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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPT1 Gene

protein-coding   GIFtS: 62
GCID: GC13M045943

tumor protein, translationally-controlled 1
 Explore 51 diseases affiliated with
TPT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TPT1    

Aliases
for TPT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tumor Protein, Translationally-Controlled 11 2     P231
TCTP1 2 3     P021
HRF2 3 5     Translationally-Controlled Tumor Protein2
Fortilin3     Fortilin3
Histamine-Releasing Factor2 3     

External Ids:    HGNC: 120221   Entrez Gene: 71782   Ensembl: ENSG000001331127   OMIM: 6007635   UniProtKB: P136933   

Export aliases for TPT1 gene to outside databases

Previous GC identifers: GC13M043911 GC13M039897 GC13M044847 GC13M043709 GC13M044810 GC13M044673 GC13M044815 GC13M044818 GC13M044821 GC13M044824 GC13M044827 GC13M044830 GC13M045912 GC13M045914 GC13M026712 GC13M045917 GC13M045921 GC13M045924 GC13M045937


Summaries
for TPT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
Function: Involved in calcium binding and microtubule stabilization

Gene Wiki entry for TPT1


Genomic Views
for TPT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPT1 gene promoter:
         CREB   deltaCREB   AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TPT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14

TPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPT1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M045943:  view genomic region     (about GC identifiers)

Start:
 45,911,008 bp from pter      End:
 45,915,505 bp from pter
Size:
 4,498 bases      Orientation:
 minus strand

Proteins
for TPT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693 (See protein sequence)
Recommended Name: Translationally-controlled tumor protein  
Size: 172 amino acids; 19595 Da
Subunit: Interacts with STEAP3
Subcellular location: Cytoplasm
3 PDB 3D structures from and Proteopedia for TPT1:
1YZ1 (3D)        2HR9 (3D)        3EBM (3D)    
Secondary accessions: B2R7E5 Q6YLS2 Q7Z4J4 Q96EE2 Q9UC70

Explore the universe of human proteins at neXtProt for TPT1: NX_P13693

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13693

    • TPT1 Protein expression data from MOPED and PaxDb:    About this image 
    TPT1 Protein Expression
    REFSEQ proteins: NP_003286.1  
    ENSEMBL proteins: 
     ENSP00000368345   ENSP00000433091   ENSP00000432457   ENSP00000431872   ENSP00000368350  
     ENSP00000368344   ENSP00000339051   ENSP00000433738  

    Human Recombinant Protein Products for TPT1: 
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    Novus Biologicals TPT1 Proteins
    Novus Biologicals TPT1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TPT1
    Uscn Proteins for TPT1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA15319436
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0005771multivesicular body IDA15319436
    GO:0045298colocalizes with tubulin complex IDA15162379

    TPT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TPT1

    Protein Domains /
    Families
    for TPT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TPT1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018105 Translational_control_tumour_p
     IPR011323 Mss4/transl-control_tumor
     IPR018103 Translation_control_tumour_CS
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry P13693

    ProtoNet protein and cluster: P13693

    1 Blocks protein family: IPB001983 Translationally controlled tumor protein

    UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
    Similarity: Belongs to the TCTP family


    Function
    for TPT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCTP_HUMAN, P13693
    Function: Involved in calcium binding and microtubule stabilization
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for TPT1:
    tumor protein,translationally controlled 1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA15162379
    GO:0008134transcription factor binding IEA--
         
    TPT1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TPT1:
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tpt1):
     cellular  embryogenesis  growth/size  mortality/aging  normal 

    TPT1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for TPT1: Tpt1tm1.1Yen Tpt1tm1.1Atel
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TPT1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: TPT1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TPT1


    Pathways & Interactions
    for TPT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    2Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    3Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    4PLK1 signaling events
    		PLK1 signaling events1.00
    5Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4 Cell Signaling Technology (CST) Pathways for TPT1
        Cell Cycle / Checkpoint Control
    Ca, cAMP and Lipid Signaling
    Cytoskeletal Signaling
    Lymphocyte Signaling

    1 BioSystems Pathway for TPT1 
        PLK1 signaling events



    TPT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for TPT1 (P136932, 3 ENSP000003683504) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IC15958728
    GO:0006874cellular calcium ion homeostasis IC15958728
    GO:0009615response to virus IEP16548883
    GO:0019827stem cell maintenance IEA--
    GO:0042981regulation of apoptotic process NAS15162379

    TPT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TPT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPT1

    1 HMDB Compound for TPT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/13 Novoseek chemical compound relationships for TPT1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 85.8 289 8970437 (7), 8842556 (5), 1371775 (4), 1716285 (4) (see all 99)
    nedocromil sodium 56.8 2 8754956 (1), 9760791 (1)
    rantes 51 2 1382479 (2)
    fmlp 50.1 4 18322233 (1), 1702129 (1)
    allergens 44 2 1878139 (1), 17024353 (1)
    artemisinin 23.9 2 16491843 (1), 15878303 (1)
    calcium 13 50 17705784 (7), 10477280 (5), 15958728 (5), 15162379 (4) (see all 8)
    guanine 10.7 3 11473261 (1), 15062873 (1)
    histidine 9.66 9 19697087 (2), 11985867 (2)
    lactate 5.29 4 1695233 (1), 1376736 (1), 1708690 (1)

    Search CenterWatch for drugs/clinical trials and news about TPT1 / TCTP 

    Transcripts
    for TPT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TPT1 gene: 
    NM_003295.2  

    Unigene Cluster for TPT1:

    Tumor protein, translationally-controlled 1
    Hs.374596  [show with all ESTs]
    Unigene Representative Sequence: BG033621
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379056(uc001uzz.1) ENST00000528619 ENST00000529421 ENST00000484604
    ENST00000533567 ENST00000490277 ENST00000530245 ENST00000530705(uc001uzy.1)
    ENST00000379060 ENST00000379055 ENST00000309246 ENST00000527226 ENST00000442760(uc010tfp.1)


    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TPT1:
    hsa-miR-3691-5p hsa-miR-1910 hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TPT1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TPT1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK130847.1 AK296587.1 AK296952.1 AK312951.1 AY117678.1 AY334563.1 AY952884.2 BC003352.2 
    BC007842.1 BC012431.1 BC022436.1 BC040008.1 BC052333.1 CR457036.1 L13806.1 X16064.1 
    X64899.1 

    24/146 DOTS entries (see all 146):

    DT.91781826  DT.100733394  DT.100733431  DT.100733370  DT.91781857  DT.100733383  DT.100733424  DT.100733358 
    DT.87018221  DT.91781818  DT.97869274  DT.91781854  DT.100733416  DT.120768188  DT.100733395  DT.120768288 
    DT.95371615  DT.100733363  DT.91679216  DT.100875372  DT.100733356  DT.120768190  DT.120768345  DT.100733412 

    24/4717 AceView cDNA sequences (see all 4717):

    BM311666 T63749 BG402975 BP871171 BE714308 CB177891 BM831892 AU150428 
    H69495 AA313747 BQ431963 CR618209 BG654848 CF528090 CR626131 BM833366 
    BU949640 BM478521 CA772177 BE773367 CA393444 BI712868 AW675495 BQ030372 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:        -           -     -                 -     -                             -                     
    SP2:                    -     -                 -     -                                                   
    SP3:                                            -     -                                                   
    SP4:        -           -     -                                                                           
    SP5:        -           -                                                                                 


    ECgene alternative splicing isoforms for TPT1

    Expression
    for TPT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGTTGTCT
    TPT1 Expression
    About this image

    TPT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TPT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPT1

    SOURCE GeneReport for Unigene cluster: Hs.374596

    UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
    Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages,
    platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be
    detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate

        SABiosciences Expression via Pathway-Focused PCR Array including TPT1: 
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    In Situ
    Assay Products:     
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    Orthologs
    for TPT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPT1 gene from 10/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tpt11 , 5 tumor protein, translationally-controlled 11, 5 90.31(n)1
    95.93(a)1    		   14 (40.29 cM)5
    220701  NM_009429.31  NP_033455.11 
     758450935 
    chicken
    (Gallus gallus)    		 Aves TPT11 tumor protein, translationally-controlled 1 84.88(n)
    90.12(a)    		   396363  NM_205398.1  NP_990729.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TPT16
    		 --
    		 84(a)
    		 1 ↔ 1
    		 GL343395.1(755216-762832)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tpt1-prov2 tumor protein, translationally-controlled 1 74.32(n)    BC043811.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tctp2 translationally controlled tumor protein 76.21(n)   30723  AF288217.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG48003
    Tctp1    		 Translationally controlled tumor protein1 48(a)3
    57.29(n)1
    51.5(a)1    		   86D93
    413411  NM_141791.21  NP_650048.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea tct-11 Protein TCT-1 50.89(n)
    40.24(a)    		   172944  NM_060366.4  NP_492767.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TMA19(YKL056C)4
    TMA191    		 Protein that associates with ribosomes; homolog of more4
    Tma19p1    		 56.63(n)1
    43.37(a)1    		   11(334915-334412)4
    8538091, 4  NP_012867.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TCTP6
    AT3G055406
    		 translationally-controlled tumor protein-like prot...
    Methionine sulfoxide reductase (MSS4-like) protein...
    		 36(a)
    34(a)
    		 many → 1
    many → 1
    		 3(5669373-5670842)
    3(1606487-1608030)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 translationally-controlled tumor protein, putative...
    		 36(a)
    		 1 ↔ 1
    		 11(26039285-26041549)


    ENSEMBL Gene Tree for TPT1 (if available)
    TreeFam Gene Tree for TPT1 (if available) 

    Paralogs
    for TPT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPT1 gene

    TPT1 for paralogs           About GeneDecksing


    5/17 Pseudogenes.org Pseudogenes for TPT1 (see all 17)
    PGOHUM00000257781 PGOHUM00000258615 PGOHUM00000258122 PGOHUM00000239988 PGOHUM00000258137


    Genomic Variants
    for TPT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/165 NCBI SNPs in TPT1 are shown (see all 165)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1407651071,2
    		--45910968(+) GACTTC/TGCTCT 1 -- ds50010--------
    rs1128320191,2
    		C--45911000(+) ACAAAC/G/TTTGCT 1 -- ds50011CSA 1
    rs770322391,2
    		--45911095(+) CCACAC/TTTCAG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs10624201,2
    		C,F,H--45911171(-) AATATA/GAAAAA 2 -- ds500115Minor allele frequency- G:0.14NS EA NA WA 1972
    rs1501260041,2
    		--45911187(+) CCCAGA/TAGTAG 2 -- ds50010--------
    rs1385822941,2
    		--45911377(+) GCCTCA/CACTCC 2 -- ds5001 ut310--------
    rs22342271,2
    		C,F,A,H--45911482(-) TCATCA/CTAACT 2 -- ut31 ds500114Minor allele frequency- C:0.03NS EA NA CSA WA 966
    rs2017967411,2
    		C--45911509(+) AATAAT/CTGCCA 2 -- ds5001 ut311Minor allele frequency- C:0.00EU 1321
    rs1492994361,2
    		--45911892(+) CTGTCC/TACTGT 2 -- int1 us2k10--------
    rs21475031,2
    		C,F,O,A,H--45911932(-) GAAGAA/GAAACA 2 -- int1 us2k1 trp329Minor allele frequency- G:0.49NS EA NA WA CSA 2579

    HapMap Linkage Disequilibrium report for TPT1 (45911008 - 45915505 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TPT1: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TPT1

    Disorders / Diseases
    for TPT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TPT1 for disorders           About GeneDecksing

    OMIM gene information: 600763    OMIM disorders: --

    20/51 diseases for TPT1 (see all 51):    About MalaCards
    paraneoplastic cerebellar degeneration    posterior myocardial infarction    urticaria    allergic rhinitis
    cerebellar degeneration    type 1 diabetes mellitus    rhinitis    mycetoma
    diabetes mellitus    bronchial asthma    pericarditis    allergic asthma
    fanconi's anemia    asthma    atopy    myocardial infarction
    renal cell carcinoma    nephrotic syndrome    pulmonary fibrosis    multiple myeloma

    1 disease from the University of Copenhagen DISEASES database for TPT1:
    Urticaria

    10/24 Novoseek disease relationships for TPT1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urticaria chronic 76.3 4 8970437 (1), 17509061 (1), 19585861 (1), 16076300 (1)
    idiopathic urticaria 73.8 10 8970437 (5), 8842556 (2), 12877454 (1), 7687607 (1)
    urticaria 57.1 4 7600377 (1), 15725248 (1), 19585861 (1)
    asthma 50 27 7522854 (2), 1702128 (2), 19585861 (2), 8711735 (1) (see all 19)
    allergic rhinitis 45.4 3 1375820 (1), 7508179 (1), 7687607 (1)
    allergy 45.1 3 16491843 (1), 10200014 (1), 19484128 (1)
    allergic reaction 40.3 3 12487227 (2), 19484128 (1)
    allergy drug 40.1 2 12876410 (1), 17460952 (1)
    bronchial hyperreactivity 38.7 2 8814942 (1)
    tumors 37.1 99 15489264 (4), 10880768 (3), 18630514 (2), 9588028 (2) (see all 55)

    Human Genome Epidemiology (HuGE) Navigator: TPT1 (3 documents)

    Export disorders for TPT1 gene to outside databases

    Publications
    for TPT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPT1 gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with TPT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence coding for a translationally controlled human tumor protein. (PubMed id 2813067)1, 2, 3 Gross B.... Bielka H. (1989)
    2. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PubMed id 15958728)1, 2, 9 Arcuri F.... Cintorino M. (2005)
    3. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PubMed id 15162379)1, 2, 9 Arcuri F.... del Vecchio M.T. (2004)
    4. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PubMed id 12167714)1, 2, 9 Yarm F.R. (2002)
    5. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PubMed id 9059837)1, 2, 9 Sanchez J.-C.... Hochstrasser D.F. (1997)
    6. Chromosomal localization of tumor protein, translatio nally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) t o 13q12-->q14. (PubMed id 10343127)1, 3, 9 MacDonald S.M....Jabs E.W. (1999)
    7. Molecular identification of an IgE-dependent histamine-releasing factor. (PubMed id 7542803)1, 2, 9 MacDonald S.M.... Lichtenstein L.M. (1995)
    8. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    10. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PubMed id 15319436)1, 2 Amzallag N.... Telerman A. (2004)

    External Searches for TPT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing TPT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7178 HGNC: 12022 AceView: TPT1 Ensembl:ENSG00000133112 euGenes: HUgn7178
    ECgene: TPT1 H-InvDB: TPT1

    Other Databases showing TPT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TPT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPT1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TPT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TPT1 gene:
    Search GeneIP for patents involving TPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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