TPSG1 Gene
protein-coding GIFtS: 47
GCID: GC16M001271
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tryptase gamma 1
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Aliases
for TPSG1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tryptase Gamma 11 2 | | Mast Cell Tryptase2 | | TMT1 2 3 5 | | Pituitary Tryptase2 | | PRSS311 2 3 | | Skin Tryptase2 | | Serine Protease 312 3 | | TrpA1 | | Transmembrane Tryptase2 3 | | Tryptase Gamma2 | | Gamma I2 | | Tryptase Gamma I2 | | Gamma II2 | | Tryptase Gamma II2 | | Lung Tryptase2 | | EC 3.4.21.-3 | | Mast Cell Protease II2 | | EC 3.4.218 |
Export aliases for TPSG1 gene to outside databasesPrevious GC identifers: GC16M001288 GC16M001212 GC16M001208 GC16M001213 GC16M001204 |
Summaries
for TPSG1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TPSG1:
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors.Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in thiscluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I hasan allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gammaII. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptasespredominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobicdomain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis ofasthma and other allergic and inflammatory disorders. (provided by RefSeq, Jul 2008)
Gene Wiki entry for TPSG1
|
Genomic Views
for TPSG1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TPSG1 gene promoter:
AhR Pax-5 HNF-1 ATF-2 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TPSG1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TPSG1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3TPSG1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M001271: view genomic region
(about GC identifiers)
Start:
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1,271,651 bp from pter |
End:
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1,275,257 bp from pter |
Size:
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3,607 bases |
Orientation:
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minus strand |
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Proteins
for TPSG1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRYG1_HUMAN, Q9NRR2 (See
protein sequence)Recommended Name: Tryptase gamma precursor Size: 321 amino acids; 33815 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q96RZ8 Q9C015 Q9NRQ8 Q9UBB2Explore the universe of human proteins at neXtProt for TPSG1: NX_Q9NRR2
4/5 DME Specific Peptides for TPSG1 (Q9NRR2) (see all 5)
TPSG1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036599.3
ENSEMBL proteins: ENSP00000234798
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TPSG1 for ontologies About GeneDecksing
TPSG1 Antibody Products:
Assay Products for TPSG1: |
Protein
Domains /
Families
for TPSG1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TPSG1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRR2ProtoNet protein and cluster: Q9NRR2 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: TRYG1_HUMAN, Q9NRR2Similarity: Belongs to the peptidase S1 family. Tryptase subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for TPSG1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPSG1 (see all 3)
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- | | GO:0008236 | serine-type peptidase activity |
TAS | 10521469 |
TPSG1 for ontologies About GeneDecksing
|
Pathways & Interactions
for TPSG1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TPSG1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
TPSG1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TPSG1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TPSG1 for compounds About GeneDecksing
 Compounds for TPSG1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| APC 366 | Tryptase inhibitor | [178925-65-0] |
1 Novoseek chemical compound relationship for TPSG1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
53.5 |
7 |
12194977 (1), 16815034 (1), 17498058 (1) |
Search CenterWatch for drugs/clinical trials and news about TPSG1 / TRYG1
|
Transcripts
for TPSG1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TPSG1 gene: NM_012467.3 Unigene Cluster for TPSG1: Tryptase gamma 1 Hs.592076 [show with all ESTs]Unigene Representative Sequence: NM_0124672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000234798(uc002ckw.2) ENST00000564684
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPSG1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPSG1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TPSG1 (NM_012467) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TPSG1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPSG1 |
3 DOTS entries: DT.106240 DT.92423330 DT.95329487 3 AceView cDNA sequences: NM_012467 AF175522 BG953129
GeneLoc Exon Structure
|
Expression
for TPSG1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TPSG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTGTGCCC
About this image
See TPSG1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TPSG1
SOURCE GeneReport for Unigene cluster: Hs.592076
UniProtKB/Swiss-Prot: TRYG1_HUMAN, Q9NRR2Tissue specificity: Expressed in many tissues
SABiosciences Custom PCR Arrays for TPSG1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPSG1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TPSG1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TPSG1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TPSG1 |
Orthologs
for TPSG1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TPSG1 gene from 1/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG111923 |
serine-type endopeptidase |
39(a)
(best of 5) |
|
56F17 -- |
ENSEMBL Gene Tree for TPSG1 (if available)
TreeFam Gene Tree for TPSG1 (if available) |
Paralogs
for TPSG1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TPSG1 gene
- PRSS462 PRSS552 PRSS482 PRSS222 PRSS272 PRSS212 PRSS452 TPSD12
- PRSS382 TPSAB12 PRSS532 PRSS502 PRSS422 PRSS362 PRSS332 KLKB12
- PRSS82 F112 OVCH12
18/74 SIMAP similar genes for TPSG1 using alignment to 2 protein entries: TRYG1_HUMAN (see all proteins)
(see all similar genes):TPSB2 TPSAB1 tryptaseC PRSS22 PRSS45 F12
TMPRSS3 TMPRSS11B TPSD1 CELA2B PRSS27 TMPRSS4
tryptaseB TMPRSS5 CELA3A PRSS33 PRSS1 DKFZp779M0222
TPSG1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TPSG1
PGOHUM00000262310
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Genomic Variants
for TPSG1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: TRYG1_HUMAN, Q9NRR2Polymorphism: There are two alleles; gamma-I and gamma-II which differ by 5 residues
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TPSG1 (1271651 - 1275257 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TPSG1
4 CNVs: 29991 4915 5329 29995
1 Inversion: 37173 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TPSG1 |
|
Disorders
/ Diseases
for TPSG1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TPSG1 for disorders About GeneDecksing
OMIM gene information: 609341
OMIM disorders: --
2  diseases for TPSG1: About MalaCardsasthma breast cancer
Export disorders for TPSG1 gene to outside databases
|
Publications
for TPSG1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TPSG1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TPSG1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. (PubMed id 10521469)1, 2, 3, 9 Wong G.W.... Stevens R.L. (1999)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families. (PubMed id 10843716)1, 2 Caughey G.H.... Verghese G.M. (2000)
- Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. (PubMed id 12194977)1, 9 Wong G.W....Stevens R.L. (2002)
- Mast cell tryptase promotes breast cancer migration a nd invasion. (PubMed id 20126998)1 Xiang M....Yin L. (2010)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- New developments in the genetics and activation of mast cell proteases. (PubMed id 12217407)1 Caughey G.H. (2002)
- Cloning of the human homolog of mouse transmembrane tryptase. (PubMed id 10224463)9 Wong G.W....Stevens R.L. (1999)
- Expression and characterization of recombinant gamma-tryptase. (PubMed id 16815034)9 Yuan J....Clark J.M. (2006)
- Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity. (PubMed id 17498058)9 Stevens R.L. and Adachi R. (2007)
|
External Searches for TPSG1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TPSG1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TPSG1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TPSG1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TPSG1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TPSG1 gene:
Search GeneIP for patents involving TPSG1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TPSG1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TPSG1 | | OriGene shRNA RFP for TPSG1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TPSG1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TPSG1 | | | OriGene Protein Over-expression Lysate for TPSG1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TPSG1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TPSG1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TPSG1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TPSG1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | TPSG1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TPSG1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TPSG1 |
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