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Aliases for TPST1 Gene

Aliases for TPST1 Gene

  • Tyrosylprotein Sulfotransferase 1 2 3 4
  • EC 4 63
  • TPST-1 3 4
  • Transport And Golgi Organization 13 Homolog A (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog A 3
  • Protein-Tyrosine Sulfotransferase 1 3
  • Tyrosylprotein Sulfotransferase-1 3
  • TANGO13A 3

External Ids for TPST1 Gene

Previous GeneCards Identifiers for TPST1 Gene

  • GC07P064310
  • GC07P065068
  • GC07P065081
  • GC07P065114
  • GC07P065308
  • GC07P065670
  • GC07P061856

Summaries for TPST1 Gene

GeneCards Summary for TPST1 Gene

TPST1 (Tyrosylprotein Sulfotransferase 1) is a Protein Coding gene. GO annotations related to this gene include protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot for TPST1 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST1 Gene

Genomics for TPST1 Gene

Regulatory Elements for TPST1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPST1 Gene

66,205,199 bp from pter
66,420,543 bp from pter
215,345 bases
Plus strand

Genomic View for TPST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST1 Gene

Proteins for TPST1 Gene

  • Protein details for TPST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-tyrosine sulfotransferase 1
    Protein Accession:
    Secondary Accessions:
    • A4D2M0
    • Q6FGM7

    Protein attributes for TPST1 Gene

    370 amino acids
    Molecular mass:
    42188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPST1 Gene

Proteomics data for TPST1 Gene at MOPED

Post-translational modifications for TPST1 Gene

  • Glycosylation at Ser46, Thr47, Thr49, Thr50, Thr53, Asn60, Thr199, Asn262, Ser286, and Thr287
  • Modification sites at PhosphoSitePlus

Other Protein References for TPST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TPST1 Gene

Gene Families for TPST1 Gene

Protein Domains for TPST1 Gene


Suggested Antigen Peptide Sequences for TPST1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein sulfotransferase family.
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST1: view

Function for TPST1 Gene

Molecular function for TPST1 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides

Enzyme Numbers (IUBMB) for TPST1 Gene

Gene Ontology (GO) - Molecular Function for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0008476 protein-tyrosine sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with TPST1: view

Phenotypes for TPST1 Gene

genes like me logo Genes that share phenotypes with TPST1: view

Animal Models for TPST1 Gene

MGI Knock Outs for TPST1:

Animal Model Products

miRNA for TPST1 Gene

miRTarBase miRNAs that target TPST1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPST1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TPST1 Gene

Localization for TPST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for TPST1 Gene COMPARTMENTS Subcellular localization image for TPST1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016020 membrane TAS 9501187
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPST1: view

Pathways for TPST1 Gene

SuperPathways for TPST1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IEA --
GO:0006954 inflammatory response TAS 9501187
genes like me logo Genes that share ontologies with TPST1: view

No data available for Pathways by source for TPST1 Gene

Compounds for TPST1 Gene

(2) HMDB Compounds for TPST1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate

(3) Novoseek inferred chemical compound relationships for TPST1 Gene

Compound -log(P) Hits PubMed IDs
tpst 97.7 1
tyrosine sulfate 91.2 1
tyrosine 49.8 5
genes like me logo Genes that share compounds with TPST1: view

Transcripts for TPST1 Gene

Unigene Clusters for TPST1 Gene

Tyrosylprotein sulfotransferase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPST1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - -
SP5: - -

Relevant External Links for TPST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPST1 Gene

mRNA expression in normal human tissues for TPST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TPST1 Gene

This gene is overexpressed in Bone (57.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPST1 Gene

SOURCE GeneReport for Unigene cluster for TPST1 Gene Hs.421194

genes like me logo Genes that share expressions with TPST1: view

Expression partners for TPST1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPST1 Gene

Orthologs for TPST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TPST1 35
  • 93.06 (n)
  • 96.76 (a)
TPST1 36
  • 97 (a)
(Canis familiaris)
Mammalia TPST1 35
  • 93.06 (n)
  • 97.57 (a)
TPST1 36
  • 98 (a)
(Mus musculus)
Mammalia Tpst1 35
  • 89.28 (n)
  • 96.49 (a)
Tpst1 16
Tpst1 36
  • 96 (a)
(Pan troglodytes)
Mammalia TPST1 35
  • 99.91 (n)
  • 100 (a)
TPST1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tpst1 35
  • 89.28 (n)
  • 96.22 (a)
(Monodelphis domestica)
Mammalia TPST1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia TPST1 36
  • 88 (a)
(Gallus gallus)
Aves TPST1 35
  • 80 (n)
  • 92.16 (a)
TPST1 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst1 35
  • 76.81 (n)
  • 88.86 (a)
(Danio rerio)
Actinopterygii tpst1 35
  • 73.28 (n)
  • 83.62 (a)
tpst1 36
  • 82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000900 35
  • 61.21 (n)
  • 65.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango13 35
  • 58.85 (n)
  • 61.42 (a)
Tango13 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea F42G9.8 37
  • 39 (a)
Y111B2A.15 37
  • 64 (a)
tpst-1 35
  • 60.98 (n)
  • 64.81 (a)
tpst-1 36
  • 50 (a)
tpst-2 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for TPST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST1 Gene

Gene Tree for TPST1 (if available)
Gene Tree for TPST1 (if available)

Paralogs for TPST1 Gene

Paralogs for TPST1 Gene

(1) SIMAP similar genes for TPST1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TPST1: view

Variants for TPST1 Gene

Sequence variations from dbSNP and Humsavar for TPST1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs709595 -- 66,352,346(-) GGCAG(C/G)ACTGA intron-variant
rs709596 -- 66,360,926(-) TTATA(C/T)ACCCT downstream-variant-500B
rs778729 -- 66,359,432(-) CTTCA(A/G)GTGTC intron-variant
rs778730 -- 66,358,338(-) atata(A/T)aaaaa intron-variant
rs778731 -- 66,358,028(-) cggct(C/T)actgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST1 Gene

Variant ID Type Subtype PubMed ID
esv2664145 CNV Deletion 23128226
esv2063879 CNV Deletion 18987734
esv2677943 CNV Deletion 23128226
nsv508458 CNV Loss 20534489
nsv507395 CNV Insertion 20534489
nsv888326 CNV Gain 21882294

Relevant External Links for TPST1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST1 Gene

Disorders for TPST1 Gene

Relevant External Links for TPST1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TPST1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TPST1 Gene

Publications for TPST1 Gene

  1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PMID: 9501187) Ouyang Y.-B. … Moore K.L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang Y.-B. … Moore K.L. (J. Biol. Chem. 1998) 3 23
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PMID: 12169668) Seibert C. … Sakmar T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PMID: 18672380) Danan L.M. … Leary J.A. (J. Am. Soc. Mass Spectrom. 2008) 3 23

Products for TPST1 Gene

Sources for TPST1 Gene

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