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Aliases for TPST2 Gene

Aliases for TPST2 Gene

  • Tyrosylprotein Sulfotransferase 2 2 3 4 5
  • EC 2.8.2.20 4 63
  • TPST-2 3 4
  • Transport And Golgi Organization 13 Homolog B (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog B 3
  • Protein-Tyrosine Sulfotransferase 2 2
  • Tyrosylprotein Phosphotransferase 2 3
  • Tyrosylprotein Sulfotransferase-2 3
  • TANGO13B 3

External Ids for TPST2 Gene

Previous GeneCards Identifiers for TPST2 Gene

  • GC22M023617
  • GC22M025246
  • GC22M025238
  • GC22M026921
  • GC22M009869

Summaries for TPST2 Gene

Entrez Gene Summary for TPST2 Gene

  • The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPST2 Gene

TPST2 (Tyrosylprotein Sulfotransferase 2) is a Protein Coding gene. GO annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST1.

UniProtKB/Swiss-Prot for TPST2 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST2 Gene

Genomics for TPST2 Gene

Regulatory Elements for TPST2 Gene

Genomic Location for TPST2 Gene

Chromosome:
22
Start:
26,521,983 bp from pter
End:
26,596,717 bp from pter
Size:
74,735 bases
Orientation:
Minus strand

Genomic View for TPST2 Gene

Genes around TPST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST2 Gene

Proteins for TPST2 Gene

  • Protein details for TPST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60704-TPST2_HUMAN
    Recommended name:
    Protein-tyrosine sulfotransferase 2
    Protein Accession:
    O60704
    Secondary Accessions:
    • B3KQA7
    • Q6FI98
    • Q9H0V4

    Protein attributes for TPST2 Gene

    Size:
    377 amino acids
    Molecular mass:
    41912 Da
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding cleft.

    Three dimensional structures from OCA and Proteopedia for TPST2 Gene

neXtProt entry for TPST2 Gene

Proteomics data for TPST2 Gene at MOPED

Post-translational modifications for TPST2 Gene

  • Glycosylation at Ser 278, Ser 285, Thr 286, Asn 343, and Asn 368
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TPST2 (Tyrosylprotein Sulfotransferase 2/TPST2)

Domains & Families for TPST2 Gene

Gene Families for TPST2 Gene

Protein Domains for TPST2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60704

UniProtKB/Swiss-Prot:

TPST2_HUMAN :
  • Belongs to the protein sulfotransferase family.
Family:
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST2: view

Function for TPST2 Gene

Molecular function for TPST2 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 2,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Enzyme Numbers (IUBMB) for TPST2 Gene

genes like me logo Genes that share phenotypes with TPST2: view

Animal Models for TPST2 Gene

MGI Knock Outs for TPST2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPST2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST2 Gene

Localization for TPST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPST2 Gene COMPARTMENTS Subcellular localization image for TPST2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TPST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane TAS 9736702
genes like me logo Genes that share ontologies with TPST2: view

Pathways & Interactions for TPST2 Gene

SuperPathways for TPST2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPST2 Gene

Drugs & Compounds for TPST2 Gene

(1) Drugs for TPST2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TPST2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with TPST2: view

Transcripts for TPST2 Gene

Unigene Clusters for TPST2 Gene

Tyrosylprotein sulfotransferase 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -

Relevant External Links for TPST2 Gene

GeneLoc Exon Structure for
TPST2
ECgene alternative splicing isoforms for
TPST2

Expression for TPST2 Gene

mRNA expression in normal human tissues for TPST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPST2 Gene

This gene is overexpressed in Pancreas (x12.3) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for TPST2 Gene

This gene is overexpressed in Pancreas (41.0) and Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPST2 Gene



SOURCE GeneReport for Unigene cluster for TPST2 Gene Hs.632768

mRNA Expression by UniProt/SwissProt for TPST2 Gene

O60704-TPST2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TPST2: view

Protein tissue co-expression partners for TPST2 Gene

Primer Products

In Situ Assay Products

Orthologs for TPST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPST2 35
  • 91.16 (n)
  • 93.63 (a)
TPST2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPST2 35
  • 92.22 (n)
  • 94.69 (a)
TPST2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpst2 35
  • 89.01 (n)
  • 94.68 (a)
Tpst2 16
Tpst2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPST2 35
  • 99.29 (n)
  • 99.73 (a)
TPST2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpst2 35
  • 88.39 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia TPST2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPST2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPST2 35
  • 77.72 (n)
  • 83.02 (a)
TPST2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19735 35
tpst2 35
  • 66.67 (n)
  • 76.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25665 35
zebrafish
(Danio rerio)
Actinopterygii tpst2 35
  • 65 (n)
  • 65.78 (a)
tpst2 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8743 35
fruit fly
(Drosophila melanogaster)
Insecta Tango13 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F42G9.8 37
  • 41 (a)
Y111B2A.15 37
  • 63 (a)
tpst-1 36
  • 51 (a)
ManyToMany
tpst-2 36
  • 40 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
Species with no ortholog for TPST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST2 Gene

ENSEMBL:
Gene Tree for TPST2 (if available)
TreeFam:
Gene Tree for TPST2 (if available)

Paralogs for TPST2 Gene

Paralogs for TPST2 Gene

(1) SIMAP similar genes for TPST2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TPST2 Gene

genes like me logo Genes that share paralogs with TPST2: view

Variants for TPST2 Gene

Sequence variations from dbSNP and Humsavar for TPST2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs4275 -- 26,525,759(+) AAAGT(A/G)AGGCA utr-variant-3-prime
rs4370 -- 26,547,679(+) agggg(A/G)tggtg intron-variant
rs1007876 -- 26,545,257(+) tgatg(A/G)tccca intron-variant
rs1007877 -- 26,545,294(+) caaga(C/G)gaaga intron-variant
rs763088 -- 26,567,473(+) AAAAG(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST2 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv1397e1 CNV Complex 17122850
nsv914954 CNV Loss 21882294
nsv914955 CNV Loss 21882294
esv2724093 CNV Deletion 23290073

Variation tolerance for TPST2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPST2 Gene

HapMap Linkage Disequilibrium report
TPST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST2 Gene

Disorders for TPST2 Gene

Relevant External Links for TPST2

Genetic Association Database (GAD)
TPST2
Human Genome Epidemiology (HuGE) Navigator
TPST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPST2

No disorders were found for TPST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPST2 Gene

Publications for TPST2 Gene

  1. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. (PMID: 9736702) Beisswanger R. … Huttner W.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 23 67
  2. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang Y.-B. … Moore K.L. (J. Biol. Chem. 1998) 2 3 23
  3. Pattern and temporal sequence of sulfation of CCR5 N-terminal peptides by tyrosylprotein sulfotransferase-2: an assessment of the effects of N-terminal residues. (PMID: 19402700) Jen C.H. … Leary J.A. (Biochemistry 2009) 3 23
  4. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PMID: 12169668) Seibert C. … Sakmar T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. Computational Evidence for the Catalytic Mechanism of Tyrosylprotein Sulfotransferases: A Density Functional Theory Investigation. (PMID: 26108987) Marforio T.D. … Calvaresi M. (Biochemistry 2015) 3

Products for TPST2 Gene

Sources for TPST2 Gene

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