibrium report
TPTE
Human Gene Mutation Database (HGMD)
TPTE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPTE Gene

Disorders for TPTE Gene

Relevant External Links for TPTE

Genetic Association Database (GAD)
TPTE
Human Genome Epidemiology (HuGE) Navigator
TPTE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPTE
genes like me logo Genes that share disorders with TPTE: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPTE Gene

Publications for TPTE Gene

  1. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PMID: 14659893) Tapparel C. … Antonarakis S.E. (Gene 2003) 2 23 67
  2. PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. (PMID: 17240336) Leslie N.R. … Weijer C.J. (Curr. Biol. 2007) 23 67
  3. Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients. (PMID: 12865919) Dong X.Y. … Chen W.F. (Br. J. Cancer 2003) 23 67
  4. The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. (PMID: 11810268) Guipponi M. … Antonarakis S.E. (Hum. Genet. 2001) 2 67
  5. A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. (PMID: 10598804) Chen H. … Antonarakis S.E. (Hum. Genet. 1999) 23 67

Products for TPTE Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TPTE
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TPTE
    • Block miRNA regulation of TPTE using miScript Target Protectors

    Sources for TPTE Gene

    Back to Top

    Content