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Aliases for TPST1 Gene

Aliases for TPST1 Gene

  • Tyrosylprotein Sulfotransferase 1 2 3 4 5
  • EC 2.8.2.20 4 61
  • TPST-1 3 4
  • Transport And Golgi Organization 13 Homolog A (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog A 3
  • Protein-Tyrosine Sulfotransferase 1 3
  • TANGO13A 3

External Ids for TPST1 Gene

Previous GeneCards Identifiers for TPST1 Gene

  • GC07P064310
  • GC07P065068
  • GC07P065081
  • GC07P065114
  • GC07P065308
  • GC07P065670
  • GC07P061856

Summaries for TPST1 Gene

GeneCards Summary for TPST1 Gene

TPST1 (Tyrosylprotein Sulfotransferase 1) is a Protein Coding gene. GO annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot for TPST1 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST1 Gene

Genomics for TPST1 Gene

Regulatory Elements for TPST1 Gene

Enhancers for TPST1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F066170 1 Ensembl ENCODE 21.2 -34.3 -34321 1.1 ELF3 SAP130 CEBPG THRB RAD21 ZIC2 RARA TEAD3 RBAK TRIM24 VKORC1L1 TPST1 ENSG00000234185 GC07P066196
GH07F066139 1 ENCODE 20 -63.5 -63536 4.2 PKNOX1 ATF1 MLX ARID4B YY1 FOS SP5 NFYC REST PPARG LOC100996437 VKORC1L1 TPST1 RABGEF1 KCTD7 GC07P066141 PIR31229 ENSG00000234185
GH07F066250 1.5 FANTOM5 Ensembl ENCODE 11.7 +45.9 45919 1.9 PKNOX1 ATF1 FEZF1 RFX5 FOS CREM CEBPB MEF2D PBX2 STAT3 LOC100996437 TPST1 RABGEF1 KCTD7 CCT6P1 VKORC1L1 GC07P066239 GC07P066346 RNU6-313P
GH07F066281 1.5 FANTOM5 Ensembl ENCODE 11.5 +77.7 77705 3.3 PTRF SIN3A ZBTB40 RAD21 RARA YY1 ZNF121 FOS USF2 CEBPB LOC100996437 GS1-124K5.4 CRCP TPST1 RABGEF1 KCTD7 GC07P066239 RNU6-313P GC07P066346
GH07F066144 1.5 FANTOM5 Ensembl ENCODE 11.4 -56.2 -56156 9.1 PKNOX1 ARID4B RAD21 RARA YY1 ZNF366 SCRT2 ETV6 FOS CREM LOC100996437 VKORC1L1 GS1-124K5.4 RABGEF1 ENSG00000229180 TPST1 ASL GC07P066141 PIR31229 ENSG00000234185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPST1 on UCSC Golden Path with GeneCards custom track

Promoters for TPST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000627438 802 3200 ATF1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 GLIS2

Genomic Location for TPST1 Gene

Chromosome:
7
Start:
66,205,199 bp from pter
End:
66,420,543 bp from pter
Size:
215,345 bases
Orientation:
Plus strand

Genomic View for TPST1 Gene

Genes around TPST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST1 Gene

Proteins for TPST1 Gene

  • Protein details for TPST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60507-TPST1_HUMAN
    Recommended name:
    Protein-tyrosine sulfotransferase 1
    Protein Accession:
    O60507
    Secondary Accessions:
    • A4D2M0
    • Q6FGM7

    Protein attributes for TPST1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPST1 Gene

Selected DME Specific Peptides for TPST1 Gene

O60507:
  • GKLKQNLL
  • LGYDPYANPP
  • YEQLVLHP
  • ETRVIPRIL
  • DQVIKPVN
  • SYRDCLTKWNRAIETMY
  • YLSRLFPN
  • LCNKDPF
  • RLDEAGVTD
  • IFIGGVPRSGTTLMRAMLDAHP
  • DMAVIAPMLA
  • MVRDGRA
  • RKVTIAGFDL
  • ACLVISSVTVFYL
  • CHHRIEERSQP
  • ALSKWVGKIP
  • ANPPNYG

Post-translational modifications for TPST1 Gene

  • Glycosylation at Ser 46, Asn 60, Thr 199, Asn 262, and Ser 286
  • Modification sites at PhosphoSitePlus

Domains & Families for TPST1 Gene

Gene Families for TPST1 Gene

Protein Domains for TPST1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPST1 Gene

Graphical View of Domain Structure for InterPro Entry

O60507

UniProtKB/Swiss-Prot:

TPST1_HUMAN :
  • Belongs to the protein sulfotransferase family.
Family:
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST1: view

Function for TPST1 Gene

Molecular function for TPST1 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Enzyme Numbers (IUBMB) for TPST1 Gene

Gene Ontology (GO) - Molecular Function for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008476 protein-tyrosine sulfotransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TPST1: view
genes like me logo Genes that share phenotypes with TPST1: view

Animal Models for TPST1 Gene

MGI Knock Outs for TPST1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPST1

miRNA for TPST1 Gene

miRTarBase miRNAs that target TPST1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPST1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST1 Gene

Localization for TPST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPST1 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IBA --
GO:0016020 membrane IEA,TAS 9501187
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPST1: view

Pathways & Interactions for TPST1 Gene

SuperPathways for TPST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006478 peptidyl-tyrosine sulfation IEA --
GO:0006954 inflammatory response TAS 9501187
genes like me logo Genes that share ontologies with TPST1: view

No data available for Pathways by source and SIGNOR curated interactions for TPST1 Gene

Drugs & Compounds for TPST1 Gene

(1) Drugs for TPST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TPST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with TPST1: view

Transcripts for TPST1 Gene

Unigene Clusters for TPST1 Gene

Tyrosylprotein sulfotransferase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TPST1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for TPST1 Gene

GeneLoc Exon Structure for
TPST1
ECgene alternative splicing isoforms for
TPST1

Expression for TPST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPST1 Gene

This gene is overexpressed in Bone (57.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPST1 Gene



Protein tissue co-expression partners for TPST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPST1 Gene:

TPST1

SOURCE GeneReport for Unigene cluster for TPST1 Gene:

Hs.421194
genes like me logo Genes that share expression patterns with TPST1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPST1 Gene

Orthologs for TPST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPST1 34 35
  • 99.91 (n)
cow
(Bos Taurus)
Mammalia TPST1 34 35
  • 93.06 (n)
dog
(Canis familiaris)
Mammalia TPST1 34 35
  • 93.06 (n)
mouse
(Mus musculus)
Mammalia Tpst1 34 16 35
  • 89.28 (n)
rat
(Rattus norvegicus)
Mammalia Tpst1 34
  • 89.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPST1 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPST1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPST1 34 35
  • 80 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst1 34
  • 76.81 (n)
zebrafish
(Danio rerio)
Actinopterygii tpst1 34 35
  • 73.28 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000900 34
  • 61.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango13 34 35
  • 58.85 (n)
worm
(Caenorhabditis elegans)
Secernentea Y111B2A.15 36
  • 64 (a)
tpst-1 34 35
  • 60.98 (n)
F42G9.8 36
  • 39 (a)
tpst-2 35
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for TPST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST1 Gene

ENSEMBL:
Gene Tree for TPST1 (if available)
TreeFam:
Gene Tree for TPST1 (if available)

Paralogs for TPST1 Gene

Paralogs for TPST1 Gene

(1) SIMAP similar genes for TPST1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TPST1: view

Variants for TPST1 Gene

Sequence variations from dbSNP and Humsavar for TPST1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000464 -- 66,312,922(+) AATGT(C/G)TCATT intron-variant
rs1002053 -- 66,333,558(+) GGAAG(A/G)TTAAA intron-variant
rs10081219 -- 66,211,494(+) TTCAT(C/T)ACTGC intron-variant
rs10215948 -- 66,282,799(+) GCATC(A/G)TATCT intron-variant
rs10224872 -- 66,294,786(+) TCTCC(A/T)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST1 Gene

Variant ID Type Subtype PubMed ID
nsv508458 CNV deletion 20534489
nsv507395 OTHER sequence alteration 20534489
nsv1124221 CNV deletion 24896259
esv3613504 CNV loss 21293372
esv3571889 CNV loss 25503493
esv3541801 CNV deletion 23714750
esv3365953 CNV insertion 20981092
esv2761079 CNV gain+loss 21179565
esv2677943 CNV deletion 23128226
esv2664145 CNV deletion 23128226
esv2063879 CNV deletion 18987734

Variation tolerance for TPST1 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPST1 Gene

Disorders for TPST1 Gene

Relevant External Links for TPST1

Genetic Association Database (GAD)
TPST1
Human Genome Epidemiology (HuGE) Navigator
TPST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPST1

No disorders were found for TPST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPST1 Gene

Publications for TPST1 Gene

  1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PMID: 9501187) Ouyang Y.-B. … Moore K.L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  4. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PMID: 18672380) Danan L.M. … Leary J.A. (J. Am. Soc. Mass Spectrom. 2008) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TPST1 Gene

Sources for TPST1 Gene

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