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Aliases for TPT1 Gene

Aliases for TPT1 Gene

  • Tumor Protein, Translationally-Controlled 1 2 3 5
  • Histamine-Releasing Factor 3 4
  • Fortilin 3 4
  • TCTP 3 4
  • P23 3 4
  • HRF 3 4
  • Translationally-Controlled Tumor Protein 3
  • P02 3

External Ids for TPT1 Gene

Previous GeneCards Identifiers for TPT1 Gene

  • GC13M043911
  • GC13M039897
  • GC13M044847
  • GC13M043709
  • GC13M044810
  • GC13M044673
  • GC13M044815
  • GC13M044818
  • GC13M044821
  • GC13M044824
  • GC13M044827
  • GC13M044830
  • GC13M045912
  • GC13M045914
  • GC13M026712
  • GC13M045917
  • GC13M045921
  • GC13M045924
  • GC13M045937
  • GC13M045943
  • GC13M045955
  • GC13M045973

Summaries for TPT1 Gene

GeneCards Summary for TPT1 Gene

TPT1 (Tumor Protein, Translationally-Controlled 1) is a Protein Coding gene. Diseases associated with TPT1 include Urticaria and Allergic Hypersensitivity Disease. Among its related pathways are Ca, cAMP and Lipid Signaling and PLK1 signaling events. GO annotations related to this gene include poly(A) RNA binding and transcription factor binding.

UniProtKB/Swiss-Prot for TPT1 Gene

  • Involved in calcium binding and microtubule stabilization.

Gene Wiki entry for TPT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPT1 Gene

Genomics for TPT1 Gene

Regulatory Elements for TPT1 Gene

Enhancers for TPT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F045372 1.1 Ensembl ENCODE 12.5 -31.7 -31725 1.6 INSM2 FEZF1 ZNF2 ZNF391 ZNF202 ZNF362 ZNF280D OVOL3 ZEB2 TSHZ1 TPT1-AS1 SLC25A30 TPT1 SLC25A30-AS1 GC13P045378 GC13P045379 GC13P045380 PIR60049 ENSG00000228886
GH13F045370 1 Ensembl ENCODE 12.5 -29.9 -29870 0.9 CTCF TEAD4 RAD21 ZNF2 ZNF316 POLR2A EED ZNF143 SMC3 PRDM10 TPT1 TPT1-AS1 SLC25A30 GC13P045378 GC13P045379 GC13P045380 PIR60049 ENSG00000228886
GH13F044902 0.9 Ensembl ENCODE 7.9 +436.4 436379 5.6 RFX1 SIN3A RAD21 NR2F2 ZNF274 JUND GATA3 FOS TPT1 TPT1-AS1 RN7SL49P LOC105370187 TRE-TTC2-1
GH13F045366 1.5 FANTOM5 Ensembl ENCODE 2.2 -26.8 -26765 2.7 HDGF INSM2 KLF17 EGR1 ZNF366 SCRT2 ZNF143 RCOR1 FOS CREM SLC25A30 TPT1-AS1 COG3 TPT1 GC13P045378 GC13P045379 GC13P045380 PIR60049 ENSG00000228886
GH13F045204 1.5 FANTOM5 Ensembl ENCODE 2.1 +134.1 134081 5.4 INSM2 FEZF1 ZNF2 RAD21 ZNF335 GLIS2 SCRT2 ETV6 FOS CREM GTF2F2 KCTD4 TPT1 COG3 RNU6-69P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPT1 on UCSC Golden Path with GeneCards custom track

Promoters for TPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TPT1 Gene

45,333,471 bp from pter
45,341,370 bp from pter
7,900 bases
Minus strand

Genomic View for TPT1 Gene

Genes around TPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPT1 Gene

Proteins for TPT1 Gene

  • Protein details for TPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Translationally-controlled tumor protein
    Protein Accession:
    Secondary Accessions:
    • B2R7E5
    • Q6YLS2
    • Q7Z4J4
    • Q8TBK7
    • Q96EE2
    • Q9UC70

    Protein attributes for TPT1 Gene

    172 amino acids
    Molecular mass:
    19595 Da
    Quaternary structure:
    • Interacts with STEAP3.

    Three dimensional structures from OCA and Proteopedia for TPT1 Gene

    Alternative splice isoforms for TPT1 Gene


neXtProt entry for TPT1 Gene

Post-translational modifications for TPT1 Gene

  • Ubiquitination at Lys 102 and Lys 164
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TPT1 (TPT1)

No data available for DME Specific Peptides for TPT1 Gene

Domains & Families for TPT1 Gene

Suggested Antigen Peptide Sequences for TPT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TCTP domain.
  • Belongs to the TCTP family.
  • Contains 1 TCTP domain.
  • Belongs to the TCTP family.
genes like me logo Genes that share domains with TPT1: view

No data available for Gene Families for TPT1 Gene

Function for TPT1 Gene

Molecular function for TPT1 Gene

GENATLAS Biochemistry:
tumor protein,translationally controlled 1
UniProtKB/Swiss-Prot Function:
Involved in calcium binding and microtubule stabilization.
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection.

Gene Ontology (GO) - Molecular Function for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15162379
GO:0005515 protein binding IPI 16730713
GO:0008017 microtubule binding IBA --
GO:0008134 transcription factor binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TPT1: view
genes like me logo Genes that share phenotypes with TPT1: view

Animal Models for TPT1 Gene

MGI Knock Outs for TPT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPT1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPT1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPT1 Gene

Localization for TPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPT1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPT1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15319436
GO:0005634 nucleus IDA 11598139
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IDA,TAS 16130169
GO:0005771 multivesicular body IDA 15319436
genes like me logo Genes that share ontologies with TPT1: view

Pathways & Interactions for TPT1 Gene

genes like me logo Genes that share pathways with TPT1: view

Pathways by source for TPT1 Gene

4 Cell Signaling Technology pathways for TPT1 Gene
1 BioSystems pathway for TPT1 Gene

SIGNOR curated interactions for TPT1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IC 15958728
GO:0006874 cellular calcium ion homeostasis IC 15958728
GO:0009615 response to virus IEP 16548883
GO:0019827 stem cell population maintenance IEA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with TPT1: view

Drugs & Compounds for TPT1 Gene

(8) Drugs for TPT1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for TPT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPT1: view

Transcripts for TPT1 Gene

Unigene Clusters for TPT1 Gene

Tumor protein, translationally-controlled 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - -
SP7: -
SP8: - - - -
SP9: - -

Relevant External Links for TPT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for TPT1 Gene

This gene is overexpressed in Oral epithelium (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPT1 Gene

Protein tissue co-expression partners for TPT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPT1 Gene:


SOURCE GeneReport for Unigene cluster for TPT1 Gene:


mRNA Expression by UniProt/SwissProt for TPT1 Gene:

Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate.
genes like me logo Genes that share expression patterns with TPT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TPT1 Gene

Orthologs for TPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TPT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPT1 34 35
  • 99.81 (n)
(Ornithorhynchus anatinus)
Mammalia TPT1 35
  • 98 (a)
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
TPT1 34 35 35
  • 96.51 (n)
(Canis familiaris)
Mammalia TPT1 34 35
  • 95.74 (n)
(Rattus norvegicus)
Mammalia Tpt1 34
  • 90.7 (n)
(Mus musculus)
Mammalia Tpt1 34 16 35
  • 90.31 (n)
(Monodelphis domestica)
Mammalia TPT1 35
  • 80 (a)
(Gallus gallus)
Aves TPT1 34 35
  • 84.88 (n)
(Anolis carolinensis)
Reptilia TPT1 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpt1 34
  • 70.54 (n)
Str.17076 34
African clawed frog
(Xenopus laevis)
Amphibia tpt1-prov 34
(Danio rerio)
Actinopterygii tpt1 34 35
  • 68.23 (n)
tctp 34
fruit fly
(Drosophila melanogaster)
Insecta Tctp 34 35
  • 57.68 (n)
CG4800 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TCTP_ANOGA 34
  • 56.69 (n)
(Caenorhabditis elegans)
Secernentea tct-1 34 35
  • 51.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TMA19 34 35 37
  • 56.29 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12716g 34
  • 55.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR075C 34
  • 53.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TCTP 34
  • 51.61 (n)
(Oryza sativa)
Liliopsida Os11g0660500 34
  • 51.81 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F12.02c 34
  • 55.69 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06464 34
  • 54.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5297 35
  • 39 (a)
Species where no ortholog for TPT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPT1 Gene

Gene Tree for TPT1 (if available)
Gene Tree for TPT1 (if available)

Paralogs for TPT1 Gene

No data available for Paralogs for TPT1 Gene

Variants for TPT1 Gene

Sequence variations from dbSNP and Humsavar for TPT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1058093 -- 45,339,558(-) AAAAC(C/T)TTTTA upstream-variant-2KB, reference, missense
rs1062420 -- 45,337,036(-) AATAT(A/G)AAAAA downstream-variant-500B, utr-variant-3-prime
rs1062421 -- 45,336,965(-) AACAT(A/C/T)TGAAG utr-variant-3-prime
rs111635028 -- 45,340,187(+) CATCT(G/T)CATTA intron-variant, upstream-variant-2KB
rs112020474 -- 45,341,366(+) GCTCC(G/T)TTCCA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TPT1 Gene

Variant ID Type Subtype PubMed ID
nsv1046200 CNV gain 25217958
nsv477869 CNV novel sequence insertion 20440878
nsv510579 CNV deletion 20534489
nsv951078 CNV duplication 24416366
nsv977234 CNV duplication 23825009
nsv983582 CNV duplication 23825009

Variation tolerance for TPT1 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPT1 Gene

Disorders for TPT1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TPT1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic hypersensitivity disease
  • allergic disease
  • asthma, protection against
paraneoplastic cerebellar degeneration
  • madura foot
- elite association - COSMIC cancer census association via MalaCards
Search TPT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPT1 Gene

Publications for TPT1 Gene

  1. The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PMID: 15958728) Arcuri F. … Cintorino M. (Biol. Reprod. 2005) 3 4 22 64
  2. Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PMID: 15162379) Arcuri F. … del Vecchio M.T. (Prostate 2004) 3 4 22 64
  3. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PMID: 12167714) Yarm F.R. (Mol. Cell. Biol. 2002) 3 4 22 64
  4. Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PMID: 10343127) MacDonald S.M. … Jabs E.W. (Cytogenet. Cell Genet. 1999) 2 3 22 64
  5. Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PMID: 9059837) Sanchez J.-C. … Hochstrasser D.F. (Electrophoresis 1997) 3 4 22 64

Products for TPT1 Gene

  • Cloud-Clone Corp. Antibodies for TPT1
  • Cloud-Clone Corp. Proteins for TPT1
  • Cloud-Clone Corp Assay Kits for TPT1

Sources for TPT1 Gene

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