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Aliases for TPSG1 Gene

Aliases for TPSG1 Gene

  • Tryptase Gamma 1 2 3
  • TMT 3 4 6
  • Transmembrane Tryptase 3 4
  • Serine Protease 31 3 4
  • Tryptase Gamma II 2 3
  • Tryptase Gamma I 2 3
  • PRSS31 3 4
  • Mast Cell Protease II 3
  • Mast Cell Tryptase 3
  • Pituitary Tryptase 3
  • Tryptase Gamma 3
  • Lung Tryptase 3
  • Skin Tryptase 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Gamma II 3
  • Gamma I 3
  • TrpA 3

External Ids for TPSG1 Gene

Previous GeneCards Identifiers for TPSG1 Gene

  • GC16M001288
  • GC16M001212
  • GC16M001208
  • GC16M001213
  • GC16M001204
  • GC16M001271

Summaries for TPSG1 Gene

Entrez Gene Summary for TPSG1 Gene

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPSG1 Gene

TPSG1 (Tryptase Gamma 1) is a Protein Coding gene. Diseases associated with TPSG1 include asthma. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

Gene Wiki entry for TPSG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSG1 Gene

Genomics for TPSG1 Gene

Regulatory Elements for TPSG1 Gene

Genomic Location for TPSG1 Gene

1,221,488 bp from pter
1,225,257 bp from pter
3,770 bases
Minus strand

Genomic View for TPSG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPSG1 Gene

Proteins for TPSG1 Gene

  • Protein details for TPSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tryptase gamma
    Protein Accession:
    Secondary Accessions:
    • Q96RZ8
    • Q9C015
    • Q9NRQ8
    • Q9UBB2

    Protein attributes for TPSG1 Gene

    321 amino acids
    Molecular mass:
    33815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TPSG1 Gene

Proteomics data for TPSG1 Gene at MOPED

Selected DME Specific Peptides for TPSG1 Gene

Post-translational modifications for TPSG1 Gene

Other Protein References for TPSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TPSG1 (Tryptase gamma-1/TPSG1)

Domains for TPSG1 Gene

Gene Families for TPSG1 Gene

Suggested Antigen Peptide Sequences for TPSG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
genes like me logo Genes that share domains with TPSG1: view

Function for TPSG1 Gene

Enzyme Numbers (IUBMB) for TPSG1 Gene

Gene Ontology (GO) - Molecular Function for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 10521469
genes like me logo Genes that share ontologies with TPSG1: view

miRNA for TPSG1 Gene

miRTarBase miRNAs that target TPSG1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSG1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TPSG1 Gene

Localization for TPSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPSG1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TPSG1 Gene COMPARTMENTS Subcellular localization image for TPSG1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 10521469
genes like me logo Genes that share ontologies with TPSG1: view

Pathways for TPSG1 Gene

SuperPathways for TPSG1 Gene

No Data Available

Interacting Proteins for TPSG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000234798 for TPSG1 Gene via STRING

Gene Ontology (GO) - Biological Process for TPSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TPSG1: view

No data available for Pathways by source for TPSG1 Gene

Drugs for TPSG1 Gene

(13) Drugbank Compounds for TPSG1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
16122526 Target experimental
11473003 Target experimental
16122525 Target experimental
5288544 Target experimental
46937110 Target experimental

(1) Novoseek inferred chemical compound relationships for TPSG1 Gene

Compound -log(P) Hits PubMed IDs
serine 53.5 3
genes like me logo Genes that share compounds with TPSG1: view

Transcripts for TPSG1 Gene

mRNA/cDNA for TPSG1 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TPSG1 Gene

Tryptase gamma 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPSG1 Gene

No ASD Table

Relevant External Links for TPSG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPSG1 Gene

mRNA expression in normal human tissues for TPSG1 Gene

mRNA differential expression in normal tissues according to GTEx for TPSG1 Gene

This gene is overexpressed in Colon - Transverse (12.3) and Small Intestine - Terminal Ileum (4.5).

SOURCE GeneReport for Unigene cluster for TPSG1 Gene Hs.592076

mRNA Expression by UniProt/SwissProt for TPSG1 Gene

Tissue specificity: Expressed in many tissues
genes like me logo Genes that share expressions with TPSG1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for TPSG1 Gene

Orthologs for TPSG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPSG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tpsg1 35
  • 76.34 (n)
  • 73.38 (a)
Tpsg1 16
Tpsg1 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Tpsg1 35
  • 76.29 (n)
  • 73.49 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
-- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
-- 36
  • 32 (a)
-- 36
  • 38 (a)
-- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11192 37
  • 39 (a)
CG18065 37
  • 37 (a)
CG4998 37
  • 38 (a)
CG7432 37
  • 38 (a)
mas 37
  • 37 (a)
Species with no ortholog for TPSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPSG1 Gene

Gene Tree for TPSG1 (if available)
Gene Tree for TPSG1 (if available)

Paralogs for TPSG1 Gene Pseudogenes for TPSG1 Gene

genes like me logo Genes that share paralogs with TPSG1: view

Variants for TPSG1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TPSG1 Gene

There are two alleles; gamma-I and gamma-II which differ by 5 residues

Sequence variations from dbSNP and Humsavar for TPSG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs760357 - 1,223,490(-) GGAGG(A/G)TGCAC missense, reference
rs909920 -- 1,223,638(+) AAGAA(A/G)CCCAC intron-variant, synonymous-codon, reference
rs909921 -- 1,223,803(+) TCGTC(C/T)TTTCT intron-variant, utr-variant-5-prime
rs1883562 -- 1,223,929(+) GTGCT(A/G)GGGGT intron-variant, utr-variant-5-prime
rs2294608 -- 1,222,722(+) GCCTC(C/T)GGGAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TPSG1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2504n71 CNV Loss 21882294
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2514n71 CNV Loss 21882294
dgv2518n71 CNV Loss 21882294
dgv2520n71 CNV Loss 21882294
nsv904937 CNV Gain 21882294
dgv2522n71 CNV Loss 21882294
dgv2523n71 CNV Loss 21882294
dgv2524n71 CNV Gain+Loss 21882294
nsv904948 CNV Gain 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv904955 CNV Loss 21882294
nsv7274 OTHER Inversion 18451855
nsv904956 CNV Gain 21882294
nsv904957 CNV Loss 21882294
dgv2526n71 CNV Loss 21882294
nsv833117 CNV Loss 17160897
esv1000058 OTHER Inversion 20482838

Relevant External Links for TPSG1 Gene

HapMap Linkage Disequilibrium report

Disorders for TPSG1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TPSG1 Gene in MalaCards »

(1) Disease for TPSG1 Gene

(1) University of Copenhagen DISEASES for TPSG1 Gene

genes like me logo Genes that share disorders with TPSG1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for TPSG1 Gene

Publications for TPSG1 Gene

  1. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. (PMID: 10521469) Wong G.W. … Stevens R.L. (J. Biol. Chem. 1999) 2 3 4 23
  2. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. (PMID: 12194977) Wong G.W. … Stevens R.L. (J. Biol. Chem. 2002) 3 23
  3. Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. (PMID: 10843716) Caughey G.H. … Verghese G.M. (J. Immunol. 2000) 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. New developments in the genetics and activation of mast cell proteases. (PMID: 12217407) Caughey G.H. (Mol. Immunol. 2002) 3

Products for TPSG1 Gene

Sources for TPSG1 Gene

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