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TPSB2 Gene

protein-coding   GIFtS: 53
GCID: GC16M001281

Tryptase Beta 2 (Gene/Pseudogene)

(Previous name: tryptase beta 2)
  See related diseases
at
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Aliases
for TPSB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tryptase Beta 2 (Gene/Pseudogene)1 2     Mast Cell Tryptase Beta III2
TPS22 3 5     Tryptase Beta-22
EC 3.4.21.593 8     tryptaseB2
Tryptase Beta 21     tryptaseC2
Tryptase Beta II1     Tryptase-23
Tryptase Beta III1     Tryptase II3
Mast Cell Tryptase Beta II2     EC 3.4.218

External Ids:    HGNC: 141201   Entrez Gene: 644992   Ensembl: ENSG000001972537   OMIM: 1910815   UniProtKB: P202313   

Export aliases for TPSB2 gene to outside databases

Previous GC identifers: GC16U990168 GC16P001231 GC16P001191 GC16P001234 GC16M001219 GC16M001278 GC16M001279 GC16M001280


Summaries
for TPSB2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TPSB2 Gene:
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase
inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several
distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3'
UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately
upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding
sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene
exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two
separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells,
whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the
pathogenesis of asthma and other allergic and inflammatory disorders. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPSB2 Gene:
TPSB2 (tryptase beta 2 (gene/pseudogene)) is a protein-coding gene. Diseases associated with TPSB2 include dermatitis herpetiformis, and asthma. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231
Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled
activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection.
Required to efficiently combat K.pneumoniae infection (By similarity)

Gene Wiki entry for TPSB2 Gene


Genomic Views
for TPSB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TPSB2 gene promoter:
         AhR   Pax-5   HNF-1   ATF-2   HNF-1A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TPSB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPSB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

TPSB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPSB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001281:  view genomic region     (about GC identifiers)

Start:
 1,277,272 bp from pter      End:
 1,280,214 bp from pter
Size:
 2,943 bases      Orientation:
 minus strand

Proteins
for TPSB2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231 (See protein sequence)
Recommended Name: Tryptase beta-2 precursor  
Size: 275 amino acids; 30515 Da
Subunit: Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the
absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of
heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active
tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the
hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for
macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the
tetrameric form. The monomeric form forms a complex with SERPINB6
Selected PDB 3D structures from and Proteopedia for TPSB2 (see all 11):
1A0L (3D)        1AAO (3D)        2BM2 (3D)        2FPZ (3D)        2FS8 (3D)        2FS9 (3D)    
Secondary accessions: D2E6S0 D2E6S2 O95827 Q15664 Q9UQI6 Q9UQI7

Explore the universe of human proteins at neXtProt for TPSB2: NX_P20231

Explore proteomics data for TPSB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
    • Selected DME Specific Peptides for TPSB2 (P20231) (see all 18)
     DIALLEL  VLTAAHC  WVLTAAH  CWVTGWG 


    See TPSB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077078.5  
    ENSEMBL proteins: 
     ENSP00000426256   ENSP00000412409  

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    Sino Biological Recombinant Protein for TPSB2
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TPSB2 Antibody Products:

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    TPSB2 Assay Products:

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    Domains /
    Families
    for TPSB2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    TryGeneCards Plus    		 4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR009003 Trypsin-like_Pept_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry P20231

    ProtoNet protein and cluster: P20231

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231
    Similarity: Belongs to the peptidase S1 family. Tryptase subfamily
    Similarity: Contains 1 peptidase S1 domain


    TPSB2 for domains           About GeneDecksing


    Function
    for TPSB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRYB2_HUMAN, P20231
    Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled
    activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection.
    Required to efficiently combat K.pneumoniae infection (By similarity)
    Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa, but with more restricted specificity than trypsin

         Enzyme Numbers (IUBMB): EC 3.4.21.591 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity NAS9920877
    GO:0008236serine-type peptidase activity TAS2203827
         
    TPSB2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tpsb2):
     cellular  hematopoietic system  immune system  skeleton 

    TPSB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tpsb2tm1.1Mfg for TPSB2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TPSB2
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    In Situ Assay
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    Localization
    for TPSB2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRYB2_HUMAN, P20231: Secreted. Note=Released from the secretory granules upon mast cell activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

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    Pathways & Interactions
    for TPSB2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TPSB2
    Interactions:

        GeneGlobe Interaction Network for TPSB2

    3 Interacting proteins for TPSB2 (P202313) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163333I2D: score=1 
    PIK3R1P279863I2D: score=1 
    TPSAB1Q156613I2D: score=1 
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

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    Drugs & Compounds
    for TPSB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TPSB2 (TRYB2)

    2 HMDB Compounds for TPSB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Kinetensin 1-3Ile-Ala-Arg;KT(1-3) ----
    Kinetensin 4-8KT(4-8);Arg-His-Pro-Tyr-Phe 51833-69-3--

    4 DrugBank Compounds for TPSB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Amido Phenyl Pyruvic Acid-- --target--17139284 17016423
    (5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone-- --target--10592235
    [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE-- --target--10592235
    4-PIPERIDIN-4-YLBUTANAL-- --target----

    1 Novoseek inferred chemical compound relationship for TPSB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 49.8 2 8039831 (1), 18039527 (1)



    TPSB2 for compounds           About GeneDecksing



    Transcripts
    for TPSB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TPSB2 gene: 
    NM_024164.5  

    Unigene Cluster for TPSB2:

    Tryptase beta 2 (gene/pseudogene)
    Hs.592982  [show with all ESTs]
    Unigene Representative Sequence: BC065923
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339687(uc010brk.1) ENST00000606293 ENST00000445910 ENST00000430512(uc002ckx.3 uc002cky.3)

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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TPSB2
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    Additional mRNA sequence: 

    AK308208.1 BC029356.1 BC065923.1 FJ931119.1 FJ931120.1 M33492.1 M37488.1 S55551.1 

    3 DOTS entries:

    DT.446428  DT.100749578  DT.75138719 

    Selected AceView cDNA sequences (see all 82):

    AA887888 AI581938 BQ719498 BF876081 BV200561 BQ082929 BM991728 M33493 
    BM989945 BQ003361 CA867461 BV200560 BU787858 BM663927 BV207479 BV185679 
    BI819421 AI832733 BV207482 AI678487 BV207480 AI610847 CD672689 BV201257 

    GeneLoc Exon Structure


    Expression
    for TPSB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TPSB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TPSB2 Expression
    About this image


    TPSB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Pharynx
     
     Lung (Respiratory System)
     
     Dermis (Integumentary System)
    TPSB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    TPSB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592982
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    Orthologs
    for TPSB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TPSB2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tpsb21 , 5 tryptase beta 21, 5 77.35(n)1
    78.38(a)1    		   17 (12.53 cM)5
    172291  NM_010781.31  NP_034911.31 
     253665505 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 Uncharacterized protein
    		 39(a)
    33(a)
    		 many ↔ many
    many ↔ many
    		 GL343253.1(1843088-1847017)
    GL343287.1(1454751-1470659)


    ENSEMBL Gene Tree for TPSB2 (if available)
    TreeFam Gene Tree for TPSB2 (if available)

    Paralogs
    for TPSB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TPSB2 gene
    TPSAB11 2  PRSS462  PRSS482  PRSS222  PRSS272  TMPRSS92  PRSS212  PRSS452  
    TPSG12  TPSD12  PRSS382  PRSS532  PRSS502  PRSS422  PRSS362  PRSS332  
    PRSS82  
    Selected SIMAP similar genes for TPSB2 using alignment to 4 protein entries:     TRYB2_HUMAN (see all proteins) (see all similar genes):
    tryptaseB    tryptaseC    TPSAB1    TPSD1    MGC52282    F12
    TPSG1    PRSS29P    PRSS22    DKFZp586F0824    PRSS27    PRSS45
    CELA3A    CELA2A    F2    PRSS36    PRSS42    ELA2A

    TPSB2 for paralogs           About GeneDecksing



    Genomic Variants
    for TPSB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TRYB2_HUMAN, P20231: There are two alleles; beta-II and beta-III. Beta-II is the most commun allele. There are two forms
    of the beta-III allele, a short and a long form. The short form (also named frameshifted form) is carried by 23%
    and 19% of individuals of European and African ancestry but 0% of Asian subjects. In the human genome reference
    version GRCh37/hg19, the allele beta-III short form is represented


    Selected SNPs for TPSB2 (see all 139)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2001300571,2
    		C--1277888(+) GAGTT-/CAAGGC 1 -- ds50010--------
    rs1391958211,2
    		--1277991(+) TGGACA/GGAGGG 1 -- ds50010--------
    rs1858040801,2
    		--1277999(+) GGGGCA/CGGGAG 1 -- ds50010--------
    rs1432063541,2
    		--1278000(+) GGGCCA/GGGAGA 1 -- ds50010--------
    rs559808461,2
    		C--1278037(+) GGCTCA/GTGATG 1 -- ds50010--------
    rs758414891,2
    		C,F--1278063(+) CCCGGC/TGACCA 1 -- ds50012Minor allele frequency- T:0.25NA 8
    rs3750691221,2
    		C--1278183(+) CAGCCC/TGGGGA 1 -- ds50010--------
    rs10603441,2
    		F--1278414(-) CCTCCG/AGCCCT 1 -- ut311Minor allele frequency- A:0.37MN 184
    rs10603411,2
    		C,F--1278424(+) GGCCCA/GGTGCA 1 -- ut3112Minor allele frequency- G:0.48EA NA MN WA CSA 601
    rs1831323051,2
    		C--1278457(+) AGGGGA/GCTCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TPSB2 (1277272 - 1280214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TPSB2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750305CNV Deletion23290073
    esv2422427CNV Duplication17116639
    nsv833117CNV Loss17160897
    nsv904954CNV Loss21882294
    esv29040CNV Loss19812545
    nsv904950CNV Loss21882294
    dgv2522n71CNV Loss21882294
    nsv471066CNV Loss18288195
    dgv2505n71CNV Loss21882294
    dgv2514n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TPSB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TPSB2
    DNA2.0 Custom Variant and Variant Library Synthesis for TPSB2

    Disorders / Diseases
    for TPSB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 191081    OMIM disorders: --

    5 diseases for TPSB2:    
    About MalaCards
    dermatitis herpetiformis    asthma    mastocytosis    pneumonia
    dermatitis

    1 disease from the University of Copenhagen DISEASES database for TPSB2:
    Dermatitis herpetiformis

    TPSB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TPSB2
    Human Genome Epidemiology (HuGE) Navigator: TPSB2 (1 document)

    Export disorders for TPSB2 gene to outside databases

    Publications
    for TPSB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TPSB2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with TPSB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. (PubMed id 19748655)1, 2, 3, 4 Trivedi N.N.... Caughey G.H. (J. Allergy Clin. Immunol. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. (PubMed id 9920877)1, 2 Pallaoro M.... Caughey G.H. (J. Biol. Chem. 1999)
    4. The structure of the human betaII-tryptase tetramer: fo(u)r better or worse. (PubMed id 10500112)1, 2 Sommerhoff C.P.... Bergner A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    5. Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. (PubMed id 9521329)1, 2 Pereira P.J.B.... Bode W. (Nature 1998)
    6. Characterization of a tryptase mRNA expressed in the human basophil cell line KU812. (PubMed id 8434231)1, 2 Blom T. and Hellman L. (Scand. J. Immunol. 1993)
    7. Cloning and characterization of a second complementary DNA for human tryptase. (PubMed id 2203827)1, 2 Miller J.S.... Schwartz L.B. (J. Clin. Invest. 1990)
    8. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. (PubMed id 2187193)1, 2 Vanderslice P....Caughey G.H. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    9. Active monomers of human beta-tryptase have expanded substrate specificities. (PubMed id 18039527)2, 9 Fukuoka Y. and Schwartz L.B. (Int. Immunopharmacol. 2007)
    10. Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. (PubMed id 10898108)1, 9 Guida M.... Hall J. (Pharmacogenetics 2000)

    External Searches for TPSB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing TPSB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64499 HGNC: 14120 AceView: TPS1.1 Ensembl:ENSG00000197253 euGenes: HUgn64499
    ECgene: TPSB2 H-InvDB: TPSB2

    Other Databases showing TPSB2 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing TPSB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TPSB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TPSB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for TPSB2 gene:
    Search GeneIP for patents involving TPSB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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