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Aliases for TPST2 Gene

Aliases for TPST2 Gene

  • Tyrosylprotein Sulfotransferase 2 2 3 4
  • EC 2.8.2.20 4 63
  • TPST-2 3 4
  • Transport And Golgi Organization 13 Homolog B (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog B 3
  • Protein-Tyrosine Sulfotransferase 2 3
  • Tyrosylprotein Phosphotransferase 2 3
  • Tyrosylprotein Sulfotransferase-2 3
  • TANGO13B 3

External Ids for TPST2 Gene

Previous GeneCards Identifiers for TPST2 Gene

  • GC22M023617
  • GC22M025246
  • GC22M025238
  • GC22M026921
  • GC22M009869

Summaries for TPST2 Gene

Entrez Gene Summary for TPST2 Gene

  • The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPST2 Gene

TPST2 (Tyrosylprotein Sulfotransferase 2) is a Protein Coding gene. GO annotations related to this gene include protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST1.

UniProtKB/Swiss-Prot for TPST2 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST2 Gene

Genomics for TPST2 Gene

Regulatory Elements for TPST2 Gene

Genomic Location for TPST2 Gene

Start:
26,525,492 bp from pter
End:
26,596,717 bp from pter
Size:
71,226 bases
Orientation:
Minus strand

Genomic View for TPST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST2 Gene

Proteins for TPST2 Gene

  • Protein details for TPST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60704-TPST2_HUMAN
    Recommended name:
    Protein-tyrosine sulfotransferase 2
    Protein Accession:
    O60704
    Secondary Accessions:
    • B3KQA7
    • Q6FI98
    • Q9H0V4

    Protein attributes for TPST2 Gene

    Size:
    377 amino acids
    Molecular mass:
    41912 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft

    Three dimensional structures from OCA and Proteopedia for TPST2 Gene

neXtProt entry for TPST2 Gene

Proteomics data for TPST2 Gene at MOPED

Post-translational modifications for TPST2 Gene

  • Glycosylation at Ser278, Ser285, Thr286, Asn343, and Asn368
  • Modification sites at PhosphoSitePlus

Domains for TPST2 Gene

Gene Families for TPST2 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for TPST2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60704

UniProtKB/Swiss-Prot:

TPST2_HUMAN :
  • O60704
Family:
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST2: view

Function for TPST2 Gene

Molecular function for TPST2 Gene

GENATLAS Biochemistry: tyrosylprotein sulfotransferase 2,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate
UniProtKB/Swiss-Prot Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

Enzyme Numbers (IUBMB) for TPST2 Gene

Gene Ontology (GO) - Molecular Function for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0008476 protein-tyrosine sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with TPST2: view
genes like me logo Genes that share phenotypes with TPST2: view

Animal Models for TPST2 Gene

MGI Knock Outs for TPST2:

miRNA for TPST2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for TPST2 Gene

Localization for TPST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPST2 Gene COMPARTMENTS Subcellular localization image for TPST2 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane TAS 9736702
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPST2: view

Pathways for TPST2 Gene

SuperPathways for TPST2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IEA --
GO:0007342 fusion of sperm to egg plasma membrane IEA --
GO:0060468 prevention of polyspermy IEA --
genes like me logo Genes that share ontologies with TPST2: view

No data available for Pathways by source for TPST2 Gene

Compounds for TPST2 Gene

(2) HMDB Compounds for TPST2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(2) Novoseek inferred chemical compound relationships for TPST2 Gene

Compound -log(P) Hits PubMed IDs
tpst 98.5 5
tyrosine 46.5 1
genes like me logo Genes that share compounds with TPST2: view

Transcripts for TPST2 Gene

Unigene Clusters for TPST2 Gene

Tyrosylprotein sulfotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -

Relevant External Links for TPST2 Gene

GeneLoc Exon Structure for
TPST2
ECgene alternative splicing isoforms for
TPST2

Expression for TPST2 Gene

mRNA expression in normal human tissues for TPST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPST2 Gene

This gene is overexpressed in Pancreas (12.3) and Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPST2 Gene

SOURCE GeneReport for Unigene cluster for TPST2 Gene Hs.632768

mRNA Expression by UniProt/SwissProt for TPST2 Gene

O60704-TPST2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TPST2: view

Orthologs for TPST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPST2 35
  • 99.29 (n)
  • 99.73 (a)
TPST2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPST2 35
  • 91.16 (n)
  • 93.63 (a)
TPST2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPST2 35
  • 92.22 (n)
  • 94.69 (a)
TPST2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpst2 35
  • 89.01 (n)
  • 94.68 (a)
Tpst2 16
Tpst2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPST2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPST2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpst2 35
  • 88.39 (n)
  • 94.15 (a)
chicken
(Gallus gallus)
Aves TPST2 35
  • 77.72 (n)
  • 83.02 (a)
TPST2 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25665 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19735 35
tpst2 35
  • 66.67 (n)
  • 76.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8743 35
zebrafish
(Danio rerio)
Actinopterygii tpst2 35
  • 65 (n)
  • 65.78 (a)
tpst2 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tango13 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tpst-1 36
  • 51 (a)
ManyToMany
tpst-2 36
  • 40 (a)
ManyToMany
Y111B2A.15 37
  • 63 (a)
F42G9.8 37
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for TPST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST2 Gene

ENSEMBL:
Gene Tree for TPST2 (if available)
TreeFam:
Gene Tree for TPST2 (if available)

Paralogs for TPST2 Gene

Paralogs for TPST2 Gene

Selected SIMAP similar genes for TPST2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TPST2 Gene

genes like me logo Genes that share paralogs with TPST2: view

Variants for TPST2 Gene

Sequence variations from dbSNP and Humsavar for TPST2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4275 -- 26,525,759(+) AAAGT(A/G)AGGCA utr-variant-3-prime
rs4370 -- 26,547,679(+) agggg(A/G)tggtg intron-variant, upstream-variant-2KB
rs732932 -- 26,544,026(+) ATCCT(C/T)GCAGT intron-variant
rs732933 -- 26,543,815(+) AGCAA(C/T)GACCT intron-variant
rs763088 -- 26,567,473(+) AAAAG(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv1397e1 CNV Complex 17122850
nsv914954 CNV Loss 21882294
nsv914955 CNV Loss 21882294
esv2724093 CNV Deletion 23290073

Relevant External Links for TPST2 Gene

HapMap Linkage Disequilibrium report
TPST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST2 Gene

Disorders for TPST2 Gene

Relevant External Links for TPST2

Genetic Association Database (GAD)
TPST2
Human Genome Epidemiology (HuGE) Navigator
TPST2
genes like me logo Genes that share disorders with TPST2: view

No data available for UniProtKB/Swiss-Prot for TPST2 Gene

Publications for TPST2 Gene

  1. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang Y.-B. … Moore K.L. (J. Biol. Chem. 1998) 2 3 4 23
  2. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. (PMID: 9736702) Beisswanger R. … Huttner W.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23
  3. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PMID: 12169668) Seibert C. … Sakmar T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  4. Pattern and temporal sequence of sulfation of CCR5 N-terminal peptides by tyrosylprotein sulfotransferase-2: an assessment of the effects of N-terminal residues. (PMID: 19402700) Jen C.H. … Leary J.A. (Biochemistry 2009) 3 23
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4

Products for TPST2 Gene

  • Addgene plasmids for TPST2

Sources for TPST2 Gene

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