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Aliases for TPSG1 Gene

Aliases for TPSG1 Gene

  • Tryptase Gamma 1 2 3 5
  • Transmembrane Tryptase 3 4
  • Serine Protease 31 3 4
  • Tryptase Gamma II 2 3
  • Tryptase Gamma I 2 3
  • PRSS31 3 4
  • TMT 3 4
  • Tryptase Gamma 3
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • TrpA 3

External Ids for TPSG1 Gene

Previous GeneCards Identifiers for TPSG1 Gene

  • GC16M001288
  • GC16M001212
  • GC16M001208
  • GC16M001213
  • GC16M001204
  • GC16M001271

Summaries for TPSG1 Gene

Entrez Gene Summary for TPSG1 Gene

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPSG1 Gene

TPSG1 (Tryptase Gamma 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is PRSS8.

Gene Wiki entry for TPSG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSG1 Gene

Genomics for TPSG1 Gene

Regulatory Elements for TPSG1 Gene

Enhancers for TPSG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002147 1.8 FANTOM5 Ensembl ENCODE 10.3 -929.4 -929407 17.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ENSG00000261505 HN1L ENSG00000260954 LOC105371055 ENSG00000260051 ENSG00000255513 TRAF7 SNORA64 ZNF598 ERVK13-1
GH16F001244 1.2 FANTOM5 Ensembl ENCODE 14.4 -19.0 -19003 1.2 TFDP1 ZNF316 MAFG NFE2 EMSY GABPA TPSD1 TPSAB1 TPSB2 TPSG1 LOC105379540
GH16F000806 1.6 FANTOM5 Ensembl ENCODE 10.3 +418.8 418772 2.8 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 KLF13 JMJD8 TMEM204 MPG TPSG1 ENSG00000260954 CHTF18 MSLN SOX8 FBXL16 RHBDL1
GH16F000523 1.5 FANTOM5 ENCODE 10.3 +698.6 698593 7.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NHLRC4 JMJD8 PRR35 PIGQ ENSG00000261505 MPG LOC105371038 TPSG1 ENSG00000260022 ENSG00000260051
GH16F001296 1.4 Ensembl ENCODE 10.5 -72.8 -72800 5.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF143 FOS KLF13 ZNF263 ENSG00000261505 ENSG00000260954 JMJD8 ENSG00000226890 BAIAP3 ENSG00000200059 PRSS29P ENSG00000261240 ZNF598 UBE2I
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TPSG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TPSG1 Gene

1,221,488 bp from pter
1,226,384 bp from pter
4,897 bases
Minus strand

Genomic View for TPSG1 Gene

Genes around TPSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPSG1 Gene

Proteins for TPSG1 Gene

  • Protein details for TPSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tryptase gamma
    Protein Accession:
    Secondary Accessions:
    • Q96RZ8
    • Q9C015
    • Q9NRQ8
    • Q9UBB2

    Protein attributes for TPSG1 Gene

    321 amino acids
    Molecular mass:
    33815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPSG1 Gene

Selected DME Specific Peptides for TPSG1 Gene


Post-translational modifications for TPSG1 Gene

Other Protein References for TPSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TPSG1 Gene

Gene Families for TPSG1 Gene

Suggested Antigen Peptide Sequences for TPSG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
genes like me logo Genes that share domains with TPSG1: view

Function for TPSG1 Gene

Enzyme Numbers (IUBMB) for TPSG1 Gene

Gene Ontology (GO) - Molecular Function for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 10521469
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with TPSG1: view
genes like me logo Genes that share phenotypes with TPSG1: view

Animal Model Products

miRNA for TPSG1 Gene

miRTarBase miRNAs that target TPSG1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPSG1 Gene

Localization for TPSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPSG1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPSG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10521469
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TPSG1: view

Pathways & Interactions for TPSG1 Gene

SuperPathways for TPSG1 Gene

No Data Available

Interacting Proteins for TPSG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000234798 Q9NRR2-TRYG1_HUMAN for TPSG1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TPSG1: view

No data available for Pathways by source and SIGNOR curated interactions for TPSG1 Gene

Drugs & Compounds for TPSG1 Gene

(14) Drugs for TPSG1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TPSG1: view

Transcripts for TPSG1 Gene

mRNA/cDNA for TPSG1 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPSG1 Gene

Tryptase gamma 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPSG1 Gene

No ASD Table

Relevant External Links for TPSG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPSG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TPSG1 Gene

mRNA differential expression in normal tissues according to GTEx for TPSG1 Gene

This gene is overexpressed in Colon - Transverse (x12.3) and Small Intestine - Terminal Ileum (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of TPSG1 Gene:


SOURCE GeneReport for Unigene cluster for TPSG1 Gene:


mRNA Expression by UniProt/SwissProt for TPSG1 Gene:

Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with TPSG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TPSG1 Gene

Orthologs for TPSG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPSG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tpsg1 34 16 35
  • 76.34 (n)
(Rattus norvegicus)
Mammalia Tpsg1 34
  • 76.29 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
-- 35
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 38 (a)
-- 35
  • 38 (a)
-- 35
  • 32 (a)
-- 35
  • 14 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11192 36
  • 39 (a)
CG4998 36
  • 38 (a)
CG7432 36
  • 38 (a)
CG18065 36
  • 37 (a)
mas 36
  • 37 (a)
Species where no ortholog for TPSG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPSG1 Gene

Gene Tree for TPSG1 (if available)
Gene Tree for TPSG1 (if available)

Paralogs for TPSG1 Gene Pseudogenes for TPSG1 Gene

genes like me logo Genes that share paralogs with TPSG1: view

Variants for TPSG1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TPSG1 Gene

There are two alleles; gamma-I and gamma-II which differ by 5 residues.

Sequence variations from dbSNP and Humsavar for TPSG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1004041 -- 1,221,890(-) GGCTT(A/C)TTCCT downstream-variant-500B, reference, missense
rs1054648 -- 1,221,471(+) CCACC(C/T)TCCCC downstream-variant-500B, utr-variant-3-prime
rs1054649 -- 1,221,597(+) ATGCG(A/T)ATCAG downstream-variant-500B, utr-variant-3-prime
rs1060341 -- 1,228,424(+) GGCCC(A/G)GTGCA upstream-variant-2KB, utr-variant-3-prime
rs1060344 -- 1,228,414(-) CCTCC(A/G)GCCCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TPSG1 Gene

Variant ID Type Subtype PubMed ID
nsv952899 CNV deletion 24416366
nsv833117 CNV loss 17160897
nsv7274 OTHER inversion 18451855
nsv571109 CNV gain 21841781
nsv571108 CNV loss 21841781
nsv571105 CNV loss 21841781
nsv571102 CNV loss 21841781
nsv571101 CNV gain 21841781
nsv471066 CNV loss 18288195
nsv428316 CNV gain+loss 18775914
nsv1160327 CNV deletion 26073780
nsv1051302 CNV gain 25217958
nsv1046885 CNV gain 25217958
esv3892754 CNV loss 25118596
esv2422427 CNV duplication 17116639
esv1000058 OTHER inversion 20482838
dgv2692n100 CNV gain 25217958
dgv2691n100 CNV gain 25217958

Variation tolerance for TPSG1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPSG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for TPSG1 Gene

Relevant External Links for TPSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TPSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPSG1 Gene

Publications for TPSG1 Gene

  1. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. (PMID: 10521469) Wong G.W. … Stevens R.L. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. (PMID: 12194977) Wong G.W. … Stevens R.L. (J. Biol. Chem. 2002) 3 22 64
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64
  4. Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. (PMID: 10843716) Caughey G.H. … Verghese G.M. (J. Immunol. 2000) 3 4 64
  5. Mast cell tryptase promotes breast cancer migration and invasion. (PMID: 20126998) Xiang M. … Yin L. (Oncol. Rep. 2010) 3 64

Products for TPSG1 Gene

Sources for TPSG1 Gene

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