Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPST1 Gene

Aliases for TPST1 Gene

  • Tyrosylprotein Sulfotransferase 1 2 3 4 5
  • EC 4 58
  • TPST-1 3 4
  • Transport And Golgi Organization 13 Homolog A (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog A 3
  • Protein-Tyrosine Sulfotransferase 1 3
  • TANGO13A 3

External Ids for TPST1 Gene

Previous GeneCards Identifiers for TPST1 Gene

  • GC07P064310
  • GC07P065068
  • GC07P065081
  • GC07P065114
  • GC07P065308
  • GC07P065670
  • GC07P061856

Summaries for TPST1 Gene

GeneCards Summary for TPST1 Gene

TPST1 (Tyrosylprotein Sulfotransferase 1) is a Protein Coding gene. Diseases associated with TPST1 include Shwachman-Diamond Syndrome. GO annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot for TPST1 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Additional gene information for TPST1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST1 Gene

Genomics for TPST1 Gene

Regulatory Elements for TPST1 Gene

Enhancers for TPST1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H066170 1 Ensembl ENCODE 21.2 -34.3 -34321 1.1 ELF3 SAP130 CEBPG RAD21 ZIC2 THRB RARA TEAD3 RBAK TRIM24 VKORC1L1 TPST1 CCT6P1 LOC100420547 ENSG00000234185 GC07P066196
GH07H066139 1 ENCODE 20 -63.5 -63536 4.2 PKNOX1 FOXA2 ATF1 MLX ARID4B YY1 FOS SP5 NFYC REST LOC100996437 VKORC1L1 TPST1 RABGEF1 KCTD7 PIR31229 GC07P066141 ENSG00000234185
GH07H066281 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +77.7 77705 3.3 FOXA2 SIN3A ZBTB40 YY1 ZNF766 FOS RUNX3 CAVIN1 USF2 CEBPB LOC100996437 GS1-124K5.4 CRCP TPST1 RABGEF1 KCTD7 GC07P066239 GC07P066346 RNU6-313P
GH07H066250 1.5 FANTOM5 ENCODE dbSUPER 11.7 +45.9 45919 1.9 PKNOX1 FOXA2 ATF1 FEZF1 RFX5 FOS ATF7 CREM CEBPB MEF2D LOC100996437 TPST1 RABGEF1 KCTD7 CCT6P1 VKORC1L1 GC07P066239 RNU6-313P GC07P066346
GH07H066144 1.5 FANTOM5 Ensembl ENCODE 11.4 -56.2 -56156 9.1 FOXA2 ARID4B RAD21 RARA YY1 FOS RCOR1 ETV6 RUNX3 CREM LOC100996437 VKORC1L1 GS1-124K5.4 RABGEF1 ENSG00000229180 TPST1 ASL GC07P066141 PIR31229 ENSG00000234185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPST1 on UCSC Golden Path with GeneCards custom track

Promoters for TPST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212934 301 1801 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3

Genomic Locations for TPST1 Gene

Genomic Locations for TPST1 Gene
215,345 bases
Plus strand

Genomic View for TPST1 Gene

Genes around TPST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST1 Gene

Proteins for TPST1 Gene

  • Protein details for TPST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-tyrosine sulfotransferase 1
    Protein Accession:
    Secondary Accessions:
    • A4D2M0
    • Q6FGM7

    Protein attributes for TPST1 Gene

    370 amino acids
    Molecular mass:
    42188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPST1 Gene

Selected DME Specific Peptides for TPST1 Gene


Post-translational modifications for TPST1 Gene

  • Glycosylation at Ser46, Asn60, posLast=199199, posLast=262262, and posLast=286286
  • Modification sites at PhosphoSitePlus

Domains & Families for TPST1 Gene

Gene Families for TPST1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for TPST1 Gene


Suggested Antigen Peptide Sequences for TPST1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein sulfotransferase family.
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST1: view

Function for TPST1 Gene

Molecular function for TPST1 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Enzyme Numbers (IUBMB) for TPST1 Gene

Phenotypes From GWAS Catalog for TPST1 Gene

Gene Ontology (GO) - Molecular Function for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008476 protein-tyrosine sulfotransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TPST1: view
genes like me logo Genes that share phenotypes with TPST1: view

Animal Models for TPST1 Gene

MGI Knock Outs for TPST1:

Animal Model Products

miRNA for TPST1 Gene

miRTarBase miRNAs that target TPST1

Clone Products

  • Addgene plasmids for TPST1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST1 Gene

Localization for TPST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPST1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane TAS 9501187
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPST1: view

Pathways & Interactions for TPST1 Gene

SuperPathways for TPST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IEA,IBA --
GO:0006954 inflammatory response TAS 9501187
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with TPST1: view

No data available for Pathways by source and SIGNOR curated interactions for TPST1 Gene

Drugs & Compounds for TPST1 Gene

(1) Drugs for TPST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TPST1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
genes like me logo Genes that share compounds with TPST1: view

Transcripts for TPST1 Gene

Unigene Clusters for TPST1 Gene

Tyrosylprotein sulfotransferase 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TPST1

Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - -
SP5: - -

Relevant External Links for TPST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPST1 Gene

This gene is overexpressed in Bone (57.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPST1 Gene

Protein tissue co-expression partners for TPST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPST1 Gene:


SOURCE GeneReport for Unigene cluster for TPST1 Gene:


Evidence on tissue expression from TISSUES for TPST1 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TPST1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPST1 Gene

Orthologs for TPST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPST1 33 34
  • 99.91 (n)
(Bos Taurus)
Mammalia TPST1 33 34
  • 93.06 (n)
(Canis familiaris)
Mammalia TPST1 33 34
  • 93.06 (n)
(Mus musculus)
Mammalia Tpst1 33 16 34
  • 89.28 (n)
(Rattus norvegicus)
Mammalia Tpst1 33
  • 89.28 (n)
(Ornithorhynchus anatinus)
Mammalia TPST1 34
  • 88 (a)
(Monodelphis domestica)
Mammalia TPST1 34
  • 83 (a)
(Gallus gallus)
Aves TPST1 33 34
  • 80 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst1 33
  • 76.81 (n)
(Danio rerio)
Actinopterygii tpst1 33 34
  • 73.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000900 33
  • 61.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango13 33 34
  • 58.85 (n)
(Caenorhabditis elegans)
Secernentea Y111B2A.15 35
  • 64 (a)
tpst-1 33 34
  • 60.98 (n)
F42G9.8 35
  • 39 (a)
tpst-2 34
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
Species where no ortholog for TPST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST1 Gene

Gene Tree for TPST1 (if available)
Gene Tree for TPST1 (if available)

Paralogs for TPST1 Gene

Paralogs for TPST1 Gene

(1) SIMAP similar genes for TPST1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TPST1: view

Variants for TPST1 Gene

Sequence variations from dbSNP and Humsavar for TPST1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000007360 -- 66,341,149(+) ATCCT(A/G)AGCAG intron-variant
rs1000047648 -- 66,293,737(+) GTAAA(C/T)CTAAT intron-variant
rs1000055980 -- 66,254,191(+) AATTT(-/G)GGGGG intron-variant
rs1000079758 -- 66,323,021(+) TGATG(C/T)TGAGC intron-variant
rs1000127791 -- 66,254,459(+) AGTGC(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST1 Gene

Variant ID Type Subtype PubMed ID
nsv508458 CNV deletion 20534489
nsv507395 OTHER sequence alteration 20534489
nsv1124221 CNV deletion 24896259
esv3613504 CNV loss 21293372
esv3571889 CNV loss 25503493
esv3541801 CNV deletion 23714750
esv3365953 CNV insertion 20981092
esv2761079 CNV gain+loss 21179565
esv2677943 CNV deletion 23128226
esv2664145 CNV deletion 23128226
esv2063879 CNV deletion 18987734

Variation tolerance for TPST1 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST1 Gene

Disorders for TPST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TPST1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
shwachman-diamond syndrome
  • pancreatic insufficiency and bone marrow dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search TPST1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TPST1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TPST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPST1 Gene

Publications for TPST1 Gene

  1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PMID: 9501187) Ouyang Yb … Moore KL (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 45 60
  4. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PMID: 18672380) Danan LM … Leary JA (Journal of the American Society for Mass Spectrometry 2008) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for TPST1 Gene

  • Addgene plasmids for TPST1

Sources for TPST1 Gene

Loading form....