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TPSB2 Gene

protein-coding GIFtS: 53
GCID: GC16M001281

Tryptase Beta 2 (Gene/Pseudogene)

(Previous name: tryptase beta 2)

See TPSB2-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tryptase Beta 2 (Gene/Pseudogene)¹ ²		Mast Cell Tryptase Beta III²
TPS2² ³ ⁵		Tryptase Beta-2²
EC 3.4.21.59³ ⁸		tryptaseB²
Tryptase Beta 2¹		tryptaseC²
Tryptase Beta II¹		Tryptase-2³
Tryptase Beta III¹		Tryptase II³
Mast Cell Tryptase Beta II²		EC 3.4.21⁸

External Ids:	HGNC: 14120¹	Entrez Gene: 64499²	Ensembl: ENSG00000197253⁷	OMIM: 191081⁵	UniProtKB: P20231³

Export aliases for TPSB2 gene to outside databases

Previous GC identifers: GC16U990168 GC16P001231 GC16P001191 GC16P001234 GC16M001219 GC16M001278 GC16M001279 GC16M001280

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPSB2 Gene:

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically

active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase

inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several

distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3'

UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately

upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding

sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene

exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two

separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells,

whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the

pathogenesis of asthma and other allergic and inflammatory disorders. (provided by RefSeq, Jul 2008)

GeneCards Summary for TPSB2 Gene:

TPSB2 (tryptase beta 2 (gene/pseudogene)) is a protein-coding gene. Diseases associated with TPSB2 include asthma. GO annotations related to this gene include serine-type peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PRSS46.

UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231

Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled

activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection.

Required to efficiently combat K.pneumoniae infection (By similarity)

Gene Wiki entry for TPSB2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000016.9 NC_018927.2 NT_010393.17

Regulatory elements:

Regulatory transcription factor binding sites in the TPSB2 gene promoter:
AhR Pax-5 HNF-1 ATF-2 HNF-1A
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for TPSB2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TPSB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

TPSB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPSB2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M001281: view genomic region (about GC identifiers)

Start:	1,277,272 bp from pter	End:	1,280,214 bp from pter
Size:	2,943 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231 (See protein sequence)

Recommended Name: Tryptase beta-2 precursor

Size: 275 amino acids; 30515 Da

Subunit: Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the

absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of

heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active

tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the

hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for

macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the

tetrameric form. The monomeric form forms a complex with SERPINB6

Selected PDB 3D structures from and Proteopedia for TPSB2 (see all 11):

1A0L (3D)

1AAO (3D)

2BM2 (3D)

2FPZ (3D)

2FS8 (3D)

2FS9 (3D)

Secondary accessions: D2E6S0 D2E6S2 O95827 Q15664 Q9UQI6 Q9UQI7

Explore the universe of human proteins at neXtProt for TPSB2: NX_P20231

Explore proteomics data for TPSB2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for TPSB2 (P20231) (see all 18)

DIALLEL

VLTAAHC

WVLTAAH

CWVTGWG

See TPSB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_077078.5

ENSEMBL proteins:

ENSP00000426256 ENSP00000412409

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	antibodies-online proteins for TPSB2 (8 products)
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	antibodies-online kits for TPSB2 (7 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

4 InterPro protein domains:

IPR001314 Peptidase_S1A

IPR009003 Trypsin-like_Pept_dom

IPR001254 Peptidase_S1

IPR018114 Peptidase_S1_AS

Graphical View of Domain Structure for InterPro Entry P20231

ProtoNet protein and cluster: P20231

2 Blocks protein domains:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: TRYB2_HUMAN, P20231

Similarity: Belongs to the peptidase S1 family. Tryptase subfamily

Similarity: Contains 1 peptidase S1 domain

Find genes that share domains with TPSB2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TRYB2_HUMAN, P20231

Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled

activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection.

Required to efficiently combat K.pneumoniae infection (By similarity)

Catalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa, but with more restricted specificity than trypsin

Enzyme Numbers (IUBMB): EC 3.4.21.59¹ ² EC 3.4.21²

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	NAS	9920877
GO:0008236	serine-type peptidase activity	TAS	2203827

Find genes that share ontologies with TPSB2 About GenesLikeMe

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tpsb2):

cellular

hematopoietic system

immune system

skeleton

Find genes that share phenotypes with TPSB2 About GenesLikeMe

Animal Models:
MGI mouse knock-out Tpsb2^tm1.1Mfg for TPSB2

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

TRYB2_HUMAN, P20231: Secreted. Note=Released from the secretory granules upon mast cell activation

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
peroxisome	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

Find genes that share ontologies with TPSB2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TPSB2
Interactions:

GeneGlobe Interaction Network for TPSB2

3 Interacting proteins for TPSB2 (P20231³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCK1	P16333³	I2D: score=1
PIK3R1	P27986³	I2D: score=1
TPSAB1	Q15661³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--

Find genes that share ontologies with TPSB2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for TPSB2 (TRYB2)

2 HMDB Compounds for TPSB2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Kinetensin 1-3	Ile-Ala-Arg;KT(1-3)	--	--
Kinetensin 4-8	KT(4-8);Arg-His-Pro-Tyr-Phe	51833-69-3	--

4 DrugBank Compounds for TPSB2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Amido Phenyl Pyruvic Acid	--	--	target	--	17139284 17016423
(5-(aminomethyl)-2H-spiro[benzofuran-3,4'-piperidine]-1'-yl)(5-(phenylethynyl)furan-2-yl)methanone	--	--	target	--	10592235
[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE	--	--	target	--	10592235
4-PIPERIDIN-4-YLBUTANAL	--	--	target	--	--

1 Novoseek inferred chemical compound relationship for TPSB2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	49.8	2	8039831 (1), 18039527 (1)

Find genes that share compounds with TPSB2 About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TPSB2 gene:

NM_024164.5

Unigene Cluster for TPSB2:

Tryptase beta 2 (gene/pseudogene)

Hs.592982 [show with all ESTs]

Unigene Representative Sequence: BC065923

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000339687(uc010brk.1) ENST00000606293 ENST00000445910 ENST00000430512(uc002ckx.3 uc002cky.3)

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Additional mRNA sequence:

AK308208.1 BC029356.1 BC065923.1 FJ931119.1 FJ931120.1 M33492.1 M37488.1 S55551.1

3 DOTS entries:

DT.446428 DT.100749578 DT.75138719

Selected AceView cDNA sequences (see all 82):

AA887888 AI581938 BQ719498 BF876081 BV200561 BQ082929 BM991728 M33493

BM989945 BQ003361 CA867461 BV200560 BU787858 BM663927 BV207479 BV185679

BI819421 AI832733 BV207482 AI678487 BV207480 AI610847 CD672689 BV201257

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TPSB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TPSB2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 3) fully expand


Gut Tube (Gastrointestinal Tract)
Pharynx

Lung (Respiratory System)

Dermis (Integumentary System)

TPSB2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TPSB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.592982

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TPSB2 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tpsb2^{1 , 5}	tryptase beta 2^{1, 5}	77.35(n)¹ 78.38(a)¹		17 (12.53 cM)⁵ 17229¹ NM_010781.3¹ NP_034911.3¹ 25366550⁵
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	39(a) 33(a)	many ↔ many many ↔ many	GL343253.1(1843088-1847017) GL343287.1(1454751-1470659)

ENSEMBL Gene Tree for TPSB2 (if available)
TreeFam Gene Tree for TPSB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for TPSB2 gene

TPSAB1¹ ² PRSS46² PRSS48² PRSS22² PRSS27² TMPRSS9² PRSS21² PRSS45²

TPSG1² TPSD1² PRSS38² PRSS53² PRSS50² PRSS42² PRSS36² PRSS33²

PRSS8²

Selected SIMAP similar genes for TPSB2 using alignment to 4 protein entries: TRYB2_HUMAN (see all proteins) (see all similar genes):

tryptaseB tryptaseC TPSAB1 TPSD1 MGC52282 F12

TPSG1 PRSS29P PRSS22 DKFZp586F0824 PRSS27 PRSS45

CELA3A CELA2A F2 PRSS36 PRSS42 ELA2A

Find genes that share paralogs with TPSB2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Polymorphic Variants from UniProtKB/Swiss-Prot

TRYB2_HUMAN, P20231: There are two alleles; beta-II and beta-III. Beta-II is the most commun allele. There are two forms

of the beta-III allele, a short and a long form. The short form (also named frameshifted form) is carried by 23%

and 19% of individuals of European and African ancestry but 0% of Asian subjects. In the human genome reference

version GRCh37/hg19, the allele beta-III short form is represented

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200130057^1,2	C	--	1277888(+)	`GAGTT-/CAAGGC`	1	--	ds500¹		0	--	--	--	--
rs139195821^1,2		--	1277991(+)	`TGGACA/GGAGGG`	1	--	ds500¹		0	--	--	--	--
rs185804080^1,2		--	1277999(+)	`GGGGCA/CGGGAG`	1	--	ds500¹		0	--	--	--	--
rs143206354^1,2		--	1278000(+)	`GGGCCA/GGGAGA`	1	--	ds500¹		0	--	--	--	--
rs55980846^1,2	C	--	1278037(+)	`GGCTCA/GTGATG`	1	--	ds500¹		0	--	--	--	--
rs75841489^1,2	C,F	--	1278063(+)	`CCCGGC/TGACCA`	1	--	ds500¹		2		NA	8
rs375069122^1,2	C	--	1278183(+)	`CAGCCC/TGGGGA`	1	--	ds500¹		0	--	--	--	--
rs1060344^1,2	F	--	1278414(-)	`CCTCCG/AGCCCT`	1	--	ut3¹		1		MN	184
rs1060341^1,2	C,F	--	1278424(+)	`GGCCCA/GGTGCA`	1	--	ut3¹		12		EA NA MN WA CSA	601
rs183132305^1,2	C	--	1278457(+)	`AGGGGA/GCTCAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TPSB2 (1277272 - 1280214 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for TPSB2 (see all 24): About this table

Variant ID	Type	Subtype	PubMed ID
esv2750305	CNV	Deletion	23290073
esv2422427	CNV	Duplication	17116639
nsv833117	CNV	Loss	17160897
nsv904954	CNV	Loss	21882294
esv29040	CNV	Loss	19812545
nsv904950	CNV	Loss	21882294
dgv2522n71	CNV	Loss	21882294
nsv471066	CNV	Loss	18288195
dgv2505n71	CNV	Loss	21882294
dgv2514n71	CNV	Loss	21882294

Human Gene Mutation Database (HGMD): TPSB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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OMIM gene information: 191081 OMIM disorders: --

1 disease for TPSB2:
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asthma

1 inferred disease relationship from the University of Copenhagen DISEASES database for TPSB2:

Dermatitis herpetiformis

Find genes that share disorders with TPSB2 About GenesLikeMe

Genetic Association Database (GAD): TPSB2
Human Genome Epidemiology (HuGE) Navigator: TPSB2 (1 document)

Export disorders for TPSB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TPSB2 gene, integrated from 10 sources (see all 31):
(articles sorted by number of sources associating them with TPSB2)

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Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. (PubMed id 19748655)^{1, 2, 3, 4} Trivedi N.N.... Caughey G.H. (J. Allergy Clin. Immunol. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3. (PubMed id 9920877)^{1, 2} Pallaoro M.... Caughey G.H. (J. Biol. Chem. 1999)
The structure of the human betaII-tryptase tetramer: fo(u)r better or worse. (PubMed id 10500112)^{1, 2} Sommerhoff C.P.... Bergner A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore. (PubMed id 9521329)^{1, 2} Pereira P.J.B.... Bode W. (Nature 1998)
Characterization of a tryptase mRNA expressed in the human basophil cell line KU812. (PubMed id 8434231)^{1, 2} Blom T. and Hellman L. (Scand. J. Immunol. 1993)
Cloning and characterization of a second complementary DNA for human tryptase. (PubMed id 2203827)^{1, 2} Miller J.S.... Schwartz L.B. (J. Clin. Invest. 1990)
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. (PubMed id 2187193)^{1, 2} Vanderslice P....Caughey G.H. (Proc. Natl. Acad. Sci. U.S.A. 1990)
Active monomers of human beta-tryptase have expanded substrate specificities. (PubMed id 18039527)^{2, 9} Fukuoka Y. and Schwartz L.B. (Int. Immunopharmacol. 2007)
Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. (PubMed id 10898108)^{1, 9} Guida M.... Hall J. (Pharmacogenetics 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64499	HGNC: 14120	AceView: TPS1.1	Ensembl:ENSG00000197253	euGenes: HUgn64499
ECgene: TPSB2	H-InvDB: TPSB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TPSB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TPSB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TPSB2 gene:
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GeneCards and IP:
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Tryptase Beta 2 (Gene/Pseudogene)

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