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TPT1 Gene

protein-coding   GIFtS: 69
GCID: GC13M045973

Tumor Protein, Translationally-Controlled 1

  See TPT1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Protein, Translationally-Controlled 11 2     fortilin2
HRF2 3 5     p022
Histamine-Releasing Factor2 3     Translationally-Controlled Tumor Protein2
TCTP2 3     Fortilin3
p232 3     

External Ids:    HGNC: 120221   Entrez Gene: 71782   Ensembl: ENSG000001331127   OMIM: 6007635   UniProtKB: P136933   

Export aliases for TPT1 gene to outside databases

Previous GC identifers: GC13M043911 GC13M039897 GC13M044847 GC13M043709 GC13M044810 GC13M044673 GC13M044815 GC13M044818 GC13M044821 GC13M044824 GC13M044827 GC13M044830 GC13M045912 GC13M045914 GC13M026712 GC13M045917 GC13M045921 GC13M045924 GC13M045937 GC13M045943 GC13M045955


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPT1 Gene:
TPT1 (tumor protein, translationally-controlled 1) is a protein-coding gene. Diseases associated with TPT1 include mycetoma. GO annotations related to this gene include transcription factor binding and calcium ion binding.

UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
Function: Involved in calcium binding and microtubule stabilization

Gene Wiki entry for TPT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPT1 gene promoter:
         CREB   deltaCREB   AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TPT1 promoter sequence
   Search Chromatin IP Primers for TPT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.13   HGNC cytogenetic band: 13q14

TPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPT1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M045973:  view genomic region     (about GC identifiers)

Start:
45,911,008 bp from pter      End:
45,915,505 bp from pter
Size:
4,498 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693 (See protein sequence)
Recommended Name: Translationally-controlled tumor protein  
Size: 172 amino acids; 19595 Da
Subunit: Interacts with STEAP3
3 PDB 3D structures from and Proteopedia for TPT1:
1YZ1 (3D)        2HR9 (3D)        3EBM (3D)    
Secondary accessions: B2R7E5 Q6YLS2 Q7Z4J4 Q96EE2 Q9UC70

Explore the universe of human proteins at neXtProt for TPT1: NX_P13693

Explore proteomics data for TPT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys102, Lys112, Lys164
  • Modification sites at PhosphoSitePlus

  • See TPT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273201.1  NP_001273202.1  NP_003286.1  

    ENSEMBL proteins: 
     ENSP00000368345   ENSP00000433091   ENSP00000432457   ENSP00000431872   ENSP00000368350  
     ENSP00000368344   ENSP00000339051   ENSP00000433738  

    TPT1 Human Recombinant Protein Products:

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    Novus Biologicals TPT1 Proteins
    Novus Biologicals TPT1 Lysate
    Sino Biological Recombinant Protein for TPT1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TPT1
    Cloud-Clone Corp. Proteins for TPT1

     
    Search eBioscience for Proteins for TPT1 

    TPT1 Antibody Products:

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    TPT1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TPT1
    Cloud-Clone Corp. CLIAs for TPT1
    Search eBioscience for ELISAs for TPT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR018105 Translational_control_tumour_p
     IPR011323 Mss4/transl-control_tumor
     IPR018103 Translation_control_tumour_CS
     IPR011057 Mss4-like

    Graphical View of Domain Structure for InterPro Entry P13693

    ProtoNet protein and cluster: P13693

    1 Blocks protein domain: IPB001983 Translationally controlled tumor protein

    UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
    Similarity: Belongs to the TCTP family


    Find genes that share domains with TPT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCTP_HUMAN, P13693
    Function: Involved in calcium binding and microtubule stabilization
    Induction: Down-regulated in response to enterovirus 71 (EV71) infection

         Genatlas biochemistry entry for TPT1:
    tumor protein,translationally controlled 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA15162379
    GO:0005515protein binding IPI16730713
    GO:0008134transcription factor binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TPT1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TPT1:
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tpt1):
     cellular  embryogenesis  growth/size/body  mortality/aging  normal 

    Find genes that share phenotypes with TPT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TPT1: Tpt1tm1.1Yen Tpt1tm1.1Atel

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPT1:
    hsa-mir-3200-3p (MIRT052823), hsa-mir-374b-5p (MIRT036803), hsa-mir-16-5p (MIRT031462), hsa-let-7b-5p (MIRT052061), hsa-mir-92a-3p (MIRT048923), hsa-mir-29b-3p (MIRT048369), hsa-mir-615-3p (MIRT039903), hsa-mir-92b-3p (MIRT040607)

    Block miRNA regulation of human, mouse, rat TPT1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TPT1:
    hsa-miR-3691-5p hsa-miR-1910 hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TPT1
    Predesigned siRNA for gene silencing in human, mouse, rat TPT1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TPT1 (NM_003295)
    Sino Biological Human cDNA Clone for TPT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPT1
    Addgene plasmids for TPT1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCTP_HUMAN, P13693: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    extracellular5
    cytosol3
    nucleus3
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA15319436
    GO:0005634nucleus IDA11598139
    GO:0005654nucleoplasm IEA--
    GO:0005737cytoplasm TAS16130169
    GO:0005771multivesicular body IDA15319436

    Find genes that share ontologies with TPT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TPT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2PLK1 signaling events
    PLK1 signaling events
    3Lymphocyte Signaling
    Lymphocyte Signaling
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with TPT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Cell Signaling Technology (CST) Pathways for TPT1
        Cell Cycle / Checkpoint Control
    Ca, cAMP and Lipid Signaling
    Cytoskeletal Signaling
    Lymphocyte Signaling

    1 BioSystems Pathway for TPT1
        PLK1 signaling events



        Pathway & Disease-focused RT2 Profiler PCR Array including TPT1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TPT1 (P136931, 2, 3 ENSP000003683504) via UniProtKB, MINT, STRING, and/or I2D (see all 192)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006816calcium ion transport IC15958728
    GO:0006874cellular calcium ion homeostasis IC15958728
    GO:0009615response to virus IEP16548883
    GO:0019827stem cell maintenance IEA--
    GO:0042981regulation of apoptotic process NAS15162379

    Find genes that share ontologies with TPT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPT1 (TCTP)

    1 HMDB Compound for TPT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for TPT1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    histamine 85.8 289 8970437 (7), 8842556 (5), 1371775 (4), 1716285 (4) (see all 99)
    nedocromil sodium 56.8 2 8754956 (1), 9760791 (1)
    rantes 51 2 1382479 (2)
    fmlp 50.1 4 18322233 (1), 1702129 (1)
    allergens 44 2 1878139 (1), 17024353 (1)
    artemisinin 23.9 2 16491843 (1), 15878303 (1)
    calcium 13 50 17705784 (7), 10477280 (5), 15958728 (5), 15162379 (4) (see all 8)
    guanine 10.7 3 11473261 (1), 15062873 (1)
    histidine 9.66 9 19697087 (2), 11985867 (2)
    lactate 5.29 4 1695233 (1), 1376736 (1), 1708690 (1)



    Find genes that share compounds with TPT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPT1 gene (3 alternative transcripts): 
    NM_001286272.1  NM_001286273.1  NM_003295.3  

    Unigene Cluster for TPT1:

    Tumor protein, translationally-controlled 1
    Hs.374596  [show with all ESTs]
    Unigene Representative Sequence: BG033621
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379056(uc001uzz.1) ENST00000528619 ENST00000529421 ENST00000484604
    ENST00000533567 ENST00000490277 ENST00000530245 ENST00000530705(uc001uzy.1)
    ENST00000379060 ENST00000379055 ENST00000309246 ENST00000527226 ENST00000442760(uc010tfp.1)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TPT1:
    hsa-miR-3691-5p hsa-miR-1910 hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPT1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TPT1 (NM_003295)
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    OriGene qSTAR qPCR primer pairs in human, mouse for TPT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TPT1
      QuantiTect SYBR Green Assays in human, mouse, rat TPT1
      QuantiFast Probe-based Assays in human, mouse, rat TPT1

    Additional mRNA sequence: 

    AJ609441.1 AK130847.1 AK296587.1 AK296952.1 AK312951.1 AY117678.1 AY334563.1 AY952884.2 
    BC003352.2 BC007842.1 BC012431.1 BC022436.1 BC040008.1 BC052333.1 CR457036.1 L13806.1 
    NR_002967.1 X16064.1 X64899.1 

    Selected DOTS entries (see all 149):

    DT.91781826  DT.100733394  DT.100733431  DT.100733370  DT.100733383  DT.91781857  DT.100733424  DT.100733358 
    DT.87018221  DT.91781818  DT.97869274  DT.91781854  DT.100733416  DT.120768188  DT.100733395  DT.120768288 
    DT.95371615  DT.100733363  DT.91679216  DT.100733356  DT.100875372  DT.120768190  DT.120768345  DT.100733380 

    Selected AceView cDNA sequences (see all 4717):

    AV709784 CA868101 BM823224 BQ787974 BE889630 BE302334 AV654325 CB110614 
    AA186679 CA771757 BI491073 BU630939 BM752399 CA307288 BM833656 CA420052 
    BX494325 BG575232 AA086325 CD107541 CA777784 BM769295 BE172549 BG402975 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:        -           -     -                 -     -                             -                     
    SP2:                    -     -                 -     -                                                   
    SP3:                                            -     -                                                   
    SP4:        -           -     -                                                                           
    SP5:        -           -                                                                                 


    ECgene alternative splicing isoforms for TPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGTTGTCT
    TPT1 Expression
    About this image


    TPT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
    TPT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374596

    UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
    Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages,
    platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be
    detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate

        Pathway & Disease-focused RT2 Profiler PCR Array including TPT1: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TPT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TPT1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpt11 , 5 tumor protein, translationally-controlled 11, 5 90.31(n)1
    95.93(a)1
      14 (40.29 cM)5
    220701  NM_009429.31  NP_033455.11 
     758450935 
    chicken
    (Gallus gallus)
    Aves TPT11 tumor protein, translationally-controlled 1 84.88(n)
    90.12(a)
      396363  NM_205398.1  NP_990729.1 
    lizard
    (Anolis carolinensis)
    Reptilia TPT16
    tumor protein, translationally-controlled 1
    85(a)
    1 ↔ 1
    GL343395.1(752776-762832)
    African clawed frog
    (Xenopus laevis)
    Amphibia tpt1-prov2 tumor protein, translationally-controlled 1 74.32(n)    BC043811.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tctp2 translationally controlled tumor protein 76.21(n)   30723  AF288217.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48003
    Tctp1
    Translationally controlled tumor protein1 48(a)3
    57.68(n)1
    52.1(a)1
      86D93
    413411  NM_141791.31  NP_650048.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tct-11 tct-1 51.28(n)
    40.24(a)
      172944  NM_060366.5  NP_492767.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TMA19(YKL056C)4
    TMA191
    Protein that associates with ribosomes; homolog of more4
    TMA191
    56.29(n)1
    43.11(a)1
      11(334915-334412)4
    8538091, 4  NP_012867.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TCTP1 TCTP 51.61(n)
    39.76(a)
      820916  NM_112537.3  NP_188286.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06605001 Os11g0660500 51.81(n)
    37.95(a)
      4351061  NM_001074937.1  NP_001068405.1 


    ENSEMBL Gene Tree for TPT1 (if available)
    TreeFam Gene Tree for TPT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPT1 gene
    1 SIMAP similar gene for TPT1 using alignment to 6 protein entries:     TCTP_HUMAN (see all proteins):
    TPT1P8

    Find genes that share paralogs with TPT1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TPT1 (see all 17)
    PGOHUM00000257781 PGOHUM00000258615 PGOHUM00000258122 PGOHUM00000239988 PGOHUM00000258137


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for TPT1    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407651071,2
    --45910968(+) GACTTC/TGCTCT 1 -- ds50010--------
    rs1128320191,2
    C--45911000(+) ACAAAC/G/TTTGCT 1 -- ds50011CSA 1
    rs770322391,2
    C,F--45911095(+) CCACAC/TTTCAG 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs30879891,2,4
    ----see VAR_0522732 mis40--------
    rs10624211,2
    ----45911100(-) AACATA/C/TTGAAG 1 -- ds5001 ese33MN NA 188
    rs342031931,2
    ----45910937(+) CAGGG-/AAGTTT 1 -- ds50010--------
    rs3766855741,2
    ----45911057(+) TAACTA/GTTCCG 1 -- ds50010--------
    rs3713032721,2
    ----45911014(+) ACTGAA/GTGAGT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TPT1 (45911008 - 45915505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TPT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510579CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TPT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600763    OMIM disorders: --

    1 disease for TPT1:    
    About MalaCards
    mycetoma

    2 diseases from the University of Copenhagen DISEASES database for TPT1:
    Urticaria     Hypersensitivity reaction type I disease

    Find genes that share disorders with TPT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TPT1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    urticaria chronic 76.3 4 8970437 (1), 17509061 (1), 19585861 (1), 16076300 (1)
    idiopathic urticaria 73.8 10 8970437 (5), 8842556 (2), 12877454 (1), 7687607 (1)
    urticaria 57.1 4 7600377 (1), 15725248 (1), 19585861 (1)
    asthma 50 27 7522854 (2), 1702128 (2), 19585861 (2), 8711735 (1) (see all 19)
    allergic rhinitis 45.4 3 1375820 (1), 7508179 (1), 7687607 (1)
    allergy 45.1 3 16491843 (1), 10200014 (1), 19484128 (1)
    allergic reaction 40.3 3 12487227 (2), 19484128 (1)
    allergy drug 40.1 2 12876410 (1), 17460952 (1)
    bronchial hyperreactivity 38.7 2 8814942 (1)
    tumors 37.1 99 15489264 (4), 10880768 (3), 18630514 (2), 9588028 (2) (see all 55)

    Genetic Association Database (GAD): TPT1
    Human Genome Epidemiology (HuGE) Navigator: TPT1 (3 documents)

    Export disorders for TPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPT1 gene, integrated from 10 sources (see all 256):
    (articles sorted by number of sources associating them with TPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence coding for a translationally controlled human tumor protein. (PubMed id 2813067)1, 2, 3 Gross B.... Bielka H. (Nucleic Acids Res. 1989)
    2. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PubMed id 15958728)1, 2, 9 Arcuri F.... Cintorino M. (Biol. Reprod. 2005)
    3. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PubMed id 15162379)1, 2, 9 Arcuri F.... del Vecchio M.T. (Prostate 2004)
    4. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PubMed id 12167714)1, 2, 9 Yarm F.R. (Mol. Cell. Biol. 2002)
    5. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PubMed id 9059837)1, 2, 9 Sanchez J.-C.... Hochstrasser D.F. (Electrophoresis 1997)
    6. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12--&gt;q14. (PubMed id 10343127)1, 3, 9 MacDonald S.M....Jabs E.W. (Cytogenet. Cell Genet. 1999)
    7. Molecular identification of an IgE-dependent histamine-releasing factor. (PubMed id 7542803)1, 2, 9 MacDonald S.M.... Lichtenstein L.M. (Science 1995)
    8. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (Cell. Microbiol. 2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    10. TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PubMed id 15319436)1, 2 Amzallag N.... Telerman A. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7178 HGNC: 12022 AceView: TPT1 Ensembl:ENSG00000133112 euGenes: HUgn7178
    ECgene: TPT1 H-InvDB: TPT1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TPT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TPT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPT1 gene:
    Search GeneIP for patents involving TPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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