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TPT1 Gene

protein-coding GIFtS: 68

GC13M044830

tumor protein, translationally-controlled 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ27337 ^²
Fortilin ^³
HRF ^², ³, ⁵
OTTHUMP00000018344 ^²
TCTP ^¹, ², ³
fortilin ^¹, ²
p02 ^²
p23 ^³

Descriptions
Histamine-releasing factor ^², ³
tumor protein, translationally-controlled 1 ^²

External Ids
HGNC: 12022¹
Entrez Gene: 7178²
UniProtKB: P13693³
Ensembl: ENSG00000133112⁷

Search outside databases for aliases for TPT1 gene

Previous GC identifers: GC13M043911 GC13M039897 GC13M044847 GC13M043709 GC13M044810 GC13M044673 GC13M044815 GC13M044818 GC13M044821 GC13M044824 GC13M044827

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693

Function: Involved in calcium binding and microtubule stabilization

Gene Wiki entry for TPT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TPT1 gene

Entrez Gene cytogenetic band: 13q12-q14 Ensembl cytogenetic band: 13q14.12 HGNC cytogenetic band: 13q14

TPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M044830: (about GC identifiers)

Start:	44,809,008 bp from pter
End:	44,813,347 bp from pter
Size:	4,340 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693 (See protein sequence)

Recommended Name: Translationally-controlled tumor protein

Size: 172 amino acids; 19595 Da

Subunit: Interacts with STEAP3

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1YZ1 (3D)

2HR9 (3D)

Secondary accessions: Q6YLS2 Q7Z4J4 Q96EE2 Q9UC70

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003286.1

ENSEMBL proteins:

ENSP00000339051 ENSP00000368344 ENSP00000368350 ENSP00000368345

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TCTP)
	Human Recombinant Proteins from Abnova (TPT1)

OriGene Purified Recombinant Human Protein: TPT1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	15319436
GO:0005737	cytoplasm	TAS	16130169
GO:0005771	multivesicular body	IDA	15319436
GO:0045298	colocalizes with tubulin complex	IDA	15162379

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Antibodies for TPT1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TPT1
	R&D Systems Antibodies for TPT1 (TPT1/TCTP)
	Antibodies from Abcam (TCTP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TPT1)
	Novus Biologicals Antibodies for TPT1

Assays for TPT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P13693

ProtoNet protein and cluster: P13693

1 Blocks protein family: IPB001983 Translationally controlled tumor protein

UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693

Similarity: Belongs to the TCTP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TPT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC022436

Applied Biosystems Silencer® siRNAs for TPT1

Sigma-Aldrich siRNA for TPT1

Sigma-Aldrich shRNA for TPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TPT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003295
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003295
untagged cDNA clones in CMV expression vector (see all 3): BC022436

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003295

UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693

Function: Involved in calcium binding and microtubule stabilization

Genatlas biochemistry entry for TPT1:

tumor protein,translationally controlled 1

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tpt1):

cellular	embryogenesis	growth/size	lethality-prenatal/perinatal	life span-post-weaning/aging
normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IDA	15162379 15958728
GO:0005515	protein binding	IPI	18504434

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for TPT1

5/28 Interacting proteins for TPT1 (P13693^{1, 2} ENSP00000339051³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637², ENSP00000269305³	MINT-6785105 MINT-6785427 MINT-6785091 MINT-6785384 MINT-6785370 STRING (score=.768)
TSC22D1	Q15714², ENSP00000317053³	MINT-6173240 MINT-6173217 MINT-6173253 MINT-6173270 MINT-6173230 STRING (score=.734)
ATP1A1	P05023², ENSP00000295598³	MINT-2634433 STRING (score=.873)
CHFR	Q96EP1¹	EBI-1783169, EBI-718923
VHL	P40337¹	EBI-1783169, EBI-301246

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006816	calcium ion transport	IC	15958728
GO:0006874	cellular calcium ion homeostasis	IC	15958728
GO:0006916	anti-apoptosis	TAS	16130169
GO:0042981	regulation of apoptosis	NAS	15162379

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TPT1
6 Novoseek chemical compound relationships for TPT1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	52.62	2	1382479 (2)
fmlp	51.24	4	18322233 (1), 1702129 (1)
allergens	45.95	2	1878139 (1), 17024353 (1)
calcium	12.85	47	17705784 (7), 10477280 (5), 15958728 (5), 15162379 (4) (see all 7)
histidine	0.00	3	11985867 (2)
arachidonic acid	0.00	1	8324393 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TPT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC022436

Sigma-Aldrich siRNA for TPT1

Sigma-Aldrich shRNA for TPT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003295

REFSEQ mRNAs for TPT1 gene:

NM_003295.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003295

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003295
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003295
                                 untagged cDNA clones in CMV expression vector (see all 3): BC022436

Additional cDNA sequence:

AK130847.1 AK296587.1 AK296952.1 AK312951.1 AY117678.1 AY334563.1 AY952884.2 BC003352.2

BC012431.1 BC022436.1 BC040008.1 BC052333.1 CR457036.1 CR590628.1 CR591807.1 CR596782.1

CR600220.1 CR603315.1 CR606684.1 CR607344.1 CR609479.1 CR615436.1 CR617312.1 CR618209.1

CR619808.1 CR620037.1 CR623434.1 CR624492.1 CR624864.1 CR626086.1 CR626131.1 L13806.1

X16064.1 X64899.1

24/145 DOTS entries (see all 145 ):

DT.91781826 DT.100733394 DT.100733431 DT.100733370 DT.91781857 DT.100733383 DT.100733424 DT.100733358

DT.87018221 DT.91781818 DT.97869274 DT.91781854 DT.100733416 DT.120768188 DT.100733395 DT.120768288

DT.95371615 DT.100733363 DT.91679216 DT.100875372 DT.100733356 DT.120768190 DT.120768345 DT.100733380

24/4717 AceView cDNA sequences (see all 4717 ):

BE773374 AA384881 CB111802 BG032149 CB110614 BM790901 CA950607 BM558218

BM772601 BM768449 BM686214 BG402975 BU507430 BQ788018 CA412757 BM831639

BM784550 CB164588 BU581521 BM994614 BQ948938 BE811663 BF037351 AI751451

highest scoring ESTs for TPT1:

X16064 AA082090 AA091100 AA176676 AA249276 AA307370 AA308528 AA315877 AA316712 AA320747

Unigene Cluster for TPT1:

Tumor protein, translationally-controlled 1

Hs.374596 [show with all ESTs]

Unigene Representative Sequence: BG033621

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TPT1 (see all 9 )

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:			-				-		-						-		-										-
SP2:							-		-						-		-
SP3:															-		-
SP4:			-				-		-
SP5:			-				-

About this scheme

ECgene alternative splicing isoforms for TPT1

4 Ensembl transcripts including schematic representations:

ENST00000309246 ENST00000379055 ENST00000379060 ENST00000379056

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TPT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TPT1

¹ / ² / ³

13 probe-sets matching TPT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31584_at²^{, 3}	U95-A	12	1.00	0.30	1.00	1.00	X16064	1.00	0.90	0.95	1
214327_x_at²^{, 3}	U133-A	6	1.00	0.60	--	--	AI888178	0.40	0.67	0.55	1
216520_s_at²	U133-A	9	1.00	0.42	--	--	--	--	--	--	--
212284_x_at²^{, 3}	U133-A	6	1.00	0.41	--	--	BG498776	0.20	1.00	0.72	1
211943_x_at²^{, 3}	U133-A	8	1.00	0.37	--	--	AL565449	0.20	0.33	0.27	1
212869_x_at²^{, 3}	U133-A	9	1.00	0.36	--	--	AI721229	0.80	0.88	0.84	1
207783_x_at²	U133-A	5	0.55	0.23	--	--	--	--	--	--	--
214327_x_at²	U133Plus2	6	1.00	0.60	--	--	--	--	--	--	--
216520_s_at²	U133Plus2	9	1.00	0.42	--	--	--	--	--	--	--
212284_x_at²	U133Plus2	6	1.00	0.41	--	--	--	--	--	--	--
211943_x_at²	U133Plus2	8	1.00	0.37	--	--	--	--	--	--	--
212869_x_at²	U133Plus2	9	1.00	0.36	--	--	--	--	--	--	--
207783_x_at²	U133Plus2	5	0.55	0.23	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAGGTTGTCT

SOURCE GeneReport for Unigene cluster: Hs.374596
Expression variation in blood from EXPOLDB for TPT1
UniProtKB/Swiss-Prot: TCTP_HUMAN, P13693
Tissue specificity: Found in several healthy and tumoral cells including erythrocytes, hepatocytes,
macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas,
and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in
placenta and prostate

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TPT1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TPT1¹	--	tumor protein, translationally-controlled 1	95.74(n) 100(a)	476924 XM_534126.2 XP_534126.1
chimpanzee (Pan troglodytes)	TPT1¹	--	tumor protein, translationally-controlled 1	100(n) 100(a)	452575 XM_001154834.1 XP_001154834.1
cow (Bos taurus)	TPT1¹	--	tumor protein, translationally-controlled 1	95.35(n) 97.09(a)	788457 XM_001254326.1 XP_001254327.1
rat (Rattus norvegicus)	Tpt1¹	--	tumor protein, translationally-controlled 1	90.7(n) 95.93(a)	116646 NM_053867.1 NP_446319.1
mouse (Mus musculus)	Tpt1⁵ EG627798¹	14 (43.00 cM)⁵	tumor protein, translationally-controlled 1⁵ predicted gene, EG627798¹	88.57(n)¹ 92.44(a)¹	627798¹ XM_892497.2¹ XP_897590.1¹ AK149695⁵ AK150300⁵ (see all 29)

About this table Species with no ortholog for TPT1

ENSEMBL Gene Tree for TPT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Pseudogenes

12 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/76 NCBI SNPs in TPT1 are shown (see all 76 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 57)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2234211^1,2	C,F,H,O	44814016(-)	`TCCCGT/CGACAT`	1	--	ng3¹		16	EU EA WA NA	1466
	rs2234227^1,2	A,C,F,H	44809482(-)	`TCATCA/CTAACT`	1	--	ut3¹		8	EU EA WA	830
	rs2234212^1,2	A,C,F,H	44813977(-)	`AGACCT/CTGCGC`	1	--	ng3¹		4	EU EA WA	410
	rs1062420^1,2	C,F,H	44809171(-)	`AATATA/GAAAAA`	1	--	ng5¹		4	EU EA WA	420
	rs2234213^1,2	F,H	44813851(-)	`ATGCTG/TAAAAG`	1	--	ng3¹		4	EU EA WA	402
	rs12863264^1,2	F,H	44815174(+)	`AAAAGA/TTGGGG`	1	--	ng3¹ trp³		4	EU EA WA	360
	rs12872310^1,2	F,H	44813481(+)	`ACTTGA/CGGCGG`	1	--	ng3¹ ese³		5	MN EA EU	1514
	rs3087989^1,2	F	44810875(+)	`AGCAAC/ACATGC`	1	F/V	mis¹ ese³		1	MN	184
--	rs11552492^1,2	H	44812231(-)	`CGAAAG/TCACAG`	1	S/I	mis¹ ese³		4	EU EA WA	406
--	rs12872567^1,2	F	44813500(+)	`GGCTCC/TGTTCC`	1	--	ng3¹		2	MN EA	1252

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HapMap Linkage Disequilibrium images for TPT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600763

10/24 Novoseek disease relationships for TPT1 gene (see all 24 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
urticaria chronic	76.28	3	8970437 (1), 17509061 (1), 16076300 (1)
idiopathic urticaria	75.16	10	8970437 (5), 8842556 (2), 12877454 (1), 7687607 (1)
urticaria	56.73	3	7600377 (1), 15725248 (1)
asthma	50.21	25	7522854 (2), 1702128 (2), 8711735 (1), 7581067 (1) (see all 18)
allergic rhinitis	47.67	3	1375820 (1), 7508179 (1), 7687607 (1)
allergy	45.49	2	16491843 (1), 10200014 (1)
allergy drug	42.18	2	12876410 (1), 17460952 (1)
bronchial hyperreactivity	40.00	2	8814942 (1)
allergic reaction	35.88	2	12487227 (2)
tumors	33.10	85	15489264 (4), 10880768 (3), 18630514 (2), 9588028 (2) (see all 45)

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Human Genome Epidemiology Navigator: TPT1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/169 PubMed articles for TPT1 gene (see all 169 ):

cDNA sequence coding for a translationally controlled human tumor protein. (PubMed id 2813067)^{2, 3, 4} Gross B.... Bielka H. (1989)
The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells. (PubMed id 15958728)^{1, 3, 4} Arcuri F.... Cintorino M. (2005)
Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity. (PubMed id 15162379)^{1, 3, 4} Arcuri F.... del Vecchio M.T. (2004)
Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. (PubMed id 12167714)^{1, 3, 4} Yarm F.R. (2002)
Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes. (PubMed id 9059837)^{1, 3, 4} Sanchez J.-C.... Hochstrasser D.F. (1997)
Chromosomal localization of tumor protein, translationally-controlled 1 (TPT1) encoding the human histamine releasing factor (HRF) to 13q12-->q14. (PubMed id 10343127)^{1, 2, 3} MacDonald S.M....Jabs E.W. (1999)
Molecular identification of an IgE-dependent histamine-releasing factor. (PubMed id 7542803)^{1, 3, 4} MacDonald S.M.... Lichtenstein L.M. (1995)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. (PubMed id 15319436)^{3, 4} Amzallag N.... Telerman A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7178	HGNC: 12022	AceView: TPT1	Ensembl:ENSG00000133112	euGenes: HUgn7178
ECgene: TPT1	H-InvDB: TPT1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TPT1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TPT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TPT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TPT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TPT1		Antibodies for TPT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TPT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
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Antibodies for TPT1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TPT1 Gene at Home site.
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TPT1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for TPT1

Summaries
for TPT1

Genomic Location
for TPT1

Proteins
for TPT1

Protein Domains/
Families
for TPT1

Gene Function
for TPT1

Pathways & Interactions
for TPT1

Drugs & Compounds
for TPT1

Transcripts
for TPT1

Expression
for TPT1

Orthologs
for TPT1

Paralogs
for TPT1

SNPs/Variants
for TPT1

Disorders & Mutations
for TPT1

Medical News
for TPT1

Publications
for TPT1

Search for TPT1

Genome Databases showing TPT1

Other Databases showing TPT1

Specialized Databases showing TPT1

Licensable Technologies
for TPT1

Services
for TPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TPT1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor TPT1

Summariesfor TPT1

Genomic Locationfor TPT1

Proteinsfor TPT1

Protein Domains/Familiesfor TPT1

Gene Functionfor TPT1

Pathways & Interactionsfor TPT1

Drugs & Compoundsfor TPT1

Transcriptsfor TPT1

Expression for TPT1

Orthologsfor TPT1

Paralogsfor TPT1

SNPs/Variantsfor TPT1

Disorders & Mutationsfor TPT1

Medical Newsfor TPT1

Publicationsfor TPT1

Search for TPT1

Genome Databases showing TPT1

Other Databases showing TPT1

Specialized Databases showing TPT1

Licensable Technologiesfor TPT1

Servicesfor TPT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TPT1

Summaries
for TPT1

Genomic Location
for TPT1

Proteins
for TPT1

Protein Domains/
Families
for TPT1

Gene Function
for TPT1

Pathways & Interactions
for TPT1

Drugs & Compounds
for TPT1

Transcripts
for TPT1

Expression
for TPT1

Orthologs
for TPT1

Paralogs
for TPT1

SNPs/Variants
for TPT1

Disorders & Mutations
for TPT1

Medical News
for TPT1

Publications
for TPT1

Licensable Technologies
for TPT1

Services
for TPT1