Aliases for TPT1 Gene
External Ids for TPT1 Gene
Previous GeneCards Identifiers for TPT1 Gene
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
GeneCards Summary for TPT1 Gene
TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include Urticaria and Allergic Hypersensitivity Disease. Among its related pathways are DNA Damage and PLK1 signaling events. Gene Ontology (GO) annotations related to this gene include transcription factor binding.
UniProtKB/Swiss-Prot for TPT1 Gene
Involved in calcium binding and microtubule stabilization.