Aliases for TPSB2 Gene
Aliases for TPSB2 Gene
External Ids for TPSB2 Gene
- HGNC: 14120
- Entrez Gene: 64499
- Ensembl: ENSG00000197253
- OMIM: 191081
- UniProtKB: P20231
Previous GeneCards Identifiers for TPSB2 Gene
- GC16U990168
- GC16P001231
- GC16P001191
- GC16P001234
- GC16M001219
- GC16M001278
- GC16M001279
- GC16M001280
- GC16M001281
Summaries for TPSB2 Gene
-
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
GeneCards Summary for TPSB2 Gene
TPSB2 (Tryptase Beta 2 (Gene/Pseudogene)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.
UniProtKB/Swiss-Prot for TPSB2 Gene
-
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
Additional gene information for TPSB2 Gene
- Monarch Initiative
- Search for TPSB2 at DataMed
- Search for TPSB2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSB2 Gene
Genomics for TPSB2 Gene
GeneHancer (GH) Regulatory Elements for TPSB2 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16I001230 | Promoter | 0.5 | EPDnew | 550.8 | 0.0 | -20 | 0.1 | TPSB2 TPSAB1 LOC102723999 | ||
GH16I001244 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 38.3 | -15.2 | -15239 | 1.1 | ZNF316 MAFG NFE2 EMSY GABPA | TPSD1 TPSAB1 TPSB2 TPSG1 LOC105379540 | |
GH16I001167 | Enhancer | 0.8 | ENCODE dbSUPER | 7.5 | +60.9 | 60862 | 2.8 | RING1 KLF1 HIC1 ZFHX2 ZFP36 ZBTB33 KLF8 EGR2 ZBTB20 | LUC7L IFT140 TSC2 WDR90 CRAMP1 ENSG00000260447 WDR24 NME3 CCDC154 TELO2 | |
GH16I001225 | Promoter/Enhancer | 0.9 | EPDnew ENCODE | 6.4 | +4.7 | 4748 | 0.8 | POLR2A HNF4A ZIC2 | TPSG1 ENSG00000277010 TPSB2 GC16P001224 LOC102723999 | |
GH16I000536 | Enhancer | 0.4 | dbSUPER | 6 | +693.0 | 692997 | 1.1 | CTCF KLF1 | MIR5587 CAPN15 PRR35 NHLRC4 PIGQ TPSB2 MIR3176 |
Regulatory Element Products
Genomic Locations for TPSB2 Gene
- chr16:1,227,272-1,230,184
- (GRCh38/hg38)
- Size:
- 2,913 bases
- Orientation:
- Minus strand
- chr16:1,277,272-1,280,214
- (GRCh37/hg19)
Genomic View for TPSB2 Gene
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC


RefSeq DNA sequence for TPSB2 Gene
Proteins for TPSB2 Gene
-
Protein details for TPSB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20231-TRYB2_HUMAN
- Recommended name:
- Tryptase beta-2
- Protein Accession:
- P20231
- D2E6S0
- D2E6S2
- O95827
- Q15664
- Q9UQI6
- Q9UQI7
Protein attributes for TPSB2 Gene
- Size:
- 275 amino acids
- Molecular mass:
- 30515 Da
- Quaternary structure:
-
- Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.
Protein Expression for TPSB2 Gene
Selected DME Specific Peptides for TPSB2 Gene
- P20231:
-
- CWVTGWGDVDN
- DIALLEL
- VLTAAHC
- SWGEGCA
- GDSGGPL
- LPPASETFP
- QRVGIVGG
- PLKQVKVPI
- EQHLYYQD
- SGGPLVC
- FCGGSLI
- VSRIIVHP
- DSCQGDSGG
- CWVTGWG
- HFCGGSL
- CQGDSGGP
- WVLTAAH
- WPWQVSL
Post-translational modifications for TPSB2 Gene
- Glycosylation at isoforms=233
Other Protein References for TPSB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TPSB2 (Tryptase beta-2/TPSB2)
- Novus Biologicals Antibodies for TPSB2
-
Cloud-Clone Corp. Antibodies for TPSB2
- Invitrogen Antibodies for TPSB2
- Search GeneTex for Antibodies for TPSB2
- Sino Biological Antibodies for TPSB2
Protein Products
- R&D Systems Proteins and Enzymes for TPSB2 (Tryptase beta-2/TPSB2)
-
OriGene Purified Proteins for TPSB2
- Search Origene for MassSpec and Protein Over-expression Lysates for TPSB2
- Origene Custom Protein Services for TPSB2
- Novus Biologicals lysates for TPSB2
-
Cloud-Clone Corp. Proteins for TPSB2
- Search GeneTex for Proteins for TPSB2
-
ProSci Proteins for TPSB2
Assay Products
-
Cloud-Clone Corp. Assay Kits for TPSB2
Domains & Families for TPSB2 Gene
Gene Families for TPSB2 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted secreted proteins
Protein Domains for TPSB2 Gene
Suggested Antigen Peptide Sequences for TPSB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20231- Family:
-
- Belongs to the peptidase S1 family. Tryptase subfamily.
Function for TPSB2 Gene
Molecular function for TPSB2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Preferential cleavage: Arg- -Xaa, Lys- -Xaa, but with more restricted specificity than trypsin.
- UniProtKB/Swiss-Prot Function:
- Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
Enzyme Numbers (IUBMB) for TPSB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004252 | serine-type endopeptidase activity | NAS | 9920877 |
GO:0005515 | protein binding | IPI | 14670919 |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008236 | serine-type peptidase activity | TAS,IEA | 2203827 |
GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for TPSB2 Gene
- MGI mutant phenotypes for TPSB2:
- inferred from 2 alleles
Animal Models for TPSB2 Gene
- MGI Knock Outs for TPSB2:
-
- Tpsb2 tm1.1Mfg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TPSB2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TPSB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TPSB2 gene
- Search ViGene Biosciences for TPSB2
CRISPR Products
-
OriGene CRISPR knockouts for TPSB2
- genomics-online: gRNA clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for TPSB2
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for TPSB2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPSB2
- Browse OriGene Inhibitory RNA Products For TPSB2
- genomics-online: shRNA clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for TPSB2 gene
Clone Products
- Sino Biological Human cDNA Clone for TPSB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TPSB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPSB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for TPSB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TPSB2
-
ViGene Biosciences adenoviral particle packaged cDNA for TPSB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TPSB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TPSB2 gene
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TPSB2 Gene
Localization for TPSB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TPSB2 Gene
- Secreted. Note=Released from the secretory granules upon mast cell activation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0031012 | extracellular matrix | IDA | 27559042 |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TPSB2 Gene
Pathways & Interactions for TPSB2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TPSB2 Gene
Drugs & Compounds for TPSB2 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
(5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone | Experimental | Pharma | Target | 0 | ||
[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE | Experimental | Pharma | Target | 0 | ||
4-PIPERIDIN-4-YLBUTANAL | Experimental | Pharma | Target | 0 | ||
Amido Phenyl Pyruvic Acid | Experimental | Pharma | Target | 0 |
Transcripts for TPSB2 Gene
mRNA/cDNA for TPSB2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (82) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TPSB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TPSB2
- genomics-online: gRNA clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials CRISPR for TPSB2
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
- Search ViGene Biosciences for TPSB2
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TPSB2
- Browse OriGene Inhibitory RNA Products For TPSB2
- genomics-online: shRNA clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
-
ViGene Biosciences ready-to-package AAV shRNAs for TPSB2 gene
Clone Products
- Sino Biological Human cDNA Clone for TPSB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TPSB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TPSB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- orf clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- Applied Biological Materials Clones for TPSB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TPSB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for TPSB2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TPSB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TPSB2 Gene:
TPSB2SOURCE GeneReport for Unigene cluster for TPSB2 Gene:
Hs.592982Primer Products
-
OriGene qPCR primer pairs and template standards for TPSB2
-
OriGene qPCR primer pairs for TPSB2
- genomics-online: primer clones - Search results for 83 available TPSB2 gene related products
- Overview of 83 available TPSB2 gene related products
-
Recommended
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
- pPB-His-GST
- pPB-His-MBP
- pPB-N-His
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pDONR223
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL5
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPSB2 Gene
Orthologs for TPSB2 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TPSB2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | LOC786948 33 |
|
||
TPSB1 34 34 |
|
ManyToMany | |||
dog (Canis familiaris) |
Mammalia | LOC100049001 33 |
|
||
-- 34 |
|
OneToMany | |||
mouse (Mus musculus) |
Mammalia | Tpsb2 33 16 34 |
|
||
Tpsab1 34 |
|
ManyToMany | |||
rat (Rattus norvegicus) |
Mammalia | Tpsb2 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | CG18735 35 |
|
|
|
CG7432 35 |
|
|
- Species where no ortholog for TPSB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for TPSB2 Gene
(100) SIMAP similar genes for TPSB2 Gene using alignment to 4 proteins:
- tryptaseB
- tryptaseC
- TPSAB1
- TPSD1
- MGC52282
- F12
- TPSG1
- PRSS29P
- PRSS22
- PRSS45
- PRSS27
- DKFZp586F0824
- CELA3A
- PRSS42
- PRSS36
- F2
- CELA2A
- ELA2A
- TMPRSS11D
- PRSS8
- CELA2B
- TMPRSS5
- KLKB1
- CELA1
- ELA3A
- KLK13
- OVCH1
- PRSS44
- DKFZp779M0222
- TMPRSS15
- F11
- HP
- TMPRSS2
- PRSS33
- KLK4
- CTRL
- ELA2B
- PRSS41
- PRSS1
- UNQ9391
- TMPRSS7
- TMPRSS3
- CELA3B
- KLK9
- TMPRSS13
- TMPRSS11B
- PRSS21
- PROC1
- PRSS48
- F9 p22
- serase-1B
- factor IX F9
- TMPRSS9
- TMPRSS6
- TMPRSS4
- PROC
- HABP2
- CTRB1
- CTRB2
- KLK8
- CTRC
- C1R
- GZMH
- GZMA
- ST14
- PRSS55
- PRSS50
- ACR
- PRSS46
- GZMK
- CTSG
- KLK2
- CORIN
- F9
- F7
- TMPRSS12
- TRY8
- TMPRSS11E
- PRSS47
- LPA
- PRSS58
- GZMM
- KLK15
- PRSS2
- PRSS56
- TMPRSS11A
- CMA1
- TMPRSS11F
- PRSS57
- PRSS12
- DESC1
- KLK6
- GZMB
- KLK12
- KLK14
- DF
- PRSS3
- PRSS53
- HPN
- APS
Pseudogenes.org Pseudogenes for TPSB2 Gene
Variants for TPSB2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TPSB2 Gene
- TRYB2_HUMAN-P20231
- There are two alleles; beta-II and beta-III. Beta-II is the most commun allele. There are two forms of the beta-III allele, a short and a long form. The short form (also named frameshifted form) is carried by 23% and 19% of individuals of European and African ancestry but 0% of Asian subjects. In the human genome reference version GRCh37/hg19, the allele beta-III short form is represented.
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs199887053 | benign, not specified | 1,229,573(-) | C/G/T | coding_sequence_variant, missense_variant | |
rs201836020 | benign, not specified | 1,229,731(-) | C/A/T | coding_sequence_variant, missense_variant | |
rs1003156276 | -- | 1,230,347(-) | C/T | upstream_transcript_variant | |
rs1005083949 | -- | 1,231,552(-) | C/T | upstream_transcript_variant | |
rs1007236882 | -- | 1,228,387(-) | C/T | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2691n100 | CNV | gain | 25217958 |
dgv2692n100 | CNV | gain | 25217958 |
esv1000058 | OTHER | inversion | 20482838 |
esv2422427 | CNV | duplication | 17116639 |
esv2750305 | CNV | deletion | 23290073 |
esv29040 | CNV | loss | 19812545 |
esv3892754 | CNV | loss | 25118596 |
nsv1046885 | CNV | gain | 25217958 |
nsv1051302 | CNV | gain | 25217958 |
nsv1708 | CNV | deletion | 18451855 |
nsv428316 | CNV | gain+loss | 18775914 |
nsv471066 | CNV | loss | 18288195 |
nsv571101 | CNV | gain | 21841781 |
nsv571102 | CNV | loss | 21841781 |
nsv571105 | CNV | loss | 21841781 |
nsv571108 | CNV | loss | 21841781 |
nsv571109 | CNV | gain | 21841781 |
nsv7274 | OTHER | inversion | 18451855 |
nsv833117 | CNV | loss | 17160897 |
nsv952899 | CNV | deletion | 24416366 |
nsv984247 | CNV | duplication | 23825009 |
Additional Variant Information for TPSB2 Gene
No data available for Variation tolerance for TPSB2 Gene
Disorders for TPSB2 Gene
Additional Disease Information for TPSB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TPSB2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPSB2 Gene
Publications for TPSB2 Gene
- Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. (PMID: 19748655) Trivedi NN … Caughey GH (The Journal of allergy and clinical immunology 2009) 2 3 4 44 58
- Active monomers of human beta-tryptase have expanded substrate specificities. (PMID: 18039527) Fukuoka Y … Schwartz LB (International immunopharmacology 2007) 4 22 58
- Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. (PMID: 14670919) Strik MC … Kummer JA (Blood 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. (PMID: 10898108) Guida M … Hall J (Pharmacogenetics 2000) 3 22 58
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- Mammalian expression: PiggyBac
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- Yeast expression
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- pLenti-U6-sgRNA-PGK-Neo
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- pPB-N-His
- pPB-His-MBP
- pPB-His-GST
Sources for TPSB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (30) GeneAnnot
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- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
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- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
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- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (155) genomics-online
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