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Aliases for TPSG1 Gene

Aliases for TPSG1 Gene

  • Tryptase Gamma 1 2 3 5
  • Transmembrane Tryptase 3 4
  • Serine Protease 31 3 4
  • Tryptase Gamma II 2 3
  • Tryptase Gamma I 2 3
  • PRSS31 3 4
  • TMT 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • TrpA 3

External Ids for TPSG1 Gene

Previous GeneCards Identifiers for TPSG1 Gene

  • GC16M001288
  • GC16M001212
  • GC16M001208
  • GC16M001213
  • GC16M001204
  • GC16M001271

Summaries for TPSG1 Gene

Entrez Gene Summary for TPSG1 Gene

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPSG1 Gene

TPSG1 (Tryptase Gamma 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

Gene Wiki entry for TPSG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSG1 Gene

Genomics for TPSG1 Gene

Regulatory Elements for TPSG1 Gene

Genomic Location for TPSG1 Gene

Chromosome:
16
Start:
1,221,488 bp from pter
End:
1,226,384 bp from pter
Size:
4,897 bases
Orientation:
Minus strand

Genomic View for TPSG1 Gene

Genes around TPSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPSG1 Gene

Proteins for TPSG1 Gene

  • Protein details for TPSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRR2-TRYG1_HUMAN
    Recommended name:
    Tryptase gamma
    Protein Accession:
    Q9NRR2
    Secondary Accessions:
    • Q96RZ8
    • Q9C015
    • Q9NRQ8
    • Q9UBB2

    Protein attributes for TPSG1 Gene

    Size:
    321 amino acids
    Molecular mass:
    33815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPSG1 Gene

Proteomics data for TPSG1 Gene at MOPED

Selected DME Specific Peptides for TPSG1 Gene

Post-translational modifications for TPSG1 Gene

Other Protein References for TPSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TPSG1 (Tryptase gamma-1/TPSG1)

Domains & Families for TPSG1 Gene

Gene Families for TPSG1 Gene

Suggested Antigen Peptide Sequences for TPSG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRR2

UniProtKB/Swiss-Prot:

TRYG1_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Tryptase subfamily.
genes like me logo Genes that share domains with TPSG1: view

Function for TPSG1 Gene

Enzyme Numbers (IUBMB) for TPSG1 Gene

genes like me logo Genes that share phenotypes with TPSG1: view

Animal Model Products

miRNA for TPSG1 Gene

miRTarBase miRNAs that target TPSG1

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPSG1 Gene

Localization for TPSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPSG1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPSG1 Gene COMPARTMENTS Subcellular localization image for TPSG1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TPSG1 Gene

Pathways & Interactions for TPSG1 Gene

SuperPathways for TPSG1 Gene

No Data Available

Interacting Proteins for TPSG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000234798%0d%0a9606.ENSP00000358525%0d%0a9606.ENSP00000369399%0d%0a
Selected Interacting proteins: ENSP00000234798 for TPSG1 Gene via STRING

Gene Ontology (GO) - Biological Process for TPSG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TPSG1 Gene

Drugs & Compounds for TPSG1 Gene

(14) Drugs for TPSG1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE Experimental Pharma Target 0
2-[(2-NAPHTHYLSULFONYL)AMINO]ETHYL DIHYDROGEN PHOSPHATE Experimental Pharma Target 0
2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE Experimental Pharma Target 0
4-(2-HYDROXY-4-FLUOROPHENYLTHIO)-BUTYLPHOSPHONIC ACID Experimental Pharma Target 0
4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID Experimental Pharma Target 0
genes like me logo Genes that share compounds with TPSG1: view

Transcripts for TPSG1 Gene

mRNA/cDNA for TPSG1 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPSG1 Gene

Tryptase gamma 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TPSG1 Gene

No ASD Table

Relevant External Links for TPSG1 Gene

GeneLoc Exon Structure for
TPSG1
ECgene alternative splicing isoforms for
TPSG1

Expression for TPSG1 Gene

mRNA expression in normal human tissues for TPSG1 Gene

mRNA differential expression in normal tissues according to GTEx for TPSG1 Gene

This gene is overexpressed in Colon - Transverse (x12.3) and Small Intestine - Terminal Ileum (x4.5).

SOURCE GeneReport for Unigene cluster for TPSG1 Gene Hs.592076

mRNA Expression by UniProt/SwissProt for TPSG1 Gene

Q9NRR2-TRYG1_HUMAN
Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with TPSG1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TPSG1 Gene

Orthologs for TPSG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPSG1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tpsg1 35
  • 76.34 (n)
  • 73.38 (a)
Tpsg1 16
Tpsg1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tpsg1 35
  • 76.29 (n)
  • 73.49 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11192 37
  • 39 (a)
CG18065 37
  • 37 (a)
CG4998 37
  • 38 (a)
CG7432 37
  • 38 (a)
mas 37
  • 37 (a)
Species with no ortholog for TPSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPSG1 Gene

ENSEMBL:
Gene Tree for TPSG1 (if available)
TreeFam:
Gene Tree for TPSG1 (if available)

Paralogs for TPSG1 Gene

Pseudogenes.org Pseudogenes for TPSG1 Gene

genes like me logo Genes that share paralogs with TPSG1: view

Variants for TPSG1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TPSG1 Gene

Q9NRR2-TRYG1_HUMAN
There are two alleles; gamma-I and gamma-II which differ by 5 residues.

Sequence variations from dbSNP and Humsavar for TPSG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs760357 - 1,223,490(-) GGAGG(A/G)TGCAC reference, missense
VAR_012098 -
VAR_012099 -
VAR_012100 -
VAR_012101 -

Structural Variations from Database of Genomic Variants (DGV) for TPSG1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2504n71 CNV Loss 21882294
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2514n71 CNV Loss 21882294
dgv2518n71 CNV Loss 21882294
dgv2520n71 CNV Loss 21882294
nsv904937 CNV Gain 21882294
dgv2522n71 CNV Loss 21882294
dgv2523n71 CNV Loss 21882294
dgv2524n71 CNV Gain+Loss 21882294
nsv904948 CNV Gain 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv904955 CNV Loss 21882294
nsv7274 OTHER Inversion 18451855
nsv904956 CNV Gain 21882294
nsv904957 CNV Loss 21882294
dgv2526n71 CNV Loss 21882294
nsv833117 CNV Loss 17160897
esv1000058 OTHER Inversion 20482838

Variation tolerance for TPSG1 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TPSG1 Gene

HapMap Linkage Disequilibrium report
TPSG1

Disorders for TPSG1 Gene

Relevant External Links for TPSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TPSG1

No disorders were found for TPSG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPSG1 Gene

Publications for TPSG1 Gene

  1. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. (PMID: 10521469) Wong G.W. … Stevens R.L. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. (PMID: 12194977) Wong G.W. … Stevens R.L. (J. Biol. Chem. 2002) 3 23
  3. Mast cell tryptase promotes breast cancer migration and invasion. (PMID: 20126998) Xiang M. … Yin L. (Oncol. Rep. 2010) 3
  4. Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity. (PMID: 17498058) Stevens R.L. … Adachi R. (Immunol. Rev. 2007) 23
  5. Expression and characterization of recombinant gamma-tryptase. (PMID: 16815034) Yuan J. … Clark J.M. (Protein Expr. Purif. 2006) 23

Products for TPSG1 Gene

Sources for TPSG1 Gene

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