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Aliases for TPSD1 Gene

Aliases for TPSD1 Gene

  • Tryptase Delta 1 2 3
  • HmMCP-3-Like Tryptase III 3 4
  • Delta-Tryptase 3 4
  • EC 4 63
  • Tryptase-3 3 4
  • MCP7L1 3 6
  • MMCP-7-Like Delta II Tryptase 3
  • Mast Cell MMCP-7-Like 4
  • Mast Cell Tryptase 3
  • MMCP-7-Like II 2
  • Tryptase Delta 3
  • MMCP-7-Like I 2
  • MMCP-7-LIKE-2 2
  • MMCP-7-Like-1 3
  • MMCP-7-Like-2 3
  • MCP7-LIKE 3
  • EC 3.4.21 63
  • MMCP-7L 3

External Ids for TPSD1 Gene

Previous GeneCards Identifiers for TPSD1 Gene

  • GC16P001322
  • GC16P001246
  • GC16P001235
  • GC16P001307

Summaries for TPSD1 Gene

Entrez Gene Summary for TPSD1 Gene

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPSD1 Gene

TPSD1 (Tryptase Delta 1) is a Protein Coding gene. Diseases associated with TPSD1 include asthma. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for TPSD1 Gene

  • Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

Gene Wiki entry for TPSD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSD1 Gene

Genomics for TPSD1 Gene

Regulatory Elements for TPSD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TPSD1 Gene

1,256,059 bp from pter
1,258,998 bp from pter
2,940 bases
Plus strand

Genomic View for TPSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPSD1 Gene

Proteins for TPSD1 Gene

  • Protein details for TPSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tryptase delta
    Protein Accession:
    Secondary Accessions:
    • O95824
    • Q8TDI6
    • Q96L36
    • Q96RZ5
    • Q9H2Y6
    • Q9UQI8

    Protein attributes for TPSD1 Gene

    242 amino acids
    Molecular mass:
    26584 Da
    Quaternary structure:
    • Homotetramer.
    • Sequence=AAD17861.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK12909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPSD1 Gene


neXtProt entry for TPSD1 Gene

Proteomics data for TPSD1 Gene at MOPED

Post-translational modifications for TPSD1 Gene

  • Glycosylation at Asn139
  • Modification sites at PhosphoSitePlus

Other Protein References for TPSD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TPSD1 Gene

Suggested Antigen Peptide Sequences for TPSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZJ3
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Tryptase subfamily.
genes like me logo Genes that share domains with TPSD1: view

No data available for Gene Families for TPSD1 Gene

Function for TPSD1 Gene

Molecular function for TPSD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa, but with more restricted specificity than trypsin.
UniProtKB/Swiss-Prot Function:
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.

Enzyme Numbers (IUBMB) for TPSD1 Gene

Gene Ontology (GO) - Molecular Function for TPSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS 9920877
genes like me logo Genes that share ontologies with TPSD1: view

Animal Model Products

CRISPR Products

miRNA for TPSD1 Gene

miRTarBase miRNAs that target TPSD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSD1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TPSD1 Gene

Localization for TPSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPSD1 Gene

Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TPSD1 Gene COMPARTMENTS Subcellular localization image for TPSD1 gene
Compartment Confidence
extracellular 3
lysosome 2
vacuole 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TPSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TPSD1: view

Pathways for TPSD1 Gene

SuperPathways for TPSD1 Gene

No Data Available

Interacting Proteins for TPSD1 Gene

Gene Ontology (GO) - Biological Process for TPSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TPSD1: view

No data available for Pathways by source for TPSD1 Gene

Compounds for TPSD1 Gene

(2) HMDB Compounds for TPSD1 Gene

Compound Synonyms Cas Number PubMed IDs
Kinetensin 1-3
  • Ile-Ala-Arg
Not Available
Kinetensin 4-8
  • KT(4-8)
genes like me logo Genes that share compounds with TPSD1: view

Transcripts for TPSD1 Gene

mRNA/cDNA for TPSD1 Gene

Unigene Clusters for TPSD1 Gene

Tryptase delta 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSD1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPSD1 Gene

No ASD Table

Relevant External Links for TPSD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPSD1 Gene

mRNA expression in normal human tissues for TPSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPSD1 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.6) and Esophagus - Muscularis (4.6).

Protein differential expression in normal tissues for TPSD1 Gene

This gene is overexpressed in Skin (38.5) and Lung (30.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TPSD1 Gene

SOURCE GeneReport for Unigene cluster for TPSD1 Gene Hs.677789

mRNA Expression by UniProt/SwissProt for TPSD1 Gene

Tissue specificity: Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells.
genes like me logo Genes that share expressions with TPSD1: view

Expression partners for TPSD1 Gene

In Situ Assay Products

Orthologs for TPSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TPSD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPSD1 35
  • 92.61 (n)
  • 86.32 (a)
-- 36
  • 42 (a)
(Bos Taurus)
Mammalia TPSB1 36
  • 60 (a)
TPSB1 36
  • 60 (a)
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
-- 36
  • 43 (a)
-- 36
  • 39 (a)
-- 36
  • 33 (a)
(Mus musculus)
Mammalia Tpsab1 36
  • 53 (a)
Tpsb2 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
-- 36
  • 37 (a)
-- 36
  • 34 (a)
-- 36
  • 29 (a)
-- 36
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 31 (a)
Species with no ortholog for TPSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPSD1 Gene

Gene Tree for TPSD1 (if available)
Gene Tree for TPSD1 (if available)

Paralogs for TPSD1 Gene

genes like me logo Genes that share paralogs with TPSD1: view

Variants for TPSD1 Gene

Sequence variations from dbSNP and Humsavar for TPSD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1060280 -- 1,256,550(+) ATTGT(C/T)GGGGG synonymous-codon, reference
rs1060282 -- 1,256,612(+) CGGCC(C/G)ATACT reference, missense
rs1064772 -- 1,256,544(+) ACGGG(C/T)ATTGT reference, synonymous-codon
rs1141966 -- 1,256,670(+) ACCGC(A/G)GCGCA synonymous-codon, reference
rs1141967 -- 1,256,680(+) ACTGC(A/C/G)TGGAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TPSD1 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2514n71 CNV Loss 21882294
dgv2520n71 CNV Loss 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv904955 CNV Loss 21882294
nsv7274 OTHER Inversion 18451855
nsv904957 CNV Loss 21882294
nsv833117 CNV Loss 17160897
esv1000058 OTHER Inversion 20482838
nsv1708 CNV Loss 18451855
esv2750310 CNV Deletion 23290073
nsv523308 CNV Loss 19592680
nsv904962 CNV Gain 21882294
nsv904963 CNV Gain+Loss 21882294
dgv2527n71 CNV Loss 21882294
nsv103222 CNV Loss 16902084
nsv515770 CNV Loss 19592680

Relevant External Links for TPSD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPSD1 Gene

Disorders for TPSD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TPSD1 Gene in MalaCards »

(1) Diseases for TPSD1 Gene including...

genes like me logo Genes that share disorders with TPSD1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TPSD1 Gene

Publications for TPSD1 Gene

  1. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. (PMID: 9920877) Pallaoro M. … Caughey G.H. (J. Biol. Chem. 1999) 2 3 4
  2. Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity. (PMID: 12391231) Wang H.-W. … Hunt J.E. (J. Immunol. 2002) 3 4 23
  3. Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. (PMID: 18325577) Trivedi N.N. … Caughey G.H. (J. Allergy Clin. Immunol. 2008) 3 23
  4. Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation. (PMID: 18854315) Jackson N.E. … Hunt J.E. (J. Biol. Chem. 2008) 3 4
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4

Products for TPSD1 Gene

Sources for TPSD1 Gene

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