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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPTE Gene

protein-coding   GIFtS: 54
GCID: GC21M010906

Transmembrane Phosphatase With Tensin Homology

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Transmembrane Phosphatase With Tensin Homology1 2 3     Tensin, Putative Protein-Tyrosine Phosphatase, EC 3.1.3.4811
Cancer/Testis Antigen 441 2 3     PTEN22
PTEN-Related Tyrosine Phosphatase1 2     Putative Tyrosine-Protein Phosphatase TPTE2
Tumor Antigen BJ-HCC-52 3     Tensin, Putative Protein-Tyrosine Phosphatase2
CT442 3     EC 3.1.3.483

External Ids:    HGNC: 120231   Entrez Gene: 71792   Ensembl: ENSG000001661577   OMIM: 6043365   UniProtKB: P561803   

Export aliases for TPTE gene to outside databases

Previous GC identifers: GC21M007669 GC21M009928 GC21M009929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TPTE Gene: 
TPTE (transmembrane phosphatase with tensin homology) is a protein-coding gene. Diseases associated with TPTE include down syndrome, and hepatocellular carcinoma. GO annotations related to this gene include ion channel activity and protein tyrosine phosphatase activity. An important paralog of this gene is PTEN.

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
Function: Could be involved in signal transduction

Gene Wiki entry for TPTE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_029490.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPTE gene promoter:
         AhR   p53   MyoD   Pax-2   Pax-2a   Egr-4   Arnt   Egr-2   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPTE promoter sequence

   Search SABiosciences Chromatin IP Primers for TPTE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPTE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21p11   Ensembl cytogenetic band:  21p11.1   HGNC cytogenetic band: 21p11
Nature(405: 311-319) cytogenetic band:   21p11
TPTE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPTE gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M010906:   GeneLoc Nature:405,311-319
Start:
10,906,201 bp from pter       425 bp from start of p-sequenced region
End:
11,029,719 bp from pter 84,293 bp from start of p-sequenced region
Size:
123,519 bases 83,869 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF007118
genomic clones: B15L0C0 B7L1C4


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180 (See protein sequence)
Recommended Name: Putative tyrosine-protein phosphatase TPTE  
Size: 551 amino acids; 64322 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2RAP7 C9J6D6 C9JKK8 Q6XPS4 Q6XPS5 Q71JA8 Q8NCS8
Alternative splicing: 4 isoforms:  P56180-1   P56180-2   P56180-3   P56180-4   

Explore the universe of human proteins at neXtProt for TPTE: NX_P56180

Explore proteomics data for TPTE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56180

  • TPTE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TPTE Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_954868.1  NP_954869.1  NP_954870.2  

    ENSEMBL proteins: 
     ENSP00000298232   ENSP00000355208   ENSP00000344441   ENSP00000399471  

    Human Recombinant Protein Products for TPTE: 
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    OriGene Custom Protein Services for TPTE
    GenScript Custom Purified and Recombinant Proteins Services for TPTE
    Novus Biologicals TPTE Proteins
    Novus Biologicals TPTE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TPTE 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    TPTE for ontologies           About GeneDecksing



    TPTE Antibody Products: 
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    Cloud-Clone Corp. ELISAs for TPTE 
    Cloud-Clone Corp. CLIAs for TPTE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPQ: Protein tyrosine phosphatases / Class I Cys-based PTPs : PTENs

    5/6 InterPro protein domains (see all 6):
     IPR014019 Phosphatase_tensin-typ
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR016130 Tyr_Pase_AS
     IPR000340 Dual-sp_phosphatase_cat-dom
     IPR005821 Ion_trans_dom

    Graphical View of Domain Structure for InterPro Entry P56180

    ProtoNet protein and cluster: P56180

    UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phosphatase tensin-type domain


    TPTE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPTE_HUMAN, P56180
    Function: Could be involved in signal transduction
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Genatlas biochemistry entry for TPTE:
    transmembrane phosphatase with tensin homology,putatively involved in linking the cell membrane to
    cytoskeleton,expressed in testis

         Enzyme Number (IUBMB): EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005216ion channel activity IEA--
    GO:0005515protein binding ----
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IEA--
    GO:0016791phosphatase activity ----
         
    TPTE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TPTE:
     Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TPTE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TPTE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPTE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPTE 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPTE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TPTE
    SwitchGear 3'UTR luciferase reporter plasmidTPTE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of TPTE 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPTE

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TPTE (ENSP000003552084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947ENSP000003202954STRING: ENSP00000320295
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation TAS10598804
    GO:0006811ion transport ----
    GO:0007165signal transduction TAS10598804
    GO:0016311dephosphorylation ----
    GO:0035335peptidyl-tyrosine dephosphorylation TAS10598804

    TPTE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPTE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPTE

    2 HMDB Compounds for TPTE    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 Novoseek inferred chemical compound relationship for TPTE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 25.1 2 14659893 (1), 10598804 (1)

    Search CenterWatch for drugs/clinical trials and news about TPTE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TPTE gene (3 alternative transcripts): 
    NM_199259.2  NM_199260.2  NM_199261.2  

    Unigene Cluster for TPTE:

    Transmembrane phosphatase with tensin homology
    Hs.122986  [show with all ESTs]
    Unigene Representative Sequence: AL833345
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298232(uc002yiq.1 uc002yir.1 uc010gkv.1) ENST00000361285(uc002yip.1)
    ENST00000342420 ENST00000447568 ENST00000415664(uc002yis.1) ENST00000328758

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPTE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TPTE
    SwitchGear 3'UTR luciferase reporter plasmidTPTE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TPTE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPTE
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    OriGene clones in human, mouse for TPTE (see all 13)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TPTE (NM_199259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPTE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPTE
    Sirion Biotech Customized lentivirus for stable overexpression of TPTE 
                         Customized lentivirus expression plasmids for stable overexpression of TPTE 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TPTE
    OriGene qSTAR qPCR primer pairs in human, mouse for TPTE
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPTE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPTE

    Additional mRNA sequence: 

    AF007118.1 AF495908.1 AK308254.1 AK314285.1 AL833345.1 AY219886.1 AY219887.1 AY219888.1 
    BC028719.1 

    6 DOTS entries:

    DT.95353703  DT.101981110  DT.101979855  DT.411245  DT.91658794  DT.100644810 

    24/73 AceView cDNA sequences (see all 73):

    AI200912 AA770191 AI220478 AA889707 BX097791 AI023215 AA971065 AI149736 
    AW079913 AF007118 AA812627 BC028719 BU853741 BV191255 BF971139 CD243860 
    CD624728 AW085061 AI026909 BM083927 AY219886 AY219887 AA608862 AY219888 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TPTE    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:                                                                                                                                                      
    SP2:                                      -                                                                                                               
    SP3:                                      -     -                                                                                                         
    SP4:                    -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for TPTE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPTE expression in normal human tissues (normalized intensities)      TPTE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGTTGGGG
    TPTE Expression
    About this image


    TPTE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             XY Germ Cells Testis Cord
             Testis Interstitium
             sperm   
     
     Gonad
             XY Germ Cells Testis Cord

    See TPTE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPTE

    SOURCE GeneReport for Unigene cluster: Hs.122986

    UniProtKB/Swiss-Prot: TPTE_HUMAN, P56180
    Tissue specificity: Exclusively expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Array including TPTE: 
              Protein Phosphatases in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPTE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPTE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TPTE gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TPTE6
    Uncharacterized protein
    51(a)
    1 → many
    1(169788267-169803952)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    59(a)
    51(a)
    many ↔ many
    many ↔ many
    GL343260.1(1399329-1400123)
    1(132594652-132629594)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi24b062 wufi24b06 74(n)   333972  AW153648.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-836
    Putative protein phosphatase tag-83
    17(a)
    possible ortholog
    I(5600669-5603481)
            Species with no ortholog for TPTE

    ENSEMBL Gene Tree for TPTE (if available)
    TreeFam Gene Tree for TPTE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPTE gene
    PTEN2  DNAJC62  TNS12  TNS42  TNS32  TENC12  GAK2  TPTE22  
    4 SIMAP similar genes for TPTE using alignment to 2 protein entries:     TPTE_HUMAN (see all proteins):
    TPTE2    PTEN2    PTENP1    PTEN

    TPTE for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TPTE
    PGOHUM00000250333 PGOHUM00000249997


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2115 SNPs in TPTE are shown (see all 2115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365164
    A breast cancer sample4--see VAR_0365162 R Q mis40--------
    VAR_0650974
    ----see VAR_0650972 K E mis40--------
    rs589350541,2
    C--10906258(+) TACTTATC/-TTCAT 6 -- int1 cds11Minor allele frequency- -:0.50CSA 2
    rs1131654751,2
    C--10906258(+) TACTTA/C/TTCTTC 3 -- int10--------
    rs286167461,2
    C,F--10906293(+) CAACCC/G/TCCATG 3 -- int1 ese33NA WA 8
    rs29400491,2
    C,F--10906360(-) CACTCT/CCTTTC 3 -- int1 ese33Minor allele frequency- C:0.45NA CSA 11
    rs29861051,2
    F--10906361(+) AAAGGG/CAGTGT 3 -- int1 ese33Minor allele frequency- C:0.25NA 12
    rs1835191781,2
    --10906524(+) GTGAAC/TCAAAG 3 -- int10--------
    rs1865750791,2
    --10906703(+) ACTGTA/GAAGTA 3 -- int10--------
    rs1697571,2
    C,F,H--10906723(+) AAAAAA/CGAAGA 3 -- int1 trp311Minor allele frequency- C:0.11NS EA NA CSA 400

    HapMap Linkage Disequilibrium report for TPTE (10906201 - 11029719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for TPTE (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv992725CNV Deletion20482838
    esv2668163CNV Deletion23128226
    esv2661615CNV Deletion23128226
    esv1000174CNV Deletion20482838
    esv2657054CNV Deletion23128226
    nsv436336CNV Deletion17901297
    esv269554CNV Insertion20981092
    nsv438312CNV Loss16468122
    nsv437841CNV Loss16327808
    dgv67n17CNV Loss16327808


    Human Gene Mutation Database (HGMD): TPTE
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TPTE
    DNA2.0 Custom Variant and Variant Library Synthesis for TPTE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604336    OMIM disorders: --

    2 diseases for TPTE:    About MalaCards
    down syndrome    hepatocellular carcinoma


    TPTE for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPTE
    Human Genome Epidemiology (HuGE) Navigator: TPTE (1 document)

    Export disorders for TPTE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPTE gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TPTE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. (PubMed id 14659893)1, 2, 3, 9 Tapparel C.... Antonarakis S.E. (2003)
    2. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
    3. A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. (PubMed id 10598804)1, 2, 9 Chen H....Antonarakis S.E. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    8. Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome. (PubMed id 18074101)1 Shaw S.W....Hsieh F.J. (2008)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7179 HGNC: 12023 AceView: TPTE Ensembl:ENSG00000166157 euGenes: HUgn7179
    ECgene: TPTE H-InvDB: TPTE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPTE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TPTE gene:
    Search GeneIP for patents involving TPTE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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