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TPST1 Gene

protein-coding   GIFtS: 58
GCID: GC07P065670

Tyrosylprotein Sulfotransferase 1

  See TPST1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tyrosylprotein Sulfotransferase 11 2 3     TANGO13A2
TPST-12 3     Protein-Tyrosine Sulfotransferase 12
EC 2.8.2.203 8     Transport And Golgi Organization 13 Homolog A2
Transport And Golgi Organization 13 Homolog A (Drosophila)1     Tyrosylprotein Sulfotransferase-12

External Ids:    HGNC: 120201   Entrez Gene: 84602   Ensembl: ENSG000001699027   OMIM: 6031255   UniProtKB: O605073   
ORGUL members:         

Export aliases for TPST1 gene to outside databases

Previous GC identifers: GC07P064310 GC07P065068 GC07P065081 GC07P065114 GC07P065308 GC07P061856


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TPST1 Gene:
TPST1 (tyrosylprotein sulfotransferase 1) is a protein-coding gene. Diseases associated with TPST1 include shwachman-diamond syndrome. GO annotations related to this gene include protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPST1 gene promoter:
         Max1   STAT5A   NF-kappaB   Max   NF-kappaB2   IRF-7A   c-Myb   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTPST1 promoter sequence
   Search Chromatin IP Primers for TPST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

TPST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPST1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P065670:  view genomic region     (about GC identifiers)

Start:
65,670,186 bp from pter      End:
65,885,530 bp from pter
Size:
215,345 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 65,007,777-65,162,926     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507 (See protein sequence)
Recommended Name: Protein-tyrosine sulfotransferase 1  
Size: 370 amino acids; 42188 Da
Secondary accessions: A4D2M0 Q6FGM7

Explore the universe of human proteins at neXtProt for TPST1: NX_O60507

Explore proteomics data for TPST1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Ser46, Thr47, Thr49, Thr50, Thr53, Asn60, Thr199, Asn262, Ser286, Thr287
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TPST1 (O60507) (see all 17)
     MVRDGRA  LCNKDPF  ANPPNYG  YEQLVLHP 


    See TPST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003587.1  
    ENSEMBL proteins: 
     ENSP00000302413   ENSP00000399642   ENSP00000391338  

    TPST1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TPST1 (Tyrosylprotein Sulfotransferase 1/TPST1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TPST1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TPST1
    GenScript Custom Purified and Recombinant Proteins Services for TPST1
    Novus Biologicals TPST1 Protein
    Sino Biological Recombinant Protein for TPST1
    Sino Biological Cell Lysate for TPST1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TPST1

     
    Search eBioscience for Proteins for TPST1 

     
    antibodies-online proteins for TPST1 (5 products) 

     
    Search antibodies-online for peptides for TPST1

    TPST1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for TPST1 at Abcam
    Cloud-Clone Corp. Antibodies for TPST1
    Search ThermoFisher Antibodies for TPST1
    antibodies-online antibodies for TPST1 (23 products) 

    TPST1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TPST1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TPST1
    Cloud-Clone Corp. CLIAs for TPST1
    Search eBioscience for ELISAs for TPST1 
    antibodies-online kits for TPST1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR026634 TPST

    Graphical View of Domain Structure for InterPro Entry O60507

    ProtoNet protein and cluster: O60507

    UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507
    Similarity: Belongs to the protein sulfotransferase family


    Find genes that share domains with TPST1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TPST1_HUMAN, O60507
    Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides
    Catalytic activity: 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein
    tyrosine-O-sulfate

         Genatlas biochemistry entry for TPST1:
    tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins

         Enzyme Number (IUBMB): EC 2.8.2.201 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0008476protein-tyrosine sulfotransferase activity IEA--
         
    Find genes that share ontologies with TPST1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TPST1:
     Increased influenza A virus in 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tpst1):
     behavior/neurological  growth/size/body  reproductive system 

    Find genes that share phenotypes with TPST1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tpst1tm1Klm for TPST1

       genOway: Develop your customized and physiologically relevant rodent model for TPST1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TPST1:
    hsa-mir-124-3p (MIRT022966)

    Block miRNA regulation of human, mouse, rat TPST1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPST1 (see all 10):
    hsa-miR-3163 hsa-miR-183* hsa-miR-23b hsa-miR-1283 hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPST1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TPST1
    Predesigned siRNA for gene silencing in human, mouse, rat TPST1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TPST1

    Clone
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    OriGene clones in human, mouse for TPST1 (see all 7)
    OriGene ORF clones in mouse, rat for TPST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TPST1 (NM_003596)
    Sino Biological Human cDNA Clone for TPST1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST1
    Addgene plasmids for TPST1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TPST1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TPST1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TPST1_HUMAN, O60507: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016020membrane TAS9501187
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TPST1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TPST1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TPST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TPST1 (O605073 ENSP000003024134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    SELPLGQ142423, ENSP000003736144I2D: score=1 STRING: ENSP00000373614
    CMKLR1Q997883, ENSP000003117334I2D: score=1 STRING: ENSP00000311733
    GPR1P460913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006478peptidyl-tyrosine sulfation IEA--
    GO:0006954inflammatory response TAS9501187

    Find genes that share ontologies with TPST1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPST1

    2 HMDB Compounds for TPST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--

    3 Novoseek inferred chemical compound relationships for TPST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tpst 97.7 1 19679829 (1)
    tyrosine sulfate 91.2 1 19658209 (1)
    tyrosine 49.8 6 17536277 (1), 18672380 (1), 12169668 (1), 19747829 (1) (see all 5)



    Find genes that share compounds with TPST1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TPST1 gene: 
    NM_003596.3  

    Unigene Cluster for TPST1:

    Tyrosylprotein sulfotransferase 1
    Hs.421194  [show with all ESTs]
    Unigene Representative Sequence: NM_003596
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304842(uc003tuw.3) ENST00000442120 ENST00000480281(uc010kzy.2)
    ENST00000451388 ENST00000490159
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TPST1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TPST1 (see all 10):
    hsa-miR-3163 hsa-miR-183* hsa-miR-23b hsa-miR-1283 hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmidTPST1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TPST1
    Predesigned siRNA for gene silencing in human, mouse, rat TPST1
    Clone
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    OriGene clones in human, mouse for TPST1 (see all 7)
    OriGene ORF clones in mouse, rat for TPST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TPST1 (NM_003596)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST1
    Addgene plasmids for TPST1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TPST1
    OriGene qSTAR qPCR primer pairs in human, mouse for TPST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPST1
      QuantiTect SYBR Green Assays in human, mouse, rat TPST1
      QuantiFast Probe-based Assays in human, mouse, rat TPST1

    Additional mRNA sequence: 

    AF038009.1 AK095722.1 AK307053.1 AK313098.1 BC013188.1 CR542060.1 CR542080.1 

    12 DOTS entries:

    DT.40108916  DT.100646200  DT.454354  DT.95135766  DT.91771597  DT.100646203  DT.95277702  DT.100050935 
    DT.100646204  DT.121063377  DT.97781314  DT.99974969 

    17 AceView cDNA sequences:

    BQ008597 CF130731 BU182794 BM973405 BU754507 BQ772798 AW052055 AL042921 
    CB111631 BG171166 CA418405 AW271308 BG192226 BU177660 BI868943 CK023633 
    CD692640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:              -                                   -     -     -           -     -               
    SP2:                                                  -     -     -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                          -     -               


    ECgene alternative splicing isoforms for TPST1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTAATGTT
    TPST1 Expression
    About this image


    TPST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TPST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TPST1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421194
        Pathway & Disease-focused RT2 Profiler PCR Array including TPST1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TPST1
    OriGene qSTAR qPCR primer pairs in human, mouse for TPST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TPST1
    QuantiTect SYBR Green Assays in human, mouse, rat TPST1
    QuantiFast Probe-based Assays in human, mouse, rat TPST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TPST1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tpst11 , 5 protein-tyrosine sulfotransferase 11, 5 89.28(n)1
    96.49(a)1
      5 (68.53 cM)5
    220211  NM_001130476.21  NP_001123948.11 
     1300733265 
    chicken
    (Gallus gallus)
    Aves TPST11 tyrosylprotein sulfotransferase 1 80(n)
    92.16(a)
      417546  XM_003642394.2  XP_003642442.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tpst11 tyrosylprotein sulfotransferase 1 76.81(n)
    88.86(a)
      595028  NM_001030469.1  NP_001025640.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tpst12 tyrosylprotein sulfotransferase 1 77.72(n)   30677  AF510736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango131 Transport and Golgi organization 13 58.85(n)
    61.42(a)
      32312  NM_167374.3  NP_727717.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y111B2A.153
    tpst-11
    protein-tyrosine sulphotransferase3
    tpst-11
    64(a)
    (best of 2)3
    60.98(n)1
    64.81(a)1
      III(12724206-12733848)3
    1766841  NM_067245.31  NP_499646.31 


    ENSEMBL Gene Tree for TPST1 (if available)
    TreeFam Gene Tree for TPST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPST1 gene
    TPST22  
    1 SIMAP similar gene for TPST1 using alignment to 5 protein entries:     TPST1_HUMAN (see all proteins):
    TPST2

    Find genes that share paralogs with TPST1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TPST1 (see all 2576)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414727241,2
    --65668339(+) CTCCTA/GCCTGG 1 -- us2k10--------
    rs1868210671,2
    --65668566(+) CTCCCA/GGGTTC 1 -- us2k10--------
    rs46360831,2
    C,A--65668650(+) tgtatG/Ttttag 1 -- us2k10--------
    rs44814721,2
    C,H--65668764(+) actgcG/Acccgg 1 -- us2k15Minor allele frequency- A:0.00NA WA CSA 8
    rs1905790131,2
    --65668810(+) AGCATC/TATGTA 1 -- us2k10--------
    rs1419736971,2
    --65668851(+) ATCAAC/TGGATT 1 -- us2k10--------
    rs1827787601,2
    --65668926(+) TGGGAA/GGCCAA 1 -- us2k10--------
    rs624655251,2
    C--65668993(+) ACCCCG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1177058331,2
    F--65669054(+) AGCTAC/TTTTGG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs284910911,2
    C,F--65669064(+) GAGGCT/GGAGGC 1 -- us2k18Minor allele frequency- G:0.35NA WA EA 368

    HapMap Linkage Disequilibrium report for TPST1 (65670186 - 65885530 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TPST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2063879CNV Deletion18987734
    esv2677943CNV Deletion23128226
    esv2664145CNV Deletion23128226
    nsv507395CNV Insertion20534489
    nsv508458CNV Loss20534489
    nsv888326CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603125    OMIM disorders: --

    1 disease for TPST1:    
    About MalaCards
    shwachman-diamond syndrome


    Find genes that share disorders with TPST1           About GenesLikeMe

    Genetic Association Database (GAD): TPST1
    Human Genome Epidemiology (HuGE) Navigator: TPST1 (2 documents)

    Export disorders for TPST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TPST1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with TPST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PubMed id 9501187)1, 2, 3 Ouyang Y.-B.... Moore K.L. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PubMed id 18672380)1, 9 Danan L.M....Leary J.A. (J. Am. Soc. Mass Spectrom. 2008)
    7. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PubMed id 12169668)1, 9 Seibert C....Sakmar T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PubMed id 9733778)1, 9 Ouyang Y.-B. and Moore K.L. (J. Biol. Chem. 1998)
    9. Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma. (PubMed id 23472069)1 Xu J....Cao Y. (PLoS ONE 2013)
    10. Determination of the sites of tyrosine O-sulfation in peptides and proteins. (PubMed id 17558413)1 Yu Y.... Leary J.A. (Nat. Methods 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8460 HGNC: 12020 AceView: TPST1.1 Ensembl:ENSG00000169902 euGenes: HUgn8460
    ECgene: TPST1 H-InvDB: TPST1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TPST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TPST1 gene:
    Search GeneIP for patents involving TPST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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