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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TPST1 Gene

protein-coding   GIFtS: 55
GCID: GC07P065670

tyrosylprotein sulfotransferase 1
 Explore 5 diseases affiliated with
TPST1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TPST1    

Aliases
for TPST1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tyrosylprotein Sulfotransferase 11 2 3     Protein-Tyrosine Sulfotransferase 12
TANGO13A1 2     Transport And Golgi Organization 13 Homolog A2
TPST-12 3     Tyrosylprotein Sulfotransferase-12
EC 2.8.2.203 8     

External Ids:    HGNC: 120201   Entrez Gene: 84602   Ensembl: ENSG000001699027   OMIM: 6031255   UniProtKB: O605073   

Export aliases for TPST1 gene to outside databases

Previous GC identifers: GC07P064310 GC07P065068 GC07P065081 GC07P065114 GC07P065308 GC07P061856


Summaries
for TPST1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507
Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides




Genomic Views
for TPST1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079593.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TPST1 gene promoter:
         Max1   STAT5A   NF-kappaB   Max   NF-kappaB2   IRF-7A   c-Myb   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TPST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TPST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

TPST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPST1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P065670:  view genomic region     (about GC identifiers)

Start:
 65,670,186 bp from pter      End:
 65,885,530 bp from pter
Size:
 215,345 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 65,007,777-65,162,926     

Proteins
for TPST1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507 (See protein sequence)
Recommended Name: Protein-tyrosine sulfotransferase 1  
Size: 370 amino acids; 42188 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: Q6FGM7

Explore the universe of human proteins at neXtProt for TPST1: NX_O60507

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60507

    • 4/17 DME Specific Peptides for TPST1 (O60507) (see all 17)
     MVRDGRA  LCNKDPF  ANPPNYG  YEQLVLHP 

    TPST1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003587.1  
    ENSEMBL proteins: 
     ENSP00000302413   ENSP00000399642   ENSP00000391338  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TPST1 (Tyrosylprotein Sulfotransferase 1/TPST1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TPST1
    OriGene Custom Protein Services for TPST1 
    GenScript Custom Purified and Recombinant Proteins Services for TPST1
    Novus Biologicals TPST1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TPST1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005624membrane fraction ----
    GO:0016020membrane TAS9501187
    GO:0016021integral to membrane IEA--


    TPST1 for ontologies           About GeneDecksing



    TPST1 Antibody Products: 
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    Uscn Antibodies for TPST1
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    Assay Products for TPST1: 
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    Uscn ELISAs and CLIAs for TPST1

    Protein Domains /
    Families
    for TPST1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TPST1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026634 TPST

    Graphical View of Domain Structure for InterPro Entry O60507

    ProtoNet protein and cluster: O60507

    UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507
    Similarity: Belongs to the protein sulfotransferase family


    Function
    for TPST1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TPST1_HUMAN, O60507
    Function: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides
    Catalytic activity: 3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein
    tyrosine-O-sulfate

         Genatlas biochemistry entry for TPST1:
    tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins

    Enzyme Number (IUBMB): EC 2.8.2.201 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPST1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TPST1 (see all 10):
    hsa-miR-3163 hsa-miR-183* hsa-miR-23b hsa-miR-1283 hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TPST1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPST1 (see all 7)
    OriGene shRNA RFP: TPST1
    OriGene siRNA: TPST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPST1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TPST1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPST1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPST1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
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    Sino Biological Human cDNA Clone for TPST1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TPST1
    Search LifeMap BioReagents cell lines for TPST1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008476protein-tyrosine sulfotransferase activity IEA--


    TPST1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TPST1:
     Increased influenza A virus in 

    Animal Models:
         Mouse knock-out Tpst1tm1Klm for TPST1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tpst1):
     behavior/neurological  growth/size  reproductive system 

    TPST1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TPST1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for TPST1 (O605073 ENSP000003024134) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCR8P516853, ENSP000003264324I2D: score=1 STRING: ENSP00000326432
    SELPLGQ142423, ENSP000003736144I2D: score=1 STRING: ENSP00000373614
    CCR1P322463, ENSP000002961404I2D: score=1 STRING: ENSP00000296140
    CMKLR1Q997883, ENSP000003117334I2D: score=1 STRING: ENSP00000311733
    GPR1P460913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006478peptidyl-tyrosine sulfation IEA--
    GO:0006954inflammatory response TAS9501187


    TPST1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TPST1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TPST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TPST1

    2 HMDB Compounds for TPST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    3 Novoseek chemical compound relationships for TPST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tpst 97.7 1 19679829 (1)
    tyrosine sulfate 91.2 1 19658209 (1)
    tyrosine 49.8 6 17536277 (1), 18672380 (1), 12169668 (1), 19747829 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TPST1 

    Transcripts
    for TPST1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TPST1 gene: 
    NM_003596.3  

    Unigene Cluster for TPST1:

    Tyrosylprotein sulfotransferase 1
    Hs.421194  [show with all ESTs]
    Unigene Representative Sequence: NM_003596
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304842(uc003tuw.3) ENST00000442120 ENST00000480281(uc010kzy.2)
    ENST00000451388 ENST00000490159

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TPST1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TPST1 (see all 10):
    hsa-miR-3163 hsa-miR-183* hsa-miR-23b hsa-miR-1283 hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-3145-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TPST1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPST1 (see all 7)
    OriGene shRNA RFP: TPST1
    OriGene siRNA: TPST1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TPST1
    Clone
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    GenScript: all cDNA clones in your preferred vector: TPST1 (NM_003596)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TPST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPST1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPST1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPST1

    Additional cDNA sequence: 

    AF038009.1 AK095722.1 AK307053.1 AK313098.1 BC013188.1 CR542060.1 CR542080.1 

    12 DOTS entries:

    DT.40108916  DT.100646200  DT.454354  DT.95135766  DT.91771597  DT.100646203  DT.95277702  DT.100050935 
    DT.100646204  DT.121063377  DT.97781314  DT.99974969 

    17 AceView cDNA sequences:

    BU182794 BQ772798 AL042921 BM973405 CF130731 BU754507 AW052055 BQ008597 
    BU177660 AW271308 CA418405 BG171166 BG192226 CB111631 BI868943 CD692640 
    CK023633 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
    SP1:              -                                   -     -     -           -     -               
    SP2:                                                  -     -     -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                          -     -               


    ECgene alternative splicing isoforms for TPST1

    Expression
    for TPST1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TPST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTAATGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TPST1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartRight VentricleHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TPST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TPST1

    SOURCE GeneReport for Unigene cluster: Hs.421194
        SABiosciences Expression via Pathway-Focused PCR Array including TPST1: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPST1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TPST1

    Orthologs
    for TPST1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TPST1 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TPST11 tyrosylprotein sulfotransferase 1 80(n)
    92.16(a)    		   417546  XM_003642394.1  XP_003642442.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tpst12 tyrosylprotein sulfotransferase 1 77.72(n)   30677  AF510736.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tango131 Transport and Golgi organization 13 59.26(n)
    61.86(a)    		   32312  NM_167374.2  NP_727717.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y111B2A.153
    tpst-11    		 protein-tyrosine sulphotransferase3
    Protein TPST-11    		 64(a)
    (best of 2)3
    61.29(n)1
    65.26(a)1    		   III(12724206-12733848)3
    1766841  NM_067245.21  NP_499646.31 


    ENSEMBL Gene Tree for TPST1 (if available)
    TreeFam Gene Tree for TPST1 (if available) 

    Paralogs
    for TPST1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TPST1 gene
    TPST22  
    1 SIMAP similar gene for TPST1 using alignment to 6 protein entries:     TPST1_HUMAN (see all proteins):
    TPST2

    TPST1 for paralogs           About GeneDecksing



    Genomic Variants
    for TPST1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2218 NCBI SNPs in TPST1 are shown (see all 2218)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1414727241,2
    		--65668339(+) CTCCTA/GCCTGG 1 -- us2k10--------
    rs1868210671,2
    		--65668566(+) CTCCCA/GGGTTC 1 -- us2k10--------
    rs46360831,2
    		C,A,--65668650(+) TGTATG/TTTTAG 1 -- us2k10--------
    rs44814721,2
    		C,H,--65668764(+) ACTGCG/ACCCGG 1 -- us2k15Minor allele frequency- A:0.00NA WA CSA 8
    rs1905790131,2
    		--65668810(+) AGCATC/TATGTA 1 -- us2k10--------
    rs1419736971,2
    		--65668851(+) ATCAAC/TGGATT 1 -- us2k10--------
    rs1827787601,2
    		--65668926(+) TGGGAA/GGCCAA 1 -- us2k10--------
    rs624655251,2
    		--65668993(+) ACCCCG/ATCTCT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1177058331,2
    		F,--65669054(+) AGCTAC/TTTTGG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs284910911,2
    		C,F,--65669064(+) GAGGCT/GGAGGC 1 -- us2k18Minor allele frequency- G:0.35NA WA EA 368

    HapMap Linkage Disequilibrium report for TPST1 (65670186 - 65885530 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TPST1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPST1
    DNA2.0 Custom Variant and Variant Library Synthesis for TPST1

    Disorders / Diseases
    for TPST1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TPST1 for disorders           About GeneDecksing

    OMIM gene information: 603125    OMIM disorders: --

    5 diseases for TPST1:    About MalaCards
    shwachman-diamond syndrome    rheumatoid arthritis    arthritis    atherosclerosis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: TPST1 (2 documents)

    Export disorders for TPST1 gene to outside databases

    Publications
    for TPST1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TPST1 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with TPST1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PubMed id 9501187)1, 2, 3 Ouyang Y.-B.... Moore K.L. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PubMed id 18672380)1, 9 Danan L.M....Leary J.A. (2008)
    4. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PubMed id 12169668)1, 9 Seibert C....Sakmar T.P. (2002)
    5. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PubMed id 9733778)1, 9 Ouyang Y.-B. and Moore K.L. (1998)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
    8. Determination of the sites of tyrosine O-sulfation in peptides and proteins. (PubMed id 17558413)1 Yu Y.... Leary J.A. (2007)
    9. Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. (PubMed id 16859706)1 Goettsch S....Hartmann-Fatu C. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for TPST1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TPST1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8460 HGNC: 12020 AceView: TPST1.1 Ensembl:ENSG00000169902 euGenes: HUgn8460
    ECgene: TPST1 H-InvDB: TPST1

    Other Databases showing TPST1 gene

    (According to HUGE)
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    Specialized Databases showing TPST1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TPST1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TPST1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TPST1 gene:
    Search GeneIP for patents involving TPST1

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