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Aliases for TPT1 Gene

Aliases for TPT1 Gene

  • Tumor Protein, Translationally-Controlled 1 2 3 5
  • Histamine-Releasing Factor 3 4
  • Fortilin 3 4
  • TCTP 3 4
  • P23 3 4
  • HRF 3 4
  • P02 3

External Ids for TPT1 Gene

Previous GeneCards Identifiers for TPT1 Gene

  • GC13M043911
  • GC13M039897
  • GC13M044847
  • GC13M043709
  • GC13M044810
  • GC13M044673
  • GC13M044815
  • GC13M044818
  • GC13M044821
  • GC13M044824
  • GC13M044827
  • GC13M044830
  • GC13M045912
  • GC13M045914
  • GC13M026712
  • GC13M045917
  • GC13M045921
  • GC13M045924
  • GC13M045937
  • GC13M045943
  • GC13M045955
  • GC13M045973

Summaries for TPT1 Gene

GeneCards Summary for TPT1 Gene

TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include urticaria and allergic hypersensitivity disease. Among its related pathways are PLK1 signaling events. GO annotations related to this gene include poly(A) RNA binding and transcription factor binding.

UniProtKB/Swiss-Prot for TPT1 Gene

  • Involved in calcium binding and microtubule stabilization.

Gene Wiki entry for TPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPT1 Gene

Genomics for TPT1 Gene

Regulatory Elements for TPT1 Gene

Promoters for TPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPT1 Gene

Chromosome:
13
Start:
45,333,471 bp from pter
End:
45,341,370 bp from pter
Size:
7,900 bases
Orientation:
Minus strand

Genomic View for TPT1 Gene

Genes around TPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPT1 Gene

Proteins for TPT1 Gene

  • Protein details for TPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13693-TCTP_HUMAN
    Recommended name:
    Translationally-controlled tumor protein
    Protein Accession:
    P13693
    Secondary Accessions:
    • B2R7E5
    • Q6YLS2
    • Q7Z4J4
    • Q8TBK7
    • Q96EE2
    • Q9UC70

    Protein attributes for TPT1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19595 Da
    Quaternary structure:
    • Interacts with STEAP3.

    Three dimensional structures from OCA and Proteopedia for TPT1 Gene

    Alternative splice isoforms for TPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TPT1 Gene

Proteomics data for TPT1 Gene at MOPED

Post-translational modifications for TPT1 Gene

  • Ubiquitination at Lys 102 and Lys 164
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TPT1 (TPT1)

No data available for DME Specific Peptides for TPT1 Gene

Domains & Families for TPT1 Gene

Suggested Antigen Peptide Sequences for TPT1 Gene

Graphical View of Domain Structure for InterPro Entry

P13693

UniProtKB/Swiss-Prot:

TCTP_HUMAN :
  • Belongs to the TCTP family.
Family:
  • Belongs to the TCTP family.
genes like me logo Genes that share domains with TPT1: view

No data available for Gene Families for TPT1 Gene

Function for TPT1 Gene

Molecular function for TPT1 Gene

GENATLAS Biochemistry:
tumor protein,translationally controlled 1
UniProtKB/Swiss-Prot Function:
Involved in calcium binding and microtubule stabilization.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15162379
genes like me logo Genes that share ontologies with TPT1: view
genes like me logo Genes that share phenotypes with TPT1: view

Animal Models for TPT1 Gene

MGI Knock Outs for TPT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPT1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPT1 Gene

Localization for TPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPT1 Gene COMPARTMENTS Subcellular localization image for TPT1 gene
Compartment Confidence
endosome 5
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IDA,TAS 16130169
GO:0045298 colocalizes_with tubulin complex IDA 15162379
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with TPT1: view

Pathways & Interactions for TPT1 Gene

SuperPathways for TPT1 Gene

Superpath Contained pathways
1 PLK1 signaling events
genes like me logo Genes that share pathways with TPT1: view

Pathways by source for TPT1 Gene

1 BioSystems pathway for TPT1 Gene

SIGNOR curated interactions for TPT1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IC 15958728
GO:0043066 negative regulation of apoptotic process TAS 16130169
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 11598139
GO:2000384 negative regulation of ectoderm development IEA --
genes like me logo Genes that share ontologies with TPT1: view

Drugs & Compounds for TPT1 Gene

(8) Drugs for TPT1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for TPT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPT1: view

Transcripts for TPT1 Gene

Unigene Clusters for TPT1 Gene

Tumor protein, translationally-controlled 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:
SP7: -
SP8: - - - -
SP9: - -

Relevant External Links for TPT1 Gene

GeneLoc Exon Structure for
TPT1
ECgene alternative splicing isoforms for
TPT1

Expression for TPT1 Gene

mRNA expression in normal human tissues for TPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for TPT1 Gene

This gene is overexpressed in Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPT1 Gene



SOURCE GeneReport for Unigene cluster for TPT1 Gene Hs.374596

mRNA Expression by UniProt/SwissProt for TPT1 Gene

P13693-TCTP_HUMAN
Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
genes like me logo Genes that share expression patterns with TPT1: view

Protein tissue co-expression partners for TPT1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TPT1 Gene

Orthologs for TPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPT1 35
  • 96.51 (n)
  • 99.42 (a)
-- 36
  • 97 (a)
OneToMany
TPT1 36
  • 99 (a)
OneToMany
TPT1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TPT1 35
  • 95.74 (n)
  • 100 (a)
TPT1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpt1 35
  • 90.31 (n)
  • 95.93 (a)
Tpt1 16
Tpt1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPT1 35
  • 99.81 (n)
  • 100 (a)
TPT1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpt1 35
  • 90.7 (n)
  • 95.93 (a)
oppossum
(Monodelphis domestica)
Mammalia TPT1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPT1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPT1 35
  • 84.88 (n)
  • 90.12 (a)
TPT1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TPT1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17076 35
tpt1 35
  • 70.54 (n)
  • 68.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia tpt1-prov 35
zebrafish
(Danio rerio)
Actinopterygii tctp 35
tpt1 35
  • 68.23 (n)
  • 67.25 (a)
tpt1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4800 37
  • 48 (a)
Tctp 35
  • 57.68 (n)
  • 52.1 (a)
Tctp 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TCTP_ANOGA 35
  • 56.69 (n)
  • 49.7 (a)
worm
(Caenorhabditis elegans)
Secernentea tct-1 35
  • 51.28 (n)
  • 40.24 (a)
tct-1 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR075C 35
  • 53.49 (n)
  • 43.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12716g 35
  • 55.49 (n)
  • 44.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA19 35
  • 56.29 (n)
  • 43.11 (a)
TMA19 36
  • 43 (a)
OneToOne
TMA19 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TCTP 35
  • 51.61 (n)
  • 39.76 (a)
rice
(Oryza sativa)
Liliopsida Os11g0660500 35
  • 51.81 (n)
  • 37.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06464 35
  • 54.69 (n)
  • 46.71 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F12.02c 35
  • 55.69 (n)
  • 50.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5297 36
  • 39 (a)
OneToOne
Species with no ortholog for TPT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPT1 Gene

ENSEMBL:
Gene Tree for TPT1 (if available)
TreeFam:
Gene Tree for TPT1 (if available)

Paralogs for TPT1 Gene

(1) SIMAP similar genes for TPT1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TPT1: view

No data available for Paralogs for TPT1 Gene

Variants for TPT1 Gene

Sequence variations from dbSNP and Humsavar for TPT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_052273 -
rs729054 -- 45,335,277(+) GACTT(A/T)AATAG utr-variant-3-prime
rs1062421 -- 45,336,965(-) AACAT(A/C/T)TGAAG utr-variant-3-prime
rs2325216 -- 45,335,846(+) TTAGT(A/G)TCTGC utr-variant-3-prime
rs3196907 -- 45,333,478(-) AGAAC(A/C)CTGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPT1 Gene

Variant ID Type Subtype PubMed ID
nsv510579 CNV Loss 20534489

Variation tolerance for TPT1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPT1 Gene

HapMap Linkage Disequilibrium report
TPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPT1 Gene

Disorders for TPT1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for TPT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
urticaria
allergic hypersensitivity disease
  • allergic disease
asthma
  • asthma, protection against
paraneoplastic cerebellar degeneration
mycetoma
  • madura foot
- elite association - COSMIC cancer census association via MalaCards
Search TPT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPT1

Genetic Association Database (GAD)
TPT1
Human Genome Epidemiology (HuGE) Navigator
TPT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPT1
genes like me logo Genes that share disorders with TPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPT1 Gene

Publications for TPT1 Gene

  1. cDNA sequence coding for a translationally controlled human tumor protein. (PMID: 2813067) Gross B. … Bielka H. (Nucleic Acids Res. 1989) 2 3 4 67
  2. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PMID: 10343127) MacDonald S.M. … Jabs E.W. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. The role of translationally controlled tumor protein in tumor growth and metastasis of colon adenocarcinoma cells. (PMID: 19621893) Ma Q. … Li M. (J. Proteome Res. 2010) 3 23
  4. H2O2-dependent translocation of TCTP into the nucleus enables its interaction with VDR in human keratinocytes: TCTP as a further module in calcitriol signalling. (PMID: 19815065) Rid R. … Breitenbach M. (J. Steroid Biochem. Mol. Biol. 2010) 3 23
  5. Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells. (PMID: 19360337) Gnanasekar M. … Ramaswamy K. (Int. J. Oncol. 2009) 3 23

Products for TPT1 Gene

Sources for TPT1 Gene

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