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Aliases for TPSB2 Gene

Aliases for TPSB2 Gene

  • Tryptase Beta 2 (Gene/Pseudogene) 2 3
  • TPS2 3 4 6
  • EC 3.4.21.59 4 63
  • Mast Cell Tryptase Beta III 3
  • Mast Cell Tryptase Beta II 3
  • Tryptase Beta III 2
  • Tryptase Beta II 2
  • Tryptase Beta 2 2
  • Tryptase Beta-2 3
  • Tryptase II 4
  • Tryptase-2 4
  • TryptaseB 3
  • TryptaseC 3
  • EC 3.4.21 63

External Ids for TPSB2 Gene

Previous GeneCards Identifiers for TPSB2 Gene

  • GC16U990168
  • GC16P001231
  • GC16P001191
  • GC16P001234
  • GC16M001219
  • GC16M001278
  • GC16M001279
  • GC16M001280
  • GC16M001281

Summaries for TPSB2 Gene

Entrez Gene Summary for TPSB2 Gene

  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for TPSB2 Gene

TPSB2 (Tryptase Beta 2 (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with TPSB2 include asthma. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.

UniProtKB/Swiss-Prot for TPSB2 Gene

  • Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).

Gene Wiki entry for TPSB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPSB2 Gene

Genomics for TPSB2 Gene

Regulatory Elements for TPSB2 Gene

Genomic Location for TPSB2 Gene

Start:
1,227,272 bp from pter
End:
1,230,184 bp from pter
Size:
2,913 bases
Orientation:
Minus strand

Genomic View for TPSB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TPSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPSB2 Gene

Proteins for TPSB2 Gene

  • Protein details for TPSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20231-TRYB2_HUMAN
    Recommended name:
    Tryptase beta-2
    Protein Accession:
    P20231
    Secondary Accessions:
    • D2E6S0
    • D2E6S2
    • O95827
    • Q15664
    • Q9UQI6
    • Q9UQI7

    Protein attributes for TPSB2 Gene

    Size:
    275 amino acids
    Molecular mass:
    30515 Da
    Quaternary structure:
    • Homotetramer. The active tetramer is converted to inactive monomers at neutral and acidic pH in the absence of heparin. Low concentrations of inactive monomers become active monomers at pH 6.0 in the presence of heparin. When the concentration of active monomers is higher, they convert to active monomers and then to active tetramers. These monomers are active and functionally distinct from the tetrameric enzyme. In contrast to the hidden active sites in the tetrameric form, the active site of the monomeric form is accessible for macromolecular proteins and inhibitors eg: fibrinogen which is a substrate for the monomeric but not for the tetrameric form. The monomeric form forms a complex with SERPINB6.

    Three dimensional structures from OCA and Proteopedia for TPSB2 Gene

neXtProt entry for TPSB2 Gene

Proteomics data for TPSB2 Gene at MOPED

Post-translational modifications for TPSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TPSB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TPSB2 Gene

Suggested Antigen Peptide Sequences for TPSB2 Gene

Graphical View of Domain Structure for InterPro Entry

P20231

UniProtKB/Swiss-Prot:

TRYB2_HUMAN :
  • P20231
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Tryptase subfamily.
genes like me logo Genes that share domains with TPSB2: view

No data available for Gene Families for TPSB2 Gene

Function for TPSB2 Gene

Molecular function for TPSB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Arg- -Xaa, Lys- -Xaa, but with more restricted specificity than trypsin
UniProtKB/Swiss-Prot Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).

Enzyme Numbers (IUBMB) for TPSB2 Gene

Gene Ontology (GO) - Molecular Function for TPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 9920877
GO:0005515 protein binding IPI 14670919
GO:0008236 serine-type peptidase activity TAS 2203827
genes like me logo Genes that share ontologies with TPSB2: view
genes like me logo Genes that share phenotypes with TPSB2: view

Animal Models for TPSB2 Gene

MGI Knock Outs for TPSB2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSB2

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TPSB2 Gene

Localization for TPSB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPSB2 Gene

Secreted. Note=Released from the secretory granules upon mast cell activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TPSB2 Gene COMPARTMENTS Subcellular localization image for TPSB2 gene
Compartment Confidence
extracellular 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for TPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with TPSB2: view

Pathways for TPSB2 Gene

SuperPathways for TPSB2 Gene

No Data Available

Interacting Proteins for TPSB2 Gene

Selected Interacting proteins: P20231-TRYB2_HUMAN for TPSB2 Gene via I2D

Gene Ontology (GO) - Biological Process for TPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with TPSB2: view

No data available for Pathways by source for TPSB2 Gene

Compounds for TPSB2 Gene

(2) HMDB Compounds for TPSB2 Gene

Compound Synonyms Cas Number PubMed IDs
Kinetensin 1-3
  • Ile-Ala-Arg
Not Available
Kinetensin 4-8
  • KT(4-8)
51833-69-3

(1) Novoseek inferred chemical compound relationships for TPSB2 Gene

Compound -log(P) Hits PubMed IDs
serine 49.8 2
genes like me logo Genes that share compounds with TPSB2: view

Transcripts for TPSB2 Gene

mRNA/cDNA for TPSB2 Gene

Unigene Clusters for TPSB2 Gene

Tryptase beta 2 (gene/pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TPSB2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPSB2 Gene

No ASD Table

Relevant External Links for TPSB2 Gene

GeneLoc Exon Structure for
TPSB2
ECgene alternative splicing isoforms for
TPSB2

Expression for TPSB2 Gene

mRNA expression in normal human tissues for TPSB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPSB2 Gene

This gene is overexpressed in Esophagus - Muscularis (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TPSB2 Gene

SOURCE GeneReport for Unigene cluster for TPSB2 Gene Hs.592982

genes like me logo Genes that share expressions with TPSB2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TPSB2 Gene

Orthologs for TPSB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPSB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TPSB2 35
  • 96.83 (n)
  • 96.58 (a)
TPSB2 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC786948 35
  • 82.68 (n)
  • 77.56 (a)
TPSB1 36
  • 76 (a)
ManyToMany
TPSB1 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
LOC100049001 35
  • 81.45 (n)
  • 75.64 (a)
mouse
(Mus musculus)
Mammalia Tpsab1 36
  • 65 (a)
ManyToMany
Tpsb2 35
  • 77.35 (n)
  • 78.38 (a)
Tpsb2 16
Tpsb2 36
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tpsb2 35
  • 75.77 (n)
  • 75.77 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18735 37
  • 39 (a)
CG7432 37
  • 36 (a)
Species with no ortholog for TPSB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TPSB2 Gene

ENSEMBL:
Gene Tree for TPSB2 (if available)
TreeFam:
Gene Tree for TPSB2 (if available)

Paralogs for TPSB2 Gene

genes like me logo Genes that share paralogs with TPSB2: view

Variants for TPSB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TPSB2 Gene

P20231-TRYB2_HUMAN
There are two alleles; beta-II and beta-III. Beta-II is the most commun allele. There are two forms of the beta-III allele, a short and a long form. The short form (also named frameshifted form) is carried by 23% and 19% of individuals of European and African ancestry but 0% of Asian subjects. In the human genome reference version GRCh37/hg19, the allele beta-III short form is represented

Sequence variations from dbSNP and Humsavar for TPSB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1060321 -- 1,228,604(-) CCCCT(C/G/T)CTGTC utr-variant-3-prime
rs1060337 -- 1,228,466(-) TTCCC(C/T)ATCCT utr-variant-3-prime
rs1060341 -- 1,228,424(+) GGCCC(A/G)GTGCA utr-variant-3-prime
rs1060344 -- 1,228,414(-) CCTCC(A/G)GCCCT utr-variant-3-prime
rs1064773 -- 1,229,381(-) CTGCC(A/G)GTCAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TPSB2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2504n71 CNV Loss 21882294
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2514n71 CNV Loss 21882294
dgv2518n71 CNV Loss 21882294
dgv2520n71 CNV Loss 21882294
nsv904937 CNV Gain 21882294
dgv2522n71 CNV Loss 21882294
nsv904948 CNV Gain 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv904955 CNV Loss 21882294
nsv7274 OTHER Inversion 18451855
nsv904956 CNV Gain 21882294
nsv904957 CNV Loss 21882294
nsv833117 CNV Loss 17160897
esv1000058 OTHER Inversion 20482838
esv29040 CNV Loss 19812545
esv2750305 CNV Deletion 23290073
nsv1708 CNV Loss 18451855

Relevant External Links for TPSB2 Gene

HapMap Linkage Disequilibrium report
TPSB2
Human Gene Mutation Database (HGMD)
TPSB2

Disorders for TPSB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TPSB2 Gene including...

Search for TPSB2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TPSB2 Gene

Relevant External Links for TPSB2

Genetic Association Database (GAD)
TPSB2
Human Genome Epidemiology (HuGE) Navigator
TPSB2
genes like me logo Genes that share disorders with TPSB2: view

No data available for UniProtKB/Swiss-Prot for TPSB2 Gene

Publications for TPSB2 Gene

  1. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. (PMID: 19748655) Trivedi N.N. … Caughey G.H. (J. Allergy Clin. Immunol. 2009) 2 3 4 48
  2. Active monomers of human beta-tryptase have expanded substrate specificities. (PMID: 18039527) Fukuoka Y. … Schwartz L.B. (Int. Immunopharmacol. 2007) 4 23
  3. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. (PMID: 14670919) Strik M.C. … Kummer J.A. (Blood 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog. (PMID: 10898108) Guida M. … Hall J. (Pharmacogenetics 2000) 3 23

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