Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPT1 Gene

Aliases for TPT1 Gene

  • Tumor Protein, Translationally-Controlled 1 2 3
  • HRF 3 4 6
  • Histamine-Releasing Factor 3 4
  • Fortilin 3 4
  • TCTP 3 4
  • P23 3 4
  • Translationally-Controlled Tumor Protein 3
  • P02 3

External Ids for TPT1 Gene

Previous GeneCards Identifiers for TPT1 Gene

  • GC13M043911
  • GC13M039897
  • GC13M044847
  • GC13M043709
  • GC13M044810
  • GC13M044673
  • GC13M044815
  • GC13M044818
  • GC13M044821
  • GC13M044824
  • GC13M044827
  • GC13M044830
  • GC13M045912
  • GC13M045914
  • GC13M026712
  • GC13M045917
  • GC13M045921
  • GC13M045924
  • GC13M045937
  • GC13M045943
  • GC13M045955
  • GC13M045973

Summaries for TPT1 Gene

GeneCards Summary for TPT1 Gene

TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include mycetoma and malaria. Among its related pathways are Cytoskeletal Signaling and Cell Cycle / Checkpoint Control. GO annotations related to this gene include calcium ion binding and transcription factor binding.

UniProtKB/Swiss-Prot for TPT1 Gene

  • Involved in calcium binding and microtubule stabilization

Gene Wiki entry for TPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPT1 Gene

Genomics for TPT1 Gene

Regulatory Elements for TPT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPT1 Gene

Start:
45,333,471 bp from pter
End:
45,341,370 bp from pter
Size:
7,900 bases
Orientation:
Minus strand

Genomic View for TPT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPT1 Gene

Proteins for TPT1 Gene

  • Protein details for TPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13693-TCTP_HUMAN
    Recommended name:
    Translationally-controlled tumor protein
    Protein Accession:
    P13693
    Secondary Accessions:
    • B2R7E5
    • Q6YLS2
    • Q7Z4J4
    • Q8TBK7
    • Q96EE2
    • Q9UC70

    Protein attributes for TPT1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19595 Da
    Quaternary structure:
    • Interacts with STEAP3.

    Three dimensional structures from OCA and Proteopedia for TPT1 Gene

    Alternative splice isoforms for TPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPT1 Gene

Proteomics data for TPT1 Gene at MOPED

Post-translational modifications for TPT1 Gene

  • Ubiquitination at Lys102, Lys112, and Lys164
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TPT1 (TPT1)

No data available for DME Specific Peptides for TPT1 Gene

Domains for TPT1 Gene

Suggested Antigen Peptide Sequences for TPT1 Gene

Graphical View of Domain Structure for InterPro Entry

P13693

UniProtKB/Swiss-Prot:

TCTP_HUMAN :
  • P13693
Family:
  • Belongs to the TCTP family.
genes like me logo Genes that share domains with TPT1: view

No data available for Gene Families for TPT1 Gene

Function for TPT1 Gene

Molecular function for TPT1 Gene

GENATLAS Biochemistry: tumor protein,translationally controlled 1
UniProtKB/Swiss-Prot Function: Involved in calcium binding and microtubule stabilization
UniProtKB/Swiss-Prot Induction: Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15162379
GO:0005515 protein binding IPI 16730713
GO:0008134 transcription factor binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TPT1: view
genes like me logo Genes that share phenotypes with TPT1: view

Animal Models for TPT1 Gene

MGI Knock Outs for TPT1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TPT1 Gene

Localization for TPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPT1 Gene COMPARTMENTS Subcellular localization image for TPT1 gene
Compartment Confidence
endosome 5
extracellular 5
cytosol 3
nucleus 3
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15319436
GO:0005634 nucleus IDA 11598139
GO:0005654 nucleoplasm --
GO:0005737 cytoplasm TAS 16130169
GO:0005771 multivesicular body IDA 15319436
genes like me logo Genes that share ontologies with TPT1: view

Pathways for TPT1 Gene

genes like me logo Genes that share pathways with TPT1: view

Pathways by source for TPT1 Gene

1 BioSystems pathway for TPT1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IC 15958728
GO:0006874 cellular calcium ion homeostasis IC 15958728
GO:0009615 response to virus IEP 16548883
GO:0019827 stem cell maintenance --
GO:0042981 regulation of apoptotic process NAS 15162379
genes like me logo Genes that share ontologies with TPT1: view

Compounds for TPT1 Gene

(1) HMDB Compounds for TPT1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(13) Novoseek inferred chemical compound relationships for TPT1 Gene

Compound -log(P) Hits PubMed IDs
histamine 85.8 172
nedocromil sodium 56.8 2
rantes 51 2
fmlp 50.1 2
allergens 44 2
genes like me logo Genes that share compounds with TPT1: view

Transcripts for TPT1 Gene

Unigene Clusters for TPT1 Gene

Tumor protein, translationally-controlled 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPT1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: - - - -
SP9: - -

Relevant External Links for TPT1 Gene

GeneLoc Exon Structure for
TPT1
ECgene alternative splicing isoforms for
TPT1

Expression for TPT1 Gene

mRNA expression in normal human tissues for TPT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPT1 Gene

This gene is overexpressed in Muscle - Skeletal (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPT1 Gene

SOURCE GeneReport for Unigene cluster for TPT1 Gene Hs.374596

mRNA Expression by UniProt/SwissProt for TPT1 Gene

P13693-TCTP_HUMAN
Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
genes like me logo Genes that share expressions with TPT1: view

In Situ Assay Products

Orthologs for TPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPT1 35
  • 99.81 (n)
  • 100 (a)
TPT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
TPT1 35
  • 96.51 (n)
  • 99.42 (a)
TPT1 36
  • 99 (a)
OneToMany
TPT1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TPT1 35
  • 95.74 (n)
  • 100 (a)
TPT1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpt1 35
  • 90.31 (n)
  • 95.93 (a)
Tpt1 16
Tpt1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPT1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPT1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpt1 35
  • 90.7 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves TPT1 35
  • 84.88 (n)
  • 90.12 (a)
TPT1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPT1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tpt1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17076 35
tpt1 35
  • 70.54 (n)
  • 68.6 (a)
zebrafish
(Danio rerio)
Actinopterygii tctp 35
tpt1 35
  • 68.23 (n)
  • 67.25 (a)
tpt1 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TCTP_ANOGA 35
  • 56.69 (n)
  • 49.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tctp 35
  • 57.68 (n)
  • 52.1 (a)
Tctp 36
  • 48 (a)
OneToOne
CG4800 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea tct-1 35
  • 51.28 (n)
  • 40.24 (a)
tct-1 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR075C 35
  • 53.49 (n)
  • 43.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA19 35
  • 56.29 (n)
  • 43.11 (a)
TMA19 36
  • 43 (a)
OneToOne
TMA19 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12716g 35
  • 55.49 (n)
  • 44.91 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TCTP 35
  • 51.61 (n)
  • 39.76 (a)
rice
(Oryza sativa)
Liliopsida Os11g0660500 35
  • 51.81 (n)
  • 37.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06464 35
  • 54.69 (n)
  • 46.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F12.02c 35
  • 55.69 (n)
  • 50.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5297 36
  • 39 (a)
OneToOne
Species with no ortholog for TPT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPT1 Gene

ENSEMBL:
Gene Tree for TPT1 (if available)
TreeFam:
Gene Tree for TPT1 (if available)

Paralogs for TPT1 Gene

Selected SIMAP similar genes for TPT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPT1: view

No data available for Paralogs for TPT1 Gene

Variants for TPT1 Gene

Sequence variations from dbSNP and Humsavar for TPT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs729054 -- 45,335,277(+) GACTT(A/T)AATAG utr-variant-3-prime
rs1062421 -- 45,336,965(-) AACAT(A/C/T)TGAAG utr-variant-3-prime
rs2325216 -- 45,335,846(+) TTAGT(A/G)TCTGC utr-variant-3-prime
rs3196907 -- 45,333,478(-) AGAAC(A/C)CTGAT utr-variant-3-prime
rs4545704 -- 45,334,032(+) TCTCT(C/T)GGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPT1 Gene

Variant ID Type Subtype PubMed ID
nsv510579 CNV Loss 20534489

Relevant External Links for TPT1 Gene

HapMap Linkage Disequilibrium report
TPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPT1 Gene

Disorders for TPT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TPT1 Gene including...

Search for TPT1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for TPT1 Gene

(24) Novoseek inferred disease relationships for TPT1 Gene

Disease -log(P) Hits PubMed IDs
urticaria chronic 76.3 4
idiopathic urticaria 73.8 9
urticaria 57.1 3
asthma 50 22
allergic rhinitis 45.4 3

Relevant External Links for TPT1

Genetic Association Database (GAD)
TPT1
Human Genome Epidemiology (HuGE) Navigator
TPT1
genes like me logo Genes that share disorders with TPT1: view

No data available for UniProtKB/Swiss-Prot for TPT1 Gene

Publications for TPT1 Gene

  1. Molecular identification of an IgE-dependent histamine-releasing factor. (PMID: 7542803) MacDonald S.M. … Lichtenstein L.M. (Science 1995) 3 4 23
  2. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PMID: 9059837) Sanchez J.-C. … Hochstrasser D.F. (Electrophoresis 1997) 3 4 23
  3. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PMID: 10343127) MacDonald S.M. … Jabs E.W. (Cytogenet. Cell Genet. 1999) 2 3 23
  4. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PMID: 12167714) Yarm F.R. (Mol. Cell. Biol. 2002) 3 4 23
  5. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PMID: 15162379) Arcuri F. … del Vecchio M.T. (Prostate 2004) 3 4 23

Products for TPT1 Gene

  • Addgene plasmids for TPT1

Sources for TPT1 Gene

Back to Top

Content