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Aliases for TPST1 Gene

Aliases for TPST1 Gene

  • Tyrosylprotein Sulfotransferase 1 2 3 4 5
  • EC 2.8.2.20 4 63
  • TPST-1 3 4
  • Transport And Golgi Organization 13 Homolog A (Drosophila) 2
  • Transport And Golgi Organization 13 Homolog A 3
  • Tyrosylprotein Sulfotransferase-1 3
  • TANGO13A 3

External Ids for TPST1 Gene

Previous GeneCards Identifiers for TPST1 Gene

  • GC07P064310
  • GC07P065068
  • GC07P065081
  • GC07P065114
  • GC07P065308
  • GC07P065670
  • GC07P061856

Summaries for TPST1 Gene

GeneCards Summary for TPST1 Gene

TPST1 (Tyrosylprotein Sulfotransferase 1) is a Protein Coding gene. GO annotations related to this gene include sulfotransferase activity and protein-tyrosine sulfotransferase activity. An important paralog of this gene is TPST2.

UniProtKB/Swiss-Prot for TPST1 Gene

  • Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPST1 Gene

Genomics for TPST1 Gene

Regulatory Elements for TPST1 Gene

Enhancers for TPST1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TPST1 on UCSC Golden Path with GeneCards custom track

Promoters for TPST1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TPST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPST1 Gene

Chromosome:
7
Start:
66,205,199 bp from pter
End:
66,420,543 bp from pter
Size:
215,345 bases
Orientation:
Plus strand

Genomic View for TPST1 Gene

Genes around TPST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPST1 Gene

Proteins for TPST1 Gene

  • Protein details for TPST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60507-TPST1_HUMAN
    Recommended name:
    Protein-tyrosine sulfotransferase 1
    Protein Accession:
    O60507
    Secondary Accessions:
    • A4D2M0
    • Q6FGM7

    Protein attributes for TPST1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPST1 Gene

Proteomics data for TPST1 Gene at MOPED

Post-translational modifications for TPST1 Gene

  • Glycosylation at Ser 46, Asn 60, Thr 199, Asn 262, and Ser 286
  • Modification sites at PhosphoSitePlus

Other Protein References for TPST1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TPST1 Gene

Gene Families for TPST1 Gene

Protein Domains for TPST1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TPST1 Gene

Graphical View of Domain Structure for InterPro Entry

O60507

UniProtKB/Swiss-Prot:

TPST1_HUMAN :
  • Belongs to the protein sulfotransferase family.
Family:
  • Belongs to the protein sulfotransferase family.
genes like me logo Genes that share domains with TPST1: view

Function for TPST1 Gene

Molecular function for TPST1 Gene

GENATLAS Biochemistry:
tyrosylprotein sulfotransferase 1,54/50kDa,catalyzing tyrosine o-sulfatin of proteins
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + protein tyrosine = adenosine 3,5-bisphosphate + protein tyrosine-O-sulfate.
UniProtKB/Swiss-Prot Function:
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Enzyme Numbers (IUBMB) for TPST1 Gene

genes like me logo Genes that share phenotypes with TPST1: view

Animal Models for TPST1 Gene

MGI Knock Outs for TPST1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TPST1

miRNA for TPST1 Gene

miRTarBase miRNAs that target TPST1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TPST1 Gene

Localization for TPST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPST1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPST1 Gene COMPARTMENTS Subcellular localization image for TPST1 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
genes like me logo Genes that share ontologies with TPST1: view

Pathways & Interactions for TPST1 Gene

SuperPathways for TPST1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TPST1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPST1 Gene

Drugs & Compounds for TPST1 Gene

(1) Drugs for TPST1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TPST1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with TPST1: view

Transcripts for TPST1 Gene

Unigene Clusters for TPST1 Gene

Tyrosylprotein sulfotransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b
SP1: - - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for TPST1 Gene

GeneLoc Exon Structure for
TPST1
ECgene alternative splicing isoforms for
TPST1

Expression for TPST1 Gene

mRNA expression in normal human tissues for TPST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPST1 Gene

This gene is overexpressed in Bone (57.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TPST1 Gene



SOURCE GeneReport for Unigene cluster for TPST1 Gene Hs.421194

genes like me logo Genes that share expression patterns with TPST1: view

Protein tissue co-expression partners for TPST1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TPST1 Gene

Orthologs for TPST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TPST1 35
  • 93.06 (n)
  • 96.76 (a)
TPST1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TPST1 35
  • 93.06 (n)
  • 97.57 (a)
TPST1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpst1 35
  • 89.28 (n)
  • 96.49 (a)
Tpst1 16
Tpst1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPST1 35
  • 99.91 (n)
  • 100 (a)
TPST1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpst1 35
  • 89.28 (n)
  • 96.22 (a)
oppossum
(Monodelphis domestica)
Mammalia TPST1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TPST1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TPST1 35
  • 80 (n)
  • 92.16 (a)
TPST1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tpst1 35
  • 76.81 (n)
  • 88.86 (a)
zebrafish
(Danio rerio)
Actinopterygii tpst1 35
  • 73.28 (n)
  • 83.62 (a)
tpst1 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000900 35
  • 61.21 (n)
  • 65.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango13 35
  • 58.85 (n)
  • 61.42 (a)
Tango13 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F42G9.8 37
  • 39 (a)
Y111B2A.15 37
  • 64 (a)
tpst-1 35
  • 60.98 (n)
  • 64.81 (a)
tpst-1 36
  • 50 (a)
ManyToMany
tpst-2 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for TPST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPST1 Gene

ENSEMBL:
Gene Tree for TPST1 (if available)
TreeFam:
Gene Tree for TPST1 (if available)

Paralogs for TPST1 Gene

Paralogs for TPST1 Gene

(1) SIMAP similar genes for TPST1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TPST1: view

Variants for TPST1 Gene

Sequence variations from dbSNP and Humsavar for TPST1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs778729 -- 66,359,432(-) CTTCA(A/G)GTGTC intron-variant, downstream-variant-500B
rs778730 -- 66,358,338(-) atata(A/T)aaaaa intron-variant
rs778731 -- 66,358,028(-) cggct(C/T)actgt intron-variant
rs778732 -- 66,357,373(-) CACAC(A/G)AAGAA intron-variant
rs778733 -- 66,355,390(-) tcaag(C/T)gattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TPST1 Gene

Variant ID Type Subtype PubMed ID
esv2664145 CNV Deletion 23128226
esv2063879 CNV Deletion 18987734
esv2677943 CNV Deletion 23128226
nsv508458 CNV Loss 20534489
nsv507395 CNV Insertion 20534489
nsv888326 CNV Gain 21882294

Variation tolerance for TPST1 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TPST1 Gene

Disorders for TPST1 Gene

Relevant External Links for TPST1

Genetic Association Database (GAD)
TPST1
Human Genome Epidemiology (HuGE) Navigator
TPST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPST1

No disorders were found for TPST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPST1 Gene

Publications for TPST1 Gene

  1. Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins. (PMID: 9501187) Ouyang Y.-B. … Moore K.L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. (PMID: 18672380) Danan L.M. … Leary J.A. (J. Am. Soc. Mass Spectrom. 2008) 3 23
  3. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. (PMID: 12169668) Seibert C. … Sakmar T.P. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  4. Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans. (PMID: 9733778) Ouyang Y.-B. … Moore K.L. (J. Biol. Chem. 1998) 3 23
  5. Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer. (PMID: 25079514) Kim J.G. … Choi G.S. (J. Cancer Res. Clin. Oncol. 2015) 3

Products for TPST1 Gene

Sources for TPST1 Gene

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