Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TPST2 Gene

protein-coding   GIFtS: 59
GCID: GC22M026921

Tyrosylprotein Sulfotransferase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tyrosylprotein Sulfotransferase 21 2 3     Protein-Tyrosine Sulfotransferase 22
TPST-22 3     Transport And Golgi Organization 13 Homolog B2
EC 2.8.2.203 8     Tyrosylprotein Phosphotransferase 22
Transport And Golgi Organization 13 Homolog B (Drosophila)1     Tyrosylprotein Sulfotransferase-22
TANGO13B2     

External Ids:    HGNC: 120211   Entrez Gene: 84592   Ensembl: ENSG000001282947   OMIM: 6031265   UniProtKB: O607043   

Export aliases for TPST2 gene to outside databases

Previous GC identifers: GC22M023617 GC22M025246 GC22M025238 GC22M009869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TPST2 Gene:
The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins.
The encoded protein is a type II integral membrane protein found in the Golgi body. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPST2 Gene:
TPST2 (tyrosylprotein sulfotransferase 2) is a protein-coding gene. Diseases associated with TPST2 include atherosclerosis, and tonsillitis. GO annotations related to this gene include protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST1.

UniProtKB/Swiss-Prot: TPST2_HUMAN, O60704
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPST2 gene promoter:
         NCX/Ncx   HNF-1A   FAC1   POU2F1   HNF-1   POU2F1a   POU2F1b   FOXO4   POU2F1c   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TPST2 promoter sequence
   Search Chromatin IP Primers for TPST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

TPST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPST2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M026921:  view genomic region     (about GC identifiers)

Start:
26,921,458 bp from pter      End:
26,992,681 bp from pter
Size:
71,224 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TPST2_HUMAN, O60704 (See protein sequence)
Recommended Name: Protein-tyrosine sulfotransferase 2  
Size: 377 amino acids; 41912 Da
Subunit: Homodimer
Miscellaneous: Substrate peptides must be flexible in order to adopt an L-shaped conformation in the deep binding
cleft
3 PDB 3D structures from and Proteopedia for TPST2:
3AP1 (3D)        3AP2 (3D)        3AP3 (3D)    
Secondary accessions: B3KQA7 Q6FI98 Q9H0V4

Explore the universe of human proteins at neXtProt for TPST2: NX_O60704

Explore proteomics data for TPST2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser278, Ser285, Thr286, Asn343, Asn368
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TPST2 (O60704) (see all 15)
     MVRDGRA  LCNKDPF  ANPPNYG  YLSRLFPN 


    See TPST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008566.1  NP_003586.3  

    ENSEMBL proteins: 
     ENSP00000339813   ENSP00000381180   ENSP00000385192   ENSP00000403758   ENSP00000403875  
     ENSP00000400357   ENSP00000416791   ENSP00000401134   ENSP00000414809  

    TPST2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TPST2 (Tyrosylprotein Sulfotransferase 2/TPST2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TPST2
    OriGene Protein Over-expression Lysate for TPST2
    OriGene MassSpec for TPST2
    OriGene Custom Protein Services for TPST2
    GenScript Custom Purified and Recombinant Proteins Services for TPST2
    Novus Biologicals TPST2 Protein
    Novus Biologicals TPST2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TPST2
    Cloud-Clone Corp. Proteins for TPST2

    TPST2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for TPST2 (Tyrosylprotein Sulfotransferase 2/TPST2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TPST2
    Novus Biologicals TPST2 Antibodies
    Abcam antibodies for TPST2
    Cloud-Clone Corp. Antibodies for TPST2
    ThermoFisher Antibodies for TPST2
    LSBio Antibodies in human, mouse, rat for TPST2

    TPST2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TPST2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TPST2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TPST2
    Cloud-Clone Corp. CLIAs for TPST2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR026634 TPST

    Graphical View of Domain Structure for InterPro Entry O60704

    ProtoNet protein and cluster: O60704

    UniProtKB/Swiss-Prot: TPST2_HUMAN, O60704
    Similarity: Belongs to the protein sulfotransferase family


    TPST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPST2_HUMAN, O60704
    Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides
    Catalytic activity: 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein
    tyrosine-O-sulfate

         Genatlas biochemistry entry for TPST2:
    tyrosylprotein sulfotransferase 2,54/50kDa,catalyzing tyrosine o-sulfatin of proteins

         Enzyme Number (IUBMB): EC 2.8.2.201 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0008476protein-tyrosine sulfotransferase activity IEA--
         
    TPST2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tpst2):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  nervous system  reproductive system 

    TPST2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tpst2tm1Klm for TPST2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPST2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPST2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TPST2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TPST2

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPST2:
    hsa-mir-484 (MIRT042125), hsa-mir-615-3p (MIRT039710), hsa-mir-124-3p (MIRT022368), hsa-mir-98-5p (MIRT027431)

    Block miRNA regulation of human, mouse, rat TPST2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TPST2:
    hsa-miR-942 hsa-miR-656 hsa-miR-875-3p hsa-miR-376a* hsa-miR-526b hsa-miR-3942-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPST2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TPST2
    Predesigned siRNA for gene silencing in human, mouse, rat TPST2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TPST2

    Clone
    Products:
         
    OriGene clones in human, mouse for TPST2 (see all 13)
    OriGene ORF clones in mouse, rat for TPST2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TPST2 (NM_001008566)
    Sino Biological Human cDNA Clone for TPST2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TPST2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TPST2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TPST2_HUMAN, O60704: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum4
    extracellular1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0016020membrane TAS9736702
    GO:0016021integral component of membrane IEA--

    TPST2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPST2
    Interactions:

        Search GeneGlobe Interaction Network for TPST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TPST2 (O607043 ENSP000003398134) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
    CMKLR1Q997883, ENSP000003117334I2D: score=1 STRING: ENSP00000311733
    GPR1P460913I2D: score=1 
    CCR2ENSP000002923014STRING: ENSP00000292301
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006478peptidyl-tyrosine sulfation IEA--
    GO:0007342fusion of sperm to egg plasma membrane IEA--
    GO:0060468prevention of polyspermy IEA--

    TPST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPST2

    2 HMDB Compounds for TPST2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    2 Novoseek inferred chemical compound relationships for TPST2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tpst 98.5 6 9736702 (3), 9733778 (1), 19679829 (1)
    tyrosine 46.5 1 19658209 (1)



    TPST2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TPST2 gene (2 alternative transcripts): 
    NM_001008566.1  NM_003595.3  

    Unigene Cluster for TPST2:

    Tyrosylprotein sulfotransferase 2
    Hs.632768  [show with all ESTs]
    Unigene Representative Sequence: AK057171
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338754(uc003acx.3) ENST00000398110(uc003acw.3) ENST00000403880(uc011akf.1)
    ENST00000445720 ENST00000442495 ENST00000454778 ENST00000440953 ENST00000453117
    ENST00000450022
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TPST2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TPST2:
    hsa-miR-942 hsa-miR-656 hsa-miR-875-3p hsa-miR-376a* hsa-miR-526b hsa-miR-3942-5p hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPST2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TPST2
    Predesigned siRNA for gene silencing in human, mouse, rat TPST2
    Clone
    Products:
         
    OriGene clones in human, mouse for TPST2 (see all 13)
    OriGene ORF clones in mouse, rat for TPST2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TPST2 (NM_001008566)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TPST2
    OriGene qSTAR qPCR primer pairs in human, mouse for TPST2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPST2
      QuantiTect SYBR Green Assays in human, mouse, rat TPST2
      QuantiFast Probe-based Assays in human, mouse, rat TPST2

    Additional mRNA sequence: 

    AF049891.1 AF061254.1 AJ006198.1 AK057171.1 AK074538.1 AK075139.1 AK304545.1 AL136623.2 
    BC001057.2 BC017509.1 CR456597.1 CR533528.1 

    18 DOTS entries:

    DT.95074536  DT.100879535  DT.120672519  DT.95203993  DT.100879534  DT.95074529  DT.100715736  DT.95074531 
    DT.100879536  DT.120672555  DT.75107105  DT.100709256  DT.100833797  DT.427640  DT.75117263  DT.91817350 
    DT.97817555  DT.120672556 

    Selected AceView cDNA sequences (see all 263):

    AI338643 BU584161 F02698 H55336 Z43247 AA934634 CR595821 AI539184 
    AA397904 F02797 CR626262 CA423175 F05219 BM765809 F01475 CR596364 
    AI240941 BQ184023 F05892 CR595650 CR593537 CB113151 AW959870 CB107402 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPST2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -           -                                                         
    SP2:        -     -     -           -                                                         
    SP3:        -     -                 -                                                         
    SP4:        -     -     -                                                                     
    SP5:              -     -     -     -                                                         


    ECgene alternative splicing isoforms for TPST2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TPST2 expression in normal human tissues (normalized intensities)      TPST2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCTCAGC
    TPST2 Expression
    About this image


    TPST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TPST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPST2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632768

    UniProtKB/Swiss-Prot: TPST2_HUMAN, O60704
    Tissue specificity: Widely expressed

        Custom PCR Arrays for TPST2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TPST2
    OriGene qSTAR qPCR primer pairs in human, mouse for TPST2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPST2
    QuantiTect SYBR Green Assays in human, mouse, rat TPST2
    QuantiFast Probe-based Assays in human, mouse, rat TPST2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TPST2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpst21 , 5 protein-tyrosine sulfotransferase 21, 5 89.01(n)1
    94.68(a)1
      5 (54.65 cM)5
    220221  NM_009419.31  NP_033445.21 
     1122766915 
    chicken
    (Gallus gallus)
    Aves TPST21 tyrosylprotein sulfotransferase 2 77.72(n)
    83.02(a)
      416910  NM_001012794.1  NP_001012812.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256652 Xenopus laevis transcribed sequence with moderate similarity more 72.79(n)    CA789607.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tpst21 tyrosylprotein sulfotransferase 2 65(n)
    65.78(a)
      393391  NM_200419.1  NP_956713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango136
    Transport and Golgi organization 13
    41(a)
    1 → many
    X(13457856-13487257)
    worm
    (Caenorhabditis elegans)
    Secernentea Y111B2A.153 protein-tyrosine sulphotransferase 63(a)
    (best of 2)
      III(12724206-12733848)   --


    ENSEMBL Gene Tree for TPST2 (if available)
    TreeFam Gene Tree for TPST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TPST2 gene
    TPST12  
    1 SIMAP similar gene for TPST2 using alignment to 7 protein entries:     TPST2_HUMAN (see all proteins):
    TPST1

    TPST2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TPST2
    PGOHUM00000246748


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TPST2 (see all 1501)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105400361,2
    C--10900311(+) TACAT-/ACA   
       CACAC
    ACACA
    1 -- int10--------
    rs1873430601,2
    C--26921215(+) ATTTTA/GAGATG 2 -- ds50010--------
    rs1892016371,2
    --26921259(+) TGGCAA/CGATCT 2 -- ds50010--------
    rs777122501,2
    C,F--26921301(+) AAGCCC/TCCTGA 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs106090741,2
    C--26921327(+) tgcac-/ACcacca 2 -- ds50010--------
    rs72880471,2
    C--26921382(+) accatA/Gttggc 2 -- ds50010--------
    rs1123406281,2
    C,F--26921388(+) TTGGCC/TAGGCT 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs42751,2
    C,F,O,A,H--26921725(+) AAAGTA/GAGGCA 2 -- ut3132Minor allele frequency- G:0.35NA PA MN EA NS WA CSA 3160
    rs780856351,2
    C--26921744(+) TGAGCC/GTCTGT 2 -- ut310--------
    rs762016041,2
    C--26921745(+) GAGCCC/TCTGTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TPST2 (26921458 - 26992681 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TPST2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724093CNV Deletion23290073
    nsv914954CNV Loss21882294
    nsv914955CNV Loss21882294
    dgv1397e1CNV Complex17122850
    nsv7350OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPST2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603126    OMIM disorders: --

    7 diseases for TPST2:    About MalaCards
    atherosclerosis    tonsillitis    hiv-1    endotheliitis
    pancreatitis    thyroiditis    cerebritis


    TPST2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPST2
    Human Genome Epidemiology (HuGE) Navigator: TPST2 (2 documents)

    Export disorders for TPST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TPST2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TPST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Existence of distinct tyrosylprotein sulfotransferase genes: molecular characterization of tyrosylprotein sulfotransferase-2. (PubMed id 9736702)1, 2, 3, 9 Beisswanger R.... Huttner W.B. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PubMed id 9733778)1, 2, 3, 9 Ouyang Y.-B. and Moore K.L. (J. Biol. Chem. 1998)
    3. Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction. (PubMed id 23481380)1, 2 Teramoto T....Kakuta Y. (Nat Commun 2013)
    4. Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis. (PubMed id 20460947)1, 4 Rosendahl J....Sahin-TA^th M. (Pancreatology 2010)
    5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8459 HGNC: 12021 AceView: TPST2 Ensembl:ENSG00000128294 euGenes: HUgn8459
    ECgene: TPST2 H-InvDB: TPST2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TPST2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TPST2 gene:
    Search GeneIP for patents involving TPST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for TPST2 (Tyrosylprotein Sulfotransferase 2/TPST2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TPST2 (Tyrosylprotein Sulfotransferase 2/TPST2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TPST2  
     OriGene qPCR primer pairs and template standards for TPST2   OriGene Protein Over-expression Lysate for TPST2  
     OriGene MassSpec something-or-other for TPST2   OriGene clones in human, mouse for TPST2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TPST2   OriGene Purified Protein for TPST2  
     OriGene ORF clones in mouse, rat for TPST2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TPST2   OriGene Custom Protein Services for TPST2  

     
     
     Block miRNA regulation of human, mouse, rat TPST2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TPST2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPST2 Predesigned siRNA for gene silencing in human, mouse, rat TPST2
     QuantiFast Probe-based Assays in human, mouse, rat TPST2 QuantiTect SYBR Green Assays in human, mouse, rat TPST2
     Custom PCR Arrays for TPST2 Search Chromatin IP Primers for TPST2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPST2  Search GeneGlobe Interaction Network for TPST2
     Regulatory tfbs in TPST2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TPST2 GenScript cDNA clones with any tag delivered in your preferred vector for TPST2
     GenScript Custom Assay Services for TPST2 GenScript Custom overexpressing Cell Line Services for TPST2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TPST2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TPST2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TPST2 antibodies
     TPST2 proteins
     TPST2 lysates
     Antibodies for TPST2
     See all of Abcam's Antibodies, Kits and Proteins for TPST2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TPST2
     Proteins for TPST2
     Antibodies for TPST2
     ELISAs for TPST2
     CLIAs for TPST2



     Browse ESI BIO Cell Lines and PureStem Progenitors for TPST2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST2
     SwitchGear 3'UTR luciferase reporter plasmids for TPST2
     SwitchGear Promoter luciferase reporter plasmids for TPST2
     ThermoFisher Antibodies for TPST2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPST2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TPST2
     LSBio Antibodies in human, mouse, rat for TPST2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TPST2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4